type: Other Identifier

title: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effect of Alirocumab (SAR236553/REGN727) on the Occurrence of Cardiovascular Events in Patients Who Have Recently Experienced an Acute Coronary Syndrome

summary:
Primary Objective:

To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and non-fatal ischemic stroke, unstable angina (UA) requiring hospitalization) in participants who experienced an acute coronary syndrome (ACS) event 4 to 52 weeks prior to randomization and were treated with evidence-based medical and dietary management of dyslipidemia.

Secondary Objectives:

To evaluate the effect of alirocumab on secondary endpoints (any CHD event , major CHD event, any CV event, composite of all cause mortality/non-fatal MI/non-fatal ischemic stroke, CHD deaths, CV deaths, all cause mortality).
To evaluate the safety and tolerability of alirocumab.
To evaluate the effect of alirocumab on lipid parameters.

primary_purpose: Prevention

ReferenceCitation: Schwartz GG, Szarek M, Bittner VA, Diaz R, Goodman SG, Jukema JW, Landmesser U, López-Jaramillo P, Manvelian G, Pordy R, Scemama M, Sinnaeve PR, White HD, Gabriel Steg P; ODYSSEY Outcomes Committees and Investigators. Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol. J Am Coll Cardiol. 2021 Aug 3;78(5):421-433. doi: 10.1016/j.jacc.2021.04.102.

family: Schwartz

full_name: Gregory G. Schwartz

given: Gregory G.

family: Szarek

full_name: Michael Szarek

given: Michael

family: Bittner

full_name: Vera A. Bittner

given: Vera A.

family: Diaz

full_name: Rafael Diaz

given: Rafael

family: Goodman

full_name: Shaun G. Goodman

given: Shaun G.

family: Jukema

full_name: J. Wouter Jukema

given: J. Wouter

family: Landmesser

full_name: Ulf Landmesser

given: Ulf

family: López-Jaramillo

full_name: Patricio López-Jaramillo

given: Patricio

family: Manvelian

full_name: Garen Manvelian

given: Garen

family: Pordy

full_name: Robert Pordy

given: Robert

family: Scemama

full_name: Michel Scemama

given: Michel

family: Sinnaeve

full_name: Peter R. Sinnaeve

given: Peter R.

family: White

full_name: Harvey D. White

given: Harvey D.

family: Gabriel Steg

full_name: Ph Gabriel Steg

given: Ph

full_name: P.h. Gabriel Steg

family: Bhatt

full_name: Deepak L. Bhatt

given: Deepak L.

family: Harrington

full_name: Robert A. Harrington

given: Robert A.

full_name: Branislav Schifferdecker ;John M Gilbert

journal_name: Journal of the American College of Cardiology

repository_institution: Griffith University, Queensland, Australia - Griffith Research Online

repository_institution: University of California - eScholarship University of California

repository_normalized: California Digital Library - eScholarship

repositories: California Digital Library - eScholarship

repositories_institution: Griffith University, Queensland, Australia - Griffith Research Online

repositories_institution: University of California - eScholarship University of California

title: Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol

ReferenceCitation: Diaz R, Li QH, Bhatt DL, Bittner VA, Baccara-Dinet MT, Goodman SG, Jukema JW, Kimura T, Parkhomenko A, Pordy R, Reiner Ž, Roe MT, Szarek M, Tse HF, White HD, Zahger D, Zeiher AM, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. Intensity of statin treatment after acute coronary syndrome, residual risk, and its modification by alirocumab: insights from the ODYSSEY OUTCOMES trial. Eur J Prev Cardiol. 2021 Mar 23;28(1):33-43. doi: 10.1177/2047487320941987. Epub 2020 Jul 27.

name: Estudios Clínicos Latino América, Instituto Cardiovascular de Rosario, Argentina

name: Regeneron Pharmaceuticals Inc., Tarrytown, USA

name: Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, USA

name: Division of Cardiovascular Disease, University of Alabama at Birmingham, USA

name: Canadian VIGOUR Centre, University of Alberta, Canada

name: St Michael’s Hospital, University of Toronto, Canada

name: Department of Cardiology, Leiden University Medical Center, The Netherlands

name: Kyoto University, Graduate School of Medicine, Japan

name: MD Strazhesko Institute of Cardiology, AMS of Ukraine, Ukraine

name: University Hospital Center Zagreb, University of Zagreb, Croatia

name: Duke Clinical Research Institute, Duke University Medical Center, USA

name: State University of New York, Downstate School of Public Health, USA

name: Queen Mary Hospital, Hong Kong, Special Administrative Region of the People's Republic of China

name: Green Lane Cardiovascular Services, Auckland City Hospital, New Zealand

name: Soroka University Medical Center, Ben Gurion University of the Negev, Israel

name: Department of Medicine III, Goethe University, Germany

name: Division of Cardiology, University of Colorado School of Medicine, USA

name: Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, FACT (French Alliance for Cardiovascular Trials), and INSERM, France

name: Imperial College, Royal Brompton Hospital, UK

name: for the ODYSSEY OUTCOMES Committees and Investigators

journal_name: European Journal of Preventive Cardiology

ReferenceCitation: Schwartz GG, Szarek M, Bittner VA, Bhatt DL, Diaz R, Goodman SG, Jukema JW, Loy M, Manvelian G, Pordy R, White HD, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. Relation of Lipoprotein(a) Levels to Incident Type 2 Diabetes and Modification by Alirocumab Treatment. Diabetes Care. 2021 May;44(5):1219-1227. doi: 10.2337/dc20-2842. Epub 2021 Mar 15.

repository_institution: California Digital Library - eScholarship

repositories_institution: California Digital Library - eScholarship

title: Relation of Lipoprotein(a) Levels to Incident Type 2 Diabetes and Modification by Alirocumab Treatment

ReferenceCitation: Schwartz GG, Gabriel Steg P, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Manvelian G, Pordy R, Sourdille T, White HD, Szarek M; ODYSSEY OUTCOMES Committees and Investigators. Clinical Efficacy and Safety of Alirocumab After Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial. Circulation. 2021 Mar 16;143(11):1109-1122. doi: 10.1161/CIRCULATIONAHA.120.049447. Epub 2021 Jan 13.

name: Division of Cardiology, School of Medicine, University of Colorado, Aurora (G.G.S., M.S.).

name: Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, INSERM U1148, France (P.G.S.).

name: Brigham and Women’s Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (D.L.B.).

name: Division of Cardiovascular Disease, University of Alabama at Birmingham (V.A.B.).

name: Estudios Cardiológicos Latinoamérica, Instituto Cardiovascular de Rosario, Argentina (R.D.).

name: Canadian VIGOUR Centre, University of Alberta, Edmonton, and St. Michael’s Hospital, University of Toronto, Ontario, Canada (S.G.G.).

name: Department of Cardiology, Leiden University Medical Center, The Netherlands (J.W.J.).

name: Regeneron Pharmaceuticals Inc, Tarrytown, NY (Q.H.L., G.M., R.P.).

name: Green Lane Cardiovascular Services, Auckland City Hospital, New Zealand (H.D.W.).

name: CPC Clinical Research, University of Colorado School of Medicine, Aurora (M.S.).

name: State University of New York, Downstate School of Public Health, Brooklyn (M.S.).

name: For the ODYSSEY OUTCOMES Committees and Investigators

publisher: Ovid Technologies (Wolters Kluwer Health)

ReferenceCitation: Schmidt AF, Carter JL, Pearce LS, Wilkins JT, Overington JP, Hingorani AD, Casas JP. PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020 Oct 20;10:CD011748. doi: 10.1002/14651858.CD011748.pub3.

name: Institute of Cardiovascular Science; University College London; London UK

name: Department of Cardiology, Division Heart and Lungs; UMC Utrecht; Utrecht Netherlands

name: Department of Clinical Pharmacology and Therapeutics; University College London Hospital; London UK

name: Department of Non-communicable Disease Epidemiology; London School of Hygiene & Tropical Medicine; London UK

name: The Department of Medicine (Cardiology) and the Department of Preventive Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA

name: Medicines Discovery Catapult; Alderly Edge UK

name: Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC); VA Boston Healthcare System; Boston Massachusetts USA

repository_institution: University College London - UCL Discovery

repository_institution: University of Groningen / Centre for Information Technology - University of Groningen research database

repositories_institution: University College London - UCL Discovery

repositories_institution: University of Groningen / Centre for Information Technology - University of Groningen research database

title: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

ReferenceCitation: Szarek M, Bittner VA, Aylward P, Baccara-Dinet M, Bhatt DL, Diaz R, Fras Z, Goodman SG, Halvorsen S, Harrington RA, Jukema JW, Moriarty PM, Pordy R, Ray KK, Sinnaeve P, Tsimikas S, Vogel R, White HD, Zahger D, Zeiher AM, Steg PG, Schwartz GG; ODYSSEY OUTCOMES Investigators. Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial. Eur Heart J. 2020 Nov 21;41(44):4245-4255. doi: 10.1093/eurheartj/ehaa649.

name: Department of Epidemiology and Biostatistics, State University of New York, Downstate School of Public Health, 450 Clarkson Avenue, MS 43, Brooklyn, NY 11203, USA

name: Division of Cardiovascular Disease, University of Alabama at Birmingham, 701 19th Street South - LHRB 310, Birmingham, AL 35294, USA

name: Department of Cardiology, South Australian Health and Medical Research Institute, Flinders University and Medical Centre, South Australia 5042, Australia

name: Sanofi R&D, Global Development, 371 Rue du Professeur Blayac, 34080 Montpellier, France

name: Department of Medicine, Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

name: Estudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Paraguay 160, Rosario, Santa Fe, Rosario 2000, Argentina

name: Preventive Cardiology Unit, Department of Vascular Medicine, Division of Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, SI-1525 Ljubljana, Slovenia

name: Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia

name: Canadian VIGOUR Centre, University of Alberta, 87 Ave NW, Edmonton, Alberta T6G 2E1, Canada

name: Division of Cardiology, St. Michael’s Hospital, Room 6-034 Donnelly Wing, Toronto, Ontario M5B 1W8, Canada

name: Department of Cardiology, Oslo Universitetssykehus HF Ulleval, and University of Oslo, Problemveien 7, 0315 Oslo, Norway

name: Stanford Center for Clinical Research, Department of Medicine, Stanford University, 291 Campus Drive, Li Ka Shing Building, Stanford, CA 94305-5101, USA

name: Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands

name: Netherlands Heart Institute, Utrecht, the Netherlands

name: Clinical Pharmacology—University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA

name: Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA

name: Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, Reynolds Building, St Dunstans Road, London W6 8RP, UK

name: Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium

name: Sulpizio Cardiovascular Center, Division of Cardiovascular Medicine, University of California San Diego, 9434 Medical Center Dr, La Jolla, CA 92037, USA

name: Department of Medicine, University of Colorado Denver, 13001 E 17th Pl, Aurora, CO 80045, USA

name: Green Lane Cardiovascular Services, Auckland City Hospital, 5 Park Road, Grafton, Auckland 1142, New Zealand

name: Department of Cardiology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, PO Box 151 Beer Sheva 8410, Israel

name: Department of Medicine III, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany

name: Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Université de Paris, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, 46 Rue Henri Huchard, Paris 75018, France

name: National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, Sydney St, Chelsea, London SW3 6NP, UK

name: Division of Cardiology, University of Colorado School of Medicine, Box B130, Aurora, CO 80045, USA

repository_institution: University of Oslo - Duo Research Archive

repositories_institution: University of Oslo - Duo Research Archive

ReferenceCitation: Bhatt DL, Briggs AH, Reed SD, Annemans L, Szarek M, Bittner VA, Diaz R, Goodman SG, Harrington RA, Higuchi K, Joulain F, Jukema JW, Li QH, Mahaffey KW, Sanchez RJ, Roe MT, Lopes RD, White HD, Zeiher AM, Schwartz GG, Gabriel Steg P; ODYSSEY OUTCOMES Investigators. Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial. J Am Coll Cardiol. 2020 May 12;75(18):2297-2308. doi: 10.1016/j.jacc.2020.03.029.

repository_institution: London School of Hygiene and Tropical Medicine - LSHTM Research Online

repositories_institution: London School of Hygiene and Tropical Medicine - LSHTM Research Online

title: Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes

ReferenceCitation: Schwartz GG, Steg PG, Szarek M, Bittner VA, Diaz R, Goodman SG, Kim YU, Jukema JW, Pordy R, Roe MT, White HD, Bhatt DL; ODYSSEY OUTCOMES Committees and Investigators*. Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial. Circulation. 2020 May 19;141(20):1608-1617. doi: 10.1161/CIRCULATIONAHA.120.046524. Epub 2020 Mar 29.

name: Division of Cardiology, University of Colorado School of Medicine, Aurora (G.G.S.).

name: Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (P.G.S.).

name: University of Alabama at Birmingham (V.A.B.).

name: Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada (S.G.G.).

name: St. Michael’s Hospital, University of Toronto, ON, Canada (S.G.G.).

name: Leiden University Medical Center, The Netherlands (J.W.J.).

name: Regeneron Pharmaceuticals, Tarrytown, NY (R.P.).

name: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (M.T.R.).

name: Green Lane Cardiovascular Services Auckland City Hospital, New Zealand (H.D.W.).

name: For the ODYSSEY OUTCOMES Committees and Investigators*

title: Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome

ReferenceCitation: Bittner VA, Szarek M, Aylward PE, Bhatt DL, Diaz R, Edelberg JM, Fras Z, Goodman SG, Halvorsen S, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Moriarty PM, Moryusef A, Pordy R, Roe MT, Sinnaeve P, Tsimikas S, Vogel R, White HD, Zahger D, Zeiher AM, Steg PG, Schwartz GG; ODYSSEY OUTCOMES Committees and Investigators. Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome. J Am Coll Cardiol. 2020 Jan 21;75(2):133-144. doi: 10.1016/j.jacc.2019.10.057.

repository_institution: Universitat de Barcelona - Dipòsit Digital de la Universitat de Barcelona

repository_institution: University of Oulu - University of Oulu Repository - Jultika

repository_institution: Goethe University Frankfurt - Publication Server of Goethe University Frankfurt am Main

repositories_institution: Goethe University Frankfurt - Publication Server of Goethe University Frankfurt am Main

repositories_institution: Universitat de Barcelona - Dipòsit Digital de la Universitat de Barcelona

repositories_institution: University of Oulu - University of Oulu Repository - Jultika

title: Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome

ReferenceCitation: Szarek M, Steg PG, DiCenso D, Bhatt DL, Bittner VA, Budaj A, Diaz R, Goodman SG, Gotcheva N, Jukema JW, Pordy R, Roe MT, Sourdille T, White HD, Xavier D, Zeiher AM, Schwartz GG. Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial. Circ Cardiovasc Qual Outcomes. 2019 Nov;12(11):e005858. doi: 10.1161/CIRCOUTCOMES.119.005858. Epub 2019 Nov 11.

name: State University of New York, Downstate School of Public Health, Brooklyn, NY (M.S.).

name: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris and Paris University, Sorbonne Paris Cité, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris, France (P.G.S.).

name: National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, United Kingdom (P.G.S.).

name: Woodhull Medical Center, Brooklyn, NY (D.D.).

name: Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL (V.A.B.).

name: Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.).

name: Estudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.).

name: Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada and St Michael’s Hospital, University of Toronto, Ontario, Canada (S.G.G.).

name: MHAT “National Cardiology Hospital” EAD, Sofia, Bulgaria (N.G.).

name: Department of Cardiology, Leiden University Medical Center, the Netherlands (J.W.J.).

name: Regeneron Pharmaceuticals Inc, Tarrytown, NY (R.P.).

name: Green Lane Cardiovascular Services Auckland City Hospital, Auckland, New Zealand (H.D.W.).

name: St John’s Medical College, Bangalore, India (D.X.).

name: Department of Medicine III, Goethe University, Frankfurt am Main, Germany (A.M.Z.).

name: Division of Cardiology, University of Colorado School of Medicine, Aurora, CO (G.G.S.).

name: for the ODYSSEY OUTCOMES Committees and Investigators*

ReferenceCitation: Jukema JW, Zijlstra LE, Bhatt DL, Bittner VA, Diaz R, Drexel H, Goodman SG, Kim YU, Pordy R, Reiner Ž, Roe MT, Tse HF, Montenegro Valdovinos PC, White HD, Zeiher AM, Szarek M, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Investigators. Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES. Circulation. 2019 Dec 17;140(25):2054-2062. doi: 10.1161/CIRCULATIONAHA.119.043826. Epub 2019 Nov 11.

name: Department of Cardiology, Leiden University Medical Center, The Netherlands (J.W.J., L.E.Z.).

name: Brigham and Women’s Hospital Heart & Vascular Center and Harvard Medical School, Boston, Massachusetts (D.L.B.).

name: Estudios Cardiológicos Latinoamérica, Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.).

name: Landeskrankenhaus Feldkirch, Austria (H.D.).

name: Division of Angiology, Swiss Cardiovascular Center, University of Bern, Switzerland (H.D.).

name: St. Michael’s Hospital, University of Toronto, Ontario, Canada (S.G.G.).

name: Regeneron Pharmaceuticals Inc., Tarrytown, New York (R.P.).

name: University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia (Z.R.).

name: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina (M.T.R.).

name: Queen Mary Hospital, The University of Hong Kong (H-F.T.).

name: Unidad de Diagnostico Cardiologico, Guatemala City, Guatemala (P.C.M.V.).

name: Hospital General San Juan de Dios, Guatemala City, Guatemala (P.C.M.V.).

name: Green Lane Cardiovascular Services, Auckland City Hospital, Auckland, New Zealand (H.D.W.).

name: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Université de Paris, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris (P.G.S.).

repository_institution: University of Bern - Bern Open Repository and Information System

repositories_institution: University of Bern - Bern Open Repository and Information System

title: Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES

ReferenceCitation: Roe MT, Li QH, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Harrington RA, Jukema JW, Lopez-Jaramillo P, Lopes RD, Louie MJ, Moriarty PM, Szarek M, Vogel R, White HD, Zeiher AM, Baccara-Dinet MT, Steg PG, Schwartz GG. Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes. Circulation. 2019 Nov 5;140(19):1578-1589. doi: 10.1161/CIRCULATIONAHA.119.042551. Epub 2019 Sep 2.

name: Duke Clinical Research Institute, Durham, NC (M.T.R., R.D.L.).

name: Regeneron Pharmaceuticals, Tarrytown, NY (Q.H.L., M.J.L.).

name: Brigham and Women’s Hospital, Boston, MA (D.L.B.).

name: Estudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Argentina (R.D.).

name: St Michael’s Hospital, Toronto, Canada (S.G.G.).

name: Stanford University Medical Center, CA (R.A.H.).

name: Leiden University Medical Center, the Netherlands (J.W.J.).

name: Fundación Oftalmológica de Santander (FOSCAL), Medical School (UDES), Floridablanca, Colombia (P.L.-J.).

name: University of Kansas Medical Center, Kansas City, MO (P.M.M.).

name: State University of New York (SUNY) Downstate Medical Center, Downstate School of Public Health, Brooklyn (M.S.).

name: University of Colorado, Aurora (R.V., G.G.S.).

name: Sanofi, Montpellier, France (M.T.B.-D.).

name: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Université de Paris, FACT (French Alliance for Cardiovascular Trials), Institut National de la Santé et de la Recherche Médicale (INSERM) U1148, France (P.G.S.).

name: National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK (P.G.S.).

repository_institution: University of Southern Denmark - University of Southern Denmark Research Portal

repository_institution: Uppsala University - Uppsala University Publications

repository_institution: University of Antwerp - Institutional Repository University of Antwerp

repositories_institution: University of Antwerp - Institutional Repository University of Antwerp

repositories_institution: University of Southern Denmark - University of Southern Denmark Research Portal

repositories_institution: Uppsala University - Uppsala University Publications

ReferenceCitation: Goodman SG, Aylward PE, Szarek M, Chumburidze V, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Hanotin C, Harrington RA, Jukema JW, Kedev S, Letierce A, Moryusef A, Pordy R, Ramos López GA, Roe MT, Viigimaa M, White HD, Zeiher AM, Steg PG, Schwartz GG; ODYSSEY OUTCOMES Committees and Investigators. Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery. J Am Coll Cardiol. 2019 Sep 3;74(9):1177-1186. doi: 10.1016/j.jacc.2019.07.015.

title: Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery

ReferenceCitation: Ray KK, Colhoun HM, Szarek M, Baccara-Dinet M, Bhatt DL, Bittner VA, Budaj AJ, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Lopes RD, Moryusef A, Murin J, Pordy R, Ristic AD, Roe MT, Tuñón J, White HD, Zeiher AM, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial. Lancet Diabetes Endocrinol. 2019 Aug;7(8):618-628. doi: 10.1016/S2213-8587(19)30158-5. Epub 2019 Jul 1. Erratum in: Lancet Diabetes Endocrinol. 2019 Jul 8;:. Lancet Diabetes Endocrinol. 2019 Sep;7(9):e21.

ReferenceCitation: Steg PG, Szarek M, Bhatt DL, Bittner VA, Brégeault MF, Dalby AJ, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Ostadal P, Parkhomenko A, Pordy R, Roe MT, Tricoci P, Vogel R, White HD, Zeiher AM, Schwartz GG. Effect of Alirocumab on Mortality After Acute Coronary Syndromes. Circulation. 2019 Jul 9;140(2):103-112. doi: 10.1161/CIRCULATIONAHA.118.038840. Epub 2019 May 23. Erratum in: Circulation. 2019 Jul 23;140(4):e171.

name: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Université de Paris, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris, France (P.G.S.).

name: Division of Cardiovascular Disease, University of Alabama at Birmingham. (V.A.B.).

name: Sanofi, Paris, France (M.F.B., C.H., G.L.).

name: Milpark Hospital, Johannesburg, Republic of South Africa (A.J.D.).

name: Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada and St. Michael’s Hospital, University of Toronto, Canada (S.G.G.).

name: Stanford Center for Clinical Research, Department of Medicine, Stanford University, CA (R.A.H., K.W.M.).

name: Na Homolce Hospital, Prague, Czech Republic (P.O.).

name: Institute of Cardiology, Kyiv, Ukraine (A.P.).

name: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (M.T.R., P.T.).

name: Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC (M.T.R.).

name: For the ODYSSEY OUTCOMES Committees and Investigators†

title: Effect of Alirocumab on Mortality After Acute Coronary Syndromes

ReferenceCitation: Jukema JW, Szarek M, Zijlstra LE, de Silva HA, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Karpov Y, Moryusef A, Pordy R, Prieto JC, Roe MT, White HD, Zeiher AM, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial. J Am Coll Cardiol. 2019 Sep 3;74(9):1167-1176. doi: 10.1016/j.jacc.2019.03.013. Epub 2019 Mar 18.

title: Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome

ReferenceCitation: Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM; ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018 Nov 29;379(22):2097-2107. doi: 10.1056/NEJMoa1801174. Epub 2018 Nov 7.

name: From the Division of Cardiology, University of Colorado School of Medicine, Aurora (G.G.S.); Assistance Publique–Hôpitaux de Paris, Hôpital Bichat, Paris Diderot University, Sorbonne Paris Cité, FACT (French Alliance for Cardiovascular Trials), and INSERM Unité 1148 (P.G.S.), and Sanofi (C.H., G.L.) — all in Paris; the National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London (P.G.S.); the State University of New York Downstate School of Public Health, Brooklyn (M.S.), and...

repository_institution: DANS - Data Archiving and Networked Services - NARCIS - National Academic Research and Collaborations Information System

repositories_institution: University of Zurich - Zurich Open Repository and Archive

title: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

ReferenceCitation: Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG. Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial. Am Heart J. 2014 Nov;168(5):682-9. doi: 10.1016/j.ahj.2014.07.028. Epub 2014 Aug 7.

title: Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial

location_country: Macedonia, The Former Yugoslav Republic of

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