title: BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology

summary:
Diffuse large B-cell lymphomas (DLBCLs) represent 25 to 30% of adult non-Hodgkin lymphomas in western countries. DLBCLs are aggressive cancer but potentially curable with multi-agent chemotherapy. Whereas R-CHOP regimen has led to a marked improvement in survival, this disease remains a biologically heterogeneous entity. New therapeutic strategies are required including identification of patients' subgroups with different prognostic.

This project is based on BMS_LyTrans and Goelams 075 clinical trial. A study of whole blood transcriptome in 75 DLBCL patients and in 87 controls showed that PD-L1 (CD274) gene was overexpressed in DLBCL patients. Preliminary results demonstrated that PD-L1 is detected in plasma of DLBCL patients with a significantly higher concentration than in controls. This protein was selected as a potential biomarker because of its established role in anti-tumoral immunity. Interaction between PD-L1 and its receptor PD-1 is known to inhibit activation of immune responses by inducing T-lymphocytes anergy and/or apoptosis. Moreover, a direct involvement of PD-L1 in the protection of cancer cells from lysis by activated T lymphocytes has been demonstrated. PD-L1 expression has been described in several solid tumours, including ovary cancer, breast cancer, colon cancer, renal cell carcinoma, non-small cell lung carcinoma and in hematological malignancies such as T-NHL, MM and Hodgkin's lymphoma. Furthermore the expression of PD-L1 by tumour cells is associated with poor prognosis. The blockade of PD-L1/PD-1 axis may represent a novel therapeutic approach in aggressive cancers. These first results incite to identify the cells releasing soluble PD-L1 and to investigate its role in the anti-tumoral immunity in DLBCL patients.

The aim of this study is to identify cells producing soluble PD-L1 in DLBCL patients at diagnosis in comparison to others tumours known to express PD-L1 (metastatic breast cancer, Hodgkin's lymphoma, non-small cell lung cancer).

lead_sponsor: Rennes University Hospital

location_facility:
Rennes EFS
Institut Paoli Calmette
Montpellier University Hospital
Rennes University Hospital


title: The European Robotic Spinal Instrumentation (EUROSPIN) Study: A European Prospective Multicenter Multinational Pragmatic Trial on Robot-guided Versus Navigated Versus Freehand Pedicle Screw Fixation

acronym: EUROSPIN

summary: In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected. The three arms consist of robot-guided (RG), navigated (NV), or freehand (FH) screw insertion.

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

study_type: Observational

time_perspective: Prospective

enrollment_type: Anticipated

ReferenceType: background

ReferenceCitation: Goldstein CL, Phillips FM, Rampersaud YR. Comparative Effectiveness and Economic Evaluations of Open Versus Minimally Invasive Posterior or Transforaminal Lumbar Interbody Fusion: A Systematic Review. Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S74-89. doi: 10.1097/BRS.0000000000001462. Review.

ReferenceCitation: Hu X, Lieberman IH. What is the learning curve for robotic-assisted pedicle screw placement in spine surgery? Clin Orthop Relat Res. 2014 Jun;472(6):1839-44. doi: 10.1007/s11999-013-3291-1.

ReferenceCitation: Schatlo B, Martinez R, Alaid A, von Eckardstein K, Akhavan-Sigari R, Hahn A, Stockhammer F, Rohde V. Unskilled unawareness and the learning curve in robotic spine surgery. Acta Neurochir (Wien). 2015 Oct;157(10):1819-23; discussion 1823. doi: 10.1007/s00701-015-2535-0. Epub 2015 Aug 19.

ReferenceCitation: Marcus HJ, Cundy TP, Nandi D, Yang GZ, Darzi A. Robot-assisted and fluoroscopy-guided pedicle screw placement: a systematic review. Eur Spine J. 2014 Feb;23(2):291-7. doi: 10.1007/s00586-013-2879-1. Epub 2013 Jun 26. Review.

ReferenceCitation: Schröder ML, Staartjes VE. Revisions for screw malposition and clinical outcomes after robot-guided lumbar fusion for spondylolisthesis. Neurosurg Focus. 2017 May;42(5):E12. doi: 10.3171/2017.3.FOCUS16534.

ReferenceCitation: Molliqaj G, Schatlo B, Alaid A, Solomiichuk V, Rohde V, Schaller K, Tessitore E. Accuracy of robot-guided versus freehand fluoroscopy-assisted pedicle screw insertion in thoracolumbar spinal surgery. Neurosurg Focus. 2017 May;42(5):E14. doi: 10.3171/2017.3.FOCUS179.

ReferenceCitation: Schatlo B, Molliqaj G, Cuvinciuc V, Kotowski M, Schaller K, Tessitore E. Safety and accuracy of robot-assisted versus fluoroscopy-guided pedicle screw insertion for degenerative diseases of the lumbar spine: a matched cohort comparison. J Neurosurg Spine. 2014 Jun;20(6):636-43. doi: 10.3171/2014.3.SPINE13714. Epub 2014 Apr 11.

ReferenceCitation: Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med. 2001 Jul;33(5):337-43. Review.

ReferenceCitation: Fairbank JC, Couper J, Davies JB, O'Brien JP. The Oswestry low back pain disability questionnaire. Physiotherapy. 1980 Aug;66(8):271-3.

ReferenceCitation: Roland M, Morris R. A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. Spine (Phila Pa 1976). 1983 Mar;8(2):141-4.

ReferenceCitation: Ostelo RW, Deyo RA, Stratford P, Waddell G, Croft P, Von Korff M, Bouter LM, de Vet HC. Interpreting change scores for pain and functional status in low back pain: towards international consensus regarding minimal important change. Spine (Phila Pa 1976). 2008 Jan 1;33(1):90-4. doi: 10.1097/BRS.0b013e31815e3a10.

ReferenceCitation: R Core Team. R: A Language and Environment for Statistical Computing. (R Foundation for Statistical Computing, 2017).

ReferenceCitation: Staartjes VE, Klukowska AM, Schröder ML. Pedicle Screw Revision in Robot-Guided, Navigated, and Freehand Thoracolumbar Instrumentation: A Systematic Review and Meta-Analysis. World Neurosurg. 2018 Aug;116:433-443.e8. doi: 10.1016/j.wneu.2018.05.159. Epub 2018 May 31. Review.

ReferenceType: derived

ReferenceCitation: Staartjes VE, Molliqaj G, van Kampen PM, Eversdijk HAJ, Amelot A, Bettag C, Wolfs JFC, Urbanski S, Hedayat F, Schneekloth CG, Abu Saris M, Lefranc M, Peltier J, Boscherini D, Fiss I, Schatlo B, Rohde V, Ryang YM, Krieg SM, Meyer B, Kögl N, Girod PP, Thomé C, Twisk JWR, Tessitore E, Schröder ML. The European Robotic Spinal Instrumentation (EUROSPIN) study: protocol for a multicentre prospective observational study of pedicle screw revision surgery after robot-guided, navigated and freehand thoracolumbar spinal fusion. BMJ Open. 2019 Sep 8;9(9):e030389. doi: 10.1136/bmjopen-2019-030389.

family: Staartjes

full_name: Victor E Staartjes

given: Victor E

sequence: first

family: Molliqaj

full_name: Granit Molliqaj

given: Granit

sequence: additional

family: van Kampen

full_name: Paulien M van Kampen

given: Paulien M

family: Eversdijk

full_name: Hubert A J Eversdijk

given: Hubert A J

family: Amelot

full_name: Aymeric Amelot

given: Aymeric

family: Bettag

full_name: Christoph Bettag

given: Christoph

family: Wolfs

full_name: Jasper F C Wolfs

given: Jasper F C

family: Urbanski

full_name: Sophie Urbanski

given: Sophie

family: Hedayat

full_name: Farman Hedayat

given: Farman

family: Schneekloth

full_name: Carsten G Schneekloth

given: Carsten G

family: Abu Saris

full_name: Mike Abu Saris

given: Mike

family: Lefranc

full_name: Michel Lefranc

given: Michel

family: Peltier

full_name: Johann Peltier

given: Johann

family: Boscherini

full_name: Duccio Boscherini

given: Duccio

family: Fiss

full_name: Ingo Fiss

given: Ingo

family: Schatlo

full_name: Bawarjan Schatlo

given: Bawarjan

family: Rohde

full_name: Veit Rohde

given: Veit

family: Ryang

full_name: Yu-Mi Ryang

given: Yu-Mi

family: Krieg

full_name: Sandro M Krieg

given: Sandro M

family: Meyer

full_name: Bernhard Meyer

given: Bernhard

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

repository_institution: Technical University Munich - mediaTUM – the media and publications repository of the Technical University Munich

repository_institution: University of Geneva - Archive ouverte UNIGE

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - ParisTech

location_country: Austria Switzerland Netherlands France Germany

location_facility:
Ortho-Klinik Dortmund
Clinique de La Source
HUG Geneva
HELIOS Klinikum Berlin-Buch
Bergman Clinics
Medical University of Innsbruck
Martini Hospital
Amiens University Hospital
Klinikum Rechts der Isar
MC Haaglanden
St Josef Brothers Hospital
Universitätsmedizin Göttingen
La Pitié Salpetrière Hospital


type: Other Identifier

title: DEEP BRAIN STIMULATION FOR SEVERE DYSTONIA ASSOCIATED WITH WILSON'S DISEASE. A Prospective Multicenter Meta-analysis of Nof1 Trials

acronym: WILSTIM DBS

summary:
Dystonia in Wilson's disease represent a major issue. The persistence of disabling motor symptoms despite medical treatments justifies conducting a study on deep brain stimulation (DBS) in Wilson's disease (WD). For bradykinetic patients, subthalamic nucleus (STN) could be considered as a better target than the globus pallidus (GPi). For patients with hyperkinetic dystonia, the internal globus pallidus (GPi) will be chosen as the target of DBS.

The investigators hypothesize that STN DBS will improve Wilson's disease patients, who, despite copper chelators drugs, are still impaired by severe dystonia and akinesia (more or less associated with other movement disorders).

The investigators primary objective is to demonstrate the efficacy of STN/GPi DBS on dystonia associated with Wilson's disease.

Secondary objectives:

To evaluate the impact of STN/GPi DBS on other movements disorders (tremor, Parkinsonism, chorea) observed in Wilson's disease.
To describe cognitive status of patients and to evaluate the consequences of STN/GPi DBS on cognition and behavioral aspects of the disease.
To evaluate the consequences of the stimulation on speech and swallowing.
To evaluate the social impact of STN/GPi DBS in Wilson's disease.
To evaluate the safety of STN/GPi DBS in the specific context of Wilson's disease.

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

lead_sponsor: Hospices Civils de Lyon

location_facility:
Hopital Lariboisiere
Hospices Civils de Lyon

intervention_type: Device

lead_sponsor_type: academique

status_simplified: Ongoing


ReferenceCitation: Brigo F, Jones K, Eltze C, Matricardi S. Anti-seizure medications for Lennox-Gastaut syndrome. Cochrane Database Syst Rev. 2021 Apr 7;4:CD003277. doi: 10.1002/14651858.CD003277.pub4.

name: Department of Neurology; Hospital of Merano (SABES-ASDAA); Merano-Meran Italy

family: Brigo

full_name: Francesco Brigo

given: Francesco

name: Cochrane Neuromuscular; Queen Square Centre for Neuromuscular Diseases; London UK

name: Cochrane Pain, Palliative and Supportive Care; Oxford UK

family: Jones

full_name: Katherine Jones

given: Katherine

name: Great Ormond Street Hospital for Children NHS Foundation Trust; London UK

family: Eltze

full_name: Christin Eltze

given: Christin

name: Department of Child Neuropsychiatry; Children’s Hospital “G. Salesi”, Ospedali Riuniti Ancona; Ancona Italy

family: Matricardi

full_name: Sara Matricardi

given: Sara

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Cochrane Database of Systematic Reviews

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

ReferenceCitation: Auvin S, Williams B, McMurray R, Kumar D, Perdomo C, Malhotra M. Novel seizure outcomes in patients with Lennox-Gastaut syndrome: Post hoc analysis of seizure-free days in rufinamide Study 303. Epilepsia Open. 2019 Mar 13;4(2):275-280. doi: 10.1002/epi4.12314. eCollection 2019 Jun.

name: Pediatric Neurology Department & INSERM U1141Robert‐Debré University HospitalAPHP Paris France

family: Auvin

full_name: Stéphane Auvin

given: Stéphane

family: Williams

full_name: Betsy Williams

given: Betsy

family: McMurray

full_name: Rob McMurray

given: Rob

family: Kumar

full_name: Dinesh Kumar

given: Dinesh

family: Perdomo

full_name: Carlos Perdomo

given: Carlos

family: Malhotra

full_name: Manoj Malhotra

given: Manoj

currency_apc_doaj: USD

journal_name: Epilepsia Open

oa_colors: green gold

oa_host_type: publisher;repository

evidence: oa journal (via doaj)

host_type: publisher

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

license_normalized: no license

title: Novel seizure outcomes in patients with Lennox‐Gastaut syndrome: Post hoc analysis of seizure‐free days in rufinamide Study 303

ReferenceCitation: Arzimanoglou A, Ferreira J, Satlin A, Olhaye O, Kumar D, Dhadda S, Bibbiani F. Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303. Eur J Paediatr Neurol. 2019 Jan;23(1):126-135. doi: 10.1016/j.ejpn.2018.09.010. Epub 2018 Sep 27.

family: Arzimanoglou

full_name: Alexis Arzimanoglou

given: Alexis

family: Ferreira

full_name: Jose Ferreira

given: Jose

family: Satlin

full_name: Andrew Satlin

given: Andrew

family: Olhaye

full_name: Omar Olhaye

given: Omar

journal_name: European Journal of Paediatric Neurology

ReferenceCitation: Arzimanoglou A, Ferreira JA, Satlin A, Mendes S, Williams B, Critchley D, Schuck E, Hussein Z, Kumar D, Dhadda S, Bibbiani F. Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study. Eur J Paediatr Neurol. 2016 May;20(3):393-402. doi: 10.1016/j.ejpn.2015.12.015. Epub 2016 Jan 11.

location_country:
Italy
South Africa
France
Poland
Greece
United States
Canada

title: A Multicenter, Randomized, Controlled, Open-label Study to Evaluate the Cognitive Development Effects and Safety, and Pharmacokinetics of Adjunctive Rufinamide Treatment in Pediatric Subjects 1 to Less Than 4 Years of Age With Inadequately Controlled Lennox-Gastaut Syndrome

summary: This study was designed to evaluate the cognitive effect, safety, and pharmacokinetics (PK) of rufinamide on Lennox-Gastaut Syndrome (LGS) inadequately controlled in pediatric participants already taking other anti-epileptic drugs.


title: Identification of New Highly Antibiotic-resistant Bacteria Carriage Risk Factors to Optimize the Detection and Medical Care for Carriers Patients

acronym: CODBAHRE

summary: The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care for carriers these patients

status: Completed

study_completion_date_type: Actual

enrollment_type: Actual

ipd_sharing: Yes

lead_sponsor: Assistance Publique - Hôpitaux de Paris

status_simplified: Completed


title: Psycho-biological Substrates of Therapeutic Benefit of Thermal Cure on Generalized Anxiety Disorders (Insula-TOP)

acronym: Insula-TOP

summary: Multicenter study comparing paroxetine (n=30) versus thermal cure (n=30) in patients with a diagnosis of Generalised Anxiety Disorders

ReferenceCitation: Jaafari N, Rachid F, Rotge JY, Polosan M, El-Hage W, Belin D, Vibert N, Pelissolo A. Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: a review. World J Biol Psychiatry. 2012 Mar;13(3):164-77. doi: 10.3109/15622975.2011.575177. Epub 2011 May 30. Review.

ReferenceCitation: Jaafari N, Baup N, Bourdel MC, Olié JP, Rotge JY, Wassouf I, Sharov I, Millet B, Krebs MO. Neurological soft signs in OCD patients with early age at onset, versus patients with schizophrenia and healthy subjects. J Neuropsychiatry Clin Neurosci. 2011 Fall;23(4):409-16. doi: 10.1176/jnp.23.4.jnp409.

ReferenceCitation: Jaafari N, Aouizerate B, Tignol J, El-Hage W, Wassouf I, Guehl D, Bioulac B, Daniel ML, Lacoste J, Gil R, Burbaud P, Rotge JY; Insight Study Group. The relationship between insight and uncertainty in obsessive-compulsive disorder. Psychopathology. 2011;44(4):272-6. doi: 10.1159/000323607. Epub 2011 May 6. Erratum in: Psychopathology. 2011;44(5):319.

ReferenceCitation: Girard SL, Gauthier J, Noreau A, Xiong L, Zhou S, Jouan L, Dionne-Laporte A, Spiegelman D, Henrion E, Diallo O, Thibodeau P, Bachand I, Bao JY, Tong AH, Lin CH, Millet B, Jaafari N, Joober R, Dion PA, Lok S, Krebs MO, Rouleau GA. Increased exonic de novo mutation rate in individuals with schizophrenia. Nat Genet. 2011 Jul 10;43(9):860-3. doi: 10.1038/ng.886.

ReferenceCitation: Dubois O, Salamon R, Germain C, Poirier MF, Vaugeois C, Banwarth B, Mouaffak F, Galinowski A, Olié JP. Balneotherapy versus paroxetine in the treatment of generalized anxiety disorder. Complement Ther Med. 2010 Feb;18(1):1-7. doi: 10.1016/j.ctim.2009.11.003. Epub 2010 Jan 6.

lead_sponsor: Centre Hospitalier Henri Laborit

location_facility:
Centre Hospitalier Henri Laborit
Les thermes de Saujon

intervention_type: Other


title: BIOTRONIK - SaFety and Performance Registry for an aLl-comers Subject Population With the Limus Eluting Orsiro Mission Stent System Within Daily Clinical Practice: BIOFLOW-VIII

acronym: BIOFLOW-VIII

summary: The BIOFLOW-VIII registry is a post-market clinical evaluation of the Orsiro Mission stent in subjects requiring coronary revascularization with Drug Eluting Stents (DES).

ipd_sharing: No

ipd_sharing_description: The primary outcome data will be shared after publication of it.

lead_sponsor: Biotronik AG

location_facility:
Clinique Esquirol Saint Hilaire
GCS de cardiologie
CH d'Haguenau
Hôpital Privé de Bois Bernard
Hôpital Louis Pasteur
CH de Pau
Clinique Saint Joseph
CHU de Tours
CH de Bastia
CH de Tourcoing
Hôpital Privé Saint Martin
Centre de cardiologie d'Evecquemont
Clinique La Croix du Sud
Centre Cardiologique du Nord
CHU de Cermont Ferrand
Polyclinique Les Fleurs
Clinique du Millénaire
Nouvel Hopital Civil
Clinique Convert
Clinique du Diaconat
CH de Valence
Clinique Mutualiste
CH de Metz
CHU Félix Guyon
Hôpital Privé du Confluent
Hôpital Lariboisière
Clinique Axium
CHU Henri Mondor
Polyclinique Vauban
Clinique Sainte Clotilde
Hôpital Saint Joseph
CH de Toulon
CH Antibes
Clinique Pont de Chaume
Clinique Rhéna / GERC
CH Sud Francilien
Clinique Ambroise Paré
Nouvelle Clinique de Tours Plus
Hôpital Privé de l'Estuaire
CH de Vannes
Hôpital Marie Lannelongue
Polyclinique Saint Laurent
Centre Hospitalier de La Rochelle
Médpôle Lyon Villeurbanne

lead_sponsor_type: industriel


type: EudraCT Number

title: A Phase I/II Study of Metronomic Cyclophosphamide and Oncolytic Poxvirus JX-594 in Patients With Advanced Hormone-receptor Positive and Triple Negative Breast Cancer and Advanced Soft Tissue Sarcoma (METROmaJX)

acronym: METROmaJX

summary:
Assessment of the efficacy and safety of JX-594 and metronomic cyclophosphamide in patients with advanced soft-tissue sarcoma and advanced breast cancer, once the Maximum Tolerated Dose have been determined (phase I trial).

Phase I study: this is a prospective open-labeled phase I trial based on a dose escalating study design assessing two dose levels of JX594 when prescribed in combination with metronomic cyclophosphamide.

Phase II trials with two treatments strategies:

Metronomic CP + JX-594: phase II study sarcoma: this is a monocentric, randomized two-arm non comparative phase 2 study assessing efficacy and safety of JX-594 in association with metronomic cyclophosphamide in patients with advanced soft-tissue sarcoma.

Metronomic CP + JX-594: phase II study breast cancer: this is a monocentric, single-arm phase II study, assessing efficacy and safety of JX-594 in association with metronomic cyclophosphamide in patients with advanced breast cancer.

Metronomic CP + JX-594 + Avelumab: phase II study sarcoma: this is a monocentric, single arm phase II study assessing efficacy and safety of avelumab in combination with IT JX-594 and metronomic cyclophosphamide in patients with advanced soft-tissue sarcoma.

Metronomic CP + JX-594 + Avelumab:: phase II study breast cancer: this is a monocentric, single-arm phase II study, assessing efficacy and safety of avelumab in combination with IT JX-594 and metronomic cyclophosphamide in patients with advanced breast cancer.

lead_sponsor: Institut Bergonié

intervention_type: Drug


title: Prodige 26: Radiochemotherapy With and Without Dose Escalation in Patients Presenting Locally Advanced or Inoperable Carcinoma of the Oesophagus

acronym: CONCORDE

summary:
Exclusive concomitant radiochemotherapy (RCT) at a dose of 50 Gy delivered over 5 weeks, according to the RTOG 85-01 protocol, has led to improved 5-year survival in 25% of patients, whereas no patients survived for 5 years using radiotherapy alone for patients with esophageal cancer. Surgery, even when combined with preoperative RCT, also gives disappointing results for locally advanced tumors, which casts serious doubts on the usefulness of preoperative radiotherapy. By varying the fractionation schedule, the length of treatment or the radiotherapy volumes, it has become possible to obtain levels of loco-regional relapse of around 35 to 45%. After reviewing the results for loco-regional relapse according to the dose of radiation and the recommended radiotherapy volumes, we aimed to investigate why increasing the dose of radiation has no impact in esophageal cancers. Although INT-0123 phase III trial showed no benefit of dose escalation in esophageal cancer, some issues remain unclear as most of the patients who died in the experimental arm were treated above 50Gy. Moreover, only the tumor was treated up to 64Gy while involved nodes were not considered for dose escalation in this trial. In the RTOG 85-01phase III trial, an elective nodal irradiation from subclavicular fossa up to the esophagogastric junction was performed with a 2D technique, delivering 30Gy which could be considered as not appropriate.

In this randomized phase II/III trial, we aim to test an exclusive concomitant chemoradiotherapy for patients with non resectable esophageal cancer with a dose escalation up to 66Gy on the primary tumor as well as the involved nodes using a 3D conformal technique combined with a 40 Gy elective nodal irradiation on lymph node stations (as defined by the RTOG) with a risk of microscopic involvement ≥ 20%.

ReferenceCitation: Bednarek C, Crehange G, Quivrin M, Cueff A, Vulquin N, Chevalier C, Cerda T, Petegnief Y, Mazoyer F, Maingon P, Bosset JF, Servagi Vernat S. Mapping of failures after radiochemotherapy in patients with non-metastatic esophageal cancer: A posteriori analysis of the dose distribution in the sites of loco-regional relapse. Radiother Oncol. 2015 Aug;116(2):252-6. doi: 10.1016/j.radonc.2015.07.019. Epub 2015 Jul 27.

family: Bednarek

full_name: Coraline Bednarek

given: Coraline

family: Crehange

full_name: Gilles Crehange

given: Gilles

family: Quivrin

full_name: Magali Quivrin

given: Magali

family: Cueff

full_name: Adèle Cueff

given: Adèle

family: Vulquin

full_name: Noémie Vulquin

given: Noémie

family: Chevalier

full_name: Cédric Chevalier

given: Cédric

family: Cerda

full_name: Thomas Cerda

given: Thomas

family: Petegnief

full_name: Yolande Petegnief

given: Yolande

family: Mazoyer

full_name: Frédéric Mazoyer

given: Frédéric

family: Maingon

full_name: Philippe Maingon

given: Philippe

family: Bosset

full_name: Jean François Bosset

given: Jean François

family: Servagi Vernat

full_name: Stéphanie Servagi Vernat

given: Stéphanie

journal_name: Radiotherapy and Oncology

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

lead_sponsor: Centre Georges Francois Leclerc

intervention_type: Radiation


title: Prospective, Multicenter, Single-arm Clinical Investigation Evaluating the Safety, Performance and Clinical Benefit of a New Autotransfusion Device in Cardiac Surgery

acronym: i-TRANSEP

summary:
Blood transfusion is at the heart of the therapeutic arsenal when there is a hemorrhage and/or blood loss during a surgery. There are two types of transfusion: the homologous one (blood from a compatible donor) and the autologous or autotransfusion method (which is done with the patient's own blood).

Although homologous transfusions can save lives, it can cause significant adverse events. Since then, multiple solutions have been developed to avoid exposing patients to these risks. It is in this context that was born the "Patient Blood Management" (PBM). Thus, the strategy in this PBM has been defined as "the appropriate use of blood and blood components, with the aim of minimizing the use of allogeneic transfusions".

In this context, particular interest has been given to autologous transfusion or autotransfusion or cell salvage, the general purpose is to reduce (or even stop) the use of allogeneic products and to reduce the risks associated with the ABO compatibility system, as well as all the adverse effects associated with allogeneic plasma and platelet transfusions.

Most autotransfusers available on the market operate by centrifugation. Autotransfusion is already a solution in Patient Blood Management and its efficiency and safety have already been optimized. However, there is still a need to improve the quality of the treated blood with an easier-to-use device that could improve the quality of the blood concentrate.

Indeed, with the current devices, it may happen that the use of allogeneic transfusions, plasma and platelets transfusions, is necessary in addition to autologous red blood cells thus reducing the interest of autotransfusion.

It is in this context that i-SEP has developed a new autotransfusion device based on a filtration method. Unlike competing devices, the i-SEP device allows the concentration of not only red blood cells (as competitive devices) but also platelets.

In this study, the i-SEP device is used in typical clinical applications of autotransfusion: cardiovascular and orthopedic surgeries, where there is a risk of hemorrhage and/or blood loss for example ≥ 500mL in cardiac surgery and ≥ 300mL in orthopedic surgery.

The study includes a screening phase (≤ 21Days), surgery phase when the i-SEP device is used (Day 0), a post-surgery phase (Day 1 - Day 6), a first follow-up visit (Day 7 ± 3) and a second follow-up visit (Day 30 ± 7).

lead_sponsor: i-SEP

location_facility:
CHU de Bordeaux - GH Sud
CHU de Nantes
CHU de Bordeaux - GH Pellegrin
Ap-Hp - Hegp
CHU de Rennes


title: INGEVITY™ Observational Trial: Assessment of Routine Experience and Magnet Resonance Imaging (MRI) Usage With a New Lead for Bradycardia Pacing

acronym: GENTLE

summary:
The objectives of this registry are to

Collect clinical data on Boston Scientific's ImageReady MR Conditional Pacing Systems involving the INGEVITY lead based on observations / events
Gather data on actual number of MRI scans performed in the patient cohort implanted with an ImageReady system including information about scanned body parts.
Collect physician feedback on lead handling with the INGEVITY lead

in a real-life, market-released standard of care environment using devices on intended purpose and which are authorized to bear the CE (Communauté Européenne) marking / are approved for use in the applicable area of participating centers. No additional invasive or other burdensome examinations are to be carried out other than the ones conducted by the centers per their general standard of care.

lead_sponsor: Boston Scientific Corporation

location_country:
Italy
Austria
Sweden
Switzerland
Spain
France
Norway
Ireland
Belgium
Portugal
Germany
United Kingdom
Korea, Republic of

location_facility: Immanuel Klinikum Bernau/Herzzentrum Brandenburg

location_facility: Le Confluent - Nouvelles Cliniques Nantaises

location_facility: Centre Hospitalier Universitaire de Poitiers

location_facility: Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Klinik fur Kardiologie und Pulmologie

location_facility: Universitatsklinikum Dusseldorf, Klinik fur Kardiovaskulare Chrirurgie

location_facility: AKh - Allgemeines Krankenhaus der Stadt Linz GmbH

location_facility: Groupement Hospitalier Pitie Salpetriere

location_facility: Herz- und Gefäßzentrum am Krankenhaus Neu-Bethlehem

location_facility: Seoul National University Bundang Hospital

location_facility: Hospital Clinico Universitario Valladolid

location_facility: Hospital Professor Doutor Fernando Fonseca, EPE

location_facility: Unfallkrankenhaus Berlin, Klinik fur Innere Medizin

location_facility: Hospital Universitario Nuestra Senora de Candelaria


title: Impact of Early Intervention on the Global Development of Children With Autism Spectrum Disorder in a European French-speaking Population Dr Marie-Maude GEOFFRAY Le Vinatier Hospital

acronym: IDEA

summary:
Intervention for autism spectrum disorder (ASD) in European French-speaking countries is often heterogeneous and poorly evaluated. Six French-speaking early intervention units for children with ASD following the Early Start Denver Model (ESDM) have been created since 2011 with the common aim to evaluate effectiveness and cost-efficiency of the ESDM applied to the European French-speaking public health system. In those units, Children receive ESDM at minimum 12H per week by trained therapist. Therapist work in collaboration with parents (at home) and preschool or nursery.

The first aim of the investigators study is to evaluate the effectiveness of ESDM intervention 12 hours per week during 2 years on the global development of children with ASD compared to the interventions commonly available in the community.

ReferenceCitation: Touzet S, Occelli P, Schröder C, Manificat S, Gicquel L, Stanciu R, Schaer M, Oreve MJ, Speranza M, Denis A, Zelmar A, Falissard B, Georgieff N, Bahrami S, Geoffray MM; IDEA Study Group. Impact of the Early Start Denver Model on the cognitive level of children with autism spectrum disorder: study protocol for a randomised controlled trial using a two-stage Zelen design. BMJ Open. 2017 Mar 27;7(3):e014730. doi: 10.1136/bmjopen-2016-014730.

family: Touzet

full_name: Sandrine Touzet

given: Sandrine

family: Occelli

full_name: Pauline Occelli

given: Pauline

family: Schröder

full_name: Carmen Schröder

given: Carmen

family: Manificat

full_name: Sabine Manificat

given: Sabine

family: Gicquel

full_name: Ludovic Gicquel

given: Ludovic

family: Stanciu

full_name: Razvana Stanciu

given: Razvana

family: Schaer

full_name: Marie Schaer

given: Marie

family: Oreve

full_name: Marie-Joelle Oreve

given: Marie-Joelle

family: Speranza

full_name: Mario Speranza

given: Mario

family: Denis

full_name: Angelique Denis

given: Angelique

family: Zelmar

full_name: Amelie Zelmar

given: Amelie

family: Falissard

full_name: Bruno Falissard

given: Bruno

family: Georgieff

full_name: Nicolas Georgieff

given: Nicolas

family: Bahrami

full_name: Stephane Bahrami

given: Stephane

family: Geoffray

full_name: Marie-Maude Geoffray

given: Marie-Maude

currency_apc_doaj: GBP

journal_name: BMJ Open

license: cc-by-nc

license_normalized: cc-by-nc

repository_institution: Université Libre de Bruxelles - Dépôt institutionnel de l'Université libre de Bruxelles

publisher: BMJ


title: A Phase II Study Evaluating the Efficacy and Safety of Bortezomib (Velcade™) Combined With ACVBP Regimen in Patients With Previously Untreated Peripheral T-cell Lymphoma

summary: The purpose of this study is to determine the efficacy and the safety profile and toxicity of a combination of Velcade™ (bortezomib) with a standard chemotherapy regimen (ACVBP [doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone]) in the treatment of previously untreated patients with peripheral T-cell lymphoma (PTCL).

ReferenceCitation: Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, Fayad L, Dang NH, Samaniego F, Wang M, Broglio K, Samuels B, Gilles F, Sarris AH, Hart S, Trehu E, Schenkein D, Cabanillas F, Rodriguez AM. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol. 2005 Feb 1;23(4):667-75. Epub 2004 Dec 21.

ReferenceCitation: O'Connor OA, Wright J, Moskowitz C, Muzzy J, MacGregor-Cortelli B, Stubblefield M, Straus D, Portlock C, Hamlin P, Choi E, Dumetrescu O, Esseltine D, Trehu E, Adams J, Schenkein D, Zelenetz AD. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol. 2005 Feb 1;23(4):676-84. Epub 2004 Dec 21.

ReferenceCitation: Orlowski RZ. Proteasome inhibitors in cancer therapy. Methods Mol Biol. 2005;301:339-50. Review.

lead_sponsor: Lymphoma Study Association

location_country: Belgium France

location_facility: Groupe d'Etude des Lymphomes de l'Adulte

location_facility: Service d'Hématologie - Centre Hospitalier Lyon-Sud


title: Circulation of Pathogenic Fungi in the Domestic Environment: Clinical Impact of Mould and Pneumocystis Jirovecii Exposure on COPD Patients

acronym: FungiCOPD

summary:
Fungal infections could play a role in chronic obstructive pulmonary disease (COPD) patient's exacerbations and in lung function impairment. In fact, Aspergillus fumigatus is often isolated from respiratory samples, but few data are available about its clinical significance. Aspergillus colonization could be associated to a higher risk of invasive pulmonary aspergillosis (IPA), which, in COPD patients, is characterized by a 2% incidence (probably underestimated) and a high mortality (72 to 95%). Similarly, detection of anti-Aspergillus antibodies is quite frequent in COPD patients but its significance and usefulness for aspergillosis diagnosis and follow-up have not been assessed. Furthermore, several studies suggest a frequent carriage of Pneumocystis jirovecii, reaching 37-55%, with a higher frequency in the most severe COPD stages and a possible role of colonisation in the occurrence and progression of COPD.

As these colonization and sensitization phenomena could be related to domestic exposure to airborne or, for P. jirovecii, to human reservoirs, the investigators set-up a study in order to (i) Evaluate how domestic exposure to mould or to P. jirovecii could impact fungal colonization and sensitization frequency in COPD patients, (ii) Study the relationship between these fungal colonization/sensitization phenomena and lung function impairment in the course of COPD and (iii) Have a better understanding of mould and P. jirovecii circulation in the close environment of patients (between airborne, human reservoirs and patients).

In fine, this study will provide data (i) On fungal contamination levels (species and conidia concentration) of COPD patient's homes in a French region, (ii) On the relationship between fungal exposure level and colonization/sensitization phenomena, (iii) On the role of fungal colonization/sensitization in lung function impairment, (iv) To design diagnostic, therapeutic, and preventive options for the management of COPD patients, taking into account fungal environmental exposure and colonization/sensitization impact on the evolution of the disease.

lead_sponsor: University Hospital, Lille


title: Validation of a Method to Search Residual Disease in Auto-cryopreserved Ovarian Tissues

acronym: VMRDO

summary: Cryopreservation of ovarian tissue is offered to young girls and women aged under 35 who have to undergo sterilizing gonadotoxic treatment, with the aim of preserving their fertility. The main part of the ovary is preserved, as primordial and primary follicles are resistant to freezing / thawing protocols. In the absence of other techniques (in vivo maturation, injecting isolated ovarian follicles, etc.) autografting this cryopreserved tissue is currently the only technique allowing fertility to be restored. Autograft is possible only if the indication for ovary cryopreservation is a non-neoplastic pathology or a malignant pathology with a low risk of ovarian metastasis. In other cases of neoplastic pathologies, particularly in cases of acute leukemia, tissue cannot as yet be re-used due to the lack of any codified technique for evaluating residual disease (MRD). The team has for two years been developing and validating a technique to look for residual disease in fragments of ovarian cortex in cases of acute leukemia. This technique is based on an original protocol for dissociating ovarian tissue to obtain a population of isolated ovarian cells that may be analyzed by multicolor flow cytometry. The specificity and sensitivity of the technique have been demonstrated in an experimental model. This model consists in using 8 color flow cytometry to look for characterizable leukemia cells added in different dilutions to a population of isolated ovarian cells taken from model ovarian cortex and up to a dilution of 10-5. When the molecular markers were present on diagnosis, they were found by Real-Time Quantitative Polymerase Chain Reaction (RQ-PCR) with the same dilutions. The model tissue came from laparoscopic ovarian drilling in patients with polycystic ovary syndrome. The main objective of this project is to validate techniques that have been previously codified with different populations of leukemia cells that may be characterized. The investigators then aim to adapt and validate this technique to look for MRD using 8 color flow cytometry on cryopreserved fragments of ovarian cortex from leukemia patients that are at risk of metastasis. Secondary objectives will be to implement procedures for oncological qualification of grafts in cases of malignant pathology and to consider the recommendations for using this cryopreserved ovarian tissue through the autograft technique for these indications.

time_perspective: Other

ReferenceCitation: Roux C, Amiot C, Agnani G, Aubard Y, Rohrlich PS, Piver P. Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation. Fertil Steril. 2010 May 1;93(7):2413.e15-9. doi: 10.1016/j.fertnstert.2009.12.022. Epub 2010 Feb 1.

ReferenceCitation: Amiot C, Angelot-Delettre F, Zver T, Alvergnas-Vieille M, Saas P, Garnache-Ottou F, Roux C. Minimal residual disease detection of leukemic cells in ovarian cortex by eight-color flow cytometry. Hum Reprod. 2013 Aug;28(8):2157-67. doi: 10.1093/humrep/det126. Epub 2013 Apr 30.

ReferenceCitation: Fauque P, Ben Amor A, Joanne C, Agnani G, Bresson JL, Roux C. Use of trypan blue staining to assess the quality of ovarian cryopreservation. Fertil Steril. 2007 May;87(5):1200-7. Epub 2007 Feb 20.

ReferenceCitation: Zver T, Alvergnas-Vieille M, Garnache-Ottou F, Ferrand C, Roux C, Amiot C. Minimal residual disease detection in cryopreserved ovarian tissue by multicolor flow cytometry in acute myeloid leukemia. Haematologica. 2014 Dec;99(12):e249-52. doi: 10.3324/haematol.2014.113373. Epub 2014 Sep 19.

ReferenceCitation: Zver T, Alvergnas-Vieille M, Garnache-Ottou F, Roux C, Amiot C. A new method for evaluating the risk of transferring leukemic cells with transplanted cryopreserved ovarian tissue. J Assist Reprod Genet. 2015 Aug;32(8):1263-6. doi: 10.1007/s10815-015-0512-4. Epub 2015 Jul 3.

lead_sponsor: Centre Hospitalier Universitaire de Besancon


title: Pilot Study on the Efficacy of Pegylated Interferon-Ribavirin-Boceprevir Triple Therapy in Patients Infected With Genotype 1 HCV With Cirrhosis and Awaiting Liver Transplantation (ANRS HC 29 BOCEPRETRANSPLANT)

summary: Evaluation of efficacy of triple therapy with pegylated interferon, ribavirin, and boceprevir in patients with genotype 1 chronic hepatitis C, who are treatment-naive, have relapsed, or are non-responders with cirrhosis and awaiting liver transplantation, with a MELD score less than or equal to 18

lead_sponsor: French National Agency for Research on AIDS and Viral Hepatitis

location_facility:
A Michallon Hospital
Claude Huriez hospital
Archet Hospital
Purpan Hospital
Nancy Hospital
Henri Mondor Hospital
Saint-Eloi Hospital
Haut-Lévêque Hospital
Purpan Hospital Médecine interne
La Pitié Salpétrière Hospital
Beaujon Hospital
Civil Hospital
Paul Brousse Hospital
La Conception Hospital
Cochin Hospital
Trousseau Hospital
Pontchaillou Hospital
Staint Antoine Hospital
La Croix-Rousse


title: Depression in Adolescents. A Cerebral Structural, Diffusion, and Functional Magnetic Resonance Imaging Study.

acronym: ADODEP

summary:
Adolescence is a critical period for the development of depressive disorders. As adolescence also is a critical period for brain maturation, it may be hypothesized that maturation changes in emotional circuits could underlie vulnerability for depression.

The aims of the study are (1) to identify the changes in brain morphometry, white matter microstructure, and functioning, in networks associated with depression features in adolescents, and (2) to assess the effects of treated pathology on brain structure by comparing the neuroimaging measures obtained in adolescents at inclusion with those at follow-up.

status: Unknown status

design_allocation: Non-Randomized

primary_purpose: Basic Science

lead_sponsor: Centre Hospitalier St Anne

status_simplified: Unknown


title: Comparison of Humoral Response to Conjugate Pneumococcal Vaccine and Polysaccharide Pneumococcal Vaccine in Rheumatoid Arthritis (RA) Patients Treated With Abatacept

acronym: VACINA

summary:
Is pneumococcal conjugate vaccine (which induces a T-dependent humoral response) more efficient than pneumococcal polysaccharide vaccine (which induces a T-independent humoral response) in RA patients treated with abatacept, biotherapy targeting T-cells? The investigator propose to conduct a prospective, multicenter (11 centers), randomized, open-label study.

The patients are going to be randomized in 2 groups: patients of the first group will be vaccinated with the polysaccharide pneumococcal vaccine (Pneumo23®/Pneumovax®) whereas patients of the second group will be vaccinated with conjugate pneumococcal vaccine (Prevenar13®).

primary_purpose: Prevention

lead_sponsor: University Hospital, Montpellier

location_country: Monaco France

location_facility:
CHU Hautepierre
CHU Montpied
CHU Carémeau
CHU Pellegrin
CHU Bicêtre
CHU La pitié salpétriere
CHRU de Montpellier
CHU Orléans
CHRU Roger Salengro
CHPG Monaco
CHU Nord


type: Registry Identifier

title: " Etude du Transcriptome Complet Lors du Syndrome Post-arrêt Cardiaque " Transcriptome Assessment After Cardiac Arrest

acronym: OMECARD

summary: The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.

primary_purpose: Diagnostic

location_facility: Hôpital Cochin, Assistance Publique Hôpitaux de Paris

intervention_type: Biological


title: Influence Of Nutritional Status Of Patients In The Intensive Care Output On Long Term Fate

acronym: FEEDING

summary:
It is established that the surviving patients after a stay in the ICU are characterized by frequent malnutrition and morbidity and mortality. The main goal of this work is to study the relationship between nutritional statuses during ICU hospitalization, whatever its determinants, and quality of life, morbidity and mortality at one year.

The hypothesis of the study is that the presence of under nutrition is responsible for a 10% increase in crude mortality at one year (which would be respectively 30% for malnourished patients and 20% for non-malnourished patients).

lead_sponsor: University Hospital, Clermont-Ferrand


title: Computed Tomography for Coronavirus Disease 19 Diagnosis

acronym: STOIC

summary: The purpose of this study is to build a large dataset of Computed Tomography (CT) images for identification of accurate CT criteria and development of deep learning-based solutions for diagnosis, quantification and prognostic estimation.

time_perspective: Retrospective

ReferenceCitation: Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020 Aug;296(2):E32-E40. doi: 10.1148/radiol.2020200642. Epub 2020 Feb 26.

ReferenceCitation: Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11. Erratum in: Lancet. 2020 Mar 28;395(10229):1038. Lancet. 2020 Mar 28;395(10229):1038.

family: Zhou

full_name: Fei Zhou

given: Fei

family: Yu

full_name: Ting Yu

given: Ting

family: Du

full_name: Ronghui Du

given: Ronghui

family: Fan

full_name: Guohui Fan

given: Guohui

family: Liu

full_name: Ying Liu

given: Ying

full_name: Zhibo Liu

given: Zhibo

family: Xiang

full_name: Jie Xiang

given: Jie

family: Wang

full_name: Yeming Wang

given: Yeming

family: Song

full_name: Bin Song

given: Bin

family: Gu

full_name: Xiaoying Gu

given: Xiaoying

family: Guan

full_name: Lulu Guan

given: Lulu

family: Wei

full_name: Yuan Wei

given: Yuan

family: Li

full_name: Hui Li

given: Hui

family: Wu

full_name: Xudong Wu

given: Xudong

family: Xu

full_name: Jiuyang Xu

given: Jiuyang

family: Tu

full_name: Shengjin Tu

given: Shengjin

family: Zhang

full_name: Yi Zhang

given: Yi

family: Chen

full_name: Hua Chen

given: Hua

family: Cao

full_name: Bin Cao

journal_name: The Lancet

oa_colors: green hybrid

evidence: open (via free pdf)

license: implied-oa

license_normalized: implied-oa

ReferenceCitation: Ko WC, Rolain JM, Lee NY, Chen PL, Huang CT, Lee PI, Hsueh PR. Arguments in favour of remdesivir for treating SARS-CoV-2 infections. Int J Antimicrob Agents. 2020 Apr;55(4):105933. doi: 10.1016/j.ijantimicag.2020.105933. Epub 2020 Mar 6.

ReferenceCitation: Revel MP, Boussouar S, de Margerie-Mellon C, Saab I, Lapotre T, Mompoint D, Chassagnon G, Milon A, Lederlin M, Bennani S, Molière S, Debray MP, Bompard F, Dangeard S, Hani C, Ohana M, Bommart S, Jalaber C, El Hajjam M, Petit I, Fournier L, Khalil A, Brillet PY, Bellin MF, Redheuil A, Rocher L, Bousson V, Rousset P, Grégory J, Deux JF, Dion E, Valeyre D, Porcher R, Jilet L, Abdoul H. Study of Thoracic CT in COVID-19: The STOIC Project. Radiology. 2021 Oct;301(1):E361-E370. doi: 10.1148/radiol.2021210384. Epub 2021 Jun 29.

name: Université de Paris, APHP, Hôpital Cochin, Dept of                     Radiology, Paris, France

name: Sorbonne Université, APHP, Hôpital Pitié                     Salpétrière, Dept of Radiology, Paris, France

name: Université de Paris, APHP, Hôpital Saint-Louis, Dept of                     Radiology, Paris, France

name: Université Rennes1, Hôpital Pontchaillou, Dept of                     Radiology, Rennes, France

name: Université Paris-Saclay, APHP, Hôpital Raymond                     Poincaré, Dept of Radiology, Garches, France

name: Sorbonne Université, APHP, Hôpital Tenon, Dept of                     Radiology, Paris, France

name: Université de Strasbourg, Hôpital de Hautepierre, Dept                     of Radiology, Strasbourg, France

name: Université de Paris, APHP, Hôpital Bichat, Dept of                     Radiology, Paris, France

name: Université de Strasbourg, Nouvel Hôpital Civil, Dept of                     Radiology, Strasbourg, France

name: Université de Montpellier, Hôpital Arnaud de                     Villeneuve, Dept of Radiology, Montpellier France

name: Université Paris-Saclay, APHP, Hôpital Ambroise                     Paré, Dept of Radiology, Boulogne, France

name: Université de Lorraine, Hôpital Brabois, Dept of                     Radiology, Vandoeuvre, France

name: Université de Paris, APHP, Hôpital Européen                     Georges Pompidou, Dept of Radiology, INSERM U970, PARCC, Paris, France

name: Sorbonne Université, APHP, Hôpital Avicenne, Dept of                     Radiology, Bobigny, France

name: Université Paris-Saclay, APHP, Hôpital Bicêtre,                     Dept of Radiology, Le Kremlin-Bicêtre, France

name: Université Paris-Saclay, APHP, Hôpital Antoine                     Béclère, Dept of Radiology, Clamart, France

name: Université de Paris, APHP, Hôpital                     Lariboisière, Dept of Radiology, Paris, France

name: Université Claude Bernard Lyon 1, Hospices Civils de Lyon,                     Hôpital Lyon Sud, Dept of Radiology, Pierre-Benite, France

name: Université de Paris, APHP, Hôpital Beaujon, Dept of                     Radiology, Clichy, France

name: Université Paris Est, APHP, Dept of Radiology, Hôpital                     Henri Mondor, Créteil, France

name: Université de Paris, APHP, Hôtel-Dieu, Dept of                     Radiology, Paris, France

name: Sorbonne Université, APHP, Hôpital Avicenne, Dept of                     Pneumology, Bobigny, INSERM UMR 1272, France

name: Université de Paris, APHP, Hôtel-Dieu, Dept of                     Clinical Epidemiology, Paris, France

name: Université de Paris APHP, Clinical Research Unit Paris                     Centre, Paris, France

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Sorbonne Paris Nord

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

publisher: Radiological Society of North America (RSNA)


title: Comparison of the Effectiveness of 2 Manual Therapies on Functional Outcome in Sub-acute and Chronic Non-specific Low Back Pain at 3 Months : a Randomised Controlled Trial

acronym: LC OSTEO

summary: The purpose of this study is to determine whether a standardised osteopathic manipulative treatment is more effective than a placebo of osteopathic manipulative treatment, in sub-acute and chronic non-specific low back pain on functional recovery at 3 months.

ReferenceCitation: 1. Poiraudeau S, Lefèvre-Colau M.-M, Fayad F., Rannou F, Revel M. Lombalgie. Encyclopédie Médico-Chirurgicale 15-840-C-10 (2004)

ReferenceCitation: Chou R, Huffman LH; American Pain Society; American College of Physicians. Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 2007 Oct 2;147(7):505-14. Review. Erratum in: Ann Intern Med. 2008 Feb 5;148(3):247-8.

ReferenceCitation: Nelemans PJ, de Bie RA, de Vet HC, Sturmans F. WITHDRAWN: Injection therapy for subacute and chronic benign low-back pain. Cochrane Database Syst Rev. 2007 Jul 18;(2):CD001824. Review.

ReferenceCitation: Hayden JA, van Tulder MW, Malmivaara AV, Koes BW. Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med. 2005 May 3;142(9):765-75.

ReferenceCitation: Costa LO, Maher CG, Latimer J, Hodges PW, Herbert RD, Refshauge KM, McAuley JH, Jennings MD. Motor control exercise for chronic low back pain: a randomized placebo-controlled trial. Phys Ther. 2009 Dec;89(12):1275-86. doi: 10.2522/ptj.20090218. Epub 2009 Nov 5.

ReferenceCitation: Lambeek LC, van Mechelen W, Knol DL, Loisel P, Anema JR. Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life. BMJ. 2010 Mar 16;340:c1035. doi: 10.1136/bmj.c1035.

ReferenceCitation: Lindell O, Johansson SE, Strender LE. Subacute and chronic, non-specific back and neck pain: cognitive-behavioural rehabilitation versus primary care. A randomized controlled trial. BMC Musculoskelet Disord. 2008 Dec 30;9:172. doi: 10.1186/1471-2474-9-172.

ReferenceCitation: Macario A, Pergolizzi JV. Systematic literature review of spinal decompression via motorized traction for chronic discogenic low back pain. Pain Pract. 2006 Sep;6(3):171-8. Review.

ReferenceCitation: Assendelft WJ, Morton SC, Yu EI, Suttorp MJ, Shekelle PG. Spinal manipulative therapy for low back pain. A meta-analysis of effectiveness relative to other therapies. Ann Intern Med. 2003 Jun 3;138(11):871-81. Review.

ReferenceCitation: Bronfort G, Haas M, Evans RL, Bouter LM. Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. Spine J. 2004 May-Jun;4(3):335-56. Review.

ReferenceCitation: Manheimer E, White A, Berman B, Forys K, Ernst E. Meta-analysis: acupuncture for low back pain. Ann Intern Med. 2005 Apr 19;142(8):651-63. Review. Erratum in: Ann Intern Med. 2005 Jun 7;142(11):950-1.

ReferenceCitation: Rubinstein SM, van Middelkoop M, Kuijpers T, Ostelo R, Verhagen AP, de Boer MR, Koes BW, van Tulder MW. A systematic review on the effectiveness of complementary and alternative medicine for chronic non-specific low-back pain. Eur Spine J. 2010 Aug;19(8):1213-28. doi: 10.1007/s00586-010-1356-3. Epub 2010 Mar 14. Review.

ReferenceCitation: Licciardone JC, Brimhall AK, King LN. Osteopathic manipulative treatment for low back pain: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2005 Aug 4;6:43. Review.

ReferenceCitation: Andersson GB, Lucente T, Davis AM, Kappler RE, Lipton JA, Leurgans S. A comparison of osteopathic spinal manipulation with standard care for patients with low back pain. N Engl J Med. 1999 Nov 4;341(19):1426-31.

ReferenceCitation: Licciardone JC, Stoll ST, Fulda KG, Russo DP, Siu J, Winn W, Swift J Jr. Osteopathic manipulative treatment for chronic low back pain: a randomized controlled trial. Spine (Phila Pa 1976). 2003 Jul 1;28(13):1355-62.

ReferenceCitation: Hoehler FK, Tobis JS, Buerger AA. Spinal manipulation for low back pain. JAMA. 1981 May 8;245(18):1835-8.

ReferenceCitation: Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010 Mar 23;340:c332. doi: 10.1136/bmj.c332.

ReferenceCitation: Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P; CONSORT Group. Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med. 2008 Feb 19;148(4):295-309.

ReferenceCitation: Nguyen C, Boutron I, Zegarra-Parodi R, Baron G, Alami S, Sanchez K, Daste C, Boisson M, Fabre L, Krief P, Krief G, Lefèvre-Colau MM, Rannou F. Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial. JAMA Intern Med. 2021 May 1;181(5):620-630. doi: 10.1001/jamainternmed.2021.0005.

name: UFR de Médecine, Faculté de Santé, Université de Paris, Paris, France

name: AP-HP.Centre-Université de Paris, Hôpital Cochin, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Paris, France

name: INSERM UMRS-1124, Toxicité Environnementale, Cibles Thérapeutiques, Signalisation Cellulaire et Biomarqueurs (T3S), Campus Saint-Germain-des-Prés, Paris, France

family: Nguyen

full_name: Christelle Nguyen

given: Christelle

name: AP-HP.Centre-Université de Paris, Hôpital Hôtel-Dieu, Centre d’Épidémiologie Clinique, Paris, France

name: INSERM UMRS-1153, Centre de Recherche Épidémiologie et Statistique, METHODS Team, Paris, France

family: Boutron

full_name: Isabelle Boutron

given: Isabelle

name: A.T. Still Research Institute, A.T. Still University, Kirksville, Missouri

name: School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland

family: Zegarra-Parodi

full_name: Rafael Zegarra-Parodi

given: Rafael

family: Baron

full_name: Gabriel Baron

given: Gabriel

name: Cabinet d'Études Sociologiques Interlis, Paris, France

family: Alami

full_name: Sophie Alami

given: Sophie

family: Sanchez

full_name: Katherine Sanchez

given: Katherine

name: INSERM UMR-S 1153, Centre de Recherche Épidémiologie et Statistique, ECaMO Team, Paris, France

family: Daste

full_name: Camille Daste

given: Camille

family: Boisson

full_name: Margaux Boisson

given: Margaux

family: Fabre

full_name: Laurent Fabre

given: Laurent

name: Department Health Work Environment, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Epalinges-Lausanne, Switzerland

family: Krief

full_name: Peggy Krief

given: Peggy

full_name: Guillaume Krief

given: Guillaume

name: Institut Fédératif de Recherche sur le Handicap, Paris, France

family: Lefèvre-Colau

full_name: Marie-Martine Lefèvre-Colau

given: Marie-Martine

family: Rannou

full_name: François Rannou

given: François

journal_name: JAMA Internal Medicine

oa_host_type: repository

repository_institution: HES-SO (https://www.hes-so.ch/) - ArODES

publisher: American Medical Association (AMA)

publisher_dissemination: American Medical Association

publisher_group: American Medical Association

publisher_normalized: American Medical Association


title: Human Intestinal Microbiota in Obesity and Nutritional Transition

acronym: Micro-Obes

summary: The objectives of this study are: 1-To qualify the relationship between the gut microbiota and the host nutritional and metabolic status during dietary transition.2-To define the impact of nutritional transition on the intestinal microbiota and identify metagenomics signatures of nutritional transition.

primary_purpose: Health Services Research

ReferenceCitation: Dao MC, Sokolovska N, Brazeilles R, Affeldt S, Pelloux V, Prifti E, Chilloux J, Verger EO, Kayser BD, Aron-Wisnewsky J, Ichou F, Pujos-Guillot E, Hoyles L, Juste C, Doré J, Dumas ME, Rizkalla SW, Holmes BA, Zucker JD, Clément K; MICRO-Obes Consortium. A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity. Front Physiol. 2019 Feb 5;9:1958. doi: 10.3389/fphys.2018.01958. eCollection 2018.

family: Dao

full_name: Maria Carlota Dao

given: Maria Carlota

family: Sokolovska

full_name: Nataliya Sokolovska

given: Nataliya

family: Brazeilles

full_name: Rémi Brazeilles

given: Rémi

family: Affeldt

full_name: Séverine Affeldt

given: Séverine

family: Pelloux

full_name: Véronique Pelloux

given: Véronique

family: Prifti

full_name: Edi Prifti

given: Edi

family: Chilloux

full_name: Julien Chilloux

given: Julien

family: Verger

full_name: Eric O. Verger

given: Eric O.

family: Kayser

full_name: Brandon D. Kayser

given: Brandon D.

family: Aron-Wisnewsky

full_name: Judith Aron-Wisnewsky

given: Judith

family: Ichou

full_name: Farid Ichou

given: Farid

family: Pujos-Guillot

full_name: Estelle Pujos-Guillot

given: Estelle

family: Hoyles

full_name: Lesley Hoyles

given: Lesley

family: Juste

full_name: Catherine Juste

given: Catherine

family: Doré

full_name: Joël Doré

given: Joël

family: Dumas

full_name: Marc-Emmanuel Dumas

given: Marc-Emmanuel

family: Rizkalla

full_name: Salwa W. Rizkalla

given: Salwa W.

family: Holmes

full_name: Bridget A. Holmes

given: Bridget A.

family: Zucker

full_name: Jean-Daniel Zucker

given: Jean-Daniel

family: Clément

full_name: Karine Clément

given: Karine

bso_classification: Biology (fond.)

journal_name: Frontiers in Physiology

license: cc-by

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Institut | Nicod

repository_institution: Nottingham Trent Repository - Nottingham Trent University's Institutional Repository

ReferenceCitation: Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016 Mar;65(3):426-36. doi: 10.1136/gutjnl-2014-308778. Epub 2015 Jun 22.

repository_institution: University of Oxford - Oxford Academic Notes & Queries

repository_institution: University of Westminster - WestminsterResearch

title: Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

ReferenceCitation: Kong LC, Holmes BA, Cotillard A, Habi-Rachedi F, Brazeilles R, Gougis S, Gausserès N, Cani PD, Fellahi S, Bastard JP, Kennedy SP, Doré J, Ehrlich SD, Zucker JD, Rizkalla SW, Clément K. Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. PLoS One. 2014 Oct 20;9(10):e109434. doi: 10.1371/journal.pone.0109434. eCollection 2014.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: The Pennsylvania State University - CiteSeer X

repositories:
CiteSeerX
HAL
PubMed Central
pdfs.semanticscholar.org

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

title: Dietary Patterns Differently Associate with Inflammation and Gut Microbiota in Overweight and Obese Subjects

ReferenceCitation: Kong LC, Wuillemin PH, Bastard JP, Sokolovska N, Gougis S, Fellahi S, Darakhshan F, Bonnefont-Rousselot D, Bittar R, Doré J, Zucker JD, Clément K, Rizkalla S. Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach. Am J Clin Nutr. 2013 Dec;98(6):1385-94. doi: 10.3945/ajcn.113.058099. Epub 2013 Oct 30.

journal_name: The American Journal of Clinical Nutrition


title: Prospective, Multicentre, Open-label Study Evaluating the Immunogenicity and Safety of Influenza Vaccine in Patients With Inflammatory Bowel Disease (IBD) Receiving or Not Immunosuppressive Therapy

acronym: MICIVAX

summary:
The primary purpose of the study is to compare the efficacy and safety of influenza vaccine in patients with inflammatory bowel disease (IBD) receiving immunosuppressive therapy with patients not receiving immunosuppressants .

The main objective of the study is to evaluate the humoral immunogenicity of influenza vaccination in patients with IBD

ReferenceCitation: Launay O, Abitbol V, Krivine A, Slama LB, Bourreille A, Dupas JL, Hébuterne X, Savoye G, Deplanque D, Bouhnik Y, Pelletier AL, Galtier F, Laharie D, Nachury M, Zerbib F, Allez M, Bommelaer G, Duclos B, Lucht F, Gougeon ML, Tartour E, Rozenberg F, Hanslik T, Beaugerie L, Carrat F; MICIVAX Study Group. Immunogenicity and Safety of Influenza Vaccine in Inflammatory Bowel Disease Patients Treated or not with Immunomodulators and/or Biologics: A Two-year Prospective Study. J Crohns Colitis. 2015 Dec;9(12):1096-107. doi: 10.1093/ecco-jcc/jjv152. Epub 2015 Sep 7.

family: Launay

full_name: Odile Launay

given: Odile

family: Abitbol

full_name: Vered Abitbol

given: Vered

family: Krivine

full_name: Anne Krivine

given: Anne

family: Slama

full_name: Lilia Ben Slama

given: Lilia Ben

family: Bourreille

full_name: Arnaud Bourreille

given: Arnaud

family: Dupas

full_name: Jean Louis Dupas

given: Jean Louis

family: Hébuterne

full_name: Xavier Hébuterne

given: Xavier

family: Savoye

full_name: Guillaume Savoye

given: Guillaume

family: Deplanque

full_name: Dominique Deplanque

given: Dominique

family: Bouhnik

full_name: Yoram Bouhnik

given: Yoram

family: Pelletier

full_name: Anne Laure Pelletier

given: Anne Laure

family: Galtier

full_name: Florence Galtier

given: Florence

family: Laharie

full_name: David Laharie

given: David

family: Nachury

full_name: Maria Nachury

given: Maria

family: Zerbib

full_name: Frank Zerbib

given: Frank

family: Allez

full_name: Mathieu Allez

given: Mathieu

family: Bommelaer

full_name: Gilles Bommelaer

given: Gilles

family: Duclos

full_name: Bernard Duclos

given: Bernard

family: Lucht

full_name: Frederic Lucht

given: Frederic

family: Gougeon

full_name: Marie-Lise Gougeon

given: Marie-Lise

family: Tartour

full_name: Eric Tartour

given: Eric

family: Rozenberg

full_name: Flore Rozenberg

given: Flore

family: Hanslik

full_name: Thomas Hanslik

given: Thomas


title: TEXTO : Total EXposure To Organic Pollutants

acronym: TEXTO

summary:
People are, especially in industrialized countries, exposed to a growing number of ubiquitous chemical substances. It thus increases human exposure pathways: diet, inhalation, soil and dust dermal contact…), notably for semi-volatile organic compounds. Diet is generally sought to contribute the most to total exposure for many chemicals, the relative contribution of each pathway is nevertheless poorly described, and can be different among populations. This is in particularly the case For young children, who can be more exposed via the environment, because of frequent contact with object and dust and hand to mouth behaviors. Children are in addition considered more sensitive to chemical risk due to their maturating systems.

In this context, the objective of this project is to characterize the young children's exposure to a particular class of semi volatile organic compounds. It will encompass the relative contribution of different pathways to the external dose, and to try to match the internal and external doses with a physiologically based pharmacokinetic (PBPK) model for molecules for which it is possible.

The present demand concerns a feasibility study on 2 children, for Perfluorinated Alkylated Substances (PFAS), used in numerous consumer products.

status: Withdrawn


title: Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes: a Double Blind Randomized Controlled Trial

summary:
Vascular calcification (VC) is a complication frequently observed in elderly, in chronic kidney disease (CKD) and in diabetes (particularly in type 1 diabetes). VC is a dynamic pathophysiological process that causes cardiovascular morbidity and is an independent risk factor of major amputation. In vitro and human observational studies have suggested a role of metformin in preventing VC. The investigators propose to test the effect of metformin treatment during two years on lower limb arterial calcification evaluated by CT-scan in patients with type 1 diabetes and without CKD.

This research is a phase III double blind randomized controlled trial consisting of 2 years double-blind treatment phase (patients randomized to metformin or placebo) in type 1 diabetic patients.

The participants and the investigators will be blinded to the study medications taken during the double-blind treatment period

ipd_sharing_description:
Data are available upon reasonable request The procedures carried out with the French data privacy authority (CNIL, National Commission for Information Technology and Freedoms) do not provide for the transmission of the database, nor do the information and consent documents signed by the patients.

Consultation by the editorial board or interested researchers of individual participant data that underlie the results reported in the article after deidentification may nevertheless be considered, subject to prior determination of the terms and conditions of such consultation and in respect for compliance with the applicable regulations.

location_facility: Pitié Salpêtrière Hospital, AP-HP, Diabetology department


title: Profile of COPD Patients Refusing Educational Program in Pulmonary Rehabilitation and Impact on the Benefits

summary:
Pulmonary rehabilitation (PR) has proven its efficacy to improve dyspnea, health status, exercise tolerance and quality of life for patients with stable Chronic Obstructive Pulmonary Disease (COPD). Exercise training has previously been thoroughly studied but education has been less studied in PR. Furthermore, only few studies have investigated the added value of an educational program (EP) to exercise training on clinical and physical factors. Characterizing those patients who refuse EP is therefore a first step to better target them and potentially improve their adherence and outcome following PR.

The aim of this study was to determine the characteristics of the COPD patients referred to PR who refused EP compare to those who accepted and to identify the independent predictive factors of refusal. The investigators also sought to compare the change in clinical outcomes and number and length of hospitalization at six months following PR among those patients who accepted or not to participate in EP.

ReferenceCitation: Smondack P, Gravier FE, Combret Y, Muir JF, Cuvelier A, Debeaumont D, Medrinal C, Prieur G, Bonnevie T. Factors influencing participation in educational workshops as part of a pulmonary rehabilitation program in patients with chronic obstructive pulmonary disease: a retrospective study. Expert Rev Respir Med. 2021 Nov 2:1-9. doi: 10.1080/17476348.2022.1991793. [Epub ahead of print]

name: ADIR Association, Rouen University Hospital, Rouen, France;

family: Smondack

full_name: Pauline Smondack

given: Pauline

name: Normandie University, UNIROUEN, UPRES EA 3830, Rouen University Hospital, Haute-Normandie Research and Biomedical Innovation, Rouen, France;

family: Gravier

full_name: Francis-Edouard Gravier

given: Francis-Edouard

name: Intensive Care Unit Deparment, Le Havre Hospital, Le Havre, France;

family: Combret

full_name: Yann Combret

given: Yann

name: Pulmonary, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital, Rouen, France;

family: Muir

full_name: Jean-François Muir

given: Jean-François

family: Cuvelier

full_name: Antoine Cuvelier

given: Antoine

name: Department of Respiratory and Exercise Physiology and CIC-CRB 1404, Rouen University Hospital, Rouen, France;

family: Debeaumont

full_name: David Debeaumont

name: Université Paris-Saclay, UVSQ, Erphan, Versailles, France;

family: Medrinal

full_name: Clément Medrinal

given: Clément

family: Prieur

full_name: Guillaume Prieur

family: Bonnevie

full_name: Tristan Bonnevie

given: Tristan

journal_name: Expert Review of Respiratory Medicine

publisher: Informa UK Limited

publisher_dissemination: Informa

publisher_group: Informa

publisher_normalized: Informa

lead_sponsor: ADIR Association


title: Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Role of Anisakidae and/or Fish Flesh Antigens in Fish Allergies.

summary:
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic diseases agents, and have a high impact on human health.

Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but allergic symptoms can also occur in isolation, after ingestion of Anisakidae antigens contained in raw or cooked fish, and may masquerade as fish allergy.

In this study, we aim to characterize the relationship between Anisakidae and/or fish sensitization and the presence of allergic manifestations in patients recruited in the general population and presenting fish allergy resulting from ingestion, cutaneous or respiratory contact. We will also determine the respective role of Anisakidae or fish sensitization in patients with fish allergy. Then, we will determine the prevalence of previous Anisakidae infections among these patients and a matched control population. We will also compare the performances of serological tests (ImmunoCAP, immunoelectrophoresis and Western Blot) for the diagnosis of Anisakidae allergy or infection. Lastly, we will explore the relationship between domestic exposure to Anisakidae or fish antigens and the occurrence of associated pathologies (Anisakidae or fish allergy/sensitization; Anisakidae infection).


title: Prognostic Value of Recurrent Mutations in a Prospective Cohort of Myelodysplasia and Secondary Acute Myeloid Leukemias

summary: This study aims at prospectively enrolling a cohort of 400 incident cases of myelodysplastic syndromes (MDS) at diagnosis, to evaluate the impact of recurrent mutations on overall survival and event-free survival, using next generation sequencing. Patients are affected by ineffective hematopoiesis and a propensity to leukemia in the elderly with a global incidence of 10/100,000/year.

ReferenceCitation: Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Massé A, Kosmider O, Le Couedic JP, Robert F, Alberdi A, Lécluse Y, Plo I, Dreyfus FJ, Marzac C, Casadevall N, Lacombe C, Romana SP, Dessen P, Soulier J, Viguié F, Fontenay M, Vainchenker W, Bernard OA. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009 May 28;360(22):2289-301. doi: 10.1056/NEJMoa0810069.

family: Delhommeau

full_name: François Delhommeau

given: François

family: Dupont

full_name: Sabrina Dupont

given: Sabrina

family: Valle

full_name: Véronique Della Valle

given: Véronique Della

family: James

full_name: Chloé James

given: Chloé

family: Trannoy

full_name: Severine Trannoy

given: Severine

family: Massé

full_name: Aline Massé

given: Aline

family: Kosmider

full_name: Olivier Kosmider

given: Olivier

family: Le Couedic

full_name: Jean-Pierre Le Couedic

given: Jean-Pierre

family: Robert

full_name: Fabienne Robert

given: Fabienne

family: Alberdi

full_name: Antonio Alberdi

given: Antonio

family: Lécluse

full_name: Yann Lécluse

family: Plo

full_name: Isabelle Plo

given: Isabelle

family: Dreyfus

full_name: François J. Dreyfus

given: François J.

family: Marzac

full_name: Christophe Marzac

given: Christophe

family: Casadevall

full_name: Nicole Casadevall

given: Nicole

family: Lacombe

full_name: Catherine Lacombe

given: Catherine

family: Romana

full_name: Serge P. Romana

given: Serge P.

family: Dessen

full_name: Philippe Dessen

given: Philippe

family: Soulier

full_name: Jean Soulier

given: Jean

family: Viguié

full_name: Franck Viguié

given: Franck

family: Fontenay

full_name: Michaela Fontenay

given: Michaela

family: Vainchenker

full_name: William Vainchenker

given: William

family: Bernard

full_name: Olivier A. Bernard

given: Olivier A.

title: Mutation inTET2in Myeloid Cancers

ReferenceCitation: Kosmider O, Gelsi-Boyer V, Cheok M, Grabar S, Della-Valle V, Picard F, Viguié F, Quesnel B, Beyne-Rauzy O, Solary E, Vey N, Hunault-Berger M, Fenaux P, Mansat-De Mas V, Delabesse E, Guardiola P, Lacombe C, Vainchenker W, Preudhomme C, Dreyfus F, Bernard OA, Birnbaum D, Fontenay M; Groupe Francophone des Myélodysplasies. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood. 2009 Oct 8;114(15):3285-91. doi: 10.1182/blood-2009-04-215814. Epub 2009 Aug 7.

ReferenceCitation: Kosmider O, Gelsi-Boyer V, Ciudad M, Racoeur C, Jooste V, Vey N, Quesnel B, Fenaux P, Bastie JN, Beyne-Rauzy O, Stamatoulas A, Dreyfus F, Ifrah N, de Botton S, Vainchenker W, Bernard OA, Birnbaum D, Fontenay M, Solary E; Groupe Francophone des Myélodysplasies. TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica. 2009 Dec;94(12):1676-81. doi: 10.3324/haematol.2009.011205. Epub 2009 Oct 1.

ReferenceCitation: Nibourel O, Kosmider O, Cheok M, Boissel N, Renneville A, Philippe N, Dombret H, Dreyfus F, Quesnel B, Geffroy S, Quentin S, Roche-Lestienne C, Cayuela JM, Roumier C, Fenaux P, Vainchenker W, Bernard OA, Soulier J, Fontenay M, Preudhomme C. Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission. Blood. 2010 Aug 19;116(7):1132-5. doi: 10.1182/blood-2009-07-234484. Epub 2010 May 20.

ReferenceCitation: Itzykson R, Kosmider O, Cluzeau T, Mansat-De Mas V, Dreyfus F, Beyne-Rauzy O, Quesnel B, Vey N, Gelsi-Boyer V, Raynaud S, Preudhomme C, Adès L, Fenaux P, Fontenay M; Groupe Francophone des Myelodysplasies (GFM). Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia. 2011 Jul;25(7):1147-52. doi: 10.1038/leu.2011.71. Epub 2011 Apr 15.

name: on behalf of the Groupe Francophone des Myelodysplasies (GFM)

ReferenceCitation: Kosmider O, Delabesse E, de Mas VM, Cornillet-Lefebvre P, Blanchet O, Delmer A, Recher C, Raynaud S, Bouscary D, Viguié F, Lacombe C, Bernard OA, Ifrah N, Dreyfus F, Fontenay M; GOELAMS Investigators. TET2 mutations in secondary acute myeloid leukemias: a French retrospective study. Haematologica. 2011 Jul;96(7):1059-63. doi: 10.3324/haematol.2011.040840. Epub 2011 Apr 20.

ReferenceCitation: Quivoron C, Couronné L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, Do Cruzeiro M, Delhommeau F, Arnulf B, Stern MH, Godley L, Opolon P, Tilly H, Solary E, Duffourd Y, Dessen P, Merle-Beral H, Nguyen-Khac F, Fontenay M, Vainchenker W, Bastard C, Mercher T, Bernard OA. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell. 2011 Jul 12;20(1):25-38. doi: 10.1016/j.ccr.2011.06.003. Epub 2011 Jun 30.

ReferenceCitation: Kosmider O, Gelsi-Boyer V, Slama L, Dreyfus F, Beyne-Rauzy O, Quesnel B, Hunault-Berger M, Slama B, Vey N, Lacombe C, Solary E, Birnbaum D, Bernard OA, Fontenay M. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia. 2010 May;24(5):1094-6. doi: 10.1038/leu.2010.52. Epub 2010 Apr 8.

ReferenceCitation: Damm F, Thol F, Kosmider O, Kade S, Löffeld P, Dreyfus F, Stamatoullas-Bastard A, Tanguy-Schmidt A, Beyne-Rauzy O, de Botton S, Guerci-Bresler A, Göhring G, Schlegelberger B, Ganser A, Bernard OA, Fontenay M, Heuser M. SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications. Leukemia. 2012 May;26(5):1137-40. doi: 10.1038/leu.2011.321. Epub 2011 Nov 8.

ReferenceCitation: Damm F, Kosmider O, Gelsi-Boyer V, Renneville A, Carbuccia N, Hidalgo-Curtis C, Della Valle V, Couronné L, Scourzic L, Chesnais V, Guerci-Bresler A, Slama B, Beyne-Rauzy O, Schmidt-Tanguy A, Stamatoullas-Bastard A, Dreyfus F, Prébet T, de Botton S, Vey N, Morgan MA, Cross NC, Preudhomme C, Birnbaum D, Bernard OA, Fontenay M; Groupe Francophone des Myélodysplasies. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood. 2012 Apr 5;119(14):3211-8. doi: 10.1182/blood-2011-12-400994. Epub 2012 Feb 17.

ReferenceCitation: Frisan E, Vandekerckhove J, de Thonel A, Pierre-Eugène C, Sternberg A, Arlet JB, Floquet C, Gyan E, Kosmider O, Dreyfus F, Gabet AS, Courtois G, Vyas P, Ribeil JA, Zermati Y, Lacombe C, Mayeux P, Solary E, Garrido C, Hermine O, Fontenay M. Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes. Blood. 2012 Feb 9;119(6):1532-42. doi: 10.1182/blood-2011-03-343475. Epub 2011 Dec 12.

ReferenceCitation: Damm F, Chesnais V, Nagata Y, Yoshida K, Scourzic L, Okuno Y, Itzykson R, Sanada M, Shiraishi Y, Gelsi-Boyer V, Renneville A, Miyano S, Mori H, Shih LY, Park S, Dreyfus F, Guerci-Bresler A, Solary E, Rose C, Cheze S, Prébet T, Vey N, Legentil M, Duffourd Y, de Botton S, Preudhomme C, Birnbaum D, Bernard OA, Ogawa S, Fontenay M, Kosmider O. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood. 2013 Oct 31;122(18):3169-77. doi: 10.1182/blood-2012-11-469619. Epub 2013 Sep 18.

ReferenceCitation: Damm F, Fontenay M, Bernard OA. Point mutations in myelodysplastic syndromes. N Engl J Med. 2011 Sep 22;365(12):1154-5; author reply 155. doi: 10.1056/NEJMc1108665.

location_facility: Assistance publique-Hôpitaux de Paris, Hôpital Cochin


title: the Post Operative Pericardial Effusion (POPE) Treatment Study

summary: The aim of the sudy is to evaluate, through clinical, biological and transthoracic echocardiography follow up, the evolution of post operative (cardiac surgery) pericardial effusion and mostly to evaluate the efficiency of a non steroidal anti inflammatory (NSAID) drug (diclofenac)for this indication.

ReferenceCitation: Meurin P, Weber H, Renaud N, Larrazet F, Tabet JY, Demolis P, Ben Driss A. Evolution of the postoperative pericardial effusion after day 15: the problem of the late tamponade. Chest. 2004 Jun;125(6):2182-7.

ReferenceCitation: Meurin P, Tabet JY, Thabut G, Cristofini P, Farrokhi T, Fischbach M, Pierre B, Driss AB, Renaud N, Iliou MC, Weber H; French Society of Cardiology. Nonsteroidal anti-inflammatory drug treatment for postoperative pericardial effusion: a multicenter randomized, double-blind trial. Ann Intern Med. 2010 Feb 2;152(3):137-43. doi: 10.7326/0003-4819-152-3-201002020-00004.

family: Meurin

full_name: Philippe Meurin

journal_name: Annals of Internal Medicine

publisher: American College of Physicians

publisher_dissemination: American College of Physicians

publisher_group: American College of Physicians

publisher_normalized: American College of Physicians

title: Nonsteroidal Anti-inflammatory Drug Treatment for Postoperative Pericardial Effusion

lead_sponsor: French Cardiology Society

location_facility:
Hôpital Bligny
Les Grands Prés
Hôpital Broussais
Centre Hospitalier Chateau Lemoine
IRIS


title: Assessment of the Rehabilitation of Postural Imbalance After Chronic Right Supratensorial Stroke by Prismatic Adaptation: Multicentric Randomised Sham-controlled Trial

acronym: PEQUIE

summary:
Postural imbalance after stroke leads to limitations of activity and a worse autonomy. The postural imbalance is increased in right supratensorial stroke (RSS) compared to left supratensorial stroke. The evidences for the rehabilitation of postural imbalance are weak.

Likewise, disorders of spatial reference frames are increased in RSS. The postural imbalance is correlated with the disorders of spatial reference frames in RSS patients.

Prismatic adaptation (PA) is often used for the rehabilitation of unilateral spatial neglect after RSS. Several studies have demonstrated a peculiar expansion of sensorimotor after-effects to spatial cognition. An immediate effect of reduction in postural imbalance have been showed in acute RSS. Therefore, it is interested to investigate the immediate and delayed effects of PA on the postural balance and the spatial reference frames in chronic RSS to purpose a new therapeutic approach.

The hypothesis of the study is that PA would improve the postural balance (activity) of chronic RSS patients by a reduction in mediolateral postural asymmetry, resulting from a " bottom-up " action of PA on spatial reference frames.

primary_purpose: Other

ReferenceCitation: Hugues A, Guinet-Lacoste A, Bin S, Villeneuve L, Lunven M, Pérennou D, Giraux P, Foncelle A, Rossetti Y, Jacquin-Courtois S, Luauté J, Rode G. Effects of prismatic adaptation on balance and postural disorders in patients with chronic right stroke: protocol for a multicentre double-blind randomised sham-controlled trial. BMJ Open. 2021 Nov 24;11(11):e052086. doi: 10.1136/bmjopen-2021-052086.

family: Hugues

full_name: Aurélien Hugues

given: Aurélien

family: Guinet-Lacoste

full_name: Amandine Guinet-Lacoste

given: Amandine

family: Bin

full_name: Sylvie Bin

given: Sylvie

family: Villeneuve

full_name: Laurent Villeneuve

given: Laurent

family: Lunven

full_name: Marine Lunven

given: Marine

family: Pérennou

full_name: Dominic Pérennou

given: Dominic

family: Giraux

full_name: Pascal Giraux

given: Pascal

family: Foncelle

full_name: Alexandre Foncelle

given: Alexandre

family: Rossetti

full_name: Yves Rossetti

given: Yves

family: Jacquin-Courtois

full_name: Sophie Jacquin-Courtois

given: Sophie

family: Luauté

full_name: Jacques Luauté

given: Jacques

family: Rode

full_name: Gilles Rode

given: Gilles

oa_host_type: publisher

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

lead_sponsor: Hospices Civils de Lyon

location_facility: Hôpital Henry Gabrielle, service de médecine physique et réadaptation


title: A French Multi-centric Atrial Fibrillation Catheter Ablation Survey

acronym: FrenchAF

summary:
Atrial fibrillation is the most frequent sustained arrhythmia. Catheter ablation is a procedure that is currently used for the treatment of symptomatic atrial fibrillation patients.

We have organized a multi-centric national survey of catheter ablation of atrial fibrillation in order to have a feedback on the type of procedures being performed and the overall results (freedom of atrial fibrillation) over an average follow-up of 18 months.

lead_sponsor: Clinique Pasteur

intervention_type: Procedure


title: Impact of in Utero Exposure to Anti-integrase Antiretrovirals on the Newborn Immune System

acronym: RAGIIF

summary: The objective of the study is to evaluate at birth, the diversity of the T repertoire of newborns exposed in utero to anti-integrases in comparison with a control group of children exposed to other antiretroviral drugs.

lead_sponsor: Assistance Publique - Hôpitaux de Paris

location_facility:
AP-HP, Hôpital Cochin
AP-HP, Hôpital Necker
AP-HP, Hôpital de la Pitié Salpêtrière
AP-HP, Hôpital Louis Mourier
AP-HP, Hôpital Bichat-Claude Bernard


title: A Prospective, Multicentre Study Evaluating the Clinical Performance of the T.E.S.S Anatomic and Reverse Shoulder Prostheses

summary: This observational study intends to collect efficacy and safety data on TESS shoulder system

status: Terminated

lead_sponsor: Zimmer Biomet

location_facility: Clinique Chirurgicale Orthopédique A.D.R.


title: A Prospective, Multicentre Study Evaluating the Clinical Performance of the S.E.S Shoulder Prosthesis

summary: This observational study intends to collect efficacy and safety data on S.E.S shoulder system


title: Sacral Neuromodulation With InterStim® Therapy for Intractable Urinary Voiding Dysfunctions (SOUNDS):an Observational Study

acronym: SOUNDS

summary: The purpose of this study is to document the safety, the effectiveness, the continued performance at mid and long term, the morbidity and the percent of surgical revisions of the Interstim® therapy for up to 5 years in a representative sample of French centers under real-life conditions of use.

ReferenceCitation: Chartier-Kastler E, Normand LL, Ruffion A, Saussine C, Braguet R, Rabut B, Ragni E, Perrouin-Verbe MA, Pierrevelcin J, Rousseau T, Gamé X, Tanneau Y, Dargent F, Biardeau X, Graziana JP, Stoica G, Brassart E, Fourmarier M, Yaghi N, Capon G, Ferchaud J, Berrogain N, Peyrat L, Pecoux F, Bryckaert PE, Melotti A, Abouihia A, Keller DUJ, Cornu JN. Sacral Neuromodulation with the InterStim System for Overactive Bladder: 3-Year Results from the French Prospective, Multicenter, Observational SOUNDS Study. Eur Urol Focus. 2021 Jul 29. pii: S2405-4569(21)00179-6. doi: 10.1016/j.euf.2021.06.013. [Epub ahead of print]

family: Chartier-Kastler

full_name: Emmanuel Chartier-Kastler

given: Emmanuel

family: Normand

full_name: Loïc Le Normand

given: Loïc Le

family: Ruffion

full_name: Alain Ruffion

given: Alain

family: Saussine

full_name: Christian Saussine

given: Christian

family: Braguet

full_name: Raïssa Braguet

given: Raïssa

family: Rabut

full_name: Bertrand Rabut

given: Bertrand

family: Ragni

full_name: Evelyne Ragni

given: Evelyne

family: Perrouin-Verbe

full_name: Marie-Aimée Perrouin-Verbe

given: Marie-Aimée

family: Pierrevelcin

full_name: Jean Pierrevelcin

given: Jean

family: Rousseau

full_name: Thierry Rousseau

given: Thierry

family: Gamé

full_name: Xavier Gamé

given: Xavier

family: Tanneau

full_name: Yves Tanneau

family: Dargent

full_name: François Dargent

given: François

family: Biardeau

full_name: Xavier Biardeau

family: Graziana

full_name: Jean Pierre Graziana

given: Jean Pierre

family: Stoica

full_name: Gabriel Stoica

given: Gabriel

family: Brassart

full_name: Elena Brassart

given: Elena

family: Fourmarier

full_name: Marc Fourmarier

given: Marc

family: Yaghi

full_name: Najdat Yaghi

given: Najdat

family: Capon

full_name: Gregoire Capon

given: Gregoire

family: Ferchaud

full_name: Jérôme Ferchaud

given: Jérôme

family: Berrogain

full_name: Nathalie Berrogain

given: Nathalie

family: Peyrat

full_name: Laurence Peyrat

given: Laurence

ReferenceCitation: Chartier-Kastler E, Le Normand L, Ruffion A, Dargent F, Braguet R, Saussine C, Tanneau Y, Graziana JP, Ragni E, Rabut B, Rousseau T, Biardeau X, Gamé X, Pierrevelcin J, Brassart E, Fourmarier M, Stoica G, Berrogain N, Yaghi N, Pecoux F, Capon G, Ferchaud J, Peyrat L, Bryckaert PE, Karsenty G, Melotti A, Abouihia A, Keller DUJ, Cornu JN. Sacral Neuromodulation with the InterStim™ System for Intractable Lower Urinary Tract Dysfunctions (SOUNDS): Results of Clinical Effectiveness, Quality of Life, Patient-Reported Outcomes and Safety in a French Multicenter Observational Study. Eur Urol Focus. 2020 Sep 6. pii: S2405-4569(20)30212-1. doi: 10.1016/j.euf.2020.06.026. [Epub ahead of print]

location_facility: Maison des consultations - Centre Briochin d'Urologie

location_facility: CHU Bordeaux - Centre Universitaire Pellegrin

location_facility: Clinique Mutualiste de la porte de l'Orient

location_facility: Clinique Mutualiste de la Porte de lOrient

location_facility: Groupe Hospitalier Diaconesses Croix Saint-Simon


title: Expansion ex Vivo Des Cellules Tumorales Circulantes Comme modèle de Pharmacologie prédictive Des Cancers. EXPEVIVO-CTC

acronym: EXPEVIVO-CTC

summary:
Several studies conducted over the past decade have shown that Circulating tumor cells (CTCs) can be used as a marker for predicting disease progression and survival in patients with early or metastatic cancer. A high number of CTCs correlate with aggressive disease, increased metastasis and decreased survival rates.

Knowledge of metastasis mechanisms was mainly obtained from mouse models with CTCs after orthotopic transplants. The only possibility to study the patient's CTC subpopulations is to carry out ex-vivo expansion and develop an animal model with CTC xenograft. Because circulating blood collection is simple and non-invasive, CTCs can be used as a marker to track disease progression and survival in real time. CTCs could also guide therapeutic choice.


title: Cryotherapy and Doppler in Inflammatory Rheumatic Diseases

acronym: CDRI

summary:
The primary aim of the study is to evaluate the effects of two local cryotherapy (ice or cold gas) applications on arthritic knees.

Evaluation criteria (before/after treatment):

synovial power-Doppler semi-quantitative score
pain VAS (mm)
cytokine levels in synovial fluid
leukocyte count in synovial fluid

ReferenceType: result

ReferenceCitation: Guillot X, Tordi N, Mourot L, Demougeot C, Dugué B, Prati C, Wendling D. Cryotherapy in inflammatory rheumatic diseases: a systematic review. Expert Rev Clin Immunol. 2014 Feb;10(2):281-94. doi: 10.1586/1744666X.2014.870036. Epub 2013 Dec 18. Review.

family: Guillot

full_name: Xavier Guillot

family: Tordi

full_name: Nicolas Tordi

given: Nicolas

family: Mourot

full_name: Laurent Mourot

given: Laurent

family: Demougeot

full_name: Céline Demougeot

given: Céline

family: Dugué

full_name: Benoît Dugué

given: Benoît

family: Prati

full_name: Clément Prati

given: Clément

family: Wendling

full_name: Daniel Wendling

given: Daniel

journal_name: Expert Review of Clinical Immunology

ReferenceCitation: Guillot X, Tordi N, Prati C, Verhoeven F, Pazart L, Wendling D. Cryotherapy decreases synovial Doppler activity and pain in knee arthritis: A randomized-controlled trial. Joint Bone Spine. 2017 Jul;84(4):477-483. doi: 10.1016/j.jbspin.2016.09.004. Epub 2016 Nov 4.

family: Verhoeven

full_name: Frank Verhoeven

given: Frank

family: Pazart

full_name: Lionel Pazart

given: Lionel

journal_name: Joint Bone Spine

location_facility: Centre hospitalier universitaire de Besançon


title: Multicenter Prospective Pilot Study Investigating Pathophysiology, Diagnostic and Therapeutic Strategies of Hepatosplenic Candidiasis

acronym: CANHPARI

summary: The purpose of this study is to determine whether F18 fluorodeoxyglucose (18F-FDG) positron-emission tomography scan (PET scan) is useful for the therapy strategy of hepatosplenic candidiasis.

location_facility: Service des Maladies Infectieuses et Tropicales - Centre d'Infectiologie Necker-Pasteur, IHU Imagine - Hôpital Necker-Enfants Malades,


title: Telemonitoring in Pulmonary Rehabilitation: Feasibility and Acceptability of a Remote Pulse Oxymetry System (FA-TELE-REHAB)

summary:
Pulmonary rehabilitation effectively improves outcomes in patients with chronic respiratory disease, however there is a lack of pulmonary rehabilitation centers. Telehealth technology is one solution to deliver supervised home-based rehabilitation (tele-rehabilitation).

However, the feasibility and the acceptability of using telehealth technology to deliver tele-rehabilitation has not been assessed in a large scale multicenter study.

Therefore, the aim of this study is to assess the feasibility and the acceptability of telemonitoring system during pulmonary rehabilitation in patients with chronic respiratory disease.

ReferenceCitation: Bonnevie T, Gravier FE, Elkins M, Dupuis J, Prieur G, Combret Y, Viacroze C, Debeaumont D, Robleda-Quesada A, Quieffin J, Lamia B, Patout M, Cuvelier A, Muir JF, Medrinal C, Tardif C. People undertaking pulmonary rehabilitation are willing and able to provide accurate data via a remote pulse oximetry system: a multicentre observational study. J Physiother. 2019 Jan;65(1):28-36. doi: 10.1016/j.jphys.2018.11.002. Epub 2018 Dec 17.

apc_source: doaj

family: Bonnevie

full_name: Tristan Bonnevie

given: Tristan

family: Gravier

full_name: Francis-Edouard Gravier

given: Francis-Edouard

family: Elkins

full_name: Mark Elkins

given: Mark

family: Dupuis

full_name: Johan Dupuis

given: Johan

family: Prieur

full_name: Guillaume Prieur

given: Guillaume

family: Combret

full_name: Yann Combret

given: Yann

family: Viacroze

full_name: Catherine Viacroze

given: Catherine

family: Debeaumont

full_name: David Debeaumont

given: David

family: Robleda-Quesada

full_name: Aurora Robleda-Quesada

given: Aurora

family: Quieffin

full_name: Jean Quieffin

given: Jean

family: Lamia

full_name: Bouchra Lamia

given: Bouchra

family: Patout

full_name: Maxime Patout

given: Maxime

family: Cuvelier

full_name: Antoine Cuvelier

given: Antoine

family: Muir

full_name: Jean-François Muir

given: Jean-François

family: Medrinal

full_name: Clement Medrinal

given: Clement

family: Tardif

full_name: Catherine Tardif

currency_apc_doaj: EUR

journal_name: Journal of Physiotherapy

location_facility:
Groupe Hospitalier du Havre
ADIR Association


title: Prevalence and Consequences of Urinary Incontinence in People With Chronic Pulmonary Diseases Referred for Pulmonary Rehabilitation

acronym: PRECUI-PR

summary:
Urinary incontinence is a frequent chronic condition in general population. It is even more frequent in people with chronic respiratory disease due to several factors, including but not limited to frequent cough. Urinary incontinence may be more frequent during exercise so that it may contribute to the general deconditioning associated with chronic respiratory disease.

Although pulmonary rehabilitation is a cornerstone in the management of people with chronic respiratory disease to break this spiral of worsening dyspnea, little is known about the prevalence of urinary incontinence among those people referred for pulmonary rehabilitation nor about its impact on the effects of the program.


title: Effects of Pulmonary Rehabilitation on Cognitive Function in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease

summary:
Chronic obstructive pulmonary disease is a leading cause of mortality worldwide.

It is a systemic disease which includes pulmonary, cardiac, muscular, digestive and cognitive impairments.

Pulmonary rehabilitation is a symptomatic treatment to reduce dyspnea and functional incapacity. However, it effects on cognitive dysfunction are not well known.

The aim of this study is to assess the effects of a comprehensive pulmonary rehabilitation program on cognitive dysfunction in patients with severe to very severe chronic obstructive pulmonary disease using the Montreal Cognitive Assessment tool.

location_facility: Médrinal Bonnevie


title: Interest of Auriculotherapy in the Management of Chronic Insomnia

acronym: AURICULO-DODO

summary: The aim of the study is to show that auriculotherapy is effective in the treatment of chronic insomnia.

lead_sponsor: Hopital Foch

location_facility:
Espace Santé Simone Veil
Cabinet Médical Nouvelle France
Hopital Foch
Cabinet de l'Olivier