title: A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome

acronym: AEGIS-II

summary: This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.

primary_purpose: Prevention

lead_sponsor: CSL Behring

location_country:
Peru
Finland
Malaysia
Greece
Romania
Australia
Belgium
Russian Federation
Denmark
Taiwan
Ukraine
Croatia
France
Japan
Lithuania
Poland
Norway
Slovakia
Argentina
Thailand
Canada
Korea, Republic of
Turkey
Colombia
South Africa
Chile
Sweden
Hong Kong
Netherlands
Switzerland
Bulgaria
Singapore
Hungary
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Serbia
Mexico
Czechia
Israel
Georgia
New Zealand
Spain
Estonia
Latvia

location_facility: 2500042 - CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque

location_facility: 6430092 - Yaroslavl Regional Clinical Hospital

location_facility: 8400482 - Amarillo Heart Clinical Research Institute

location_facility: 8260055 - NHS National Waiting Times Centre Golden Jubilee National Hospital

location_facility: 0760061 - Hospital Universitario Maria Aparecida Pedrossian

location_facility: 8040008 - Kyiv City Clinical Hospital No. 1

location_facility: 8400863 - Swedish Medical Center - Providence Campus

location_facility: 1240113 - Niagara Health System, St. Catherines Site

location_facility: 2080016 - Medicinsk Afdeling - Herning Sygehus

location_facility: 8040021 - Heart Institute of the Ministry of Health of Ukraine

location_facility: 8400496 - Advanced Cardiology Associates

location_facility: 2030041 - Nemocnice Pardubickeho kraje, a.s. - Pardubicka nemocnice

location_facility: 7240045 - Hospital Universitario Ramón y Cajal

location_facility: 6430064 - City Hospital for Emergency Care of Rostov-on-Don

location_facility: 4840077 - Unidad de Investigacion en Salud (UIS)

location_facility: 7920028 - Trakya Universitesi Tip Fakultesi - Kardiyoloji Anabilim Dal

location_facility: 6040025 - Hospital Alberto Sabogal Sologuren

location_facility: 6040056 - Instituto Nacional Cardiovascular - INCOR

location_facility: 3480028 - Magyar Honvédség Egészségügyi Központ

location_facility: 3920133 - Kanagawa Cardiovascular and Respiratory Center

location_facility: 8401165 - Ascension Macomb-Oakland Hospital Warren Campus

location_facility: 3480040 - Jahn Ferenc Dél-pesti Kórház és Rendelőintézet

location_facility: 8400667 - Michigan Cardiovascular Institute

location_facility: 0320054 - Clínica Privada de Especialidades Médicas de Villa María

location_facility: 8400507 - The Saint Vincent Heart Center of Indiana

location_facility: 3920093 - Miyazaki Medical Association Hospital

location_facility: 6420071 - Institutului de Boli Cardiovasculare Timişoara

location_facility: 8400998 - Beth Israel Deaconess Medical Center

location_facility: 3800081 - Azienda Ospedaliera Universitaria "Federico II"

location_facility: 8400836 - Our Lady of Lourdes Medical Center

location_facility: 3760034 - Assaf Harofeh Medical Center - Cardiology Division

location_facility: 3000027 - GENERAL HOSPITAL Korgialenio - Benakio HRC

location_facility: 8400570 - Advanced Cardiology Specialists

location_facility: 2680015 - Chapidze Emergency Cardiology Center

location_facility: 8260058 - Royal Devon & Exeter NHS Foundation Trust

location_facility: 6430049 - Pokrovskaya Municipal Hospital

location_facility: 1000045 - MHAT City Clinic - Sv. Georgi EOOD

location_facility: 0400031 - Universitatsklinik fuer Innere Medizin II, Kardiol

location_facility: 3920128 - Tokyo Bay Urayasu Ichikawa Medical Center

location_facility: 0400034 - Klinikum Klagenfurt am Wörthersee

location_facility: 2760139 - Staedtisches Klinikum Dresden-Friedrichstadt - I. Medizinisc

location_facility: 6420049 - Spitalul Clinic Judetean de Urgenta Tîrgu - Mures

location_facility: 7240032 - Hospital Universitari Joan XXIII de Tarragona

location_facility: 8400747 - Phoenix V.A. Health Care System

location_facility: 6160077 - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Puławach

location_facility: 8400881 - North Texas Research Associates

location_facility: 8400684 - UCHealth Memorial Hospital Central - Colorado Springs

location_facility: 7920022 - Marmara Universitesi Tip Fakultesi

location_facility: 7920025 - Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi - Kardiyo

location_facility: 1910019 - Klinicki Bolnicki Centar Rijeka - Susak

location_facility: 2500080 - CHU de Toulouse - Hopital Rangueil - Cardiologie

location_facility: 3480019 - Debreceni Egyetem Klinikai Központ

location_facility: 6160100 - Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii

location_facility: 6420090 - Spitalul Clinic de Urgenţă "Bagdasar-Arseni"

location_facility: 1580002 - Kaohsiung Veterans General Hospital

location_facility: 1700006 - Hospital Universitario San Ignacio

location_facility: 8260101 - United Lincolnshire Hospitals NHS Trust - Lincoln County Hospital

location_facility: 1240106 - McGill University Health Centre (MUHC)

location_facility: 8401120 - Northeast Georgia Medical Center

location_facility: 1240059 - Centre Hospitalier Pierre-Le Gardeur

location_facility: 6420059 - Institutul de Urgenta pentru Boli Cardiovasculare si Transplant

location_facility: 4100014 - Yonsei University, Wonju Severance Christian Hospital

location_facility: 1240062 - Saint Boniface General Hospital

location_facility: 6430065 - SSMU named after V. I. Razumovsky - Scientific Research Institute

location_facility: 8400322 - Wake Forest University Health Sciences, Dept. of Cardiovascular Medicine

location_facility: 1000054 - Multiprofile Hospital for Active Treatment "National Cardiac Hospital"

location_facility: 3000024 - University Hospital of Alexandroupolis

location_facility: 0760036 - Hospital Geral Universitário de Cuiabá - HGU

location_facility: 8400718 - V.A. Pittsburgh Healthcare System

location_facility: 3000025 - University General Hospital of Patras

location_facility: 8260043 - University Hospitals of Leicester NHS Trust - Glenfield

location_facility: 1240058 - University of Alberta Hospital

location_facility: 6160086 - Dept. of Interventional cardiology and Angiology, Institute

location_facility: 1000033 - University Multiprofile Hospital for Active Treatment

location_facility: 3760018 - Leviev Heart Center, Chaim Sheba Medical Center

location_facility: 2760190 - Asklepios Kliniken Hamburg GmbH

location_facility: 4840014 - Investigacion Biomedica para el Desarrollo de Farmacos S.A d

location_facility: 8400563 - Cardiovascular Institute of the South

location_facility: 8400779 - MedStar Clinical Research Center

location_facility: 6430060 - Regional State Budgetary Institution of Public Health

location_facility: 1240090 - New Brunswick Heart Centre Research Initiative

location_facility: 8401054 - Central Cardiology Medical Center

location_facility: 1000056 - Acibadem City Clinic Tokuda Hospital, EAD

location_facility: 6200026 - Centro Hospitalar do Baixo Vouga

location_facility: 0760039 - Hospital Evangelico de Vila Velha (HEVV)

location_facility: 6430048 - City Clinical Hospital No. 6 named after Karpovicha

location_facility: 0320041 - Clinica y Maternidad Suizo Argentina (CyMSA)

location_facility: 6420046 - Spitalului Universitar de Urgenţă Militar Central "Dr. Carol Davila"

location_facility: 6160078 - Nowy Szpital Uniwersytecki w Krakowie-Prokocimiu

location_facility: 4840018 - Centro de Alta Especialidad Dr. Rafael Lucio

location_facility: 6420047 - Spitalul de Urgenta "Sf. Ioan Cel Nou" Suceava

location_facility: 8400491 - Moses H. Cone Memorial Hospital

location_facility: 0320037 - Centro Privado de Cardiologia (CPC)

location_facility: 2030020 - Fakultní nemocnice Královské Vinohrady

location_facility: 3800107 - Università degli Studi "Magna Graecia" di Catanzaro

location_facility: 0760085 - Hospital Universitário São José (HUSJ)

location_facility: 4100021 - Chungbuk National University Hospital

location_facility: 8400862 - Cardiovascular Associates Research

location_facility: 2680002 - Helsicore - Israeli Georgian Medical Research Clinic

location_facility: 1000072 - Multiprofile Hospital for Active Treatment - Dobrich AD

location_facility: 6420083 - Institutului de Boli Cardiovasculare Timişoara

location_facility: 4100025 - Korea University Anam Hospital

location_facility: 2760170 - Charite - UB - CVK - Medizinische Klinik

location_facility: 6420080 - Spitalul Clinic de Recuperare Cluj-Napoca

location_facility: 4840022 - Centro de Atencion e Investigacion Cardiovascular del Potosi

location_facility: 6040031 - Clínica Internacional - Sede San Borja

location_facility: 8401027 - UNC Hospitals Heart and Vascular Center at Meadowmont

location_facility: 8400638 - Mid Michigan Regional Medical Center

location_facility: 3920123 - Tokyo Women's Medical University Hospital

location_facility: 3920119 - Ehime Prefectural Central Hospital

location_facility: 3480045 - Somogy Megyei Kaposi Mór Oktató Kórház

location_facility: 6430116 - City hospital # 2 "Sosnovaya roscha"

location_facility: 8400735 - Parkway Cardiology Associates, PC

location_facility: 5280063 - Zuyderland Medisch Centrum, Heerlen

location_facility: 2680018 - TSMU - Alexandre Aladashvili University Clinic

location_facility: 4840004 - Hospital Cardiológica Aguascal

location_facility: 8400717 - V.A. Greater Los Angeles Healthcare System

location_facility: 1240066 - Centre Integre Universitaire de la Mauricie-et-du-Centre-du-Quebec

location_facility: 4840007 - Unidad de Prevención y Atención Cardiometabólica (UPAC)

location_facility: 1000035 - "MHAT "Sveta Anna"" - Sofia AD

location_facility: 0400028 - Medizinische Universitaet Innsbruck - Universitaetsklinik für Innere Medizin

location_facility: 3480033 - Semmelweis University, Faculty of Medicine

location_facility: 7920029 - Cumhuriyet Universitesi Tip Fakultesi - Kardiyoloji Anabilim

location_facility: 4580016 - University Malaya Medical Centre

location_facility: 4840033 - Virgen Cardiovascular Research S.C.

location_facility: 4100020 - Kyung Hee University Hospital at Gangdong

location_facility: 6160063 - Klinika Kardiologii i Kardiochirurgii 10 WSK

location_facility: 2460011 - Turku University Hospital (TYKS)

location_facility: 6420051 - Institutul Inimii "Niculae Stancioiu"

location_facility: 6200021 - Centro Hospitalar do Alto Ave, EPE

location_facility: 3000013 - University General Hospital of Thessaloniki AHEPA

location_facility: 7920023 - Ege Üniversitesi Tıp Fakültesi

location_facility: 2500120 - Centre Hospitalier Annecy Genevois

location_facility: 4580002 - Hospital Umum Sarawak (HUS) - The Cardiac Centre

location_facility: 8400890 - Revival Research Institute, LLC

location_facility: 3920095 - Showa University Fujigaoka Hospital

location_facility: 8400854 - The Chattanooga Heart Institute

location_facility: 3920114 - Toho University Ohashi Medical Center

location_facility: 8040037 - The Ivano-Frankivsk National Medical Univeristy

location_facility: 8260071 - Ashford and St Peter's Hospitals NHS Foundation Trust

location_facility: 6420088 - Institutul Inimii "Niculae Stancioiu"

location_facility: 1000057 - Specialized Hospital for Active Treatment in Cardiology EAD

location_facility: 8401010 - Integrative Research Associates Inc.

location_facility: 8400996 - Southern Arizona V.A. Healthcare System

location_facility: 0560020 - AZ Sint-Jan Brugge-Oostende AV

location_facility: 8400648 - Saint Luke's Cardiovascular Consultants

location_facility: 3920094 - Juntendo University Shizuoka Hospital

location_facility: 5280048 - Amphia Zienkenhuis - Locatie Molengracht Breda

location_facility: 2080020 - Hjertesygdomme | Regionshospitalerne i Viborg og Skive

location_facility: 3920115 - Matsusaka Chuo General Hospital

location_facility: 0760037 - Hospital de Messejana Dr. Carlos Alberto Gomes Studart

location_facility: 2760146 - Innere Medizin I, Marienhaus Klinikum Eifel Bitburg

location_facility: 8400661 - Norton Cardiovascular Associates

location_facility: 3760025 - Rabin Medical Center - Hasharon Hospital

location_facility: 6420043 - Spitalul Universitar de Urgenta Bucuresti

location_facility: 6420079 - Spitalul Clinic Judetean de Urgenta Sibiu

location_facility: 8040009 - Kiev City Clinical Hospital No. 5

location_facility: 3800082 - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

location_facility: 8400751 - Providence Everett Medical Center

location_facility: 6420048 - Spitalul Judetean de Urgenta Pitesti-Arges

location_facility: 6430063 - Lyubertsy Regional Hospital No. 2

location_facility: 0760069 - Hospital Universitario Evangelico de Curitiba

location_facility: 2760140 - Cardiologicum Hamburg - Studienzentrum

location_facility: 2030057 - Fakultní Nemocnice Hradec Králové

location_facility: 4840045 - OCA Hospital - Monterrey International Research Center

location_facility: 1580001 - Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: 2460006 - Helsinki University Central Hospital (HUCH)

location_facility: 6420045 - Spitalul Clinic Judeţean de Urgenţă Oradea

location_facility: 0320021 - Sanatorio Medico de Diagnostico y Tratamiento S.A.

location_facility: 8400626 - Montefiore Medical Center - Albert Einstein College of Medicine

location_facility: 1000047 - University Hospital for Active Treatment & Emergency Medicine

location_facility: 7100010 - Clinical Projects Research SA (Pty) Ltd.

location_facility: 8400746 - Penn Presbyterian Medical Center

location_facility: 2030052 - Všeobecná fakultní nemocnice v Praze

location_facility: 0760040 - Santa Casa de Misericordia de Pelotas

location_facility: 3000029 - University of Thessaly- General University Hospital of Laris

location_facility: 8260086 - Manchester University NHS Foundation Trust - Manchester Royal Infirmary

location_facility: 6160082 - II Oddział Kardiologiczny PAKS

location_facility: 0760077 - Instituto de Pesquisa Clinica de Campinas

location_facility: 6430115 - Pavlov First Saint Petersburg State Medical University

location_facility: 0320071 - Hospital Provincial del Centenario

location_facility: 7240030 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz

location_facility: 0560036 - Universitair Ziekenhuis Leuven

location_facility: 3760035 - The Baruch Padeh Medical Center

location_facility: 8040032 - Ivano-Frankivskyy oblasnyy klinichnyy kardiologichnyy dyspan

location_facility: 3800106 - Università degli Studi di Roma "La Sapienza"

location_facility: 1240071 - Institut universitaire de cardiologie et de pneumologie de Quebec

location_facility: 8400503 - The Heart and Vascular Center / Holy Family Memorial

location_facility: 2030071 - Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha

location_facility: 7920017 - Eskişehir Osmangazi Üniversitesi Tıp Fakültesi

location_facility: 5280038 - Admiraal de Ruijter Ziekenhuis - Locatie Goes

location_facility: 6160065 - III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokard

location_facility: 0320032 - Hospital Dr. Jose Maria Cullen

location_facility: 8260134 - The Newcastle upon Tyne Hospitals NHS Foundation Trust - Fre

location_facility: 8400713 - University of South Alabama College of Medicine

location_facility: 2760168 - Klinikum Frankfurt Höchst GmbH

location_facility: 4100022 - Hallym University Sacred Heart Hospital

location_facility: 7920012 - Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi

location_facility: 7030006 - Univerzitna Nemocnica Bratislava - Nemocnica Staré Mesto

location_facility: 0560026 - Universitair Ziekenhuis Brussel

location_facility: 8400889 - NC Heart and Vascular Research

location_facility: 3440004 - Queen Elizabeth Hospital (QEH)

location_facility: 2330005 - North Estonia Medical Centre Foundation

location_facility: 3480026 - Zala Megyei Szent Rafael Kórház

location_facility: 6160062 - Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Op

location_facility: 8400596 - Long Beach Memorial Medical Center

location_facility: 1240063 - Heritage Medical Research Clinic

location_facility: 1240099 - Centre Hospital Saint Georges de Beauce

location_facility: 6160096 - 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie

location_facility: 6200022 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospital

location_facility: 6200025 - Unidade Local de Saude de Matosinhos - Hospital Pedro Hispan

location_facility: 6160080 - Regional Public Specialty Hospital "Latawiec"

location_facility: 2080019 - Sjaellands Universitetshospital - Kardiologisk Afdeling

location_facility: 2760167 - Ev. und Johanniter Klinikum Niederrhein, Kardiologie

location_facility: 4840020 - Centro de Estudios de Alta Especialidad de Sinaloa, S.C.

location_facility: 8401175 - Overton Brooks V.A. Medical Center

location_facility: 3800085 - Azienda Socio-Sanitaria Territoriale della Valle Olona

location_facility: 8401178 - Jersey Shore University Medical Center Meridian Health

location_facility: 7240050 - Hospital de la Santa Creu i Sant Pau

location_facility: 8400504 - Integris Baptist Medical Center

location_facility: 1580008 - Mackay Memorial Hospital - Tamsui Branch

location_facility: 7640010 - King Chulalongkorn Memorial Hospital

location_facility: 1240092 - CHUM - Centre Hospitalier de l'Universite de Montreal

location_facility: 0760009 - Santa Casa de Misericordia de Marilia

location_facility: 8400688 - George Washington University Medical Center

location_facility: 8400693 - University of California Los Angeles

location_facility: 8400700 - Mercy Saint Vincent Medical Center

location_facility: 1700007 - Fundacion Cardiomet Eje Cafetero CEQUIN

location_facility: 6430043 - Tula Regional Clinical Hospital

location_facility: 7520011 - Karolinska Universitetssjukhuset - Huddinge

location_facility: 0320027 - Estudios Clínicos de los Arroyos

location_facility: 1240083 - CHU de Quebec-Universite-Laval, HDQ

location_facility: 8401233 - Cincinnati V.A. Medical Center

location_facility: 4840003 - Centro de Estudios Clínicos de Querétaro, SC

location_facility: 4840021 - Universidad Autonoma de Nuevo Leon - Hospital Universitario

location_facility: 7920016 - Ankara Sehir Hastanesi Bilkent

location_facility: 0560046 - AZ Groeninge - Campus Kennedylaan

location_facility: 4280008 - Pauls Stradins Clinical University Hospital

location_facility: 2760111 - Klinikum der Stadt Ludwigshafen gGmbH

location_facility: 2080022 - Amager Sygehus - Kardiologisk Klinik

location_facility: 6430070 - Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine

location_facility: 3000010 - University Hospital of Ioannina

location_facility: 4840025 - Hospital Central "Dr. Ignacio Morones Prieto"

location_facility: 8040023 - Zhitomir Regional Clinical Hospital

location_facility: 8040010 - Dnipropetrovsk Medical Academy, Dnipropetrovsk Joint Emergen

location_facility: 2680012 - Chapidze Emergency Cardiology Center

location_facility: 7640020 - Buddhachinaraj Hospital Phitsanuloke

location_facility: 8401103 - Orange Coast Memorial Hospital

location_facility: 2500162 - CHRU de Tours - Hopital Trousseau

location_facility: 5280060 - Ziekenhuis Rivierenland - Cardiologie

location_facility: 7030001 - Nemocnica arm. Generala L. Svobodu Svidnik, a.s.

location_facility: 0760075 - Instituto D'Or de Pesquisa e Ensino

location_facility: 0760055 - Instituto Cardio Pulmonar da Bahia - Hospital

location_facility: 0760057 - Centro de Cardiologia Clinica e Pesquisa Dra. Juliana Souza

location_facility: 3760037 - Tel Aviv University Sackler School of Medicine - Meir Medica

location_facility: 4400005 - Vilnius University Hospital Santaros Klinikos

location_facility: 8400719 - V.A. San Diego Health Care System

location_facility: 0760053 - Fundação Bahiana de Cardiologia

location_facility: 7240034 - Hospital Clinico Universitario de Valencia

location_facility: 4840006 - Centro para el Desarrollo de la Medicina y de Asistencia Méd

location_facility: 8400379 - John Muir Health and Cardiovascular Institute

location_facility: 1000024 - Multiprofile District Hospital

location_facility: 7920031 - Konya Necmettin Erbakan University Meram Medical Faculty - D

location_facility: 8400543 - Cardiology Partners Research Institute

location_facility: 2680013 - Tbilisi Heart and Vascular Clinic LTD

location_facility: 8401192 - South Orange County Surgical Medical Group

location_facility: 3800123 - AORN - Ospedali dei Colli Ospedale V. Monaldi

location_facility: 7240064 - Hospital General Universitario de Alicante

location_facility: 8400517 - Shands Jacksonville Medical Center

location_facility: 4840016 - Instituto Nacional de Cardiologia Ignacio Chavez

location_facility: 8040050 - Regional Clinical Hospital - Emergency Medical Care

location_facility: 6200017 - Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Hospital

location_facility: 7030002 - Svet zdravia, a.s. - Všeobecná nemocnica Rimavská Sobota

location_facility: 3000008 - University of Ioannina School of Medicine - Michaelidion Cardiac Center

location_facility: 3800170 - Fondazione Poliambulanza Istituto Ospedaliero

location_facility: 3480023 - Petz Aladar County Teaching Hospital

location_facility: 2030073 - Karlovarska Krajska Nemocnice a.s.

location_facility: 8400961 - Indiana Heart Physicians, Inc.

location_facility: 8260088 - Kettering General Hospital NHS Foundation Trust

location_facility: 3920118 - Sapporo Medical University Hospital

location_facility: 0760041 - Hospital e Maternidade Dr. Christovao da Gama

location_facility: 8260065 - Milton Keynes Hospital NHS Foundation Trust

location_facility: 3480035 - Tolna Megyei Balassa Janos Korhaz

location_facility: 7240063 - Hospital Universitario Vall d'Hebron

location_facility: 8400812 - Maine Medical Center Bramhall Campus

location_facility: 2030061 - Oblastní nemocnice Náchod, a.s

location_facility: 7920015 - T.C. Saglik Bakanligi - Kartal Kosuyolu Yuksek Ihtisas Egitim

location_facility: 8040035 - Lviv Regional State Clinical-and-Diagnostic Cardiology Cente

location_facility: 8401141 - Western Michigan University Homer Striker MD School of Medicine

location_facility: 7240054 - Hospital Universitari Son Espases

location_facility: 8400847 - University of Rochester Medical Center-Strong Memorial Hospital

location_facility: 3920106 - Hyogo Prefectural Amagasaki General Medical Center

location_facility: 7240043 - Hospital Universitario Fundación Alcorcón

location_facility: 2500112 - Centre Hospitalier Régional Universitaire de Lille (CHRU)

location_facility: 2760163 - Städtische Kliniken Neuss - Medizinische Klinik I

location_facility: 8400574 - Aurora Denver Cardiology Associates

location_facility: 0320029 - Instituto Cardiovascular de Buenos Aires

location_facility: 1910024 - Klinički Bolnički Centar Split

location_facility: 8401127 - Tulane University Health Science Center

location_facility: 8040016 - Lviv National Medical University named by Danylo Halitskyy

location_facility: 1700017 - Fundación Cardiovascular de Colombia

location_facility: 8400544 - Cardiology Research Associates

location_facility: 8400733 - Novant Health Heart and Vascular Institute

location_facility: 3480022 - University of Szeged - Second Department of Medicine & Cardiology Centre

location_facility: 1910003 - Klinicki Bolnicki Centar Zagreb

location_facility: 8040048 - Communal Institution of Healthcare "Kharkiv Municipal Clinic

location_facility: 4100017 - Chungnam National University Hospital

location_facility: 8400622 - Mercy Medical Research Institute

location_facility: 8400364 - Minneapolis Heart Institute Foundation

location_facility: 2030040 - Oblastní Nemocnice Kladno, a.s.

location_facility: 3920099 - Yokohama City University Medical Center

location_facility: 2500078 - Centre Hospitalier Louis Pasteur

location_facility: 1000071 - University Multiprofile Hospital for Active Treatment "Dr. G"

location_facility: 7240046 - Parc Taulí Sabadell Hospital Universitari

location_facility: 5280031 - Meander Medisch Centrum - Locatie Amersfoort

location_facility: 8040036 - Regional Medical Center for Cardiovascular Diseases

location_facility: 8400921 - Mission Research Institute, LLC

location_facility: 0560022 - Centre Hospitalier Universitaire de Tivoli

location_facility: 8400320 - Black Hills Cardiovascular Research

location_facility: 0760047 - Instituto de Cardiologia de Santa Catarina (ICSC)

location_facility: 2500107 - Centre Hospitalier Sud Francilien

location_facility: 2760164 - Elisabeth-Krankenhaus Essen GmbH Klinik für Kardiologie und Angiologie

location_facility: 3760029 - Hadassah Medical Center-Mount Scopus

location_facility: 8040013 - Khmelnytskyi Regional Hospital

location_facility: 0320017 - Entidades Vinculadas al Sanatorio Parque

location_facility: 6880009 - Department of Cardiology, Clinical Center of Serbia and Belgrade

location_facility: 7020006 - National Heart Center Singapore

location_facility: 1520004 - Hospital Dr. Hernan Henriquez Aravena

location_facility: 0760083 - Irmandade da Santa Casa de Misericordia de Sao Paulo

location_facility: 1240093 - Halton Healthcare - Oakville Trafalgar Memorial Hospital

location_facility: 8400334 - Cardiology Associates of North Mississippi

location_facility: 0560023 - Centre Hospitalier Universitaire Brugmann

location_facility: 6420050 - Spitalul Universitar de Urgent

location_facility: 6430075 - First City Clinical Hospital named after E. E. Volosevich

location_facility: 0320040 - Instituto de Cardiología de Corrientes

location_facility: 8400677 - Saint Joseph's Hospital Cardiac Catheterization Associates

location_facility: 7920032 - Kocaeli Universitesi Tip Fakultesi - Kardiyoloji Anabilim Dalı Başkanı

location_facility: 2680004 - Clinical Cardology Institute Ltd.

location_facility: 6430072 - Samara Regional Cardiology Dispensary

location_facility: 1000029 - Multiprofile Hospital for Active Treatment AD Haskovo

location_facility: 1580004 - Shin Kong Wu Ho-Su Memorial Hospital

location_facility: 8401011 - Cardiology Partners Research Institute

location_facility: 8400369 - HealthEast Saint Joseph's Hospital

location_facility: 6420060 - Spitalul Clinic Judetean de Urgenta Cluj-Napoca

location_facility: 6430067 - Saratov State Medical University named after V.I. Razumovsky

location_facility: 6430050 - Kursk City Emergency Care Hospital

location_facility: 7240068 - Hospital Universitario Marqués de Valdecilla

location_facility: 6880024 - Opsta Bolnica "Dorde Joanovic" Zrenjanin

location_facility: 8400576 - IU Health Ball Memorial Hospital Physicians, Inc

location_facility: 3800110 - Fondazione IRCCS Policlinico San Matteo

location_facility: 6880023 - Kliničko Bolnički Centar Zvezdara

location_facility: 0760027 - CEMEC - Centro Multidisciplinar de Estudos Clínicos

location_facility: 6200012 - Centro Hospitalar e Universitário do Algarve, EPE - Hospital

location_facility: 4580005 - Universiti Teknologi MARA (UiTM)

location_facility: 8260102 - Queen Elizabeth Hospital Birmingham

location_facility: 8400861 - Ascension Providence Rochester Hospital

location_facility: 2500105 - CHU de Nimes - Hopital Universitaire Caremeau

location_facility: 0320019 - Hospital Británico de Buenos Aires

location_facility: 6160051 - Krakowski Szpital Specjalistyczny im. Jana Pawła II

location_facility: 1700012 - Fundación Oftalmológica de Santander - Clinica FOSCAL

location_facility: 1000043 - Multiprofile Hospital for Active Treatment Blagoevgrad AD

location_facility: 3760026 - The Baruch Padeh Medical Center

location_facility: 6880012 - Institute of Cardiovascular Diseases of Vojvodina

location_facility: 1240061 - SMH Cardiology Clinical Trials Inc.

location_facility: 0760016 - Faculdade de Medicina de Sao Jose do Rio Preto-SP - Hospital

location_facility: 5280036 - Canisius-Wilhelmina Ziekenhuis

location_facility: 8400613 - Jim Moran Heart and Vascular Center

location_facility: 6430058 - State Budget Healthcare Institution of Novosibirsk Region "C

location_facility: 8401144 - Saint Michael's Medical Center

location_facility: 3920111 - Ishikawa Prefectural Central Hospital

location_facility: 7920024 - Afyon Kocatepe University Medical Faculty Dept. Of Cardiology

location_facility: 1000044 - Second Multiprofile Hospital for Active Treatment - Sofia EA

location_facility: 8401189 - Cardiovascular Associates of the Delaware Valley

location_facility: 1700024 - Fundación Hospitalaria San Vicente de Paul

location_facility: 8400484 - Clearwater Cardiovascular and Interventional Consultants

location_facility: 0760081 - Hospital Universitário Cassiano Antonio Moraes (HUCAM)

location_facility: 2680025 - Tsinamdzgvrshvili Cardiology Center (German-Georgian Clinic)

location_facility: 6430045 - Penza Regional Clinical Hospital n.a. N.N.Burdenko

location_facility: 0760035 - Loema - Instituto de Pesquisa Clinica

location_facility: 8400975 - Central Arkansas Veterans Healthcare System

location_facility: 6430068 - Regional Budgetary Healthcare Institution "Cardiology Dispensary"

location_facility: 4400006 - Public Institution Republican Panevezys Hospital

location_facility: 8040047 - Oleksandrivska Clinical Hospital

location_facility: 8400502 - Stroobants Cardiovascular Center

location_facility: 3000007 - General Hospital of Nikea "Agios Panteleimon"

location_facility: 8400916 - Southeastern Cardiology & Cardiovascular Clinic

location_facility: 2760157 - SRH Klinikum Karlsbad-Langensteinbach GmbH

location_facility: 3480025 - Dombovari Szent Lukacs Egeszsegugyi Kft

location_facility: 4100013 - Kyung Hee University Medical Center

location_facility: 1520014 - Hospital Clinico Regional Dr. Guillermo Grant Benavente

location_facility: 7920018 - Cukurova University School Of Medicine Balcali Hospital

location_facility: 8400893 - Interventional Cardiology Medical Group

location_facility: 0760011 - Hospital Cardiologico Costantini

location_facility: 4580008 - Universiti Kebangsaan Malaysia Medical Centre

location_facility: 1000038 - Acibadem City Clinic University Hospital, EOOD

location_facility: 3480018 - Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintéz

location_facility: 0320013 - Hospital Municipal de Coronel Suárez

location_facility: 4100016 - Veterans Health Service Medical Center

location_facility: 3920116 - Nihon University Itabashi Hospital

location_facility: 8260057 - Mid Essex Hospital Services NHS Trust - Broomfield Hospital

location_facility: 0560019 - Centre Hospitalier Régional de Huy

location_facility: 2500092 - Centre Hospitalier Régional Metz-Thionville

location_facility: 8400572 - AtlantiCare Regional Medical Center

location_facility: 0760021 - Fundacao Hospitalar Sao Francisco de Assis

location_facility: 8260066 - Torbay and South Devon NHS Foundation Trust - Torbay Hospital

location_facility: 6430081 - Saint Petersburg State Medical Academy

location_facility: 3800087 - Azienda Ospedaliera Universitaria "Federico II"

location_facility: 2030059 - Uherskohradišťská nemocnice a.s.

location_facility: 3920104 - Shizuoka City Shizuoka Hospital

location_facility: 0760038 - Instituto de Cardiologia do Distrito Federal (ICDF)

location_facility: 2760186 - Katholisches Klinikum Mainz - Klinik fuer Innere Medizin I

location_facility: 3000023 - National and Kapodistrian University of Athens (NKUA) - Scho

location_facility: 8400745 - Hoag Memorial Hospital Presbyterian

location_facility: 3800079 - Azienda Ospedaliera di Caserta "Sant'Anna e San Sebastiano"

location_facility: 7030014 - Univerzitna Nemocnica Bratislava - Nemocnica sv. Cyrila a Me

location_facility: 8400891 - John Muir Medical Center Walnu

location_facility: 2680022 - Bokhua Memorial Cardiovascular Center

location_facility: 6880013 - General Hospital Sremska Mitrovica

location_facility: 7240035 - Complexo Hospitalario Universitario A Coruña

location_facility: 7240026 - Hospital General Universitario de Alicante

location_facility: 1580009 - National Taiwan University Hospital

location_facility: 8040012 - Kharkiv City Clinical Hospital #8

location_facility: 8260099 - The Royal Wolverhampton NHS Trust - New Cross Hospital

location_facility: 6200014 - Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Santa

location_facility: 7920030 - T. C. Saglık Bakanlıgı - Bagcılar Egitim ve Arastırma Hastan

location_facility: 2500117 - Centre Chirurgical Marie Lannelongue

location_facility: 6430047 - Novosibirsk Regional Clinical Hospital

location_facility: 6430042 - Research Institute of Cardiology

location_facility: 6430079 - Scientific-Research Institute of Complex Problems of Cardio

location_facility: 8400997 - CardioVascular Institute of North Colorado Cardiology Clinic

location_facility: 5280042 - Elisabeth TweeSteden Ziekenhuis Vestiging Tilburg

location_facility: 8400551 - Cardiovascular Research of Knoxville

location_facility: 8400888 - Saint Jude Heritage Healthcare

location_facility: 3800075 - ASST degli Spedali Civili di Brescia

location_facility: 6430091 - City clinical hospital #15 n.a. O.M. Filatov

location_facility: 2760106 - Universitätsklinikum Hamburg-Eppendorf (UKE)

location_facility: 6430107 - Clinical Hospital of the Russian Academy of Science

location_facility: 8401000 - Advocate Lutheran General Hospital

location_facility: 6420044 - Spitalul Clinic Judetean de Ur

location_facility: 3000022 - University of Athens - Hippokration General Hospital

location_facility: 1240078 - Kawartha Cardiology Clinical Trials

location_facility: 4100024 - Seoul National University Bundang Hospital

location_facility: 8401108 - University of Missouri Health System

location_facility: 4400004 - Hospital of Lithuanian University of Health Sciences - Kauno Klinikos

location_facility: 3800129 - Azienda Ospedaliero-Universitaria Careggi

location_facility: 4100015 - Pusan National University Yangsan Hospital

location_facility: 8401128 - Hillcrest Family Health Center

location_facility: 0320033 - Corporacion Medica de San Martin

location_facility: 6160083 - Wojewódzki Szpital Specjalistyczny im. Marii Skłodowskiej-Curie

location_facility: 8040019 - Cherkasy Regional Cardiological Center

location_facility: 8400873 - Baptist Clinical Research Institute

location_facility: 2680027 - Tbilisi State Medical University (TSMU) - S. Khechinashvili

location_facility: 2760184 - Praxis Dr. Med. Nicole Toursarkissian

location_facility: 0760012 - Instituto de Cardiologia do Rio Grande do Sul

location_facility: 0760034 - Hospital e Maternidade Celso Pierro

location_facility: 1000058 - Multiprofile Hospital for Active Treatment Plovdiv AD

location_facility: 3000026 - University General Hospital Attikon

location_facility: 2680026 - Georgian-Dutch Hospital MEDISON

location_facility: 3480020 - Fejér Megyei Szent György Egyetemi Oktató Kórház

location_facility: 3920109 - National Hospital Organization Kumamoto Medical Center

location_facility: 1240081 - Saint Jerome Medical Research, Inc.

location_facility: 8400485 - V.A. North Texas Health Care System

location_facility: 3000016 - General Hospital of Thessaloniki "G. Papanikolaou"

location_facility: 8401157 - Memorial Health University Medical Center

location_facility: 2030038 - Vseobecna Fakultni Nemocnice, Ustav hematologie a krevni transfuze

location_facility: 2080021 - Amager and Hvidovre Hospital - Medical Department

location_facility: 0320073 - Instituto Medico De Alta Complejidad - IMAC

location_facility: 1700018 - Caja de Compensacion Familiar de Caldas

location_facility: 7920014 - Mersin Üniversitesi Tip Fakültesi

location_facility: 8401104 - Cardiovascular Institute of the South

location_facility: 6160095 - Centrum Kardiologii Inwazyjnej i Angiologii w Krośnie

location_facility: 7240053 - Hospital Universitari de Bellvitge (IDIBELL)

location_facility: 4100008 - Seoul National University Hospital

location_facility: 8400759 - Winchester Cardiology and Vascular Medicine

location_facility: 0760018 - Pronto Socorro Cardiológico de Pernambuco (PROCAPE)

location_facility: 2760193 - CardioVaskulares Centrum Frankfurt

location_facility: 0760052 - Hospital Nossa Senhora da Conceicao (HNSC)

location_facility: 1910008 - Specijalna Bolnica za Medicinsku Rehabilitaciju Krapinske Toplice

location_facility: 3920121 - Hokkaido Cardiovascular Hospital

location_facility: 4280005 - SIA Rigas Austrumu Kliniska Universitates Slimnica - Gaileze

location_facility: 8040017 - National Institute of Therapy named after L.T. Malaya NAMS o

location_facility: 8400904 - Northeast Iowa Medical Education Foundation

location_facility: 1240107 - Clinique de Cardiologie de Levis

location_facility: 7240077 - Hospital Universitari Arnau de Vilanova de Lleida

location_facility: 2760147 - GPR Klinikum Rüsselsheim II - Medizinische Klinik Innere Medizin

location_facility: 2760176 - Evangelisches Krankenhaus Witten

location_facility: 1580010 - China Medical University Hospital

location_facility: 6200018 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospitai

location_facility: 7240070 - Hospital Universitario Virgen Arrixaca

location_facility: 7920026 - Ondokuz Mayis Üniversitesi - Kardiyoloji Anabilim Dalı

location_facility: 0320069 - Hospital Italiano Regional del Sur

location_facility: 5780003 - Akershus Universitetssykehus HF

location_facility: 6160066 - IV Oddział Kardiologii Inwazyjnej, Elektrostymulacji i Angio

location_facility: 4840074 - Unidad de Investigación y Salud de Puebla S.C.

location_facility: 7920021 - Istanbul Universitesi Istanbul Tip Fakultesi

location_facility: 8400357 - Saint Luke's Boise Medical Center

location_facility: 7240047 - Parc Taulí Sabadell Hospital Universitari

location_facility: 8400557 - Clearwater Cardiovascular and Interventional Consultants

location_facility: 1000070 - University Multiprofile Hospital for Active Treatment Alexa

location_facility: 8401164 - University of Toledo Medical Center

location_facility: 2080014 - Svendborg Sygehus, Ward "Forskningsenheden Afd M Svendborg"

location_facility: 8400361 - Midwest Cardiovascular Research

location_facility: 8400625 - Michigan Heart and Vascular Institute

location_facility: 8400500 - Tennova Health Care - Turkey Creek Medical Center

location_facility: 6420053 - Spitalul Clinic Judetean de Urgenta Brasov

location_facility: 6420057 - Institutul de Boli Cardiovasculare "Prof. Dr. George I. M. Georgescu

location_facility: 6420052 - Spitalul Judeţean de Urgenţă "Dr. Constantin Opriş" Baia Mar

location_facility: 2500081 - CHU Besançon - Hôpital Jean Minjoz

location_facility: 1000053 - Multiprofile Hospital For Active Treatment - Pazardzhik AD

location_facility: 3800090 - Gruppo Ospedaliero San Donato - Policlinico San Marco

location_facility: 0760068 - Gutierrez Cardiologia Clinica e Intervencionista Ltda.

location_facility: 4840008 - Hospital Civil de Guadalajara - Nuevo Hospital Civil de Guadalajara

location_facility: 8400910 - Cardiovascular Innovation and Research Center

location_facility: 7640018 - Maharat Nakhon Ratchasima Hospital

location_facility: 5280058 - Universitair Medisch Centrum Utrecht

location_facility: 5280056 - Groene Hart Ziekenhuis - Gouda

location_facility: 6430110 - SBHI of Novosibirsk Region "City Clinical Hospital of Emergency Care #2"

location_facility: 1910013 - Klinički bolnički centar Sestre milosrdnice

location_facility: 2760130 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz

location_facility: 4580015 - Hospital Universiti Sains Malaysia

location_facility: 8400694 - University of California San Diego Medical Center

location_facility: 8400610 - Jesse Brown V.A. Medical Center

location_facility: 2500091 - CHRU Montpellier - Arnaud de Villeneuve

location_facility: 6430074 - St. Petersburg State Institution of Healthcare

location_facility: 3480029 - Békés Megyei Pándy Kálmán Kórház

location_facility: 6160093 - Specjalistyczny Szpital im. dr Alfreda Sokolowskiego

location_facility: 6160061 - Wojewódzki Szpital Zespolony im. Ludwika Rydygiera w Toruniu

location_facility: 8260093 - The London North West Healthcare NHS Trust - Northwick Park

location_facility: 8400577 - Doylestown Cardiology Associates

location_facility: 6880008 - Clinical Center of Serbia -- Division of Cardiology

location_facility: 6880019 - KBC "Dr Dragiša Mišović-Dedinje"

location_facility: 3760038 - Tel Aviv Sourasky Medical Center

location_facility: 3920120 - National Cerebral and Cardiovascular Center

location_facility: 0320044 - Instituto Medico de la Fundacion de Estudios Clínicos

location_facility: 5280054 - Noordwest Ziekenhuisgroep - Alkmaar

location_facility: 7020005 - National University Hospital (S) Pte Ltd

location_facility: 0560024 - Onze-Lieve-Vrouwziekenhuis VZW (OLV)

location_facility: 2080015 - Koege Sygehus - University Hospital Sjaelland

location_facility: 2030031 - Nemocnice Jablonec nad Nisou, p.o.

location_facility: 4100010 - The Catholic University of Korea, St. Vincent's Hospital


design_allocation: Randomized

intervention_type: Drug

status: Recruiting

study_start_date_type: Actual

study_type: Interventional

ipd_sharing_description:
Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent expert panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.

This trial data will be available according to the process described on www.clinicalstudydatarequest.com.

lead_sponsor: Novartis Pharmaceuticals

enrollment_type: Anticipated

primary_purpose: Treatment

location_country:
Peru
Guatemala
Jordan
Malaysia
Greece
Romania
Russian Federation
Taiwan
Iceland
India
France
Japan
Panama
Poland
Thailand
Norway
Argentina
Canada
Slovenia
Korea, Republic of
Colombia
South Africa
Chile
Hong Kong
Switzerland
Philippines
Vietnam
Bulgaria
Hungary
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Lebanon
Mexico
Czechia
Israel
Georgia
Spain
Turkey

acronym: Canopy-A

location_facility: Virginia Cancer Specialists Fairfax Northern Virginia

location_facility: Fort Wayne Medical Oncology/Hematology, Inc. Jefferson Blvd

location_facility: Cancer Center of Kansas Dept.ofCancerCtr.ofKansas

location_facility: Comprehensive Cancer Institute Comprehensive Cancer Instit

location_facility: Mercy Dignity Health of Greater Sacramento

location_facility: Rocky Mountain Cancer Centers Denver-Mdtn(Bone&MarrowTransp)

location_facility: VA Ann Arbor Health System VA Ann Arbor Health System

location_facility: Moanalua Medical Center. Attn: Oncology Dept

location_facility: Texas Oncology, P.A. Texas Oncology PA (3)

location_facility: Nebraska Cancer Specialists Regulatory Dept

location_facility: Texas Oncology, P.A. - Deke Slayton Cancer Center

location_facility: Oncology and Hematology Associates of Southwest Virginia Inc

location_facility: Chattanooga Oncology and Hematology Assoicates, PC Chattanooga Oncology

location_facility: Rush University Medical Center CLDT600AUS06

location_facility: Advanced Medical Specialties Drug Ship - 2

location_facility: Central Coast Medical Oncology Corporation Onc Dept

location_facility: VA Palo Alto Health Care System CRLX030A2301

location_facility: Louis Stokes Cleveland Department of Veterans Affairs MC

location_facility: VA Nebraska-Western Iowa Health Care System

location_facility: Kansas City VA Medical Center KCVA Med Ctr

location_facility: St. Jude Heritage Medical Group Virginia Crosson Cancer Center

location_facility: Los Angeles Hematology/Oncology Medical Group LA Cancer Network

location_facility: Durham VA Medical Center Durham VA Med Ctr -Station 558

location_facility: Cancer Care Centers of South Texas HOAST CCC of So. TX- San Antonio

location_facility: New York Oncology Hematology NYOH at Albany Medical Center

ipd_sharing: Undecided

study_completion_date_type: Anticipated

type: EudraCT Number

source: euctr

title: A Phase III, Multicenter, Randomized, Double Blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Canakinumab Versus Placebo as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II -IIIA and IIIB (T>5cm N2) Completely Resected (R0) Non-small Cell Lung Cancer (NSCLC)

summary: The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).

lead_sponsor_type: industriel

status_simplified: Ongoing


type: Registry Identifier

title: Prospective Non Interventional Study of Cabozantinib Tablets in Adults With Advanced Renal Cell Carcinoma Following Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Therapy

acronym: CASSIOPE

summary: The objective of this study is to understand the utilization of cabozantinib in subjects with advanced renal cell carcinoma (RCC) following prior VEGF-targeted therapy in real life settings in terms of dose modifications due to adverse events (AEs) when used as a second line therapy or third and later line therapy. Other patterns of use of cabozantinib will also be described.

study_type: Observational

time_perspective: Prospective

lead_sponsor: Ipsen

location_country:
Italy
Austria
Netherlands
France
Czechia
Greece
Poland
Belgium
Spain
Germany
United Kingdom

location_facility: Hospital na Bulovce, Institut of Radiation Oncology

location_facility: Azienda Ospedaliero-Universitaria di Parma

location_facility: University of Frankfurt - Department of Urology

location_facility: IRCCS Ospedale casa Sollievo Della Sofferenza

location_facility: Szpital Kliniczny Przemienienia Panskiego w Poznaniu

location_facility: Diakonissenkrankenhaus und Paulinenhilfe GGMBH

location_facility: Institut de Cancérologie Lucien Neuwirth (ICLN)

location_facility: Dep. Medical Oncology, University Hospital of Ioannina

location_facility: Krajská Nemocnice Liberec, A.S., Komplexní Onkologické Centrum

location_facility: East Kent Hospitals University NHS Foundation Trust

location_facility: National Cancer Institute "Fondazione G. Pascale" IRCCS

location_facility: Radiotherapy and Oncology Department FNKV

location_facility: Dept of Urology, Eberhard-Karls-University Tuebingen

location_facility: Frimley Health NHS Foundation Trust - Wezham Park and Heatherwood Hospitals

location_facility: Universitatsklinikum fur Urologie und Andrologie

location_facility: Azienda Ospedaliera Universitaria Integrata Verona

location_facility: Rosemere Cancer Centre, Royal Preston Hospital

location_facility: Thomayerova Nemocnice, Onkologická Klinika 1. LF UK A TN

location_facility: UOC Oncologia Azienda Ospedaliera Sant-Andrea

location_facility: Complejo Hospitalario Universitario de Compostela

location_facility: University Medical Center Hamburg-Eppendorf

location_facility: University Medical Center LMU Munich - Campus Grosshadern, Urologische Klinik und Poliklinik Marchionnish R. 15

location_facility: Klinikum Augsburg, II Medizinische Klinik, Hamatologie/Onkologie

location_facility: Hospital Universitario Central de Asturias (Huca)

location_facility: Wojskowy Instytut Medyczny, Klinika Onkologii

location_facility: Azienda Ospedaliero Universitaria di Modena

location_facility: Azienda Ospedaliera S.Orsola Malpighi di Bologna

intervention_type: Other


intervention_type: Device

lead_sponsor: Janssen Research & Development, LLC

location_country:
Greece
Australia
Belgium
Russian Federation
Denmark
Taiwan
Ukraine
France
Japan
Poland
Argentina
Canada
Korea, Republic of
Netherlands
Bulgaria
Hungary
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Israel
Spain
Turkey

acronym: THOR

location_facility: Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy

location_facility: Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval

location_facility: Zaporizhzhia medical Academy of postgraduate education, Zaporizhzhia Regoinal Clinical Hospital

location_facility: University Hospitals Bristol - Bristol Haematology & Oncolog

location_facility: I.M. Sechenov First Moscow State Medical University

location_facility: Privolzhsky District Medical Center under the Federal Medico-Biological Agency

location_facility: Russian Scientific Center of Roentgenoradiology

location_facility: State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center

location_facility: 'Papageorgiou' General Hospital of Thessaloniki

location_facility: Multiprofile Hospital for Active Treatment 'Sveta Marina' EAD

location_facility: Multiprofile Hospital for Active Treatment 'Tokuda Hospital Sofia'

location_facility: Istituto Oncologico Veneto Iov Irccs Padova

location_facility: Saskatchewan Cancer Agency (SCA) - Allan Blair Cancer Centre

location_facility: Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4

location_facility: Städtisches Klinikum Braunschweig gGmbH-Klinik für Urologie und Uroonkologie

location_facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

location_facility: Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council

location_facility: Institut Català D'Oncologia-Hospital Universitari Germans Trias I Pujol

location_facility: Universitatsklinikum Carl Gustav Carcus Dresden

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie

location_facility: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

location_facility: Kobe City Medical Center General Hospital

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: Medizinische Fakultät Mannheim der Universität Heidelberg

location_facility: University of Miami/Sylvester Cancer Center

location_facility: Fondazione Policlinico Universitario A. Gemelli IRCCS

location_facility: Shengjing Hospital of China Medical University

location_facility: Peninsula & South Eastern Haematology and Oncology Group

location_facility: University of California Irvine Medical Center - Chao Family Comprehensive Cancer Center

location_facility: Policlinico Hospital San Martino- IRCCS for Oncology

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: Institut de Cancérologie de l'Ouest (ICO)

location_facility: Levine Cancer Institute, Carolinas HealthCare System

location_facility: St. Helena Hospital - Martin-O'Neil Cancer Center

location_facility: The First Affliated Hospital Of Nanchang University

location_facility: Associação Mário Penna/Núcleo de Ensino e Pesquisas

location_facility: Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Presidio Spedali Civili

location_facility: Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria

location_facility: Chang-Gung Memorial Hospital, LinKou Branch

location_facility: The Christie NHS Foundation Trust - Christie Hospital

location_facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz

location_facility: Fundacao Pio Xii - Hospital De Cancer De Barretos

location_facility: UOC Oncologia Ospedale Provinciale di Macerata

location_facility: Instituto de Oncologia de Sorocaba/Onco Clinicas Especializadas

location_facility: Oncologia Medica-Città Della Salute E Della Scienza Di Torino

location_facility: University General Hospital of Rio Patras

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: LKH - Universitätsklinikum der PMU Salzburg

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: First Affiliated Hospital of Wenzhou Medical College

location_facility: First Affiliated Hospital, Xi'an Jiaotong University

location_facility: National Medical Radiological Research Center

location_facility: Koo Foundation Sun Yat-Sen Cancer Center

location_facility: Thunder Bay Regional Health Sciences Centre

location_facility: GBUZ Oncology Centre #2 of Healthcare Department of Krasno

location_facility: Inonu Universitesi Turgut Ozal Tip Merkezi, Ic Hastaliklari

location_facility: Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'

location_facility: Saint-Petersburg Clinical Scientific And Practical Center For Special Types Of Medical Care

location_facility: T.C. Saglik Bakanlıgi Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi

location_facility: Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria alle Scotte

location_facility: University of Pittsburgh Medical Center (UPMC)

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: The First Bethune Hospital of Jilin University

location_facility: Sociedade Beneficiante de Senhoras - Hospital Sirio Libanes

location_facility: Kliniken Nordoberpfalz AG/Klinikum Weiden

location_facility: MI Dnipropetrovsk Region Clinical Hospital n a I.I.Mechnikov

location_facility: Centre de radiothérapie et d'Oncologie médicale de l'Essonne

location_facility: Irmandade da Santa Casa de Misericordia de Porto Alegre

location_facility: ALTHAIA, Xarxa Assistencial Universitària de Manresa

location_facility: Centro de Pesquisas do Hospital Amaral Carvalho

location_facility: Universitätsklinikum Schleswig Holstein Campus Lübeck

location_facility: Russian Scientific Center of Radiology and Surgical Technologies

location_facility: University Of UA Cancer Center(UACC)/DH-SJHMC

location_facility: Guangzhou First Municipal People's Hospital

location_facility: Seoul National University Bundang Hospital

location_facility: Izmir Katip Celebi University Ataturk Training and Research Hospital

location_facility: Usl 7 Siena - Ospedale Alta Valdelsa ASL TOSCANA SUD-EST

location_facility: University of Athens Medical School - Regional General Hospi

location_facility: Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás

location_facility: Multifunctional clinical medical center 'Medical city'

location_facility: Municipal non-profit enterprise 'Regional Center of Oncology'

location_facility: GBUZ of Stavropol region Pyatigorsk Oncological Dispensary

location_facility: The Center for Cancer and Blood Disorders

location_facility: Azienda Ospedaliero - Universitaria Ospedali Riuniti

location_facility: Centro Estatal de Cancerología de Chihuahua

location_facility: Országos Onkológiai Intézet, Urogenitális Tumorok és Klinikai Farmakológiai Osztály

location_facility: Derriford Hospital-Department of Medical Oncology

location_facility: Dokkyo Medical University Saitama Medical Center

location_facility: FSBSI 'N. N. Blokhin Russian Cancer Research Center'

location_facility: Tokyo Women's Medical University Hospital

location_facility: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

location_facility: Baskent University Adana Practice and Research Center Kisla Health Campus

location_facility: Hospital Das Clinicas Da Universidade Federal De Minas Gerais

location_facility: Huadong Hospital Affiliated to Fudan University

location_facility: Friedrich-Alexander Universitaet Urologische Universitaetskl

location_facility: Cancer Hospital Chinese Academy of Medical Sciences

location_facility: University of Calif Davis Medical Center

location_facility: FGBOU Vo Mordovian National Research State University N. A. N.P. Ogareva

location_facility: Cemaic - Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica

location_facility: Private Medical Institution Euromedservice

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine

location_facility: Hospital de Base de São José do Rio Preto

location_facility: INOVA Dwiight &Martha Schar Cancer Institute

location_facility: Pavlov First Saint Petersburg State Medical University

location_facility: Institut Regional du Cancer de Montpellier Val d'Aurelle

location_facility: Azienda Ospedaliero Universitaria Pisana

location_facility: Istituti Ospitalieri di Cremona, AO di Cremona

location_facility: Transkarpathian Regional University Oncology Clinic

location_facility: Rabin Medical Center, Beilinson Hospital

location_facility: H. Santa Maria - Centro Hospitalar de Lisboa Norte

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz

location_facility: Instituto D'Or de Pesquisa e Ensino (IDOR)

location_facility: National Hospital Organizaiton Shikoku Cancer Center

location_facility: Ist. Clinici Scientifici Maugeri - Unità Operativa di Oncolo

location_facility: Uniwersytecki Szpital Kliniczny we Wrocławiu

location_facility: Ibcc - Instituto Brasileiro de Controle Do Cancer

location_facility: Alaska Urological Institute dba Alaska Clinical Research Center

location_facility: National Hospital Organization Hokkaido Cancer Center

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine

location_facility: Champalimaud Foundation Champalimaud Centre

type: Other Identifier

title: A Phase 3 Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Subjects With Advanced Urothelial Cancer and Selected FGFR Gene Aberrations

summary: The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent (cohort 1) or 1 prior treatment not containing an anti-PD-(L) 1 agent (cohort 2).


ReferenceType: derived

ReferenceCitation: Young B, Tan TT, Leo YS. The place for remdesivir in COVID-19 treatment. Lancet Infect Dis. 2021 Jan;21(1):20-21. doi: 10.1016/S1473-3099(20)30911-7. Epub 2020 Nov 26.

family: Young

full_name: Barnaby Young

given: Barnaby

sequence: first

family: Tan

full_name: Thuan Tong Tan

given: Thuan Tong

sequence: additional

family: Leo

full_name: Yee Sin Leo

given: Yee Sin

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: The Lancet Infectious Diseases

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via free pdf)

host_type: publisher

license_normalized: no license

version: publishedVersion

evidence: oa repository (via pmcid lookup)

host_type: repository

repository_normalized: PubMed Central

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

status: Terminated

enrollment_type: Actual

location_country:
Peru
Malaysia
Australia
Belgium
Russian Federation
Taiwan
Ukraine
India
France
Poland
Lithuania
Slovakia
Thailand
Argentina
Canada
Korea, Republic of
South Africa
Chile
Sweden
Netherlands
Vietnam
Bulgaria
Singapore
Hungary
China
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Czechia
Israel
New Zealand
Spain
Turkey
Latvia

location_facility: Siauliai Republican Hospital, Public Institution

location_facility: Hospital Privado Centro Medico de Cordoba

location_facility: Hospital Infantil de Mexico Federico Gomez

location_facility: Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

location_facility: The Third Xiangya Hospital, Central South University

location_facility: Irmandade Da Santa Casa de Misericordia de Sao Paulo

location_facility: Karadeniz Teknik University Medical Faculty

location_facility: Hospital Nuestra Señora de la Misericordia

location_facility: Hallym University Dongtan Sacred Heart Hospital

location_facility: The Catholic University of Korea St. Vincent's Hospital

location_facility: Department for Heart Failure and Valvular Disease

location_facility: The Catholic University of Korea, Incheon St. Mary's Hospital

location_facility: Western Michigan University Homer Stryker M.D. School of Medicine Center for Clinical Research

location_facility: Suretech Hospital and Research Centre Limited

location_facility: Azienda Ospedaliera Universitaria Maggiore della Carità

location_facility: Azienda Socio Sanitaria Territoriale di Monza Presidio San Gerardo

location_facility: Centre of Tuberculosis and Lung Diseases

location_facility: Nemocnica arm. generala L. Svobodu Svidnik, a.s.,

location_facility: Nemocnica s poliklinikou S. Kukuru Michalovce, a.s.

location_facility: Miller Children's at Long Beach Medical Center

location_facility: CEMIC (Centro de Educación Médica e Investigaciones Clínicas)

location_facility: Santa Casa de Misericordia de Belo Horizonte

location_facility: Health Sciences North Horizon Sante-Nord

location_facility: Hallym University Kangnam Sacred Heart Hospital

location_facility: Multiprofile Hospital for Active Treatment - MHAT Lyulin EAD

location_facility: Rajiv Gandhi Institute of Medical Sciences

location_facility: Clinical Research Centre University of Cape Town

location_facility: Pauls Stradins Clinical University Hospital

location_facility: Hospital Civil de Guadalajara Fray Antonio Alcalde

location_facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

location_facility: Fondazione IRCCS Ospedale Maggiore Policlinico,Mangiagalli e Regina Elena

location_facility: NZOZ Centrum Badań Klinicznych,Piotr Napora,Lekarze Spółka Partnerska

location_facility: Ospedale San Raffaele- Sede Distaccata Ospedale S. Raffaele Turro

location_facility: Taipei Medical University-Wan Fang Hospital

location_facility: SMZ Süd - Kaiser Franz Josef Spital Wien

location_facility: Azienda Ospedaliera Universitaria Integrata Verona

location_facility: Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

location_facility: Fortis Flight Lieutenant Rajan Dhall Hospital

location_facility: Hospital Civil de Guadalajara Dr. Juan I. Menchaca

location_facility: ASST Grande Ospedale Metropolitano Niguarda

location_facility: Ospedale San Giuseppe - Fatebenefratelli

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre - Hospital da Crianca Santo Antonio

location_facility: Centre Hospitalier Intercommunal de Créteil

location_facility: Hospital de Medicina de São José do Rio Preto

location_facility: Bamrasnaradura Infectious Disease Institute

location_facility: Social Medizinisches Zentrum Baumgartner Höhe - Otto Wagner Spital

location_facility: Poltava Regional Clinical Hospital HSEI of Ukraine Ukrainian Medical Stomatological Academy

location_facility: CHU de Grenoble - Hôpital Albert Michallon

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

location_facility: Kharkiv MA of PGE Ch of inf.dis. BO Kharkiv Reg.Cl.inf.Hosp.

location_facility: Universitaetsklinikum Giessen und Marburg GmbH

location_facility: Fifth Multiprofile Hospital for Active Treatment - MHAT - Sofia EAD

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: Hospital Interzonal General de Agudos Dr. Jose Penna

location_facility: Clinical Infectious Diseases Hospital n. a. S.P. Botkin

location_facility: Hospital Universitario 'Dr. Jose Eleuterio Gonzalez'

location_facility: Communal Institution Central City Hospital

location_facility: University of Texas Southwestern Medical Center

location_facility: Infectious Diseases Center of Vilnius University Hospital Santaros klinikos

study_completion_date_type: Actual

title: A Phase 3 Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Patients With Influenza A Infection

summary: The purpose of this study is to evaluate the clinical and virologic benefit of pimodivir in combination with Standard-of-Care (SOC) treatment compared to placebo in combination with SOC treatment.

status_simplified: Unknown


title: Improvement of Outcome in Elderly Patients or Patients Not Eligible for High-dose Chemotherapy With Aggressive NHL in First Relapse/Progression by Adding Nivolumab to Gemcitabine, Oxaliplatin Plus Rituximab in Case of B-cell Lymphoma

acronym: NIVEAU

summary: This study evaluates the addition of nivolumab to gemcitabine, oxaliplatin plus rituximab in case of B-cell lymphoma

lead_sponsor: Universität des Saarlandes

location_country: Austria Netherlands France Poland Israel Belgium Portugal Germany

location_facility: Samodzielny Publiczny Zakład Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie

location_facility: Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre

location_facility: Marien Kliniken Siegen, Klinik für Hämatologie, Medizinische Onkologie und Palliativmedizin

location_facility: BAG Freiberg-Richter, Jacobasch, Wolf, Illmer

location_facility: Krankenhaus der Barmherzigen Brüder, I. Med. Abteilung

location_facility: UNIVERSITE CATHOLIQUE DE LOUVAIN MONT GODINNE - Hematology

location_facility: Schwarzwald-Baar Klinikum, Innere Medizin II

location_facility: CHU de Montpellier - Hématologie Clinique

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr. 1

location_facility: CHU Dijon - Hôpital d'Enfants - Hématologie Clinique

location_facility: CHU de Bordeaux - Hôpital Haut Lévêque - Centre François Magendie

location_facility: Universitätsklinik für Innere Medizin I, AKH Wien

location_facility: Klinikum der Universität München, Med. Klinik und Poliklinik III

location_facility: Universitätsklinikum des Saarlandes, Innere Med. I

location_facility: Stauferklinikum Schwäbisch Gmünd, Zentrum für Innere Medizin

location_facility: CHU Nancy - Hôpital de Brabois - Service d'Hématologie et Médecine Interne

location_facility: Medizinische Hochschule Hannover, Klinik für Hämatologie

location_facility: Uniklinikum Ulm, Klinik für Innere Medizin III

location_facility: Ordensklinikum Linz - Krankenhaus der Barmherzigen Schwestern Linz

location_facility: Klinikum Stuttgart, Klinik für Hämatologie

location_facility: St. Vincentius Kliniken Karlsruhe, Med. Klinik Abt. 2

location_facility: Universitätsmedizin Göttingen, Klinik für Hämatologie

location_facility: Westpfalz-Klinikum, Klinik für Innere Medizin I

location_facility: Marie Sklodowska-Curie Institute and Oncology

location_facility: Gemeinschaftspraxis Dres. Mohm, Prange-Krex

location_facility: Klinikum Mutterhaus der Borromäerinnen, Med. Abteilung I

location_facility: CH Départemental Vendée - Onco-Hématologie

location_facility: St. Antonius-Hospital Eschweiler, Klinik für Hämatologie

location_facility: CHU de Grenoble - Hôpital Albert Michallon - Hématologie Clinique

location_facility: Universitätsklinikum Regensburg, Klinik für Innere Medizin III

location_facility: CHU de Nantes - Hôtel Dieu - Hématologie

location_facility: Institut de Cancèrologie Lucien Neuwirth

location_facility: Charité - Universitätsklinikum Berlin, Med. Klinik m. S. Hämatologie

location_facility: Uni Gießen und Marburg, Klinik für Hämatologie

location_facility: CHU Côte de Nacre - Service Hématologie Clinique

location_facility: The Chaim Sheba Medical Center - Division of Hematology and Bone-Marrow Transplantation

location_facility: Universitätsklinikum Haale (Saale), Klinik für Innere Medizin IV

location_facility: UNIVERSITE CATHOLIQUE DE LOUVAIN SAINT-LUC - Hematology

location_facility: Instituto Português Oncologia - Hematology

location_facility: Hôpital Henri Mondor - Unité "Hémopathies Lymphoïdes" - HDJ 11è

location_facility: Universitätsmedizin Rostock, Klinik für Hämatologie

location_facility: Universitätsklinikum Tübingen, Innere Medizin II

location_facility: Kepler Universitätsklinikum GmbH- Med. Campus III

location_facility: UNIVERSITAIR ZIEKENHUIS GENT - Hematology

location_facility: Universitätsklinikum Essen, Klinik für Hämatologie

location_facility: Vivantes Klinikum am Urban, Klinik für Innere, Hämatologie und Onkologie

lead_sponsor_type: academique


ReferenceCitation: Johnston SC, Amarenco P, Aunes M, Denison H, Evans SR, Himmelmann A, Jahreskog M, James S, Knutsson M, Ladenvall P, Molina CA, Nylander S, Röther J, Wang Y; THALES Investigators. Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. Stroke. 2021 Nov;52(11):3482-3489. doi: 10.1161/STROKEAHA.121.035555. Epub 2021 Sep 3.

name: Dean's Office, Dell Medical School, University of Texas, UNITED STATES

family: Johnston

full_name: S. Claiborne Johnston

given: S. Claiborne

name: Neurology and Stroke Center, Bichat Hospital and Medical School, FRANCE

family: Amarenco

full_name: Pierre Amarenco

given: Pierre

name: CVMD TA GRAPSQA, AstraZeneca R&D, SWEDEN

family: Aunes

full_name: Maria Aunes

given: Maria

family: Denison

full_name: Hans Denison

given: Hans

name: Biostatistics Center, George Washington University, UNITED STATES

family: Evans

full_name: Scott Evans

given: Scott

name: Global Medicines Development, AstraZeneca, SWEDEN

family: Himmelmann

full_name: Anders Himmelmann

given: Anders

family: Jahreskog

full_name: Marianne Jahreskog

given: Marianne

name: Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, SWEDEN

family: James

full_name: Stefan James

given: Stefan

name: Biometrics, BioPharmaceuticals R&D, AstraZeneca, SWEDEN

family: Knutsson

full_name: Mikael Knutsson

given: Mikael

name: Biopharmaceuticals R&D, AstraZeneca, SWEDEN

family: Ladenvall

full_name: Per Ladenvall

given: Per

name: Neurology, Hospital Vall d'Hebron, SPAIN

family: Molina

full_name: Carlos A. Molina

given: Carlos A.

name: Translational Sciences, AstraZeneca R&D Sweden, SWEDEN

family: Nylander

full_name: Sven Nylander

given: Sven

name: Department of Neurology, Asklepios Klinik Altona Hamburg, GERMANY

family: Röther

full_name: Joachim Röther

given: Joachim

name: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases, CHINA

family: Wang

full_name: Yongjun Wang

given: Yongjun

journal_name: Stroke

evidence: open (via page says license)

license: cc-by

license_normalized: cc-by

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

title: Ischemic Benefit and Hemorrhage Risk Of Ticagrelor-Aspirin Versus Aspirin In Patients With Acute Ischemic Stroke Or TIA

ReferenceCitation: Wang Y, Pan Y, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Birve F, Ladenvall P, Molina CA, Johnston SC; THALES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke: An Exploratory Analysis of the THALES Randomized Clinical Trial. JAMA Neurol. 2021 Sep 1;78(9):1091-1098. doi: 10.1001/jamaneurol.2021.2440.

name: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

name: China National Clinical Research Center for Neurological Diseases, Beijing, China

family: Pan

full_name: Yuesong Pan

given: Yuesong

family: Li

full_name: Hao Li

given: Hao

name: Department of Neurology and Stroke Center, Bichat–Claude Bernard Hospital, University of Paris, Paris, France

name: Biopharmaceuticals Research and Development, AstraZeneca, Gothenburg, Sweden

name: Department of Medical Sciences, Uppsala University, Uppsala, Sweden

name: Stroke Unit, Vall d’Hebron Hospital, Barcelona, Spain

name: for the THALES Steering Committee and Investigators

name: THALES Steering Committee and Investigators

ReferenceCitation: Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial. Stroke. 2021 Jul;52(7):2414-2417. doi: 10.1161/STROKEAHA.121.034089. Epub 2021 May 4.

name: NYU Grossman School of Medicine, NY (S.Y., S.R., A.K.).

name: Department of Neurology, NYU Langone Health, NY (S.Y., S.R., A.K.).

name: Department of Neurology, University of Utah Medical Center, Salt Lake City (A.d.H.).

name: Department of Neurology, Duke University, Durham, NC (B.M.G.).

name: Department of Neurology, Brown University, Providence, RI (K.L.F.).

name: Department of Neurology, University of California, San Francisco (A.S.K., J.D.E.).

name: Dean’s Office, Dell Medical School, The University of Texas at Austin (S.C.J.).

name: Department of Neurology and Department of Psychiatry, University of Massachusetts Medical Center, Worcester (N.H.).

title: Carotid Stenosis and Recurrent Ischemic Stroke

ReferenceCitation: Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators*. Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin. Stroke. 2020 Dec;51(12):3504-3513. doi: 10.1161/STROKEAHA.120.032239. Epub 2020 Nov 16.

name: Department of Neurology and Stroke Center, Bichat University Hospital, University of Paris, France (P.A.).

repository_institution: University of Melbourne - Minerva Access

repository_normalized: University of Melbourne - Minerva Access

repositories: University of Melbourne - Minerva Access

repositories_institution: University of Melbourne - Minerva Access

ReferenceCitation: Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators. Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial. JAMA Neurol. 2020 Nov 7. doi: 10.1001/jamaneurol.2020.4396. [Epub ahead of print] Erratum in: JAMA Neurol. 2021 Feb 1;78(2):253.

name: Department of Neurology and Stroke Center, Bichat University Hospital, University of Paris, Paris, France

name: AstraZeneca, Biopharmaceuticals R&D, Gothenburg, Sweden

name: Biostatistics Center, The George Washington University, Washington, DC

name: Stroke Unit, Hospital Vall d’Hebron, Barcelona, Spain

name: Department of Neurology, Tiantan Hospital, Beijing, China

repository_institution: Uppsala University - Uppsala University Publications

repositories_institution: Uppsala University - Uppsala University Publications

ReferenceCitation: Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020 Jul 16;383(3):207-217. doi: 10.1056/NEJMoa1916870.

name: From the Dean’s Office, Dell Medical School, University of Texas at Austin, Austin (S.C.J.); the Department of Neurology and Stroke Center, Bichat–Claude Bernard Hospital, University of Paris, Paris (P.A.); Biopharmaceuticals Research and Development, AstraZeneca, Gothenburg (H.D., A.H., M.K., P.L.), and the Department of Medical Sciences, Uppsala University, Uppsala (S.J.) — both in Sweden; the Biostatistics Center, George Washington University, Washington, DC (S.R.E.); the Stroke Unit, Vall d’Hebron...

ReferenceCitation: Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design. Int J Stroke. 2019 Oct;14(7):745-751. doi: 10.1177/1747493019830307. Epub 2019 Feb 12.

name: Dell Medical School, University of Texas at Austin, Austin, TX, USA

name: Department of Neurology and Stroke Centre, Bichat Hospital, Paris Diderot, Paris, France

name: Biostatistics Center, George Washington University, Washington DC, MD, USA

name: Stroke Unit, Hospital Vall d'Hebron, Barcelona, Spain

name: Department of Neurology, Beijing Tiantan Hospital, Beijing, China

ReferenceCitation: Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18.

name: From the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin (K.S.L.W.)

name: Department of Neurology and Stroke Centre, Bichat Hospital, Paris Diderot University, France (P.A.)

name: Stanford Stroke Center, Stanford University, CA (G.W.A.)

name: Global Medicines Development, AstraZeneca, Gothenburg, Sweden (H.D., P.H., A.H., M.K., P.L.)

name: Department of Neurology, University of California, San Francisco (J.D.E.)

name: Department of Biostatistics, Harvard University, Boston, MA (S.R.E.)

name: Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.)

name: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (K.M.)

name: Stroke Unit, Hospital Vall d’Hebron, Barcelona, Spain (C.A.M.)

name: Department of Neurology, Beijing Tiantan Hospital, China (Y.W.)

name: Dean’s Office, Dell Medical School, University of Texas at Austin (S.C.J.).

name: for the SOCRATES Steering Committee and Investigators

location_country:
Peru
Romania
Belgium
Australia
Russian Federation
Taiwan
Ukraine
India
France
Poland
Thailand
Slovakia
Argentina
Canada
Korea, Republic of
Sweden
Saudi Arabia
Hong Kong
Vietnam
Bulgaria
Hungary
China
Germany
Italy
Brazil
Mexico
Czechia
Spain

title: A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared With ASA in the Prevention of Stroke and Death in Patients With Acute Ischaemic Stroke or Transient Ischaemic Attack

summary: Study to investigate if the study drug ticagrelor and ASA is more effective than Placebo (inactive tablet) and ASA in preventing new stroke events


title: Atezolizumab in Combination With Bevacizumab and Chemotherapy Versus Bevacizumab and Chemotherapy in Recurrent Ovarian Cancer - a Randomized Phase III Trial

summary: This is a phase III, randomized, partially blinded, multicenter trial to evaluate the efficacy and safety of atezolizumab plus bevacizumab and chemotherapy compared to placebo plus bevacizumab and chemotherapy in patients with recurrent ovarian-, fallopian tube, or primary peritoneal cancer with 1st or 2nd relapse within 6 months after platinum based chemotherapy or 3rd relapse.

ReferenceCitation: Harter P, Pautier P, Van Nieuwenhuysen E, Reuss A, Redondo A, Lindemann K, Kurzeder C, Petru E, Heitz F, Sehouli J, Degregorio N, Wimberger P, Burges A, Cron N, Ledermann J, Lorusso D, Paoletti X, Marme F. Atezolizumab in combination with bevacizumab and chemotherapy versus bevacizumab and chemotherapy in recurrent ovarian cancer - a randomized phase III trial (AGO-OVAR 2.29/ENGOT-ov34). Int J Gynecol Cancer. 2020 Dec;30(12):1997-2001. doi: 10.1136/ijgc-2020-001572. Epub 2020 Jun 30.

family: Harter

full_name: Philipp Harter

given: Philipp

family: Pautier

full_name: Patricia Pautier

given: Patricia

family: Van Nieuwenhuysen

full_name: Els Van Nieuwenhuysen

given: Els

family: Reuss

full_name: Alexander Reuss

given: Alexander

family: Redondo

full_name: Andres Redondo

given: Andres

family: Lindemann

full_name: Kristina Lindemann

given: Kristina

family: Kurzeder

full_name: Christian Kurzeder

given: Christian

family: Petru

full_name: Edgar Petru

given: Edgar

family: Heitz

full_name: Florian Heitz

given: Florian

family: Sehouli

full_name: Jalid Sehouli

given: Jalid

family: Degregorio

full_name: Nikolaus Degregorio

given: Nikolaus

family: Wimberger

full_name: Pauline Wimberger

given: Pauline

family: Burges

full_name: Alexander Burges

family: Cron

full_name: Nadin Cron

given: Nadin

family: Ledermann

full_name: Jonathan Ledermann

given: Jonathan

family: Lorusso

full_name: Domenica Lorusso

given: Domenica

family: Paoletti

full_name: Xavier Paoletti

given: Xavier

family: Marme

full_name: Frederik Marme

given: Frederik

journal_name: International Journal of Gynecologic Cancer

oa_host_type: repository

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: University College London - UCL Discovery

repository_normalized: UCL Discovery

version: submittedVersion

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

title: Atezolizumab in combination with bevacizumab and chemotherapy versus bevacizumab and chemotherapy in recurrent ovarian cancer – a randomized phase III trial (AGO-OVAR 2.29/ENGOT-ov34)

lead_sponsor: AGO Research GmbH

location_country: Austria Sweden Switzerland Finland France Lithuania Norway Belgium Spain Estonia Denmark Germany

location_facility: Hospital Clínico Universitario de Valencia

location_facility: IUCT Oncopole - Institut Claudius Regaud

location_facility: Medizinische Universität Wien (MUW) Universitätsklinik für Frauenheilkunde

location_facility: Vilniaus universiteto ligoninė Santaros klinikos

location_facility: Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie

location_facility: Medizinische Universiät Graz (MUG), Universitätsklinik für Gynäkologie und Geburtshilfe

location_facility: Hospital General Universitario Morales Meseguer

location_facility: Kepler Universitäts Klinikum (KUK), Universitätsklinik für Gynäkologie

location_facility: Mammazentrum Hamburg am Krankenhaus Jerusalem

location_facility: Institut Català d'Oncologia (ICO) d'Hospitalet

location_facility: Institut Català d'Oncologia (ICO) de Girona

location_facility: Charité - Universitätsmedizin Berlin (CVK)

location_facility: Groupe Hospitalier Diaconesses Croix Saint Simon

location_facility: Praxisgemeinschaft Frauenärzte am Bahnhofsplatz

location_facility: Hospital Regional Universitario de Málaga

location_facility: Blois Hospital (Centre Hospitalier de Blois)

location_facility: Institut de Cancérologie Lucien Neuwirth

location_facility: SASU Centre d'Oncologie et Radiothérapie 37

location_facility: Vall d'Hebron Instituto de Oncología (VHIO)

location_facility: Copenhagen University Hospital, Rigshospitalet


title: An International, Phase 3, Open-Label, Randomized Study of BGB-3111 Compared With Bendamustine Plus Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (CLL/SLL)

acronym: SEQUOIA

summary: To compare efficacy between zanubrutinib versus bendamustine and rituximab in patients with previously untreated CLL/SLL, as measured by progression free survival.

ReferenceType: result

ReferenceCitation: Mu S, Tang Z, Novotny W, Tawashi M, Li TK, Ou Y, Sahasranaman S. Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects. Cancer Chemother Pharmacol. 2020 Feb;85(2):391-399. doi: 10.1007/s00280-019-04015-w. Epub 2019 Dec 26.

family: Mu

full_name: Song Mu

given: Song

family: Tang

full_name: Zhiyu Tang

given: Zhiyu

family: Novotny

full_name: William Novotny

given: William

family: Tawashi

full_name: Manal Tawashi

given: Manal

family: Li

full_name: Ta-Kai Li

given: Ta-Kai

family: Ou

full_name: Ying Ou

given: Ying

family: Sahasranaman

full_name: Srikumar Sahasranaman

given: Srikumar

journal_name: Cancer Chemotherapy and Pharmacology

evidence: open (via crossref license)

evidence: oa repository (via OAI-PMH doi match)

repository_institution: PubMed Central - Europe PMC

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer

ReferenceCitation: Tam CS, Robak T, Ghia P, Kahl BS, Walker P, Janowski W, Simpson D, Shadman M, Ganly PS, Laurenti L, Opat S, Tani M, Ciepluch H, Verner E, Šimkovič M, Österborg A, Trněný M, Tedeschi A, Paik JC, Kuwahara SB, Feng S, Ramakrishnan V, Cohen A, Huang J, Hillmen P, Brown JR. Zanubrutinib monotherapy for patients with treatment naïve chronic lymphocytic leukemia and 17p deletion. Haematologica. 2020 Oct 13;106(9):2354-2363. doi: 10.3324/haematol.2020.259432.

family: Tam

full_name: Constantine S. Tam

given: Constantine S.

family: Robak

full_name: Tadeusz Robak

given: Tadeusz

family: Ghia

full_name: Paolo Ghia

given: Paolo

family: Kahl

full_name: Brad S. Kahl

given: Brad S.

family: Walker

full_name: Patricia Walker

family: Janowski

full_name: Wojciech Janowski

given: Wojciech

family: Simpson

full_name: David Simpson

given: David

family: Shadman

full_name: Mazyar Shadman

given: Mazyar

publisher: Ferrata Storti Foundation (Haematologica)

title: Zanubrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia and 17p deletion

location_country:
Italy
Austria
Sweden
Spain
France
Czechia
Poland
Australia
Belgium
New Zealand
Russian Federation
United States
United Kingdom
Taiwan

location_facility: Wojewódzki Szpital Specjalistyczny w Legnicy

location_facility: Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

location_facility: Cambridge University Hospitals NHS Foundation Trust

location_facility: Centre Hospitalier Victor Dupouy d'Argenteuil

location_facility: City Clinical Hospital No. 52 of the Moscow Healthcare Department

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

location_facility: FGU Russian Scientific Research Institute of Hematology and Transfusiology

location_facility: Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi

location_facility: Centre Hospitalier Régional et Universitaire de Tours Hôpital Bretonneau

location_facility: The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust

location_facility: Centre Hospitalier Universitaire Limoges CHU de Limoges

location_facility: Azienda Ospedaliera Universitaria San Martino

location_facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino

location_facility: Fakultní Nemocnice Hradec Králové - Ústav Klinické Imunologie a Alergologie

location_facility: East Kent Hospitals University NHS Foundation Trust

location_facility: N. N. Blokhin Russian Cancer Research Center

location_facility: Taipei Medical University - Shuang Ho Hospital

location_facility: Fondazione Policlinico Universitario Agostino Gemelli

location_facility: Municipal Healthcare Institution "Clinical Medical Sanitary Establishment #1"

location_facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

location_facility: Krankenhaus der Barmherzigen Schwestern Linz

location_facility: Szpitale Pomorskie Spółka z ograniczoną odpowiedzialnością

location_facility: Centre Hospitalier Universitaire Universite Catholique de Louvain Site Godinne

location_facility: Nizhniy Novgorod Regional Clinical Hospital N.A.

location_facility: Cliniques du Sud-Luxembourg Site Clinique Saint-Joseph

location_facility: Institut Català d'Oncologia - L'Hospitalet de Llobregat

location_facility: Centre Hospitalier Universitaire Nantes - Hotel Dieu

location_facility: Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

location_facility: Sverdlovsk Regional Clinical Hospital #1

location_facility: Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev

location_facility: Sahlgrenska Universitetssjukhuset, Östra sjukhuset

location_facility: Karolinska Universitetssjukhuset - Solna

location_facility: City Hospitals Sunderland NHS Foundation Trust

location_facility: Centre Hospitalier Universitaire de Poitier- Hopital de la Miletrie - Hopital Jean Bernard

location_facility: Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois

location_facility: State Healthcare Institution Oncologic Dispensary No. 2 - Health Department of Krasnodar Region

location_facility: VA Puget Sound Health Care System, Pathology and Laboratory Medicine Services 113

location_facility: Centre Hospitalier Universitaire (CHU) de Liège - Site du Sart Tilman

location_facility: Universita degli Studi di Roma "La Sapienza" - Umberto I Policlinico di Roma

location_facility: Azienda Ospedaliera Santa Maria di Terni

location_facility: Samodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali Miejskich

location_facility: Universita Degli Studi di Modena-Azienda Ospedaliere Policlinco

location_facility: State Budgetary Healthcare Institution "Volgograd Regional Clinical Oncology Dispensary #1"

location_facility: Presidio Ospedaliero di Gardone Val Trompia

location_facility: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

location_facility: Joe Arrington Cancer Research and Treatment Center

location_facility: Nottingham University Hospitals NHS Trust

location_facility: Azienda Unita Sanitaria Locale di Ravenna

location_facility: Copernicus Podmiot Leczniczy Wojewódzkiego Centrum Onkologii

location_facility: Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza

location_facility: Universitätsklinik für Innere Medizin Salzburg