title: Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study

acronym: METINFO

summary: The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose. Second objectives are to estimate the real hospitalization rate related to metformin overdose and to identify the risk factors of a metformin overdose and especially the potential correlation between metformin blood concentration and overdose severity.

ReferenceCitation: Goonoo MS, Morris R, Raithatha A, Creagh F. Metformin-associated lactic acidosis: reinforcing learning points. BMJ Case Rep. 2020 Sep 2;13(9). pii: e235608. doi: 10.1136/bcr-2020-235608. Corrected and republished in: Drug Ther Bull. 2021 Aug;59(8):124-127.

ReferenceCitation: Walz L, Jönsson AK, Ahlner J, Östgren CJ, Druid H. Metformin - Postmortem fatal and non-fatal reference concentrations in femoral blood and risk factors associated with fatal intoxications. Forensic Sci Int. 2019 Oct;303:109935. doi: 10.1016/j.forsciint.2019.109935. Epub 2019 Aug 28.

ReferenceCitation: Taub ES, Hoffman RS, Manini AF. Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. Am J Emerg Med. 2019 Dec;37(12):2205-2208. doi: 10.1016/j.ajem.2019.03.033. Epub 2019 Mar 23.


title: Prognostic Impact of the Inflammatory Microenvironment in Atypical Meningiomas

summary:
Atypical meningiomas represent 15% of meningiomas. They present a high rate of recurrence, and therapeutic strategies are limited. There is a need for novel treatment strategies, such as immuotherapy.

This is a retrospective study including 84 patients with primary diagnosis of atypical meningiomas. The presence of T cells (CD4, CD8, Treg and memory T cells) and mature dendritic cells will be quantified on whole tissue sections stained by immunohistochemistry (CD4, CD8, FOXP3, CD45RO and CD208).

This could allow us to identify novel biomarkers for survival, and facilitate the selection of patients who may benefit from immunotherapeutic modalities.

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

study_type: Observational

time_perspective: Retrospective

enrollment_type: Anticipated

lead_sponsor: Central Hospital, Nancy, France

lead_sponsor_type: academique

status_simplified: Ongoing


title: Multimodal IMAgery (Echocardiography and Cardiac MRI) Characterization of Cardiac Damage and Severity After COVID-19 Infection

acronym: IMACovid

summary:
Coronavirus Disease 2019 (COVID-19) is an infection caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which affects multiple organ system particularly the lung and heart. Indeed, SARS CoV-2 has various cardiac manifestations which are associated with higher mortality and morbidity. Cardiac involvement, based on elevated levels of myocardial enzymes, have been described in 20 to 30% of COVID-19 infection. However, the physiopathological mechanisms of myocardial injury remains unclear. Main hypothesis include inflammation and cytokine storm, hypercoagulability and vascular thrombosis, inflammation or stress leading to coronary plaque rupture (type I myocardial infarction), supply-demand mismatch and hypoxemia resulting in myocardial damage (type II myocardial infarction) ...

Two patterns can be identified : ischemic or non-ischemic pattern including myocarditis, stress induced cardiomyopathy, thrombo-embolic disease. However, the consequences of myocardial damage after confirmed COVID-19 infection are unknown at medium to long term prognosis.

Data are needed to identify myocardial damage and to guide effective therapies and follow-up (use of ACE inhibitor, beta-blockers, steroids...? ) In this study, the investigators proposed to collect multimodal cardiac imaging including MRI (Magnetic Resonance Imaging) and TTE (Transthoracic echocardiogram) in order to identify and characterize cardiac injury as ischemic or non-ischemic pattern, to better assess risk stratification and to guide effective therapies if necessary.

ReferenceType: result

ReferenceCitation: Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585. Erratum in: JAMA. 2021 Mar 16;325(11):1113.

name: Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Wang

full_name: Dawei Wang

given: Dawei

sequence: first

family: Hu

full_name: Bo Hu

given: Bo

sequence: additional

full_name: Chang Hu

given: Chang

family: Zhu

full_name: Fangfang Zhu

given: Fangfang

family: Liu

full_name: Xing Liu

given: Xing

family: Zhang

full_name: Jing Zhang

given: Jing

full_name: Binbin Wang

given: Binbin

family: Xiang

full_name: Hui Xiang

given: Hui

name: Department of Pulmonary Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Cheng

full_name: Zhenshun Cheng

given: Zhenshun

name: Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Xiong

full_name: Yong Xiong

given: Yong

name: Department of Emergency Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Zhao

full_name: Yan Zhao

given: Yan

name: Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Li

full_name: Yirong Li

given: Yirong

name: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

full_name: Xinghuan Wang

given: Xinghuan

family: Peng

full_name: Zhiyong Peng

given: Zhiyong

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: JAMA

oa_colors: green other

oa_host_type: publisher;repository

evidence: open (via free pdf)

host_type: publisher

license_normalized: no license

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

publisher: American Medical Association (AMA)

publisher_dissemination: American Medical Association

publisher_group: American Medical Association

publisher_normalized: American Medical Association

title: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

ReferenceCitation: Bavishi C, Bonow RO, Trivedi V, Abbott JD, Messerli FH, Bhatt DL. Special Article - Acute myocardial injury in patients hospitalized with COVID-19 infection: A review. Prog Cardiovasc Dis. 2020 Sep - Oct;63(5):682-689. doi: 10.1016/j.pcad.2020.05.013. Epub 2020 Jun 6. Review.

family: Bavishi

full_name: Chirag Bavishi

given: Chirag

family: Bonow

full_name: Robert O. Bonow

given: Robert O.

family: Trivedi

ReferenceCitation: Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, Brown TS, Der Nigoghossian C, Zidar DA, Haythe J, Brodie D, Beckman JA, Kirtane AJ, Stone GW, Krumholz HM, Parikh SA. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. J Am Coll Cardiol. 2020 May 12;75(18):2352-2371. doi: 10.1016/j.jacc.2020.03.031. Epub 2020 Mar 19. Review.

journal_name: Journal of the American College of Cardiology

ReferenceCitation: Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, Cani DS, Cerini M, Farina D, Gavazzi E, Maroldi R, Adamo M, Ammirati E, Sinagra G, Lombardi CM, Metra M. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 Jul 1;5(7):819-824. doi: 10.1001/jamacardio.2020.1096.

name: Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy

name: Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy

name: “De Gasperis” Cardio Center and Transplant Center, Niguarda Hospital, Milan, Italy

name: Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy

repository_institution: Università degli Studi di Brescia - Institutional Research Information System

ReferenceCitation: Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B, Amanullah A. Myocardial injury and COVID-19: Possible mechanisms. Life Sci. 2020 Jul 15;253:117723. doi: 10.1016/j.lfs.2020.117723. Epub 2020 Apr 28. Review.

ReferenceCitation: Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Epub 2020 Feb 18. Erratum in: Lancet Respir Med. 2020 Feb 25;:.

ReferenceCitation: Barton LM, Duval EJ, Stroberg E, Ghosh S, Mukhopadhyay S. COVID-19 Autopsies, Oklahoma, USA. Am J Clin Pathol. 2020 May 5;153(6):725-733. doi: 10.1093/ajcp/aqaa062. Erratum in: Am J Clin Pathol. 2020 May 5;153(6):852.

name: Office of the Chief Medical Examiner, Oklahoma City, OK

name: Section of Thoracic Imaging, Imaging Institute, Cleveland Clinic, Cleveland, OH

name: Department of Pathology, Cleveland Clinic, Cleveland, OH

title: COVID-19 Autopsies, Oklahoma, USA

ReferenceCitation: Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, Atar D, Kaski JC, Sechtem U, Tornvall P; WG on Cardiovascular Pharmacotherapy. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017 Jan 14;38(3):143-153. doi: 10.1093/eurheartj/ehw149.

ReferenceCitation: Imazio M, Klingel K, Kindermann I, Brucato A, De Rosa FG, Adler Y, De Ferrari GM. COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? Heart. 2020 Aug;106(15):1127-1131. doi: 10.1136/heartjnl-2020-317186. Epub 2020 Jun 4. Review.

ReferenceCitation: Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Apr 7;323(13):1239-1242. doi: 10.1001/jama.2020.2648.

name: Chinese Center for Disease Control and Prevention, Beijing, China


title: Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study

summary:
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage, cerebral venous thrombosis.

Initially considered as a lifesaving therapy, benefits in terms of survival were shown compared to medical treatment alone.

However, despite a better survival, morbidity and poor neurological outcome are frequent among survivors.

The objective of the study is to identify initial good neurological outcome factors after decompressive craniectomy in a large series of patients, in order to argue surgical and intensive care decisions, considering expected benefit and quality of life.

status: Completed

study_completion_date_type: Actual

enrollment_type: Actual

ipd_sharing: No

intervention_type: Procedure

status_simplified: Completed


title: Postural Control Quality in Chiari I Malformation: Evaluation in a Pediatric Population

summary:
BACKGROUND: Chiari I malformation is a rare disease characterized by cerebellar amygdalae descent under the level of the foramen magnum. It causes troubles in cerebrospinal fluid circulation and direct compression on brainstem, producing characteristic headaches, neurological impairment and syringomyelia. Surgery is the only treatment, indicated when symptomatology exists. However, sometimes patients complaint about atypical symptoms that are difficult to interpret.

We would like to study one of these atypical symptoms, gait imbalance, in a pediatric population thanks to a computerized dynamic posturography (Equitest®).

METHOD: infants from 6 to 18 years of age presenting a radiologically confirmed Chiari I malformation will be included in the study. We will compare posturographic results of patients which will be operated on with the results of the patients which will not; furthermore, we will compare preoperative and postoperative results in operated patients.

RESULTS: 19 patients have been enrolled in the study, and data have been collected for 12 of them. Seven patients belong to operated population.

CONCLUSIONS: even if enrolment of the patients is satisfactory, disposable data are not enough to perform statistical analysis and to put forward any conclusion.

time_perspective: Prospective

intervention_type: Diagnostic Test


title: Conséquences of the COVID-19 Lockdown Measures on the CHRU Nancy

summary: The first period of COVID 19 Lockdown Measures (From 18 March to 11 may 2020) change the French people way of life and their medicine knowledges. A study which evaluates the Nancy's Pediatric emergencies population utilization during this time could detect pathological changes. The medical impact of Home Confinement will show an increase (trauma, maltreatment) or decrease (virus disease) of several pathology. The study aims to help clinicians to the children care if another time of Home Confinement happened. The main objective is to evaluate the behavioural changes and the reason consultation in Nancy's Pediatric Emergencies from 18 March to 30 June 2020 comparate to the same time in 2019. We will continue the search after the end of Home Confinement until 30 June 2020 to evaluate what happened just after.

ipd_sharing: Undecided


title: Assessment of Contrast Enhancement Boost for the Direct Identification of Pulmonary Emboli in Thoracic CT Angiography

summary:
Pulmonary embolism is a common cardiovascular disease and thoracic CT angiography is currently considered the gold standard for its non-invasive diagnosis. However, the diagnostic performance of CT angiography can be hampered by an insufficient enhancement of pulmonary arteries. Contrast Enhancement Boost (CE Boost) is a post-processing technique using an iodine density map to artificially improve pulmonary artery enhancement.

This retrospective study compares standard CT-angiography images with CE Boost images to assess the potential improvement of diagnostic performance for the detection of pulmonary embolism.


title: Cross Sectional Relation of Digital Vascular Function Measured by EndoPAT® in elderlY Patients to Arterial Stiffness

acronym: ENDY

summary:
Due to the aging of populations worldwide, we observe an increase of age-related diseases and loss of autonomy with consequent personal, social, medical and economic implications. The aging population is a target for geriatric medicine, necessitating the development of specific diagnostic and therapeutic approaches in order to estimate cardio vascular risk in these individuals.

It is thought that arterial stiffening and endothelial dysfunction are among the earliest vascular properties altered with the onset of cardiovascular disease. Moreover aging is characterized by progressive fragmentation and break down of the elastic components of the aortic media, which are partially replaced by highly cross-linked collagen leading to stiffening, dilation, and elongation of the aorta . A major underlying mechanism of these modifications is endothelial dysfunction due to high oxidative stress and low-grade inflammation. Reactive hyperemia index (RHI), a key outcome of peripheral arterial tonometry (PAT) has recently become a reliable tool to measure microvascular endothelial function. Some studies have recently demonstrated the interest to measure in elderly patients arterial stiffness parameters in order to prevent loss of autonomy. This cross sectional study aimed at demonstrating the link between arterial stiffness evaluated by pulse wave velocity and endothelial dysfunction evaluated by RHI to implement the tools of cardio vascular risk evaluation in a population of elderly patients referred in a geriatric day hospital.

intervention_type: Device


title: Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam

acronym: AIMANT

summary: The purpose of this study is to evaluate the optimization of MRI acquisition sequences.

study_type: Interventional

primary_purpose: Other

intervention_type: Other


title: Positive Diagnosis of Heart Failure With Preserved LVEF by Exercise Pulmonary Ultrasound.

acronym: E-LUS

summary:
The E-LUS study is a prospective, non randomised, monocenter case-control study.

The main objective is to evaluate the association of exercise lung ultrasound data acquired during a stress test on a bicycle ergometer with the diagnosis of heart failure with preserved ejection fraction (HFpEF).


title: Evaluation of the Clinical and Functional Results Obtained After a Total Elbow Arthroplasty, All Indications Combined

summary: Analysis of clinical and functional outcomes after a total elbow arthrosplasty, all indications combined, with a minimum follow up of 24 months The hypothesis is that there a significant improvement after an elbow replacement, no matter what the surgery indication is

status: Active, not recruiting


title: First-time Fathers' Experiences of Childbirth in Lorraine.

acronym: PRIMIPERE

summary:
The primary aim of this study is to evaluate first time father's experience during childbirth in three different maternity hospitals in Lorraine.

Secondary aims of this study is to identify domains that need improvement in order to enhance fathers's experience during childbirth.

ReferenceCitation: Premberg Å, Carlsson G, Hellström AL, Berg M. First-time fathers' experiences of childbirth--a phenomenological study. Midwifery. 2011 Dec;27(6):848-53. doi: 10.1016/j.midw.2010.09.002. Epub 2010 Oct 16.

family: Premberg

full_name: Åsa Premberg

given: Åsa

family: Carlsson

full_name: Gunilla Carlsson

given: Gunilla

family: Hellström

full_name: Anna-Lena Hellström

given: Anna-Lena

family: Berg

full_name: Marie Berg

given: Marie

journal_name: Midwifery

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

title: First-time fathers’ experiences of childbirth—A phenomenological study

ReferenceCitation: Premberg Å, Taft C, Hellström AL, Berg M. Father for the first time--development and validation of a questionnaire to assess fathers' experiences of first childbirth (FTFQ). BMC Pregnancy Childbirth. 2012 May 17;12:35. doi: 10.1186/1471-2393-12-35.

family: Taft

full_name: Charles Taft

given: Charles

currency_apc_doaj: GBP

journal_name: BMC Pregnancy and Childbirth

oa_colors: green gold

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer

publisher_group: Springer

publisher_normalized: Springer

title: Father for the first time - development and validation of a questionnaire to assess fathers’ experiences of first childbirth (FTFQ)

ReferenceCitation: Capponi I, Carquillat P, Premberg Å, Vendittelli F, Guittier MJ. [Translation and validation in French of the First-Time Father Questionnaire]. Gynecol Obstet Fertil. 2016 Sep;44(9):480-6. doi: 10.1016/j.gyobfe.2016.07.011. Epub 2016 Aug 24. French.

family: Capponi

full_name: I. Capponi

given: I.

family: Carquillat

full_name: P. Carquillat

given: P.

full_name: Å. Premberg

given: Å.

family: Vendittelli

full_name: F. Vendittelli

given: F.

family: Guittier

full_name: M.-J. Guittier

title: Vécu de l’accouchement par les pères : traduction et validation transculturelle du First-Time Father Questionnaire sur un échantillon francophone


title: Intérêt de la réinterprétation Des CNV de Signification Inconnue Mis en évidence Par ACPA

acronym: ReAC

summary: We aim to assess the usefulness of systematic reinterpretation of CNV of unknown significance. To investigate this question we will study all CNV of unknown significance detected between 2010 and 2017.

ReferenceType: background

ReferenceCitation: Palmer E, Speirs H, Taylor PJ, Mullan G, Turner G, Einfeld S, Tonge B, Mowat D. Changing interpretation of chromosomal microarray over time in a community cohort with intellectual disability. Am J Med Genet A. 2014 Feb;164A(2):377-85. doi: 10.1002/ajmg.a.36279. Epub 2013 Dec 5.

intervention_type: Genetic


title: Kinetics Study of the Urinary Cortisol Elimination in Athletic Subjects After Knee Intra-articular Infiltration With Triamcinolone Acetonide

acronym: SporTRIA

summary:
Joint and abarticular glucocorticoid therapy infiltration are common in sports traumatology, but it can cause problems under global anti-doping legislation. Particularly, if the possibility of systemic passage is proven, the glucocorticoïdes urinary kinetics elimination should be clarified.

The study purpose is to determine the time to normalize glucocorticoids value in urinary sampling following intra-articular ultrasound-guided infiltration of Triamcinolone acetonide

primary_purpose: Screening

ReferenceType: derived

ReferenceCitation: Allado E, Poussel M, Gambier N, Saunier V, Starck M, Buisson C, Cinquetti G, Albuisson E, Chenuel B. SporTRIA study-a multicentre trial protocol for excretion kinetics of triamcinolone acetonide following sport-related intra-articular injections in knees: definitions of the washout periods. BMJ Open. 2021 Jun 9;11(6):e047548. doi: 10.1136/bmjopen-2020-047548.

family: Allado

full_name: Edem Allado

given: Edem

family: Poussel

full_name: Mathias Poussel

given: Mathias

family: Gambier

full_name: Nicolas Gambier

given: Nicolas

family: Saunier

full_name: Véronique Saunier

given: Véronique

family: Starck

full_name: Marjorie Starck

given: Marjorie

family: Buisson

full_name: Corinne Buisson

given: Corinne

family: Cinquetti

full_name: Gael Cinquetti

given: Gael

family: Albuisson

full_name: Eliane Albuisson

given: Eliane

family: Chenuel

full_name: Bruno Chenuel

given: Bruno

journal_name: BMJ Open

license: cc-by-nc

license_normalized: cc-by-nc

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

title: SporTRIA study—a multicentre trial protocol for excretion kinetics of triamcinolone acetonide following sport-related intra-articular injections in knees: definitions of the washout periods

location_facility: Centre Hospitalier Régional Universitaire de Nancy.

intervention_type: Drug


title: Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery Biopsy: a Monocentric Retrospective Study

summary: Temporal artery biopsy is a useful tool helping to the diagnosis of giant cell arteritis. However, other diagnoses might be associated with abnormal temporal artery biopsy. The purpose of this study is to describe the frequency of giant cell arteritis differential diagnoses with positive temporal artery biopsy.


title: EvaLuation de l'Apport de l'Irm Virtuelle Sur la qualité de la Prise en Charge Des Enfants en Irm

acronym: LIVE

summary:
The access to MRI examination is limited due to the duration of the acquisitions, the noise and the narrow patient space of the device. A child can, therefore, be anxious, less cooperative and move more during the acquisition, affecting the quality of the examination and the medical diagnosis. General anesthesia or sedation, may be considered to obtain diagnostic quality examinations. Our hypothesis is that a scenario as close as possible to reality to prepare children before the MR exam could reduce their anxiety, improve the quality of the exams and reduce its duration.

The purpose of this study is to evaluate the effect of virtual reality on MRI exam preparation to reduce the anxiety of children (aged from 6 to 12 years) who are referred to their first MRI exam, as compared to the current practice.

design_allocation: Randomized


title: Incidence of BRUE Among the Hospitalized Infants: Towards a Change in Medical Practices?

summary:
The malaise of the infant represents a polymorphic pathology in its clinical presentation.

Due to the young age of the patients concerned and the parental anxiety generated, hospital management is necessary, for clinical and paraclinical evaluation and monitoring.

The practice of complementary examinations is guided by personal and family history, and the precise description of the discomfort as well as clinical examination of the child and assessment of his vital parameters.

However, in view of the particular terrain represented by infants under one year of age, a number of tests are carried out systematically, and therefore empirically, because they are not guided by the clinic.

These various tests can be invasive, anxiety-provoking for parents and generate a significant additional cost during hospital management.

An evaluation of the indication and interest of these tests is necessary in order to propose a homogeneous clinical and paraclinical management of the discomfort of the infant, in particular of discomforts of type BRUE (Brief Resolved Unexplained Events), as described in the 2016 American Academy of Pediatrics (AAP) recommendations.


title: Contribution of Contrast Enhanced Ultrasound in the Diagnosis of Adnexal Torsion: a Prospective Comparative Pilot Study

acronym: AGATA

summary:
Clinical diagnosis of adnexal torsion is difficult because the symptomatology is dominated by abrupt onset pelvic pain, an aspecific sign which does not allow a diagnosis of certainty to be made.

To confirm the diagnosis, the reference examination is pelvic ultrasound with Doppler flow analysis. However, its intake is low, its sensitivity varies from 46 to 73% depending on the studies. Other imaging techniques have been considered, such as MRI, with a sensitivity far superior to ultrasound, but its difficult accessibility, in particular in the context of an emergency, makes it unusable in clinical practice.

The use of ultrasound with the injection of an ultrasound contrast agent, strict intravascular, seems to be an interesting technique to assess the perfusion parameters of the ovary and improve the diagnostic sensitivity of the adnexal torsion. Its interest has already been demonstrated in the diagnosis of testicular torsion in animals but to date, no study has evaluated its contribution in adnexal torsion.

design_allocation: Non-Randomized

primary_purpose: Diagnostic

location_facility: Centre Hospitalier Régional Universitaire de Nancy


title: Study of the Acceptability of a New Distance-learning Tool for Functional Insulin Therapy "MyFIT" by Patients With Type 1 Diabetes (T1D) and by Healthcare Professionals

acronym: MyFIT

summary:
The investigators developed an on-line learning tool "MyFIT" enabling to patients with T1D to acquire the knowledge and skills for practicing functional insulin therapy from their home.

The aim of the present study is to evaluate the acceptability of this new learning modality via the tool "MyFIT" by the patients and by the health professionnals.


title: CT Abnormalities Evocative of Lung Infection Are Associated With Lower 18F-FDG Uptake in Confirmed COVID-19 Patients

summary: CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on 18F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing.


title: Study of the Preventable Passage of Patients Over 75 Years of Age to the Emergency Room of the CHRU of Nancy

summary:
The adult emergency service of the Nancy CHRU welcomes an average of 135 visits per day. Approximately 18% are patients over 75 years old, among them 45% go home at the end of their care. The mobile geriatric liaison team intervenes with these patients at the request of the emergency doctors before they return home in order to identify their fragility and implement appropriate measures.

We wish to know the characteristics of these avoidable passages in order to propose preventive measures upstream of these passages. To do this, we need to know the characteristics of those patients with an avoidable passage.


title: Evaluation of the Couple's Sexuality During a Pregnancy Resulting From Medically Assisted Procreation and Comparison With Sexuality During a Spontaneous Pregnancy

summary: We wish to evaluate sexuality during pregnancy between spontaneous pregnancies and resulting from assisted procreation The literature is poor on thie subject

study_start_date_type: Anticipated


title: Multicenter Retrospective Study Evaluating the Impact of Early Palliative Care on the Survival of Patients With Locally Advanced and / or Metastatic Cholangiocarcinoma (CCK)

summary: The prognosis for cholangiocarcinoma is bad. Potentially, early management by a palliative care team could increase overall survival. We will also assess whether early management by a palliative care team could impact progression-free survival, the place of death and the date of the last chemotherapy, in particular to avoid unnecessary chemotherapy cures in an imminent end of life

status: Not yet recruiting


title: Birth Experience During COVID-19 Confinement (Confinement and Fostering Intrapartum Care)

acronym: CONFINE

summary: Different studies have demonstrated that the absence of companionship during labor and childbirth may be responsible for a negative birth experience, an increased risk of postnatal depression and/or post traumatic stress disorders. These situation may also have a negative impact on mother-child interaction, on marital and family relationship and on the rate of maternal suicide in postpartum. However, these previous results cannot be extrapolated in the current context where the absence of the companionship is imposed by the confinement framework. The objective of the CONFINE study is to assess, for the first time, the birth experience of women in the context of limited social support in the immediate post-partum period due to confinement, as well as the associated over-risk of mental disorders, compared to a post-partum without social restriction.

ReferenceCitation: Bertholdt C, Epstein J, Banasiak C, Ligier F, Dahlhoff S, Olieric MF, Mottet N, Beaumont M, Morel O. Birth experience during COVID-19 confinement (CONFINE): protocol for a multicentre prospective study. BMJ Open. 2020 Dec 10;10(12):e043057. doi: 10.1136/bmjopen-2020-043057.

apc_source: openAPC

family: Bertholdt

full_name: Charline Bertholdt

given: Charline

family: Epstein

full_name: Jonathan Epstein

given: Jonathan

family: Banasiak

full_name: Claire Banasiak

given: Claire

family: Ligier

full_name: Fabienne Ligier

given: Fabienne

family: Dahlhoff

full_name: Sandra Dahlhoff

given: Sandra

family: Olieric

full_name: Marie France Olieric

given: Marie France

family: Mottet

full_name: Nicolas Mottet

family: Beaumont

full_name: Marine Beaumont

given: Marine

family: Morel

full_name: Olivier Morel

given: Olivier

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

repository_normalized: HAL

repositories:
HAL
PubMed Central

ipd_sharing: Yes

ipd_sharing_description: All data generated during this study will be made available via CIC-EC, CHRU Nancy, Nancy- FRANCE in accordance with protocol promotor. Data obtained from this study will be deposited at CIC-EC Nancy where they will be maintained for a minimum of 15 years.


title: Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation: Evaluation de la Congestion à la Sortie d'Hospitalisation Pour Insuffisance Cardiaque aiguë à Fraction d'éjection altérée ou modérément altérée

acronym: AHF-CODE-R

summary:
The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure.

The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.


title: Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation: Evaluation de la Congestion à la Sortie d'Hospitalisation Pour Insuffisance Cardiaque aiguë à Fraction d'éjection préservée

acronym: AHF-CODE-P

summary:
The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure.

The main objective of the AHF-CODE preserved study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.


title: MRI Screening of Placenta Adhesion Abnormalities

acronym: DIANE

summary:
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during delivery that increase the risk of intraoperative massive bleeding, hysterectomy and even maternal death. Ultrasound is the standard modality for diagnosing PAA, but Magnetic Resonance Imaging (MRI) has been increasingly performed in the case of inconclusive sonographic findings. However, standard morphological MRI sequences appear as insufficient to improve the sensitivity and specificity values for detecting PAA, while quantitative MRI may be more efficient.

The main objective of this study is to characterize the diagnostic performance of quantitative MRI parameters (mainly Apparent Diffusion Coefficient, T2 and T2*) reflecting placental perfusion and/or oxygenation at high field, without injection of gadolinium-based agent, for the detection of PAA in women with ongoing pregnancy between 30 and 38 weeks of gestation.


title: Impact of Bariatric Surgery in Patients With Morbid Obesity. Prospective Study With Comparison Before and After

acronym: IVBIA

summary:
The main objective is to compare the prevalence of anal incontinence (AI) before and after bariatric surgery in obese patients.

Inclusion: Patients who are scheduled for a bariatric surgical procedure after a multidisciplinary evaluation for about 1 year (following french national recommendations).

Primary objective: After inclusion, all patients will fill in a specific self-questionnaire evaluating AI (PFDI-20 score) before surgery and at 6 months after surgery.

Investigators will evaluate the prevalence of anal incontinence before and at 6months after surgery using this PFDI- 20 score.

In those patients with preoperative anal incontinence (only in patients with 3 positive answers to question n°9,10, and 11 of PFDI-20 score self-questionnaire), a pelvic MRI will be performed before and at 6 months after surgery. Consequently, no further imaging exam will be performed in patients without preoperative anal incontinence (less than 3 positive answers to question n°9,10, and 11),

Secondary objectives:

to evaluate the AI severity variation before and at 6 months after bariatric surgery regarding the percentage of postoperative weight loss.
to compare the quality of life (PFIQ-7 score) related to AI day before and at 6 months after bariatric surgery.

location_facility: CHRU Nancy - Département Chirurgie Viscérale, Métabolique et Cancérologique CVMC (7ème étage)


title: Pertinence of Pediatric Message Delivered to Parents During Antenatal Consultations

acronym: INFONEO

summary:
Antenatal consultations are experienced as traumatic for many couples. Moreover, when informations are given urgently ; comprehension and psychological impact aren't well evaluate.

This project aims to evaluate comprehension and psychological impact, for both members of the couple, when informations are provided urgently or during usual consultations.


title: Creation of a Pace-mapping Atlas on Healthy and Pathological Hearts

acronym: ATLAS

summary: Aim of this study is to collect data from pace mapping performed in three groups of patients : patients presenting ventricular tachycardia and infarction history, patients presenting infarction history without presenting ventricular tachycardia, and in patients without structural heart disease.

ReferenceCitation: de Chillou C, Groben L, Magnin-Poull I, Andronache M, MagdiAbbas M, Zhang N, Abdelaal A, Ammar S, Sellal JM, Schwartz J, Brembilla-Perrot B, Aliot E, Marchlinski FE. Localizing the critical isthmus of postinfarct ventricular tachycardia: the value of pace-mapping during sinus rhythm. Heart Rhythm. 2014 Feb;11(2):175-81.


title: Veno-arterial Extracorporeal Membrane Oxygenation Support Prior to Left Ventricular Assist Device Implantation : Initial Patients Characteristics and 6 Month Follow-up, a Retrospective Study (2013-2017) (LVAD-ECMO)

acronym: LVAD-ECMO

summary:
Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a circulatory failure occures. VA-ECMO main indication is refractory cardiogenic shock whatever the etiology. Current medical care of terminal cardiac failure includes use of long-term mechanical circulatory support devices (MCSD) such as Left Ventricular Assist Device (LVAD). LVAD therapy may lead to heart transplant (bridge to transplantation), to recovery (bridge to recovery) or to permanent implantation (destination therapy). Few patients with refractory cardiogenic shock treated with VA-ECMO may secondarily need a long term MCSD with LVAD.

LVAD long-term heart assist showed interesting survival rate when implantation occured (71% after 2 years follow-up and 45% after 4 years follow-up) out of acute heart failure situation. There are only few datas concerning LVAD implantion during refractory cardiogenic shock, with a mortality between 20 to 50% in different studies.

In this way, in comparaison of current few datas on the subject of LVAD implantation under VA-ECMO, the investigators (15 french-speacking centers) would retrospectively describe a large population.

status: Unknown status

status_simplified: Unknown


title: Characterization of Movements Occurring During Sleep in Very Premature Neonates: Relationship With Neurodevelopmental Outcome

acronym: DODOPREMA

summary: Sleep is a key factor for normal brain development of the newborn. However, it is poorly studied and little is known about its characterization, especially in premature infants. Body movements during sleep are easy to evaluate but studies on their relationship to normal sleep states are scarce and limited. This project aims to characterize body movements during sleep, assessed by electroencephalography, in very premature infants. Then, a correlation between body movements, sleep organization and neurodevelopmental outcome will be evaluated at 3 years of age.


title: Registre Tumeurs Endocrine - Eurocrine

acronym: eurocrine

summary: This registry aims to collect informations about patients with endocrine tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube) who undergo endocrine surgical procedures. This registry is part of the Eurocrine Project.

ReferenceCitation: Greilsamer T, Nomine-Criqui C, Thy M, Ullmann T, Zarnegar R, Bresler L, Brunaud L. Robotic-assisted unilateral adrenalectomy: risk factors for perioperative complications in 303 consecutive patients. Surg Endosc. 2019 Mar;33(3):802-810. doi: 10.1007/s00464-018-6346-2. Epub 2018 Jul 11.

family: Greilsamer

full_name: Tristan Greilsamer

given: Tristan

family: Nomine-Criqui

full_name: Claire Nomine-Criqui

family: Thy

full_name: Michaël Thy

given: Michaël

family: Ullmann

full_name: Timothy Ullmann

given: Timothy

family: Zarnegar

full_name: Rasa Zarnegar

given: Rasa

family: Bresler

full_name: Laurent Bresler

given: Laurent

family: Brunaud

full_name: Laurent Brunaud

journal_name: Surgical Endoscopy

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature


title: EEG Analysis During Light Propofol Sedation

acronym: MOTANA

summary: The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal. EEG signals will be recorded during the realization of intentional movements and movement intentions by the healthy volunteers, as well as during median nerve stimulation before and during propofol perfusion according to a target control infusion. (0 µg/mL; 0.5 µg/mL and 1 µg/mL).

primary_purpose: Basic Science

ReferenceCitation: Blokland YM, Farquhar JD, Mourisse J, Scheffer GJ, Lerou JG, Bruhn J. Towards a novel monitor of intraoperative awareness: selecting paradigm settings for a movement-based brain-computer interface. PLoS One. 2012;7(9):e44336. doi: 10.1371/journal.pone.0044336. Epub 2012 Sep 6.

ReferenceCitation: Blokland Y, Farquhar J, Lerou J, Mourisse J, Scheffer GJ, Geffen GJ, Spyrou L, Bruhn J. Decoding motor responses from the EEG during altered states of consciousness induced by propofol. J Neural Eng. 2016 Apr;13(2):026014. doi: 10.1088/1741-2560/13/2/026014. Epub 2016 Feb 9.

ReferenceCitation: Lindig-León C, Bougrain L. Comparison of sensorimotor rhythms in EEG signals during simple and combined motor imageries over the contra and ipsilateral hemispheres. Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:3953-6. doi: 10.1109/EMBC.2015.7319259.

ReferenceCitation: Rimbert S, Schmartz D, Bougrain L, Meistelman C, Baumann C, Guerci P. MOTANA: study protocol to investigate motor cerebral activity during a propofol sedation. Trials. 2019 Aug 28;20(1):534. doi: 10.1186/s13063-019-3596-9.

family: Rimbert

full_name: Sébastien Rimbert

given: Sébastien

family: Schmartz

full_name: Denis Schmartz

given: Denis

family: Bougrain

full_name: Laurent Bougrain

family: Meistelman

full_name: Claude Meistelman

given: Claude

family: Baumann

full_name: Cédric Baumann

given: Cédric

family: Guerci

full_name: Philippe Guerci

given: Philippe

journal_name: Trials

repository_institution: Université Libre de Bruxelles - Dépôt institutionnel de l'Université libre de Bruxelles

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repositories:
HAL
PubMed Central
dipot.ulb.ac.be

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

location_facility: Department of Anesthesiology and Critical Care Medicine - University Hospital of Nancy


title: First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography (SPIRIT): A Prospective Study in Nulliparous Pregnant Women

acronym: SPIRIT

summary:
Introduction: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to a chronic utero-placental hypoperfusion. Nowadays, there isn't a screening or diagnostic test in clinic for utero-placental vascularization deficiency. Since 2004, 3D Power Doppler angiography has been used for the evaluation of utero-placental vascularisation and three vascular indices have been calculated: the vascularisation index (VI), flow index (FI) and vascularisation-FI (VFI). A high intra and inter-observer reproducibility and its potential interest for placental function study were reported. The investigator's main hypothesis is that these 3DPD indices could provide predictive values for PE and/or IUGR occurrence much higher than those observed with the currents other markers.

Objectives: The main objective of this study is to determine differences in 3DPD indices at first trimester between pregnancies defined at their outcome as uncomplicated pregnancy, PE (mild and severe) and IUGR in nulliparous women.

Methods and analysis: This is a prospective study. The investigators expect to include 2200 women in 4 French centers: Centre Hospitalier Universitaire de Nancy, Paris-Port-Royal (Assistance Publique - Hôpitaux de Paris), Strasbourg and Belfort (Hôpital Nord Franche-Comté).

The nulliparous pregnant women will be recruited during their 1st trimester consultation for routine Down syndrome screening (11-13+6 gestation weeks). Especially for the study, the 3DPD and Uterine Artery Doppler (UAD) acquisition, which last less than 10 min, will be included in the current routine 11-13+6 gestation weeks ultrasound screening. Also, additional blood samples will be taken for biomarker analysis (PAPP-A and P1GF) and biological collection. Utero-placental vascularization indices (VI, FI, VFI) will be quantified using VOCAL® software. For each subgroup (uncomplicated pregnancy, PE and IUGR) mean values in 3DPD indices will be computed and compared using a pairwise t test with a Bonferroni correction p value adjustment.

ReferenceCitation: Bertholdt C, Hossu G, Banasiak C, Beaumont M, Morel O. First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women. BMJ Open. 2020 Oct 19;10(10):e037751. doi: 10.1136/bmjopen-2020-037751.

family: Bertholdt

full_name: Charline Bertholdt

given: Charline

family: Hossu

full_name: Gabriela Hossu

given: Gabriela

family: Banasiak

full_name: Claire Banasiak

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm


title: Intravitreous CytokinE Level in pAtient With retiNal Detachment

acronym: ICELAND

summary:
Photoreceptor apoptosis is the basis for permanent visual loss in a number of retinal disorders including age-related macular degeneration (AMD) and retinal detachment (RD). Thus, despite tremendous advances in vitreoretinal surgery and management of rhegmatogenous RD leading to a primary reattachment rate over 95%, some patients show poor visual recovery because of photoreceptor apoptosis.

Physiologically, microglial cells (resident macrophages) are present only in the inner retina. The subretinal space, located between the retinal pigment epithelium (RPE) and the photoreceptor outer segments (POS), is devoid of all mononuclear phagocytes and form a zone of immune privilege. In AMD, several studies showed a strong association between subretinal mononuclear phagocytes infiltration and advanced forms of AMD. Experimental work in mice suggest that this infiltration plays an important role in the pathogenesis of this condition by producing inflammatory cytokines.

RD-induced photoreceptor apoptosis might result from similar mechanisms. The aim of this study is to determine the cytokine profile in vitreous samples from patients with RD and to compare it with those from control patients with macular hole.

ReferenceCitation: Conart JB, Blot G, Augustin S, Millet-Puel G, Roubeix C, Beguier F, Charles-Messance H, Touhami S, Sahel JA, Berrod JP, Léveillard T, Guillonneau X, Delarasse C, Sennlaub F. Insulin inhibits inflammation-induced cone death in retinal detachment. J Neuroinflammation. 2020 Nov 26;17(1):358. doi: 10.1186/s12974-020-02039-1.

family: Conart

full_name: Jean-Baptiste Conart

given: Jean-Baptiste

family: Blot

full_name: Guillaume Blot

given: Guillaume

family: Augustin

full_name: Sébastien Augustin

family: Millet-Puel

full_name: Géraldine Millet-Puel

given: Géraldine

family: Roubeix

full_name: Christophe Roubeix

given: Christophe

family: Beguier

full_name: Fanny Beguier

given: Fanny

family: Charles-Messance

full_name: Hugo Charles-Messance

given: Hugo

family: Touhami

full_name: Sara Touhami

given: Sara

family: Sahel

full_name: José-Alain Sahel

given: José-Alain

family: Berrod

full_name: Jean-Paul Berrod

given: Jean-Paul

family: Léveillard

full_name: Thierry Léveillard

given: Thierry

family: Guillonneau

full_name: Xavier Guillonneau

given: Xavier

family: Delarasse

full_name: Cécile Delarasse

given: Cécile

family: Sennlaub

full_name: Florian Sennlaub

given: Florian

journal_name: Journal of Neuroinflammation

evidence: oa repository (via page says license)

repository_normalized: Research Square

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm


type: Registry Identifier

title: Intraoperative Monitoring (Parathormone Values and Continuous Neuromonitoring) to Predict Postoperative Complications After Total Thyroidectomy

acronym: PARACAL

summary: The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.


title: Visual Maturation in Prematurely Born Infants According to Factors Influencing Its Development. Premavision Follow-up at 18 Months Corrected Age, 4 and 7 Years of Age.

acronym: PrmvsionSuiv

summary:
This study aim at following a cohort of prematurely born infants at 18 months corrected age, 4 and 7 years of age. This cohort had an evaluation of visual maturation at term equivalent age (TEA) with factors associated with impaired visual maturation. (PREMAVISION-CLinicalTrials.gov ID: NCT02890251).

In this follow-up study, prematurely born infants vision will be compared to term born infants matched for postnatal age.

status: Terminated


title: Study of Gut Microbiota in Crohn's Disease Patients Suffering From Spondylarthritis

acronym: FLORACROHN

summary:
The FLORACROHN project aims to compare gut microbiota of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA).

3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA.

Fecal microbiota will be determined by 16SRNA gene sequencing.


title: VECU EMOTIONNEL CHEZ LES PATIENTES SOUFFRANT DE CRISES NON EPILEPTIQUES PSYCHOGENES : ETUDE EN IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE-ETUDE EMOCRISES

acronym: EMOCRISES

summary:
Currently, hypothetical models of understanding Psychogenic Non-epileptic Seizures (PNES) involve emotional dysregulation.

The hypothesis of a disorder of emotional experience is mainly based on behavioral data and disturbance of autonomic responses in response to images in emotional content (Mignot et al 2015, in submission; Bakvis et al 2013). Various imaging studies have identified brain structures belonging to the limbic system in particular that seem functionally impaired in this population. These functional connectivity abnormalities are correlated with dissociation scores in PNES patients (Van der Kruijs et al 2012 and 2014).

Investigators propose to specifically study the brain activity of PNES patients during tasks emotional content to identify the mechanisms involved in this emotional dysregulation. This work is essential to understanding the mechanisms and the development of new therapeutic strategies


title: Recurrence of Suicide Attempt in Adolescents Lost to Contact Early by Clinicians : The 10-years REPEATERS Cohort of French Adolescents

summary: Losing contact with adult suicide attempters in the year after the suicide attempt (SA) increases the risk of recurrence. The situation with adolescents is unknown. Investigators aimed to determine whether being lost to contact early (LCE) by clinicians is a risk factor of longterm SA recurrence among adolescents and the associated factors.

ReferenceCitation: Ligier F, Guillemin F, Angot C, Bourion S, Kabuth B. Recurrence of suicide attempt in adolescents lost to contact early by clinicians: The 10-year REPEATERS cohort of French adolescents. J Adolesc. 2015 Aug;43:111-8. doi: 10.1016/j.adolescence.2015.05.011. Epub 2015 Jun 12. Erratum in: J Adolesc. 2017 Jan;54:135-136.

ipd_sharing_description: open to partnership


title: Développement Méthodologique de l'Imagerie Par Résonance Magnétique (IRM)

acronym: METHODO

summary: The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.


title: Development of the General Scale Observance for Chronic Diseases (EGOMAC)

acronym: EGOMAC

summary:
The main objective is to assess the measurement characteristics (validity, reproducibility) and the invariance of EGOMAC scale in a population of consultants in diabetology, cardiology and rheumatology hospital and liberal and hospital oncology and Infectious disease, by following the evolution of patient compliance at D0 and D15.

The second objective is to assess the sensitivity to change of scale EGOMAC following developments compliance 3 months.


title: Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse

acronym: STAMP

summary:
Mitral valve prolapse (MVP) is a frequent affection of the mitral valve or its sub-valvular apparatus with a prevalence of 2-3% in the general population. This valvular disease is generally considered as benign, but may at term evolve toward mitral valve regurgitation of various severity and/or arrhythmia.

Mitral valve prolapse is routinely diagnosed using transthoracic echocardiography and only patients with significant mitral regurgitation will undergo subsequent examination (24-hour external loop recording, exercise ECG, cardiac MRI) and a close follow-up.

External loop recording and exercise ECG have an interest in the identification of patients presenting with arrhythmic complications, such as premature ventricular contractions, and in the global evaluation of hemodynamic consequences of the mitral regurgitation.

More recently, detection of myocardial fibrosis among patients with MVP and severe ventricular arrhythmia has been identified. Fibrosis could evolve independently of the valvular regurgitation's severity and could be a substrate (myocardial scar) leading to ventricular arrhythmia. However, no study has specifically characterized myocardial lesions among patients with MVP and none, or not significant, mitral regurgitation. Using cardiac magnetic resonance imaging (MRI), gold standard technique in myocardial imaging and characterization, and echocardiography, particularly speckle-tracking imaging, identification of static (fibrosis) and/or dynamic (ventricular systolic deformation patterns using speckle-tracking strain) myocardial lesions.

Identification of patients with impaired deformation patterns, fibrosis or with premature ventricular contractions may isolate a sub-group of patients with a higher risk of severe ventricular arrhythmia for whom a closer follow-up could be justified.

ReferenceCitation: Basso C, Perazzolo Marra M, Rizzo S, De Lazzari M, Giorgi B, Cipriani A, Frigo AC, Rigato I, Migliore F, Pilichou K, Bertaglia E, Cacciavillani L, Bauce B, Corrado D, Thiene G, Iliceto S. Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death. Circulation. 2015 Aug 18;132(7):556-66. doi: 10.1161/CIRCULATIONAHA.115.016291. Epub 2015 Jul 9.

ReferenceCitation: Huttin O, Pierre S, Venner C, Voilliot D, Sellal JM, Aliot E, Sadoul N, Juillière Y, Selton-Suty C. Interactions between mitral valve and left ventricle analysed by 2D speckle tracking in patients with mitral valve prolapse: one more piece to the puzzle. Eur Heart J Cardiovasc Imaging. 2017 Mar 1;18(3):323-331. doi: 10.1093/ehjci/jew075.

location_facility: Nancy University Hospital, Department of Cardiology


title: Expression of Ku70/XRCC6 and Others NHEJ Components in Waldenström's Macroglobulinemia in Comparison With Others B-cell Lymphoproliferative Disorders and Normal B Cells.

acronym: WAL-KU

summary:
Waldenström's macroglobulinemia is a rare disease whose pathophysiology remains at present poorly understood, although a recurrent mutation (L265P MYD88) has recently been described. Unlike other lymphoproliferative disorders, there is a defect in isotype switching, mechanism involving AID and NHEJ complex. Using a two-dimensional electrophoresis technology, our group showed that MW had a specific proteomic profile, and one of the differentially expressed proteins is Ku70 (encoded by XRCC6 belonging to NHEJ complex) .

The investigators purpose to explore the mechanisms of underexpression of Ku70/XRCC6 (genetic or epigenetic modification) in comparison with other lymphoid malignancies and normal B cells.

intervention_type: Biological


title: Use of a New ElectroCardioGraph to Create an ECG Database in 3T MRI With Healthy Heart and Several Kind of Cardiac Disease in Order to Let go of Artifacts.

summary: The aim is to create a database including recordings of ECG data recorded in an MRI acquisition

location_facility: Centre Hospitalier Universitaire de Nancy


title: Safety and Clinical Performance of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Abdominal Wall Reconstruction: an Observational Prospective Study.

summary:
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS membrane used in abdominal wall reconstruction including, but not limited to, ventral hernia repair and stoma closure, and to identify emerging risks in comparison to the clinical data related to other types of fixation material.

The present study will be a prospective multicentric non-randomized and noncontrolled trial involving 112 patients followed for 24 months. The study will be conducted in France in 3 investigational centres.

lead_sponsor: Meccellis Biotech

location_facility: CHU Montpellier, Hôpital Saint-Eloi, Pôle digestif, Service de Chirurgie Digestive B et Transplantation

location_facility: CHU Caen Normandie, Service de Chirurgie Digestive

location_facility: Groupe Hospitalier La Rochelle - Ré - Aunis

lead_sponsor_type: industriel


title: Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events on a Prospective Cohort of Subjects Aged 65 Years

acronym: PROOF

summary:
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity.

Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population.

This PROOF study was hence designed to evaluate ANS activity levels among a healthy retired population, but should these levels decline overtime, to use this as a predictor of cardiovascular and cerebrovascular events, taking into account established cardiovascular risk factors.

ReferenceCitation: Roche F, Gaspoz JM, Da Costa A, Isaaz K, Duverney D, Pichot V, Costes F, Lacour JR, Barthélémy JC. Frequent and prolonged asymptomatic episodes of paroxysmal atrial fibrillation revealed by automatic long-term event recorders in patients with a negative 24-hour Holter. Pacing Clin Electrophysiol. 2002 Nov;25(11):1587-93.

ReferenceCitation: Pichot V, Buffière S, Gaspoz JM, Costes F, Molliex S, Duverney D, Roche F, Barthélémy JC. Wavelet transform of heart rate variability to assess autonomic nervous system activity does not predict arousal from general anesthesia. Can J Anaesth. 2001 Oct;48(9):859-63.

ReferenceCitation: Barthélémy JC, Pichot V, Dauphinot V, Celle S, Laurent B, Garcin A, Maudoux D, Kerleroux J, Lacour JR, Kossovsky M, Gaspoz JM, Roche F. Autonomic nervous system activity and decline as prognostic indicators of cardiovascular and cerebrovascular events: the 'PROOF' Study. Study design and population sample. Associations with sleep-related breathing disorders: the 'SYNAPSE' Study. Neuroepidemiology. 2007;29(1-2):18-28.

ReferenceCitation: Gosse P, Roche F, Dauphinot V, Maudoux D, Pichot V, Barthelemy JC. Components of arterial stiffness in a population of 65-year-old subjects: PROOF study. J Hypertens. 2008 Jun;26(6):1138-46. doi: 10.1097/HJH.0b013e3282fa142b.

family: Gosse

full_name: Philippe Gosse

family: Roche

full_name: Frederic Roche

given: Frederic

family: Dauphinot

full_name: Virginie Dauphinot

given: Virginie

family: Maudoux

full_name: Delphine Maudoux

given: Delphine

family: Pichot

full_name: Vincent Pichot

given: Vincent

family: Barthelemy

full_name: Jean Claude Barthelemy

given: Jean Claude

journal_name: Journal of Hypertension

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

title: Components of arterial stiffness in a population of 65-year-old subjects: PROOF study

ReferenceCitation: Rouch I, Anterion CT, Dauphinot V, Kerleroux J, Roche F, Barthelemy JC, Laurent B. Cognitive complaints, neuropsychological performance and affective disorders in elderly community residents. Disabil Rehabil. 2008;30(23):1794-802. doi: 10.1080/09638280701667825.

family: Rouch

full_name: I. Rouch

given: I.

family: Anterion

full_name: C. Thomas Anterion

given: C. Thomas

full_name: V. Dauphinot

given: V.

family: Kerleroux

full_name: J. Kerleroux

given: J.

full_name: F. Roche

given: F.

full_name: J C. Barthelemy

given: J C.

family: Laurent

full_name: B. Laurent

given: B.

journal_name: Disability and Rehabilitation

publisher: Informa UK Limited

publisher_dissemination: Informa

publisher_group: Informa

publisher_normalized: Informa

title: Cognitive complaints, neuropsychological performance and affective disorders in elderly community residents

ReferenceCitation: Hupin D, Raffin J, Barth N, Berger M, Garet M, Stampone K, Celle S, Pichot V, Bongue B, Barthelemy JC, Roche F. Even a Previous Light-Active Physical Activity at Work Still Reduces Late Myocardial Infarction and Stroke in Retired Adults Aged>65 Years by 32%: The PROOF Cohort Study. Front Public Health. 2019 Mar 19;7:51. doi: 10.3389/fpubh.2019.00051. eCollection 2019.

family: Hupin

full_name: David Hupin

given: David

family: Raffin

full_name: Jérémy Raffin

given: Jérémy

family: Barth

full_name: Nathalie Barth

given: Nathalie

family: Berger

full_name: Mathieu Berger

given: Mathieu

family: Garet

full_name: Martin Garet

ReferenceCitation: Sforza E, Millasseau S, Hupin D, Barthélémy JC, Roche F. Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study. Sleep Breath. 2019 Mar;23(1):201-208. doi: 10.1007/s11325-018-1683-x. Epub 2018 Jun 26.

ReferenceCitation: Celle S, Boutet C, Annweiler C, Barthélémy JC, Roche F. Sleep apnoea in the asymptomatic elderly: a real issue for the brain? Eur Respir J. 2018 Jun 14;51(6). pii: 1702450. doi: 10.1183/13993003.02450-2017. Print 2018 Jun.

title: Sleep apnoea in the asymptomatic elderly: a real issue for the brain?

ReferenceCitation: Monneret D, Barthélémy JC, Hupin D, Maudoux D, Celle S, Sforza E, Roche F. Serum lipid profile, sleep-disordered breathing and blood pressure in the elderly: a 10-year follow-up of the PROOF-SYNAPSE cohort. Sleep Med. 2017 Nov;39:14-22. doi: 10.1016/j.sleep.2017.07.028. Epub 2017 Sep 18.

ReferenceCitation: Saint Martin M, Labeix P, Garet M, Thomas T, Barthélémy JC, Collet P, Roche F, Sforza E. Does Subjective Sleep Affect Bone Mineral Density in Older People with Minimal Health Disorders? The PROOF Cohort. J Clin Sleep Med. 2016 Nov 15;12(11):1461-1469.

ReferenceCitation: Sforza E, Saint Martin M, Thomas T, Collet P, Garet M, Barthélémy JC, Roche F. Risk factors of osteoporosis in healthy elderly with unrecognized obstructive sleep apnea: role of physical activity. Sleep Med. 2016 Jun;22:25-32. doi: 10.1016/j.sleep.2016.04.010. Epub 2016 Jun 7.

ReferenceCitation: Sforza E, Saint Martin M, Barthélémy JC, Roche F. Mood disorders in healthy elderly with obstructive sleep apnea: a gender effect. Sleep Med. 2016 Mar;19:57-62. doi: 10.1016/j.sleep.2015.11.007. Epub 2015 Nov 25.

title: Mood disorders in healthy elderly with obstructive sleep apnea: a gender effect

ReferenceCitation: Boutet C, Vassal F, Celle S, Schneider FC, Barthélémy JC, Laurent B, Barral FG, Roche F. Incidental findings on brain magnetic resonance imaging in the elderly:the PROOF study. Brain Imaging Behav. 2017 Feb;11(1):293-299. doi: 10.1007/s11682-016-9519-4.

title: Incidental findings on brain magnetic resonance imaging in the elderly:the PROOF study

ReferenceCitation: Sforza E, Celle S, Saint-Martin M, Barthélémy JC, Roche F. Hippocampus volume and subjective sleepiness in older people with sleep-disordered breathing: a preliminary report. J Sleep Res. 2016 Apr;25(2):190-3. doi: 10.1111/jsr.12367. Epub 2015 Dec 14.

name: Service de Physiologie Clinique et de l'Exercice (Pôle Hospitalier NOL); Faculté de Médecine Jacques Lisfranc; CHU Nord; Université Jean Monnet; Saint-Etienne France

ReferenceCitation: Sforza E, Pichot V, Martin MS, Barthélémy JC, Roche F. Prevalence and determinants of subjective sleepiness in healthy elderly with unrecognized obstructive sleep apnea. Sleep Med. 2015 Aug;16(8):981-6. doi: 10.1016/j.sleep.2015.03.010. Epub 2015 Apr 15.

ReferenceCitation: Sforza E, Sabri M, DaCosta A, Isaaz K, Barthélémy JC, Roche F. Echocardiographic Findings in Healthy Elderly People with Unrecognized Sleep Disordered Breathing. J Clin Sleep Med. 2015 Sep 15;11(9):975-80. doi: 10.5664/jcsm.5006.

name: Service de Physiologie Clinique et de l'Exercice (Pole Hospitalier NOL), CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France

name: Service de Cardiologie CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France

publisher: American Academy of Sleep Medicine (AASM)

publisher_dissemination: American Academy of Sleep Medicine (AASM)

publisher_group: American Academy of Sleep Medicine (AASM)

publisher_normalized: American Academy of Sleep Medicine (AASM)

title: Echocardiographic Findings in Healthy Elderly People with Unrecognized Sleep Disordered Breathing

ReferenceCitation: Saint Martin M, Roche F, Thomas-Anterion C, Barthélémy JC, Sforza E; PROgnostic OF cardiovascular and cerebrovascular events study group. Eight-year parallel change in baroreflex sensitivity and memory function in a sample of healthy older adults. J Am Geriatr Soc. 2015 Feb;63(2):270-5. doi: 10.1111/jgs.13252. Epub 2015 Feb 2.

name: Département de Physiologie Clinique et de l'exercice; Pôle Neuro-Ostéo Locomoteur; Centre Hospitalo-Universitaire; Faculté de Mèdecine de Saint-Etienne; Université Jean Moulin; Saint-Etienne France

name: pôle de Recherche et d'Enseignement Supérieur; Université de Lyon; Lyon France

name: Laboratoire d'Etude des Mécanismes Cognitifs; University of Lyon 2; Lyon France

name: the PROgnostic OF cardiovascular and cerebrovascular events study group

journal_name: Journal of the American Geriatrics Society

title: Eight-Year Parallel Change in Baroreflex Sensitivity and Memory Function in a Sample of Healthy Older Adults

ReferenceCitation: Martin MS, Sforza E, Roche F, Barthélémy JC, Thomas-Anterion C; PROOF study group. Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort. Sleep. 2015 Feb 1;38(2):179-87. doi: 10.5665/sleep.4392.

name: Department of Clinical Physiology and Exercise, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, UJM and PRES University of Lyon, Saint-Etienne, France

name: EMC Laboratory, EA 3880, University of Lyon 2, Lyon, France

title: Sleep Breathing Disorders and Cognitive Function in the Elderly: An 8-Year Follow-up Study. The Proof-Synapse Cohort

ReferenceCitation: Sforza E, Saint Martin M, Barthelemy JC, Roche F. Association of self-reported sleep and hypertension in non-insomniac elderly subjects. J Clin Sleep Med. 2014 Sep 15;10(9):965-71. doi: 10.5664/jcsm.4026.

name: Service de Physiologie Clinique et de l'Exercice, CHU Nord, Saint-Etienne, Faculté de Médecine Jacques Lisfranc, PRES de Lyon 42023, Université Jean Monnet, Saint-Etienne, France

title: Association of Self-Reported Sleep and Hypertension in Non-Insomniac Elderly Subjects

ReferenceCitation: Saint Martin M, Sforza E, Thomas-Anterion C, Barthélémy JC, Roche F; PROOF Study Group. Baroreflex sensitivity, vascular risk factors, and cognitive function in a healthy elderly population: the PROOF cohort. J Am Geriatr Soc. 2013 Dec;61(12):2096-2102. doi: 10.1111/jgs.12548. Epub 2013 Nov 26.

name: Département de Physiologie Clinique et de l'Exercice Pôle Neuro‐OstéoLocomoteur Centre Hospitalo‐UniversitaireSaint‐Étienne France

name: Faculté de Médicine de Saint‐Etienne Université Jean Moulin Saint‐Étienne France

name: Pôle de Recherche et d'Enseignement Supérieur Université de LyonLyon France

name: Laboratoire des Mécanismes Cognitifs Université de Lyon 2 Lyon France

title: Baroreflex Sensitivity, Vascular Risk Factors, and Cognitive Function in a Healthy Elderly Population: The PROOF Cohort

ReferenceCitation: Sforza E, Thomas T, Barthélémy JC, Collet P, Roche F. Obstructive sleep apnea is associated with preserved bone mineral density in healthy elderly subjects. Sleep. 2013 Oct 1;36(10):1509-15. doi: 10.5665/sleep.3046.

name: Service de Physiologie Clinique et de l'Exercice, CHU Nord, Saint-Etienne, Faculté de Médecine Jacques Lisfranc, PRES de Lyon 42023,Université Jean Monnet, Saint-Etienne, France

name: Service de Rhumatologie, CHU Saint-Etienne, Faculté de Médecine Jacques Lisfranc, Inserm U1059 LBTO, UJM, PRES de Lyon, Université Jean Monnet, Saint-Etienne, France

title: Obstructive Sleep Apnea is Associated with Preserved Bone Mineral Density in Healthy Elderly Subjects

ReferenceCitation: Martin MS, Sforza E, Barthélémy JC, Thomas-Anterion C, Roche F. Sleep perception in non-insomniac healthy elderly: a 3-year longitudinal study. Rejuvenation Res. 2014 Feb;17(1):11-8. doi: 10.1089/rej.2013.1457.

name: Department of Clinical Physiology and Exercise, Pole NOL, CHU, and Faculty of Medicine of Saint-Etienne, UJM and PRES University of Lyon, EA 4607 SNA-EPIS, Saint-Étienne, France.

name: EMC laboratory, EA 3880, University of Lyon 2, Lyon, France.

title: Sleep Perception in Non-Insomniac Healthy Elderly: A 3-Year Longitudinal Study

ReferenceCitation: Chouchou F, Pichot V, Pépin JL, Tamisier R, Celle S, Maudoux D, Garcin A, Lévy P, Barthélémy JC, Roche F; PROOF Study Group. Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study. Eur Heart J. 2013 Jul;34(28):2122-31, 2131a. doi: 10.1093/eurheartj/eht208. Epub 2013 Jun 11.

ReferenceCitation: Degache F, Sforza E, Dauphinot V, Celle S, Garcin A, Collet P, Pichot V, Barthélémy JC, Roche F; PROOF Study Group. Relation of central fat mass to obstructive sleep apnea in the elderly. Sleep. 2013 Apr 1;36(4):501-7. doi: 10.5665/sleep.2532.

name: Health Research Unit, High School of Health, University of Applied Sciences Western Switzerland, Lausanne, Switzerland

name: Service de Physiologie Clinique et de l'Exercice, CHU Nord, Saint-Etienne, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France; PRES Université de Lyon, France

name: Neurology Unit D, Memory Research Center, Lyon University Hospital, France

name: DIRC, CHU de Saint-Etienne, Saint-Etienne, France

name: Service de Rhumatologie, CHU Saint-Etienne, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France

title: Relation of Central Fat Mass to Obstructive Sleep Apnea in the Elderly

ReferenceCitation: Dauphinot V, Rouch I, Kossovsky MP, Pichot V, Dorey JM, Krolak-Salmon P, Laurent B, Roche F, Barthélémy JC. Depressive symptoms and autonomic nervous system dysfunction in an elderly population-based study: the PROOF study. J Affect Disord. 2012 Dec 20;143(1-3):153-9. doi: 10.1016/j.jad.2012.05.045. Epub 2012 Aug 19.

title: Depressive symptoms and autonomic nervous system dysfunction in an elderly population-based study: The PROOF study

ReferenceCitation: Sforza E, Gauthier M, Crawford-Achour E, Pichot V, Maudoux D, Barthélémy JC, Roche F. A 3-year longitudinal study of sleep disordered breathing in the elderly. Eur Respir J. 2012 Sep;40(3):665-72. doi: 10.1183/09031936.00133011. Epub 2012 Mar 9.

title: A 3-year longitudinal study of sleep disordered breathing in the elderly

ReferenceCitation: Tønnesen P, Lauri H, Perfekt R, Mann K, Batra A. Efficacy of a nicotine mouth spray in smoking cessation: a randomised, double-blind trial. Eur Respir J. 2012 Sep;40(3):548-54. doi: 10.1183/09031936.00155811. Epub 2012 Feb 9.

title: Efficacy of a nicotine mouth spray in smoking cessation: a randomised, double-blind trial

ReferenceCitation: Assoumou HG, Bertholon F, Barthélémy JC, Pichot V, Celle S, Gosse P, Gaspoz JM, Roche F. Alteration of baroreflex sensitivity in the elderly: the relationship with metabolic syndrome components. Int J Cardiol. 2012 Mar 8;155(2):333-5. doi: 10.1016/j.ijcard.2011.12.050. Epub 2012 Jan 10.

title: Alteration of baroreflex sensitivity in the elderly: The relationship with metabolic syndrome components

ReferenceCitation: Sforza E, Chouchou F, Pichot V, Barthélémy JC, Roche F. Heart rate increment in the diagnosis of obstructive sleep apnoea in an older population. Sleep Med. 2012 Jan;13(1):21-8. doi: 10.1016/j.sleep.2011.04.011. Epub 2011 Nov 21.

title: Heart rate increment in the diagnosis of obstructive sleep apnoea in an older population

ReferenceCitation: Dauphinot V, Barthélémy JC, Pichot V, Celle S, Sforza E, Achour-Crawford E, Gosse P, Roche F. Autonomic activation during sleep and new-onset ambulatory hypertension in the elderly. Int J Cardiol. 2012 Feb 23;155(1):155-9. doi: 10.1016/j.ijcard.2011.10.097. Epub 2011 Nov 9.

title: Autonomic activation during sleep and new-onset ambulatory hypertension in the elderly

ReferenceCitation: Ntougou Assoumou HG, Pichot V, Barthelemy JC, Dauphinot V, Celle S, Collet P, Gaspoz JM, Roche F. Obesity-related autonomic nervous system disorders are best associated with body fat mass index, a new indicator. Int J Cardiol. 2011 Nov 17;153(1):111-3. doi: 10.1016/j.ijcard.2011.09.031. Epub 2011 Oct 2.

ReferenceCitation: Chouchou F, Sforza E, Celle S, Pichot V, Maudoux D, Garcin A, Barthélémy JC, Roche F; PROOF Study Group. Pulse transit time in screening sleep disordered breathing in an elderly population: the PROOF-SYNAPSE study. Sleep. 2011 Aug 1;34(8):1051-9. doi: 10.5665/SLEEP.1160.

name: INSERM, U1028; CNRS, UMR5292; Centre de Recherche en Neurosciences de Lyon, Integration centrale de la douleur chez l'Homme, Universite Claude Bernard, Lyon, F-69000, France

name: Service de Physiologie Clinique, Pole NOL, CHU Nord, EA 4607 SNA-EPIS, Universite Jean Monnet, PRES de Lyon, Saint-Etienne F-42023, France

title: Pulse Transit Time in Screening Sleep Disordered Breathing In An Elderly Population: The PROOF-SYNAPSE Study

ReferenceCitation: Castro-Lionard K, Thomas-Antérion C, Crawford-Achour E, Rouch I, Trombert-Paviot B, Barthélémy JC, Laurent B, Roche F, Gonthier R. Can maintaining cognitive function at 65 years old predict successful ageing 6 years later? The PROOF study. Age Ageing. 2011 Mar;40(2):259-65. doi: 10.1093/ageing/afq174. Epub 2011 Jan 20.

name: Department of Geriatrics, University Hospital of Saint-Etienne, 42055 Saint Etienne Cedex 2, France

name: PRES Lyon – Neurology Department, Resources and Research Memory Centre, University Medical Hospital of Saint-Etienne, Saint Etienne, France

name: Department of Public Health and Medical Informatics, University Hospital of Saint-Etienne, Saint Etienne, France

name: PRES Lyon – SNA-EPIS Research Unit, Exercise and Clinical Physiology Laboratory, University Hospital and Jean Monnet University, Saint Etienne, France

title: Can maintaining cognitive function at 65 years old predict successful ageing 6 years later? The PROOF study

ReferenceCitation: Sforza E, Chouchou F, Collet P, Pichot V, Barthélémy JC, Roche F. Sex differences in obstructive sleep apnoea in an elderly French population. Eur Respir J. 2011 May;37(5):1137-43. doi: 10.1183/09031936.00043210. Epub 2010 Sep 3.

title: Sex differences in obstructive sleep apnoea in an elderly French population

lead_sponsor: Centre Hospitalier Universitaire de Saint Etienne


title: Clinical Evaluation of Morbidity and Efficacy of Posterior IVS (Infracoccygeal Sacropexy), in Comparison to the Standard Sacrospinous Suspension in the Surgical Treatment of Vaginal Vault Prolapse by the Vaginal Route.

summary:
Hypothesis / aims of study The aim of this multicentre study is to evaluate anatomical and functional results of an innovative posterior tape in vaginal prolapse repair by vaginal route, in comparison to the sacrospinous suspension.

Study design, materials and methods This study involves 5 centres in French Public Hospital. Patients will be randomly allocated to be operated by a sacrospinous suspension or by an posterior IVSTM (Tyco Healthcare, France). Prolapse severity will be evaluated using the POP-Q system. In order to evaluate the patient's quality of life, the validated PFDI and the PFIQ questionnaires will be used preoperatively and during follow-up, as well as a validated questionnaire on sexual problems. The difference on early post-operative pain should be 30% (40% for the sacrospinous suspension and 10% for the posterior IVS). Then the estimated number of patient is 40 in each arm.

lead_sponsor: Centre Hospitalier Universitaire de Nīmes


title: Evaluation of a Tdap-IPV Vaccination Remedial Strategy on Vaccination Coverage in Patients 65 Years of Age or Older in the French County of Sarthe

acronym: HOSPIVAC

summary:
In France, vaccination coverage is insufficient (in 2002, 71.2% coverage for tetanus, 41.9% for poliomyelitis and 33.7% for diphteria). These numbers decrease significantly with age: coverage for people aged over 65 was 60.5%, 13.3% and 10.5% for tetanus, poliomyelitis and diphteria coverage respectively.

The primary objective of this study is to evaluate the impact of a hospital based vaccination remedial strategy for Tdap-IPV (tetanus, diphteria, pertussis and polio vaccine) in patients 65 years of age or older.

Secondary objectives are to measure the vaccination coverage of patients aged 65 years or older hospitalised in a medical ward in our hospital, to evaluate their knowledge of their vaccination coverage, and to evaluate the socio-demographic factors associated with vaccination coverage.

primary_purpose: Treatment

lead_sponsor: Centre Hospitalier le Mans


title: Neuropsychological Assessment of Remediation for Cognitive Impairment in Schizophrénie

acronym: NARCIS

summary: This study evaluates the effect of a cognitive remediation program designed for patients suffering from a schizophrenia spectrum disorder ; on neurocognitive, social cognitive and metacognitive functions. In this double-blind (patients, outcomes assessors) controlled randomized trial the investigators compare patients receiving Ecological Cognitive training program for schizophrenia spectrum disorder [ECo-Sz] to patients benefiting from recovery-oriented therapy [ThOR]. Patients are treated for two months and monitored for four months.

lead_sponsor: Centre hospitalier de Ville-Evrard, France

location_facility:
Ch Ville Evrard
URC Ville Evrard


title: Lung Cancer Screening by Low Dose CT Scan in a French Department (DEP KP80)

summary:
Lung cancer is the leading cause of cancer death worldwide. The aims of this study were to assess the feasibility and effectiveness of a lung cancer screening pilot program with LD CT scan in a French department (Somme).

DEP KP80 was a single-arm, prospective study started in May 2016. The inclusion criteria were those of the National Lung Screening Trial. An annual LD CT scan was scheduled and 2 rounds were planned. Smoking cessation was encouraged as part of the protocol.

Subjects were selected by General Practitioner or Pneumologist who checked the inclusion criteria and prescribed the CT scan.

lead_sponsor: Centre Hospitalier d'Abbeville


title: National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis

acronym: ALTITUDES

summary: The purpose of this study is to constitute the French largest Aggressive fibromatosis cohort.

lead_sponsor: Centre Oscar Lambret

location_facility: Institut de Cancérologie de l'Ouest - Site René Gauducheau

location_facility: Institut Curie Département Oncologie Pédiatrique

location_facility: Institut de Cancérologie Lucien Neuwirth

location_facility: Hôpital la Timone Service Oncologie Médicale

location_facility: Institut de Cancérologie de l'Ouest - Paul Papin

location_facility: Institut Curie Département Oncologie Médicale

location_facility: Hôpital la Timone Enfants Service Oncologie Pédiatrique


title: Evaluation of Changes in Weight, Sleep, and Other Psycho-behavioural Parameters During Covid-19 Confinement in Subjects Monitored by the RNPC Network

acronym: CO-RNPC

summary:
During confinement, food intake can become compulsive, physical activity is significantly reduced, sleep is altered with exacerbated anxiety and stress levels and increased family violence. In some at-risk patients, mental health may even deteriorate. The temptation is great for all to take refuge in food or in front of screens. The main elements that can impact weight changes during this period of confinement are stress and anxiety, lack of physical activity, changes in eating habits, sleep disturbance and alcohol consumption.

The investigators wish to study the impact of confinement on pre-post confinement weight loss kinetics in adults included in weight reduction programs (RNPC).

lead_sponsor: University Hospital, Grenoble


title: Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 in Bordeaux Urban Area, June 2011: Evaluation of Diagnostic, Prognostic and Pathophysiological Data

acronym: SHU O104 CUB

summary:
The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).

At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin.

Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS.

The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.

lead_sponsor: University Hospital, Bordeaux

location_facility: Service de Néphrologie, transplantation dialyse - Hôpital Pellegrin


title: L'Impact de la Raideur Articulaire Pelvienne Sur la Peur de Chuter du Sujet âgé hospitalisé ou en Institution.

acronym: RAAPC

summary:
/ evaluation of the fear of falling using an FES-I questionnaire, distribution of subjects according to the score into 3 groups (16-19: little concerned by the fear of falling, 20-27 moderately concerned, 28-64 very concerned by fear of falling)
/ evaluation of lumbar articular mobility by the schober index, coxofemoral by hip goniometry in flexion and extension (no evaluation of other amplitudes because lack of abduction / abduction / external and internal rotation of the hip remain functional in walking and the balance)

ReferenceCitation: Tinetti ME, Powell L. Fear of falling and low self-efficacy: a case of dependence in elderly persons. J Gerontol. 1993 Sep;48 Spec No:35-8.

ReferenceCitation: Kendrick D, Kumar A, Carpenter H, Zijlstra GA, Skelton DA, Cook JR, Stevens Z, Belcher CM, Haworth D, Gawler SJ, Gage H, Masud T, Bowling A, Pearl M, Morris RW, Iliffe S, Delbaere K. Exercise for reducing fear of falling in older people living in the community. Cochrane Database Syst Rev. 2014 Nov 28;(11):CD009848. doi: 10.1002/14651858.CD009848.pub2. Review.

ReferenceCitation: Delbaere K, Close JC, Mikolaizak AS, Sachdev PS, Brodaty H, Lord SR. The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study. Age Ageing. 2010 Mar;39(2):210-6. doi: 10.1093/ageing/afp225. Epub 2010 Jan 8.

lead_sponsor: Hopital of Melun


title: Development of Tools for Respiration and Circulation Studies and Exploration, Their Mutual Interactions and the Functions Involved in the Daily Life in Healthy Volunteers

acronym: MAPO-RCVQ

summary: This study is aimed to develop analysis methods and measurements tools for physiological variables : respiration, circulation and their mutual interactions and with the functions involved in the daily life in healthy volunteers (drinking, eating, sleeping, coughing...). The devices that are used are non invasive. The development of these tools needs to be validated on physiological signals obtained in healthy volunteers.

ReferenceCitation: Fiamma MN, Straus C, Thibault S, Wysocki M, Baconnier P, Similowski T. Effects of hypercapnia and hypocapnia on ventilatory variability and the chaotic dynamics of ventilatory flow in humans. Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1985-93. Epub 2007 Jan 11.

ReferenceCitation: Ben Lamine S, Calabrese P, Perrault H, Dinh TP, Eberhard A, Benchetrit G. Individual differences in respiratory sinus arrhythmia. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2305-12. Epub 2004 Jan 29.

ReferenceCitation: Eberhard A, Calabrese P, Baconnier P, Benchetrit G. Comparison between the respiratory inductance plethysmography signal derivative and the airflow signal. Adv Exp Med Biol. 2001;499:489-94.

ReferenceCitation: Emeriaud G, Eberhard A, Benchetrit G, Debillon T, Baconnier P. Calibration of respiratory inductance plethysmograph in preterm infants with different respiratory conditions. Pediatr Pulmonol. 2008 Nov;43(11):1135-1141. doi: 10.1002/ppul.20923.

ReferenceCitation: Fontecave-Jallon, Gumery P-Y, Calabrese P, Briot R, Baconnier P. A wearable technology revisited for cardio-respiratory functional exploration : Stroke volume estimation form respiratory inductive plethysmography. International journal of eHealth and Medical Communications, 4, 2013

location_facility:
University Hospital
TIMC - pavillon Taillefer - CHU


title: French Database of Left Atrial Appendage Closure

acronym: FLAAC

summary:
Patients with atrial fibrillation are exposed to a high risk of thrombus in the left atrium that can induce cerebral vascular events or systemic embolisms. This justifies the prescription of anticoagulant therapies in patients with high risk of thromboembolic event. Percutaneous left atrial appendage closure is a new interventional strategy for patients with high risk of cardiovascular events and a counter-indication for long term treatment with anticoagulant agents. However, only few data are available on effectiveness and prognosis of patients treated by this new interventional strategy.

This national database record per-procedure and follow-up data of patients treated by left atrial appendage closure.

This database is strictly observational.

Percutaneous left atrial appendage closure is performed only for the purpose of patient care. No specific intervention is performed specifically for the database. Neither left atrial appendage closure procedure nor patient follow up are modified by patient inclusion in the database.

ReferenceCitation: Teiger E, Thambo JB, Defaye P, Hermida JS, Abbey S, Klug D, Juliard JM, Spaulding C, Armero S, Champagnac D, Bhugaloo H, Ternacle J, Lellouche N, Audureau E, Le Corvoisier P; French national Left Atrial Appendage Closure registry (FLAAC) investigators. Left atrial appendage closure for stroke prevention in atrial fibrillation: Final report from the French left atrial appendage closure registry. Catheter Cardiovasc Interv. 2021 Oct;98(4):788-799. doi: 10.1002/ccd.29795. Epub 2021 May 29.

name: Department of Cardiology Henri Mondor University Hospital, AP‐HP  Creteil France

family: Teiger

full_name: Emmanuel Teiger

given: Emmanuel

name: Department of Pediatric and Congenital Cardiology University Hospital of Bordeaux  Pessac France

family: Thambo

full_name: Jean‐Benoit Thambo

given: Jean‐Benoit

name: Department of Rhythmology University Hospital of Grenoble‐Alpes  Grenoble France

family: Defaye

full_name: Pascal Defaye

given: Pascal

name: Department of Cardiac Arrhythmia Picardie University Hospital  Amiens France

family: Hermida

full_name: Jean‐Sylvain Hermida

given: Jean‐Sylvain

name: Interventional Cardiology Unit Hôpital Prive du Confluent  Nantes France

family: Abbey

full_name: Sélim Abbey

given: Sélim

name: Department of Electrophysiology Lille University Hospital  Lille France

family: Klug

full_name: Didier Klug

given: Didier

name: Département de Cardiologie Hôpital Bichat, Université Paris‐Diderot, Inserm U‐1148, AP‐HP  Paris France

family: Juliard

full_name: Jean‐Michel Juliard

given: Jean‐Michel

name: Department of Cardiology, European Hospital Georges Pompidou, AP‐HP Paris Descartes University, INSERM U 970, Sudden Cardiac Death Expert Center  Paris France

family: Spaulding

full_name: Christian Spaulding

given: Christian

name: Department of Cardiology Hôpital Européen  Marseille France

family: Armero

full_name: Sébastien Armero

given: Sébastien

name: Department of Cardiology Tonkin Clinic  Villeurbane France

family: Champagnac

full_name: Didier Champagnac

name: Inserm, CIC 1430 Henri Mondor University Hospital  Creteil France

family: Bhugaloo

full_name: Hamza Bhugaloo

given: Hamza

family: Ternacle

full_name: Julien Ternacle

given: Julien

family: Lellouche

full_name: Nicolas Lellouche

given: Nicolas

name: Public Health Department Hôpital Henri Mondor  Créteil France

name: U955‐IMRB, Equipe CEpiA, Inserm UPEC  Créteil France

family: Audureau

full_name: Etienne Audureau

given: Etienne

name: U955‐IMRB, Equipe 03, Inserm UPEC, Ecole Nationale Vétérinaire d'Alfort  Créteil France

family: Le Corvoisier

full_name: Philippe Le Corvoisier

given: Philippe

name: the French national Left Atrial Appendage Closure registry (FLAAC) investigators

journal_name: Catheterization and Cardiovascular Interventions

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

ReferenceCitation: Teiger E, Thambo JB, Defaye P, Hermida JS, Abbey S, Klug D, Juliard JM, Pasquie JL, Rioufol G, Lepillier A, Elbaz M, Horvilleur J, Brenot P, Pierre B, Le Corvoisier P; French National Left Atrial Appendage Closure Registry (FLAAC) Investigators. Percutaneous Left Atrial Appendage Closure Is a Reasonable Option for Patients With Atrial Fibrillation at High Risk for Cerebrovascular Events. Circ Cardiovasc Interv. 2018 Mar;11(3):e005841. doi: 10.1161/CIRCINTERVENTIONS.117.005841.

name: From the Interventional Cardiology Unit (E.T.) and Inserm, CIC 1430, U955 team 3 (P.L.C.), Henri Mondor Hospital, Creteil, France; Department of Pediatric and Congenital Cardiology, University Hospital of Bordeaux, Pessac, France (J.-B.T.); Department of Rhythmology, University Hospital of Grenoble-Alpes, France (P.D.); Department of Cardiac Arrhythmia, Picardie University Hospital, Amiens, France (J.-S.H.); Interventional Cardiology Unit, Hopital Prive du Confluent, Nantes, France (S.A.);...

full_name: Jean-Benoit Thambo

given: Jean-Benoit

full_name: Jean-Sylvain Hermida

given: Jean-Sylvain

name: on behalf of the French National Left Atrial Appendage Closure Registry (FLAAC) Investigators*

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria


title: Development of a Tool for the Self-assessment of Flare in Patients With Osteoarthritis of Lower Limbs

acronym: FLARE-OA

summary:
The need for a tool to measure flare in lower limb osteoarthritis (OA of the hip and knee) is justified by the opportunities for development of clinical trials targeting hip and knee OA long-term treatment (slow acting drug, disease modifying drug) and short-term treatment of symptoms. Such treatments are currently under development and will likely bring important changes in the treatment of patients. The development of a Flare-OA tool would be essential to capture the occurrence of flare, and to implement and adapt treatment strategies.

This project was elaborated with the aims to:

define the construct through development of a conceptual framework
use the conceptual framework to inform the development of a patient-reported outcome measure, Flare-OA tool, for people with OA
evaluate the psychometric properties of the new measure using the OMERACT (Outcome Measures in Rheumatology) filter 2.0 and Rasch measurement methods.

status: Enrolling by invitation

ReferenceCitation: Guillemin F, Ricatte C, Barcenilla-Wong A, Schoumacker A, Cross M, Alleyrat C, Buttel T, Cembalo M, Manseur H, Urban H, Fautrel B, Conaghan PG, Hawker G, Rutherford C, March L, Spitz E, Hunter DJ. Developing a Preliminary Definition and Domains of Flare in Knee and Hip Osteoarthritis (OA): Consensus Building of the Flare-in-OA OMERACT Group. J Rheumatol. 2019 Sep;46(9):1188-1191. doi: 10.3899/jrheum.181085. Epub 2019 May 15.

family: Guillemin

full_name: Francis Guillemin

given: Francis

family: Ricatte

full_name: Camille Ricatte

given: Camille

family: Barcenilla-Wong

full_name: Annica Barcenilla-Wong

given: Annica

family: Schoumacker

full_name: Amandine Schoumacker

given: Amandine

family: Cross

full_name: Marita Cross

given: Marita

family: Alleyrat

full_name: Camille Alleyrat

family: Buttel

full_name: Thomas Buttel

given: Thomas

family: Cembalo

full_name: Michel Cembalo

given: Michel

family: Manseur

full_name: Hakima Manseur

given: Hakima

family: Urban

full_name: Hema Urban

given: Hema

family: Fautrel

full_name: Bruno Fautrel

given: Bruno

family: Conaghan

full_name: Philip G. Conaghan

given: Philip G.

family: Hawker

full_name: Gillian Hawker

given: Gillian

family: Rutherford

full_name: Claudia Rutherford

given: Claudia

family: March

full_name: Lyn March

given: Lyn

family: Spitz

full_name: Elisabeth Spitz

given: Elisabeth

family: Hunter

full_name: David J. Hunter

given: David J.

journal_name: The Journal of Rheumatology

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: University of Leeds, The University of Sheffield, University of York - White Rose Research Online

version: acceptedVersion

publisher: The Journal of Rheumatology

publisher_dissemination: The Journal of Rheumatology

publisher_group: The Journal of Rheumatology

publisher_normalized: The Journal of Rheumatology

location_country: Canada Australia France

location_facility: Institute of Bone and Joint Research - University of Sydney


title: Allogeneic Hematopoietic Stem Cell Transplantation Evaluation in High Risk Myelodysplasia: an Observational Non-interventional Study Comparing Outcome of Patients Aged From 50 to 70 Years With or Without Donor

acronym: ONIalloMDS

summary: The purpose of this study is to compare outcome of high risk myelodysplasia patients aged from 50 to 70 years with or without HLA compatible (9 or 10 identities / 10) donor. High risk myelodysplasia includes IPSS intermediate 2 and high myelodysplasia and patients with sever thrombocytopenia. Patients are registered when they acquire risk factors.

lead_sponsor: Saint-Louis Hospital, Paris, France


summary: Tourette syndrome is rare. In France, about 3000 patients have a severe form of the disease. The aim of this study is to collect clinical characteristics in 200 patients with Tourette syndrome.

ReferenceCitation: Worbe Y, Mallet L, Golmard JL, Béhar C, Durif F, Jalenques I, Damier P, Derkinderen P, Pollak P, Anheim M, Broussolle E, Xie J, Mesnage V, Mondon K, Viallet F, Jedynak P, Ben Djebara M, Schüpbach M, Pelissolo A, Vidailhet M, Agid Y, Houeto JL, Hartmann A. Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS One. 2010 Sep 24;5(9):e12959. doi: 10.1371/journal.pone.0012959.

family: Worbe

full_name: Yulia Worbe

given: Yulia

family: Mallet

full_name: Luc Mallet

given: Luc

family: Golmard

full_name: Jean-Louis Golmard

given: Jean-Louis

family: Béhar

full_name: Cécile Béhar

given: Cécile

family: Durif

full_name: Franck Durif

given: Franck

family: Jalenques

full_name: Isabelle Jalenques

given: Isabelle

family: Damier

full_name: Philippe Damier

given: Philippe

family: Derkinderen

full_name: Pascal Derkinderen

given: Pascal

family: Pollak

full_name: Pierre Pollak

given: Pierre

family: Anheim

full_name: Mathieu Anheim

given: Mathieu

family: Broussolle

full_name: Emannuel Broussolle

given: Emannuel

family: Xie

full_name: Jing Xie

given: Jing

family: Mesnage

full_name: Valérie Mesnage

given: Valérie

family: Mondon

full_name: Karl Mondon

given: Karl

family: Viallet

full_name: François Viallet

given: François

family: Jedynak

full_name: Pierre Jedynak

family: Djebara

full_name: Mouna Ben Djebara

given: Mouna Ben

family: Schüpbach

full_name: Michael Schüpbach

given: Michael

family: Pelissolo

full_name: Antoine Pelissolo

given: Antoine

family: Vidailhet

full_name: Marie Vidailhet

given: Marie

family: Agid

full_name: Yves Agid

given: Yves

family: Houeto

full_name: Jean-Luc Houeto

given: Jean-Luc

family: Hartmann

full_name: Andreas Hartmann

given: Andreas

bso_classification: Biology (fond.)

currency_apc_doaj: USD

repository_institution: University of Geneva - Archive ouverte UNIGE

repository_institution: University Library Bern - BORIS - Bern Open Repository and Information System

title: Repetitive Behaviours in Patients with Gilles de la Tourette Syndrome: Tics, Compulsions, or Both?

location_facility: Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE