title: Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion

acronym: CONVASC-I

summary: Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.

location_facility: Service de Neuroradiologie interventionnelle - Hôpital Neurologique/Groupement Est

location_facility: Service de Neurologie vasculaire - Hôpital Neurologique/Groupement Est

location_facility: Service d'Anesthésie Réanimation - Hôpital Edouard Herriot/Groupement Centre

location_facility: Service d'Anesthésie Réanimation Hôpital - Neurologique/Groupement Est


title: An Open-label Study to Evaluate the Efficacy and Safety of add-on Memantine [5-10 mg b.i.d (10-20 mg/Day)] to Rivastigmine [1.5-6 mg b.i.d. (3-12 mg/Day)] Treatment in Patients With Alzheimer's Disease Who Continued With Rivastigmine Treatment After a Previous Decline While on Donepezil or Galantamine Treatment

summary: This is a prospective, multicenter, open-label study. Following screening and baseline assessments, eligible patients will be switched to rivastigmine and will enter the 16 week run-in rivastigmine treatment phase. After completion of assessments at the end of the run-in phase, patients who were not sufficiently stabilized on rivastigmine alone will receive add-on memantine to their rivastigmine treatment; patients who were stabilized on rivastigmine alone will have completed and be discontinued from the study.

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Non-Randomized

primary_purpose: Treatment

enrollment_type: Actual

lead_sponsor: Novartis

intervention_type: Drug

lead_sponsor_type: industriel

status_simplified: Completed


title: Can the Relative Fecal Abundance of BLSE and the Digestive Microbiota be Predictive of the Risk of Infection in a Carrier Patient?

summary:
Among Enterobacteriaceae, the production of beta-lactamases (ESBLs) is the leading cause of multi-resistance. The first cases of ESBL-producing Enterobacteriaceae (E-ESBL) infections were described in the 1980s and subsequently experienced worldwide dissemination.

Since the turn of the century, the prevalence of E-ESBL infections, especially among Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) has increased dramatically.

The emergence of multidrug-resistant Enterobacteriaceae is currently a real public health problem. The European Antimicrobial Resistance Surveillance Network evaluated, among clinical strains, the rate of resistance to 3rd generation cephalosporins (C3G) at 9.5% for E. coli and 28% for K. pneumoniae. Numerous studies have shown that bacterial colonization is the prerequisite for the occurrence of many infections.

However, the existence of prior colonization does not seem to be the only risk factor for the occurrence of a secondary infection. Therefore, in patients with multidrug-resistant Gram-negative bacillus gastrointestinal carriage there appear to be factors associated with the onset of infection. Several studies have examined the risk factors associated with E-ESBL-related infections in both community-based and healthcare-associated / nosocomial infections. Two main risk factors seem to be associated with E-ESBL infections: prior antibiotic therapy and the existence of invasive devices.

A recent study, carried out on 1288 patients and aimed at validating a predictive score for the occurrence of ESBL-E bacteremia, demonstrated 5 factors associated with the appearance of E-ESBL-linked bacteremia. These factors were: (i) a history of colonization / infection with ESBL-E, (ii) age ≥ 43 years, (iii) recent hospitalization in a region with a high prevalence of ESBL-E, (iv) antibiotic therapy ≥ 6 days in the previous 6 months and (v) the existence of a chronic vascular access.

Recently, a retrospective case-control study conducted in the United States by Augustine et al. Suggested that 5% of cases of bacteremia were related to ESBL-E.

Few studies have looked at risk factors for infection in patients known to be colonized by the digestive system. In a retrospective case-control study, conducted outside the intensive care unit and including pediatric and adult patients, the authors identified 2 factors associated with the occurrence of Ec-ESBL infection in previously colonized patients. These two factors were the prior use of antibiotics with β-lactam antibiotics and β-lactamase inhibitor (s), and urinary catheterization.

In intensive care hospital patients, the occurrence of ESBL-producing enterobacteriaceae infection appears to be a rare event, including in colonized patients.

The work of Ruppé et al. showed a direct link between relative fecal abundance of EScher-producing Escherichia coli and prior antibiotic intake.

This work also demonstrated a link between the value of the relative fecal abundance in Ec-ESBL and the occurrence of a urinary tract infection linked to the same clone. In particular, the authors found that women with a low relative fecal abundance rate (≤ 0.1%) had no risk of developing an Escherichia coli urinary tract infection. Conversely, the risk increased with the relative fecal abundance of Escherichia coli, but with a positive predictive value limited to 57% for relative fecal abundances between 10 and 100%.

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

primary_purpose: Diagnostic

enrollment_type: Anticipated

ReferenceType: result

ReferenceCitation: Wertheim HF, Vos MC, Ott A, van Belkum A, Voss A, Kluytmans JA, van Keulen PH, Vandenbroucke-Grauls CM, Meester MH, Verbrugh HA. Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet. 2004 Aug 21-27;364(9435):703-5.

ReferenceCitation: Bruyère R, Vigneron C, Bador J, Aho S, Toitot A, Quenot JP, Prin S, Charles PE. Significance of Prior Digestive Colonization With Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Patients With Ventilator-Associated Pneumonia. Crit Care Med. 2016 Apr;44(4):699-706. doi: 10.1097/CCM.0000000000001471.

family: Bruyère

full_name: Rémi Bruyère

given: Rémi

sequence: first

family: Vigneron

full_name: Clara Vigneron

given: Clara

sequence: additional

family: Bador

full_name: Julien Bador

given: Julien

family: Aho

full_name: Serge Aho

given: Serge

family: Toitot

full_name: Amaury Toitot

given: Amaury

family: Quenot

full_name: Jean-Pierre Quenot

given: Jean-Pierre

family: Prin

full_name: Sébastien Prin

given: Sébastien

family: Charles

full_name: Pierre Emmanuel Charles

given: Pierre Emmanuel

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Critical Care Medicine

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

title: Significance of Prior Digestive Colonization With Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Patients With Ventilator-Associated Pneumonia*

ReferenceCitation: Dubinsky-Pertzov B, Temkin E, Harbarth S, Fankhauser-Rodriguez C, Carevic B, Radovanovic I, Ris F, Kariv Y, Buchs NC, Schiffer E, Cohen Percia S, Nutman A, Fallach N, Klausner J, Carmeli Y; R-GNOSIS WP4 Study Group. Carriage of Extended-spectrum Beta-lactamase-producing Enterobacteriaceae and the Risk of Surgical Site Infection After Colorectal Surgery: A Prospective Cohort Study. Clin Infect Dis. 2019 May 2;68(10):1699-1704. doi: 10.1093/cid/ciy768.

name: National Institute for Antibiotic Resistance and Infection Control, Tel Aviv Sourasky Medical Center, Israel

name: Sackler Faculty of Medicine, Tel Aviv University, Israel

family: Dubinsky-Pertzov

full_name: Biana Dubinsky-Pertzov

given: Biana

family: Temkin

full_name: Elizabeth Temkin

given: Elizabeth

name: Infection Control Program, Geneva University Hospitals and Faculty of Medicine, WHO Collaborating Center, Switzerland

family: Harbarth

full_name: Stephan Harbarth

given: Stephan

family: Fankhauser-Rodriguez

full_name: Carolina Fankhauser-Rodriguez

given: Carolina

name: Department of Hospital Epidemiology, Clinical Center of Serbia, Belgrade

family: Carevic

full_name: Biljana Carevic

given: Biljana

family: Radovanovic

full_name: Ivana Radovanovic

given: Ivana

name: Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Switzerland

family: Ris

full_name: Frederic Ris

given: Frederic

name: Department of Surgery, Tel Aviv Sourasky Medical Center, Israel

family: Kariv

full_name: Yehuda Kariv

given: Yehuda

family: Buchs

full_name: Nicolas C Buchs

given: Nicolas C

name: Department of Anesthesiology, Geneva University Hospitals and Faculty of Medicine, Switzerland

family: Schiffer

full_name: Eduardo Schiffer

given: Eduardo

family: Cohen Percia

full_name: Shimrit Cohen Percia

given: Shimrit

family: Nutman

full_name: Amir Nutman

given: Amir

family: Fallach

full_name: Noga Fallach

title: Carriage of Extended-spectrum Beta-lactamase–producing Enterobacteriaceae and the Risk of Surgical Site Infection After Colorectal Surgery: A Prospective Cohort Study

ReferenceCitation: Zahar JR, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, Harbarth S, Timsit JF, Brun-Buisson C; BacterCom Study Group. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Int J Antimicrob Agents. 2017 Jan;49(1):67-73. doi: 10.1016/j.ijantimicag.2016.09.032. Epub 2016 Nov 16. Erratum in: Int J Antimicrob Agents. 2017 Apr;49(4):480-481.

journal_name: International Journal of Antimicrobial Agents

ReferenceCitation: Rodríguez-Baño J, Navarro MD, Retamar P, Picón E, Pascual Á; Extended-Spectrum Beta-Lactamases-Red Española de Investigación en Patología Infecciosa/Grupo de Estudio de Infección Hospitalaria Group. β-Lactam/β-lactam inhibitor combinations for the treatment of bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli: a post hoc analysis of prospective cohorts. Clin Infect Dis. 2012 Jan 15;54(2):167-74. doi: 10.1093/cid/cir790. Epub 2011 Nov 4.

name: the Extended-Spectrum Beta-Lactamases-Red Espanola de Investigacion en Patologia Infecciosa/Grupo de Estudio de Infeccion Hospitalaria Group

title: -Lactam/ -Lactam Inhibitor Combinations for the Treatment of Bacteremia Due to Extended-Spectrum -Lactamase-Producing Escherichia coli: A Post Hoc Analysis of Prospective Cohorts

ReferenceCitation: Goodman KE, Lessler J, Cosgrove SE, Harris AD, Lautenbach E, Han JH, Milstone AM, Massey CJ, Tamma PD; Antibacterial Resistance Leadership Group. A Clinical Decision Tree to Predict Whether a Bacteremic Patient Is Infected With an Extended-Spectrum β-Lactamase-Producing Organism. Clin Infect Dis. 2016 Oct 1;63(7):896-903. doi: 10.1093/cid/ciw425. Epub 2016 Jun 28.

title: A Clinical Decision Tree to Predict Whether a Bacteremic Patient Is Infected With an Extended-Spectrum β-Lactamase–Producing Organism

ReferenceCitation: Augustine MR, Testerman TL, Justo JA, Bookstaver PB, Kohn J, Albrecht H, Al-Hasan MN. Clinical Risk Score for Prediction of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Bloodstream Isolates. Infect Control Hosp Epidemiol. 2017 Mar;38(3):266-272. doi: 10.1017/ice.2016.292. Epub 2016 Dec 19.

journal_name: Infection Control & Hospital Epidemiology

title: Clinical Risk Score for Prediction of Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Bloodstream Isolates

location_facility:
Hôpital Necker-Enfants malades
Centre Hospitalier Sud-Francilien
Groupe Hospitalier Paris Saint-Joseph
Hôpital Avicenne


type: Other Identifier

title: Natural History Study of Usher Syndrome in a Cohort of Patients Followed Longitudinally for 5 Years

summary: Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the foreseen USH clinical trials. The clinical arm of the project aims at performing a deep-phenotyping of retinal degeneration, hearing loss, vestibular dysfunction, neurocognitive ability of subects with a molecular diagnosis of any Usher syndrome. Functional and structural parameters for retinal, auditory, and vestibular impairments are followed overtime to document the natural history of the disease and establish relevant clinical endpoint for disease progression that may be useful for future clinical trials.

study_type: Observational

time_perspective: Prospective

lead_sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

lead_sponsor_type: academique

status_simplified: Ongoing


title: Early Remote Intervention in Autism: a Randomized Noninferiority Clinical Trial Comparing Semi-intensive Early Start Denver Model (ESDM) Intervention With Remote Parental Training/ Supervision Versus Intensive ESDM Intervention.

acronym: IPAAD

summary:
The Early Start Denver Model (ESDM) has shown its efficiency in the early management of ASD.

The study aims to evaluate the efficiency of a new type of management based on a semi-intensive center-based intervention (8h per week) coupled with a MOOC (Massive Online Open Course: a teaching and learning intervention based on instrumental and interactive teaching situations) for remote parental training/supervision. The goal is to determine if compared to the ESDM reference intervention (15h per week), this type of care can bring, a sufficient improvement in child development course and decreased symptoms of autism in young children, and if it could be, therefore, better suited to the needs of children and their family, bypassing the previously stated obstacles.

study_start_date_type: Anticipated

status: Not yet recruiting

design_allocation: Randomized

primary_purpose: Other

lead_sponsor: University Hospital, Brest

location_facility:
CH Réné-Dubos
CHU Nantes
CH Limoges
CHU Le Havre

intervention_type: Other


title: ACE Trial :Not Worn-Out Aneurism of the Abdominal Aorta Under Renal " Surgery Versus Endoprosthesis "

acronym: ACE

summary:
Abdominal aortic aneurysm (AAA) is a life threatening disease. There is a consensus to propose surgical repair in patients with a reasonable operative risk when the AAA exceeds 5 cm in diameter.

The aim of the study is to compare the mortality and the occurrence of severe general, vascular and local complications in two groups of patients treated by either by open surgery or by EVAR (EndoVascular Aneurysm Repair). The main outcome criteria and the secondary endpoint are respectively the survival without severe complications and minor morbidity.

ReferenceType: background

ReferenceCitation: Lederle FA. Endovascular repair of abdominal aortic aneurysm--round two. N Engl J Med. 2005 Jun 9;352(23):2443-5.

ReferenceType: derived

ReferenceCitation: Becquemin JP, Pillet JC, Lescalie F, Sapoval M, Goueffic Y, Lermusiaux P, Steinmetz E, Marzelle J; ACE trialists. A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low- to moderate-risk patients. J Vasc Surg. 2011 May;53(5):1167-1173.e1. doi: 10.1016/j.jvs.2010.10.124. Epub 2011 Jan 26.

family: Becquemin

full_name: Jean-Pierre Becquemin

family: Pillet

full_name: Jean-Chistophe Pillet

given: Jean-Chistophe

family: Lescalie

full_name: François Lescalie

given: François

family: Sapoval

full_name: Marc Sapoval

given: Marc

family: Goueffic

full_name: Yann Goueffic

given: Yann

family: Lermusiaux

full_name: Patrick Lermusiaux

given: Patrick

family: Steinmetz

full_name: Eric Steinmetz

given: Eric

family: Marzelle

full_name: Jean Marzelle

given: Jean

journal_name: Journal of Vascular Surgery

oa_host_type: publisher

evidence: open (via crossref license)

host_type: publisher

license: elsevier-specific: oa user license

license_normalized: elsevier-specific

version: publishedVersion

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

lead_sponsor: Assistance Publique - Hôpitaux de Paris

intervention_type: Procedure


title: Efficacy and Safety of the Albumin Dialysis MARS® Therapy in Patients With Fulminant and Subfulminant Hepatic Failure

summary:
The purpose of this study is to improve the survival rate of those patients with acute fulminant hepatitis through treatment with the MARS® extra-corporal liver-purification system by:

Reducing the number of patients who die before a graft is available
Increasing the chances of survival without a liver transplant
Reducing the pre- and post-operative mortality in transplant patients

ReferenceCitation: Novelli G, Rossi M, Pretagostini R, Novelli L, Poli L, Ferretti G, Iappelli M, Berloco P, Cortesini R. A 3-year experience with Molecular Adsorbent Recirculating System (MARS): our results on 63 patients with hepatic failure and color Doppler US evaluation of cerebral perfusion. Liver Int. 2003;23 Suppl 3:10-5.

ReferenceCitation: Saliba F, Camus C, Durand F, Mathurin P, Letierce A, Delafosse B, Barange K, Perrigault PF, Belnard M, Ichaï P, Samuel D. Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial. Ann Intern Med. 2013 Oct 15;159(8):522-31. doi: 10.7326/0003-4819-159-8-201310150-00005.

family: Saliba

full_name: Faouzi Saliba

given: Faouzi

family: Camus

full_name: Christophe Camus

given: Christophe

family: Durand

full_name: François Durand

family: Mathurin

full_name: Philippe Mathurin

given: Philippe

family: Letierce

full_name: Alexia Letierce

given: Alexia

family: Delafosse

full_name: Bertrand Delafosse

given: Bertrand

family: Barange

full_name: Karl Barange

given: Karl

family: Perrigault

full_name: Pierre François Perrigault

given: Pierre François

family: Belnard

full_name: Magali Belnard

given: Magali

family: Ichaï

full_name: Philippe Ichaï

family: Samuel

full_name: Didier Samuel

given: Didier

journal_name: Annals of Internal Medicine

publisher: American College of Physicians

publisher_dissemination: American College of Physicians

publisher_group: American College of Physicians

publisher_normalized: American College of Physicians

title: Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure

intervention_type: Device


title: Evaluation Des Performances du Test Rapide antigénique Covid-19 Ag BSS Chez l'Enfant Symptomatique Dans un Service d'Urgences pédiatriques

summary: This study compares the diagnostic performance of a nasopharyngeal swab antigenic test versus the RT-PCR Covid-19 reference test performed with the AllplexTM 2019-nCoV kit (Seegene, South Korea) in symptomatic children presenting at the hospital.

lead_sponsor: Centre Hospitalier Intercommunal Creteil

location_facility: Centre hospitalier intercommunal de Créteil

intervention_type: Diagnostic Test


title: Effect of Iron-Chelating Therapy in Friedreich Ataxia. Study Phase I/II

summary: Friedreich ataxia, an autosomal recessive condition, ascribed to frataxin gene expansion, has been shown to result from an iron- induced injury to the mitochondrial respiratory chain. Buffering free radicals with short-chain quinones (Idebenone) protects the patients against cardiomyopathy but not CNS involvement. Removing CNS iron should limit the impact of the neurological symptoms of the disease.


title: Efficiency of Capsule Endoscopy and Push Enteroscopy in Obscure Gastrointestinal Bleeding. A Prospective Randomized Study.

summary: Capsule endoscopy (CE) is a safe and effective tool for the assessment of obscure gastrointestinal bleeding (OGIB). However, its real efficacy and its position in the diagnostic algorithm of OGIB vs. push enteroscopy (PE) remain unknown since in previous studies both techniques were performed in all included patients The purpose of this protocol is to conduct a randomized prospective controlled trial in patients with OGIB comparing a strategy based on CE or PE followed by the alternative exploration only when the first line exploration was negative. The main outpoint of this study concerns the diagnostic yield of the two explorations. Second endpoint concerns the clinical relevance of the two strategies tested (CE ± PE vs. CE ± PE) in terms of diagnostic yield, clinical outcome, therapeutic impact and added explorations

ReferenceCitation: Adler DG, Knipschield M, Gostout C. A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin. Gastrointest Endosc. 2004 Apr;59(4):492-8.


title: Randomised Prospective Comparison of the nonmyélo-Ablative Allograft and the Traditional Allograft in Acute Myeloid Leukaemia in Complete Remission of the Adult

summary: The allograft of marrow in its technique of reference (myélo-ablative (MA) condition by cyclophosphamide and total body irradiation (TBI) with strong amounts) therapeutic is recognized acute myeloid leukaemia (AML) of the adult for the patients of less than 55 years, because it offers chances of cure higher than chemotherapy or the auto-graft. However, mortality related to the traditional graft is approximately 30% to 1 year. The recent use of the non-myélo-ablative graft (NMA), in which the anti-leukaemia effect rests exclusively on the allogenic effect "graft-versus-leukaemia" makes it possible to obtain among patients of more than 55 years in complete reemission (CR), survivals without relapses comparable with the traditional allograft among patients of more than 35 years. The major interest of NMA graft is to reduce early mortality related to the graft. This reduction should be all the more significant as the patient is younger, and thus bring to a better survival. There is not, at the present hour, of prospective comparative study of the two procedures of graft. Taking into account the results observed after NMA graft among patients of more than 55 years, and taking into account the toxicity of the standard graft between 35 and 55 years, it is essential to now compare the 2 approaches among patients who do not have a counter-indication for one or the other, in the age bracket where the toxicity of the traditional graft is highest.

status: Unknown status

ReferenceCitation: Gratwohl A, Brand R, Frassoni F, Rocha V, Niederwieser D, Reusser P, Einsele H, Cordonnier C; Acute and Chronic Leukemia Working Parties; Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transplant. 2005 Nov;36(9):757-69.

status_simplified: Unknown


title: Early Detection of Prostate Cancer by Liquid Biopsy

acronym: PROLIPSY

summary:
This study is the early detection of prostate cancer by analysing circulating bloodbased biomarkers. Based on our latest developments, we primarily aim to assess the validity of CTCs (circulating tumour cells) and tumour cell products circulating in blood (DNA, exosomes) for early PCa (Prostate cancer) detection.

In the first discovery period, the investigators will assess which Liquid biopsy marker will provide the best discrimination between the patients with histologically proven PCa and age-matched noncancer controls. Further subset analysis with special emphasis on the identification of high risk PCa patients with aggressive tumours as defined by a Gleason score ("gold standard") of 8 or higher (ISUP 4 and higher), will be performed. The resulting biomarker candidates will then be further explored in the subsequent training and validation study (years 2 and 3) in order to obtain the single blood test or combination of tests with the highest sensitivity and specificity for detection of early PCa and/or high-risk PCa. The investigators will also compare these new biomarkers with recently FDA cleared CE-IVD assays for early detection of prostate cancer, based on classic peripheral tumour markers, such as Prostate Health Index (PHI) and PCA3. Follow up evaluations will be initiated to assess the prognostic relevance of the candidate biomarkers determined in this project. Here, the investigators will set up the data management system including all relevant information on the tissues collected and the results of the analyses as well as the clinical data of the patients investigated in this study.

ipd_sharing: No

lead_sponsor: University Hospital, Montpellier

location_facility: Clinique Beau Soleil - Service d'urologie

location_facility: CHU de Nîmes - Service Urologie Andrologie Sexologie

location_facility: CHU Montpellier - Département d'urologie et transplantation rénale

location_facility: CHU Montpellier - Laboratoire des Cellules Circulantes Rares Humaines


title: Prospective Study of the Influence of the Humidification Mode on Ventilation Parameters and Arterial Blood Gases in Non Invasive Ventilation

summary: To humidify gases during non invasive ventilation, both to heated humidifier (HH) and heat and moisture exchanger (HME) are routinely used. Patients receiving non invasive ventilation for acute respiratory failure were randomized to HME or HH. The purpose of this study was to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with small dead space HME compared to HH.

status: Terminated

lead_sponsor: University Hospital, Bordeaux

location_facility: Département de Réanimation Médicale, Hôpital Pellegrin-Tripode, Place A. Raba Léon,


title: Study of Ponderal Load in Parkinsonian Patients After Deep Brain Stimulation of the Subthalamic Nucleus

summary: The aim of this trial is to verify that neurostimulated parkinsonian patients gain weight and to study its link with an energetic balance change.

primary_purpose: Prevention

location_facility: Service de neurologie Hôpital Haut-Lévêque


title: PLASMACARD - Fresh Frozen Plasma in Cardiac Surgery: Descriptive and Prognostic Study

acronym: PLASMACARD

summary:
Despite experts' recommendations, the consumption of Fresh frozen plasma (FFP) is very heterogeneous among French cardiac surgery centers. This probably reflects heterogeneous practices that are not characterized and whose outcomes on morbidity and mortality are not documented.

The principal objective of the study is to describe transfusional strategies of FFP in patients undergoing cardiac surgery. The other objectives are: to assess the conformity of FFP transfusion or lack of transfusion to current French authorities' recommendations, to describe the post-operative mortality and morbidity and to assess the prognostic role of FFP on mortality and morbidity. Prognostic analyses will take into account other prognostic factors of mortality and morbidity.

1500 patients undergoing cardiac surgery and presenting with a serious bleeding (or transfused with FFP without bleeding) will be included in the study.

location_facility: Département d'anesthésie-réanimation II (DAR II), Hôpital Haut-Lévêque, Av de Magellan


title: Randomized, Multicenter Phase III Trial Comparing Adjuvant Treatment With PegIntron Over 36 Months Versus Reference Treatment With IntronA Over 18 Months in Cutaneous Melanoma Patients AJCC Stage II (>=1.5 mm Clinically Node Negative)

acronym: EADO

summary: Melanoma with a tumor thickness >= 1.5mm without clinically detectable nodes represents an increasing population with relapse rate of more than 50%. Adjuvant therapy with low doses of IFN alpha can provide a benefit in this group. However, the impact of low dose IFN alpha is not sustained after the treatment period. A longer treatment may prolong the benefit and thus have a more clear-cut impact on disease-free and overall survival. The tolerance and the impact on quality of life are limiting factors in a group of patients whose individual course is not necessarily poor. PegIntron may be better tolerated than instant release interferon, and thus make this treatment more acceptable in terms of toxicity and quality of life. Thus treatment schedule with PegIntron is not expected to increase the cost of standard care significantly.

ReferenceCitation: Grob JJ, Jouary T, Dréno B, Asselineau J, Gutzmer R, Hauschild A, Leccia MT, Landthaler M, Garbe C, Sassolas B, Herbst RA, Guillot B, Chene G, Pehamberger H. Adjuvant therapy with pegylated interferon alfa-2b (36 months) versus low-dose interferon alfa-2b (18 months) in melanoma patients without macrometastatic nodes: an open-label, randomised, phase 3 European Association for Dermato-Oncology (EADO) study. Eur J Cancer. 2013 Jan;49(1):166-74. doi: 10.1016/j.ejca.2012.07.018. Epub 2012 Sep 10.

family: Grob

full_name: Jean Jacques Grob

given: Jean Jacques

family: Jouary

full_name: Thomas Jouary

given: Thomas

family: Dréno

full_name: Brigitte Dréno

given: Brigitte

family: Asselineau

full_name: Julien Asselineau

given: Julien

family: Gutzmer

full_name: Ralf Gutzmer

given: Ralf

family: Hauschild

full_name: Axel Hauschild

given: Axel

family: Leccia

full_name: Marie Thérèse Leccia

given: Marie Thérèse

family: Landthaler

full_name: Michael Landthaler

given: Michael

family: Garbe

full_name: Claus Garbe

given: Claus

family: Sassolas

full_name: Bruno Sassolas

given: Bruno

family: Herbst

full_name: Rudolf A Herbst

given: Rudolf A

family: Guillot

full_name: Bernard Guillot

given: Bernard

family: Chene

full_name: Genevieve Chene

given: Genevieve

family: Pehamberger

full_name: Hubert Pehamberger

given: Hubert

journal_name: European Journal of Cancer

title: Adjuvant therapy with pegylated interferon alfa-2b (36months) versus low-dose interferon alfa-2b (18months) in melanoma patients without macrometastatic nodes: An open-label, randomised, phase 3 European Association for Dermato-Oncology (EADO) study


title: Efficacy of a Therapeutic Strategy in Peripheral Neuropathic Pain: Intravenous Sodium Valproate Followed by Oral Route Treatment Versus Placebo (Clinical and Neurophysiologic Evaluation)

summary: The purpose of this study is to determine whether valproate is effective and well tolerated in the treatment of neuropathic peripheral pain. The drug is administered by intravenous route followed by oral route during 4 weeks.

location_facility: Unité de traitement de la douleur chronique, Hôpital Pellegrin, CHU de Bordeaux


title: Randomized Placebo-Controlled Trial of a Triple Therapy Combining Peginterferon Alfa-2a Plus Ribavirin Plus Amantadine Versus Peginterferon Alfa-2a Plus Ribavirin Plus Placebo in Hepatitis C-Infected Patients Non Responders to a First-Line Therapy of Interferon and Ribavirin

acronym: PEGARI

summary: Response to a second-line anti-HCV treatment in non responder patients to a first-line dual therapy remains very poor. Preliminary studies of amantadine suggest that this drug could be potentially effective to treat hepatitis C.

location_facility: Service d'hépato-Gastro-Entérologie - Hôpital Haut Leveque - avenue de Magellan


title: Efficacy of Docetaxel (J 15) and Celecoxib in Metastatic Prostate Cancer

summary: Clinical response to chemotherapy. Biological parameter (PSA) and RECIST evaluation. Association of Docetaxel (J 15) and Celecoxib.

lead_sponsor: University Hospital, Rouen


title: Effect of Glutamine on Gastric Emptying and Length of Parenteral Nutrition in Premature Neonates

summary: This study investigates the effects of enterally supplied glutamine on gastric emptying, intestinal transit, age of total enteral nutrition and age at the end of hospitalisation. Forty neonates, aged at least 2 days and free of acute illness participate in a prospective, randomised, double-blind study. All are fed with parenteral and enteral nutrition enriched with glutamine (0.7 g/kg/per day, group 1) or isonitrogenous control (group 2). Gastric emptying is analysed by sequential measure of intragastric residue by diluted polyethylene glycol (PEG) 4000. Intestinal transit is analysed by Rouge Carmin test.

intervention_type: Dietary Supplement


title: Clinical Evaluation of Maintenance BCG Immunotherapy in Superficial Bladder Tumors

summary: Evaluation of maintenance BCG immunotherapy (dose 27 mg) in superficial bladder tumors. Two randomized arms (every 3 or 6 months) will be studied for a population of 300 patients.

intervention_type: Biological


title: Transcriptome Analysis Through a Dedicated Macro-array and TcLandscape Repertoire Analysis for Diagnosis of Myositis.

acronym: MYOARRAY

summary:
The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.

Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies.

Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.


title: Bilateral Laryngeal Paralysis Reinnervation. Speech and Ventilatory Results Analysis

summary: Bilateral laryngeal reinnervation induces a rise in laryngeal resistance and speech alteration. The aim of this study is to propose laryngeal reinnervation by a phrenic nerve root to patients with bilateral laryngeal paralysis.


title: Endoscopic Follow-up of Low Grade Precancerous Bronchial Lesions in High Risk Patients (SELEPREBB1)

summary:
The goal of this multicentric French randomized trial is to determine the best auto fluorescence bronchial endoscopic follow-up strategy in high risk patients bearing low grade bronchial precancerous lesions. Subjects will be randomly assigned to one of the following arm :

(A) every 6 months clinical and chest Xrays follow-up without intermediate endoscopy, (B) every 6 months clinical and chest Xrays follow-up including repeated autofluorescence endoscopy and biopsies on a 6 months basis in case of low grade dysplasia or on a one year basis in patients without dysplasia.

After 36 months follow-up, each patient from the two groups will be subjected to a final autofluorescence endoscopy and biopsy and a Spiral Chest Xray.

The final analysis will compare between the two groups :

The probability of progression from an initially identified low grade lesion to a high grade lesion
The probability of respiratory epithelial tract progression assessed by the occurrence of a lung cancer or high grade lesion.
The characteristics of lung cancers detected in each arm
In both arm, the influence of risk factors and persistent exposure to tobacco on lesion evolutivity.

ReferenceCitation: Thiberville L, Moreno-Swirc S, Vercauteren T, Peltier E, Cavé C, Bourg Heckly G. In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy. Am J Respir Crit Care Med. 2007 Jan 1;175(1):22-31. Epub 2006 Oct 5.

ReferenceCitation: Salaün M, Roussel F, Bourg-Heckly G, Vever-Bizet C, Dominique S, Genevois A, Jounieaux V, Zalcman G, Bergot E, Vergnon JM, Thiberville L. In vivo probe-based confocal laser endomicroscopy in amiodarone-related pneumonia. Eur Respir J. 2013 Dec;42(6):1646-58. doi: 10.1183/09031936.00191911. Epub 2012 Sep 27.

family: Salaün

full_name: Mathieu Salaün

given: Mathieu

family: Roussel

full_name: Francis Roussel

given: Francis

family: Bourg-Heckly

full_name: Geneviève Bourg-Heckly

given: Geneviève

family: Vever-Bizet

full_name: Christine Vever-Bizet

given: Christine

family: Dominique

full_name: Stéphane Dominique

given: Stéphane

family: Genevois

full_name: Anne Genevois

given: Anne

family: Jounieaux

full_name: Vincent Jounieaux

given: Vincent

family: Zalcman

full_name: Gérard Zalcman

given: Gérard

family: Bergot

full_name: Emmanuel Bergot

given: Emmanuel

family: Vergnon

full_name: Jean-Michel Vergnon

given: Jean-Michel

family: Thiberville

full_name: Luc Thiberville

given: Luc

journal_name: European Respiratory Journal

evidence: open (via free pdf)

license_normalized: no license

publisher: European Respiratory Society (ERS)

publisher_dissemination: European Respiratory Society

publisher_group: European Respiratory Society

publisher_normalized: European Respiratory Society

title: In vivoprobe-based confocal laser endomicroscopy in amiodarone-related pneumonia


title: Evaluation of the Efficacy and Tolerance of 2 Dosages of Type A Botulinic Toxin in Neurogenic Areactive Bladder Resistant to Oral Medical Treatment

summary: The purpose of this study is to determine the efficacy and tolerance of 2 dosages (750 versus 500 units) of the Dysport type A botulinic toxin for patient suffering from neurogenic urinary incontinence by an overactive bladder and the failure of anticholinergic drugs.

ReferenceCitation: Grise P, Ruffion A, Denys P, Egon G, Chartier Kastler E. Efficacy and tolerability of botulinum toxin type A in patients with neurogenic detrusor overactivity and without concomitant anticholinergic therapy: comparison of two doses. Eur Urol. 2010 Nov;58(5):759-66. doi: 10.1016/j.eururo.2010.06.035. Epub 2010 Jul 3.

family: Grise

full_name: Philippe Grise

given: Philippe

family: Ruffion

full_name: Alain Ruffion

given: Alain

family: Denys

full_name: Pierre Denys

given: Pierre

family: Egon

full_name: Guy Egon

given: Guy

family: Chartier Kastler

full_name: Emmanuel Chartier Kastler

journal_name: European Urology

title: Efficacy and Tolerability of Botulinum Toxin Type A in Patients with Neurogenic Detrusor Overactivity and Without Concomitant Anticholinergic Therapy: Comparison of Two Doses


title: Gene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid Arthritis

summary:
The objective of the study is to identify and validate predictive markers of infliximab responsiveness in RA patients by 2 approaches: i) measuring biochemical, immunological and bone markers in sera because of their involvement in pathogenic mechanisms; ii) identifying gene-expression signatures in PBMCs by the transcriptomic analysis.

Patients with active RA (ACR criteria) were given i.v. 3 mg/kg infliximab associated with metotrexate at weeks 0, 2, 6, and every 8th week. Infliximab efficacy was evaluated at week 14, using the EULAR response criteria.

Just before the starting of infliximab treatment, the following parameters were measured in the sera: i) immunological tests: rheumatoid factor (IgA, IgG, IgM), anti-CCP, autoAb recognizing the 27 C-terminal fragment (ACAST-C27) and domain I (ACAST-DI) of calpastatin, anti-G6PI, anti a-enolase, anti-keratin and anti-perinuclear factor; ii) biochemical markers: CRP, MMP-1, MMP-3, TIMP-1, TIMP-2; markers of bone resorption: pyridinolin, deoxypyridinolin, osteoprotegerin, sRANKL, COMP. The predictive value of each parameter for a response/non-response to infliximab was analysed using Fischer's exact, Mann-Whitney and Chi2 tests.
A blood sample was collected just before the onset of infliximab treatment and total RNAs were extracted from the peripheral blood mononuclear cells. The [33P] radiolabeled mRNAs were hybridized (duplicate or triplicate) over a set of 10.000 human cDNA probes spotted at a high density on nylon membranes. Data were normalized and filtered to allow the comparison between RNA samples. Statistical analyses were performed with the R software and hierarchical clustering was performed with the Cluster and Tree View softwares.


title: Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans

summary:
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated.

Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.

ReferenceCitation: Goichon A, Coëffier M, Claeyssens S, Lecleire S, Cailleux AF, Bôle-Feysot C, Chan P, Donnadieu N, Lerebours E, Lavoinne A, Boyer O, Vaudry D, Déchelotte P. Effects of an enteral glucose supply on protein synthesis, proteolytic pathways, and proteome in human duodenal mucosa. Am J Clin Nutr. 2011 Sep;94(3):784-94. doi: 10.3945/ajcn.110.009738. Epub 2011 Jul 27.

family: Goichon

full_name: A. Goichon

given: A.

family: Coeffier

full_name: M. Coeffier

given: M.

family: Claeyssens

full_name: S. Claeyssens

given: S.

family: Lecleire

full_name: S. Lecleire

family: Cailleux

full_name: A.-F. Cailleux

family: Bole-Feysot

full_name: C. Bole-Feysot

given: C.

family: Chan

full_name: P. Chan

given: P.

family: Donnadieu

full_name: N. Donnadieu

given: N.

family: Lerebours

full_name: E. Lerebours

given: E.

family: Lavoinne

full_name: A. Lavoinne

family: Boyer

full_name: O. Boyer

given: O.

family: Vaudry

full_name: D. Vaudry

given: D.

family: Dechelotte

full_name: P. Dechelotte

journal_name: American Journal of Clinical Nutrition

publisher: Oxford University Press (OUP)

publisher_dissemination: Oxford University Press

publisher_group: Oxford University Press

publisher_normalized: Oxford University Press


title: Gene Expression Profiling in PBMCs as a Tool for Prediction of Anakinra Responsiveness in Rheumatoid Arthritis

summary:
The objective of the study is to identify and validate predictive markers of anakinra responsiveness in RA patients by a transcriptomic approach.

Patients with active RA (ACR criteria) were given subcutaneous anakinra (100mg/d) 3 associated with metotrexate. Anakinra efficacy was evaluated at week 12, using the EULAR response criteria.

A blood sample was collected just before the onset of anakinra treatment and total RNAs were extracted from the peripheral blood mononuclear cells. The [33P] radiolabeled mRNAs were hybridized (duplicate or triplicate) over a set of 10.000 human cDNA probes spotted at a high density on nylon membranes. Data were normalized and filtered to allow the comparison between RNA samples. Statistical analyses were performed with the R software and hierarchical clustering was performed with the Cluster and Tree View softwares.

ReferenceCitation: Bansard C, Lequerré T, Derambure C, Vittecoq O, Hiron M, Daragon A, Pouplin S, Daveau M, Boyer O, Tron F, Le Loët X, Salier JP. Gene profiling predicts rheumatoid arthritis responsiveness to IL-1Ra (anakinra). Rheumatology (Oxford). 2011 Feb;50(2):283-92. doi: 10.1093/rheumatology/keq344. Epub 2010 Nov 8.

family: Bansard

full_name: C. Bansard

family: Lequerre

full_name: T. Lequerre

given: T.

family: Derambure

full_name: C. Derambure

family: Vittecoq

full_name: O. Vittecoq

family: Hiron

full_name: M. Hiron

family: Daragon

full_name: A. Daragon

family: Pouplin

full_name: S. Pouplin

family: Daveau

full_name: M. Daveau

family: Tron

full_name: F. Tron

given: F.

family: Le Loet

full_name: X. Le Loet

given: X.

family: Salier

full_name: J.-P. Salier

journal_name: Rheumatology


title: Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Healthy Controls

summary:
Scleroderma is an autoimmune disease of unknown origin. Recently, the role of environmental factors, and particularly toxic drug exposure, in the genesis of scleroderma has been suggested.

This prompted us to conduct this prospective, case-control, multicentric study, including 2 groups of subjects:

100 patients with scleroderma
300 sex- and age-matched healthy controls. The aim of our study is to determine whether exposure to toxics is higher in patients with scleroderma compared with healthy controls.


title: Traitment of Patients Presenting Pemphigus With Anti CD20 (Mabthera).

summary: to treat in an open non comparative clinical study patients presenting pemphigus with corticodependance, corticoresistance and contre-indication to systemic steroids.

primary_purpose: Health Services Research

ReferenceCitation: Joly P, Mouquet H, Roujeau JC, D'Incan M, Gilbert D, Jacquot S, Gougeon ML, Bedane C, Muller R, Dreno B, Doutre MS, Delaporte E, Pauwels C, Franck N, Caux F, Picard C, Tancrede-Bohin E, Bernard P, Tron F, Hertl M, Musette P. A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med. 2007 Aug 9;357(6):545-52.


title: Weekly Cisplatin/Irinotecan and Radiotherapy in Patients With Locally Advanced Esophageal Cancer: Phase II Trial

summary: The standard non surgical therapy of locally advanced esophageal cancer is based on a definitive concurrent chemoradiotherapy regimen with fluorouracil and cisplatin. One of the alternative regimen which is being studied is the combination of a weekly cisplatin and irinotecan schedule with radiotherapy. This multicentric phase II clinical trial primarily aimed to evaluate the clinical complete response rate and secondary objectives were toxicity profile and survival.


title: Predictive Elements of Trauma and Its After-effects: Importance of the Quality of Neurobiological Response to Stress

acronym: LIFT-UP

summary:
The neurobiological response to stress is an adaptive response allowing us to cope with the multiple aggressions of daily life. This response orchestrates the body's systemic reaction. The intensity of response to stress can modify the body's functioning, which implies a variety of fields where biomarkers may be isolated: immunity, psychology, neurophysiology, integrative physiology. When stress is too intense or prolonged, response to stress may become misfitted and deleterious.

This study is based on the hypothesis that a severe physical or psychological trauma is associated with an intense and misfitted stress that is responsible from an undue immuno-inflammatory activation (through sympathetic activation). The result is a subinvasive state of systemic and tissue inflammation (low-noise inflammation), responsible for the mid-term deleterious consequences of the traumatic event.

The objective of this study is to understand how the dysregulation of intense stress simultaneously generates an initial pathological state and an alteration of mid-term evolution (which is considered as a poor prognosis and/or as responsible for after-effects).

The investigators wish to identify relevant biomarkers of the mechanisms activated during intense stress and influencing the immuno-inflammatory and epigenetic spheres with deleterious consequences on physiological and psychological functions.

ipd_sharing: Undecided

lead_sponsor: Direction Centrale du Service de Santé des Armées

location_facility: Hôpital d'Instruction des Armées Sainte-Anne


lead_sponsor: Centre Hospitalier Universitaire de Saint Etienne

acronym: PREAVIS

location_facility: Groupement Hospitalier des Portes de Province

type: EudraCT Number

source: euctr

title: Evaluation of the Pharmacokinetics and Pharmacodynamics of Hydroxychloroquine in COVID-19 Intensive Care Unit Patients

summary: To date, no treatment has demonstrated clinical efficacy on COVID 19. However, several therapeutic strategies are being considered and are being evaluated in numerous clinical trials. Among these strategies, the use of hydroxychloroquine (HCQ) seems promising. There is very little information on how to precisely administer hydroxychloroquine to patients infected with SARS-CoV-2 in intensive care, which may be responsible for side effects, some of which are potentially serious. In addition, this treatment has a long half-life which increases the risk of accumulation and therefore toxicity. In view of the lack of knowledge on the pharmacokinetic / pharmacodynamic properties of hydroxychloroquine in intensive care patients infected with SARS-CoV-2, we propose to perform a prospective multicenter cohort study in order to collect the biological data necessary for this evaluation.


status: Withdrawn

acronym: COV-ENOX

location_facility: Groupement Hospitalier des portes de Province

title: Evaluation of the Concentration-effect Relationship of Enoxaparin for Thromboembolic Prevention in COVID-19 Intensive Unit Care Patients.

summary:
Patients with COVID-19 have special demographic characteristics including thromboembolic risk factors .

The pharmacokinetics of enoxaparin administered subcutaneously in the intensive care unit patient are not described.

Finally, given the lack of knowledge on the pharmacokinetic/pharmacodynamic properties of enoxaparin in intensive care unit patients infected with SARS-CoV-2, we propose to conduct a prospective multicenter cohort study to collect the biological data necessary for its study.


title: Anger and Psychotrauma: Data From Military and Civilians

acronym: COPMiCiv

summary:
Post-Traumatic Stress Disorder (PTSD) is mainly associated with several emotions such as anger, guilt or shame. By interfering with psychotherapeutic work these emotions can be problematic. When suffering from PTSD, pervasive anger can also have relational consequences. Anger and PTSD are mutually reinforcing: anger can aggravate PTSD symptoms and aggressive behaviours, and conversely, PTSD promotes high levels of anger and aggression. A few explanatory hypotheses have been proposed. In terms of personality factors, anger-treatment may promote the severity of PTSD symptoms and the development of aggressive behaviours. In terms of stressors, exposure to combat and combat-related moral harms could play a role in the relationship between PTSD, anger and traumatic experiences over the course of life. Finally, in clinical terms, in the presence of PTSD, anger and aggressive behaviours may be triggered by substance abuse and depression.

Within the Anglo-Saxon literature, it is recognized that both civilians and military personnel with PTSD exhibit high levels of anger, with a possible predominance among military personnel. While we know that anger management mechanisms can be strongly influenced by cultural aspects and the type of event, there is no data in the French population.

This study proposes to fill in our knowledge of anger-PSTD relationships in the French population and by comparing civilian and military population.

location_facility: Centre Hospitalier Léon-Jean Grégory de Thuir

intervention_type: Behavioral


title: Characterization of T Cell Response in Hypersensitivity Syndrome

summary: immunological study of the T cell repertoire phenotype and functionality in hypersensitivity syndrome.

ReferenceCitation: Picard D, Janela B, Descamps V, D'Incan M, Courville P, Jacquot S, Rogez S, Mardivirin L, Moins-Teisserenc H, Toubert A, Benichou J, Joly P, Musette P. Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med. 2010 Aug 25;2(46):46ra62. doi: 10.1126/scitranslmed.3001116.

name: INSERM U905, Rouen University Hospital, Rouen 76000, France.

name: Department of Dermatology, Rouen University Hospital, Rouen 76000, France.

family: Picard

full_name: Damien Picard

given: Damien

family: Janela

full_name: Baptiste Janela

given: Baptiste

name: Department of Dermatology, Bichat University Hospital, Paris 75018, France.

family: Descamps

full_name: Vincent Descamps

given: Vincent

name: Department of Dermatology, Clermont-Ferrand University Hospital, Clermont-Ferrand 63003, France.

family: D’Incan

full_name: Michel D’Incan

given: Michel

name: Department of Pathology, Rouen University Hospital, Rouen 76000, France.

family: Courville

full_name: Philippe Courville

family: Jacquot

full_name: Serge Jacquot

given: Serge

name: Department of Virology, Limoges University Hospital, Limoges 87042, France.

family: Rogez

full_name: Sylvie Rogez

given: Sylvie

family: Mardivirin

full_name: Laurent Mardivirin

given: Laurent

name: INSERM U662, Saint-Louis Hospital, Paris 75010, France.

family: Moins-Teisserenc

full_name: Hélène Moins-Teisserenc

given: Hélène

family: Toubert

full_name: Antoine Toubert

given: Antoine

name: INSERM U657, Department of Biostatistics, Rouen University Hospital, Rouen 76000, France.

family: Benichou

full_name: Jacques Benichou

given: Jacques

family: Joly

full_name: Pascal Joly

given: Pascal

family: Musette

full_name: Philippe Musette

journal_name: Science Translational Medicine

publisher: American Association for the Advancement of Science (AAAS)

title: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Multiorgan Antiviral T Cell Response


title: Prospective Evaluation of Mandibular Advancement by Herbst Device in the Treatment of Moderate Obstructive Sleep Apnea Syndrome

summary: The purpose of this study is to determine if the mandibular advancement by Herbst device is effective in the treatment of moderate obstructive sleep apnea patients.


summary: to compare efficacity and tolerance of two stratégies of dermoval application in treatment of bullous pemphigus.


title: Health Professional Exposure Assessment to Covid-19

acronym: SERODRON

summary: Understanding the SARS-Cov2 epidemic is a major public health issue, both in the community and in the hospital sector. Because of their central position in the management of patients infected with COVID-19, hospital staff may be considered at high risk of infection. The development of serological tests makes it possible to reliably document a contamination, symptomatic or not, that is more than 3 weeks old. These tests, combined with clinical questioning of the symptoms, make it possible to determine the proportion of asymptomatic infections whose impact in the transmission of this disease appears to be major. The duration of the presence of the antibodies that are hoped to neutralize after infection with CoV2-SARS remains uncertain. Documenting the evolution of antibody levels and their monitoring in a population at high risk of re-exposure to CoV2-SARS is a major issue in understanding this disease and in assessing the risk of infection among healthcare workers.

status: Active, not recruiting

lead_sponsor: Tourcoing Hospital

location_facility:
CH Tourcoing
CH Roubaix
CH Wasquehal
CH Wattrelos


title: Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children

acronym: HEART-COVID

summary: The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or inadequate host response risk.

time_perspective: Retrospective

ReferenceCitation: Borgel D, Chocron R, Grimaud M, Philippe A, Chareyre J, Brakta C, Lasne D, Bonnet D, Toubiana J, Angoulvant F, Desvages M, Renolleau S, Smadja DM, Oualha M. Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome in Children With Shock. Crit Care Med. 2021 Nov 1;49(11):e1151-e1156. doi: 10.1097/CCM.0000000000005093.

family: Borgel

full_name: Delphine Borgel

given: Delphine

family: Chocron

full_name: Richard Chocron

given: Richard

family: Grimaud

full_name: Marion Grimaud

given: Marion

family: Philippe

full_name: Aurélien Philippe

given: Aurélien

family: Chareyre

full_name: Judith Chareyre

given: Judith

family: Brakta

full_name: Charlyne Brakta

given: Charlyne

family: Lasne

full_name: Dominique Lasne

given: Dominique

family: Bonnet

full_name: Damien Bonnet

family: Toubiana

full_name: Julie Toubiana

given: Julie

family: Angoulvant

full_name: François Angoulvant

given: François

family: Desvages

full_name: Maximilien Desvages

given: Maximilien

family: Renolleau

full_name: Sylvain Renolleau

given: Sylvain

family: Smadja

full_name: David M. Smadja

given: David M.

family: Oualha

full_name: Mehdi Oualha

given: Mehdi

oa_colors: green other

oa_host_type: publisher;repository

evidence: open (via free article)

evidence: oa repository (via pmcid lookup)

host_type: repository

repository_normalized: PubMed Central

title: Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2–Related Multisystem Inflammatory Syndrome in Children With Shock

location_facility:
Hôpital Necker-Enfants Malades
Hôpital Armand Trousseau
Hôpital Robert Debré
Hôpital Bicêtre


title: Cerebral Activity During Rectal Pain in Patients With Irritable Bowel Syndrome or Inflammatory Bowel Disease:Resonance Magnetic Imaging Study.

summary: Irritable bowel syndrome is responsible for chronic abdominal pain, diarrhea and/or constipation. It is a very frequent problem. However, the exact cause of irritable bowel syndrome remains unknown. The purpose of this study is to look for a different cerebral response by magnetic resonance imaging after rectal stimulation in patients with irritable bowel syndrome compared to healthy subjects and to patients with digestive organic disease. Our hypothesis is that irritable bowel syndrome could be a problem of cerebral integration of visceral stimulation.


title: Radiofrequency of Breast Cancers : Pilot Study in Non Surgical Patients

acronym: RF SEIN

summary: To treat breast tumors in non surgical patients with percutaneous technique (radiofrequency). Prospective evaluation of treatment efficiency and tolerance based on clinical and radiological evaluation

lead_sponsor: Institut Bergonié

location_facility: Institut Bergonié - Centre Régional de Luttre Contre le Cancer de Bordeaux et du Sud Ouest


title: Efficiency of Trans-cutanéous Electrical Nerve Stimulation for Isolated Primary Enuresis : A Randomised Controlled Trial

acronym: TENS-Enuresis

summary:
Nocturnal enuresis is a functional urinary disorder in children. It is intermittent urinary incontinence during sleep in children aged 5 years and older. It is said to be "primary" if the child has never been clean at night for at least 6 months and "isolated" if there are no other associated urinary symptoms, including daytime symptoms.

It is a common condition with significant repercussions, including disruption of family and social life and a frequent decline in self-esteem. Without treatment, it can persist into adulthood. All these reasons justify taking care of these children.

This is usually based on:

The establishment of hygienic-dietetic rules: Regular urination and before sleeping, limitation of fluid intake in the evening. They are systematically implemented, whatever the subsequent management Drug treatments (Desmopressin, oxybutynin). These treatments have an efficiency of 60 to 70% at 6 months post treatment and sometimes have side effects.

Non-drug treatments: Night-time "pee stop" alarms. They have an efficiency of around 70%. They are little used because they often wake up the whole family and are not reimbursed by social security.

TENS (Transcutaneous Electro Neuro Stimulation) is a neuro-modulation technique which consists of stimulating the nerves by means of skin electrodes in order to obtain a somatic response.

In urology, it is mainly used by stimulating either the sacral region, origin of the vesical innervation, or the tibial nerve. Its main indication is overactive bladder, a source of discomfort and incontinence.

It is used at home, the side effects are exceptional and it does not disturb the activities of the patients.

Few studies have evaluated its effectiveness in isolated primary enuresis.

lead_sponsor: Fondation Lenval

location_facility:
CH de Cannes
CH de GRASSE
Hôpitaux Pédiatrique de Nice CHU Lenval
CHU de Nice


title: COVID-19: Prospective Follow-up of Pulmonary Function, Sleep Disorders, Quality of Life and Post-traumatic Stress

acronym: Co-SURVIVORS

summary: The current project is a prospective, multicentric cohort study aiming at a multidisciplinary assessment (pulmonary, cardiometabolic, sleep and mental health) of the consequences of infection by SARS-CoV-2, 3 months after the diagnosis in order to better characterize these complications. 400 patients with a positive diagnosis of SARS-CoV-2 will be included in the study 3 months after their diagnosis: They will be followed at 6 months, 1 year, 3 years, and 5 years, as function of their after-effects discovered at 3 months and their evolution.

ReferenceCitation: Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585. Erratum in: JAMA. 2021 Mar 16;325(11):1113.

name: Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Wang

full_name: Dawei Wang

given: Dawei

family: Hu

full_name: Bo Hu

given: Bo

full_name: Chang Hu

given: Chang

family: Zhu

full_name: Fangfang Zhu

given: Fangfang

family: Liu

full_name: Xing Liu

given: Xing

family: Zhang

full_name: Jing Zhang

given: Jing

full_name: Binbin Wang

given: Binbin

family: Xiang

full_name: Hui Xiang

given: Hui

name: Department of Pulmonary Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Cheng

full_name: Zhenshun Cheng

given: Zhenshun

name: Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Xiong

full_name: Yong Xiong

given: Yong

name: Department of Emergency Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Zhao

full_name: Yan Zhao

given: Yan

name: Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

family: Li

full_name: Yirong Li

given: Yirong

name: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

full_name: Xinghuan Wang

given: Xinghuan

family: Peng

full_name: Zhiyong Peng

given: Zhiyong

journal_name: JAMA

evidence: oa repository (via OAI-PMH doi match)

repository_institution: PubMed Central - Europe PMC

publisher: American Medical Association (AMA)

publisher_dissemination: American Medical Association

publisher_group: American Medical Association

publisher_normalized: American Medical Association

title: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

ReferenceCitation: Hui DS, Joynt GM, Wong KT, Gomersall CD, Li TS, Antonio G, Ko FW, Chan MC, Chan DP, Tong MW, Rainer TH, Ahuja AT, Cockram CS, Sung JJ. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax. 2005 May;60(5):401-9.

ReferenceCitation: Burnham EL, Hyzy RC, Paine R 3rd, Coley C 2nd, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb;41(2):445-56. doi: 10.1097/CCM.0b013e31826a5062.

ReferenceCitation: Herridge MS, Moss M, Hough CL, Hopkins RO, Rice TW, Bienvenu OJ, Azoulay E. Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med. 2016 May;42(5):725-738. doi: 10.1007/s00134-016-4321-8. Epub 2016 Mar 30. Review.

ReferenceCitation: Luyt CE, Combes A, Becquemin MH, Beigelman-Aubry C, Hatem S, Brun AL, Zraik N, Carrat F, Grenier PA, Richard JM, Mercat A, Brochard L, Brun-Buisson C, Chastre J; REVA Study Group. Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS. Chest. 2012 Sep;142(3):583-592. doi: 10.1378/chest.11-2196.

family: Luyt

full_name: Charles-Edouard Luyt

given: Charles-Edouard

family: Combes

full_name: Alain Combes

title: Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

location_facility:
Centre Hospitalier Henri Mondor, APHP
Hôpital Avicenne
CHU Grenoble Alpes
CHRU Nancy


title: Collateral Damage From the COVID-19 Pandemic Observed in Patients Treated With Intravitreal Injections (IVT) of Anti-angiogenic Agents

acronym: COVIDIV

summary:
In patients treated for exudative age-related macular degeneration (AMD), diabetes, retinal venous occlusion (OVR), or other conditions causing macular edema, treatments with anti-angiogenic intravitreal injections (IVT) are widely used both for their anti-angiogenic action. Patients often have injections for many years, sometimes monthly or every 2 months.

The discontinuation of treatment with repeated injections of anti-angiogenic agents, linked to the COVID-19 coronavirus pandemic will potentially impact the visual acuity, the ophthalmological state and the quality of life of the patients concerned, therefore it is relevant to analyze the consequences the breakdown of usual care in this population.

lead_sponsor: Fondation Ophtalmologique Adolphe de Rothschild

location_facility:
Fondation Adolphe de Rothschild
Centre ophtalmologique Maison Rouge
Centre Pôle Vision du val d'Ouest
Hôpital Lariboisière


title: A Phase II Randomized Study to Compare Skin Late Toxicities of Concomitant Letrozole-Radiotherapy and Radiotherapy Followed by Letrozole as Adjuvant Therapy for Postmenopausal Women With Receptor (ER and/or PgR) Positive Tumors

summary: This trial will compare grade 2 or greater late skin toxicities of concomitant letrozole-radiotherapy and radiotherapy followed by letrozole as adjuvant therapy for postmenopausal women with receptor (estrogen receptor [ER] and/or progesterone receptor [PgR]) positive tumors. Each drug will be prescribed for 5 years.

ReferenceCitation: Azria D, Pelegrin A, Dubois JB, Mirimanoff RO, Ozsahin M. Radiation therapy and tamoxifen: concurrent or sequential? It's no longer the question! J Clin Oncol. 2005 Jun 20;23(18):4239-41; author reply 4241-2.

ReferenceCitation: Azria D, Larbouret C, Cunat S, Ozsahin M, Gourgou S, Martineau P, Evans DB, Romieu G, Pujol P, Pèlegrin A. Letrozole sensitizes breast cancer cells to ionizing radiation. Breast Cancer Res. 2005;7(1):R156-63. Epub 2004 Dec 7.

ReferenceCitation: Azria D, Gourgou S, Sozzi WJ, Zouhair A, Mirimanoff RO, Kramar A, Lemanski C, Dubois JB, Romieu G, Pelegrin A, Ozsahin M. Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients. Br J Cancer. 2004 Oct 4;91(7):1251-60.

ReferenceCitation: Azria D, Lemanski C, Zouhair A, Gutowski M, Belkacémi Y, Dubois JB, Romieu G, Ozsahin M. [Adjuvant treatment of breast cancer by concomitant hormonotherapy and radiotherapy: state of the art]. Cancer Radiother. 2004 Jun;8(3):188-96. Review. French.

ReferenceCitation: Bourgier C, Kerns S, Gourgou S, Lemanski C, Gutowski M, Fenoglietto P, Romieu G, Crompton N, Lacombe J, Pèlegrin A, Ozsahin M, Rosenstein B, Azria D. Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial. Ann Oncol. 2016 Mar;27(3):474-80. doi: 10.1093/annonc/mdv602. Epub 2015 Dec 17.

family: Bourgier

full_name: C. Bourgier

given: C.

family: Kerns

full_name: S. Kerns

given: S.

family: Gourgou

full_name: S. Gourgou

family: Lemanski

full_name: C. Lemanski

family: Gutowski

full_name: M. Gutowski

given: M.

family: Fenoglietto

full_name: P. Fenoglietto

given: P.

family: Romieu

full_name: G. Romieu

given: G.

family: Crompton

full_name: N. Crompton

given: N.

family: Lacombe

full_name: J. Lacombe

given: J.

family: Pèlegrin

full_name: A. Pèlegrin

given: A.

family: Ozsahin

full_name: M. Ozsahin

family: Rosenstein

full_name: B. Rosenstein

given: B.

family: Azria

full_name: D. Azria

given: D.

journal_name: Annals of Oncology

oa_colors: green hybrid

ReferenceCitation: Azria D, Belkacemi Y, Romieu G, Gourgou S, Gutowski M, Zaman K, Moscardo CL, Lemanski C, Coelho M, Rosenstein B, Fenoglietto P, Crompton NE, Ozsahin M. Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial. Lancet Oncol. 2010 Mar;11(3):258-65. doi: 10.1016/S1470-2045(10)70013-9. Epub 2010 Feb 6.

full_name: David Azria

given: David

family: Belkacemi

full_name: Yazid Belkacemi

given: Yazid

lead_sponsor: Institut du Cancer de Montpellier - Val d'Aurelle


title: Randomized Phase II Trial Followed by Phase III Trial With Molecular Biology Study, Comparing a Standard Bi-therapy vs 3 Arms of Intensified Chemotherapy in Patients With Unresectable or Not Optimally Resectable Colorectal Cancer Liver Metastases.

summary: Randomized, open label, multicentre phase II trial followed by phase III comparing overall survival after having selected the best experimental arm.


title: Evaluation of the Effects of Long Term Non-Invasive Ventilation in Patient With Cystic Fibrosis and Chronic Hypercapnic Respiratory Failure.

summary: There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.

ReferenceCitation: Ellaffi M, Vinsonneau C, Coste J, Hubert D, Burgel PR, Dhainaut JF, Dusser D. One-year outcome after severe pulmonary exacerbation in adults with cystic fibrosis. Am J Respir Crit Care Med. 2005 Jan 15;171(2):158-64. Epub 2004 Oct 22.

ReferenceCitation: Moran F, Bradley J. Non-invasive ventilation for cystic fibrosis. Cochrane Database Syst Rev. 2003;(2):CD002769. Review. Update in: Cochrane Database Syst Rev. 2007;(4):CD002769.

lead_sponsor: Cochin Hospital

location_facility: Department of pulmonary disease of Cochin Hospital (AP-HP)


title: Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness Associated With Chemoreflex Failure

summary: This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex. This reflex determines hyperventilation when the pressure of oxygen falls in the blood. This happens when subjects travel to high-altitude where oxygen levels diminish in the atmosphere. Subjects with such an altered chemoreflex are intolerant to altitude and develop pulmonary or cerebral edema associated with a severe headache. In this study we compare subjects tolerant to high altitude (8000 meters)to subjects intolerant to altitude. The chemoreflex is measured i.e. the hyperventilation associated with hypoxia and all subjects are scanned for the genes implicated in the mitochondrial respiratory chain. The idea is that subjects with an impaired oxygen sensing will exhibit an altered chemoreflex and will be intolerant to high-altitude.

ReferenceCitation: Gimenez-Roqueplo AP, Favier J, Rustin P, Rieubland C, Crespin M, Nau V, Khau Van Kien P, Corvol P, Plouin PF, Jeunemaitre X; COMETE Network. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res. 2003 Sep 1;63(17):5615-21.

ReferenceCitation: Gimenez-Roqueplo AP, Favier J, Rustin P, Rieubland C, Kerlan V, Plouin PF, Rötig A, Jeunemaitre X. Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma. J Clin Endocrinol Metab. 2002 Oct;87(10):4771-4.

ReferenceCitation: Gimenez-Roqueplo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, Corvol P, Rötig A, Jeunemaitre X. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet. 2001 Dec;69(6):1186-97. Epub 2001 Oct 16.

lead_sponsor: Société Française de Cardiologie

location_facility: Centre d'Investigation Clinique, Hopital Pompidou


title: Efficacy of 15 mg and 50 mg of S18986 on Cognitive Symptoms in Mild Cognitive Impairment Patients Treated Over a 12-month Oral Administration Period

summary: The purpose of this study is to demonstrate a long term efficacy of S18986 versus placebo on episodic memory performance in patients with MCI

ipd_sharing: Yes

ipd_sharing_description:
Researchers can ask for a study protocol, patient-level and/or study-level clinical trial data including clinical study reports (CSRs).

They can ask all interventional clinical studies:

submitted for new medicines and new indications approved after 1 January 2014 in the European Economic Area (EEA) or the United States (US).
Where Servier or an affiliate are the Marketing Authorization Holders (MAH). The date of the first Marketing Authorization of the new medicine (or the new indication) in one of the EEA Member States will be considered within this scope.

lead_sponsor: Institut de Recherches Internationales Servier


title: Evaluation of an Early Support Programme in Orthophony : the PAPEV-ortho Study

acronym: PAPEV-ortho

summary: Prospective, interventionnal with minimal risks and constraints, multicentric, non-randomized, open study, to measure the impact of an early support programme in speech and language therapy for vulnerable children (PAPEV-ortho), in children born very prematurely or very hypotrophically, on the incidence of language and communication deficits at the corrected age of 2 years.

ReferenceCitation: Pierrat V, Marchand-Martin L, Arnaud C, Kaminski M, Resche-Rigon M, Lebeaux C, Bodeau-Livinec F, Morgan AS, Goffinet F, Marret S, Ancel PY; EPIPAGE-2 writing group. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study. BMJ. 2017 Aug 16;358:j3448. doi: 10.1136/bmj.j3448.

family: Pierrat

full_name: Véronique Pierrat

given: Véronique

family: Marchand-Martin

full_name: Laetitia Marchand-Martin

given: Laetitia

family: Arnaud

full_name: Catherine Arnaud

given: Catherine

family: Kaminski

full_name: Monique Kaminski

given: Monique

family: Resche-Rigon

full_name: Matthieu Resche-Rigon

given: Matthieu

family: Lebeaux

full_name: Cécile Lebeaux

given: Cécile

family: Bodeau-Livinec

full_name: Florence Bodeau-Livinec

given: Florence

family: Morgan

full_name: Andrei S Morgan

given: Andrei S

family: Goffinet

full_name: François Goffinet

given: François

family: Marret

full_name: Stéphane Marret

given: Stéphane

family: Ancel

full_name: Pierre-Yves Ancel

given: Pierre-Yves

journal_name: BMJ

evidence: open (via page says license)

license: cc-by-nc

license_normalized: cc-by-nc

repository_institution: Université de Lille (University Of Lille) - LillOA

repository_normalized: LillOA (Lille Open Archive)

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

repository_normalized: HAL

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Grenoble Ecole de Management

repository_institution: University of Oxford - Oxford Academic Notes & Queries

repositories:
HAL
LillOA (Lille Open Archive)
PubMed Central
open-archive.highwire.org

title: Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study

ReferenceCitation: Nishimura T, Takei N, Tsuchiya KJ, Asano R, Mori N. Identification of neurodevelopmental trajectories in infancy and of risk factors affecting deviant development: a longitudinal birth cohort study. Int J Epidemiol. 2016 Apr;45(2):543-53. doi: 10.1093/ije/dyv363. Epub 2016 Feb 13.

ReferenceCitation: Sansavini A, Guarini A, Savini S, Broccoli S, Justice L, Alessandroni R, Faldella G. Longitudinal trajectories of gestural and linguistic abilities in very preterm infants in the second year of life. Neuropsychologia. 2011 Nov;49(13):3677-88. doi: 10.1016/j.neuropsychologia.2011.09.023. Epub 2011 Sep 21.

ReferenceCitation: van Noort-van der Spek IL, Franken MC, Weisglas-Kuperus N. Language functions in preterm-born children: a systematic review and meta-analysis. Pediatrics. 2012 Apr;129(4):745-54. doi: 10.1542/peds.2011-1728. Epub 2012 Mar 19. Review.

title: Language Functions in Preterm-Born Children: A Systematic Review and Meta-analysis

ReferenceCitation: Marchman VA, Fernald A. Speed of word recognition and vocabulary knowledge in infancy predict cognitive and language outcomes in later childhood. Dev Sci. 2008 May;11(3):F9-16. doi: 10.1111/j.1467-7687.2008.00671.x.

ReferenceCitation: Stolt S, Lind A, Matomäki J, Haataja L, Lapinleimu H, Lehtonen L. Do the early development of gestures and receptive and expressive language predict language skills at 5;0 in prematurely born very-low-birth-weight children? J Commun Disord. 2016 May-Jun;61:16-28. doi: 10.1016/j.jcomdis.2016.03.002. Epub 2016 Mar 9.

repository_normalized: HELDA - Digital Repository of the University of Helsinki

ReferenceCitation: Marchman VA, Loi EC, Adams KA, Ashland M, Fernald A, Feldman HM. Speed of Language Comprehension at 18 Months Old Predicts School-Relevant Outcomes at 54 Months Old in Children Born Preterm. J Dev Behav Pediatr. 2018 Apr;39(3):246-253. doi: 10.1097/DBP.0000000000000541.

journal_name: Journal of Developmental & Behavioral Pediatrics

ReferenceCitation: Boyer J, Flamant C, Boussicault G, Berlie I, Gascoin G, Branger B, N'Guyen The Tich S, Rozé JC. Characterizing early detection of language difficulties in children born preterm. Early Hum Dev. 2014 Jun;90(6):281-6. doi: 10.1016/j.earlhumdev.2014.03.005. Epub 2014 Apr 13.

ReferenceCitation: Sanchez K, Spittle AJ, Slattery JM, Morgan AT. Oromotor Feeding in Children Born Before 30 Weeks' Gestation and Term-Born Peers at 12 Months' Corrected Age. J Pediatr. 2016 Nov;178:113-118.e1. doi: 10.1016/j.jpeds.2016.07.044. Epub 2016 Sep 5.

ReferenceCitation: Telford EJ, Fletcher-Watson S, Gillespie-Smith K, Pataky R, Sparrow S, Murray IC, O'Hare A, Boardman JP. Preterm birth is associated with atypical social orienting in infancy detected using eye tracking. J Child Psychol Psychiatry. 2016 Jul;57(7):861-8. doi: 10.1111/jcpp.12546. Epub 2016 Mar 2.

name: MRC/Centre for Reproductive Health University of Edinburgh Edinburgh UK

name: Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

name: Department of Child Life and Health University of Edinburgh Edinburgh UK

name: Salvesen Mindroom Centre University of Edinburgh Edinburgh UK

journal_name: Journal of Child Psychology and Psychiatry

repository_institution: University of Edinburgh - Edinburgh Research Explorer

ReferenceCitation: Eeles AL, Anderson PJ, Brown NC, Lee KJ, Boyd RN, Spittle AJ, Doyle LW. Sensory profiles obtained from parental reports correlate with independent assessments of development in very preterm children at 2 years of age. Early Hum Dev. 2013 Dec;89(12):1075-80. doi: 10.1016/j.earlhumdev.2013.07.027. Epub 2013 Aug 24.

title: Sensory profiles obtained from parental reports correlate with independent assessments of development in very preterm children at 2years of age

ReferenceCitation: Zuccarini M, Guarini A, Savini S, Iverson JM, Aureli T, Alessandroni R, Faldella G, Sansavini A. Object exploration in extremely preterm infants between 6 and 9 months and relation to cognitive and language development at 24 months. Res Dev Disabil. 2017 Sep;68:140-152. doi: 10.1016/j.ridd.2017.06.002. Epub 2017 Aug 3.

ReferenceCitation: Charkaluk ML, Truffert P, Fily A, Ancel PY, Pierrat V; Epipage study group. Neurodevelopment of children born very preterm and free of severe disabilities: the Nord-Pas de Calais Epipage cohort study. Acta Paediatr. 2010 May;99(5):684-9. doi: 10.1111/j.1651-2227.2010.01695.x.

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Toulouse - Jean Jaurès

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Archive ouverte HAL

ReferenceCitation: Crunelle D, Le Normand MT, Delfosse MJ. [Oral and written language production in prematures children: results in 7 1/2-year-old]. Folia Phoniatr Logop. 2003 May-Jun;55(3):115-27. French.

ReferenceCitation: Forcada-Guex M, Pierrehumbert B, Borghini A, Moessinger A, Muller-Nix C. Early dyadic patterns of mother-infant interactions and outcomes of prematurity at 18 months. Pediatrics. 2006 Jul;118(1):e107-14.

ReferenceCitation: Spittle A, Orton J, Anderson PJ, Boyd R, Doyle LW. Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants. Cochrane Database Syst Rev. 2015 Nov 24;(11):CD005495. doi: 10.1002/14651858.CD005495.pub4. Review.

name: Murdoch Childrens Research Institute and the University of Melbourne; VIBeS Office, 5th Floor Flemington Road Parkville Melbourne Australia 3052

name: Royal Women's Hospital; 2nd Floor, Flemington Road Parkville Melbourne Australia 3052

name: Murdoch Childrens Research Institute, Royal Children’s Hospital; Department of Clinical Sciences; Flemington Road Melbourne Victoria Australia 3052

name: University of Queensland; Brisbane Queensland Australia

name: The University of Melbourne; Department of Obstetrics and Gynaecology; Parkville Victoria Australia 3052

location_facility:
Centre Hospitalier Louis Mourier
Centre Hospitalier Rives de Seine
Centre Hospitalier Sud Francilien
Hôpital Antoine Béclère


title: Prophylaxis of Thrombosis With Implantable Devices for Central Venous Access in Cancer Patients : Phase III Randomised Study

summary:
This is a Phase III open-labed, multicenter, prospective, randomised study, and comparative 3-arms of 140 patients (i.e. 420 total patients).

Study period (date of first inclusion/last inclusion): 3 years Treatment period : 3 months

ReferenceCitation: Lavau-Denes S, Lacroix P, Maubon A, Preux PM, Genet D, Vénat-Bouvet L, Labourey JL, Martin J, Slaouti P, Tubiana-Mathieu N. Prophylaxis of catheter-related deep vein thrombosis in cancer patients with low-dose warfarin, low molecular weight heparin, or control: a randomized, controlled, phase III study. Cancer Chemother Pharmacol. 2013 Jul;72(1):65-73. doi: 10.1007/s00280-013-2169-y. Epub 2013 May 1.

family: Lavau-Denes

full_name: Sandrine Lavau-Denes

given: Sandrine

family: Lacroix

full_name: P. Lacroix

given: P.

family: Maubon

full_name: A. Maubon

family: Preux

full_name: P. M. Preux

given: P. M.

family: Genet

full_name: D. Genet

family: Vénat-Bouvet

full_name: L. Vénat-Bouvet

given: L.

family: Labourey

full_name: J. L. Labourey

given: J. L.

family: Martin

full_name: J. Martin

given: J.

family: Slaouti

full_name: P. Slaouti

family: Tubiana-Mathieu

full_name: N. Tubiana-Mathieu

given: N.

journal_name: Cancer Chemotherapy and Pharmacology

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer

publisher_group: Springer

publisher_normalized: Springer

lead_sponsor: University Hospital, Limoges


title: A 4-Week Dose-Finding, Multicentre, Double-Blind, Randomised, Placebo-Controlled, Parallel-Group Trial to Assess the Efficacy and Safety of Different Doses of Rupatadine Compared to Placebo in the Treatment of Chronic Idiopathic Urticaria

summary: The objective of this study is to evaluate the efficacy and safety of rupatadine for the treatment of CIU symptoms.To assess the clinical efficacy of a dose ranging of rupatadine fumarate (5mg, 10mg, and 20 mg) compared with placebo for relief of CIU symptoms.

lead_sponsor: J. Uriach and Company


title: Three Modalities of Treatment in Operable and Resectable Stage IIIA (T1-3, N2) NSCLC. Randomized Phase II Study

summary: Stage IIIA non-small cell lung cancers comprising a mediastinal ganglionic invasion N2 account for 20 to 30% of the NSCLCs. They are almost always potentially resectable, but the results obtained by surgery alone or surgery followed by chemotherapy (CT) and/or radiotherapy (RT) are insufficient. The neoadjuvant approach was tested, in randomized tests of exclusive CT, or in noncomparative tests of RT-CT.

ReferenceCitation: Girard N, Mornex F, Douillard JY, Bossard N, Quoix E, Beckendorf V, Grunenwald D, Amour E, Milleron B. Is neoadjuvant chemoradiotherapy a feasible strategy for stage IIIA-N2 non-small cell lung cancer? Mature results of the randomized IFCT-0101 phase II trial. Lung Cancer. 2010 Jul;69(1):86-93. doi: 10.1016/j.lungcan.2009.10.003. Epub 2009 Oct 29.

family: Girard

full_name: Nicolas Girard

given: Nicolas

family: Mornex

full_name: Françoise Mornex

given: Françoise

family: Douillard

full_name: Jean-Yves Douillard

given: Jean-Yves

family: Bossard

full_name: Nadine Bossard

given: Nadine

family: Quoix

full_name: Elisabeth Quoix

given: Elisabeth

family: Beckendorf

full_name: Véronique Beckendorf

given: Véronique

family: Grunenwald

full_name: Dominique Grunenwald

given: Dominique

family: Amour

full_name: Elodie Amour

given: Elodie

family: Milleron

full_name: Bernard Milleron

given: Bernard

journal_name: Lung Cancer

lead_sponsor: Hospices Civils de Lyon

location_facility: Centre Hospitalier Lyon-Sud - Radiotherapie/Oncologie


title: Pilot Study of Addition of IL-2 to Pegylated Interferon Alpha 2a and Ribavirin for the Treatment of Chronic Hepatitis C in HIV-HCV Coinfected Patients Non Responders to Three Months of Therapy With Pegylated Interferon Alpha 2a and Ribavirin. ANRS HC09 SECOIIA

summary: The purpose of this pilot study is to evaluate efficacy and safety of addition of IL-2 to pegylated interferon alpha 2a and ribavirin in HIV-HCV coinfected patients non-responders after three months of standard therapy with pegylated interferon alpha 2a and ribavirin. IL-2 may enhance numbers and function of CD4 T lymphocytes and specific anti-HCV immune responses and could participate to the control of HCV replication

lead_sponsor: French National Agency for Research on AIDS and Viral Hepatitis


title: Induction of Labor or Waiting for Suspicion Fetal Macrosomia (DAME)

summary: Aim of the study :The major aim is to evaluate the effectiveness of the induction of labor in case of fetal macrosomia on the reduction of neonatal traumatism risk. The secondary aims are to evaluate maternal morbidity and the risk of Caesarean in case of induction of labor, compared to a spontaneous labor.

ReferenceCitation: Boulvain M, Senat MV, Perrotin F, Winer N, Beucher G, Subtil D, Bretelle F, Azria E, Hejaiej D, Vendittelli F, Capelle M, Langer B, Matis R, Connan L, Gillard P, Kirkpatrick C, Ceysens G, Faron G, Irion O, Rozenberg P; Groupe de Recherche en Obstétrique et Gynécologie (GROG). Induction of labour versus expectant management for large-for-date fetuses: a randomised controlled trial. Lancet. 2015 Jun 27;385(9987):2600-5. doi: 10.1016/S0140-6736(14)61904-8. Epub 2015 Apr 8.

family: Boulvain

full_name: Michel Boulvain

given: Michel

family: Senat

full_name: Marie-Victoire Senat

given: Marie-Victoire

family: Perrotin

full_name: Franck Perrotin

given: Franck

family: Winer

full_name: Norbert Winer

given: Norbert

family: Beucher

full_name: Gael Beucher

given: Gael

family: Subtil

full_name: Damien Subtil

given: Damien

family: Bretelle

full_name: Florence Bretelle

given: Florence

family: Azria

full_name: Elie Azria

given: Elie

family: Hejaiej

full_name: Dominique Hejaiej

family: Vendittelli

full_name: Françoise Vendittelli

family: Capelle

full_name: Marianne Capelle

given: Marianne

family: Langer

full_name: Bruno Langer

given: Bruno

family: Matis

full_name: Richard Matis

given: Richard

family: Connan

full_name: Laure Connan

given: Laure

family: Gillard

full_name: Philippe Gillard

given: Philippe

family: Kirkpatrick

full_name: Christine Kirkpatrick

given: Christine

family: Ceysens

full_name: Gilles Ceysens

given: Gilles

family: Faron

full_name: Gilles Faron

family: Irion

full_name: Olivier Irion

given: Olivier

family: Rozenberg

full_name: Patrick Rozenberg

given: Patrick

journal_name: The Lancet

oa_host_type: repository

repository_institution: The Pennsylvania State University - CiteSeer X

repository_normalized: CiteSeerX


title: Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery

acronym: STRATAGEM

summary: The STRATAGEM trial is an investigator-driven French nationwide multicenter, randomized, double-blind, placebo-controlled trial comparing perioperative low-dose aspirin therapy versus placebo in the perioperative period in patients with documented symptomatic stable atherothrombotic disease taking antiplatelet therapy and undergoing non-coronary surgery.

ReferenceCitation: Mantz J, Samama CM, Tubach F, Devereaux PJ, Collet JP, Albaladejo P, Cholley B, Nizard R, Barré J, Piriou V, Poirier N, Mignon A, Schlumberger S, Longrois D, Aubrun F, Farèse ME, Ravaud P, Steg PG; Stratagem Study Group. Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial. Br J Anaesth. 2011 Dec;107(6):899-910. doi: 10.1093/bja/aer274. Epub 2011 Aug 27.

family: Mantz

full_name: J. Mantz

given: J.

family: Samama

full_name: C.M. Samama

family: Tubach

full_name: F. Tubach

given: F.

family: Devereaux

full_name: P.J. Devereaux

family: Collet

full_name: J.-P. Collet

family: Albaladejo

full_name: P. Albaladejo

given: P.

family: Cholley

full_name: B. Cholley

given: B.

family: Nizard

full_name: R. Nizard

given: R.

family: Barré

full_name: J. Barré

family: Piriou

full_name: V. Piriou

given: V.

family: Poirier

full_name: N. Poirier

given: N.

family: Mignon

full_name: A. Mignon

given: A.

family: Schlumberger

full_name: S. Schlumberger

given: S.

family: Longrois

full_name: D. Longrois

given: D.

family: Aubrun

full_name: F. Aubrun

family: Farèse

full_name: M.E. Farèse

family: Ravaud

full_name: P. Ravaud

family: Steg

full_name: P.G. Steg

journal_name: British Journal of Anaesthesia

title: Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial †

lead_sponsor: Assistance Publique - Hôpitaux de Paris


title: Comparison Expectant With Immediate Medical Management for the Evacuation of the no Evolutionary Pregnancies Before 13 GW

summary: Compared the interest of one week expectancy vs immediate medical treatment in the taking care of the evacuation of the no evolutionary pregnancies before 13 GW.

ReferenceCitation: Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID. Methods for managing miscarriage: a network meta-analysis. Cochrane Database Syst Rev. 2021 Jun 1;6:CD012602. doi: 10.1002/14651858.CD012602.pub2.

name: Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research (IMSR), WHO Collaborating Centre for Global Women’s Health Research; University of Birmingham; Birmingham UK

family: Ghosh

full_name: Jay Ghosh

given: Jay

family: Papadopoulou

full_name: Argyro Papadopoulou

given: Argyro

family: Devall

full_name: Adam J Devall

given: Adam J

family: Jeffery

full_name: Hannah C Jeffery

given: Hannah C

name: Institute of Applied Health Research, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK

family: Beeson

full_name: Leanne E Beeson

given: Leanne E

family: Do

full_name: Vivian Do

given: Vivian

name: Test Evaluation Research Group, Institute of Applied Health Research; University of Birmingham; Birmingham UK

family: Price

full_name: Malcolm J Price

given: Malcolm J

family: Tobias

full_name: Aurelio Tobias

given: Aurelio

name: UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research; World Health Organization; Geneva Switzerland

family: Tunçalp

full_name: Özge Tunçalp

given: Özge

family: Lavelanet

full_name: Antonella Lavelanet

given: Antonella

family: Gülmezoglu

full_name: Ahmet Metin Gülmezoglu

given: Ahmet Metin

family: Coomarasamy

full_name: Arri Coomarasamy

given: Arri

family: Gallos

full_name: Ioannis D Gallos

given: Ioannis D

journal_name: Cochrane Database of Systematic Reviews

evidence: oa repository (via OAI-PMH title and last author match)

repository_institution: University of Birmingham - University of Birmingham Research Portal

repository_normalized: Pure (Denmark)

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

ReferenceCitation: Torre A, Huchon C, Bussieres L, Machevin E, Camus E, Fauconnier A. Immediate versus delayed medical treatment for first-trimester miscarriage: a randomized trial. Am J Obstet Gynecol. 2012 Mar;206(3):215.e1-6. doi: 10.1016/j.ajog.2011.12.009. Epub 2011 Dec 16.

family: Torre

full_name: Antoine Torre

given: Antoine

family: Huchon

full_name: Cyrille Huchon

given: Cyrille

family: Bussieres

full_name: Laurence Bussieres

given: Laurence

family: Machevin

full_name: Elise Machevin

given: Elise

family: Camus

full_name: Erick Camus

given: Erick

family: Fauconnier

full_name: Arnaud Fauconnier

journal_name: American Journal of Obstetrics and Gynecology


title: COVID-19: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses: Double-blind, Randomized, Placebo-controlled Clinical Study

acronym: BBCovid

summary: Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission. The modes of person-to-person transmission of SARS-CoV-2 are direct transmission, such as sneezing, coughing, transmission through inhalation of small droplets, and transmission through contact, such as contact with nasal, oral and eye mucous membranes. SARS-CoV-2 can also be transmitted directly or indirectly through saliva. The use of antiviral mouthrinses may be used as adjunctive therapy.

ReferenceCitation: Carrouel F, Conte MP, Fisher J, Gonçalves LS, Dussart C, Llodra JC, Bourgeois D. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. J Clin Med. 2020 Apr 15;9(4). pii: E1126. doi: 10.3390/jcm9041126.

ReferenceCitation: Carrouel F, Gonçalves LS, Conte MP, Campus G, Fisher J, Fraticelli L, Gadea-Deschamps E, Ottolenghi L, Bourgeois D. Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2. J Dent Res. 2021 Feb;100(2):124-132. doi: 10.1177/0022034520967933. Epub 2020 Oct 22. Review.

ReferenceCitation: Carrouel F, Viennot S, Valette M, Cohen JM, Dussart C, Bourgeois D. Salivary and Nasal Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses (BBCovid): A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Nov 2;21(1):906. doi: 10.1186/s13063-020-04846-6.

family: Carrouel

full_name: Florence Carrouel

given: Florence

family: Viennot

full_name: Stéphane Viennot

given: Stéphane

family: Valette

full_name: Martine Valette

given: Martine

family: Cohen

full_name: Jean-Marie Cohen

given: Jean-Marie

family: Dussart

full_name: Claude Dussart

given: Claude

family: Bourgeois

full_name: Denis Bourgeois

given: Denis

currency_apc_doaj: GBP

journal_name: Trials

oa_colors: green gold

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repositories:
HAL
PubMed Central

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

ReferenceCitation: Burton MJ, Clarkson JE, Goulao B, Glenny AM, McBain AJ, Schilder AG, Webster KE, Worthington HV. Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them. Cochrane Database Syst Rev. 2020 Sep 16;9:CD013627. doi: 10.1002/14651858.CD013627.pub2.

family: Burton

full_name: Martin J Burton

given: Martin J

name: Division of Oral Health Sciences; Dundee Dental School, University of Dundee; Dundee UK

family: Clarkson

full_name: Janet E Clarkson

given: Janet E

name: Heath Services Research Unit; University of Aberdeen; Aberdeen UK

family: Goulao

full_name: Beatriz Goulao

given: Beatriz

name: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health; The University of Manchester; Manchester UK

family: Glenny

full_name: Anne-Marie Glenny

given: Anne-Marie

name: Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health; The University of Manchester; Manchester UK

family: McBain

full_name: Andrew J McBain

given: Andrew J

name: evidENT, Ear Institute; University College London; London UK

name: National Institute of Health Research; University College London Hospitals Biomedical Research Centre; London UK

family: Schilder

full_name: Anne GM Schilder

given: Anne GM

name: Cochrane ENT; Nuffield Department of Surgical Sciences, University of Oxford; Oxford UK

family: Webster

full_name: Katie E Webster

given: Katie E

name: Cochrane Oral Health; Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester; Manchester UK

family: Worthington

repository_institution: Aberdeen University - Aberdeen University Research Archive

repository_institution: University of Dundee - Discovery Research Portal

repository_institution: University College London - UCL Discovery

repository_institution: University of Oxford - Oxford University Research Archive (ORA)

location_facility: Intercommunal Hospital Center of Mont de Marsan

location_facility: Clinic of the Protestant Infirmary in Lyon