ReferenceCitation: De Giorgi U, Hussain M, Shore N, Fizazi K, Tombal B, Penson D, Saad F, Efstathiou E, Madziarska K, Steinberg J, Sugg J, Lin X, Shen Q, Sternberg CN. Consistent survival benefit of enzalutamide plus androgen deprivation therapy in men with nonmetastatic castration-resistant prostate cancer: PROSPER subgroup analysis by age and region. Eur J Cancer. 2021 Nov 13;159:237-246. doi: 10.1016/j.ejca.2021.10.015. [Epub ahead of print]

family: De Giorgi

full_name: Ugo De Giorgi

given: Ugo

family: Hussain

full_name: Maha Hussain

given: Maha

family: Shore

full_name: Neal Shore

given: Neal

family: Fizazi

full_name: Karim Fizazi

given: Karim

family: Tombal

full_name: Bertrand Tombal

given: Bertrand

family: Penson

full_name: David Penson

given: David

family: Saad

full_name: Fred Saad

given: Fred

family: Efstathiou

full_name: Eleni Efstathiou

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family: Madziarska

full_name: Katarzyna Madziarska

given: Katarzyna

family: Steinberg

full_name: Joyce Steinberg

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family: Sugg

full_name: Jennifer Sugg

given: Jennifer

family: Lin

full_name: Xun Lin

given: Xun

family: Shen

full_name: Qi Shen

given: Qi

family: Sternberg

full_name: Cora N. Sternberg

given: Cora N.

journal_name: European Journal of Cancer

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

ReferenceCitation: Saad F, Sternberg CN, Efstathiou E, Fizazi K, Modelska K, Lin X, Sugg J, Steinberg J, Noerby B, Shore ND, Hussain M. Prostate-specific Antigen Progression in Enzalutamide-treated Men with Nonmetastatic Castration-resistant Prostate Cancer: Any Rise in Prostate-specific Antigen May Require Closer Monitoring. Eur Urol. 2020 Dec;78(6):847-853. doi: 10.1016/j.eururo.2020.08.025. Epub 2020 Oct 1.

family: Modelska

full_name: Katharina Modelska

given: Katharina

repository_institution: University of Southern Denmark - University of Southern Denmark Research Portal

ReferenceCitation: Sternberg CN, Fizazi K, Saad F, Shore ND, De Giorgi U, Penson DF, Ferreira U, Efstathiou E, Madziarska K, Kolinsky MP, Cubero DIG, Noerby B, Zohren F, Lin X, Modelska K, Sugg J, Steinberg J, Hussain M; PROSPER Investigators. Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer. N Engl J Med. 2020 Jun 4;382(23):2197-2206. doi: 10.1056/NEJMoa2003892. Epub 2020 May 29.

name: From the Englander Institute for Precision Medicine, Weill Cornell Medicine, New York (C.N.S.); the University of Paris Saclay, Villejuif, France (K.F.); the University of Montreal Hospital Center, Montreal (F.S.), and Cross Cancer Institute, University of Alberta, Edmonton (M.P.K.) — both in Canada; the Carolina Urologic Research Center, Myrtle Beach, SC (N.D.S.); Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy (U.D.); Vanderbilt University, Nashville (D.F...

ReferenceCitation: Tombal B, Saad F, Penson D, Hussain M, Sternberg CN, Morlock R, Ramaswamy K, Ivanescu C, Attard G. Patient-reported outcomes following enzalutamide or placebo in men with non-metastatic, castration-resistant prostate cancer (PROSPER): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2019 Apr;20(4):556-569. doi: 10.1016/S1470-2045(18)30898-2. Epub 2019 Feb 12.

repositories_institution: University College London - UCL Discovery

ReferenceCitation: Hussain M, Fizazi K, Saad F, Rathenborg P, Shore N, Ferreira U, Ivashchenko P, Demirhan E, Modelska K, Phung, Krivoshik A, Sternberg CN. Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer. N Engl J Med. 2018 Jun 28;378(26):2465-2474. doi: 10.1056/NEJMoa1800536.

name: From the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago (M.H.), and Astellas Pharma, Northbrook (D.P., A.K.) — both in Illinois; Institut Gustave Roussy, University of Paris Sud, Villejuif, France (K.F.); the University of Montreal Hospital Center, Montreal (F.S.); Herlev Hospital, Herlev, Denmark (P.R.); Carolina Urologic Research Center, Myrtle Beach, SC (N.S.); State University of Campinas (Unicamp), Campinas, Brazil (U.F.); Kiev City...

ipd_sharing_description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

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title: PROSPER: A MULTINATIONAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, EFFICACY AND SAFETY STUDY OF ENZALUTAMIDE IN PATIENTS WITH NONMETASTATIC CASTRATION-RESISTANT PROSTATE CANCER

summary: The purpose of this study is to assess the safety and efficacy of enzalutamide in patients with non metastatic prostate cancer.


title: An Open-label, Multi-center, Three Arm Randomized Study to Investigate the Safety and Efficacy on Progression-free Survival of RO5072759 + Chlorambucil (GClb) Compared to Rituximab + Chlorambucil (RClb) or Chlorambucil (Clb) Alone in Previously Untreated CLL Patients With Comorbidities

summary: This open-label, randomized, 3-arm study will evaluate the efficacy and safety of obinutuzumab (RO5072759) in combination with chlorambucil as compared to rituximab plus chlorambucil or chlorambucil alone in patients with previously untreated chronic lymphocytic leukemia (CLL). Patients will be randomized 2:2:1 to receive a maximum of six 28-day cycles of either RO5072759 (1000mg iv infusion, on days 1, 8 and 15 of cycle 1 and day 1 of cycles 2-6) plus chlorambucil (0.5 mg/kg orally, days 1 and 15 of cycles 1-6), or rituximab (iv infusion day 1, 375 mg/m^2 cycle 1, 500 mg/m^2 cycles 2-6) plus chlorambucil, or chlorambucil alone. Anticipated time on study treatment is >6 months and follow-up for disease-progression and safety will be at least 5 years. In the US, this trial is sponsored/managed by Genentech.

study_start_date_type: Actual

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

lead_sponsor: Hoffmann-La Roche

location_country:
Romania
Australia
Russian Federation
Denmark
Spain
Croatia
France
Thailand
Slovakia
Argentina
Canada
Hong Kong
Netherlands
Switzerland
Bulgaria
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Czechia
Egypt
New Zealand
Estonia

intervention_type: Drug

lead_sponsor_type: industriel

status_simplified: Completed


ReferenceType: derived

ReferenceCitation: Evans SR, Knutsson M, Amarenco P, Albers GW, Bath PM, Denison H, Ladenvall P, Jonasson J, Easton JD, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC. Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clin Trials. 2020 Dec;17(6):617-626. doi: 10.1177/1740774520941441. Epub 2020 Jul 15.

name: Biostatistics Center, George Washington University, Washington, DC, USA

family: Evans

full_name: Scott R Evans

given: Scott R

sequence: first

name: AstraZeneca, Research and Development, Gothenburg, Sweden

family: Knutsson

full_name: Mikael Knutsson

given: Mikael

sequence: additional

name: Department of Neurology and Stroke Centre, Bichat Hospital, Paris University, Paris, France

family: Amarenco

full_name: Pierre Amarenco

given: Pierre

name: Stanford Stroke Center, Stanford University, Stanford, CA, USA

family: Albers

full_name: Gregory W Albers

given: Gregory W

name: Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK

family: Bath

full_name: Philip M Bath

given: Philip M

family: Denison

full_name: Hans Denison

given: Hans

family: Ladenvall

full_name: Per Ladenvall

given: Per

family: Jonasson

full_name: Jenny Jonasson

given: Jenny

name: Department of Neurology, University of California, San Francisco, CA, USA

family: Easton

full_name: J Donald Easton

given: J Donald

name: National Cerebral and Cardiovascular Center, Osaka, Japan

family: Minematsu

full_name: Kazuo Minematsu

given: Kazuo

name: Stroke Unit, Hospital Vall d’Hebron, Barcelona, Spain

family: Molina

full_name: Carlos A Molina

given: Carlos A

name: Department of Neurology, Beijing Tiantan Hospital, Beijing, China

family: Wang

full_name: Yongjun Wang

given: Yongjun

name: Department of Medicine & Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong

family: Wong

full_name: KS Lawrence Wong

given: KS Lawrence

name: Dean’s Office, Dell Medical School, University of Texas at Austin, Austin, TX, USA

family: Johnston

full_name: S Claiborne Johnston

given: S Claiborne

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Clinical Trials

oa_host_type: repository

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

license: cc-by

license_normalized: cc-by

repository_institution: University of Nottingham - Repository@Nottingham

version: acceptedVersion

license_normalized: no license

url: https://nottingham-repository.worktribe.com/4632027/1/ct-19-0268-r3 socrates net clinical benefit paper revised in response to comments tracked for submission 19may2020

url_for_landing_page: https://nottingham-repository.worktribe.com/4632027/1/CT-19-0268-R3 SOCRATES Net Clinical Benefit Paper Revised In Response To Comments TRACKED For Submission 19May2020

repositories_institution: University of Nottingham - Repository@Nottingham

publisher: SAGE Publications

publisher_dissemination: SAGE Publications

publisher_group: SAGE Publications

publisher_normalized: SAGE Publications

ReferenceCitation: Cucchiara B, George DK, Kasner SE, Knutsson M, Denison H, Ladenvall P, Amarenco P, Johnston SC. Disability after minor stroke and TIA: A secondary analysis of the SOCRATES trial. Neurology. 2019 Aug 13;93(7):e708-e716. doi: 10.1212/WNL.0000000000007936. Epub 2019 Jul 11.

family: Cucchiara

full_name: Brett Cucchiara

given: Brett

family: George

full_name: Donna Kurowski George

given: Donna Kurowski

family: Kasner

full_name: Scott E. Kasner

given: Scott E.

publisher: Ovid Technologies (Wolters Kluwer Health)

title: Disability after minor stroke and TIA

ReferenceCitation: Easton JD, Denison H, Evans SR, Knutsson M, Amarenco P, Albers GW, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC; SOCRATES Steering Committee and Investigators. Estimated treatment effect of ticagrelor versus aspirin by investigator-assessed events compared with judgement by an independent event adjudication committee in the SOCRATES trial. Int J Stroke. 2019 Dec;14(9):908-914. doi: 10.1177/1747493019851282. Epub 2019 May 15.

name: Department of Neurology, University of California, San Francisco, USA

name: Biostatistics Center, George Washington University, Washington, USA

name: Stanford Stroke Center, Stanford University, Stanford, USA

name: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan

name: Stroke Unit, Hospital Vall d'Hebron, Barcelona, Spain

name: Dean’s Office, Dell Medical School, University of Texas at Austin, Austin, USA

name: for the SOCRATES Steering Committee and Investigators

ReferenceCitation: Molina CA, Johnston SC, Ladenvall P, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Knutsson M, Minematsu K, Röther J, Wang Y, Wong KSL; SOCRATES Steering Committee and Investigators. Time to Loading Dose and Risk of Recurrent Events in the SOCRATES Trial. Stroke. 2019 Mar;50(3):675-682. doi: 10.1161/STROKEAHA.118.022675. Erratum in: Stroke. 2019 Apr;50(4):e118.

name: From the Stroke Unit, Hospital Vall d’Hebron, Barcelona, Spain (C.A.M.)

name: Dean’s Office, Dell Medical School, University of Texas, Austin (S.C.J.)

name: Global Medicines Development, AstraZeneca, Gothenburg, Sweden (P.L., H.D., P.H., M.K.)

name: Department of Neurology and Stroke Center, Bichat University Hospital and Paris-Diderot, Sorbonne University, France (P.A.)

name: Stanford Stroke Center, Stanford University, Palo Alto, CA (G.W.A.)

name: Department of Biostatistics, Harvard University, Boston, MA (S.R.E.)

name: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (K.M.)

name: Department of Neurology, Asklepios Klinik Altona, Hamburg, Germany (J.R.)

name: Department of Neurology, Tiantan Hospital, Beijing, China (Y.W.)

name: Department of Medicine & Therapeutics, The Chinese University of Hong Kong (K.S.L.W.).

ReferenceCitation: Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18.

name: From the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin (K.S.L.W.)

name: Department of Neurology and Stroke Centre, Bichat Hospital, Paris Diderot University, France (P.A.)

name: Stanford Stroke Center, Stanford University, CA (G.W.A.)

name: Global Medicines Development, AstraZeneca, Gothenburg, Sweden (H.D., P.H., A.H., M.K., P.L.)

name: Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.)

name: Department of Neurology, Beijing Tiantan Hospital, China (Y.W.)

name: Dean’s Office, Dell Medical School, University of Texas at Austin (S.C.J.).

ReferenceCitation: Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. Stroke. 2017 Sep;48(9):2480-2487. doi: 10.1161/STROKEAHA.117.017217. Epub 2017 Jul 18.

name: From the Department of Neurology and Stroke Center, Bichat University Hospital and Paris-Diderot, Sorbonne University, Paris, France (P.A.); Stanford University Medical Center, Stanford Stroke Center, Palo Alto, CA (G.W.A.); AstraZeneca, Gothenburg, Sweden (H.D., P.H., J.J., P.L.); Department of Neurology, University of California San Francisco (J.D.E.); Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA (S.R.E.); Department of Clinical Neurosciences, Hotchkiss Brain...

ReferenceCitation: Easton JD, Aunes M, Albers GW, Amarenco P, Bokelund-Singh S, Denison H, Evans SR, Held P, Jahreskog M, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Circulation. 2017 Sep 5;136(10):907-916. doi: 10.1161/CIRCULATIONAHA.117.028566. Epub 2017 Jun 27.

name: From Department of Neurology, University of California, San Francisco (J.D.E.); AstraZeneca, Gothenburg, Sweden (M.A., S.B.-S., H.D., P.H., M.J., J.J.); Stanford University Medical Center, Stanford Stroke Center, Palo Alto, CA (G.W.A.); Department of Neurology and Stroke Center, Bichat University Hospital and Medical School, Paris, France (P.A.); Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (S.R.E.); National Cerebral and Cardiovascular Center, Suita, Osaka,...

name: For the SOCRATES Steering Committee and Investigators

ReferenceCitation: Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol. 2017 Apr;16(4):301-310. doi: 10.1016/S1474-4422(17)30038-8. Epub 2017 Feb 23.

ReferenceCitation: Wang Y, Minematsu K, Wong KS, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Molina CA, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Stroke. 2017 Jan;48(1):167-173. doi: 10.1161/STROKEAHA.116.014891. Epub 2016 Nov 29.

name: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.W.); China National Clinical Research Center for Neurological Diseases, Beijing (Y.W.); Center of Stroke, Beijing Institute for Brain Disorders, China (Y.W.); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (Y.W.); National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (K.M.); Department of Medicine and Therapeutics, Chinese University of Hong Kong (K.S.L.W....

ReferenceCitation: Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10. Review.

name: Global Medicines Development, AstraZeneca Gothenburg, Pepparedsleden 1, SE-431 83 Mölndal, Sweden

ReferenceCitation: Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Jul 7;375(1):35-43. doi: 10.1056/NEJMoa1603060. Epub 2016 May 10.

location_country:
Peru
Romania
Belgium
Australia
Russian Federation
Taiwan
Ukraine
France
Japan
Poland
Slovakia
Thailand
Argentina
Canada
Korea, Republic of
Chile
Sweden
Hong Kong
Switzerland
Philippines
Vietnam
Bulgaria
Hungary
China
Germany
United States
Italy
Brazil
Mexico
Czechia
Israel
Spain
Turkey

title: A Randomised, Double-Blind, Multinational Study to Prevent Major Vascular Events With Ticagrelor Compared to Aspirin (ASA) in Patients With Acute Ischaemic Stroke or TIA.

summary: The primary objective of the study is to compare the effect of 90-day treatment with ticagrelor (180 mg [two 90 mg tablets] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-aspirin (300 mg [three 100 mg tablets] loading dose on Day 1 followed by 100 mg once daily maintenance dose for the remainder of the study) for the prevention of major vascular events (composite of stroke, myocardial infarction [MI], and death) in patients with acute ischaemic stroke or transient ischaemic attack (TIA).


type: Other Identifier

title: A Prospective, Multi-center Registry for Patients With Short Bowel Syndrome

summary: This is a global prospective, observational, multi-center registry to evaluate the long-term safety profile for participants with short bowel syndrome (SBS) who are treated with teduglutide in a routine clinical setting. The registry will also evaluate the long-term clinical outcomes in participants with SBS. SBS participants treated and not treated with teduglutide will be enrolled.

status: Recruiting

study_completion_date_type: Anticipated

study_type: Observational

time_perspective: Prospective

enrollment_type: Anticipated

ipd_sharing: Yes

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

lead_sponsor: Shire

location_country:
Italy
United States
Sweden
Switzerland
Germany
Finland
France
Norway
Argentina
Spain
Denmark
Canada
United Kingdom

location_facility: Gastroenterology Research of San Antonio, LLC

location_facility: Vanderbilt University Medical Center Diagnostic Lab

location_facility: University of Mississippi Medical Center

location_facility: University of Florida College of Medicine

location_facility: University of Wisconsin Hospital and Clinics

location_facility: Kinderklinik im Dr. von Haunerschen Kinderspital

location_facility: University of Kansas Medical Center Research Institute, Inc.

location_facility: The Gastroenterology Group of South Jersey

location_facility: Klinik fuer Pneumologie-III. Medizinische Klinik

location_facility: CHU de Nancy - Hôpital de Brabois Adultes

location_facility: Gastro-Entérologie Hépato et Nutrition Pédiatrique

location_facility: Perlmutter Cancer Center NYU Langone Health

location_facility: Metabolic Medicine & Weight Control Center

location_facility: St. Olavs Hospital Hf, Universitetssykehuset i Trondheim

location_facility: Service de gastro enterologie pediatrique

location_facility: University of North Carolina at Chapel Hill

location_facility: University of Miami Schiff Center for Liver Disease

location_facility: Service de Gastro-Entérologie Pédiatrique

location_facility: Cleveland Clinic - Gastroenterology and Hepatology

location_facility: Great Ormond Street Hospital for Children

location_facility: Klinik und Poliklinik fuer Kinder- und Jugendmediz

location_facility: CHU de Grenoble - Hôpital Albert Michallon

location_facility: Gastroenterology Associates of Fairfield County

location_facility: Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

location_facility: Groupe Hospitalier Sud - Hôpital Haut-Lévêque

location_facility: U.o.C. Area Centralizzata di medicina Interna e Nu

location_facility: Clinical Associates in Research Therapeutics of America

location_facility: University of Tennessee Health Sciences Center

status_simplified: Ongoing


type: EudraCT Number

title: Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects

summary: This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).

status: Terminated

primary_purpose: Prevention

ReferenceCitation: Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1.

name: Department of Medicine, Division of Cardiovascular Medicine, VA Boston Healthcare System, West Roxbury Campus, MA (A.D.P.).

name: Division of Preventive Medicine (A.D.P., A.W.A., L.M.R., P.M.R.)

family: Pradhan

full_name: Aruna D. Pradhan

given: Aruna D.

name: Department of Medicine, Division of Cardiovascular Medicine (A.W.A., P.M.R.), Brigham and Women’s Hospital, Boston, MA.

family: Aday

full_name: Aaron W. Aday

given: Aaron W.

family: Rose

full_name: Lynda M. Rose

given: Lynda M.

family: Ridker

full_name: Paul M Ridker

given: Paul M

journal_name: Circulation

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via free pdf)

host_type: publisher

version: publishedVersion

evidence: oa repository (via pmcid lookup)

repository_normalized: PubMed Central

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

title: Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy

ReferenceCitation: Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul - Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3.

family: Kastelein

full_name: John J.P. Kastelein

given: John J.P.

family: Santos

full_name: Raul D. Santos

given: Raul D.

family: Wei

full_name: Caimiao Wei

given: Caimiao

family: Revkin

full_name: James Revkin

given: James

family: Yunis

full_name: Carla Yunis

given: Carla

family: Tardif

full_name: Jean-Claude Tardif

given: Jean-Claude

family: Shear

full_name: Charles L. Shear

given: Charles L.

journal_name: Journal of Clinical Lipidology

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

ReferenceCitation: Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.

repository_institution: Red Federada de Repositorios Institucionales de Publicaciones Científicas - LA Referencia

repository_institution: Maastricht University - Research Publications

repository_institution: Nova Science Publishers, Inc. - Nova Science Publishers

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: Universidade Federal do Rio Grande do Sul - Lume

repository_institution: University of Zaragoza Repository - Zaguan

repository_institution: The University of Glasgow - Enlighten: Publications

repository_institution: University of East Anglia - UEA Digital Repository

repositories_institution: Maastricht University - Research Publications

repositories_institution: Nova Science Publishers, Inc. - Nova Science Publishers

repositories_institution: The University of Glasgow - Enlighten: Publications

repositories_institution: Universidade Federal do Rio Grande do Sul - Lume

repositories_institution: University of East Anglia - UEA Digital Repository

repositories_institution: University of Zaragoza Repository - Zaguan

title: Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

location_country:
Finland
Romania
Belgium
Australia
Russian Federation
Denmark
Taiwan
India
France
Poland
Thailand
Slovakia
Argentina
Canada
Korea, Republic of
Colombia
South Africa
Chile
Sweden
Switzerland
Netherlands
Hungary
Ireland
Puerto Rico
Germany
United States
United Kingdom
Italy
Brazil
Mexico
Czechia
Israel
New Zealand
Spain
Turkey

location_facility: Black Hills Cardiovascular-Regional Health Research

location_facility: Wake Forest University Health Sciences Institutional Review Board

location_facility: Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol

location_facility: State Autonomous Healthcare Institution "Republic Clinical Hospital"

location_facility: Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi

location_facility: DRK Kliniken Kopenick, Zentrum Klinische Forschung

location_facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

location_facility: Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology

location_facility: Northeast Clinical Research of San Antonio, LLC (NECRSA, LLC)

location_facility: Southern Adelaide Diabetes and Endocrine Service

location_facility: Faculty of Medicine, Srinagarind Hospital, Khon Kaen University

location_facility: SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF

location_facility: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

location_facility: Investigacion en Salud y Metabolismo S.C

location_facility: Spitalul Clinic Colentina, Departament Cardiologie

location_facility: Synexus Helderberg Clinical Research Centre

location_facility: Narodny Endokrinologicky A Diabetologicky Ustav N.O.

location_facility: Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust

location_facility: Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka

location_facility: Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH

location_facility: Zala Megyei Korhaz, Diabetológiai Szakrendelés

location_facility: State Budgetary Educational Institution Of Higher Professional Education

location_facility: IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda

location_facility: Hospital Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska

location_facility: Vseobecna kardiologicka ambulance s.r.o.

location_facility: Universitatsklinikum des Saarlandes Klinik fur Innere Medizin III

location_facility: Wojewodzki Szpital Specjalistyczny we Wroclawiu, Osrodek Badawczo-Rozwojowy

location_facility: Women's & Family Care, LLC D.B.A GTC Research

location_facility: Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning

location_facility: Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek

location_facility: State Budgetary Healthcare Institution (SBHI) N.N. Burdenko Regional Clinical Hospital of Penza

location_facility: MUDr. Kanderkova s.r.o., Diabetologicka ambulancia

location_facility: Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J

location_facility: Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika

location_facility: Foothills Hospital/University of Calgary

location_facility: Hospital Universitario Virgen De La Victoria

location_facility: Cardiovascular Research Center of South Florida

location_facility: San Diego Family Care dba Linda Vista Health Center

location_facility: Admin & Storage only:Northwest Heart Center

location_facility: State Autonomous Healthcare Institution of Yaroslavl Region

location_facility: University Hospital Brussels - Centrum voor hart- en vaatziekten

location_facility: HealthEast St. Joseph's Hospital inpatient Pharmacy

location_facility: Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU

location_facility: County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department

location_facility: MUDr. Antonin Dufka, kardiologicka ambulance

location_facility: Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #26"

location_facility: Dr. Mistodie Cristina Victoria MD, Office of

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: MedStar Union Memorial Heart Specialists

location_facility: Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic"

location_facility: Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski

location_facility: Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, Poradnie Specjalistyczne,

location_facility: St. Joseph Mercy Health System (Drug shipment Only)

location_facility: Austin Institute for Clinical Research,Inc.

location_facility: Universitaets Herzzentrum Freiburg Bad Krozingen

location_facility: Austin Institute for Clinical Research, Inc.

location_facility: Evanston Premier Healthcare Research, LLC

location_facility: CIPADI Centro Integral de Prevencion y Atencion en Diabetes

location_facility: Synexus Polska Sp. z o.o Oddzial w Poznaniu

location_facility: CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda

location_facility: Hvidovre Universitetshospital, Hjerte-lungemedicinsk afdeling

location_facility: Metabolic and Atherosclerosis Research Center

location_facility: "Tyumen Cardiology Center" Affiliate of the FSBSI "Scientific and Research Institution of Cardiology

location_facility: Centro Especializado En Diabetes Y Metabolismo

location_facility: Prywatny Gabinet Lekarski Marianna Janion

location_facility: Institution Centrul Medical Sf. Stefan SRL, Diabet Nutritie si Boli Metabolice

location_facility: Medizinisches Versorgungszentrum am Bahnhof Spandau

location_facility: FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation based on Clinical

location_facility: Cardiovascular Research Institute of Dallas

location_facility: Instituto del Corazon de Bucaramanga S.A.

location_facility: Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni

location_facility: Pfuetzner Science & Health Institute-Gmbh

location_facility: Municipal Autonomous Institution "City Clinical Hospital #14"

location_facility: Uijeongbu St. Mary's Hospital-The Catholic University of Korea

location_facility: Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.

location_facility: Chippenham and Johnston Willis Hospitals, Inc. dba CJW Medical Center

location_facility: CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA

location_facility: UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava

location_facility: Hospital Mae de Deus - Instituto do Cancer

location_facility: Federal State Budgetary Institution "Federal Almazov Medical Research Centre" of

location_facility: Clinical and Translation Research Center (CTRC) University Medical Center of New Orleans, Diagnostic

location_facility: Arcturus Healthcare, PLC, Troy Internal Medicine Research Division

location_facility: Midwest Cardiovascular Research Foundation

location_facility: SC Centrul Medical Policlinico Di Monza SRL, Cardiologie

location_facility: Synexus Manchester Clinical Research Centre-Manchester Science Park

location_facility: SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit

location_facility: GWT-TUD GmbH, Studienzentrum Professor Hanefeld

location_facility: SBHI Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" of Moscow Healthcare Department

location_facility: Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic"

location_facility: State Budget Institution of Healthcare (SBIH) of Moscow "City Clinical Hospital #81

location_facility: Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia

location_facility: Wits Clinical Research-Chris Hani Baragwanath Hospital

location_facility: South Texas Cardiovascular Consultants, PLLC

location_facility: Synexus Thames Valley Clinical Research Centre

location_facility: Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Burger

location_facility: Grand View - Lehigh Valley Health Services, Buxmont Cardiology Division

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15"

location_facility: Gerencia de Gestion integrada de A Coruna

location_facility: Zentrum Klinische Studien Neuwied (ZKSN)

location_facility: Cardiovascular Research of Northwest Indiana, LLC

location_facility: Premier Health Specialists, Inc. (dba Dayton Heart Center)

location_facility: Investigational Product Shipment Address TO: Investigational Drug Services (IDS),

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital - New

location_facility: Atlanta Center for Clinical Research / Internal Medicine

location_facility: Brian Y.L. Wong Medicine Professional Corporation

location_facility: Allina Health System, dba Abbott Northwestern Hospital

location_facility: Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders

location_facility: Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University

location_facility: State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary"

location_facility: The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde

location_facility: Clinical Trials Unit,Bay of Plenty(BOP) Clinical School

location_facility: "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases,

location_facility: Fakultni poliklinika Vseobecne fakultni nemocnice v Praze

location_facility: Mercy Health Youngstown, LLC d/b/a St. Elizabeth Youngstown Hospital

location_facility: Retreat Cardiology LLC, dba Cardiology Associates of Richmond

location_facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach

location_facility: State Autonomous Healthcare Institution of Tyumen region "Scientific-Practical Medical Center"

location_facility: Baskent University, Adana Yuregir Training & Research Hospital

location_facility: Narodny ustav srdcovych a cievnych chorob, a.s.

location_facility: State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10"

location_facility: Region Sjaelland Sygehus Nord, Koge Sygehus

location_facility: Joondalup Cardiovascular Trials Foundation Inc.

location_facility: Heart Center, Songklanagarind Prince of Songkla University

location_facility: PMG Research,Inc d/b/a PMG Research of Knoxville

location_facility: Fundación Cardiovacular de Colombia - Instituto del Corazón de Floridablanca

location_facility: Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna

location_facility: Regionshospitalet Silkeborg, Hjerte Projektkontor

location_facility: Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice

location_facility: Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto

location_facility: Private Practice 'Cardiovascular Detection Center'

location_facility: Cleveland Clinic - Taussig Cancer Institute

location_facility: Synexus Watermeyer Clinical Research Centre

location_facility: Dr. Pop Calin Florin - Cabinet Cardiologie

location_facility: Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka

location_facility: Synexus North East Clinical Research Centre - Hexham General Hospital

location_facility: BV Medical, s.r.o. Diabetologicka ambulancia,

location_facility: Spitalul Clinic Judetean De Urgenta Cluj-Napoca, Diabet Zabarat

location_facility: Ospedale Civile Regionale San Martino, Belluno

location_facility: Green and Seidner Family Practice Associates

location_facility: Municipal Budgetary Institution of Healthcare Municipal Clinical Hospital #3 n.a. M.A. Podgorbunsky

location_facility: Karlkliniken, Skanes Universitetssjukhus i Malmo

location_facility: Shuali Community Clinic, Clalit Health Services

location_facility: SMO.MD GmbH - Zentrum fÃ¼r klinische Studien

location_facility: Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota

location_facility: Philadelphia Health Associates-Adult Medicine

location_facility: Austin Health - Heidelberg Repatriation Hospital

location_facility: Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL, Medicina Interna

location_facility: Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi

location_facility: Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna

location_facility: Hospital Inovamed Cuernavaca (Emergencies)

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: S.C. Centrul Medical "Sanatatea Ta" S.R.L.

location_facility: State Institution of Healthcare "Regional Clinical Hospital"

location_facility: The Red Porto cabin, The James Cook University Hospital

location_facility: Centro Especializado en Diabetes Obesidad y Prevencion de Enfermedades Cardiovasculares, SC.

location_facility: Centro de Pesquisas Medicas Basica e Clinica LTDA

location_facility: Hospital Universitario La Paz; Unidad Metabolico-Vascular

location_facility: Solutions Through Advanced Research, Inc.

location_facility: CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA

location_facility: Roodepoort Medicross Clinical Research Centre

location_facility: Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C.

location_facility: "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider

location_facility: State Regional Budgetary Healthcare Institution

location_facility: DiGiovanna Institute for Medical Education And Research

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika

location_facility: Metabol KLINIK s.r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy

location_facility: State Budgetary Educational Institution of Highest Professional Education

location_facility: State Budgetary Institution "Ryazan Regional Clinical Hospital"

location_facility: Jehangir Clinical Development Centre Pvt. Ltd.

location_facility: Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23"

location_facility: Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet

location_facility: Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron

location_facility: Investigative Clinical Research of Indiana, LLC

location_facility: MetroWest Medical Center - Pharmacy Department

location_facility: Landa Specjalistyczne Gabinety Lekarskie

location_facility: Clinical Research Institute of Northern Virginia

location_facility: Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6"

location_facility: Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U

location_facility: Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni

location_facility: Women's & Family Care, LLC D.B.A. GTC Research

location_facility: FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across

location_facility: Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA.

location_facility: AOU Policlinico "Mater Domini" UOC di Medicina Interna

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice

location_facility: Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital

location_facility: Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran

location_facility: Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1"

location_facility: Ben Yair Community Clinic - Clalit Health Services

location_facility: Herlev Universitetshospital, Kardiologisk afdeling S

location_facility: Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A.

location_facility: Hospital General Universitario de Valencia

location_facility: Endocrine Lipid Diabetes Research Institute

location_facility: Dr. Kapil M. Bhagirath Medical Services Corporation

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie,

location_facility: IP + Dry ice deliveries Sugar Lakes Family Practice

location_facility: Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV

location_facility: Ocean Blue Medical Research Center, Inc.

location_facility: The Lindner Center for Research and Education at The Christ Hospital

location_facility: Institute of Cardiovascular Diseases Timisoara

location_facility: ProMedica Northwest Ohio Cardiology Consultants

location_facility: A.karahisar Kocatepe Universitesi Hastanesi Ahmet Needet Sezer Uygulama ve

location_facility: Clinical Research Advantage,Inc./Medical and Procedural Specilaists of Illinois

location_facility: Cardiology Consultants of Orange County Medical Group, Inc.

location_facility: Jacksonville Center for Clinical Research

location_facility: Vizel Cardiac Research - Saul Vizel Professional Medicine Corporation

location_facility: Detweiler Family Medicine and Associates, PC

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD"

location_facility: North Shore Hospital- Inpatient Pharmacy

location_facility: Hospital Universitario Virgen de las Nieves (HUVN)

location_facility: Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital,

location_facility: Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.

location_facility: 1st Pavlov State Medical University of St. Petersburg

location_facility: Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo

location_facility: Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.

location_facility: Midwest Heart & Vascular Specialists, LLC

location_facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)

location_facility: Clinica Nuevas Tecnologias En Diabetes Y Endocrinologia

location_facility: Hospital Universitario Marques De Valdecilla

location_facility: Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli

location_facility: Kardiocentrum Nitra s.r.o., kardiologicka ambulancia

location_facility: Abertawe Bro Morgannwg University Local Health Board Joint

location_facility: NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C.

location_facility: Synexus Midlands Clinical Research Centre

location_facility: Hampton Roads Center for Clinical Research

location_facility: Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddzial Szybkiej Diagnostyki

location_facility: BKS Research Kft., Albert Schweitzer Korhaz

location_facility: Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia

location_facility: Dip Medicina Interna e Specialita Mediche, Policlinico Umberto I

location_facility: Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre

location_facility: Cardio D&R spol.s.r.o., kardiologicka ambulancia

location_facility: University Hospital Brussels- Diabeteskliniek

location_facility: Hospital Mae de Deus-Associacao Educadora de Sao Carlos-AESC/IMV - Instituto de Medicina Vascular

location_facility: "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """

location_facility: Univerzitna nemocnica Bmtislava, Nemocnica Stare Mesto

location_facility: KARDIO-SANUS spol.,s.r.o.,Kardiologicka, interna a sonograficka ambulancia

location_facility: Hospital de Alta Complejidad "Pte. Juan Domingo Peron"

location_facility: John V. Bernard, MD dba Wellness and Research Center

location_facility: State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8"

location_facility: Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital)

location_facility: Hopital Cardiovasculaire Et Pneumologique Louis Pradel

location_facility: Albert Schweitzer Ziekenhuis-Albert Schweitzer Hospital

location_facility: Apex Heart Institute (A Unit of TCVS Pvt. Ltd)

location_facility: Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA

location_facility: Northwest Houston Clinical Research, PLLC

location_facility: Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED

location_facility: Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat Nutritie si Boli Metabolice

location_facility: Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

location_facility: Oklahoma Heart Hospital Research Foundation

location_facility: Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg

location_facility: St. Mary's Medical Center dba Essentia Health St. Mary's Medical Center

location_facility: Stroke Prevention & Atherosclerosis Research Centre (SPARC)

location_facility: London Road Diagnostic Clinic and Medical Centre

location_facility: FGM-Clinica Paulista de Doencas Cardiovasculares

location_facility: Clinical Research Advantage, Inc./Simon Williamson Clinic

location_facility: Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi

location_facility: Central Coast Local Health District, Gosford Hospital

location_facility: Hospital Clinico Universitario de Santiago de Compostela

location_facility: Klinik am See Rehabilitationszentrum fur Innere Medizin

location_facility: West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc.

location_facility: National Cheng Kung University (NCKU) Hospital

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie,

location_facility: Glacier View Research Institute, Cardiology

location_facility: Rothwell and Desborough Healthcare Group

location_facility: California Medical Research Associates Inc.

location_facility: Saint Luke's Lipid and Diabetes Research Center

location_facility: Ospedale S. Maria della Misericordia -Dipartimento di Medicina, Medicina Interna,

location_facility: Optimamed Specjalistyczne Gabinety Lekarskie

location_facility: State Budgetary Educational Institution of Higher Professional Education

location_facility: Cardiovascular Research Foundation of Southern California

location_facility: Galilee Medical Center, Cardiology Department

location_facility: State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital"

location_facility: South Florida Clinical Research Institute

location_facility: Clinique des maladies lipidiques de Quebec

location_facility: Department of Neurology & Sagol Neuroscience Center

location_facility: Dipartimento delle Patologie Emergenti, Unita di Medicina Interna e Dislipidemie Genetiche

location_facility: Regional Budgetary Healthcare Institution "Cardiology Dispensary"

location_facility: SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko"

location_facility: CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM

location_facility: Hudson Valley Cardiovascular Practice, PC

location_facility: Wojskowy Instytut Medyczny, Klinika Kardiologii i Chorob Wewnetrznych, Centralny Szpital Kliniczny

location_facility: Hospital Universitario Sant Joan de Reus

location_facility: Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez

location_facility: Hospital Universitario Virgen de la Victoria. CE San Jose Obrero

location_facility: Cranbrook Cardiology Research Associates

location_facility: Gottsegen Gyorgy Orszagos Kardiologiai Intezet

location_facility: Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial

location_facility: Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSA-CA) -

location_facility: Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin"

location_facility: Hospital Regional Universitario de Malaga

location_facility: Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III

location_facility: Bogna Gabrylewicz Andrzej Ochala Unimed s.c.

location_facility: IKF Institut fuer klinische Forschung Frankfurt

location_facility: Bochum Research Centre-Synexus Clinical Research GmbH

location_facility: Intercoastal Medical Group (Drug Shipment Address and Administrative)

location_facility: State Autonomous Healthcare Institution of Yaroslavl region Clinical Emergency Hospital n.a..N.V.So

location_facility: Instituto de Cardiologia do Rio Grande do Sul / Fundacao Universitaria de Cardiologia

location_facility: The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC)

location_facility: Grand Hopital de Charleroi, Site St-Joseph

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre

location_facility: Cardiology Research Associates of New Brunswick

location_facility: Altamira Family Medicine And Research Institute

location_facility: Charlotte Maxeke Johannesburg Academic Hospital

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: The Office of Maxine E. Hamilton, MD, PA

location_facility: Centro de Investigacion Medica Integral S.C.

location_facility: Saint Petersburg State Budgetary Institution of Healthcare

location_facility: Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila

location_facility: Canadian Centre for Research on Diabetes

location_facility: Section of Nephrology and Hypertension, LSU Health Sciences Center-New Orleans

location_facility: HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia

location_facility: Albany Medical College, Division of Community Endocrinology

location_facility: Berlin Research Centre-Synexus Clinical Research GmbH

location_facility: Missouri Cardiovascular Specialists, LLP

location_facility: Municipal Budgetary Institution of Healthcare of Novosibirsk

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego

location_facility: Philippe R. Beaudry Medicine Professional Corporation

location_facility: Asociacion IPS Medicos Internistas de Caldas

location_facility: Cardiovascular Clinical Research Institute

location_facility: Morton Plant Mease Health Care, Inc. Cardiovascular Research

location_facility: FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2

location_facility: Istanbul Universitesi Istanbul Tip Fakultesi

location_facility: Centrum Zdrowia Metabolicznego Pawel Bogdanski

location_facility: Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin

location_facility: Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO

location_facility: Dr. Anil K. Gupta Medicine Professional Corporation

location_facility: Synexus Scotland Clinical Research Centre

location_facility: Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda.

location_facility: Tyumen Cardiology Research Center-branch of the Tomsk NRMC

location_facility: Egyesitett Szent Istvan Korhaz es Szent Laszlo Korhaz

location_facility: Memorial Hospital: University of Colorado Health

location_facility: Hospitalsenheden Midt, Regionshospital Viborg

location_facility: Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin

location_facility: New Orleans Center for Clinical Research

location_facility: Hospital Lomas de San Luis lntemacional (Emergencies)

location_facility: Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: CSK MSW w Warszawie, Klinika Kardiologii Zachowawczej i Nadcisnienia Tetniczego

location_facility: Seoul Metropolitan Government - Seoul National University Boramae Medical Center

location_facility: CRI Centro Regiomontano de Investigacion SC

location_facility: Queen Elizabeth II Hospital, East and North Hertfordshire NHS Trust

location_facility: Metabolicke Centrum MUDr. Katariny Raslovej, S.R.O.

location_facility: "Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of

location_facility: Amh/Feasterville Family Health Care Center

location_facility: Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice

location_facility: Cardiology Partners Clinical Research Institute

location_facility: The Royal Liverpool and Broadgreen -University Hospitals NHS

location_facility: Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS

location_facility: Hospitaux Universitaires de Geneve (HUG)

location_facility: Clinical Research Associates of Central PA

location_facility: Klinik und Poliklinik fuer Innere Medizin B-Kardiologie, Angiologie, Pulmologie, Internistische

location_facility: Vergelegen Mediclinic-Helderberg Research Institute

location_facility: Clinresco Centres (Pty) Ltd-Central Professional Suits

location_facility: Vita Health & Medical Center, Inc./Concept Clinical Trials, LLC

location_facility: Radboud University Nijmegen Medical Centre

location_facility: Mid-Cumberland Infectious Disease Consultants, PLC

location_facility: INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie

location_facility: Medivasa S.R.O., Diabetologicka Ambulancia

location_facility: Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Bolurnu

location_facility: VA North Texas Health Care System - Dallas VAMC

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku

location_facility: Synexus Merseyside Clinical Research Centre

location_facility: CCDHB, Wellington Hospital, Clinical Measurement Unit

location_facility: Izmir Tepecik Egitim ve Arastirma Hastanesi

location_facility: Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii

location_facility: Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly

location_facility: Peterborough and Stamford Hospitals NHS Foundation Trust

location_facility: Heart Institute, Hillel Yaffe Medical Center

location_facility: Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel

location_facility: Pharmacology International Research, Inc.

location_facility: University hospitals Leuven - Neurology department

location_facility: Clinical Research Advantage, Inc. (Administrative Mailing Only)

location_facility: MetroWest Medical Center Research Clinic

location_facility: Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

location_facility: Hospital General Universitario de Alicante; Servicio Cardiologia

location_facility: Stredoslovensky ustav srdcovych a cievnych chorob a.s.

location_facility: Gangnam Severance Hospital, Yonsei University Health System

location_facility: Centro De Investigaciones Clinicas Del Litoral S.R.L.

location_facility: Lillehei Clinical Research Unit, University of Minnesota

location_facility: Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli"

location_facility: Mae de Deus - Centro de Oncologia Radioterapica (COR)

location_facility: Klinikum fuer Herz- & Kreislauferkrankungen

location_facility: Arizona Endocrine and Rheumatology Associates

location_facility: Instituto de Investigaciones Clinicas Bahia Blanca

location_facility: Hospital Provincial Dr. Jose Maria Cullen

location_facility: Instituto de Cardiologia de Corrientes "Juana Fca. Cabral"

location_facility: Centro Cientifico Asistencial Jose Luis Accini S.A.S.

location_facility: Central Manchester University Hospitals NHS Foundation Trust

location_facility: Complejo Hospitalario Universitario de Albacete

location_facility: Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada

location_facility: North Ohio Heart Center (Administrative Only)

location_facility: University of Iowa-College of Public Health-Preventive Intervention Center

location_facility: Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga

location_facility: County Clinical Emergency Hospital Oradea

location_facility: Dr. Richard Bon Inc. & Dr. Adam Yeung Inc.

location_facility: Department of Cardiology, Lyell McEwin Hospital

location_facility: Rabin Medical Center, Beilinson Hospital

location_facility: Global Trial Research Center S.A. de C.V.

location_facility: McGlone Practice - Ballieston Health Centre

location_facility: Instituto Medico Ceniclar - Central De Investigaciones Clinicas Argentina - Sanatorio De La Mujer

location_facility: Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o.

location_facility: Podlaski Osrodek Kardiologii Janusz Korecki

location_facility: Unicare Heart Institute & Research Center

location_facility: INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu

location_facility: Westside Medical Associates of Los Angeles

location_facility: UN Bratislava Nemocnica Sv.Cyrila a Metoda, kardiologicka ambulancia 1

location_facility: Caprock Cardiac Center Research Institute Inc.

location_facility: NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.

location_facility: Hallym University Kangdong Sacred Heart Hospital

location_facility: Southern Health & Social Care Trust, Craigavon Area Hospital

location_facility: Hospital Universitari de Tarragona Joan XXIII

location_facility: State Budgetary Healthcare Institution of Nizhegorodskaya Region

location_facility: Advanced Clinical Research of Miami (ACROM) International

location_facility: Clinical Research Advantage, Inc./Michigan Avenue Internists

location_facility: Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, President's

location_facility: Consultorio Dr. Leocadio Gerardo Munoz Beltran

location_facility: State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency

location_facility: Research Institute of the Carolinas of Piedmont Healthcare, PA

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital"

location_facility: Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC / IMV - Instituto de Medicina Vascular

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto

location_facility: Daegu Catholic University Medical Center

location_facility: Hospital Del Pacifico,Centro De Investigacion Clinica Del Pacifico Cicpa,Torre Medica Del Pacifico

location_facility: Kaplan Medical Center Metabolism and Diabetes Clinic, Kaplan Medical Center

location_facility: Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences

location_facility: DIKa centrum s.r.o., Kardiologicka a interni ambulance

location_facility: MHI "City Clinical Hospital 12"of the Healthcare Committee of

location_facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

location_facility: State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1

location_facility: ILAIM Instituto Latinoamericano de Investigaciones Medicas

location_facility: Limited Liability Company International Medical Centre SOGAZ

location_facility: Hospital Central "Dr. Ignacio Morones Prieto"

location_facility: Clinical Investigation Specialists, Inc.

location_facility: Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital"

location_facility: The Heart & Vascular Institute of Florida

location_facility: Instituto de Investigaciones Clinicas Zarate

location_facility: Specjalistyczna Praktyka Lekarska Piotr Kubalski

location_facility: Novant Health Heart and Vascular Institute

location_facility: The Catholic University Of Korea Seoul St.Marys Hospital

location_facility: Clinical Research Advantage, Inc. / Family Medicine Associates

location_facility: CAP Disset De Setembre (Sant Cosme I Sant Damia)

location_facility: Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First

location_facility: "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik

location_facility: EMED Centrum Uslug Medycznych Ewa Smialek

location_facility: State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2"

location_facility: John Muir Physician Network Clinical Research Center

location_facility: Centro de Diagnostico Cardiologico LTDA.

location_facility: State Budgetary Healthcare Institution ¿Region Clinical Hospital #3¿

location_facility: Hospital Universitario San Juan de Alicante

location_facility: CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A.

location_facility: Centro de Investigaciones Clinicas "Instituto del Corazon"

location_facility: Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis)

location_facility: Centro De Especialidades Medicas Del Estado De Veracruz

location_facility: Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University"

location_facility: SPZOZ Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego

location_facility: Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,

location_facility: Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L.

location_facility: Northeast Iowa Medical Education Foundation

location_facility: Rutgers Biomedical and Health Sciences-Robert Wood Johnson Medical School

location_facility: Istanbul Universitesi Kardiyoloji Enstitusu

location_facility: St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare

location_facility: Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda

location_facility: Synexus Leipzig Clinical Research Centre

location_facility: CAEP - Centro Avançado de Estudos e Pesquisas Ltda.

location_facility: Elite Clinical Trials (Additional Administrative Room / Exam Rooms)

location_facility: Pharmacy - Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat

location_facility: Instituto de Investigaciones Clinicas Mar del Plata

location_facility: Pharmacology and Clinical Research S.A. de C.V.

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky, I. interna klinika

location_facility: LeBauer Cardiovascular Research Foundation

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala

location_facility: Synexus Lancashire Clinical Research Centre

location_facility: County Clinical Emergency Hospital Sibiu

location_facility: Hospital General Universitario Morales Meseguer

location_facility: Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi

location_facility: Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice

location_facility: Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden.

location_facility: Instituto Biomedico De Investigacion A.C.

location_facility: Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin

location_facility: T. Joseph Raoof, Md, Inc/Encino Research Center

location_facility: AOUI di Verona - Ospedale Civile Maggiore Borgo Trento

location_facility: Centrum kardiovaskularni prevence 1. LF UK a TN

location_facility: Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu,

location_facility: Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD"

location_facility: MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva

location_facility: Ufuk University School of Medicine, Dr. Ridvan Ege Training & Research Hospital

location_facility: DIAMEL, s.r.o., Diabetologicka ambulancia

location_facility: Clinica Privada de Especialidades Medicas

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego

location_facility: Centre Hospitalier de Cannes- Service de Cardiologie

location_facility: LMC Diabetes & Endocrinology (Thornhill)

location_facility: Hospital Universitario - Associacao Educadora Sao Carlos - AESC

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna

location_facility: Operadora de Hospitales Angeles S.A. de C.V. (Emergencies)

location_facility: Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran"

location_facility: FSBI "Research institute of complex problems of cardio-vascular diseases" of

location_facility: Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie

location_facility: Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia

location_facility: Hospital Clinico Universitario Miguel Servet; Medicina Interna

location_facility: Synexus Polska Sp. z o.o. Oddzial w Warszawie

location_facility: Clinphenomics Gmbh & Co Kg, Studienzentrum

location_facility: Clinical Research Advantage, Inc. / Cassidy Medical Group - Vista

location_facility: Southern Clinical Trials Shirley Ltd Don Beavan Medical Research Centre

location_facility: A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS

location_facility: Instituto de Diabetes Obesidad y Nutricion, S.C.

location_facility: Women's & Family Care D.B.A. GTC Research

location_facility: Consultorio de Endocrinologia y Nutriologia

location_facility: Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut

location_facility: Seoul National University Bundang Hospital

location_facility: Dr. Stephen Pearce Inc. & Dr. Peter K.H. Tan Inc.

location_facility: Ribo Research, LLC dba Peninsula Research

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni

location_facility: Azienda Ospedaliera Universitaria Santa Maria della Misericordia

location_facility: Instytut Kardiologii, Ii Klinika Choroby WieCowej

location_facility: Research Institute of South Florida, Inc.

location_facility: Centre Hospitalier Universitaire de Sherbrooke - Hotel-Dieu

location_facility: MedStar Chesapeake CardioVascular Associates

location_facility: Instituto Cardiovascular De Buenos Aires

location_facility: Gabinet Lekarski Malgorzata Saryusz-Wolska

location_facility: Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiovasculares, S.C.

location_facility: Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi

location_facility: University of Alabama at Birmingham (Drug Shipment)

location_facility: Scarborough Cardiology Research Associates Inc.

location_facility: Centre Hospitalier Universitaire (CHU) de Liege

location_facility: Unidad de Investigacion Clinica y Atencion Medica Hepa S.C.

location_facility: Clinical Research Advantage, Inc./Family Practice Specialists, Ltd.

location_facility: Miguel Sosa-Padilla, MD-Private Practice

location_facility: Unità Operativa Solventi e Unità Poliambulatorio

location_facility: """OSTEO-MEDIC"" s.c. Artur Racewicz, Jerzy Supronik"

location_facility: Doylestown Health Cardiology, a division of Doylestown Health Physicians

location_facility: Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A.

location_facility: Centro de Investigacion Clinica del Pacifico, S.A. de C.V.

location_facility: NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych

location_facility: CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche

location_facility: Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)

location_facility: Fakultni nemocnice Hradec Kralove, III. Interni gerontometabolicka klinika

location_facility: Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie

location_facility: CARDIO D&R s.r.o., Kardiologicka ambulancia

location_facility: Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas

location_facility: Pro Familia Altera Poradnia Wielospecjalistyczna

location_facility: Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej

location_facility: Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room

location_facility: Sparrow Thoracic & Cardiovascular Institute

location_facility: Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna

location_facility: Dr. Mohan Babapulle Medicine Professional Cooperation

location_facility: Holy Spirit Northside Private Hospital Limited

location_facility: Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital

location_facility: Centre integre de sante et de services sociaux de Lanaudiere (CISSSL)

location_facility: Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli

location_facility: Unidad De Investigacion En Salud De Chihuahua S.C.

location_facility: Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"