title: Local Anaesthetic Effects of Transcutaneous Amitriptyline in Human Volunteers : a Controlled, Double-blinded, Randomised Study Versus Placebo and Transcutaneous Local Anaesthetic (EMLA(R))

summary: The aim of this study is to assess the local anaesthetic effects of amitriptyline applied on the skin of human volunteers, considering the differential effects on mechanic and thermic sensitivity, the local and general tolerance, and the systemic absorption of the drug. The solution used for dilution of amitriptyline is the only one known to allow transcutaneous absorption of the drug [1]. Considering that the peripheral sensitive fibre is a possible site of action of tricyclic antidepressants for relieving neuropathic pain [2,3], this is a first step study before further assessment of the therapeutic effects of transcutaneous amitriptyline.

ReferenceCitation: Kissin I, McDanal J, Xavier AV. Topical lidocaine for relief of superficial pain in postherpetic neuralgia. Neurology. 1989 Aug;39(8):1132-3.

ReferenceCitation: Sawynok J, Esser MJ, Reid AR. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J Psychiatry Neurosci. 2001 Jan;26(1):21-9. Review.

ReferenceCitation: McQuay HJ, Tramèr M, Nye BA, Carroll D, Wiffen PJ, Moore RA. A systematic review of antidepressants in neuropathic pain. Pain. 1996 Dec;68(2-3):217-27.

ReferenceCitation: Dualé C, Daveau J, Cardot JM, Boyer-Grand A, Schoeffler P, Dubray C. Cutaneous amitriptyline in human volunteers: differential effects on the components of sensory information. Anesthesiology. 2008 Apr;108(4):714-21. doi: 10.1097/ALN.0b013e3181672632.

name: Hospital Practitioner, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Service d’Anesthésie-Réanimation, Hôpital Gabriel-Montpied; CHU Clermont-Ferrand, Centre de Pharmacologie Clinique; Inserm, CIC 501.

family: Dualé

full_name: Christian Dualé

given: Christian

name: Anesthesiology Resident, CHU Clermont-Ferrand, Service d’Anesthésie-Réanimation, Hôpital Gabriel-Montpied.

family: Daveau

full_name: Julie Daveau

given: Julie

name: Professor of Biopharmacy, Univ Clermont1, Fac Pharmacie, Biopharmacie.

family: Cardot

full_name: Jean-Michel Cardot

given: Jean-Michel

name: Lecturer, CHU Clermont-Ferrand, Pharmacie Centrale, Hôpital Gabriel-Montpied; Univ Clermont1, Fac Pharmacie.

family: Boyer-Grand

full_name: Anne Boyer-Grand

given: Anne

name: Professor of Anesthesiology and Intensive Care, CHU Clermont-Ferrand, Service d’Anesthésie-Réanimation, Hôpital Gabriel-Montpied; Univ Clermont1, Fac Médecine.

family: Schoeffler

full_name: Pierre Schoeffler

given: Pierre

name: Professor of Clinical Pharmacology, CHU Clermont-Ferrand, Centre de Pharmacologie Clinique; Univ Clermont1, Fac Médecine; Inserm, CIC 501.

family: Dubray

full_name: Claude Dubray

given: Claude

journal_name: Anesthesiology

title: Cutaneous Amitriptyline in Human Volunteers

lead_sponsor: University Hospital, Clermont-Ferrand


design_allocation: Randomized

intervention_type: Other

status: Recruiting

study_start_date_type: Actual

study_type: Interventional

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

lead_sponsor: Tigenix S.A.U.

enrollment_type: Anticipated

primary_purpose: Treatment

location_country:
Italy
United States
Sweden
Germany
France
Czechia
Poland
Israel
Hungary
Belgium
Puerto Rico
Spain
Denmark
Canada
United Kingdom

acronym: ADMIRE-CD-II

location_facility: North Shore University Hospital - Gastroenterology

location_facility: Istituto Clinico Humanitas Rozzano, IRCCS - IBD Center

location_facility: Dartmouth Hitchcock Medical Center - Cancer Center

location_facility: AZ Groeninge - Campus Kennedylaan - Gastro-enterology

location_facility: McGill University Health Centre - Montreal General Hospital

location_facility: CHU de Liege - Domaine Universitaire du Sart Tilman

location_facility: Mount Sinai Hospital - Toronto - Gastroenterology

location_facility: University of Southern California (USC) Norris Comprehensive Cancer Center

location_facility: CHRU de Nancy -Hopital Brabois Adultes - Service d'Hepato- Gastroenterologie

location_facility: CHRU De Lille - Hopital Claude Huriez - Hepato-Gastro-Enterologie

location_facility: Johns Hopkins Medicine - The Johns Hopkins Hospital

location_facility: University of Kansas Sxchool of Medicine

location_facility: GZA ziekenhuizen - Campus Sint-Vincentius - Gastro-enterology

location_facility: Hospital Universitario Puerta de Hierro Majadahonda

location_facility: Hadassah Medical Organization, Hadassah Medical Center, Ein-

location_facility: UT Southwestern Medical Center - Gastroenterology - Gastroenterology

location_facility: Nottingham University Hospitals NHS Trust - Surgery

location_facility: Harvard Medical School-Beth Israel Deaconess Medical Center

location_facility: Linkoping University Hospital - Department of Surgery

location_facility: The University of Chicago Medicine - Colon & Rectal Surgery

location_facility: Azienda Ospedaliera Universitaria Integrata Verona (AOUI) -

location_facility: University Surgical Associates-Rhode Island Hospital

location_facility: Aarhus University Hospital - Department of Hepatology and Gastroenterology, Lever-Mave- og Tarmsygdomme Klinik, krydspunkt C216

location_facility: Hopital Saint Louis - Gastro-hepatoenterologie

location_facility: University of Massachusetts - colon & rectal surgery

location_facility: Penn State Hershey Medical Center - Surgery

location_facility: Klinikum der Universitat Munchen - Campus Grosshadern

location_facility: UC Irvine Medical Center - Chao Family Comprehensive Cancer

location_facility: Policlinico Universitario Campus Biomedico - UOC di Gastroenterologia

location_facility: Baylor College of Medicine (BCM) - Gastroenterology

location_facility: Medical College of Wisconsin Hub for Collaborative Medicine - Gastroenterology and Hepatology

location_facility: MH Egeszsegugyi Kozpont - Gasztroenterologiai Osztaly

location_facility: NHS Greater Glasgow and Clyde - Glasgow Royal Infirmary (GRI)

location_facility: Policlinico S. Orsola Malpighi, AOU di Bologna-U.O. di Medicina Interna.

location_facility: Morristown Medical Center - Gastroenterology

location_facility: University Colleague London Hospital (UCLH)

location_facility: AOU Policlinico di Modena - Gastroenterologia

location_facility: Centre Hospitalier de l'Universite de Montreal

location_facility: USF Health South Tampa Center for Advanced Healthcare

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Virginia Mason Medical Center - Gastroenterology

location_facility: University of Puerto Rico School of Medicine

location_facility: Weill Medical College of Cornell University

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie

location_facility: Centre Hospitalier Universitaire De Toulouse - Hopital De Ra

location_facility: Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: Azienda Ospedaliero Universitaria S.Maria della Misericordia - Gastroenterologia

location_facility: Kensington Screening Clinic - Gastroenterology

location_facility: Mayo Clinic College of Medicine - Division of Colon and Rectal Surgery - Division of Colon and Rectal Surgery

location_facility: Shaare Zedek Medical Center - Gastroenterology

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - I. sz. Belgyogyaszati Klinika

location_facility: Klinikum der Johann Wolfgang Goethe-Universitat

location_facility: Barnes-Jewish Hospital - Gastroenterology

ipd_sharing: Yes

study_completion_date_type: Anticipated

type: EudraCT Number

source: euctr

title: A Phase-III, Randomized, Double-blind, Parallel-group, Placebo-controlled, International, Multicentre Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Patients With Crohn's Disease Over a Period of 24 Weeks and a Follow-up Period up to 52 Weeks

summary: The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in at least 2 dimensions) confirmed by blinded central magnetic resonance imaging (MRI) assessment at Week 24.

lead_sponsor_type: industriel

status_simplified: Ongoing


title: A Phase I, Single-Blind Study to Determine the Safety, Tolerability and Pharmacodynamic Profiles of a Hepatitis B Antigen Combined With IMP321 Versus the Hepatitis B Antigen Alone and a Reference Vaccine in Healthy Young Male Volunteers

summary: This is a single centre, three single administrations (Days 1, 29 and 57) at increasing doses of IMP321 (3, 10, 30 and 100 µg) in four cohorts of 12 subjects, single blind, randomized study.

status: Completed

study_completion_date_type: Actual

primary_purpose: Basic Science

enrollment_type: Actual

lead_sponsor: Immutep S.A.S.

intervention_type: Biological

status_simplified: Completed


title: IMP321 Phase I Study of Four Increasing Doses (3, 10, 30 and 100 µg) of a New Immunostimulatory Factor (IMP321) Given Alone or as an Adjuvant to a Reference Flu Antigen in Healthy Young Male Volunteers

summary: This study is a single centre, single blind, placebo (step 1) or reference (step 2) randomised study. Healthy young male volunteers will receive single ascending dose of IMP321 in each step (4 doses tested: 3, 10, 30 and 100 µg). In step 1, IMP321 will be given alone and tested versus placebo (physiological saline). In step 2, the association IMP321 + Agrippal (commercially available flu vaccine) will be tested versus Agrippal alone.


ReferenceType: derived

ReferenceCitation: Colombo N, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Meunier J, Cameron T, Maloney L, Goble S, Bedel J, Ledermann JA, Coleman RL. The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma. Gynecol Oncol. 2020 Oct;159(1):101-111. doi: 10.1016/j.ygyno.2020.05.045. Epub 2020 Aug 26.

family: Colombo

full_name: Nicoletta Colombo

given: Nicoletta

sequence: first

family: Oza

full_name: Amit M. Oza

given: Amit M.

sequence: additional

family: Lorusso

full_name: Domenica Lorusso

given: Domenica

family: Aghajanian

full_name: Carol Aghajanian

given: Carol

family: Oaknin

full_name: Ana Oaknin

given: Ana

family: Dean

full_name: Andrew Dean

given: Andrew

family: Weberpals

full_name: Johanne I. Weberpals

given: Johanne I.

family: Clamp

full_name: Andrew R. Clamp

given: Andrew R.

family: Scambia

full_name: Giovanni Scambia

given: Giovanni

family: Leary

full_name: Alexandra Leary

given: Alexandra

family: Holloway

full_name: Robert W. Holloway

given: Robert W.

family: Gancedo

full_name: Margarita Amenedo Gancedo

given: Margarita Amenedo

family: Fong

full_name: Peter C. Fong

given: Peter C.

family: Goh

full_name: Jeffrey C. Goh

given: Jeffrey C.

family: O'Malley

full_name: David M. O'Malley

given: David M.

family: Armstrong

full_name: Deborah K. Armstrong

given: Deborah K.

family: Banerjee

full_name: Susana Banerjee

given: Susana

family: García-Donas

full_name: Jesus García-Donas

given: Jesus

family: Swisher

full_name: Elizabeth M. Swisher

given: Elizabeth M.

family: Meunier

full_name: Juliette Meunier

given: Juliette

family: Cameron

full_name: Terri Cameron

given: Terri

family: Maloney

full_name: Lara Maloney

given: Lara

family: Goble

full_name: Sandra Goble

given: Sandra

family: Bedel

full_name: Josh Bedel

given: Josh

family: Ledermann

full_name: Jonathan A. Ledermann

given: Jonathan A.

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: University College London - UCL Discovery

ReferenceCitation: Ledermann JA, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Cameron T, Maloney L, Goble S, Coleman RL. Rucaparib for patients with platinum-sensitive, recurrent ovarian carcinoma (ARIEL3): post-progression outcomes and updated safety results from a randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2020 May;21(5):710-722. doi: 10.1016/S1470-2045(20)30061-9.

ReferenceCitation: Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators. Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2017 Oct 28;390(10106):1949-1961. doi: 10.1016/S0140-6736(17)32440-6. Epub 2017 Sep 12. Erratum in: Lancet. 2017 Oct 28;390(10106):1948.

evidence: open (via crossref license, author manuscript)

repository_institution: The University of Glasgow - Enlighten: Publications

location_country:
Italy
United States
Germany
France
Israel
Belgium
Australia
New Zealand
Spain
Canada
United Kingdom

location_facility: Azienda Ospedaliero Universitaria Policlinico di Modena

location_facility: CHUM Centre Hospitalier de l'Université de Montréal

location_facility: Hospital Regional Universitario Carlos Haya de Malaga

location_facility: Washington University School of Medicine - Division of Gynaecological Oncology

location_facility: University of Texas MD Anderson Cancer Center

location_facility: The Ohio State University Wexner Medical Center

location_facility: University of California San Francisco (UCSF)

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Karmanos Cancer Institute - Wayne State University

location_facility: Centro Integral Oncológico Clara Campal, Hospital de Madrid Norte-San Chinarro

location_facility: Oncology Institute, Sheba Medical Center

location_facility: Sir Bobby Robson Cancer trials research Centre, Northern Centre For Cancer Care

location_facility: Dr. Horst Schmidt Klinik, Klinik fuer Gynaekologie und Gyn. Onkologie

location_facility: Oncology Unit City Hospital degli Infermi

location_facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale

location_facility: Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi

location_facility: Instituto Valencia de Oncologia-Fundacion

location_facility: Centre Hospitalier Universitaire de Québec

location_facility: Fondazione IRCCS National Cancer Institute

location_facility: University of California Los Angeles (UCLA)

title: Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous and Endometrioid Ovarian Cancer (ARIEL3)

summary: Patients enrolled into this study will be stratified into 3 groups based on gene mutations identified in their tumor tissue. The purpose of this study is to evaluate patient response to maintenance treatment with rucaparib versus placebo. Response to treatment will be analyzed based on homologous recombination (HR) status of tumor samples.


title: Influence of a Simple Information Booklet on the Evolution of Acute Low Back Pain (LBP): a Quasi-experimental Study in a Primary Care Setting.

summary: To assess the impact of standardized written information on outcome in acute LBP.

study_type: Observational

ReferenceCitation: Coudeyre E, Tubach F, Rannou F, Baron G, Coriat F, Brin S, Revel M, Poiraudeau S. Effect of a simple information booklet on pain persistence after an acute episode of low back pain: a non-randomized trial in a primary care setting. PLoS One. 2007 Aug 8;2(8):e706.

lead_sponsor: Sanofi


title: A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects With Light Chain (AL) Amyloidosis

acronym: AFFIRM-AL

summary: A Phase 3 study to evaluate the efficacy and safety of birtamimab plus standard of care compared to placebo plus standard of care in patients with AL amyloidosis in Mayo Stage IV.

ipd_sharing: No

lead_sponsor: Prothena Biosciences Ltd.

location_country:
Italy
United States
Netherlands
Spain
Germany
France
Czechia
Greece
Israel
Poland
Hungary
Australia
Portugal
Turkey
Denmark
Canada
United Kingdom
Korea, Republic of
Taiwan

location_facility: Rabin Medical Center - Beilinson Hospital

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

location_facility: Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele

location_facility: Theagenio Anti-Cancer Hospital of Thessaloniki

location_facility: Manchester University NHS Foundation Trust

location_facility: Centro Hospitalar e Universitário de Coimbra

location_facility: Wake Forest Baptist Health - Comprehensive Cancer Center

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust

location_facility: Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet

location_facility: Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi

location_facility: Centre Hospitalier Universitaire Poitiers

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Di Ancona

location_facility: Hospital Universitari i Politècnic la Fe

location_facility: University Hospital Marqués de Valdecilla

location_facility: University of Michigan Rogel Cancer Center

location_facility: Complejo Asistencial Universitario de Salamanca - Hospital Clínico

location_facility: Semmelweis Egyetem - I. sz. Belgyógyászati Klinika

location_facility: Institut Català d'Oncologia - Hospital Germans Trias i Pujol

location_facility: Froedtert and Medical College of Wisconsin

location_facility: Uniwersyteckie Centrum Kliniczne w Gdańsku

location_facility: Roswell Park Comprehensive Cancer Center

location_facility: The Catholic University of Korea - Seoul St. Mary's Hospital

location_facility: Clinica Universidad de Navarra - Pamplona

location_facility: Institut Català d'Oncologia - Hospital Duran i Reynals

location_facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu

location_facility: Nottingham University Hospitals NHS Trust

location_facility: The Ohio State University College of Medicine


title: A Phase 2 Dose Ranging, Randomized, Double Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis (PBC) With or Without an Inadequate Response to Ursodeoxycholic Acid (UDCA)

summary: A randomized, double-blind study to assess the safety, tolerability, PK and efficacy of EDP-305 in subjects with primary biliary cholangitis

lead_sponsor: Enanta Pharmaceuticals

location_country:
Austria
United States
Netherlands
Germany
France
Australia
Belgium
Spain
Canada
United Kingdom

location_facility: Cambridge University Hospitals NHS Foundation Trust

location_facility: Hospital Universitario Virgen de la Arrixaca

location_facility: American Research Corporation at the Texas Liver Institute

location_facility: University of Pittsburgh Medical Center - Center for Liver Disease

location_facility: The Liver Institute at Methodist Dallas Medical Center

location_facility: University of Iowa Hospitals and Clinics

location_facility: Centre Hospitalier Régional Universitaire de Lille

location_facility: London Health Sciences Centre University Hospital

location_facility: South Denver Gastroenterology - Swedish Medical Center Office

location_facility: Centre Hospitalier Universitaire Amines-Picardie Hôpital Sud

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Digestive Health Specialists of the Southeast

location_facility: Universidad de Valladolid - Hospital Universitario Rio Hortega

location_facility: University of Miami Leonard M. Miller School of Medicine

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: King's College Hospital NHS Foundation Trust

location_facility: Norfolk and Norwich University Hospitals NHS Foundation Trust

location_facility: University Hospitals Birmingham NHS Foundation Trust

location_facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

location_facility: Gastroenterology Consultants of Clearwater

intervention_type: Drug


title: Aortic Stenosis in Elderly : Determinant of Progression. COFRASA (French Cohort)

summary: Aortic stenosis (AS) is AS is caused by calcium deposits in the aortic valve. Calcification is progressive and eventually leads to reduced leaflet motion with obstruction of the left ventricular outflow. The only treatment is surgery. There are evidences that AS is a regulated process with similarities to atherosclerosis but determinants of AS progression are unknown. The study aims at evaluating these determinants and more specifically the role of lipids, inflammation and platelet aggregation.

status: Unknown status

time_perspective: Prospective

ReferenceCitation: Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ. Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification. JAMA Cardiol. 2019 Jul 1;4(7):620-627. doi: 10.1001/jamacardio.2019.1581. Erratum in: JAMA Cardiol. 2019 Jul 1;4(7):714.

name: Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada

name: Department of Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, Canada

family: Perrot

full_name: Nicolas Perrot

given: Nicolas

name: Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec City, Québec, Canada

family: Thériault

full_name: Sébastien Thériault

given: Sébastien

name: L'Institut du Thorax, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université de Nantes, Nantes, France

family: Dina

full_name: Christian Dina

given: Christian

name: McGill University Health Center Research Institute, Montreal, Québec, Canada

family: Chen

full_name: Hao Yu Chen

given: Hao Yu

name: Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands

family: Boekholdt

full_name: S. Matthijs Boekholdt

given: S. Matthijs

family: Rigade

full_name: Sidwell Rigade

given: Sidwell

family: Després

full_name: Audrey-Anne Després

given: Audrey-Anne

family: Poulin

full_name: Anthony Poulin

given: Anthony

family: Capoulade

full_name: Romain Capoulade

given: Romain

family: Le Tourneau

full_name: Thierry Le Tourneau

given: Thierry

name: Department of Cardiology, Assistance Publique–Hôpitaux de Paris, Bichat Hospital, Paris, France

name: University of Ottawa Heart Institute, Ottawa, Ontario, Canada

family: Messika-Zeitoun

full_name: David Messika-Zeitoun

given: David

family: Trottier

full_name: Mikaël Trottier

given: Mikaël

family: Tessier

full_name: Michel Tessier

given: Michel

family: Guimond

full_name: Jean Guimond

given: Jean

family: Nadeau

full_name: Maxime Nadeau

given: Maxime

family: Engert

full_name: James C. Engert

given: James C.

name: Medical Research Council Epidemiology Unit, Cambridge, United Kingdom

family: Khaw

full_name: Kay-Tee Khaw

given: Kay-Tee

name: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

family: Wareham

full_name: Nicholas J. Wareham

given: Nicholas J.

family: Dweck

full_name: Marc R. Dweck

given: Marc R.

name: Department of Surgery, Faculty of Medicine, Université Laval, Québec City, Québec, Canada

family: Mathieu

full_name: Patrick Mathieu

given: Patrick

family: Pibarot

full_name: Philippe Pibarot

given: Philippe

family: Schott

full_name: Jean-Jacques Schott

given: Jean-Jacques

family: Thanassoulis

full_name: George Thanassoulis

given: George

family: Clavel

full_name: Marie-Annick Clavel

name: Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, Canada

repository_institution: Université Laval - Corpus Université Laval

ReferenceCitation: Pawade T, Clavel MA, Tribouilloy C, Dreyfus J, Mathieu T, Tastet L, Renard C, Gun M, Jenkins WSA, Macron L, Sechrist JW, Lacomis JM, Nguyen V, Galian Gay L, Cuéllar Calabria H, Ntalas I, Cartlidge TRG, Prendergast B, Rajani R, Evangelista A, Cavalcante JL, Newby DE, Pibarot P, Messika Zeitoun D, Dweck MR. Computed Tomography Aortic Valve Calcium Scoring in Patients With Aortic Stenosis. Circ Cardiovasc Imaging. 2018 Mar;11(3):e007146. doi: 10.1161/CIRCIMAGING.117.007146.

name: From the Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (T.P., W.S.A.J., T.R.G.C., D.E.N., M.R.D.); Institut Universitaire de Cardiology et de Pneumologie de Québec (Quebec Heart and Lung Institute), Laval University, Canada (M.-A.C., L.T., P.P.); Department of Cardiology, Centre Hospitalier Universitaire d’Amiens, Picardie, France (C.T., M.G.); Centre Cardiologique du Nord, Saint-Denis, France (J.D., L.M.); Department of Cardiology, Bichat Hospital, Paris, France (T.M.,...

publisher: Ovid Technologies (Wolters Kluwer Health)

ReferenceCitation: Arangalage D, Nguyen V, Robert T, Melissopoulou M, Mathieu T, Estellat C, Codogno I, Huart V, Duval X, Cimadevilla C, Vahanian A, Dehoux M, Messika-Zeitoun D. Determinants and prognostic value of Galectin-3 in patients with aortic valve stenosis. Heart. 2016 Jun 1;102(11):862-8. doi: 10.1136/heartjnl-2015-308873. Epub 2016 Feb 19.

ReferenceCitation: Chin CW, Messika-Zeitoun D, Shah AS, Lefevre G, Bailleul S, Yeung EN, Koo M, Mirsadraee S, Mathieu T, Semple SI, Mills NL, Vahanian A, Newby DE, Dweck MR. A clinical risk score of myocardial fibrosis predicts adverse outcomes in aortic stenosis. Eur Heart J. 2016 Feb 21;37(8):713-23. doi: 10.1093/eurheartj/ehv525. Epub 2015 Oct 21.

repository_institution: University of Edinburgh - Edinburgh Research Explorer

ReferenceCitation: Nguyen V, Cimadevilla C, Estellat C, Codogno I, Huart V, Benessiano J, Duval X, Pibarot P, Clavel MA, Enriquez-Sarano M, Vahanian A, Messika-Zeitoun D. Haemodynamic and anatomic progression of aortic stenosis. Heart. 2015 Jun;101(12):943-7. doi: 10.1136/heartjnl-2014-307154. Epub 2015 Feb 5.

ReferenceCitation: Cimadevilla C, Cueff C, Hekimian G, Dehoux M, Lepage L, Iung B, Duval X, Huart V, Tubach F, Vahanian A, Messika-Zeitoun D. Prognostic value of B-type natriuretic peptide in elderly patients with aortic valve stenosis: the COFRASA-GENERAC study. Heart. 2013 Apr;99(7):461-7. doi: 10.1136/heartjnl-2012-303284. Epub 2013 Jan 24.

title: Prognostic value of B-type natriuretic peptide in elderly patients with aortic valve stenosis: the COFRASA–GENERAC study

ReferenceCitation: Hekimian G, Boutten A, Flamant M, Duval X, Dehoux M, Benessiano J, Huart V, Dupré T, Berjeb N, Tubach F, Iung B, Vahanian A, Messika-Zeitoun D. Progression of aortic valve stenosis is associated with bone remodelling and secondary hyperparathyroidism in elderly patients--the COFRASA study. Eur Heart J. 2013 Jul;34(25):1915-22. doi: 10.1093/eurheartj/ehs450. Epub 2013 Jan 17.

title: Progression of aortic valve stenosis is associated with bone remodelling and secondary hyperparathyroidism in elderly patients—the COFRASA study


title: Corticosteroids and Cataracts : Prospective Study of the Impact of Systemic Corticosteroid Therapy on Lens Transparency Evaluated by Scheimpflug Photography and Quantification of Lens Autofluorescence.

summary: Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.

design_allocation: Non-Randomized

primary_purpose: Prevention

lead_sponsor_type: academique


title: A Multicenter Open-Label Phase II Study of Velcade Combined With High-Dose Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma

summary: The objective of this study is to evaluate the efficacy and safety of Velcade plus dexamethasone used as induction chemotherapy prior to autologous transplantation.

status: Terminated

lead_sponsor: Nantes University Hospital

status_simplified: Unknown


title: Study of Incidence, of Mechanisms and Prognosis of the Thrombopenia From Patients of Reanimation.

summary: About 40 % of the patients in reanimation are thrombopenics and the causes are not well known (reduction in platelet's production, increase in their destruction...). This protocol studies the epidemiology of thrombopenia for these patients and the impacts of cost and mortality in order to bring patients best medical cares.


title: AmBisome® in Combination With Caspofungin Versus AmBisome® High Dose Regimen for the Treatment of Invasive Aspergillosis in Immunocompromized Patients: Randomized Pilot Study.

summary: Combination therapy of caspofungin and amphotericin B could be a useful treatment option in invasive fungal disease, but before it can be routinely recommended; carefully controlled and well-designed randomized clinical trials are needed.

lead_sponsor: Gilead Sciences


title: Positive Effect of Ischemic Postconditioning During Acute Myocardial Infarction

summary: The purpose of this study is to determine whether brief periods of ischemia performed just at the time of reperfusion -postconditioning- can reduce coronary endothelial dysfunction and infarct size in humans

lead_sponsor: French Cardiology Society

intervention_type: Procedure


title: Effect of Enteral Immunonutrition During Chemoradiotherapy in Patients With Head and Neck Cancer or Esophageal Cancer

summary: The aim of this study is to investigate if enteral immunonutrition of head and neck or esophageal cancer patients, using an arginine, omega 3 fatty acid, nucleotides-enhanced diet [Impact (R), Novartis] versus a standard enteral nutrition (control, Novartis), could improve clinical outcomes (mucositis frequency, treatment tolerance), nutritional and immune status, and life quality parameters.

ReferenceType: background

ReferenceCitation: van Bokhorst-de van der Schuer, van Leeuwen PA, Kuik DJ, Klop WM, Sauerwein HP, Snow GB, Quak JJ. The impact of nutritional status on the prognoses of patients with advanced head and neck cancer. Cancer. 1999 Aug 1;86(3):519-27.

ReferenceCitation: Nozoe T, Kimura Y, Ishida M, Saeki H, Korenaga D, Sugimachi K. Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for oesophageal carcinoma. Eur J Surg Oncol. 2002 Jun;28(4):396-400.

ReferenceCitation: Gianotti L, Braga M, Nespoli L, Radaelli G, Beneduce A, Di Carlo V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 2002 Jun;122(7):1763-70.

ReferenceCitation: de Luis DA, Arranz M, Aller R, Izaola O, Cuellar L, Terroba MC. Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients. Eur J Clin Nutr. 2005 Jan;59(1):145-7.

ReferenceCitation: Talvas J, Garrait G, Goncalves-Mendes N, Rouanet J, Vergnaud-Gauduchon J, Kwiatkowski F, Bachmann P, Bouteloup C, Bienvenu J, Vasson MP. Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. Clin Nutr. 2015 Oct;34(5):810-7. doi: 10.1016/j.clnu.2014.12.002. Epub 2014 Dec 9.

family: Talvas

full_name: J. Talvas

given: J.

family: Garrait

full_name: G. Garrait

given: G.

family: Goncalves-Mendes

full_name: N. Goncalves-Mendes

given: N.

family: Rouanet

full_name: J. Rouanet

family: Vergnaud-Gauduchon

full_name: J. Vergnaud-Gauduchon

family: Kwiatkowski

full_name: F. Kwiatkowski

given: F.

family: Bachmann

full_name: P. Bachmann

given: P.

family: Bouteloup

full_name: C. Bouteloup

given: C.

family: Bienvenu

full_name: J. Bienvenu

family: Vasson

full_name: M.-P. Vasson

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Clinical Nutrition

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

ReferenceCitation: Vasson MP, Talvas J, Perche O, Dillies AF, Bachmann P, Pezet D, Achim AC, Pommier P, Racadot S, Weber A, Ramdani M, Kwiatkowski F, Bouteloup C. Immunonutrition improves functional capacities in head and neck and esophageal cancer patients undergoing radiochemotherapy: a randomized clinical trial. Clin Nutr. 2014 Apr;33(2):204-10. doi: 10.1016/j.clnu.2013.06.008. Epub 2013 Jun 20.

family: Perche

full_name: O. Perche

given: O.

family: Dillies

full_name: A.-F. Dillies

family: Pezet

full_name: D. Pezet

given: D.

family: Achim

full_name: A.-C. Achim

family: Pommier

full_name: P. Pommier

family: Racadot

full_name: S. Racadot

given: S.

family: Weber

full_name: A. Weber

given: A.

family: Ramdani

full_name: M. Ramdani

given: M.

title: Immunonutrition improves functional capacities in head and neck and esophageal cancer patients undergoing radiochemotherapy: A randomized clinical trial


title: A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF Therapy

summary:
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. This study will evaluate how well risankizumab works compared to ustekinumab. This study will assess change in Crohn's Disease Activity Index (CDAI).

Risankizumab is an investigational drug being developed for the treatment of Crohn's Disease (CD). Ustekinumab is an approved drug for the treatment of moderate and severe CD. Participants are randomly assigned to one of the three treatment groups. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to ustekinumab. Around 508 adult participants with moderate to severe CD will be enrolled in approximately 307 sites worldwide.

In Part 1, participants assigned to risankizumab will receive intravenous (IV) doses of risankizumab at Week 0, 4,8 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. Participants assigned to ustekinumab will receive intravenous (IV) dose of ustekinumab at Week 0 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. In Part 2, participants who received risankizumab in Part 1 and completed the Week 48 visit will continue to receive SC risankizumab for up to an additional 220 weeks.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

lead_sponsor: AbbVie

location_country:
Greece
Romania
Australia
Belgium
Russian Federation
Ukraine
France
Poland
Slovakia
Argentina
Canada
Korea, Republic of
South Africa
Chile
Sweden
Switzerland
Netherlands
Bulgaria
Hungary
China
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Czechia
Israel
Spain
Turkey

location_facility: CHRU Nancy - Hôpitaux de Brabois /ID# 223767

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 223336

location_facility: Hopital Universitaire Purpan Hopital Rangueil /ID# 224732

location_facility: Peking University Third Hospital /ID# 224479

location_facility: Second Multiprofile Hospital f /ID# 223425

location_facility: Elisabeth Tweesteden Ziekenhuis /ID# 223229

location_facility: A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 223330

location_facility: Lviv Regional Clinical Hospital /ID# 223661

location_facility: QEII - Health Sciences Centre /ID# 223748

location_facility: Univ Emergency Hosp Bucharest /ID# 223579

location_facility: Nottingham University Hospitals NHS Trust /ID# 224179

location_facility: CHU Bordeaux - Hopital Haut Lévêque /ID# 223764

location_facility: Intercity Advanced Gastroentertology Center /ID# 224313

location_facility: Universitair Ziekenhuis Leuven /ID# 223901

location_facility: Digestive Disease Associates, LTD /ID# 223462

location_facility: Universitair Medisch Centrum Utrecht /ID# 223696

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 223405

location_facility: Yale Univ Digestive Diseases /ID# 224463

location_facility: Kaiser Clinica e Hospital Dia /ID# 223232

location_facility: Medizinische Hochschule Hannover /ID# 223402

location_facility: Gazi Universitesi Tip Fakultes /ID# 223386

location_facility: ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 223322

location_facility: University of Vermont Medical Center /ID# 224047

location_facility: University of California, San Francisco /ID# 223621

location_facility: Targu Mures Emergency Clinical County Hospital /ID# 223613

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 223482

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 223319

location_facility: West China Hospital, Sichuan University /ID# 224786

location_facility: NHS Greater Glasgow and Clyde /ID# 223653

location_facility: University General Hospital of Ioannina /ID# 223339

location_facility: Advanced Gastroenterology, P.C /ID# 224396

location_facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 223403

location_facility: Hospital Universitario de Bellvitge /ID# 225719

location_facility: The Third Xiangya Hospital of Central South University /ID# 224754

location_facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 224428

location_facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 224048

location_facility: Medizinische Universitaet Wien /ID# 223438

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 223773

location_facility: Hospital General Universitario Alicante /ID# 223552

location_facility: Royal Devon and Exeter NHS Trust Hospital /ID# 223644

location_facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 223508

location_facility: East and North Hertfordshire NHS Trust /ID# 224607

location_facility: General Hospital of Thessaloniki Hippokrateio /ID# 223887

location_facility: City Clinical Hospital No. 31 /ID# 224223

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 223342

location_facility: Nature Coast Clinical Research - Inverness /ID# 223600

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224580

location_facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 223440

location_facility: Universitaetsklinikum St. Poelten /ID# 223437

location_facility: Hospital Clinic de Barcelona /ID# 223355

location_facility: Penn State Milton S. Hershey Medical Center /ID# 224216

location_facility: Centro Medico Zambrano Hellion /ID# 224025

location_facility: Beth Israel Deaconess Medical Center /ID# 228094

location_facility: The Chaim Sheba Medical Center /ID# 223557

location_facility: Inselspital, Universitätsspital Bern /ID# 223590

location_facility: Praxiszentrum fuer Gastroenterologie /ID# 223409

location_facility: Western Connecticut Medical Group /ID# 223478

location_facility: Policlinico Agostino Gemelli /ID# 223323

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 223668

location_facility: Centro de Investigacion en Artritis y Osteoporosis S.C. /ID# 227179

location_facility: Cabinet Particular Policlinic Algomed /ID# 223578

location_facility: The First Affiliated Hospital of Nanchang University /ID# 224507

location_facility: Hunter Holmes McGuire VA Medical Center /ID# 223586

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 224545

location_facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 223327

location_facility: Cambridge University Hospitals NHS Foundation Trust /ID# 223648

location_facility: Percuro Clinical Research, Ltd /ID# 223747

location_facility: Universitatsklinikum Mannheim /ID# 223410

location_facility: Radboud Universitair Medisch Centrum /ID# 233750

location_facility: University Hospital Southampton NHS Foundation Trust /ID# 224351

location_facility: Zhongshan Hospital Xiamen University /ID# 224663

location_facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 223512

location_facility: CHU UCL Namur - site Godinne /ID# 223905

location_facility: Oxford University Hospitals NHS Foundation Trust /ID# 223645

location_facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 223333

location_facility: General Hospital of Athens Ippokratio /ID# 223344

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 223655

location_facility: Hospital Italiano de Buenos Aires /ID# 224550

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 223597

location_facility: Columbia Univ Medical Center /ID# 224215

location_facility: Hospital Universitario Germans Trias i Pujol /ID# 223436

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 223338

location_facility: The Edith Wolfson Medical Center /ID# 227652

location_facility: Medical Center of LLC DIASERVIS /ID# 224249

location_facility: St George's University Hospitals NHS Foundation Trust /ID# 223656

location_facility: Renmin Hospital of Wuhan University /ID# 224525

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 223324

location_facility: Wake Forest Baptist Medical Center /ID# 224406

location_facility: Northern Care Alliance NHS Group /ID# 223650

location_facility: Texas Digestive Disease Consultants - Southlake /ID# 224264

location_facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 223233

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 223774

location_facility: Advanced Research Institute, Inc /ID# 223470

location_facility: Omega Research Maitland, LLC /ID# 223463

location_facility: Hospital General Universitario Gregorio Maranon /ID# 223317

location_facility: Soroka University Medical Center /ID# 223556

location_facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 223456

location_facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 223387

location_facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 223411

location_facility: Universitaetsklinikum Frankfurt /ID# 223396

location_facility: The Second Affiliated Hospital of Zhengzhou University /ID# 224528

location_facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 223340

location_facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 223768

location_facility: Vanderbilt University Medical Center /ID# 224610

location_facility: Universitaetsklinikum Erlangen /ID# 223404

location_facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 223499

location_facility: Belfast Health and Social Care Trust /ID# 224023

location_facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 223335

location_facility: Zhujiang Hospital of Southern Medical University /ID# 224524

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 223525

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 226554

location_facility: Faculdade de Medicina do ABC /ID# 223231

location_facility: Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 223902

location_facility: Immanuel Kant Baltic Federal University /ID# 224224

location_facility: Chu de Nice-Hopital L'Archet Ii /Id# 223763

location_facility: North Shore University Hospital /ID# 224356

location_facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine /ID# 224421

location_facility: Malopolskie Centrum Kliniczne /ID# 223708

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 223700

location_facility: Cleveland Clinic Main Campus /ID# 223691

location_facility: Sociedad de Servicios Medicos Walsen Galmez /ID# 224032

location_facility: Gastroenterology Group Naples /ID# 223516

location_facility: Consultants in Gastroenterology - Columbia NE /ID# 224263

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 223755

location_facility: CHU Reims - Hôpital Robert Debre /ID# 224530

location_facility: Groupe Sante CHC - Clinique du MontLegia /ID# 223898

location_facility: Guy's and St Thomas' NHS Foundation Trust /ID# 223647

location_facility: Southern California Res. Ctr. /ID# 223484

location_facility: Medical Research Center of CT /ID# 223540

location_facility: Changzhou No.2 People's Hospital /ID# 238965

location_facility: CSSS Alphonse-Desjardins, CHAU de Levis /ID# 223744

location_facility: West Virginia University Hospitals /ID# 223501

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 223277

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 223256

location_facility: CHU Grenoble - Hopital Michallon /ID# 224091

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 223395

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 223497

location_facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 223510

location_facility: CINME Centro de Investigaciones Metabolicas /ID# 223447

location_facility: Royal Victoria Hospital / McGill University Health Centre /ID# 223743

location_facility: Tel Aviv Sourasky Medical Center /ID# 223551

location_facility: Southern Star Research Institute, LLC /ID# 223598

location_facility: Azienda Ospedaliero Universitaria di Cagliari- Presidio Ospedaliero /ID# 223474

location_facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 224222

location_facility: Hospital Universitario y Politecnico La Fe /ID# 223314

location_facility: Scott Shulman Medicine Professional Corporation /ID# 223754

location_facility: NorthShore University HealthSystem /ID# 223538

location_facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 223356

location_facility: Digestive Disease Specialists /ID# 223528

location_facility: Acibadem City Clinic Tokuda University Hospital EAD /ID# 223757

location_facility: Lenasia Clinical Trial Centre /ID# 224306

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 223822

location_facility: Nemocnice Ceske Budejovice a.s. /ID# 224219

location_facility: Fondazione PTV Policlinico Tor Vergata /ID# 223332

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 224662

location_facility: Hospital Clinico Universitario San Carlos /ID# 223367

location_facility: Massachusetts General Hospital /Id# 224335

location_facility: CHU Montpellier - Hôpital Saint Eloi /ID# 223860

location_facility: Ospedale Policlinico San Martino /ID# 223329

location_facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 223654

location_facility: Karolinska University Hospital Solna /ID# 223423

location_facility: Hospital Universitario de Fuenlabrada /ID# 223371

location_facility: Universitatsklinik Regensburg /ID# 223407

location_facility: Assaf Harofeh Medical Center /ID# 224686

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 223302

location_facility: Medical University of South Carolina /ID# 223485

location_facility: The Second Hospital Central South University /ID# 224684

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 223325

location_facility: Virginia Mason Medical Center /ID# 224253

location_facility: Hospital Britanico de Buenos Aires /ID# 223432

location_facility: Universitaetsklinikum Freiburg /ID# 223406

location_facility: Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 224017

location_facility: Shengjing Hospital of China Medical University /ID# 224478

location_facility: Louisana Research Center, LLC /ID# 223503

location_facility: Baylor College of Medicine - Baylor Medical Center /ID# 223488

location_facility: Medical Care & Research SA de CV /ID# 223974

location_facility: Plains Clinical Research Center, LLC /ID# 223522

location_facility: Hospital Universitario Central de Asturias /ID# 223368

location_facility: Hospital Privado Univesitario /ID# 223433

location_facility: Tyler Research Institute, LLC /ID# 223469

location_facility: Hospital Universitario Virgen del Rocio /ID# 223476

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 223765

location_facility: Hospital Clinico Universitario de Valencia /ID# 223321

location_facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 223465

location_facility: Nemocnice Horovice - NH Hospital a.s /ID# 223276

location_facility: Hoag Memorial Hosp Presbyterian /ID# 224373

location_facility: London Health Sciences Center /ID# 223741

location_facility: Hospital Universitario La Paz /ID# 223318

location_facility: Medizinisches Versorgungszentrum Portal 10 /ID# 224552

location_facility: King's College Hospital NHS Foundation Trusts /ID# 223649

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 224420

location_facility: Private Practice Dr MN Rajabally /ID# 223805

location_facility: Agaplesion Markus Krankenhaus /ID# 223673

location_facility: The Sixth Affiliated Hosp Sun /ID# 224416

location_facility: Hospital Universitario Virgen Macarena /ID# 223315


title: Consequences of Parenteral Nutrition Photoprotection on the Oxidant Related Diseases Among Extremely Low Birth Weight Infants : A Randomized Controlled Study

summary: The antioxidant system of very low birth weight infants is immature. This immaturity is implicated in the pathogenesis of diseases such as bronchopulmonary dysplasia or retinopathy. The main source of oxidant is oxygen, and parenteral nutrition is contaminated with oxidant. Photoprotection decreases the oxidant load infused with parenteral nutrition. In a preliminary study, photoprotection reduced the frequency of pulmonary bronchodysplasia, increased the quantity of enteral nutrition tolerated, and decreased the arterial blood pressure among very low birth weight infants. The aim of this study is to evaluate the impact of photoprotection on oxidant related diseases among very low birth weight infants. This study is a randomized multicenter trial. In the intervention group, photoprotection is applied until the infusion of parenteral nutrition with amber bags, tubing, and syringes. The quality of photoprotection is controlled by measuring malondialdehyde and cysteine after 24 hours of infusion. The control group will receive parenteral nutrition with transparent bags and tubing. The outcomes are evaluated at 36 weeks, and 680 infants will be enrolled, with stratification among centers and gestational age.

ReferenceType: result

ReferenceCitation: Laborie S, Denis A, Dassieu G, Bedu A, Tourneux P, Pinquier D, Kermorvant E, Millet V, Klosowski S, Patural H, Clamadieu C, Brunhes A, Walther M, Jaisson-Hot I, Mandy B, Claris O. Shielding Parenteral Nutrition Solutions From Light: A Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2015 Aug;39(6):729-37. doi: 10.1177/0148607114537523. Epub 2014 Jun 12.

name: Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Bron, France

name: Hospices Civils de Lyon-Centre Hospitalier Lyon Sud, Pierre-Bénite, France

family: Laborie

full_name: Sophie Laborie

given: Sophie

family: Denis

full_name: Angélique Denis

given: Angélique

name: Centre Hospitalier Intercommunal de Créteil, Créteil, France

family: Dassieu

full_name: Gilles Dassieu

given: Gilles

name: Centre Hospitalier Universitaire de Limoges, Limoges, France

family: Bedu

full_name: Antoine Bedu

given: Antoine

name: Centre Hospitalier Universitaire, Amiens, France

family: Tourneux

full_name: Pierre Tourneux

given: Pierre

name: Centre Hospitalier Universitaire–Hôpital Charles-Nicolle, Rouen, France

family: Pinquier

full_name: Didier Pinquier

given: Didier

name: Assistance Publique/Hôpitaux de Paris-Hôpital Necker-Enfants Malades, Paris, France

name: Université Paris Descartes, Paris, France

family: Kermorvant

full_name: Elsa Kermorvant

given: Elsa

name: Assistance Publique–Hôpitaux de Marseille–Hôpital de la Conception, Marseille, France

family: Millet

full_name: Véronique Millet

given: Véronique

name: Centre Hospitalier de Lens, Lens, France

family: Klosowski

full_name: Serge Klosowski

given: Serge

name: Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France

family: Patural

full_name: Hugues Patural

given: Hugues

family: Clamadieu

full_name: Catherine Clamadieu

given: Catherine

name: Hôpital de la Côte Basque, Bayonne, France

family: Brunhes

full_name: Anne Brunhes

given: Anne

name: Centre Hospitalier de Chambéry, Chambéry, France

family: Walther

full_name: Marie Walther

given: Marie

family: Jaisson-Hot

full_name: Isabelle Jaisson-Hot

given: Isabelle

name: Hospices Civils de Lyon, Hôpital René Sabran, Giens, France

family: Mandy

full_name: Bruno Mandy

given: Bruno

name: Université Claude Bernard Lyon 1, Lyon, France

family: Claris

full_name: Olivier Claris

given: Olivier

journal_name: Journal of Parenteral and Enteral Nutrition

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

lead_sponsor: Hospices Civils de Lyon

intervention_type: Device


title: Dietary Therapy of Mitochondrial Fatty Acids Oxidation. A Clinical Study of Treatment With Odd Carbons Medium-chain Fatty Acids

summary:
Usual dietary therapies of mitochondrial fatty acid oxidation disorders (FAO) are based on 3 strategies:

limitation of lipid intake in the diet;
supplementation of the diet with medium-chain triglycerides (MCT) for patients affected with disorders of long-chain FAO;
some specific supplementations (for example, L-carnitine).

These strategies are often ineffective. The aim of the present study is to evaluate new therapeutic ways based on the underlying energetic defect observed in these disorders. The long-term goal is to develop efficient therapies of these disorders.

lead_sponsor: Assistance Publique - Hôpitaux de Paris

location_facility: Necker University Hospital - Metabolism Unit


title: Young Adult With Acute Lymphoblastic Leukemia (ALL) : a Multicentric Protocol. GRAALL 2005 : T ALL or B ALL Non Ph GRAALL 2005 R : B ALL Non Ph CD20+ GRAAPH 2005 : ALL Ph

summary:
This study is a multicenter trial of treatment for young ALL patients. All ALL patients will receive the same steroid pre-phase in order to evaluate sensitivity or resistance. Then, patients will be included into 3 specific trials according to biological features (immunophenotype, cytogenetics, and molecular biology).

Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) 2005:

T ALL or B ALL non Ph (N=810 patients planned).
GRAALL 2005 R: B ALL non Ph CD20+ (N=220 patients planned).
GRAAPH 2005: ALL Ph+ (N=270 patients planned)

ReferenceCitation: Orvain C, Balsat M, Tavernier E, Marolleau JP, Pabst T, Chevallier P, de Gunzburg N, Cacheux V, Huguet F, Chantepie S, Caillot D, Chalandon Y, Frayfer J, Bonmati C, Lheritier V, Ifrah N, Dombret H, Boissel N, Hunault-Berger M. Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study. Blood. 2020 Jul 16;136(3):328-338. doi: 10.1182/blood.2020004919.

name: Angers University Hospital, Angers, France

family: Orvain

full_name: Corentin Orvain

given: Corentin

family: Balsat

full_name: Marie Balsat

name: Institut de cancérologie de la Loire, Saint Priest en Jarez, France

family: Tavernier

full_name: Emmanuelle Tavernier

given: Emmanuelle

family: Marolleau

full_name: Jean-Pierre Marolleau

given: Jean-Pierre

family: Pabst

full_name: Thomas Pabst

given: Thomas

family: Chevallier

full_name: Patrice Chevallier

given: Patrice

name: Versailles University Hospital, Le Chesnay, France

family: de Gunzburg

full_name: Noémie de Gunzburg

given: Noémie

name: Clermont-Ferrand Univeristy Hospital, Clermont-Ferrand, France

family: Cacheux

full_name: Victoria Cacheux

given: Victoria

name: Institut de Cancérologie de Toulouse, TOULOUSE, France

family: Rigal-Huguet

full_name: Françoise Rigal-Huguet

given: Françoise

family: Chantepie

full_name: Sylvain P Chantepie

given: Sylvain P

family: Caillot

full_name: Denis Caillot

given: Denis

name: University Hospital of Geneva, Geneva, Switzerland

family: Chalandon

full_name: Yves Chalandon

given: Yves

family: Frayfer

full_name: Jamilé Frayfer

given: Jamilé

name: Service d'Hématologie, Centre Hospitalier Universitaire de Nancy, Nancy, France

family: Bonmati

full_name: Caroline Bonmati

given: Caroline

name: Centre Hospitalier Lyon Sud, Pierre Bénite, France

family: Lheritier

full_name: Veronique Lheritier

given: Veronique

family: Ifrah

full_name: Norbert H Ifrah

given: Norbert H

family: Dombret

full_name: Hervé Dombret

given: Hervé

name: Hopital Saint-Louis, AP-HP, Paris, France

family: Boissel

full_name: Nicolas Boissel

given: Nicolas

family: Hunault-Berger

full_name: Mathilde M Hunault-Berger

given: Mathilde M

journal_name: Blood

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via free article)

host_type: publisher

license_normalized: no license

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: University of Geneva - Archive ouverte UNIGE

repositories_institution: University of Geneva - Archive ouverte UNIGE

publisher: American Society of Hematology

publisher_dissemination: American Society of Hematology

title: Thromboembolism Prophylaxis in Adult Patients with Acute Lymphoblastic Leukemia Treated in the GRAALL-2005 Study

ReferenceCitation: Touzart A, Boissel N, Belhocine M, Smith C, Graux C, Latiri M, Lhermitte L, Mathieu EL, Huguet F, Lamant L, Ferrier P, Ifrah N, Macintyre E, Dombret H, Asnafi V, Spicuglia S. Low level CpG island promoter methylation predicts a poor outcome in adult T-cell acute lymphoblastic leukemia. Haematologica. 2020 Jun;105(6):1575-1581. doi: 10.3324/haematol.2019.223677. Epub 2019 Sep 19.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - ENS-LYON

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - ENS-LYON

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

publisher: Ferrata Storti Foundation (Haematologica)

publisher_dissemination: Ferrata Storti Foundation (Haematologica)

publisher_group: Ferrata Storti Foundation (Haematologica)

publisher_normalized: Ferrata Storti Foundation (Haematologica)

ReferenceCitation: Bond J, Touzart A, Leprêtre S, Graux C, Bargetzi M, Lhermitte L, Hypolite G, Leguay T, Hicheri Y, Guillerm G, Bilger K, Lhéritier V, Hunault M, Huguet F, Chalandon Y, Ifrah N, Macintyre E, Dombret H, Asnafi V, Boissel N. DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia. Haematologica. 2019 Aug;104(8):1617-1625. doi: 10.3324/haematol.2018.197848. Epub 2019 Jan 17.

ReferenceCitation: Huguet F, Chevret S, Leguay T, Thomas X, Boissel N, Escoffre-Barbe M, Chevallier P, Hunault M, Vey N, Bonmati C, Lepretre S, Marolleau JP, Pabst T, Rousselot P, Buzyn A, Cahn JY, Lhéritier V, Béné MC, Asnafi V, Delabesse E, Macintyre E, Chalandon Y, Ifrah N, Dombret H; Group of Research on Adult ALL (GRAALL). Intensified Therapy of Acute Lymphoblastic Leukemia in Adults: Report of the Randomized GRAALL-2005 Clinical Trial. J Clin Oncol. 2018 Aug 20;36(24):2514-2523. doi: 10.1200/JCO.2017.76.8192. Epub 2018 Jun 4.

name: Françoise Huguet, Eric Delabesse, Institut Universitaire du Cancer, Toulouse; Sylvie Chevret, Nicolas Boissel, Hervé Dombret, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP); Université Paris Diderot; Agnès Buzyn, Vahid Asnafi, Elizabeth Macintyre, Hôpital Necker, AP-HP; Université Paris Descartes, Paris; Thibaut Leguay, Centre Hospitalier Universitaire, Pessac; Xavier Thomas, Véronique Lhéritier, Hôpital Lyon-Sud, Pierre Bénite; Martine Escoffre-Barbe, Centre Hospitalier Universitaire...

name: for the Group of Research on Adult ALL (GRAALL)

repository_institution: University Library Bern - BORIS - Bern Open Repository and Information System

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Hospices Civils de Lyon

publisher: American Society of Clinical Oncology (ASCO)

publisher_dissemination: American Society of Clinical Oncology (ASCO)

publisher_group: American Society of Clinical Oncology (ASCO)

publisher_normalized: American Society of Clinical Oncology (ASCO)

ReferenceCitation: Maury S, Chevret S, Thomas X, Heim D, Leguay T, Huguet F, Chevallier P, Hunault M, Boissel N, Escoffre-Barbe M, Hess U, Vey N, Pignon JM, Braun T, Marolleau JP, Cahn JY, Chalandon Y, Lhéritier V, Beldjord K, Béné MC, Ifrah N, Dombret H; for GRAALL. Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia. N Engl J Med. 2016 Sep 15;375(11):1044-53. doi: 10.1056/NEJMoa1605085.

title: Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia

ReferenceCitation: Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, Sutton L, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V. An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. Haematologica. 2016 Jun;101(6):732-40. doi: 10.3324/haematol.2015.141218. Epub 2016 Mar 4.

repositories_institution:
Imperial College London - Spiral
PubMed Central - Europe PMC

ReferenceCitation: Chalandon Y, Thomas X, Hayette S, Cayuela JM, Abbal C, Huguet F, Raffoux E, Leguay T, Rousselot P, Lepretre S, Escoffre-Barbe M, Maury S, Berthon C, Tavernier E, Lambert JF, Lafage-Pochitaloff M, Lhéritier V, Chevret S, Ifrah N, Dombret H; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL). Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia. Blood. 2015 Jun 11;125(24):3711-9. doi: 10.1182/blood-2015-02-627935. Epub 2015 Apr 15. Erratum in: Blood. 2015 Sep 3;126(10):1261.

name: Division of Hematology, Department of Medical Specialties, University Hospital and University of Geneva, Geneva, Switzerland;

name: Swiss Group for Clinical Cancer Research, Bern, Switzerland;

name: Division of Hematology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France;

name: Division of Hematology, Hôpital Saint-Louis, Assistance Publique–Hôpitaux de Paris, University Paris Diderot, Paris, France;

name: Division of Hematology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;

name: Division of Hematology, Institut Universitaire de Cancérologie, Toulouse, France;

name: Division of Hematology, Hôpital Haut-Levêque, Pessac, France;

name: Division of Hematology, Hôpital Mignot, Versailles, France;

name: Division of Hematology, Centre Henri Becquerel, Rouen, France;

name: Division of Hematology, Hôpital Pontchailloux, Rennes, France;

name: Division of Hematology, Hôpital Henri Mondor, Assistance Publique–Hôpitaux de Paris, University Paris Est Créteil, Créteil, France;

name: Division of Hematology, Hôpital Claude Huriez, Lille, France;

name: Division of Hematology, Institut de Cancérologie Lucien-Neuwirth, Saint-Priest-en-Jarez, France;

name: Division of Hematology, Hôpital de la Timone, Marseille, France;

name: Group for Research on Adult Acute Lymphoblastic Leukemia, Lyon, France;

name: Division of Biostatistics, Hôpital Saint-Louis, Assistance Publique–Hôpitaux de Paris, University Paris Diderot, Paris, France; and

name: Division of Hematology, Centre Hospitalier Universitaire d’Angers and INSERM U892/Centre National de la Recherche Scientifique 6299, Angers, France

ReferenceCitation: Chien WW, Catallo R, Chebel A, Baranger L, Thomas X, Béné MC, Gerland LM, Schmidt A, Beldjord K, Klein N, Escoffre-Barbe M, Leguay T, Huguet F, Larosa F, Hayette S, Plesa A, Ifrah N, Dombret H, Salles G, Chassevent A, Ffrench M. The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome. Leuk Res. 2015 Apr;39(4):453-61. doi: 10.1016/j.leukres.2015.01.008. Epub 2015 Jan 25.

title: The p16INK4A/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome

ReferenceCitation: Dhédin N, Huynh A, Maury S, Tabrizi R, Beldjord K, Asnafi V, Thomas X, Chevallier P, Nguyen S, Coiteux V, Bourhis JH, Hichri Y, Escoffre-Barbe M, Reman O, Graux C, Chalandon Y, Blaise D, Schanz U, Lhéritier V, Cahn JY, Dombret H, Ifrah N; GRAALL group. Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia. Blood. 2015 Apr 16;125(16):2486-96; quiz 2586. doi: 10.1182/blood-2014-09-599894. Epub 2015 Jan 13.

name: Department of Hematology and University Paris Diderot, Institut Universitaire d’Hématologie, EA-3518, University Hospital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France;

name: Department of Hematology, University Institute of Cancer, Toulouse, France;

name: Department of Hematology, University Hospital Henri Mondor, AP-HP, Créteil, France;

name: Department of Hematology, University Hospital, Bordeaux, France;

name: Department of Hematology, University Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades, INSERM U1151, and Onco-Hematology Laboratory, Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France;

name: Department of Hematology, Hospital Lyon Sud, Pierre Bénite, France;

name: Department of Hematology, University Hospital, Nantes, France;

name: Department of Hematology, University Hospital Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France;

name: Department of Hematology, University Hospital, Lille, France;

name: Department of Hematology, Institut Gustave Roussy, Villejuif, France;

name: Department of Hematology, University Hospital, Montpellier, France;

name: Department of Hematology, University Hospital, Rennes, France;

name: Department of Hematology, University Hospital, Caen, France;

name: Department of Hematology, University Hospital, Yvoir, Belgium;

name: Division of Hematology, Department of Medical Specialties, University Hospital, Geneva, and Faculty of Medicine, University of Geneva Switzerland and Swiss Group for Clinical Cancer Research, Bern, Switzerland;

name: Department of Hematology, Institut Paoli Calmettes, Marseille, France;

name: Division of Hematology, University Hospital of Zurich, Zurich, Switzerland;

name: Group for Research on Adult Acute Lymphoblastic Leukemia, Coordination Office, Pierre Bénite, France;

name: Department of Hematology, University Hospital, Grenoble, France; and

name: Department of Hematology and INSERM U 892/CNRS 6299, University Hospital, Angers, France

ReferenceCitation: Beldjord K, Chevret S, Asnafi V, Huguet F, Boulland ML, Leguay T, Thomas X, Cayuela JM, Grardel N, Chalandon Y, Boissel N, Schaefer B, Delabesse E, Cavé H, Chevallier P, Buzyn A, Fest T, Reman O, Vernant JP, Lhéritier V, Béné MC, Lafage M, Macintyre E, Ifrah N, Dombret H; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL). Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia. Blood. 2014 Jun 12;123(24):3739-49. doi: 10.1182/blood-2014-01-547695. Epub 2014 Apr 16.

name: Department of Biostatistics, University Paris Diderot, Institut Universitaire d’Hématologie, EA-3518 and UMR-S-717, University Hospital Saint-Louis, Assistance Publique – Hôpitaux de Paris, Paris, France;

name: Laboratory of Oncohematology, AP-HP, Hôpital Necker Enfants-Malades, University Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades, Institut National de Recherche Médicale U1151, Paris, France;

name: Department of Hematology, University Hospital Purpan, Toulouse, France;

name: Department of Hematology, University Hospital Haut-Lévèque, Bordeaux, France;

name: Department of Hematology, University Hospital Lyon Sud, Lyon, France;

name: Department of Hematology, University Hospital Claude Huriez, Lille, France;

name: Department of Hematology, University Hospital, Geneva, Switzerland;

name: Department of Hematology, University Hospital, Zürich, Switzerland;

name: Department of Hematology, University Hospital Robert Debré, Assistance Publique – Hôpitaux de Paris, Paris, France;

name: University Hospital Pitié-Salpêtrière, Assistance Publique – Hôpitaux de Paris, Paris, France;

name: GRAALL Coordination Office, University Hospital Lyon Sud, Lyon, France;

name: Department of Genetics, Aix-Marseille University, Marseille, France; and

name: Department of Hematology, University Hospital, INSERM U892/CNRS 6299, Angers, France

ReferenceCitation: Trinquand A, Tanguy-Schmidt A, Ben Abdelali R, Lambert J, Beldjord K, Lengliné E, De Gunzburg N, Payet-Bornet D, Lhermitte L, Mossafa H, Lhéritier V, Bond J, Huguet F, Buzyn A, Leguay T, Cahn JY, Thomas X, Chalandon Y, Delannoy A, Bonmati C, Maury S, Nadel B, Macintyre E, Ifrah N, Dombret H, Asnafi V. Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. J Clin Oncol. 2013 Dec 1;31(34):4333-42. doi: 10.1200/JCO.2012.48.5292. Epub 2013 Oct 28.

name: Amélie Trinquand, Raouf Ben Abdelali, Etienne Lengliné, Noémie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agnès Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR)-8147, and Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades; Jérôme Lambert, UMR-S-717, Hôpital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lengliné, and Hervé Dombret, University Paris 7, Hôpital Saint...

title: Toward a NOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study

ReferenceCitation: Ben Abdelali R, Asnafi V, Petit A, Micol JB, Callens C, Villarese P, Delabesse E, Reman O, Lepretre S, Cahn JY, Guillerm G, Berthon C, Gardin C, Corront B, Leguay T, Béné MC, Ifrah N, Leverger G, Dombret H, Macintyre E. The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest. Haematologica. 2013 Nov;98(11):1711-7. doi: 10.3324/haematol.2013.086082. Epub 2013 Jul 5.

location_facility: Group for Research in Adult Acute Lymphoblastic Leukemia - GRAALL -


title: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Subjects With Extensive Stage Small Cell Lung Cancer (MERU)

acronym: MERU

summary: This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based chemotherapy.

ReferenceCitation: Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, Nakanishi Y, Okamoto I. Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. Lung Cancer. 2018 Jan;115:116-120. doi: 10.1016/j.lungcan.2017.11.018. Epub 2017 Nov 22.

family: Tanaka

full_name: Kentaro Tanaka

given: Kentaro

family: Isse

full_name: Kumiko Isse

given: Kumiko

family: Fujihira

full_name: Tomomichi Fujihira

given: Tomomichi

family: Takenoyama

full_name: Mitsuhiro Takenoyama

given: Mitsuhiro

family: Saunders

full_name: Laura Saunders

given: Laura

family: Bheddah

full_name: Sheila Bheddah

given: Sheila

family: Nakanishi

full_name: Yoichi Nakanishi

given: Yoichi

family: Okamoto

full_name: Isamu Okamoto

given: Isamu

journal_name: Lung Cancer

location_country:
Finland
Greece
Australia
Belgium
Russian Federation
Denmark
Taiwan
Ukraine
Spain
Croatia
France
Japan
Lithuania
Poland
Norway
Canada
Korea, Republic of
Turkey
South Africa
Sweden
Hong Kong
Netherlands
Switzerland
Bulgaria
Hungary
Ireland
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Serbia
Mexico
Czechia
Israel
Belarus
Estonia
Latvia

location_facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159659

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 202409

location_facility: Akershus universitetssykehus /ID# 201682

location_facility: Southeastern Regional Medical /ID# 163064

location_facility: VA Pittsburgh HealthcareSystem /ID# 159284

location_facility: Municipal institution Multifie /ID# 159130

location_facility: Hospital Clinico Universitario Lozano Blesa /ID# 159709

location_facility: University Hospital Limerick /ID# 159714

location_facility: Kansai Medical University Hospital /ID# 165054

location_facility: National Cheng Kung University Hospital /ID# 158799

location_facility: Cancercare Langenhoven Drive Oncology Centre /ID# 159126

location_facility: Cancer Specialists of North Florida - Southpoint /ID# 156595

location_facility: Volyn Regional Medical Oncology Centre /ID# 159133

location_facility: Univ Medical Ctr Brackenridge /ID# 155798

location_facility: St Vincent's University Hosp /ID# 161678

location_facility: Taipei Veterans General Hosp /ID# 203699

location_facility: Istanbul Medeniyet Universites /ID# 200126

location_facility: St Jude Hospital dba St Joseph /ID# 156526

location_facility: Akdeniz Universitesi Tip Fakul /ID# 160791

location_facility: Kanazawa University Hospital /ID# 165127

location_facility: Charite Universitatsmedizin Berlin Campus Virchow Klinikum /ID# 158783

location_facility: Metropolitan General Hospital /ID# 202422

location_facility: Ospedale Santa Maria delle Cro /ID# 158911

location_facility: Asklepios Fachkliniken M. Gaut /ID# 158789

location_facility: IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 160898

location_facility: Szpitale Pomorskie Sp. z o.o /ID# 159605

location_facility: Houston Methodist Hospital - Scurlock Tower /ID# 202323

location_facility: Parkland Health and Hosp Syste /ID# 170933

location_facility: R.S. McLaughlin Durham Regional /ID# 170870

location_facility: Liga Norte Rio Grandense Cont. /ID# 159011

location_facility: Yokohama City University Hospital /ID# 165746

location_facility: National Cancer Center Hospital /ID# 166547

location_facility: NorthShore University HealthSystem - Evanston Hospital /ID# 156664

location_facility: Duke University Medical Center /ID# 156706

location_facility: Institute For Pulmonary Diseas /ID# 164250

location_facility: Stony Brook University Hospital /ID# 159272

location_facility: Universitair Medisch Centrum Utrecht /ID# 158083

location_facility: Odense Universitets Hospital /ID# 158054

location_facility: CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159131

location_facility: National Cancer Center Hospital East /ID# 165721

location_facility: N.N. Petrov Research Inst Onc /ID# 159370

location_facility: Hospital Clinico Universitario San Carlos /ID# 159706

location_facility: Cancercare Outeniqua Oncology Unit /ID# 200689

location_facility: Mogilev Reg Clin Oncology Dis /ID# 159384

location_facility: UT Southwestern Medical Center /ID# 157848

location_facility: North Estonian Medical Centre /ID# 159779

location_facility: Affinity Clinical Research Ser /ID# 158887

location_facility: Tennessee Oncology-Nashville Centennial /ID# 161168

location_facility: East Tallinn Central Hospital /ID# 160019

location_facility: Gabrail Cancer Center Research /ID# 156667

location_facility: British Columbia Cancer Agency /ID# 163721

location_facility: State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159383

location_facility: General Oncological Hospital /ID# 159159

location_facility: Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 159604

location_facility: Hospital Teresa Herrera - CHUAC /ID# 164368

location_facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 159693

location_facility: Hopitaux Universitaires de Geneve /ID# 160603

location_facility: Thompson Cancer Survival Ctr /ID# 202460

location_facility: Institut za onkologiju i radio /ID# 160904

location_facility: Krankenhaus Nord - Klinik Floridsdorf /ID# 201768

location_facility: Centro Hospitalar do Porto EPE /ID# 203582

location_facility: Smolensk Regional Onc Clin Dis /ID# 159372

location_facility: Haukeland University Hospital /ID# 159573

location_facility: Hospital Parc de Salut del Mar /ID# 159690

location_facility: Calvary North Adelaide Hospita /ID# 161701

location_facility: Hacettepe University Medical Faculty /ID# 159242

location_facility: Orszagos Koranyi Pulmonologiai Intezet /ID# 158953

location_facility: Klinika za plucne bolesti Jordanovac /ID# 159505

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz - Pulmonologia /ID# 202466

location_facility: Dr Albert, Bouwer and Jordaan Incorporated /ID# 158873

location_facility: Bezmi alem Vakif Universitesi /ID# 202267

location_facility: Ashland-Bellefonte Cancer Ctr /ID# 202901

location_facility: Associação Hospital de Caridade Ijuí - Centro de Tratamento de Cancer - CACON /ID# 159013

location_facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 159090

location_facility: Dalin Tzu Chi General Hospital /ID# 158983

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159160

location_facility: Centro de Investigación Clinica Chapultepec /ID# 160965

location_facility: Tri-Service General Hospital /ID# 158980

location_facility: Kanagawa Cardiovascular and Respiratory Center /ID# 165015

location_facility: Maastricht Universitair Medisch Centrum /ID# 161669

location_facility: Bobruysk Interdistrict Onco. /ID# 169393

location_facility: Goshen Center for Cancer Care /ID# 156682

location_facility: 4th Military Medical Universit /ID# 203986

location_facility: Assaf Harofeh Medical Center /ID# 201883

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 158798

location_facility: Palo Alto Veterans Institute for Research /ID# 203695

location_facility: Windsor Regional Cancer Centre /ID# 170869

location_facility: First Affiliated Hospital of Xi'an Jiaotong University /ID# 203733

location_facility: Tokushima University Hospital /ID# 166105

location_facility: National Medical Research Cntr /ID# 169885

location_facility: Csongrad Megyei Mellkasi Beteg /ID# 158952

location_facility: Evangelische Lungenklinik Berl /ID# 158935

location_facility: Sparrow Regional Cancer Center, Sparrow Health System /ID# 156590

location_facility: Thoraxklinik Heidelberg gGmbH /ID# 158871

location_facility: Chungbuk National University /ID# 159300

location_facility: Klinicki bolnicki centar Rijeka /ID# 159504

location_facility: AUSL 8 Arezzo Ospedale San Don /ID# 160897

location_facility: University of Florida - Archer /ID# 155799

location_facility: St. Luke's Mountain States Tumor Institute - Boise /ID# 156691

location_facility: Hospital Evangelico de Cachoei /ID# 159657

location_facility: Ege University Medical Faculty /ID# 159243

location_facility: Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159012

location_facility: Hospital Universitario La Paz /ID# 159692

location_facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 165543

location_facility: Harbin Medical University Cancer Hospital /Id# 203638

location_facility: University Hospital of Ioannin /ID# 159158

location_facility: Northwell Health - Monter Cancer Center /ID# 159252

location_facility: The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203641

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 159044

location_facility: The Royal Bournemouth Hospital /ID# 159039

location_facility: Fujian Provincial Cancer Hospital /ID# 204864

location_facility: SMZ Baumgartner Höhe, Otto-Wagner-Spital und Pflegezentrum /ID# 201776

location_facility: Queen Elizabeth Medical Centre /ID# 162899

location_facility: West Virginia Univ School Med /ID# 156687

location_facility: Arkhangelsk clinical oncology /ID# 159367

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 160016

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 159638

location_facility: China Medical University Hosp /ID# 158981

location_facility: Erciyes University Medical Fac /ID# 202269

location_facility: Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 159864

location_facility: Nemocnice Rudolfa a Stefanie /ID# 159655

location_facility: University Hospital Waterford /ID# 159713

location_facility: Salzburger Landeskliniken (SALK) /ID# 201779

location_facility: Aichi Cancer Center Hospital /ID# 164976

location_facility: Christie NHS Foundation Trust /ID# 159037

location_facility: Kaluga Regional Clinical Oncol /ID# 160180

location_facility: Stavanger Universitetssykehus /ID# 159575

location_facility: University Hospital Linkoping /ID# 159046

location_facility: Torbay Hospital - So Devon HC /ID# 159041

location_facility: Nebraska Hematology Oncology /ID# 156534

location_facility: Riga East Clinical University /ID# 158716

location_facility: Tel Aviv Sourasky Medical Center /ID# 161467

location_facility: Christiana Care Health Service /ID# 159212

location_facility: Icahn School of Med Mt. Sinai /ID# 159210

location_facility: CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 158962

location_facility: Japanese Red Cross Okayama Hospital /ID# 165157

location_facility: CHA Bundang Medical center CHA University /ID# 161281

location_facility: Korea University Guro Hospital /ID# 159302

location_facility: Centre Hosp Intercommunal de Creteil /ID# 162686

location_facility: Health Pharma professional Ser /ID# 160734

location_facility: Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159865

location_facility: Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159658

location_facility: Sarah Cannon Research Institute-Chattanooga /ID# 202933

location_facility: Kyungpook National University Chilgok Hospital /ID# 159301

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 160903

location_facility: Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159661

location_facility: Klaipeda University Hospital /ID# 160018

location_facility: OOO Centre of Palliative Medicine De Vita /ID# 206855

location_facility: Taichung Veterans General Hosp /ID# 159047

location_facility: Wojewodzki Szpital Specjalisty /ID# 159603

location_facility: Unidade Local Saude Matosinhos /ID# 159950

location_facility: MD Anderson Cancer Center at Cooper - Camden /ID# 156681

location_facility: Hospital Universitario Vall d'Hebron /ID# 159708

location_facility: Policlinico Universitario Campus Bio-Medico /ID# 160874

location_facility: IFO Istituto Nazionale Tumori /ID# 158912

location_facility: Soroka University Medical Center /ID# 159762

location_facility: National Hospital Organization Himeji Medical Center /ID# 165899

location_facility: Centro Hospitalar Lisboa Norte, EPE /ID# 159957

location_facility: Ordensklinikum Linz GmbH, Elisabethinen /ID# 159564


title: Global Multicentre Kidney Transplant Advagraf Conversion Registry. A Non-interventional Post-authorisation Study (PAS)

acronym: CHORUS

summary: A study to evaluate changes over time in renal function from baseline (time of conversion) up until five years post conversion in kidney transplant patients converted from tacrolimus twice daily (BD) formulations to a once daily formulation as Advagraf.

status: Active, not recruiting

ipd_sharing_description: Access to anonymized individual participant level data will not be provided for this trial as it meets one or more of the exceptions described on www.clinicalstudydatarequest.com under "Sponsor Specific Details for Astellas."

lead_sponsor: Astellas Pharma Europe Ltd.

location_country:
Malaysia
Greece
Romania
Australia
Belgium
Taiwan
France
Japan
Poland
Thailand
Canada
Korea, Republic of
Hong Kong
Netherlands
Philippines
Vietnam
Hungary
Portugal
Germany
United Kingdom
Italy
Austria
Serbia
Czechia
Spain

location_facility:
Site FR3306
Site IT3910
Site FR3311
Site JP8105
Site VN8402
Site KR8204
Site KR8216
Site KR8211
Site CZ4202
Site IT3915
Site PH6303
Site AU6107
Site KR8207
Site AU6103
Site AU6105
Site JP8108
Site IT3911
Site KR8210
Site KR8218
Site TW8862
Site GB4405
Site SB3802
Site IT3908
Site SB3801
Site KR8213
Site IT3913
Site ES3403
Site KR8206
Site FR3323
Site FR3312
Site TW8863
Site JP8111
Site FR3325
Site KR8202
Site GR3004
Site IT3909
Site AT4301
Site FR3319
Site GB4407
Site FR3313
Site KR8203
Site TH6603
Site KR8201
Site JP8107
Site GB4402
Site FR3302
Site KR8208
Site FR3322
Site KR8215
Site IT3901
Site PL4806
Site FR3314
Site JP8102
Site CA1001
Site JP8106
Site JP8110
Site GB4406
Site FR3308
Site AU6104
Site NL3101
Site MY6001
Site JP8109
Site DE4901
Site JP8104
Site AU6110
Site IT3914
Site NL3104
Site PT3511
Site IT3907
Site GR3002
Site AU6106
Site FR3303
Site AU6108
Site DE4903
Site IT3905
Site GB4408
Site BE3201
Site PL4801
Site FR3321
Site SB3804
Site KR8209
Site HU3602
Site FR3305
Site HK8521
Site VN8401
Site RO4002
Site AT4304
Site KR8214
Site TH6602
Site FR3301
Site FR3309
Site AU6111
Site FR3315
Site JP8101
Site IT3902
Site IT3903
Site IT3906
Site ES3410
Site KR8219
Site NL3105
Site FR3316
Site HU3601
Site GB4401
Site PL4808
Site HK8201
Site PL4807
Site IT3904
Site SB3803
Site KR8212
Site RO4003
Site DE4902
Site NL3103
Site ES3401
Site AT4302
Site IT39013
Site RO4001
Site TH6601
Site TW8861
Site RO4004
Site FR3317
Site FR3310
Site KR8205
Site FR3324
Site FR3318
Site IT3912
Site GB4403
Site IT3916
Site FR3307
Site AT4303


type: Registry Identifier

title: PARALLEL 303: A Phase 2, Double-blind, Randomized Study of BGB-290 Versus Placebo as Maintenance Therapy in Patients With Inoperable Locally Advanced or Metastatic Gastric Cancer That Responded to Platinum-based First-line Chemotherapy

summary: This study will enroll participants with previously-treated advanced or inoperable gastric cancer who have responded to first line platinum therapy into two treatment arms. In Arm A participants will receive BGB-290; in Arm B participants will receive placebo. The purpose of this study is to show that BGB-290 (versus placebo) will improve progression-free survival (PFS) in participants with advanced or inoperable gastric cancer.

lead_sponsor: BeiGene

location_country:
Hong Kong
Spain
France
Czechia
Japan
Poland
Georgia
Romania
Hungary
Belgium
Australia
Russian Federation
China
Singapore
United States
United Kingdom
Taiwan

location_facility: Samara Regional Clinical Oncology Dispensary :

location_facility: Hyogo College of Medicine College Hospital

location_facility: Ballarat Oncology and Haematology Services

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: GBUZ "Regional clinical oncologic dispensary of Volgograd"

location_facility: 1st Affiliated Hospital of Nanjing Medical U

location_facility: Japan Community Health Care Organization (JCHO) Kyushu Hospital - Hospital

location_facility: Szpital Specjalist. w Brzozowie,Podkarpacki Ośrodek Onkologi

location_facility: AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology

location_facility: Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór

location_facility: Liaoning Cancer Hospital & Institute - Medical Oncology

location_facility: The Second Affiliated Hospital of Zhejiang University

location_facility: Northern Jiangsu people's hospital - Oncology

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: Hôpital Privé des Côtes d'Armor - Service oncologie

location_facility: GBOU VPO NorthWestern State Medical University n.a. I.I. Mec

location_facility: Sun Yat-sen University - Cancer Center (SYSUCC)

location_facility: Hospital Universitario Fundación Jiménez Díaz

location_facility: Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendeloint

location_facility: Hospital Universitario Fundacion Alcorcon

location_facility: Oregon Health and Science University Knight Cancer Institute - Hematology Medical Oncology - Hematology Medical Oncology

location_facility: The Second Affiliated Hospital of Soochow University

location_facility: Novant Health & Presbyterian Healthcare - Presbyterian Hospi

location_facility: The Sixth Affiliated Hospital of Sun Yat-sen University

location_facility: Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli

location_facility: The Affiliated Hospital Of Qingdao University

location_facility: Clinical Research Center Sp. z o.o., Medic-R Sp. K.

location_facility: The First Affiliated Hospital of Xinxiang Medical University

location_facility: Cancer Hospital of Shantou University Medical College - Oncology

location_facility: Osaka International Cancer Institute - Medical Oncology

location_facility: National Hospital Organization - Osaka National Hospital

location_facility: Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

location_facility: Scientific Research Center of Oncology LTD

location_facility: Guy's and St Thomas NHS Foundation Trust

location_facility: Anhui Medical University - The Second Hospital

location_facility: Peterborough And Stamford Hospitals - Haematology & Oncology

location_facility: CHU de Liège - Domaine Universitaire du Sart Tilman

location_facility: The Affiliated Hospital of Xuzhou Medical University

location_facility: Florida Cancer Specialists - Hematology/Oncology

location_facility: NHS - Guy's & St Thomas' Hospital - Medical Oncology

location_facility: Aichi Cancer Center Hospital - Clinical Oncology

location_facility: Spitalul Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta

location_facility: Tri-Service General Hospital - Neihu Branch - Hematology

location_facility: The First Affiliated Hospital of Anhui Medical University

location_facility: Baptist Health Medical Group Oncology, LLC - Research Center

location_facility: LTD Acad.F.Todua Medical Center -Research Institute of Clinical Medicine

location_facility: The Townsville Hospital and Health Service

location_facility: The First Affiliated Hospital of Xiamen University

location_facility: N.N. Petrov Research Institute of Oncology

location_facility: St. Marianna University School of Medicine Hospital

location_facility: AZ Maria Middelares - Campus Maria Middelares

location_facility: The first affiliated hospital of Zhengzhou University - Oncology - Oncology

location_facility: Beijing Cancer Hospital - Digestive Tumor Medical

location_facility: Nottingham University Hospitals NHS Trust

location_facility: Multiprofile Clinic Consilium Medulla LTD

location_facility: Vanderbilt University Medical Center (VUMC)

location_facility: Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital

location_facility: Osaka University Hospital - Medical Oncology

location_facility: Harbin Medical University Cancer Hospital - Oncology