title: Multi-Country Prospective ObserVAtionaL, Cohort Study of Patients With Moderate to Severe Chronic PlaqUE Psoriasis (VALUE)

acronym: VALUE

summary: This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.

ipd_sharing: Undecided

lead_sponsor: AbbVie

location_country:
Italy
Austria
United Arab Emirates
Saudi Arabia
Switzerland
Mexico
Netherlands
Germany
France
Czechia
Japan
Poland
Romania
Hungary
Argentina
Australia
Spain
Canada
United Kingdom
Colombia

location_facility: Kansai Medical University Hospital /ID# 213388

location_facility: Brinkmann & Partner, Gladbeck, /ID# 214247

location_facility: Duplicate_Praxis Dres. Kloss/Peterburgskiy /ID# 213960

location_facility: Hamilton Health Sciences Corporation /ID# 214053

location_facility: Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 213482

location_facility: ASST Spedali civili di Brescia /ID# 218717

location_facility: Kingston Hospital NHS Foundation Trust /ID# 215973

location_facility: RM Pharma Specialists S.A de C.V /ID# 225458

location_facility: Hôpital d'Instruction des Armées Sainte-Anne /ID# 218888

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 213670

location_facility: Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 224743

location_facility: Radboud Universitair Medisch Centrum /ID# 213592

location_facility: KKing Abdulaziz Medical City- National Guard Hospital /ID# 224354

location_facility: Hospital Universitario 12 de Octubre /ID# 238474

location_facility: Studiengesellschaft an der Hase GbR Praxis Weyergraf/Frick/Heiber /ID# 214466

location_facility: Praxis fuer Innere Medizin/Rheumatologie /ID# 213653

location_facility: Kingsway Dermatology & Aesthetics /ID# 217616

location_facility: Università degli Studi di Firenze /ID# 221383

location_facility: Hospital Universitario Austral /ID# 217540

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 215479

location_facility: Jichi Medical University Hospital /ID# 213403

location_facility: Dr Melinda Gooderham Medicine Professional Corporation /ID# 212133

location_facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 216663

location_facility: Matsuyama Red Cross Hospital /ID# 224745

location_facility: Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 218558

location_facility: King Saud University Med City /ID# 219065

location_facility: Grupo Clinico Catei Sociedad Civil /Id# 216978

location_facility: Hospital Clinico Universitario de Salamanca /ID# 225078

location_facility: Hospital General de Mostoles /ID# 225088

location_facility: Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 212960

location_facility: Fakultni nemocnice Hradec Kralove /ID# 222670

location_facility: Medizinische Universitaet Wien /ID# 216138

location_facility: CMS3 Company for Medical Study /ID# 213676

location_facility: CHU Amiens-Picardie Site Sud /ID# 216170

location_facility: Labderm S.C. Beata Bergler-Czop, Barbara Sido-Bergler /Id# 225447

location_facility: CH Annecy Genevois Site Annecy /ID# 225786

location_facility: Al-Mohammedi Medicine Professional Corporation /ID# 215408

location_facility: Breitsprecher, Osnabrueck, DE /ID# 213672

location_facility: Cambridge University Hospitals NHS Foundation Trust /ID# 215972

location_facility: Nemocnice Ceske Budejovice a.s. /ID# 216310

location_facility: Praxis Dres. Bornemann/Reinerth /ID# 213368

location_facility: Waldhotel Health & Medical Excellence /Id# 212743

location_facility: CHR Metz-Thionville - Hopital Bel-Air /ID# 225691

location_facility: St.Luke's International Hospital /ID# 213392

location_facility: Clinica Los Arcos Iztapalapa /Id# 216982

location_facility: Azienda Ospedaliera Universitaria Mater Domini- Campus Salvatore Venuta /ID# 218902

location_facility: Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 213444

location_facility: Praxis Dr. Konstantin Ertner /ID# 213640

location_facility: CHU de Rennes - PONTCHAILLOU /ID# 218248

location_facility: Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 213389

location_facility: Centre Hospitalier de CHAMBERY /ID# 217572

location_facility: Ospedale Fiorini di Terracina /ID# 218557

location_facility: Hospital Alvaro Cunqueiro CHUVI /ID# 225077

location_facility: Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 218845

location_facility: The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 215476

location_facility: Fondazione PTV Policlinico Tor Vergata /ID# 219031

location_facility: SimcoDerm Medical and Surgical Dermatology Center /ID# 213081

location_facility: Centre de Recherche St-Louis /ID# 216325

location_facility: Ospedale Policlinico San Martino /ID# 218844

location_facility: Centro Dermatologico Del Country S de Rl de Cv /Id# 225460

location_facility: Universitaetsklinikum Erlangen /ID# 213669

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 212958

location_facility: Sanatorium profesora Arenbergera /ID# 215489

location_facility: Azienda Ospedaliera Universitaria Federico II /ID# 218808

location_facility: University of the Ryukyus Hospital /ID# 213394

location_facility: Imperial College Healthcare NHS Trust /ID# 215978

location_facility: CHU Grenoble - Hopital Michallon /ID# 218437

location_facility: Emiliano Baccarini Priv Practice /ID# 218581

location_facility: Weihe/Stavermann, Berlin, DE /ID# 214550

location_facility: University Hospital Kyoto Prefectural University of Medicine /ID# 213396

location_facility: Universitaetsklinikum Hamburg-Eppendorf (UKE) /ID# 222464

location_facility: Hospital Universitario de Bajadoz /ID# 225091

location_facility: Inselspital, Universitätsspital Bern /ID# 212741

location_facility: Hospital Universitario Miguel Servet /ID# 225080

location_facility: Fujita Health University Hospital /ID# 224742

location_facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 218718

location_facility: COPERNICUS Podmiot Leczniczy Sp. z o.o. - Szpital sw. Wojciecha Adalberta /ID# 225446

location_facility: Instituto de Neumonología y Dermatología /ID# 217429

location_facility: Hospital Universitario del Sureste /ID# 226561

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 218720

location_facility: Markusovszky Egyetemi Oktatokorhaz /ID# 212961

location_facility: Frimley Health NHS Foundation Trust /ID# 215976

location_facility: Niakosari Medicine Professional Corporation /ID# 213486

location_facility: Private Office Cristina Echeverria /ID# 222082

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 212959

location_facility: Hospital General Universitario Gregorio Maranon /ID# 231664

location_facility: CEDIC Centro de Investigaciones Clinicas /ID# 217184

location_facility: Hopital de la Cavale Blanche /ID# 216495

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 225415

location_facility: Hospital Universitario Severo Ochoa /ID# 225087

location_facility: Hospital Clinico Universitario Lozano Blesa /ID# 231663

location_facility: Sociedad de Cirugía de Bogotá- Hospital de San José /ID# 222683

location_facility: Takamatsu Red Cross Hospital /ID# 222875

location_facility: Hôpital d'instruction des armées Bégin /ID# 216167

location_facility: Angela Montgomery Medicine Professional Corporation /ID# 213615

location_facility: Azienda Ospedaliera di Padova /ID# 221299

location_facility: DermaKiel Allergie und Haut Centrum /ID# 213977

location_facility: Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 218801

location_facility: Hospital Virgen de la Concha /ID# 233285

location_facility: Presidio Ospedaliero San Salvatore /ID# 218719

location_facility: Nippon Medical School Hospital /ID# 213391

location_facility: Haut. Venen. Allergie. Zentrum Brunnehof /ID# 212742

location_facility: CH Bigorre - Site de la Gespe /ID# 218563

location_facility: University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 213507

location_facility: Lima's Excellence in Allergy and Dermatology Research Inc /ID# 231973

location_facility: AP-HP - Hopital Bichat - Claude-Bernard /ID# 218436

location_facility: Praxis Dres. Ziegler & Partner /ID# 213647

location_facility: Dr Maksym Breslavets Medicine Professional Corporation /ID# 213338

location_facility: The Dudley Group NHS Foundation Trust /ID# 215839

location_facility: The Jikei University Hospital /ID# 213393

location_facility: Psoriahue Med Interdisciplinar /ID# 217182

location_facility: AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 218546

location_facility: Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 216979

location_facility: Universitatsklinikum Mannheim /ID# 214569

location_facility: CHU de CAEN - Hopital de la Cote de Nacre /ID# 216245

location_facility: Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 213113

location_facility: Hospital Universitario Virgen de las Nieves /ID# 225107

location_facility: Neki Servicios Medicos Profesionales S D Rl de Cv /Id# 216977

location_facility: Klinikum Wels-Grieskirchen GmbH /ID# 216140

location_facility: IRCCS Istituto Ortopedico Galeazzi /ID# 218867

location_facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz /ID# 222025

location_facility: Hospital Universitario de Puerto Real /ID# 225103

location_facility: Nagoya City University Hospital /ID# 213363

location_facility: Northern Care Alliance NHS Group /ID# 218589

location_facility: Dlugosz-Wolf, Luedenscheid, DE /ID# 222000

location_facility: Azienda Ospedaliero Universitaria Pisana-Stabilimento di Santa Chiara /ID# 218555

location_facility: Farheen Mussani Medicine Professional Corporation /ID# 213811

location_facility: Hospital Universitario Principe de Asturias /ID# 225085

location_facility: Spitalul Clinic Judetean de Urgenta Sf. Spiridon Iasi /Id# 214335

location_facility: Praxis Dres. Kaspari /Schenck /ID# 213649

location_facility: NewLab Clinical Research Inc. /ID# 213521

location_facility: Hospital Universitario Ramon y Cajal /ID# 225093

location_facility: Hospital Universitario de Getafe /ID# 225086

location_facility: Universitaetsklinikum Magdeburg /ID# 215080

location_facility: IRCCS Policlinico San Donato /ID# 222002

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 225084

location_facility: Centro Dermatológico Federico Lleras Acosta E.S.E /ID# 222686

location_facility: Asahikawa Medical University Hospital /ID# 213409

location_facility: South Eastern Health and Social Care Trust /ID# 215477

location_facility: A.O.U. Policlinico G. Rodolico S.Marco- Presidio G.Rodolico /ID# 219032

location_facility: Azienda Ospedaliera di Perugia /ID# 219033

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 225076

location_facility: Fundacion hospitalaria San Vicente de Paul /ID# 222680

location_facility: CH Pontoise - Hopital René Dubos /ID# 216169

location_facility: Fundacion Hospital Universidad del Norte /ID# 223428

location_facility: Cwm Taf Morgannwg University Health Board /ID# 215974


type: Other Identifier

title: Biomarker Study to Identify Subjects With Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations

summary: The purpose of this non-interventional study is to identify participants with urothelial cancer (UC) and selected fibroblast growth factor receptor (FGFR) aberrations through molecular testing of their archival tumor tissue.

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

study_type: Observational

time_perspective: Prospective

enrollment_type: Anticipated

lead_sponsor: Janssen Research & Development, LLC

location_country:
Italy
Brazil
Germany
France
Japan
Israel
Belgium
Argentina
Russian Federation
Spain
Turkey
United States
United Kingdom
Ukraine

location_facility: Polo Ospedaliero Unico Integrato- Presidio S.Camillo De Lellis Di Rieti

location_facility: Haydarpasa Numune Training and Research Hospital

location_facility: Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval

location_facility: National Hospital Organization Sagamihara National Hospital

location_facility: Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico

location_facility: State Budgetary Healthcare Institution Inter-regional Multi-specialty Hospital

location_facility: Diakonie-Klinikum Stuttgart - Diakonissenkrankenhaus und Paulinenhilfe gGmbH

location_facility: SHI Sverdlovsk Regional Clinical Hospital #1

location_facility: Associação Mário Penna/Núcleo de Ensino e Pesquisas

location_facility: National Hospital Organization Mito Medical Center

location_facility: Canakkale Onsekiz Mart University Health Practices and Research Hospital

location_facility: Yaroslavl Regional Clinical Oncology Hospital

location_facility: State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center

location_facility: Santa Casa de Misericordia de Belo Horizonte

location_facility: GBUZ City clinical hospital No. 29. N. E. Bauman

location_facility: SCMI Santa Casa de Misericórdia de Itabuna

location_facility: Kartal Dr. Lutfi Kirdar Egitim ve Arastirma Hastanesi

location_facility: Consultants in Medical Oncology and Hematology, P.C. - Abington

location_facility: Azienda Ospedaliera Ospedale San Carlo Borromeo

location_facility: Oncology Medical Clinics AV Medical group

location_facility: Hospital SS Annunziata - University G.D'Annunzio

location_facility: Cepeville - Centro de Hematologia e Oncologia

location_facility: Ryazan State Medical University named after I.P.Pavlov

location_facility: Communal Institution of Ternopil Regional Council 'Ternopil Regional Oncology Center'

location_facility: ME 'Poltava Regional Clinical Hospital n.a. M.V. Sklifosovsky of the Poltava Regional Council'

location_facility: Irmandade da Santa Casa de Misericordia de Porto Alegre

location_facility: N.A. Lopatkin Research Institute of Urology and Interventional Radiology

location_facility: Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal

location_facility: Instituto SENSUMED de Ensino e Pesquisa - Ruy França

location_facility: Medical Oncology Hematology Consultants, PA

location_facility: Necmettin Erbakan University Meram Medical Faculty

location_facility: Centro de Pesquisas do Hospital Amaral Carvalho

location_facility: Saint-Petersbutg state healthcare institution Saint Luke's clinical hospital

location_facility: National Hospital Organization Osaka National Hospital

location_facility: Az. USL 12 di Viareggio Ospedale Versilia

location_facility: Ospedale Buccheri La Ferla Fatebenefratelli

location_facility: National Hospital Organization Osaka Minami Medical Center

location_facility: Adnan Menderes University Training and Research Hospital

location_facility: Dr.Abdurrahman Yurtaslan Oncology Training and Research Hospital

location_facility: Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

location_facility: CHU de Liège - Domaine Universitaire du Sart Tilman

location_facility: Azienda Ulss 8 Berica- Ospedale Di Vicenza

location_facility: Willamette Valley Cancer Institute and Research Center

location_facility: SUBARU Health Insurance Society Ota Memorial Hospital

location_facility: Centre Hospitalier Eure-Seine - Hopitaux d'Evreux - Vernon

location_facility: Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council

location_facility: Communal Nonprofit Enterprise 'Regional Clinical Oncology Center of Kirovohrad Regional Council'

location_facility: Izmir Katip Celebi University Ataturk Training and Research Hospital

location_facility: Instituto de Oncologia de Sorocaba/Onco Clinicas Especializadas

location_facility: Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council

location_facility: Groupe Hospitalier Diaconesses Croix Saint Simon

location_facility: IRPCC - Instituto Ribeiraopretano de Combate ao Cancer

location_facility: Azienda Ospedaliera "Ospedale Civile" di Vimercate - Ospedal

location_facility: Azienda Ulss 6 Euganea- Ospedale Di Camposampiero

location_facility: Texas Oncology-Midland Allison Cancer Center

location_facility: Azienda Ospedaliera Universitaria Federico II

location_facility: Municipal Non-profit enterprise 'Bukovinian clinical oncology center'

location_facility: Tomsk National Research Medical Center of the Russian Academy of Sciences

location_facility: Investigaciones Clinico Moleculares (ICM)

location_facility: Texas Oncology-Baylor Charles A. Sammons Cancer Center

location_facility: Dokkyo Medical University Saitama Medical Center

location_facility: FSBI A.V. Vishnevsky National Medical Research Center of Surgery of the MoH RF

location_facility: Kitasato University Kitasato Institute Hospital

intervention_type: Other

lead_sponsor_type: industriel

status_simplified: Ongoing


type: EudraCT Number

title: A Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal, Parallel Group Study of Patiromer for the Management of Hyperkalemia in Subjects Receiving Renin Angiotensin Aldosterone System Inhibitor (RAASi) Medications for the Treatment of Heart Failure (DIAMOND)

acronym: DIAMOND

summary: The purpose of this study is to assess the effects of patiromer compared with placebo on serum K+ in HF patients.

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Prevention

enrollment_type: Actual

ReferenceType: derived

ReferenceCitation: Bolaños JA, Seliger SL. Recurrent Hyperkalemia in Renin-Angiotensin-Aldosterone System Inhibitor (RAASi) Treatment: Stuck between a Rock and a Hard Place. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):345-347. doi: 10.2215/CJN.00950121. Epub 2021 Feb 19.

family: Bolaños

full_name: Jonathan A. Bolaños

given: Jonathan A.

sequence: first

family: Seliger

full_name: Stephen L. Seliger

given: Stephen L.

sequence: additional

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Clinical Journal of the American Society of Nephrology

publisher: American Society of Nephrology (ASN)

publisher_dissemination: American Society of Nephrology

publisher_group: American Society of Nephrology

publisher_normalized: American Society of Nephrology

ipd_sharing: Yes

ipd_sharing_description: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

lead_sponsor: Vifor Pharma, Inc.

location_country:
Belgium
Russian Federation
Ukraine
France
Poland
Argentina
Canada
Netherlands
Bulgaria
Hungary
Germany
United States
United Kingdom
Italy
Brazil
Serbia
Mexico
Czechia
Israel
Georgia
Spain

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intervention_type: Drug

status_simplified: Completed


title: Multi-center Cross-sectional Epidemiological Study to Characterize the Prevalence and Distribution of Lipoprotein(a) Levels Among Patients With Established Cardiovascular Disease

summary: The study is conducted to improve knowledge about the epidemiology of Lipoprotein(a) in patients with established cardiovascular disease (CVD).

primary_purpose: Diagnostic

ipd_sharing: No

lead_sponsor: Novartis Pharmaceuticals

location_country:
Peru
Guatemala
Malaysia
Greece
Romania
Australia
Belgium
Russian Federation
Denmark
Taiwan
Iceland
India
France
Japan
Poland
Slovakia
Thailand
Norway
Argentina
Canada
Slovenia
Korea, Republic of
Colombia
South Africa
Chile
Sweden
Hong Kong
Netherlands
Philippines
Switzerland
Vietnam
Bulgaria
Hungary
Puerto Rico
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Lebanon
Mexico
Czechia
Israel
Egypt
Spain
Turkey

intervention_type: Diagnostic Test


status: Active, not recruiting

ipd_sharing_description: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

lead_sponsor: Amgen

primary_purpose: Treatment

location_country:
Finland
Greece
Romania
Australia
Belgium
Russian Federation
Denmark
Taiwan
Iceland
Ukraine
France
Poland
Lithuania
Slovakia
Argentina
Canada
Korea, Republic of
Sweden
Netherlands
Bulgaria
Hungary
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Czechia
Spain
Estonia
Latvia

acronym: VESALIUS-CV

location_facility: Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council

location_facility: Centro de investigacion Cardiometabolica

location_facility: Hospital Universitario Virgen de la Arrixaca

location_facility: prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance

location_facility: Diagnostic-Consultative Center Convex EOOD

location_facility: Centro de Estudios Clinicos de Queretaro

location_facility: Kyiv City Clinical Emergency Medical Care Hospital

location_facility: Communal Healthcare Institution Kharkiv City Clinical Hospital No27

location_facility: McGill University Health Centre - Montreal General Hospital

location_facility: NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways

location_facility: Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council

location_facility: Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet

location_facility: Applied Medical Informatics Research Incorporated

location_facility: Benedor sro - Kardiologicka, cevni a interni ambulance

location_facility: Multicare Institute for Research and Innovation

location_facility: Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",

location_facility: State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center

location_facility: MeDiNova West London Quality Research Site

location_facility: Centre Hospitalier Regional Universitaire de Montpellier - Hopital Arnaud de Villeneuve

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Heart Health Institute Research Incorporated

location_facility: SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko

location_facility: Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz

location_facility: Policlinico Universitario Campus Biomedico

location_facility: Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza

location_facility: Northwell Health Lenox Hill Heart and Vascular

location_facility: Bajcsy-Zsilinszky Korhaz es Rendelointezet

location_facility: South Texas Cardiovascular Consultants PLLC

location_facility: Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region

location_facility: Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery

location_facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

location_facility: Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz

location_facility: FSBI Russian Cardiology Research and Production Complex

location_facility: The Catholic University of Korea Seoul St Marys Hospital

location_facility: Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw

location_facility: Instituto de Investigaciones Clinicas de San Nicolas

location_facility: Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot

location_facility: Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: Ciprec - Centro de Investigacion y Prevencion Cardiovascular

location_facility: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

location_facility: Papageorgiou General Hospital of Thessaloniki

location_facility: Medinova North London Dedicated Research Centre

location_facility: Instituto de Investigaciones Clinicas Zarate

location_facility: Hospital Clinico Universitario Virgen de la Victoria

location_facility: Novant Health Heart and Vascular Institute

location_facility: Ordensklinikum Linz Barmherzige Schwestern

location_facility: Hospital Clinic i Provincial de Barcelona

location_facility: SBHI of Vladimirskaya region City Hospital 4 of Vladimir

location_facility: North Shore Diabetes and Endocrine Associates

location_facility: Clinique des Maladies Lipidiques de Quebec Incorporated

location_facility: Northwell Health Physician Partners Cardiology

location_facility: Centro de Especialidades Medicas - Cemedic

location_facility: I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz

location_facility: Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano

location_facility: Hospital Universitari i Politecnic La Fe

location_facility: Fifth Multiprofile Hospital for Active Treatment - Sofia EAD

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

location_facility: Center for Clinical and Basic Research Aalborg

location_facility: University of Colorado Memorial Health System

location_facility: My Endo Diabetes and Endocrinology Center

location_facility: Ciad - Consultorio Integral de Atencion al Diabetico

location_facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg

location_facility: NZOZ Specjalistyczna Przychodnia Lekarska Medikard

location_facility: Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska

location_facility: Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main

location_facility: Highlands Clinical Research Facility, Raigmore Hospital

location_facility: Regional Budget Healthcare Institution Cardiology Dispensary

location_facility: Budget Healthcare Institution of Omsk region Medical-sanitary unit 9

location_facility: University Hospitals Cleveland Medical Center

location_facility: Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy

location_facility: Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci

location_facility: SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department

location_facility: Regional State Budget Health care Institution Altay Regional Cardiology Dispensary

location_facility: Universitaets-Herzzentrum Freiburg - Bad Krozingen

location_facility: Albert Schweitzer Ziekenhuis location Dordwijk

location_facility: Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II

location_facility: Clinical Best Solutions Sp zoo Spolka komandytowa

location_facility: Cinme - Centro de Investigaciones Metabolicas

location_facility: Texas Institute for Kidney and Endocrine Disorders

location_facility: Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi

location_facility: Cardiology Consultants of Philadelphia CCP

location_facility: Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD

location_facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

location_facility: Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec

location_facility: Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD

location_facility: KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow

location_facility: Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

location_facility: Associacao Protectora dos Diabeticos de Portugal

location_facility: Ziekenhuis Netwerk Antwerpen Stuivenberg

location_facility: SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg

location_facility: Centre Hospitalier de Versailles - Hopital Andre Mignot

location_facility: Centro Hospitalar e Universitario de Coimbra EPE

location_facility: Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

location_facility: City Clinical Hospital named after Zhadkevich

location_facility: Cardiovascular Research Center of South Florida

location_facility: Universite Catholique de Louvain Cliniques Universitaires Saint Luc

location_facility: Queen Elizabeth II Health Sciences Centre, Halifax Infirmary

location_facility: Hudson Valley Cardiovascular Physicians PC

location_facility: Instituto de Investigaciones Clinicas Mar del Plata

location_facility: Multiprofile Hospital for Active Treatment - Haskovo AD

location_facility: Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej

location_facility: Pauls Stradins Clinical University Hospital

location_facility: Complexo Hospitalario Universitario A Coruña

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie

location_facility: Icba - Instituto Cardiovascular de Buenos Aires

location_facility: Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

location_facility: Kansas City Veterans Affairs Medical Center

location_facility: Hospital Universitario de Gran Canaria Doctor Negrin

location_facility: Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta

location_facility: Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo

location_facility: Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje

location_facility: Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi

location_facility: Dr Lakatos Ferenc Private Cardiology Practice

location_facility: Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie

location_facility: Dr T G Elliott Incorporated - BC Diabetes

location_facility: University Hospitals of Derby and Burton NHS Foundation Trust

location_facility: Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution

location_facility: FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences

location_facility: State Budgetary Health Institution City Hospital 4 of the City of Sochi

location_facility: Harbor University of California Los Angeles Medical Center

location_facility: Centre Hospitalier de Pau - Hopital Francois Mitterrand

location_facility: Instituto de Cardiologia de Corrientes Juana Francisca Cabral

location_facility: Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

location_facility: State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1

location_facility: Saint Petersburg SBHI City Hospital 38 named after N A Semashko

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: Clinical Best Solutions Sp zoo Spolka komandytowa Gabinet Lekarski

location_facility: Hospital Universitario Virgen de las Nieves

location_facility: Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD

location_facility: Jacksonville Center for Clinical Research

location_facility: Universita degli Studi Gabriele D Annunzio di Chieti e Pescara

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: Nebraska Western Iowa Health Care System

location_facility: Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska

location_facility: Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD

location_facility: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

location_facility: Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD

location_facility: Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa

location_facility: Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi

location_facility: Kardiologisch - Angiologische Praxis - Herzzentrum Bremen

location_facility: Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz

location_facility: Bluewater Clinical Research Group Incorporated

location_facility: Konstantopoulio - Agia Olga Hospital of Nea Ionia

location_facility: Zentrum fuer klinische Studien - Dr Hanusch GmbH

location_facility: Siauliai Republican Hospital, Public Institution

location_facility: Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu

location_facility: LMC Clinical Research Incorporated Thornhill

location_facility: Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo

location_facility: BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya

location_facility: Instituto de Pesquisa Clinica de Campinas

location_facility: MUDr Zbynek Kosek, kardiologicka ambulance sro

location_facility: Presidio Ospedaliero Santa Maria delle Grazie

location_facility: Piedmont Medical Group Research of Rocky Mount

location_facility: North York Diagnostic and Cardiac Centre

location_facility: Medizinisches Versorgungszentrum im Altstadt-Carree Fulda

location_facility: Tomasz Blicharski Lubelskie Centrum Diagnostyczne

location_facility: Hamilton Health Sciences Hamilton General Hospital

location_facility: Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department

location_facility: National Scientific Center "M.D. Strazhesko Institute of Cardiology"

location_facility: Kardio Vaclavik sro, Interni a kardiologicka ambulance

location_facility: Western Centre for Public Health and Family Medicine - Western University

location_facility: Samara Regional Clinical Cardiology Dispensary

location_facility: WMCHealth Heart and Vascular Institute Kingston Division of Cardiology

location_facility: Institut de recherches cliniques de Montreal

location_facility: Futuremeds spolka z ograniczona odpowiedzialnoscia

location_facility: Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1

location_facility: Center for Clinical and Basic Research Tallinn

location_facility: Jahn Ferenc Del-pesti Korhaz es Rendelointezet

location_facility: Narodny ustav srdcovych a cievnych chorob, as

location_facility: Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini

location_facility: Azienda Ospedaliera Citta della Salute e della Scienza di Torino

location_facility: Universitaetsklinikum Allgemeines Krankenhaus Wien

location_facility: Almazov National Medical Research Centre

location_facility: University of Florida and Shands Hospital

location_facility: Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum

location_facility: Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon

location_facility: Kardiologicke centrum MUDr Janky Skrobakove sro

location_facility: Tribe Clinical Research LLC DBA Mountain View Clinical Research

location_facility: American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow

location_facility: Sint Antonius Ziekenhuis, locatie Nieuwegein

location_facility: University of North Carolina at Chapel Hill

location_facility: SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky

location_facility: Saint Petersburg State Budget Healthcare Institution City Polyclinic 109

location_facility: Centre Hospitalier Universitaire de Nice - Hopital Pasteur

location_facility: Seoul National University Bundang Hospital

location_facility: Hospital da Senhora da Oliveira, Guimaraes, EPE

location_facility: Markhot Ferenc Oktatokorhaz es Rendelointezet

location_facility: Clinical Hospital named after S R Mirotvortsev

location_facility: Azienda Ospedaliero Universitaria Integrata di Udine

location_facility: State Budget Institution of Ryazan Region Regional Clinical Hospital

location_facility: Central City Clinical Hospital 1 of the Oktyabrsky District

location_facility: NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna

location_facility: Azienda Ospedaliero Universitaria Mater Domini

location_facility: Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand

location_facility: SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L

location_facility: Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital

location_facility: Instituto Medico DAMIC - Fundacion Rusculleda

location_facility: LaPorte County Institute for Clinical Research

location_facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz

location_facility: Metropolitan Cardiovascular Consultants LLC

location_facility: Oleksandrivska Clinical Hospital of Kyiv

location_facility: Midwest Cardiovascular Research Foundation

location_facility: The University of Iowa College of Public Health

location_facility: Center for Clinical Research Pardubice, sro

location_facility: Hospital Universitario Fundacion Favaloro

location_facility: National Medical Research Center for therapy and preventive medicine

location_facility: Fundaçao Hospitalar Sao Francisco de Assis

location_facility: Private Small Enterprise, Medical Center Pulse

location_facility: Praxispont Belvarosi Maganegeszsegugyi Kozpont

location_facility: State Institution National Scientific Center Acad Strazhesko Institute of Cardiology

location_facility: Onze Lieve Vrouw Ziekenhuis - campus Aalst

location_facility: Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD

location_facility: SMH Cardiology Clinical Trials Incorporated

location_facility: Miedziowe Centrum Zdrowia Spolka Akcyjna

location_facility: Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu

location_facility: Dace Teterovska Doctor Practice in Endocrinology

location_facility: Clinical Mayo de Urgencias Medicas Cruz Blanca SRL

location_facility: Centro de Investigaciones Clinicas del Litoral

location_facility: Centre Hospitalier Universitaire de Nimes

location_facility: Medinova South London Dedicated Research Centre

location_facility: Nemocnice Pardubickeho kraje as, Svitavska nemocnice

location_facility: Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna

location_facility: Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant

location_facility: Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

location_facility: Instituto de Investigaciones Clinicas Bahia Blanca

location_facility: Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council

location_facility: Spitalul Clinic Universitar de Urgenta Elias

location_facility: Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter

location_facility: Division of Cardiovascular Research at Peconic Bay Medical Center

location_facility: Vilnius University Hospital Santaros Clinic Public Institution

location_facility: Deutsches Herzzentrum München des Freistaates Bayern

location_facility: SBHI of Novosibirsk Region City clinical hospital 1

location_facility: Kardiologijos ir reabilitacijos klinika, UAB

location_facility: Spitalul Universitar de Urgenta Bucuresti

location_facility: National Multiprofile Transport Hospital Tzar Boris III

location_facility: University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD

location_facility: Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann

location_facility: Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon

location_facility: KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc

location_facility: Treant Zorggroep, locatie Scheper ziekenhuis Emmen

location_facility: Adelaide Cardiology Practice - Leabrook Clinic

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Central Arkansas Veterans Healthcare System

location_facility: University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

location_facility: Cardiovascular Research Foundation of Southern California

location_facility: KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy

location_facility: Azienda Ospedaliero Universitaria Pisana

location_facility: MeDiNova Warwickshire Quality Research Site

location_facility: Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

location_facility: Indywidualna Specjalistyczna Praktyka Lekarska

location_facility: Curtin University Centre of Clinical Research and Education

location_facility: Hospital Clinico Universitario de Santiago

location_facility: MUDr Ladislava Harrerova, kardiologicka ordinace

location_facility: Centre Hospitalier Universitaire Amiens - Hopital Sud

location_facility: Marek Piepiorka Gabinet Kardiologiczno-Internistyczny

location_facility: IBPClin Instituto Brasil de Pesquisa Clinica

location_facility: Albert Schweitzer Ziekenhuis, Locatie Dordwijk

location_facility: Medinova East London Dedicated Research Centre

location_facility: Center for Clinical Trials of Sacramento Inc

location_facility: Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro

location_facility: Gottsegen Gyorgy Orszagos Kardiologiai Intezet

location_facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

location_facility: Medinova Northamptonshire Dedicated Research Site

location_facility: Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

location_facility: FSBI Heart and Vessels Diseases complex problems Scientific Research Institution

location_facility: Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ

location_facility: Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet

location_facility: Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel

location_facility: Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care

location_facility: Centre for Clinical and Basic Research Ballerup

location_facility: First City Clinical Hospital na E E Volosevich

location_facility: Cardresearch Cardiologia Assistencial de Pesquisa

location_facility: Northern Light Eastern Maine Medical Center

location_facility: State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr

location_facility: CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne

location_facility: Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone

location_facility: University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD

location_facility: Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre

location_facility: Westside Medical Associates of Los Angeles

location_facility: Hospital Clinico Universitario de Valladolid

location_facility: Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University

location_facility: Clinical Research Center Spzoo Medic-R Spolka Komandytowa

location_facility: General Hospital of Athens Georgios Gennimatas

location_facility: Centre Hospitalier Universitair Ambroise Pare

location_facility: Center for Clinical and Basic Research Vejle

location_facility: Instituto de Investigaciones Metabolicas - Idim

location_facility: Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III

location_facility: Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas

location_facility: FSBSI Scientific Research Institute of Therapy and preventive medicine

source: euctr

title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

summary: This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.


title: Biomarker Study to Determine Frequency of DNA-repair Defects in Men With Metastatic Prostate Cancer

summary: The purpose of this study is to evaluate the prevalence of 4 or more DNA-repair gene defects in a population of men with metastatic Prostate Cancer (PC) and to use the reported DNA-repair gene defects to assess biomarker eligibility for niraparib interventional studies.

location_country:
Malaysia
Belgium
Australia
Russian Federation
Denmark
Taiwan
Ukraine
France
Poland
Thailand
Argentina
Canada
Korea, Republic of
Sweden
Netherlands
Bulgaria
Germany
United States
United Kingdom
Italy
Brazil
Israel
Belarus
Spain
Turkey

location_facility: Instituto COI de Pesquisa, Educacao e Gestao

location_facility: Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval

location_facility: Adult Pediatric Urology & Urogynecology, P.C

location_facility: Centro de Tratamento de câncer Medradius

location_facility: Fundação Antônio Prudente - A.C. Camargo Cancer Center

location_facility: Russian Scientific Center of Roentgenoradiology

location_facility: Southern Alberta Institute of Urology / Prostate Cancer Centre

location_facility: Hôpitaux Universitaire de Strasbourg -CHU

location_facility: Texas Oncology-Beaumont, Mamie McFaddin Ward Cancer Center

location_facility: State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre

location_facility: Azienda ULSS 3 Serenissima, presidio di Mirano

location_facility: uro Eimsbüttel - Gemeinschaftspraxis Bath/Weinzierl

location_facility: Communal Institution of Ternopil Regional Council 'Ternopil Regional Oncology Center'

location_facility: ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO OCTAVIO FRIAS de OLIVEIRA

location_facility: Przychodnia Lekarska KOMED Roman Karaszewski

location_facility: Instituto Joinvilense De Hematologia e Oncologia

location_facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

location_facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd

location_facility: State Institution N.N. Alexandrov Republican Scientific and

location_facility: Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal

location_facility: Willamette Valley Cancer Institute and Research Center

location_facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

location_facility: Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council

location_facility: Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council

location_facility: IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: University of Washington School of Medicine

location_facility: Azienda Ulss 6 Euganea- Ospedale Di Camposampiero

location_facility: Hospital Beneficência Portuguesa de São Paulo

location_facility: Centre hospitalier universitaire de Québec (CHUQ), L'Hotel-Dieu de Quebéc

location_facility: Centro de Pesquisa do Instituto do Cancer Arnaldo Vieira de Carvalho

location_facility: Bobruisk Interregional Oncological Dispensary

location_facility: Institut de Cancérologie de l'Ouest (ICO)

location_facility: Urologica Praktyka Lekarska Adam Marcheluk

location_facility: Instituto de Investigaciones Clinicas Mar del Plata

location_facility: District Oncology Dispensary with In-Patient Stationary - Plovdiv

location_facility: Specjalistyczna przychodnia lekarska POLIMED

location_facility: Cancer Centre of Southeastern Ontario (Kingston Regional Cancer Centre)

location_facility: Gomel Regional Clinical Oncology Dispensary

location_facility: Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital

location_facility: Dr.Abdurrahman Yurtaslan Oncology Training and Research Hospital

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital

location_facility: Sakarya University Training and Research Hospital

location_facility: Centers for Advanced Urology, LLC; d/b/a MidLantic Urology

location_facility: Communal Nonprofit Enterprise 'Regional Clinical Oncology Center of Kirovohrad Regional Council'

location_facility: Bursa Yuksek lhtisas EAH Medikal Onkoloji Klinigi

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: Urologie im Schlosscarree Schreier/Eichler/Junius - Germany

location_facility: Miami Cancer Institute at Baptist Health / Baptist Health Medical Group

location_facility: PP.OO. di Piombino e Portoferraio Azienda USL Toscana nord ovest

location_facility: University Health Network (UHN) Princess Margaret Cancer Centre

location_facility: CINME - Centro de Investigaciones Metabolicas

location_facility: Eastern Connecticut Hematology & Oncology Assoc.

location_facility: Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.

location_facility: Fort Wayne Medical Oncology and Hematology, Inc.

location_facility: T.C. Saglik Bakanlıgi Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi

location_facility: Klinikum Region Hannover Klinikum Siloah

location_facility: Urological Associates of Southern Arizona, P.C.

location_facility: University of Pittsburgh Medical Center (UPMC)

location_facility: Consultants in Medical Oncology and Hematology, P.C. - Abington

location_facility: Texas Oncology Deke Slayton Cancer Center

location_facility: Centre de radiothérapie et d'Oncologie médicale de l'Essonne

location_facility: Ce 'Dnipropetrovsk Regional Clinical Hospital N.A. Mechnikov' of Dnipropetrovsk Rc

location_facility: Hospital Do Cancer De Barretos - Fundacao Pio Xii

location_facility: Frederick Health Hospital - James M Stockman Cancer Institute

location_facility: Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center

location_facility: Russian Scientific Center of Radiology and Surgical Technologies

location_facility: Centre Hospitalier Regional Universitaire Besancon

location_facility: Seoul National University Bundang Hospital

location_facility: Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council

location_facility: Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás

location_facility: Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO

location_facility: Multifunctional clinical medical center 'Medical city'

location_facility: Municipal non-profit enterprise 'Regional Center of Oncology'

location_facility: Kyungpook National University Chilgok Hospital

location_facility: Centrum Onkologii im. Prof. F. Lukaszczyka

location_facility: Istanbul University Istanbul Medical Faculty

location_facility: Urologische Gemeinschaftspraxis Böhm/Linne - Germany

location_facility: CIONC - Centro Integrado de Oncologia de Curitiba

location_facility: Virginia Commonwealth University - Massey Cancer Center

location_facility: Azienda ULSS5 Polesana di Rovigo - Ospedale Santa Maria della Misericordia

location_facility: British Columbia Cancer Agency (BCCA) - Vancouver Centre

location_facility: Beth Israel Deaconess Hospital Plymouth, Jordan Club Cancer Center

location_facility: Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council'

location_facility: Cemaic - Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica

location_facility: Instituto de Ensino E Pesquisa Sao Lucas

location_facility: Private Medical Institution Euromedservice

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine

location_facility: Minsk city Clinical Oncological Dispensary

location_facility: Centre Hopitalier Inter-Communal De Cornouaille

location_facility: ME 'Poltava Regional Clinical Hospital n.a. M.V. Sklifosovsky of the Poltava Regional Council'

location_facility: CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia

location_facility: State Institution National Cancer Institute

location_facility: University of Wisconsin Carbone Cancer Center

location_facility: Oklahoma Cancer Specialists and Research Institute, LLC

location_facility: Hospital Privado - Centro Medico de Cordoba

location_facility: British Columbia Cancer Agency - Vancouver Island Centre

location_facility: PERSONAL - Oncologia de Precisão e Personalizada

location_facility: MemorialCare Research Miller Children's and Women's Hospital Long Beach

location_facility: Texas Oncology-Midland Allison Cancer Center


lead_sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland

location_country: Luxembourg Austria Sweden Switzerland Netherlands Finland France Lithuania Norway Ireland Australia Belgium Spain Estonia Germany

location_facility:
ES-Palma-SSIB
AU-Adelaide-FLINDERS
FR-Marseille-IPC
FR-Toulouse-CHUTOULOUSE
NL-Breda-AMPHIA
NL-Amsterdam-OLVG
AU-Sydney-SVHS
NL-Leeuwarden-MCL
ES-Barcelona-GERMANTRIALS
IE-Cork-CUH
DE-Dortmund-JOHODORTMUND
DE-Magdeburg-OVGU
CH-Luzern-LUKS
FR-Paris cedex 10-SAINTLOUIS
BE-Yvoir-MONTGODINNE
FR-Angers-CHUANGERS
DE-Berlin-CAMPUSBENFRANKLIN
DE-Düsseldorf-MEDUNIDUESSELDORF
DE-Mainz-UNIMEDIZINMAINZ
DE-Passau-KLINIKUMPASSAU
BE-Haine-Saint-Paul-JOLIMONT
FR-Rennes cedex 9-CHURENNES
FR-Vandoeuvre Les Nancy-CHRUNANCY
DE-Ulm-UNIKLINKULM
AT-Innsbruck-IMED
FR-Nice-LARCHET
FR-Rouen cedex-BECQUEREL
DE-Hanau-KLINIKUMHANAU
EE-Tartu-TARTU
NL-Nijmegen-RADBOUDUMC
DE-Wuppertal-HELIOSGESUNDHEIT
CH-Bellinzona-IOSI
NL-Den Bosch-JBZ
DE-Bremen-KBM
NL-Utrecht-UMCUTRECHT
DE-Oldenburg-KLINIKUMOLDENBURG
FR-Paris cedex 15-NECKER
FR-Limoges-CHULIMOGES
FR-Nice-CAL
DE-Hamburg-UKE
AU-Melbourne-MONASH
BE-Leuven-UZLEUVEN
NO-Stavanger-HELSESTAVANGER
FR-Orléans-CHORLEANS
FR-Clermont-Ferrand-ESTAING
FR-Lille-CHULILLE
AU-Melbourne-RMELBOURNE
NL-Rotterdam-ErasmusMC
DE-Giessen-UKGM
BE-Liege-CHRCITADELLE
AT-Linz-ORDENSKLINIKUM
DE-Villingen-Schwenningen-SBKVS
NL-Groningen-UMCG
FR-Chambery-CHMETROPOLESAVOIE
DE-München-IRZTUM
SE-Lund-SUH
FR-Grenoble cedex 9-CHUGRENOBLE
NO-Trondheim-STOLAV
FI-Helsinki-HUS
DE-Braunschweig-KLINIKUMBRAUNSCHWEIG
CH-St. Gallen-KSSG
FR-Nantes-CHUNANTES
DE-Tübingen-MEDUNITUEBINGEN
DE-Stuttgart-KLINIKUMSTUTTGART
IE-Dublin 8-STJAMES
ES-Girona-ICSTRUETA
AU-Waratah-CALVARYMATER
FR-Clamart-HIAPERCY
NL-Dordrecht-ASZ
NL-Delft-RDGG
CH-Zürich-USZ
NO-Tromsø-NORTHNOORWEGEN
BE-Liege-CHULIEGE
NL-Nieuwegein-ANTONIUS
FR-Lens-CHLENS
FI-Tampere-TAYS
NL-Amsterdam-VUMC
DE-Traunstein-TSSOB
FR-Le Chesnay cedex-CHVERSAILLES
FR-Pessac Cedex-CHUBORDEAUX
ES-Barcelona-MUTUATERRASSA
AU-Sydney-WSAH
FR-Bayonne-CHCOTEBASQUE
ES-Barcelona-PARCDESALUTMAR
DE-Karlsruhe-KLINIKUMKARLSRUHE
FR-Strasbourg cedex-HAUTEPIERRE
DE-Luedenscheid-KLINIKUMLUEDENSCHEID
DE-Mainz-KLINKUNIMAINZ
AU-Douglas-TOWNSVILLE
DE-Hannover-MHHANNOVER
BE-Brussel-BORDET
NL-Zwolle-ISALA
FR-Poitiers-CHUPOITERS
DE-Flensburg-MALTESER
ES-Madrid-CSGREGORIOMARANON
DE-Meschede-HOCHSAUERLAND
FR-Créteil cedex-CHUMONDOR
FR-Besançon Cedex-JEANMINJOZ
FR-Villejuif-GUSTAVEROUSSY
DE-Lebach-CARITASKHLEBACH
FR-Reims-CHREIMS
SE-Uppsala-UPPSALAUH
FR-Mulhouse-GHRMSA
DE-Hamburg-ASKLEPIOS
BE-Antwerpen-ZNASTUIVENBERG
NL-Arnhem-RIJNSTATE
DE-Stuttgart-DIAKSTUTTGART
AU-Sydney-RNSH
DE-Berlin-CAMPUSVIRCHOW
DE-Ludwigshafen-KLILU
DE-Homburg-UNIKLINIKSAARLAND
NO-Bergen-HELSEBERGEN
DE-Bonn-UNIBONN
DE-Offenburg-ORTENAUKLINIKUM
AU-Camperdown-RPA
AU-Adelaide-RAH
NO-Oslo-OSLOUH
CH-Basel-USB
AU-Perth-RPH
BE-Gent-UZGENT
DE-Minden-MUEHLENKREISKLINKEN
DE-Bad Saarow-HELIOSBADSAAROW
DE-Berlin-VIVANTESNEUKOLLN
AU-Launceston TAS-LAUNCESTON
ES-Valencia-MALVARROSA
NL-Leiden-LUMC
FR-Tours cedex-BRETONNEAU
DE-Trier-MUTTERHAUS
DE-Essen-KEM
ES-Tarragona-JOAN
DE-Goch-KKLE
IE-Dublin 9-BEAUMONT
IE-Galway-UHGALWAY
FR-Bobigny-AVICENNE
NL-Den Haag-HAGA
FR-Amiens-CHUAMIENS
FR-Paris cedex 12-SAINTANTOINE
BE-Roeselare-AZDELTA
DE-Hamm-EVKHAMM
AU-Melbourne-AUSTIN
ES-Barcelona-SANTPAU
DE-Herne-MARIENHOSPITALHERNE
BE-Bruxelles-STLUC
AU-Hobart TAS-RHOBART
AU-Perth-SCGH
FR-Montpellier-STELOI
LT-Vilnius-SANTA
CH-Bern-INSEL
DE-Bochum-RUB
AU-Sydney-CONCORD
LU-Luxembourg-CHL
BE-Brussel-UZBRUSSEL
DE-Esslingen-KLINIKUMESSLINGEN
NL-Eindhoven-MAXIMAMC
AT-Vienna-HANUSCH
ES-Barcelona-VHEBRON
CH-Fribourg-HFR
CH-Lausanne-CHUV
AU-Melbourne-ALFRED
FR-Lyon-LEONBERARD
DE-Lemgo-KLINIKUMLIPPE
DE-München-MEDUNIMUNCHIN
ES-Barcelona-CLINICUB
AU-Brisbane-PAH
NL-Enschede-MST
ES-Barcelona-ICODURANREYNALS
AU-Perth-FSH
SE-Stockholm-KAROLINSKAHUDDINGE
DE-Hannover-SILOAHKRH
FR-Argenteuil-CHARGENTEUIL
AU-Melbourne-SVHM
AT-Graz-MEDUNIGRAZ
DE-Berlin-VIVANTESURBAN
FR-Lyon Pierre Benite cedex-LYONSUD
CH-Geneve (14)-HCUGE
BE-Brugge-AZBRUGGE
NL-Maastricht-MUMC
DE-Hamburg-ASKLEPIOSSTGEORG
BE-Hasselt-VIRGAJESSE
NL-Amersfoort-MEANDERMC
AU-Canberra-CANBERRAHOSPITAL
NL-Amsterdam-AMC

title: A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome With Excess Blasts-2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy.

summary: AML and MDS-EB2 are malignancies of the bone marrow. The standard treatment for these diseases is chemotherapy. Patients participating have a special type of this disease because the leukemia cells (blasts) have developed an error in the genetic material (DNA). This error is called an IDH1 mutation or an IDH2 mutation (a mutation is a change in the DNA), which leads to changes in specific substances in the leukemia cells. This trial will investigate whether the addition of the new drugs Ivosidenib (for patients with IDH1 mutation) or Enasidenib (for patients with IDH2 mutation) to the standard treatment of chemotherapy controle the disease more effectively and for a longer period.


type: Registry Identifier

title: A Phase 3, Randomized Open-label Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Who Are Unselected for Homologous Recombination Repair Defects and Have Failed Prior Treatment With One Next-generation Hormonal Agent (NHA) and Chemotherapy (KEYLYNK-010)

summary:
The purpose of this study is to assess the efficacy and safety of the combination of the polyadenosine 5'-diphosphoribose poly(ADP-ribose) polymerase (PARP) inhibitor olaparib and pembrolizumab in the treatment of participants with mCRPC who have failed to respond to either abiraterone acetate or enzalutamide (but not both) and to chemotherapy.

The primary study hypotheses are that the combination of pembrolizumab plus olaparib is superior to abiraterone acetate or enzalutamide with respect to:

Overall Survival (OS) and
Radiographic progression-free survival (rPFS) per Prostate Cancer Working Group (PCWG)-modified Response Evaluation Criteria in Solid Tumors Version 1.1 as assessed by blinded independent central review (BICR)

lead_sponsor: Merck Sharp & Dohme Corp.

location_country:
Italy
Austria
Brazil
Chile
Netherlands
Spain
Germany
France
Japan
Korea, Republic of
Israel
Ireland
Argentina
Australia
New Zealand
Russian Federation
United States
United Kingdom
Canada
Taiwan

location_facility: Antoni van Leeuwenhoek Ziekenhuis ( Site 0480)

location_facility: IBCC - Instituto Brasileiro de Controle do Câncer ( Site 1040)

location_facility: The Urology Group- Cincinnati ( Site 0094)

location_facility: Fundacion Arturo Lopez Perez ( Site 1049)

location_facility: University of Miyazaki Hospital ( Site 0721)

location_facility: Yamaguchi University Hospital ( Site 0717)

location_facility: Institut De Cancerologie De L Ouest ( Site 0448)

location_facility: St. Vincent Frontier Cancer Center ( Site 0016)

location_facility: Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035)

location_facility: Severance Hospital Yonsei University Health System ( Site 0173)

location_facility: Gabrail Cancer Center-Research ( Site 0097)

location_facility: CHU de Brest -Site Hopital Morvan ( Site 0441)

location_facility: Institut Claudius Regaud IUCT Oncopole ( Site 0418)

location_facility: Peter MacCallum Cancer Centre ( Site 0152)

location_facility: Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0301)

location_facility: Hospital de Caridade de Ijui ( Site 1038)

location_facility: University Hospitals Bristol NHS Foundation Trust ( Site 0530)

location_facility: Cambridge University Hospitals NHS Trust ( Site 0540)

location_facility: Instituto Medico Alexander Fleming ( Site 1010)

location_facility: Toho University Sakura Medical Center ( Site 0703)

location_facility: Policlinico S.Orsola-Malpighi ( Site 0453)

location_facility: Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565)

location_facility: Medical Oncology Ospedale San Donato ( Site 0461)

location_facility: Hamamatsu University Hospital ( Site 0720)

location_facility: Instituto Catalan de Oncologia - ICO ( Site 0330)

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0462)

location_facility: UMass Memorial Medical Center ( Site 0053)

location_facility: Southern Medical Day Care Centre ( Site 0160)

location_facility: Institut Mutualiste Montsouris ( Site 0446)

location_facility: Dana Farber Cancer Institute ( Site 0033)

location_facility: Beth Israel Deaconess Medical Ctr. ( Site 0093)

location_facility: Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021)

location_facility: Hospital Universitario Virgen de la Victoria ( Site 0337)

location_facility: St. Joseph Heritage Healthcare ( Site 0069)

location_facility: Fujita Health University Hospital ( Site 0724)

location_facility: Clinical Research Center of specialized types medical care-Oncology ( Site 0570)

location_facility: Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304)

location_facility: Omsk Clinical Oncology Dispensary ( Site 0568)

location_facility: Medizinische Universitaet Wien ( Site 0375)

location_facility: University of New Mexico Cancer Center ( Site 0048)

location_facility: Princess Margaret Cancer Centre ( Site 0107)

location_facility: National Hospital Organization Shikoku Cancer Center ( Site 0716)

location_facility: Nippon Medical School Hospital ( Site 0709)

location_facility: Instituto de Investigaciones Metabolicas ( Site 1011)

location_facility: SBHI Leningrad Regional Oncology Dispensary ( Site 0588)

location_facility: Medizinische Universitat Graz ( Site 0374)

location_facility: Nagasaki University Hospital ( Site 0719)

location_facility: Chonnam National University Hwasun Hospital ( Site 0174)

location_facility: Istituto Clinico Humanitas Research Hospital ( Site 0452)

location_facility: Universitaetsklinikum Duesseldorf ( Site 0306)

location_facility: Institut Regional du Cancer de Montpellier - ICM ( Site 0443)

location_facility: Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318)

location_facility: Nara Medical University Hospital ( Site 0715)

location_facility: Pontificia Universidad Catolica de Chile ( Site 1047)

location_facility: Kitasato University Hospital ( Site 0705)

location_facility: Presidio Ospedaliero Santa Chiara ( Site 0451)

location_facility: Azienda Ospedaliera San Camillo Forlanini ( Site 0455)

location_facility: Hospital de Base de Sao Jose de Rio Preto ( Site 1022)

location_facility: Franciscus Gasthuis en Vlietland ( Site 0489)

location_facility: Hospital San Pedro de Alcantara ( Site 0326)

location_facility: UCLA Hematology/Oncology - Santa Monica ( Site 0081)

location_facility: Russian Scientific Center of Roentgenoradiology ( Site 0559)

location_facility: Taipei Veterans General Hospital ( Site 0135)

location_facility: BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 0113)

location_facility: Nebraska Cancer Specialists ( Site 0034)

location_facility: National Cancer Center Hospital East ( Site 0702)

location_facility: National Cheng Kung University Hospital ( Site 0134)

location_facility: Ordensklinikum Linz GmbH Elisabethinen ( Site 0373)

location_facility: CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102)

location_facility: Barbara Ann Karmanos Cancer Institute ( Site 0077)

location_facility: John Flynn Hospital & Medical Centre ( Site 0164)

location_facility: Hospital Britanico de Buenos Aires ( Site 1006)

location_facility: Centro de Diagnostico Urologico ( Site 1008)

location_facility: Azienda Ospedaliera Cannizzaro ( Site 0458)

location_facility: Yokohama City University Medical Center ( Site 0706)

location_facility: Bradford Hill Centro de Investigaciones Clinicas ( Site 1044)

location_facility: Royal Brisbane and Women s Hospital ( Site 0155)

location_facility: Universitaetsklinikum in Mannheim ( Site 0314)

location_facility: Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116)

location_facility: National Taiwan University Hospital ( Site 0131)

location_facility: Radboud University Medical Center ( Site 0470)

location_facility: China Medical University Hospital ( Site 0132)

location_facility: Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567)

location_facility: Universitaetsklinikum Erlangen ( Site 0303)

location_facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0005)

location_facility: Seattle Cancer Care Alliance ( Site 0079)

location_facility: CHU Amiens Picardie Site Sud Amiens ( Site 0438)

location_facility: Universitaetsklinik fuer Urologie ( Site 0307)

location_facility: Kanazawa University Hospital ( Site 0701)

location_facility: Tallaght University Hospital ( Site 0730)

location_facility: Saitama Medical University International Medical Center ( Site 0708)

location_facility: Associated Medical Professionals of NY ( Site 0060)

location_facility: Hadassah Ein Kerem Medical Center ( Site 0546)

location_facility: Osaka International Cancer Institute ( Site 0722)

location_facility: Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013)

location_facility: Hospital General Universitari Vall d Hebron ( Site 0334)

location_facility: Fondazione Policlinico Universitario A. Gemelli ( Site 0463)

location_facility: CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0103)

location_facility: Georgia Cancer Center at Augusta University ( Site 0026)

location_facility: Taichung Veterans General Hospital ( Site 0133)

location_facility: Kobe City Medical Center General Hospital ( Site 0726)

location_facility: Centre D Oncologie de Gentilly ( Site 0432)

location_facility: University Hospitals of Cleveland Seidman Cancer Center ( Site 0036)

location_facility: Vrije Universiteit Medisch Centrum ( Site 0479)

location_facility: Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585)

location_facility: Central Clinical Hospital with Polyclinic ( Site 0562)

location_facility: Tomsk National Scientific Medical Center of Russian Academy of Science ( Site 0579)

location_facility: Port Macquarie Base Hospital ( Site 0153)

location_facility: Froedtert and Medical College of Wisconsin ( Site 0045)

location_facility: William Osler Health System (Brampton Civic Hospital) ( Site 0121)

location_facility: Comprehensive Cancer Centers of Nevada ( Site 0092)

location_facility: SBHI Samara Regional Clinical Oncology Dispensary ( Site 0576)

location_facility: Krankenhaus der Barmherzigen Brueder Trier ( Site 0310)

location_facility: CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0105)

location_facility: Nova Scotia Health Authority QEII-HSC ( Site 0114)

location_facility: Dokkyo Medical University Saitama Medical Center ( Site 0707)

location_facility: Chesapeake Urology Research Associates ( Site 0076)

location_facility: Centro Investigación del Cáncer James Lind ( Site 1041)

location_facility: University of North Midlands NHS Foundation Trust ( Site 0527)

location_facility: Carolina Urologic Research Center ( Site 0070)

location_facility: Azienda Ospedaliera Santa Maria Terni ( Site 0456)

location_facility: Centre Hospitalier Regional du Orleans ( Site 0430)

location_facility: Haaglanden MC - locatie Antoniushove ( Site 0471)


title: A Phase 3, Randomized, Double-blind Study of Pembrolizumab (MK-3475) Plus Docetaxel Plus Prednisone Versus Placebo Plus Docetaxel Plus Prednisone in Participants With Chemotherapy-naïve Metastatic Castration-Resistant Prostate Cancer (mCRPC) Who Have Progressed on a Next Generation Hormonal Agent (NHA) (KEYNOTE-921)

summary:
The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and docetaxel in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC but have progressed on or are intolerant to Next Generation Hormonal Agent (NHA).

There are two primary study hypotheses.

Hypothesis 1: The combination of pembrolizumab plus docetaxel plus prednisone is superior to placebo plus docetaxel plus prednisone with respect to Overall Survival (OS).

Hypothesis 2: The combination of pembrolizumab plus docetaxel plus prednisone is superior to placebo plus docetaxel plus prednisone with respect to Radiographic Progression-free Survival (rPFS) per Prostate Cancer Working Group (PCWG)-modified Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review.

ReferenceCitation: Petrylak DP, Ratta R, Gafanov R, Facchini G, Piulats JM, Kramer G, Flaig TW, Chandana SR, Li B, Burgents J, Fizazi K. KEYNOTE-921: Phase III study of pembrolizumab plus docetaxel for metastatic castration-resistant prostate cancer. Future Oncol. 2021 Sep;17(25):3291-3299. doi: 10.2217/fon-2020-1133. Epub 2021 Jun 8.

name: Department of Internal Medicine, Smilow Cancer Hospital, Yale School of Medicine, New Haven, CT 06511, USA

family: Petrylak

full_name: Daniel P Petrylak

given: Daniel P

name: Department of Medical Oncology, Foch Hospital, Suresnes, 92151, France

family: Ratta

full_name: Raffaele Ratta

given: Raffaele

name: Department of Oncourology, Russian Scientific Center of Roentgen Radiology, Moscow, 117997, Russia

family: Gafanov

full_name: Rustem Gafanov

given: Rustem

name: Departmental Unit of Experimental Uro-Androlo, Istituto Nazionale Tumori IRCCS, Fondazione G. Pascale, Naples, 80131, Italy

family: Facchini

full_name: Gaetano Facchini

given: Gaetano

name: Department of Medical Oncology, Catalan Institute of Oncology, Barcelona, 08908, Spain

family: Piulats

full_name: Josep M Piulats

given: Josep M

name: Department of Urology, Medical University of Vienna, Vienna, 1090, Austria

family: Kramer

full_name: Gero Kramer

given: Gero

name: Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA

family: Flaig

full_name: Thomas W Flaig

given: Thomas W

name: Department of Medical Oncology, Cancer & Hematology Centers of Western Michigan, Grand Rapids, MI 49503, USA

family: Chandana

full_name: Sreenivasa R Chandana

given: Sreenivasa R

name: Department of Clinical Research, Merck & Co., Inc., Kenilworth, NJ 07033, USA

family: Li

full_name: Ben Li

given: Ben

family: Burgents

full_name: Joseph Burgents

given: Joseph

name: Department of Cancer Medicine, Institut Gustave Roussy and University of Paris Saclay, Villejuif, 94800, France

family: Fizazi

full_name: Karim Fizazi

given: Karim

journal_name: Future Oncology

oa_host_type: publisher

evidence: open (via page says license)

host_type: publisher

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

version: publishedVersion

publisher: Future Medicine Ltd

publisher_dissemination: Future Science Ltd

publisher_group: Future Science Ltd

publisher_normalized: Future Science Ltd

location_country:
Australia
Russian Federation
Taiwan
France
Japan
Argentina
Canada
Korea, Republic of
Colombia
Chile
Netherlands
Ireland
China
Germany
United States
United Kingdom
Italy
Austria
Brazil
Israel
Spain

location_facility: Antoni van Leeuwenhoek Ziekenhuis ( Site 0480)

location_facility: SPb SBHI City Clinical Oncological Dispensary ( Site 0571)

location_facility: Sun Yat Sen Memorial Hospital ( Site 1323)

location_facility: Hospital Universitario HM Sanchinarro ( Site 0322)

location_facility: Fundacion Arturo Lopez Perez ( Site 1049)

location_facility: University of Miyazaki Hospital ( Site 0721)

location_facility: Zhongshan Hospital Fudan University ( Site 1301)

location_facility: The Second Affiliated Hospital of Zhejiang University School of Medicine ( Site 1309)

location_facility: A.O. Universitaria di Modena ( Site 0454)

location_facility: Yamaguchi University Hospital ( Site 0717)

location_facility: Centro de Investigaciones Clinicas Vina del Mar ( Site 1042)

location_facility: Institut De Cancerologie De L Ouest ( Site 0448)

location_facility: St. Vincent Frontier Cancer Center ( Site 0016)

location_facility: Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035)

location_facility: National Medical Research Radiological Center ( Site 0556)

location_facility: CHU de Brest -Site Hopital Morvan ( Site 0441)

location_facility: Institut Claudius Regaud IUCT Oncopole ( Site 0418)

location_facility: Instituto Nacional de Cancerologia E.S.E ( Site 1061)

location_facility: SBIH City clinical hospital named after D.D. Pletniov ( Site 0575)

location_facility: Seoul National University Hospital ( Site 0171)

location_facility: Hospital de Caridade de Ijui ( Site 1038)

location_facility: University Hospitals Bristol NHS Foundation Trust ( Site 0530)

location_facility: Cambridge University Hospitals NHS Trust ( Site 0540)

location_facility: Instituto Medico Alexander Fleming ( Site 1010)

location_facility: Toho University Sakura Medical Center ( Site 0703)

location_facility: Seoul National University Bundang Hospital ( Site 0175)

location_facility: Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565)

location_facility: Hospital Clinico San Carlos ( Site 0324)

location_facility: Harbin Medical University Cancer Hospital ( Site 1326)

location_facility: Leningrad Regional Oncology Center ( Site 0588)

location_facility: Hamamatsu University Hospital ( Site 0720)

location_facility: Universitaetsklinikum des Saarlandes ( Site 0348)

location_facility: Peking University First Hospital ( Site 1303)

location_facility: Instituto Catalan de Oncologia - ICO ( Site 0330)

location_facility: Universitaetsklinikum Goettingen ( Site 0345)

location_facility: Institut Mutualiste Montsouris ( Site 0446)

location_facility: University Hospitals Cleveland Medical Center ( Site 0036)

location_facility: Instituto de Investigaciones Metabolicas [Buenos Aires, Argentina] ( Site 1011)

location_facility: Centro Medico Imbanaco de Cali S.A ( Site 1064)

location_facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0457)

location_facility: Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021)

location_facility: Zhejiang Provincial People's Hospital ( Site 1310)

location_facility: Oncologos del Occidente S.A. ( Site 1072)

location_facility: The First Affiliated Hospital of Xiamen University ( Site 1319)

location_facility: Tomsk National Research Medical Center of Russian Academy of Sciences ( Site 0579)

location_facility: Universitaetsklinikum Wuerzburg ( Site 0302)

location_facility: Inova Schar Cancer Institute ( Site 0006)

location_facility: Nanjing Drum Tower Hospital ( Site 1312)

location_facility: Hospital Universitario Virgen de la Victoria ( Site 0337)

location_facility: Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1062)

location_facility: St. Joseph Heritage Healthcare ( Site 0069)

location_facility: Clinical Research Center of specialized types medical care-Oncology ( Site 0570)

location_facility: Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304)

location_facility: Cancer & Hematology Centers of Western Michigan ( Site 0013)

location_facility: W. G. Bill Hefner VA Medical Center ( Site 0029)

location_facility: University of California San Francisco ( Site 0023)

location_facility: The Fifth Medical Center of PLA General Hospital ( Site 1307)

location_facility: Medizinische Universitaet Wien ( Site 0375)

location_facility: Omsk Clinical Oncology Dispensary ( Site 0568)

location_facility: Princess Margaret Cancer Centre ( Site 0107)

location_facility: National Hospital Organization Shikoku Cancer Center ( Site 0716)

location_facility: Nippon Medical School Hospital ( Site 0709)

location_facility: University of Southern California Norris Comprehensive Cancer Center ( Site 0061)

location_facility: Medizinische Universitat Graz ( Site 0374)

location_facility: Nagasaki University Hospital ( Site 0719)

location_facility: Istituto Clinico Humanitas Research Hospital ( Site 0452)

location_facility: Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318)

location_facility: Nara Medical University Hospital ( Site 0715)

location_facility: Washington University School of Medicine ( Site 0057)

location_facility: Pontificia Universidad Catolica de Chile ( Site 1047)

location_facility: Kitasato University Hospital ( Site 0705)

location_facility: Presidio Ospedaliero Santa Chiara ( Site 0451)

location_facility: Hospital Universitario Marques de Valdecilla ( Site 0336)

location_facility: Azienda Ospedaliera San Camillo Forlanini ( Site 0455)

location_facility: Hospital de Base de Sao Jose de Rio Preto ( Site 1022)

location_facility: Russian Scientific Center of Radiology ( Site 0559)

location_facility: Methodist Hospital- Merriillville ( Site 0008)

location_facility: USC Norris Oncology Hematology Newport Beach ( Site 0093)

location_facility: Taipei Veterans General Hospital ( Site 0135)

location_facility: Hospital Consorci Sanitari Parc Tauli ( Site 0335)

location_facility: Nebraska Cancer Specialists ( Site 0034)

location_facility: National Cancer Center Hospital East ( Site 0702)

location_facility: National Cheng Kung University Hospital ( Site 0134)

location_facility: Ordensklinikum Linz GmbH Elisabethinen ( Site 0373)

location_facility: CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102)

location_facility: John Flynn Hospital & Medical Centre ( Site 0164)

location_facility: Hospital Britanico de Buenos Aires ( Site 1006)

location_facility: Centro de Diagnostico Urologico ( Site 1008)

location_facility: Azienda Ospedaliera Cannizzaro ( Site 0458)

location_facility: Yokohama City University Medical Center ( Site 0706)

location_facility: Bradford Hill Centro de Investigaciones Clinicas ( Site 1044)

location_facility: Sunnybrook Research Institute ( Site 0108)

location_facility: Mount Sinai Hospital Medical Center ( Site 0042)

location_facility: University of Colorado Cancer Center ( Site 0022)

location_facility: Universitaetsklinikum in Mannheim ( Site 0314)

location_facility: Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116)

location_facility: National Taiwan University Hospital ( Site 0131)

location_facility: CHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0103)

location_facility: Radboud University Medical Center ( Site 0470)

location_facility: The First Affiliated Hospital of Guangzhou Medical University ( Site 1330)

location_facility: China Medical University Hospital ( Site 0132)

location_facility: Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567)

location_facility: Volga District Medical Center Federal Medical and Biological Agency ( Site 0572)

location_facility: University of South Alabama, Mitchell Cancer Institute ( Site 0065)

location_facility: CHU Amiens Picardie Site Sud Amiens ( Site 0438)

location_facility: Universitaetsklinik fuer Urologie ( Site 0307)

location_facility: Kanazawa University Hospital ( Site 0701)

location_facility: Tallaght University Hospital ( Site 0730)

location_facility: Fudan University Shanghai Cancer Center ( Site 1300)

location_facility: Saitama Medical University International Medical Center ( Site 0708)

location_facility: Associated Medical Professionals of NY ( Site 0060)

location_facility: Hadassah Ein Kerem Medical Center ( Site 0546)

location_facility: John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004)

location_facility: Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013)

location_facility: Georgia Cancer Center at Augusta University ( Site 0026)

location_facility: Taichung Veterans General Hospital ( Site 0133)

location_facility: Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1068)

location_facility: Centre D Oncologie de Gentilly ( Site 0432)

location_facility: Oregon Health Sciences University ( Site 0031)

location_facility: Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585)

location_facility: Central Clinical Hospital with Polyclinic ( Site 0562)

location_facility: Charite Universitaetsmedizin Berlin ( Site 0301)

location_facility: Hospital Universitario Ramon y Cajal ( Site 0328)

location_facility: Instituto de Investigaciones Clinicas ( Site 1000)