title: Caractérisation et détection Des Mouvements Durant Les Crises d'épilepsie à Des Fins d'Alarme, Pour un Usage en Institution et en Famille.

summary:
CAPAMETRIM 2 aims to characterize epileptic motor patterns by a quantitative three-dimensional analysis of movements.

This is done to obtain a 3-D motor signature of seizures, for a given patient, and allows their detection with an ambulatory monitoring system.

The benefit for patients is to improve the diagnosis of their diseases by better characterizing their seizures.

lead_sponsor: University Hospital, Grenoble

location_facility: Grenoble University Hospital Epilepsy Monitoring Unit

intervention_type: Device


title: Study of the Efficacy of Skeletal Anchorage (MINISCREW) Compared to Dental Anchorage During Orthodontic Treatment

acronym: Minivis

summary: The main objective of the investigators' study is to assess the efficacy of a course of treatment using skeletal anchorage (MINISCREW) as compared with treatment involving dental anchorage (reference) during dentofacial orthopedic treatment.

study_start_date_type: Actual

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

lead_sponsor: Assistance Publique - Hôpitaux de Paris

lead_sponsor_type: academique

status_simplified: Completed


title: Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome.

acronym: DGVSB

summary: To estimate, in a longitudinal and not invasive way, in patients with SGB at respiratory risk, the function of respiratory muscles and that of the upper airways muscles by investigating the force of the tongue, the gulp, and the breath during the sleep to be able to detect bulbar impairment and establish correlations enter the various parameters to estimate better the interactions between the dysfunction of the respiratory muscles and that upper airways muscles and so determine the risk acute respiratory failure.

study_type: Observational

time_perspective: Prospective


type: Registry Identifier

title: Consideration of the Merits of Continuous Paravertebral Block in the Management of Renal and/or Adrenal Surgery by Laparotomy in Adults

acronym: BPV

summary:
The paravertebral block is an alternative in the analgesia epidural the major interest of which lives in the catheterisation of the paravertébral space allowing to assure/insure an one-sided continuous analgesia.

The main objective of the study is to bring to light the superiority of the continuous paravertébral block, as a supplement to analgesia, in the care of the renal and\or adrenal surgery by laparotomy at the adult in terms of consumption of morphine, with regard to the classic analgesia classic.

The main assessment criterion is the consumption of morphine within first 24 postoperative hours at the patients benefiting from a paravertébral continuous block besides the classic systematic analgesia.

status: Terminated

primary_purpose: Supportive Care

lead_sponsor: University Hospital, Brest

intervention_type: Procedure

status_simplified: Unknown


title: Characterization and Analysis of Long-term Evolution of Renal and Extra-renal Damages in the Course of Nephronophthisis

acronym: NEPHAER

summary: to describe evolution of Nephronophthisis

primary_purpose: Diagnostic

intervention_type: Genetic


type: Other Identifier

title: Assessment of Dynamic Humeral Centering in Impingement Syndrome: a Randomized Clinical Trial

acronym: ADHCIS

summary: The purpose of this study is to determine wether dynamic humeral centering is effective in patients with impingement syndrome of the shoulder

ReferenceType: derived

ReferenceCitation: Beaudreuil J, Ostertag A, Lasbleiz S, Vicaut E, Yelnik A, Bardin T, Orcel P. Efficacy of dynamic humeral centering according to Neer test results: a stratified analysis of a randomized-controlled trial. Int J Rehabil Res. 2015 Mar;38(1):81-3. doi: 10.1097/MRR.0000000000000079.

family: Beaudreuil

full_name: Johann Beaudreuil

given: Johann

sequence: first

family: Ostertag

full_name: Agnès Ostertag

given: Agnès

sequence: additional

family: Lasbleiz

full_name: Sandra Lasbleiz

given: Sandra

family: Vicaut

full_name: Eric Vicaut

given: Eric

family: Yelnik

full_name: Alain Yelnik

given: Alain

family: Bardin

full_name: Thomas Bardin

given: Thomas

family: Orcel

full_name: Philippe Orcel

given: Philippe

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: International Journal of Rehabilitation Research

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

ReferenceCitation: Beaudreuil J, Lasbleiz S, Richette P, Seguin G, Rastel C, Aout M, Vicaut E, Cohen-Solal M, Lioté F, de Vernejoul MC, Bardin T, Orcel P. Assessment of dynamic humeral centering in shoulder pain with impingement syndrome: a randomised clinical trial. Ann Rheum Dis. 2011 Sep;70(9):1613-8. doi: 10.1136/ard.2010.147694. Epub 2011 May 29.

full_name: J. Beaudreuil

given: J.

full_name: S. Lasbleiz

given: S.

family: Richette

full_name: P. Richette

given: P.

family: Seguin

full_name: G. Seguin

given: G.

family: Rastel

full_name: C. Rastel

given: C.

family: Aout

full_name: M. Aout

given: M.

full_name: E. Vicaut

given: E.

family: Cohen-Solal

full_name: M. Cohen-Solal

family: Liote

full_name: F. Liote

given: F.

family: de Vernejoul

full_name: M.-C. de Vernejoul

full_name: T. Bardin

given: T.

full_name: P. Orcel

journal_name: Annals of the Rheumatic Diseases

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

location_facility: Department of Rheumatology, Lariboisière Hospital


title: Effects of Different Insulin Regimens on Artery Compliance, Endothelium Function and Autonomic Cardiac Function in Patients With Poorly Controlled Type 2 Diabetes: a Pilot Study

acronym: INSUVASC

summary: Vago-sympathetic activity, arterial stiffness and endothelial function are integrators of cardiovascular risk. The aim of this pilot study is, in type 2 diabetic patients now requiring insulin, to compare the effects of improving glycemic control on these parameters with 3 different insulin regimens which will act especially at fasting or in post-prandial periods or both. Non invasive explorations will be performed before randomization and after 4 to 5 weeks of insulin therapy, at fasting and each hour after a standardized breakfast.

ReferenceType: background

ReferenceCitation: Nitenberg A, Cosson E, Pham I. Postprandial endothelial dysfunction: role of glucose, lipids and insulin. Diabetes Metab. 2006 Sep;32 Spec No2:2S28-33. Review.

ReferenceCitation: Albertini JP, Valensi P, Lormeau B, Aurousseau MH, Ferrière F, Attali JR, Gattegno L. Elevated concentrations of soluble E-selectin and vascular cell adhesion molecule-1 in NIDDM. Effect of intensive insulin treatment. Diabetes Care. 1998 Jun;21(6):1008-13.

ReferenceCitation: Valensi P, Cosson E. Hemodynamic changes in postprandial state. Diabetes Metab. 2006 Sep;32 Spec No2:2S37-41. Review.

ReferenceCitation: Valensi P, Thi BN, Lormeau B, Pariès J, Attali JR. Cardiac autonomic function in obese patients. Int J Obes Relat Metab Disord. 1995 Feb;19(2):113-8.

ReferenceCitation: Dabiré H, Brahimi M, Hadj-Brahim F, Le Clésiau H, Attali JR, Valensi P. [Role of vagosympathetic balance in obesity-induced hypertension]. Arch Mal Coeur Vaiss. 2004 Jul-Aug;97(7-8):749-52. French.

ReferenceCitation: Valensi P, Pariès J, Attali JR; French Group for Research and Study of Diabetic Neuropathy. Cardiac autonomic neuropathy in diabetic patients: influence of diabetes duration, obesity, and microangiopathic complications--the French multicenter study. Metabolism. 2003 Jul;52(7):815-20.

ReferenceCitation: Valensi P, Pariès J, Lormeau B, Attia S, Attali JR. Influence of nutrients on cardiac autonomic function in nondiabetic overweight subjects. Metabolism. 2005 Oct;54(10):1290-6.

ReferenceCitation: Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, Da Ros R, Motz E. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation. 2002 Sep 3;106(10):1211-8.

ReferenceCitation: Valensi P, Smagghue O, Pariès J, Velayoudon P, Nguyen TN, Attali JR. Peripheral vasoconstrictor responses to sympathetic activation in diabetic patients: relationship with rheological disorders. Metabolism. 1997 Mar;46(3):235-41.

ReferenceCitation: Valensi P, Smagghue O, Pariès J, Velayoudon P, Lormeau B, Attali JR. Impairment of skin vasoconstrictive response to sympathetic activation in obese patients: influence of rheological disorders. Metabolism. 2000 May;49(5):600-6.

ReferenceCitation: Sibony-Prat J, Paries J, Chabert M, Attali JR, Valensi P. [Alteration of cardiovascular vagosympathetic control evaluated by spectral analysis of variations of heart rate and blood pressure in obesity]. Arch Mal Coeur Vaiss. 1997 Aug;90(8):1155-8. French.

ReferenceCitation: Fysekidis M, Cosson E, Takbou K, Sutton A, Charnaux N, Banu I, Vicaut E, Valensi P. Effects of insulin analogs as an add-on to metformin on cutaneous microcirculation in type 2 diabetic patients. Microvasc Res. 2018 Mar;116:6-14. doi: 10.1016/j.mvr.2017.09.005. Epub 2017 Sep 24.

family: Fysekidis

full_name: Marinos Fysekidis

given: Marinos

family: Cosson

full_name: Emmanuel Cosson

given: Emmanuel

family: Takbou

full_name: Karim Takbou

given: Karim

family: Sutton

full_name: Angela Sutton

given: Angela

family: Charnaux

full_name: Nathalie Charnaux

given: Nathalie

family: Banu

full_name: Isabella Banu

given: Isabella

family: Valensi

full_name: Paul Valensi

given: Paul

journal_name: Microvascular Research

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

location_facility: Jean Verdier hospital, Department of Endocrinology-Diabetology-Nutrition

intervention_type: Drug


title: Intra-arterial Measurement of pO2 in Walking Induced Transient Hack ("WITH") Profiles

acronym: Initial-VHS

summary: Confirm with invasive measurement the presence of a Walking-Induced Transient Hack (WITH) profile

lead_sponsor: University Hospital, Angers

intervention_type: Other


title: Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) at High Frequency With Neuronavigation in the Treatment of Auditory Hallucinations : A Randomized Multicentric Controlled Study

acronym: TMS-Hz

summary:
Background:

Repetitive transcranial magnetic stimulation (rTMS) is a recent therapeutic which has demonstrated its efficacy in the treatment of auditory hallucinations in patients with schizophrenic disorders. Up to now, the target of stimulation has been over the left temporoparietal region (based on the international 10-20 EEG system) and rTMS has been delivered at low frequency (1 Hz).

High frequency (20 Hz) might allow shortening the duration of treatment and so could be more convenient for the patient (2 days at high frequency instead of 15 days at low frequency).

Besides high frequency, an accurate target taking into account the inter-subjects anatomical variability might increase the efficacy. Based on a great overlap of language and auditory hallucinations networks, the investigators hypothesized that targeting the stimulation on the highest cluster of activation induced by a language task could be an easier and relevant method to determine the target. The investigators suggest that the best area is located at the posterior part of the left superior temporal sulcus (STS). Indeed, this area is considered as an " epicenter " of language, i.e., involved both in understanding and production of language and in the auditory hallucination network. Therefore, the investigators conducted an open pilot study in order to test the interest of rTMS at high frequency (20 Hz) associated with anatomical and functional magnetic resonance imaging (MRI) and neuronavigation in 11 schizophrenic patients with hallucinations. The investigators showed a significant reduction of auditory hallucinations; Seven out of 11 patients (63.8%) were considered as responders at day 12 with a decrease of more than 30% of the score of Hoffman's scale (Auditory Hallucinations Rating Scale) ; 2 patients presented a drastic improvement with no hallucinations after 12 days of rTMS. The investigators also showed the target based on anatomical and functional MRI was located at the intersection of the left STS and the coronal slice across the vertical line of sylvius sulcus.

The aim of this multicentric double-blind study (randomized and placebo sham) is to demonstrate the efficacy of rTMS at high frequency with neuronavigation in the treatment of auditory hallucinations in patients with schizophrenia and schizo-affective disorders (DSMIV-R).

Methods:

72 subjects will be included after written consent. After randomization, the subject will receive in a double blind either active treatment or placebo (sham coil) treatment.

rTMS : 4 sessions of 13 minutes, with 2 sessions a day, at 20Hz frequency and at an intensity of 80% of rest motor threshold will be delivered. These parameters allow the investigators to be under the risk of epilepsia, the only one severe side effect. Another mild side effect is headache easily treated by antalgic drugs. The target will be established with anatomical MRI eventually associated with functional MRI before treatment.

The efficacy of treatment will be evaluated over 4 weeks (D0, D1, D2, D7, D14, D21 and D30). The primary assessment is the percentage of patients who present a decrease of more than 30% of the frequency item of Auditory Hallucinations Rating Scale (AHRS) between D1 and D30 at 2 evaluations spaced of 1 week (Responder patients). The secondary assessments are : 1- Relative decrease of frequency item of AHRS between D1 and D14 ; 2- Evolution of total score of AHRS at D1, D2, D7, D14, D21 and D30 ; 3- Variation of scores of CGI, SUMD, IS, positive, negative, general and total PANSS scores between D0 and D14 and D30 ; 4- Scores at secondary side effects (adapted UKU) at D2 and D7; 5- Distances between the present target and the classical target based on 10-20 EEG system (T3P3) and/or the target established with functional MRI (cluster of activations induced by a listening comprehension task).

lead_sponsor: University Hospital, Caen


title: Respiratory Improvement of Faciocraniosynostosis by Craniofacial Osteodistraction

acronym: CRANIORESP

summary:
Context. Faciocraniosynostoses present with an insufficient growth of the craniofacial skeleton due to premature fusion of skull and facial sutures. There are prenatal conditions with functional (risk of raised intracranial pressure) and morphological consequences (exorbitism, and impairment of upper respiratory airways), the severity of which justifies an early surgical treatment based on craniofacial osteotomies and osteodistraction techniques.

Distraction techniques were started in our unit eleven years ago, and never ceased to be modified: Recent improvements allowed better correction of exorbitism and therefore reduction of visual risks. But the improvements of the respiratory function remain insufficient. The initial evaluations of the respiratory functions were based on blood oxygenation monitoring, and showed real improvement. But we have routinely screened our patients with complete polysomnography examinations for the past year, and this has always revealed the existence of severe sleep apnea syndromes that we fail to correct completely, although there were slightly improved.

The aim of this PHRC protocol is :

the qualitative and quantitative improvement of the respiratory status with a reinforced task force group including the specialists in genuine multidisciplinary approach.
A modification of the surgical technique including modifications of the existing distraction devices, an increased number of implanted devices, and maybe a change in the surgical strategy.

primary_purpose: Other

ReferenceType: result

ReferenceCitation: Khonsari RH, Haber S, Paternoster G, Fauroux B, Morisseau-Durand MP, Cormier-Daire V, Legeai-Mallet L, James S, Hennocq Q, Arnaud E. The influence of fronto-facial monobloc advancement on obstructive sleep apnea: An assessment of 109 syndromic craniosynostoses cases. J Craniomaxillofac Surg. 2020 Jun;48(6):536-547. doi: 10.1016/j.jcms.2020.04.001. Epub 2020 Apr 13.

family: Khonsari

full_name: Roman Hossein Khonsari

given: Roman Hossein

family: Haber

full_name: Samer Haber

given: Samer

family: Paternoster

full_name: Giovanna Paternoster

given: Giovanna

family: Fauroux

full_name: Brigitte Fauroux

given: Brigitte

family: Morisseau-Durand

full_name: Marie-Paule Morisseau-Durand

given: Marie-Paule

family: Cormier-Daire

full_name: Valérie Cormier-Daire

given: Valérie

family: Legeai-Mallet

full_name: Laurence Legeai-Mallet

given: Laurence

family: James

full_name: Syril James

given: Syril

family: Hennocq

full_name: Quentin Hennocq

given: Quentin

family: Arnaud

full_name: Eric Arnaud

given: Eric

journal_name: Journal of Cranio-Maxillofacial Surgery

oa_host_type: publisher

evidence: open (author manuscript)

host_type: publisher

license_normalized: no license

version: acceptedVersion


title: Lipid Profile of Tenon's Capsule in Glaucoma Patients

summary: The purpose of this study is to provide data on the lipid profile of the Tenon's capsule in Human glaucomatous eyes and to establish possible relationships with the short term outcome of filtration surgery.

lead_sponsor: Centre Hospitalier Universitaire Dijon


title: Maintenance of Anticoagulant and Antiplatelet Agents for Patients Undergoing Vitreoretinal Surgery

summary: Purpose: To establish the prevalence of anticoagulant, aspirin, and clopidogrel use in patients undergoing vitreoretinal surgery, and to compare the outcome of peribulbar anesthesia between users and non-users.

time_perspective: Retrospective


title: Evaluation of Accuvein for Blood Sampling and for Intravenous Catheter Placement in Adult Patients

summary: The objective of this study is to evaluate the effectiveness of Accuvein to facilitate venous blood sampling and placement of peripheral intravenous catheters in adults. This clinical protocol is designed to determine whether using Accuvein increases the ease and efficiency of venous cannulation (as perceived by the operator), decreases the time to effective cannulation, decreases the number of sticks, and decreases the patient's perception of the pain.

design_allocation: Non-Randomized

ReferenceCitation: Aulagnier J, Hoc C, Mathieu E, Dreyfus JF, Fischler M, Le Guen M. Efficacy of AccuVein to facilitate peripheral intravenous placement in adults presenting to an emergency department: a randomized clinical trial. Acad Emerg Med. 2014 Aug;21(8):858-63. doi: 10.1111/acem.12437.

name: The Emergency Department; Versaille France

family: Aulagnier

full_name: Jérôme Aulagnier

given: Jérôme

family: Hoc

full_name: Cécile Hoc

given: Cécile

family: Mathieu

full_name: Emmanuel Mathieu

name: The Department of Clinical Research and Innovation; Versaille France

family: Dreyfus

full_name: Jean François Dreyfus

given: Jean François

name: The Department of Anesthesiology; Hôpital Foch; Suresnes Versaille France

name: The University Versailles Saint-Quentin en Yvelines; Versaille France

family: Fischler

full_name: Marc Fischler

given: Marc

family: Le Guen

full_name: Morgan Le Guen

given: Morgan

journal_name: Academic Emergency Medicine

evidence: open (via free pdf)

version: publishedVersion

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

title: Efficacy of AccuVein to Facilitate Peripheral Intravenous Placement in Adults Presenting to an Emergency Department: A Randomized Clinical Trial

lead_sponsor: Hopital Foch


title: Effect of Music Therapy on Chronic Pain in Hospitalized Patients in a Pain Center

summary: The aim of study is to assess the effects of this new music therapy technique on pain treatment, anxiety and depression and on medicinal consumption.

ReferenceCitation: Roy M, Peretz I, Rainville P. Emotional valence contributes to music-induced analgesia. Pain. 2008 Jan;134(1-2):140-7. Epub 2007 May 25.

ReferenceCitation: Cepeda MS, Carr DB, Lau J, Alvarez H. Music for pain relief. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD004843. Review. Update in: Cochrane Database Syst Rev. 2013;10:CD004843.

ReferenceCitation: Guétin S, Portet F, Picot MC, Pommié C, Messaoudi M, Djabelkir L, Olsen AL, Cano MM, Lecourt E, Touchon J. Effect of music therapy on anxiety and depression in patients with Alzheimer's type dementia: randomised, controlled study. Dement Geriatr Cogn Disord. 2009;28(1):36-46. doi: 10.1159/000229024. Epub 2009 Jul 23.

family: Guétin

full_name: S. Guétin

given: S.

family: Portet

full_name: F. Portet

given: F.

family: Picot

full_name: M.C. Picot

family: Pommié

full_name: C. Pommié

given: C.

family: Messaoudi

full_name: M. Messaoudi

given: M.

family: Djabelkir

full_name: L. Djabelkir

given: L.

family: Olsen

full_name: A.L. Olsen

family: Cano

full_name: M.M. Cano

family: Lecourt

full_name: E. Lecourt

given: E.

family: Touchon

full_name: J. Touchon

given: J.

journal_name: Dementia and Geriatric Cognitive Disorders

publisher: S. Karger AG

publisher_dissemination: S. Karger AG

publisher_group: S. Karger AG

publisher_normalized: S. Karger AG

title: Effect of Music Therapy on Anxiety and Depression in Patients with Alzheimer’s Type Dementia: Randomised, Controlled Study

lead_sponsor: Association de Musicothérapie Applications et Recherches Cliniques

location_facility: CHRU Saint Eloi, Centre d'Evaluation et du Traitement de la Douleur

lead_sponsor_type: industriel


title: Virologic and Immunologic Evaluation of the Deep Viral Reservoirs in HIV-1 Infected Patients With Long Term Viral Suppression

acronym: MUCOVIR

summary: Prospective study in HIV-1 infected patients with a plasma viral load below the limit of detection and stable for at least 5 years.

ReferenceCitation: Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G; DECAMUNE and ORVACS Study Groups. Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients. J Acquir Immune Defic Syndr. 2013 Mar 1;62(3):255-9. doi: 10.1097/QAI.0b013e318282537f.

family: Descours

full_name: Benjamin Descours

given: Benjamin

family: Lambert-Niclot

full_name: Sidonie Lambert-Niclot

given: Sidonie

family: Mory

full_name: Benoît Mory

given: Benoît

family: Samri

full_name: Assia Samri

given: Assia

family: Charlotte

full_name: Fréderic Charlotte

given: Fréderic

family: Peytavin

full_name: Gilles Peytavin

given: Gilles

family: Tubiana

full_name: Roland Tubiana

given: Roland

family: Papagno

full_name: Laura Papagno

given: Laura

family: Bacchus

full_name: Charline Bacchus

given: Charline

family: Lecardonnel

full_name: François Lecardonnel

given: François

family: Katlama

full_name: Christine Katlama

given: Christine

family: Autran

full_name: Brigitte Autran

given: Brigitte

family: Marcelin

full_name: Anne-Geneviève Marcelin

given: Anne-Geneviève

family: Valantin

full_name: Marc-Antoine Valantin

given: Marc-Antoine

family: Carcelain

full_name: Guislaine Carcelain

given: Guislaine

journal_name: JAIDS Journal of Acquired Immune Deficiency Syndromes

title: Direct Quantification of Cell-Associated HIV DNA in Isolated Rectal and Blood Memory CD4 T Cells Revealed Their Similar and Low Infection Levels in Long-Term Treated HIV-Infected Patients

lead_sponsor: Objectif Recherche Vaccins SIDA


title: Impact of Objective Sleep Duration on Blood Glucose Control in Type 1 Diabetes Adult Patients

summary:
The objective of this study is to assess the impact of objective sleep duration on blood glucose control in type 1 diabetes adult patients.

This study will also evaluate the impact of objective sleep duration on blood pressure over a 24-hour period and the impact of objective sleep duration on quality of life.

Last, it will investigate the influence of objective physical activity duration on blood glucose control, blood pressure and quality of life.

ReferenceCitation: Borel AL, Pépin JL, Nasse L, Baguet JP, Netter S, Benhamou PY. Short sleep duration measured by wrist actimetry is associated with deteriorated glycemic control in type 1 diabetes. Diabetes Care. 2013 Oct;36(10):2902-8. doi: 10.2337/dc12-2038. Epub 2013 May 28.

family: Borel

full_name: A.-L. Borel

family: Pepin

full_name: J.-L. Pepin

family: Nasse

full_name: L. Nasse

given: L.

family: Baguet

full_name: J.-P. Baguet

family: Netter

full_name: S. Netter

given: S.

family: Benhamou

full_name: P.-Y. Benhamou

journal_name: Diabetes Care

oa_colors: green other

oa_host_type: publisher;repository

evidence: open (via page says license)

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

publisher: American Diabetes Association

publisher_dissemination: American Diabetes Association

publisher_group: American Diabetes Association

publisher_normalized: American Diabetes Association

title: Short Sleep Duration Measured by Wrist Actimetry Is Associated With Deteriorated Glycemic Control in Type 1 Diabetes

location_facility: Service de Diabétologie du Pr Halimi, CHU


title: Respiratory Mechanical Effects of Sevoflurane Administered With the Anesthetic Conserving Device in Pressure Support Ventilation

summary: Sevoflurane inhalational anesthetic has got pulmonary effects such as bronchodilatation. These effects could be of interest in intensive care patients ventilated in pressure support ventilation mode. The purpose of this study is to evaluate mechanical respiratory effects of sevoflurane administered through a new specific heat and moister exchanger called the Anesthetic Conserving Device (AnaConDa®) in pressure support ventilation in intensive care patients. In fact, dead space and resistance generated by the device could cancel and even deteriorate the potential positive effects of sevoflurane on ventilation.

ReferenceCitation: Constantin JM, Futier E, Perbet S, Roszyk L, Lautrette A, Gillart T, Guerin R, Jabaudon M, Souweine B, Bazin JE, Sapin V. Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: a prospective study. J Crit Care. 2010 Mar;25(1):176.e1-6. doi: 10.1016/j.jcrc.2009.05.010. Epub 2009 Sep 24.

lead_sponsor: University Hospital, Clermont-Ferrand


title: Bacterial Colonization After Tunneling in Femoral Perineural Catheters

acronym: Tunnelized KT

summary:
Background: Bacterial colonization of peripheral nerve catheters is frequent, although infection is relatively rare. With central venous catheters, the tunneling of catheter into the subcutaneous tissue significantly decreases catheter colonization and catheter-related sepsis.

Purpose: The aim of this study is to evaluate the incidence of bacterial colonization in adult patients with femoral tunnelized perineural nerve catheters.

Methods: A total of 338 patients with femoral catheter will be included in the study. The patients will be randomized to be included in the control group (without tunnelling) or in the group with catheter tunneled 2-3 cm subcutaneously. After removal, catheter will be analyzed for colonization (primary outcome). Quantitative culture will be used as described by Brun-Buisson for intravascular catheters. The site of insertion will be monitored daily for any signs of infection (secondary outcome).

Perspective: To show the incidence of femoral perineural catheter colonization is low with subcutaneous tunneling

primary_purpose: Prevention

lead_sponsor: University Hospital, Rouen


title: Assessment of the Nociception During Lumbar Surgery

summary: The aim of the study is to assess the accuracy of a new paradigm in measuring the level of nociception during lumbar surgery. The paradigm is based the measurement of the baroreflex in response to noxious stimuli in anesthetized patients.

primary_purpose: Basic Science


title: AML 2001: a Phase III Prospective Randomized Study Comparing One or Two High Dose Chemotherapy Regimen Followed by Autologous Stem Cell Transplantation (ASCT) as Consolidation Strategy for Adults Aged 15 to 60 With Acute Myeloid Leukemia (AML) in First Complete Remission (CR).rémission complète d'Une Leucémie Aiguë Myéloblastique

summary:
First randomization:

After inclusion Use of Daunorubicin (arm D) or Idarubicin (arm I) as anthracyclin during all courses of chemotherapy (induction, consolidation courses before ASCT)

Second randomization:

After achieving 1st CR: all patients received non intensive consolidation course Familial HLA typing required for all patients

Patients with HLA-identical sibling:

Patients with very good prognostic factors (CBF leukemias, WBC < 30 giga/l at diagnosis, 1st CR after one induction course) = arm C: no allogeneic stem cell transplantation in 1st CR; received 2 more courses of intensive consolidation chemotherapy All others patients received an allogeneic transplant For patients aged less than 51 = arm M: upfront myeloablative conditioning regimen For patients aged over 51 and less than 61= arm m: intensive chemotherapy consolidation course.

ReferenceCitation: Bertoli S, Bories P, Béné MC, Daliphard S, Lioure B, Pigneux A, Vey N, Delaunay J, Leymarie V, Luquet I, Blanchet O, Cornillet-Lefebvre P, Hunault M, Bouscary D, Fegueux N, Guardiola P, Dreyfus F, Harousseau JL, Cahn JY, Ifrah N, Récher C; Groupe Ouest-Est d'Etude des Leucémies Aiguës et Autres Maladies du Sang (GOELAMS). Prognostic impact of day 15 blast clearance in risk-adapted remission induction chemotherapy for younger patients with acute myeloid leukemia: long-term results of the multicenter prospective LAM-2001 trial by the GOELAMS study group. Haematologica. 2014 Jan;99(1):46-53. doi: 10.3324/haematol.2013.091819. Epub 2013 Aug 23.

family: Bertoli

full_name: S. Bertoli

family: Bories

full_name: P. Bories

given: P.

family: Bene

full_name: M. C. Bene

given: M. C.

family: Daliphard

full_name: S. Daliphard

family: Lioure

full_name: B. Lioure

given: B.

family: Pigneux

full_name: A. Pigneux

given: A.

family: Vey

full_name: N. Vey

given: N.

family: Delaunay

full_name: J. Delaunay

given: J.

family: Leymarie

full_name: V. Leymarie

given: V.

family: Luquet

full_name: I. Luquet

given: I.

family: Blanchet

full_name: O. Blanchet

given: O.

family: Cornillet-Lefebvre

full_name: P. Cornillet-Lefebvre

family: Hunault

full_name: M. Hunault

given: M.

family: Bouscary

full_name: D. Bouscary

given: D.

family: Fegueux

full_name: N. Fegueux

family: Guardiola

full_name: P. Guardiola

family: Dreyfus

full_name: F. Dreyfus

given: F.

family: Harousseau

full_name: J. L. Harousseau

given: J. L.

family: Cahn

full_name: J. Y. Cahn

given: J. Y.

family: Ifrah

full_name: N. Ifrah

family: Recher

full_name: C. Recher

given: C.

name: on behalf of the Groupe Ouest-Est d'Etude des Leucemies Aigues et Autres Maladies du Sang (GOELAMS)

currency_apc_doaj: EUR

journal_name: Haematologica

oa_colors: green gold

evidence: oa journal (via doaj)

publisher: Ferrata Storti Foundation (Haematologica)

ReferenceCitation: Guièze R, Cornillet-Lefebvre P, Lioure B, Blanchet O, Pigneux A, Recher C, Bonmati C, Fegueux N, Bulabois CE, Bouscary D, Vey N, Delain M, Turlure P, Himberlin C, Harousseau JL, Dreyfus F, Béné MC, Ifrah N, Chevallier P; GOELAMS. Role of autologous hematopoietic stem cell transplantation according to the NPM1/FLT3-ITD molecular status for cytogenetically normal AML patients: a GOELAMS study. Am J Hematol. 2012 Dec;87(12):1052-6. doi: 10.1002/ajh.23311. Epub 2012 Aug 22.

title: Role of autologous hematopoietic stem cell transplantation according to the NPM1/FLT3-ITD molecular status for cytogenetically normal AML patients: A GOELAMS study

ReferenceCitation: Lioure B, Béné MC, Pigneux A, Huynh A, Chevallier P, Fegueux N, Blaise D, Witz B, Delain M, Cornillon J, Luquet I, Blanchet O, Cornillet-Lefebvre P, Carré M, Hunault M, Larosa F, Lamy T, Randriamalala E, Ojeda-Uribe M, Berthou C, Fornecker L, Harousseau JL, Bouscary D, Ifrah N, Cahn JY; GOELAMS. Early matched sibling hematopoietic cell transplantation for adult AML in first remission using an age-adapted strategy: long-term results of a prospective GOELAMS study. Blood. 2012 Mar 22;119(12):2943-8. doi: 10.1182/blood-2011-05-352989. Epub 2012 Feb 9.

name: Department of Hematology, CHU, Strasbourg, France;

name: Department of Immunology, CHU and Nancy University, Nancy, France;

name: Department of Hematology, CHU, Bordeaux, France;

name: Department of Hematology, CHU, Toulouse, France;

name: Department of Hematology, CHU, Nantes, France;

name: Department of Hematology, CHU, Montpellier, France;

name: Department of Hematology, Institut Paoli-Calmette, Marseille, France;

name: Department of Hematology, CHU, Nancy, France;

name: Department of Hematology, CHU, Tours, France;

name: Department of Hematology, Institut de Cancérologie de la Loire, Saint-Etienne, France;

name: Department of Hematology/Biology, CHU, Reims, France;

name: Department of Hematology/Biology, CHU, Angers, France;

name: Department of Hematology, CHU, Grenoble, France;

name: Department of Hematology, CHU, Angers, France;

name: Department of Hematology, CHU, Besançon, France;

name: Department of Hematology, CHU, Rennes, France;

name: Oncologie et Thérapie Cellulaire, CHU, Poitiers, France;

name: Department of Hematology, CH, Mulhouse, France;

name: Department of Hematology, CHU, Brest, France;

name: Department of Hematology, Centre René Gauducheau, Nantes, France; and

name: Department of Hematology, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, Paris, France


title: Laparoscopic Roux-en-Y Gastric Bypass Outcomes With Systematic Gastric Stapling Line Reinforcement With Seamguard Biomaterial

summary:
Study objectives :

Primary endpoint is to a assess the change in blood loss (originating from stapling the stomach) with the use of Seamguard reinforcement Secondary endpoint is to evaluate the difference in leak rate

Methods :

Prospective. Randomized study. Published data does not allow for clear determination of the number of patients required for the study. Based on our own experience. The investigators estimate that the average postoperative blood loss is 200ml with a standard deviation of 100ml over 3 days. Based on this assumption. A total number of patients (control + Seamguard groups) of 60 is required if the expected reduction of the mean drainage volume is 100ml and 82 patients for an expected drainage volume reduction of 85ml.

All patients candidates to a laparoscopic gastric bypass will be enrolled in the study Under the conditions this is a primary bariatric procedure (no revision allowed)., no history of hiatal surgery such as anti-reflux nor significant upper abdominal surgery. The only associated surgical procedure allowed is the cholecystectomy.

Patients' inclusion :

Will be done immediately before surgical procedure following acceptance of a written consent.

Bleeding from liver or slpeen injury will lead to patient's exclusion.

Methods :

Surgical procedures are identical for the 2 surgeons of the study (GB and PT) with 30-50ml gastric pouch. Linear. side to side. Antegastric and antecolic gastrojejunal anstomosis . Use of Echelon 60 linear stapler with GOLD cartridges on stomach. Blue to perform the gastrojejunal anastomosis and white on Small bowel. Peroperativeblood loss and need to apply clips or stitches on the gastric staple line are recorded. Operation time and patient information (BMI. Comorbidities) are recorded as well any noticeable or unexpected event.

Postoperative blood loss is assessed by at least 1 abdominal closed circuit suction drain left for a minimum of 3 days (removal on postop day 3 at the earliest).

In addition hemoglobin and red cell count is performed on postop day 1 and 2. Absence of leakage is confirmed by methylene blue test perop as well as on postop day 1 before resuming fluids and on postop day 2 by a gastrograffin swallow. Drinks and food are resumed according to the standard practice between postop day 1 and postop day 2.

Duration of the hospital stay and postoperative course will be documented. Early follow up is clinically done at 1 month postop without any specific radiological or biological examination.

Data collection Will be done on a form during and after the procedure

BLOOD LOSS : peroperative volume as well as daily drainage output (postop day 1. 2 and 3) as well as the sum of the 3 postop days.

Hemoglobin change is recorded on day 1 and 2. Need to leave drain(s) for more than 3 days is recorded.

Study completion :

Estimated time to complete the study based on the current experience is between 5 and 7 months. Sudy is closed 1 month after the last inclusion.

enrollment_type: Anticipated

lead_sponsor: Clinique de l'Anjou


title: Study of Efficacy of OXN PR, Compared to Oxy PR, for Reduction of Intensity of Opioid-induced Constipation Symptoms in Pts Treated for Cancer or Non-cancer Pain: A Randomised, Double-blind, Controlled, Multicentre Study

summary: The primary objective of this trial is to study the efficacy of oxycodone/naloxone prolonged release tablets (OXN PR), compared to oxycodone prolonged release tablets (Oxy PR), for the reduction of the intensity of opioid-induced constipation symptoms in patients treated for cancer or non-cancer pain.

lead_sponsor: Mundipharma SAS


title: Phase III Study of Hydrocortisone in Patients With Severe H1N1 Related Pneumonia

acronym: CORTIFLU

summary: The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is rapidly progressing worldwide and a substantial number of patients get severe H1N1 related pneumonia that requires mechanical ventilation and admission to the intensive care unit. The acute respiratory distress syndrome is associated with a substantial mortality and morbidity partly as a consequence of uncontrolled lung and systemic inflammation. many physicians are trying to counteract this pro-inflammatory storm by the use of corticosteroids albeit these drugs may cause super infection or metabolic disorders. Thus, there is a need for a randomized double blind, placebo controlled trial to define the benefit to risk ratio of corticosteroids in this patient.

ReferenceCitation: Annane D, Antona M, Lehmann B, Kedzia C, Chevret S; CORTIFLU Investigators; CRICs; AZUREA; REVA/SRLF networks. Designing and conducting a randomized trial for pandemic critical illness: the 2009 H1N1 influenza pandemic. Intensive Care Med. 2012 Jan;38(1):29-39. doi: 10.1007/s00134-011-2409-8. Epub 2011 Nov 26.

family: Annane

full_name: Djillali Annane

given: Djillali

name: the CORTIFLU Investigators and the CRICs, AZUREA, and REVA/SRLF networks

family: Antona

full_name: Marion Antona

given: Marion

family: Lehmann

full_name: Blandine Lehmann

given: Blandine

family: Kedzia

full_name: Cecile Kedzia

given: Cecile

family: Chevret

full_name: Sylvie Chevret

given: Sylvie

journal_name: Intensive Care Medicine

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer

publisher_group: Springer

publisher_normalized: Springer

lead_sponsor: University of Versailles


title: Recruitment Maneuver Increases Oxygenation After Intubation in Hypoxemic ICU Patients: a Randomized Controlled Study

summary: The purpose of this study is to evaluate the safety and efficacy of a recruitment maneuver immediately after intubation in hypoxemic patients.

ReferenceCitation: Constantin JM, Futier E, Cherprenet AL, Chanques G, Guerin R, Cayot-Constantin S, Jabaudon M, Perbet S, Chartier C, Jung B, Guelon D, Jaber S, Bazin JE. A recruitment maneuver increases oxygenation after intubation of hypoxemic intensive care unit patients: a randomized controlled study. Crit Care. 2010;14(2):R76. doi: 10.1186/cc8989. Epub 2010 Apr 28.

family: Constantin

full_name: Jean-Michel Constantin

given: Jean-Michel

family: Futier

full_name: Emmanuel Futier

given: Emmanuel

family: Cherprenet

full_name: Anne-Laure Cherprenet

given: Anne-Laure

family: Chanques

full_name: Gerald Chanques

given: Gerald

family: Guerin

full_name: Renaud Guerin

given: Renaud

family: Cayot-Constantin

full_name: Sophie Cayot-Constantin

given: Sophie

family: Jabaudon

full_name: Mathieu Jabaudon

given: Mathieu

family: Perbet

full_name: Sebastien Perbet

given: Sebastien

family: Chartier

full_name: Christian Chartier

given: Christian

family: Jung

full_name: Boris Jung

given: Boris

family: Guelon

full_name: Dominique Guelon

given: Dominique

family: Jaber

full_name: Samir Jaber

given: Samir

family: Bazin

full_name: Jean-Etienne Bazin

given: Jean-Etienne

currency_apc_doaj: GBP

journal_name: Critical Care

license: cc-by

license_normalized: cc-by

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

repository_normalized: HAL

repositories:
HAL
PubMed Central


title: Evaluation de la Mesure du Taux de la Procalcitonine Dans Les Liquides Pleuraux

summary: The purpose of this study is to determine pleural level of procalcitonin in differents situations of pleuritis.

lead_sponsor: Centre Hospitalier Universitaire, Amiens


title: Efficacy and Tolerance of Cyproterone Acetate Versus Medroxyprogesterone Acetate Versus Venlafaxine LP in the Treatment of Hot Flushes Caused by Leuprorelin 11.25 mg in Patients Treated for a Prostate Adenocarcinoma

summary: The purpose of this study is to compare the efficacy of three drugs (cyproterone acetate, medroxyprogesterone acetate and venlafaxine) in the treatment of hot flushes caused by leuprorelin LP 11.25 milligram (mg) in participants suffering from prostate cancer.

ReferenceCitation: Irani J, Salomon L, Oba R, Bouchard P, Mottet N. Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial. Lancet Oncol. 2010 Feb;11(2):147-54. doi: 10.1016/S1470-2045(09)70338-9. Epub 2009 Dec 4.

family: Irani

full_name: Jacques Irani

given: Jacques

family: Salomon

full_name: Laurent Salomon

given: Laurent

family: Oba

full_name: Rostand Oba

given: Rostand

family: Bouchard

full_name: Philippe Bouchard

given: Philippe

family: Mottet

full_name: Nicolas Mottet

given: Nicolas

journal_name: The Lancet Oncology

lead_sponsor: Takeda


title: Caractérisation de Nouveaux Biomarqueurs de l'Arthrite Septique Par Technique SELDI-TOF

acronym: NOUBASST

summary:
Septic arthritis is a frequent, potentially disabling and/or life-threatening disease. To diagnose a septic arthritis is a complex procedure, first because of numerous differential diagnoses (such as crystal arthritis), second because of poor sensitivity of initial gram staining (for example after untimely antibiotic therapy).

This protocol will use SELDI-TOF as a tool to analyse joint fluid of patients with various acute, polymorphonuclear-rich arthritis, as to determine specific and sensitive new biomarkers of a septic origin.

Such biomarkers will allow rapid diagnosis of septic arthritis in the first hours of admission.


title: Multipolar Radiofrequency Ablation for the Treatment of Hepatocellular Carcinoma Using Classical Intranodular Technique Versus Extra Nodular Technique So-called "No Touch" Technique: A Prospective Randomized Trial

acronym: ARMCENVIN

summary: The primary purpose of the trial is to demonstrate that at least a 40% drop of recurrence rate can be achieve in hepatocellular carcinoma patients treated with no touch multipolar radiofrequency ablation technique compared to those treated with usual intranodular multipolar technique.

ReferenceCitation: Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, Zhang YQ, Lin XJ, Lau WY. A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Ann Surg. 2006 Mar;243(3):321-8.

ReferenceCitation: Kotoh K, Enjoji M, Arimura E, Morizono S, Kohjima M, Sakai H, Nakamuta M. Scattered and rapid intrahepatic recurrences after radio frequency ablation for hepatocellular carcinoma. World J Gastroenterol. 2005 Nov 21;11(43):6828-32.

ReferenceCitation: Seror O, N'Kontchou G, Tin-Tin-Htar M, Barrucand C, Ganne N, Coderc E, Trinchet JC, Sellier N, Beaugrand M. Radiofrequency ablation with internally cooled versus perfused electrodes for the treatment of small hepatocellular carcinoma in patients with cirrhosis. J Vasc Interv Radiol. 2008 May;19(5):718-24. doi: 10.1016/j.jvir.2008.01.007. Epub 2008 Mar 17.

ReferenceCitation: Harrison LE, Koneru B, Baramipour P, Fisher A, Barone A, Wilson D, Dela Torre A, Cho KC, Contractor D, Korogodsky M. Locoregional recurrences are frequent after radiofrequency ablation for hepatocellular carcinoma. J Am Coll Surg. 2003 Nov;197(5):759-64.

ReferenceCitation: Mazzaferro V, Battiston C, Perrone S, Pulvirenti A, Regalia E, Romito R, Sarli D, Schiavo M, Garbagnati F, Marchianò A, Spreafico C, Camerini T, Mariani L, Miceli R, Andreola S. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study. Ann Surg. 2004 Nov;240(5):900-9.

ReferenceCitation: Kotoh K, Morizono S, Kohjima M, Enjoji M, Sakai H, Nakamuta M. Evaluation of liver parenchymal pressure and portal endothelium damage during radio frequency ablation in an in vivo porcine model. Liver Int. 2005 Dec;25(6):1217-23.

ReferenceCitation: Kotoh K, Nakamuta M, Morizono S, Kohjima M, Arimura E, Fukushima M, Enjoji M, Sakai H, Nawata H. A multi-step, incremental expansion method for radio frequency ablation: optimization of the procedure to prevent increases in intra-tumor pressure and to reduce the ablation time. Liver Int. 2005 Jun;25(3):542-7.

ReferenceCitation: Nakamuta M, Kohjima M, Morizono S, Yoshimoto T, Miyagi Y, Sakai H, Enjoji M, Kotoh K. Comparison of tissue pressure and ablation time between the LeVeen and cool-tip needle methods. Comp Hepatol. 2006 Dec 21;5:10.

ReferenceCitation: Okusaka T, Okada S, Ueno H, Ikeda M, Shimada K, Yamamoto J, Kosuge T, Yamasaki S, Fukushima N, Sakamoto M. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features. Cancer. 2002 Nov 1;95(9):1931-7.

ReferenceCitation: Pawlik TM, Delman KA, Vauthey JN, Nagorney DM, Ng IO, Ikai I, Yamaoka Y, Belghiti J, Lauwers GY, Poon RT, Abdalla EK. Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl. 2005 Sep;11(9):1086-92.

ReferenceCitation: Shi M, Guo RP, Lin XJ, Zhang YQ, Chen MS, Zhang CQ, Lau WY, Li JQ. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial. Ann Surg. 2007 Jan;245(1):36-43.

ReferenceCitation: Seror O, N'Kontchou G, Ibraheem M, Ajavon Y, Barrucand C, Ganne N, Coderc E, Trinchet JC, Beaugrand M, Sellier N. Large (>or=5.0-cm) HCCs: multipolar RF ablation with three internally cooled bipolar electrodes--initial experience in 26 patients. Radiology. 2008 Jul;248(1):288-96. doi: 10.1148/radiol.2481071101. Epub 2008 May 15.

ReferenceCitation: Wong IH, Yeo W, Leung T, Lau WY, Johnson PJ. Circulating tumor cell mRNAs in peripheral blood from hepatocellular carcinoma patients under radiotherapy, surgical resection or chemotherapy: a quantitative evaluation. Cancer Lett. 2001 Jun 26;167(2):183-91.


title: Randomized Comparison Between the STENTYS Self-expanding Coronary Stent and a Balloon-expandable Stent in Acute Myocardial Infarction - APPOSITION II

acronym: APPOSITION ll

summary: Study hypothesis: the Stentys self-expandable Stent results into a better alignment of the struts to the vessel wall than a balloon-expandable stent within a few days after the procedure in acute myocardial infarction patients.

ReferenceCitation: Nakatani S, Onuma Y, Ishibashi Y, Karanasos A, Regar E, Garcia-Garcia HM, Tamburino C, Fajadet J, Vrolix M, Witzenbichler B, Eeckhout E, Spaulding C, Reczuch K, La Manna A, Spaargaren R, Capodanno D, Van Langenhove G, Verheye S, Serruys PW, van Geuns RJ. Incidence and potential mechanism of resolved, persistent and newly acquired malapposition three days after implantation of self-expanding or balloon-expandable stents in a STEMI population: insights from optical coherence tomography in the APPOSITION II study. EuroIntervention. 2015 Dec;11(8):885-94. doi: 10.4244/EIJY15M11_01.

family: Nakatani

full_name: Shimpei Nakatani

given: Shimpei

family: Onuma

full_name: Yoshinobu Onuma

given: Yoshinobu

family: Ishibashi

full_name: Yuki Ishibashi

given: Yuki

family: Karanasos

full_name: Antonios Karanasos

given: Antonios

family: Regar

full_name: Evelyn Regar

given: Evelyn

family: Garcia-Garcia

full_name: Hector M. Garcia-Garcia

given: Hector M.

family: Tamburino

full_name: Corrado Tamburino

given: Corrado

family: Fajadet

full_name: Jean Fajadet

given: Jean

family: Vrolix

full_name: Mathias Vrolix

given: Mathias

family: Witzenbichler

full_name: Bernhard Witzenbichler

given: Bernhard

family: Eeckhout

full_name: Eric Eeckhout

given: Eric

family: Spaulding

full_name: Christian Spaulding

family: Reczuch

full_name: Krzysztof Reczuch

given: Krzysztof

family: La Manna

full_name: Alessio La Manna

given: Alessio

family: Spaargaren

full_name: René Spaargaren

given: René

family: Capodanno

full_name: Davide Capodanno

given: Davide

family: Van Langenhove

full_name: Glenn Van Langenhove

given: Glenn

family: Verheye

full_name: Stefan Verheye

given: Stefan

family: Serruys

full_name: Patrick W. Serruys

given: Patrick W.

family: van Geuns

full_name: Robert-Jan van Geuns

given: Robert-Jan

journal_name: EuroIntervention

publisher: Europa Digital & Publishing

publisher_dissemination: Europa Digital & Publishing

ReferenceCitation: van Geuns RJ, Tamburino C, Fajadet J, Vrolix M, Witzenbichler B, Eeckhout E, Spaulding C, Reczuch K, La Manna A, Spaargaren R, García-García HM, Regar E, Capodanno D, Van Langenhove G, Verheye S. Self-expanding versus balloon-expandable stents in acute myocardial infarction: results from the APPOSITION II study: self-expanding stents in ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2012 Dec;5(12):1209-19. doi: 10.1016/j.jcin.2012.08.016.

title: Self-Expanding Versus Balloon-Expandable Stents in Acute Myocardial Infarction: Results From the APPOSITION II Study


title: Evaluation of Low-energy Laser Therapy for Prevention and Reduction of Severity of Oral Mucositis in Children "Mucositis Laser 1"

summary: Oral mucositis represents a major complication of cytotoxic chemotherapy among cancer in children. Low-power laser therapy (LPLT) has been used to reduce the incidence of oral mucositis in patients who are receiving high-dose chemotherapy. The aim of this study is to compare two preventives energies delivered of LPLT to oral mucosa in decreasing the severity of mucositis in children.

status: Unknown status

study_completion_date_type: Anticipated


title: Sevoflurane Versus Propofol for Intubation in Neonatal Intensive Care

summary:
Endotracheal intubation is a painful and stressful procedure, which is associated with acute increases of blood pressure, intracranial pressure, bradycardia and hypoxemia with high morbidity.

The aim of the study is to compare recovery time, efficacy and tolerance in a randomized controlled study, between sevoflurane and propofol for intubation in neonates in Neonatal Intensive Care Unit.

lead_sponsor: Assistance Publique Hopitaux De Marseille

location_facility: Assistance Publique - Hôpitaux de Marseille


title: Determining the Minimum Effective Ropivacaine Dose for Unilateral Hypobaric Spinal Anaesthesia During Traumatic Femoral Neck Surgery in the Aged Person: Prospective Comparative Randomized Study

summary: This is a prospective, monocentric, randomized study, comparing the effectiveness and tolerance of four different dosages of hypobaric ropivacaine for unilateral spinal anaesthesia during traumatic femoral neck surgery in the elderly.

ReferenceCitation: Lilot M, Meuret P, Bouvet L, Caruso L, Dabouz R, Deléat-Besson R, Rousselet B, Thouverez B, Zadam A, Allaouchiche B, Boselli E. Hypobaric spinal anesthesia with ropivacaine plus sufentanil for traumatic femoral neck surgery in the elderly: a dose-response study. Anesth Analg. 2013 Jul;117(1):259-64. doi: 10.1213/ANE.0b013e31828f29f8. Epub 2013 Apr 16.

family: Lilot

full_name: Marc Lilot

given: Marc

family: Meuret

full_name: Pascal Meuret

given: Pascal

family: Bouvet

full_name: Lionel Bouvet

given: Lionel

family: Caruso

full_name: Liana Caruso

given: Liana

family: Dabouz

full_name: Rabia Dabouz

given: Rabia

family: Deléat-Besson

full_name: Robert Deléat-Besson

given: Robert

family: Rousselet

full_name: Bernard Rousselet

given: Bernard

family: Thouverez

full_name: Bruno Thouverez

given: Bruno

family: Zadam

full_name: Abbès Zadam

given: Abbès

family: Allaouchiche

full_name: Bernard Allaouchiche

family: Boselli

full_name: Emmanuel Boselli

given: Emmanuel

journal_name: Anesthesia & Analgesia

title: Hypobaric Spinal Anesthesia with Ropivacaine Plus Sufentanil for Traumatic Femoral Neck Surgery in the Elderly

lead_sponsor: Hospices Civils de Lyon


title: A Feasibility Study for Daily Use of a Brain Computer Interface for Communication in an ICU

summary: The main objective of this study is to evaluate the usability of a system to assist verbal communication based on BCI system using the P300 wave in patients with tetraplegia who can no longer communicate because of severe engine damage (tetraplegia) and respiratory damage requiring invasive mechanical ventilation (intubation or tracheostomy) preventing verbal communication.

location_facility: Service de reanimation, Hopital Raymond Poincare


title: Double-Blind Phase II Pilot Monocentric Randomized Clinical Trial Evaluating the Effect of a Preliminary Administration of Cyclosporine on Different Markers of Cardiac Ischemia Led by the Aortic Cross-clamp During Coronary Artery Bypass Surgery With Cardiopulmonary Bypass.

acronym: Ciclo et CEC

summary: Observe the effect of preliminary cyclosporine administration on different markers of cardiac ischaemia led by the aortic cross-clamp during coronary artery bypass surgery with Cardiopulmonary bypass.

ReferenceCitation: Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. 1999 Jul 15;341 ( Pt 2):233-49. Review.

ReferenceCitation: Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. Cardiovasc Res. 2004 Feb 15;61(3):372-85. Review.

ReferenceCitation: Hausenloy DJ, Duchen MR, Yellon DM. Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res. 2003 Dec 1;60(3):617-25.

ReferenceCitation: Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM. Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H237-42.

ReferenceCitation: Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, André-Fouët X, Revel D, Kirkorian G, Monassier JP, Derumeaux G, Ovize M. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med. 2008 Jul 31;359(5):473-81. doi: 10.1056/NEJMoa071142.

lead_sponsor: University Hospital, Grenoble

location_facility: Department of cardiac surgery - University Hospital of Grenoble


title: A Prospective Randomized Study to Evaluate the Clinical Impact of a Laparoscopic Radical Prostatectomy Online Simulator

acronym: PERLE

summary: To evaluate the clinical impact of an online video simulator during the learning period of laparoscopic radical prostatectomy.

status: Suspended

lead_sponsor: Assistance Publique - Hôpitaux de Paris


title: Genetic Study of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

acronym: DVDA

summary: The purpose of this trial is to study the genetic and phenotypic aspects of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C), and determine the impact of genetic testing in clinical practice.


title: High Dose of Erythropoietin Analogue After Cardiac Arrest: a Multicentre, Randomised, Controlled Trial (Epo-ACR-02 Trial)

summary: The investigators hypothesised that the neuroprotective effects of erythropoietin and its analogues could lead to an improve outcome after cardiac arrest. To test this hypotheses, the investigators designed a randomized, multicentre, simple blind trial in which all participating patients will be receive usual treatments and 50% of them will also receive a high dose of epoetin alpha (an analogue of erythropoietin) in an "add on" fashion. The main end point will be the proportion of patients in each arm who will reach at day 60 the best level of recovery, using a 5 level score.

ReferenceCitation: Madelaine T, Cour M, Roy P, Vivien B, Charpentier J, Dumas F, Deye N, Bonnefoy E, Gueugniaud PY, Coste J, Cariou A, Argaud L. Prediction of Brain Death After Out-of-Hospital Cardiac Arrest: Development and Validation of the Brain Death After Cardiac Arrest Score. Chest. 2021 Jul;160(1):139-147. doi: 10.1016/j.chest.2021.01.056. Epub 2021 Jun 8.

family: Madelaine

full_name: Thomas Madelaine

given: Thomas

family: Cour

full_name: Martin Cour

given: Martin

family: Roy

full_name: Pascal Roy

family: Vivien

full_name: Benoît Vivien

given: Benoît

family: Charpentier

full_name: Julien Charpentier

given: Julien

family: Dumas

full_name: Florence Dumas

given: Florence

family: Deye

full_name: Nicolas Deye

given: Nicolas

family: Bonnefoy

full_name: Eric Bonnefoy

given: Eric

family: Gueugniaud

full_name: Pierre-Yves Gueugniaud

given: Pierre-Yves

family: Coste

full_name: Joël Coste

given: Joël

family: Cariou

full_name: Alain Cariou

given: Alain

family: Argaud

full_name: Laurent Argaud

given: Laurent

journal_name: Chest

ReferenceCitation: Boissady E, Kohlhauer M, Lidouren F, Hocini H, Lefebvre C, Chateau-Jouber S, Mongardon N, Deye N, Cariou A, Micheau P, Ghaleh B, Tissier R. Ultrafast Hypothermia Selectively Mitigates the Early Humoral Response After Cardiac Arrest. J Am Heart Assoc. 2020 Dec;9(23):e017413. doi: 10.1161/JAHA.120.017413. Epub 2020 Nov 17.

apc_source: openAPC

name: INSERMIMRBEcole Nationale Vétérinaire d’AlfortUniv Paris Est Creteil Creteil France

family: Boissady

full_name: Emilie Boissady

given: Emilie

family: Kohlhauer

full_name: Matthias Kohlhauer

given: Matthias

family: Lidouren

full_name: Fanny Lidouren

given: Fanny

name: Vaccine Research Institute Univ Paris Est‐Creteil Creteil France

family: Hocini

full_name: Hakim Hocini

given: Hakim

family: Lefebvre

full_name: Cécile Lefebvre

given: Cécile

family: Chateau‐Jouber

full_name: Sophie Chateau‐Jouber

given: Sophie

name: Service d’anesthésie‐Réanimation Chirurgicale DMU CARE APHPHôpitaux Universitaires Henri Mondor Créteil France

family: Mongardon

full_name: Nicolas Mongardon

name: Medical ICU Inserm U942 Lariboisiere HospitalAPHP Paris France

name: Service de Réanimation Médicale Hôpitaux Universitaires Paris CentreHopital Cochin Paris France

name: Groupe Inolivent Université de Sherbrooke Sherbrooke Quebec Canada

journal_name: Journal of the American Heart Association

ReferenceCitation: Cariou A, Deye N, Vivien B, Richard O, Pichon N, Bourg A, Huet L, Buleon C, Frey J, Asfar P, Legriel S, Narcisse S, Mathonnet A, Cravoisy A, Dequin PF, Wiel E, Razazi K, Daubin C, Kimmoun A, Lamhaut L, Marx JS, de la Garanderie DP, Ecollan P, Combes A, Spaulding C, Barat F, Ben Boutieb M, Coste J, Chiche JD, Pène F, Mira JP, Treluyer JM, Hermine O, Carli P; Epo-ACR-02 Study Group. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. J Am Coll Cardiol. 2016 Jul 5;68(1):40-9. doi: 10.1016/j.jacc.2016.04.040.

journal_name: Journal of the American College of Cardiology

location_facility: Medical intensive care unit of Cochin-St Vincent de Paul university Hospital


title: Preventive Administration of N-acetyl-cysteine (NAC) in Organ Donor: Effects on Kidney Graft Function

summary: The goal of this study is to evaluate the effect of N-acetyl-cysteine (NAC) administration in organ donors on the kidney graft function of recipients.

ReferenceCitation: Orban JC, Quintard H, Cassuto E, Jambou P, Samat-Long C, Ichai C. Effect of N-acetylcysteine pretreatment of deceased organ donors on renal allograft function: a randomized controlled trial. Transplantation. 2015 Apr;99(4):746-53. doi: 10.1097/TP.0000000000000395.

family: Orban

full_name: Jean-Christophe Orban

given: Jean-Christophe

family: Quintard

full_name: Hervé Quintard

given: Hervé

family: Cassuto

full_name: Elisabeth Cassuto

given: Elisabeth

family: Jambou

full_name: Patrick Jambou

given: Patrick

family: Samat-Long

full_name: Corine Samat-Long

given: Corine

family: Ichai

full_name: Carole Ichai

given: Carole

journal_name: Transplantation

oa_host_type: repository

license: implied-oa

license_normalized: implied-oa

title: Effect of N-Acetylcysteine Pretreatment of Deceased Organ Donors on Renal Allograft Function

lead_sponsor: Institut d'Anesthesiologie des Alpes Maritimes


title: Phase 2 Study of Oral AB1010 in Non Pre-treated, Inoperable Patients With Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)

summary: The objective is to evaluate the efficacy and safety of AB1010 at 7.5 mg/kg/day in the treatment of non pre-treated, inoperable patients with locally advanced/metastatic GIST.

ReferenceCitation: Le Cesne A, Blay JY, Bui BN, Bouché O, Adenis A, Domont J, Cioffi A, Ray-Coquard I, Lassau N, Bonvalot S, Moussy A, Kinet JP, Hermine O. Phase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Eur J Cancer. 2010 May;46(8):1344-51. doi: 10.1016/j.ejca.2010.02.014. Epub 2010 Mar 6.

family: Le Cesne

full_name: Axel Le Cesne

given: Axel

family: Blay

full_name: Jean-Yves Blay

given: Jean-Yves

family: Bui

full_name: Binh Nguyen Bui

given: Binh Nguyen

family: Bouché

full_name: Olivier Bouché

given: Olivier

family: Adenis

full_name: Antoine Adenis

given: Antoine

family: Domont

full_name: Julien Domont

given: Julien

family: Cioffi

full_name: Angela Cioffi

given: Angela

family: Ray-Coquard

full_name: Isabelle Ray-Coquard

given: Isabelle

family: Lassau

full_name: Nathalie Lassau

given: Nathalie

family: Bonvalot

full_name: Sylvie Bonvalot

given: Sylvie

family: Moussy

full_name: Alain Moussy

family: Kinet

full_name: Jean-Pierre Kinet

given: Jean-Pierre

family: Hermine

full_name: Olivier Hermine

journal_name: European Journal of Cancer

lead_sponsor: AB Science


type: EudraCT Number

title: Phase I Dose Escalation Study of Concomitant BIBF 1120 and BIBW 2992 in Patients With Advanced Solid Tumours.

summary: The primary objective of this trial is to determine the Maximum Tolerated Dose (MTD) of the combination of BIBW 2992/BIBF 1120 therapy administered concomitantly. The MTD will provide dosing recommendation for subsequent phase II trials in patients with metastatic cancer.

ReferenceCitation: Bahleda R, Hollebecque A, Varga A, Gazzah A, Massard C, Deutsch E, Amellal N, Farace F, Ould-Kaci M, Roux F, Marzin K, Soria JC. Phase I study of afatinib combined with nintedanib in patients with advanced solid tumours. Br J Cancer. 2015 Nov 17;113(10):1413-20. doi: 10.1038/bjc.2015.374. Epub 2015 Oct 29.

family: Bahleda

full_name: Rastislav Bahleda

given: Rastislav

family: Hollebecque

full_name: Antoine Hollebecque

family: Varga

full_name: Andrea Varga

given: Andrea

family: Gazzah

full_name: Anas Gazzah

given: Anas

family: Massard

full_name: Christophe Massard

given: Christophe

family: Deutsch

full_name: Eric Deutsch

given: Eric

family: Amellal

full_name: Nadia Amellal

given: Nadia

family: Farace

full_name: Françoise Farace

given: Françoise

family: Ould-Kaci

full_name: Mahmoud Ould-Kaci

given: Mahmoud

family: Roux

full_name: Flavien Roux

given: Flavien

family: Marzin

full_name: Kristell Marzin

given: Kristell

family: Soria

full_name: Jean-Charles Soria

given: Jean-Charles

journal_name: British Journal of Cancer

oa_colors: green hybrid

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

lead_sponsor: Boehringer Ingelheim

location_facility: 1239.14.3301A Boehringer Ingelheim Investigational Site


title: Major Depression and Messenger RNAs

summary: Major Depressive Episode (MDE) affects nearly 15% of the general population. In a preliminary study, the investigators identified 12 genes whose expression was either altered between patient and control samples and/or between first patient samples and samples from the same patients obtained 8 weeks later. However, this study did not assess evolution of these alterations beyond an 8-week window and only 2 time points were considered. The investigators aim to compare gene expression difference for 21 candidate genes, of which 12 were already investigated, in 2 groups of subjects. MDE and control samples will be analyzed across a large time window to draw a better picture of the complex progression during MDE.

location_facility: Assistance Publique-Hôpitaux de Marseille

intervention_type: Biological


title: Impact of Adipose Tissue Repartition on the Time Course of Vascular Dysfunction - the NUMEVOX Cohort

acronym: NUMEVOX

summary: The NUMEVOX cohort is intended to follow-up the macro and microvascular dysfunction in relation to adipose tissue repartition in patients with metabolic syndrome associated to liver steatosis, sleep apnea. Duration of the follow-up is 3 years for each patient entering the cohort.

lead_sponsor: University Hospital, Angers

location_facility: Pôle Maladies Métaboliques et Médecine Interne


title: Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury

summary: The goal of this study is to evaluate the effect of preventive intravenous infusion of half molar sodium lactate on the onset of hypertensive intracranial episodes in severe head trauma. The investigators hypothesize that preventive intravenous administration of sodium lactate will decrease the number of treatments required to decrease intracranial pressure during 48 hours.

ReferenceCitation: Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, Grimaud D, Leverve X. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med. 2009 Mar;35(3):471-9. doi: 10.1007/s00134-008-1283-5. Epub 2008 Sep 20.

family: Ichai

full_name: Carole Ichai

given: Carole

family: Armando

full_name: Guy Armando

given: Guy

family: Orban

full_name: Jean-Christophe Orban

given: Jean-Christophe

family: Berthier

full_name: Frederic Berthier

given: Frederic

family: Rami

full_name: Laurent Rami

given: Laurent

family: Samat-Long

full_name: Corine Samat-Long

given: Corine

family: Grimaud

full_name: Dominique Grimaud

given: Dominique

family: Leverve

full_name: Xavier Leverve

given: Xavier

location_facility: Institut d'Anesthesiologie des Alpes maritimes


title: Comparison of 20-core vs 12-core Prostate Biopsy Diagnostic Performance in the Detection of Prostate Cancer

summary: The optimal number of prostate cores extracted during a prostate biopsy performed because of a suspected prostate cancer is still debated. The present consensus is to sample 12 cores. However, recent data published in the literature brought arguments in favour of a higher number, probably 20. This would have the advantages of decreasing the false negatives and the re-biopsy rate.

ReferenceCitation: Irani J, Blanchet P, Salomon L, Coloby P, Hubert J, Malavaud B, Mottet N. Is an extended 20-core prostate biopsy protocol more efficient than the standard 12-core? A randomized multicenter trial. J Urol. 2013 Jul;190(1):77-83. doi: 10.1016/j.juro.2012.12.109. Epub 2013 Jan 9.

name: Department of Urology, CHU La Miletrie, Poitiers, France

family: Irani

full_name: Jacques Irani

given: Jacques

name: CHU, Pointre-à-Pitre, Guadeloupe, France

family: Blanchet

full_name: Pascal Blanchet

given: Pascal

family: Salomon

full_name: Laurent Salomon

family: Coloby

full_name: Patrick Coloby

given: Patrick

family: Hubert

full_name: Jacques Hubert

family: Malavaud

full_name: Bernard Malavaud

given: Bernard

family: Mottet

full_name: Nicolas Mottet

given: Nicolas

journal_name: Journal of Urology

title: Is an Extended 20-Core Prostate Biopsy Protocol More Efficient than the Standard 12-Core? A Randomized Multicenter Trial

lead_sponsor: Poitiers University Hospital

location_facility: service d'Urologie - CHU de Poitiers - 2 rue de la Milétrie


title: Comparative, Randomized, Double-blind, Placebo-controlled, Parallel Group Study, to Evaluate the Efficacy of a Turmeric Extract (Arantal®) Versus Placebo in Patients With Osteoarthritis of the Knee (Gonarthrosis).

summary: The purpose of this study is to determine the efficacy and the tolerance on 15 days of a turmeric extract (Arantal®) on pain related to gonarthrosis.

lead_sponsor: Bioxtract SA

intervention_type: Dietary Supplement


title: A Phase 1, Multi-center, Randomized, Double-Blind, Placebo-controlled, Dose-escalation Safety Assessment Study of Combination Treatment With IMO-2125 and Ribavirin in Naïve Hepatitis C-infected, Genotype 1 Patients

summary: Phase 1, randomized, double-blind, placebo-controlled, dose-escalation study with 3 dose levels of IMO-2125 in combination with standard weight based ribavirin (investigational treatment arm) or placebo in combination with ribavirin (RBV). Each cohort of 15 patients will be randomized 4:1 to receive the investigational treatment arm (12 patients) or placebo and RBV arm (3 patients).

lead_sponsor: Idera Pharmaceuticals, Inc.


ReferenceCitation: Mancini J, Dubus JC, Jouve E, Roux JC, Franco P, Lagrue E, Castelnau P, Cances C, Chaix Y, Rougeot-Jung C, Cornu C, Desportes V, Vallée L, Bahi-Buisson N, Truillet R, Attolini L, Villard L, Blin O, Micallef J. Effect of desipramine on patients with breathing disorders in RETT syndrome. Ann Clin Transl Neurol. 2017 Dec 27;5(2):118-127. doi: 10.1002/acn3.468. eCollection 2018 Feb.

name: Neuropediatric Unit; Aix Marseille University; Children Hospital; APHM, Timone, Neurosciences Institute; Marseille France

family: Mancini

full_name: Josette Mancini

given: Josette

name: Pneumology Pediatric Unit; Aix Marseille University; Children Hospital; CNRS URMITE 6236; APHM; Marseille France

family: Dubus

full_name: Jean-Christophe Dubus

name: Department of Pharmacology; F-CRIN OrphanDEV; Timone Neurosciences Institute; Aix Marseille University; CNRS; INT; APHM, CIC CPCET; CHU Timone; Marseille France

family: Jouve

full_name: Elisabeth Jouve

given: Elisabeth

name: Aix Marseille University; INSERM, GMGF UMR_S 910; Marseille France

family: Roux

full_name: Jean-Christophe Roux

name: Neuropediatric Ward; Hypnology Unit; Lyon University; Civil Hospices of Lyon; INSERM U628; Lyon France

family: Franco

full_name: Patricia Franco

given: Patricia

name: Neuropediatrics and Handicap Department; Tours University; INSERM, UMR U930 Imaging and Brain, CHRU Tours; Tours France

family: Lagrue

full_name: Emmanuelle Lagrue

given: Emmanuelle

family: Castelnau

full_name: Pierre Castelnau

given: Pierre

name: Neuropediatric Unit; NeuroImaging Center; Toulouse University; Children Hospital CHU PURPAN; UMR1214; Toulouse France

family: Cances

full_name: Claude Cances

given: Claude

family: Chaix

full_name: Yves Chaix

given: Yves

name: Lyon University; National Reference Center for Rare Diseases with Intellectual Disability; HFME; Hospices Civils de Lyon; Lyon France

family: Rougeot-Jung

full_name: Christelle Rougeot-Jung

given: Christelle

name: Department of Pharmacotoxicology; Clinical Investigation Center; Hospices Civils de Lyon; INSERM 1407; Lyon France

name: Lyon University; CNRS UMR 5558; Lyon France

family: Cornu

full_name: Catherine Cornu

given: Catherine

family: Desportes

full_name: Vincent Desportes

given: Vincent

name: Department of Neuropediatrics; Lille North 2 University; CHRU; Hôpital Roger Salengro; Lille France

family: Vallée

full_name: Louis Vallée

given: Louis

name: Imagine Institute and INSERM UMR-1163; Embryology and Genetics of Congenital Malformations; Pediatric Neurology; Paris Descartes - Sorbonne Paris Cité University; Necker Enfants Malades University Hospital; AP-HP; Paris France

family: Bahi-Buisson

full_name: Nadia Bahi-Buisson

given: Nadia

family: Truillet

full_name: Romain Truillet

given: Romain

family: Attolini

full_name: Laurence Attolini

given: Laurence

family: Villard

full_name: Laurent Villard

family: Blin

full_name: Olivier Blin

given: Olivier

family: Micallef

full_name: Joëlle Micallef

given: Joëlle

journal_name: Annals of Clinical and Translational Neurology

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Francois Rabelais - Tours

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

location_facility: Assistance Publique - Hopitaux de Marseille

title: Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome

summary:
Rett syndrome is a neurodevelopmental disorder characterized by cognitive impairment, communication dysfunction, stereotypic movement disorder, and growth failure. Rett syndrome is caused by mutations in the Methyl CpG-Binding Protein-2 (MECP2) gene and has no treatment.

A mouse experimental model of Rett syndrome created by genetic invalidation of the MECP2 gene is available. It had been then observed that adult MECP2-deficient mice show respiratory alterations and found that endogenous noradrenaline helps to maintain a normal respiratory rhythm. Desipramine, a selective inhibitor of norepinephrine reuptake, seems to be efficient to reduce the respiratory alteration occuring in MECP2-deficient mice (Insem patent 2005, Villard and Roux 2006).

The aim of the study is to evaluate these obtained results in MECP2-deficient mice on patients with Rett syndrome.


title: Impact of Neuropathic Post-zosterian Pain on the Cognition (NPZ and Cognition)

summary: Pain is defined as a sensorial and emotional phenomenon and lead consequences on the cognition. These consequences could be increased with usual treatment. So the aim of this study is to explore these cognitive consequences.

time_perspective: Cross-Sectional

ReferenceCitation: Pickering G, Pereira B, Clère F, Sorel M, de Montgazon G, Navez M, Picard P, Roux D, Morel V, Salimani R, Adda M, Legout V, Dubray C. Cognitive function in older patients with postherpetic neuralgia. Pain Pract. 2014 Jan;14(1):E1-7. doi: 10.1111/papr.12079. Epub 2013 May 23.

name: CHU Clermont-Ferrand; Centre de Pharmacologie Clinique; Clermont-Ferrand France

name: Inserm; CIC 501; UMR 766; Clermont-Ferrand France

name: Clermont Université; Laboratoire de Pharmacologie; Faculté de médecine; Clermont-Ferrand France

family: Pickering

full_name: Gisèle Pickering

given: Gisèle

family: Pereira

full_name: Bruno Pereira

given: Bruno

name: Chateauroux Hospital; Chateauroux France

family: Clère

full_name: Florentin Clère

given: Florentin

family: Sorel

full_name: Marc Sorel

given: Marc

name: La Rochelle Hospital; La Rochelle France

family: de Montgazon

full_name: Geraldine de Montgazon

given: Geraldine

name: Saint-Etienne Hospital; Saint-Etienne France

family: Navez

full_name: Malou Navez

given: Malou

name: Clermont-Ferrand Hospital; Clermont-Ferrand France

family: Picard

full_name: Pascale Picard

given: Pascale

full_name: Delphine Roux

given: Delphine

family: Morel

full_name: Véronique Morel

given: Véronique

family: Salimani

full_name: Rachida Salimani

given: Rachida

family: Adda

full_name: Mireille Adda

given: Mireille

family: Legout

full_name: Valérie Legout

given: Valérie

family: Dubray

full_name: Claude Dubray

journal_name: Pain Practice

title: Cognitive Function in Older Patients with Postherpetic Neuralgia

lead_sponsor: University Hospital, Clermont-Ferrand


title: Amplifying Graft-versus-tumor Effect by Donor Regulatory T-cell Depletion Before Donor Lymphocytes Infusion: a Phase I/II Clinical Study

acronym: ILD-Treg

summary: The investigators have previously shown that depletion of CD4+CD25+FoxP3+ regulatory T cells (Treg) enhances the alloreactivity of T lymphocytes, as attested by an accelerated GVHD after allogeneic hematopoietic stem cell transplantation (HSCT) in mice. The investigators thus propose a clinical trial to test whether Treg-depleted donor lymphocytes infusion (dDLI) could induce an improved graft-versus-tumor (GVT) effect in patients refractory to standard DLI (stdDLI) for treatment of relapse after HSCT.

ReferenceCitation: Maury S, Lemoine FM, Hicheri Y, Rosenzwajg M, Badoual C, Cheraï M, Beaumont JL, Azar N, Dhedin N, Sirvent A, Buzyn A, Rubio MT, Vigouroux S, Montagne O, Bories D, Roudot-Thoraval F, Vernant JP, Cordonnier C, Klatzmann D, Cohen JL. CD4+CD25+ regulatory T cell depletion improves the graft-versus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation. Sci Transl Med. 2010 Jul 21;2(41):41ra52. doi: 10.1126/scitranslmed.3001302.

name: Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

name: Université Paris-Est Créteil Val de Marne, Créteil F-94010, France.

family: Maury

full_name: Sébastien Maury

given: Sébastien

name: Department of Biotherapies, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.

name: Centre National de la Recherche Scientifique UMR 7211, Université Pierre et Marie Curie Paris 06, Paris F-75013, France.

family: Lemoine

full_name: François M. Lemoine

given: François M.

family: Hicheri

full_name: Yosr Hicheri

given: Yosr

family: Rosenzwajg

full_name: Michelle Rosenzwajg

given: Michelle

name: Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris F-75015, France.

name: Ecole Nationale Vétérinaire d’Alfort, EA4054, Paris Descartes University, Paris F-75005, France.

family: Badoual

full_name: Cécile Badoual

given: Cécile

family: Cheraï

full_name: Mustapha Cheraï

given: Mustapha

name: Department of Hemapheresis, Etablissement Français du Sang d’Ile de France, Créteil F-94010, France.

family: Beaumont

full_name: Jean-Louis Beaumont

given: Jean-Louis

family: Azar

full_name: Nabih Azar

given: Nabih

name: Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.

family: Dhedin

full_name: Nathalie Dhedin

given: Nathalie

name: Department of Hematology, Hôpital Archet, Nice F-06000, France.

family: Sirvent

full_name: Anne Sirvent

given: Anne

name: Department of Hematology, Hôpital Necker, Paris F-75015, France.

family: Buzyn

full_name: Agnès Buzyn

given: Agnès

family: Rubio

full_name: Marie-Thérèse Rubio

given: Marie-Thérèse

name: Department of Hematology, Hôpital Haut-Leveque, Bordeaux F-33000, France.

family: Vigouroux

full_name: Stéphane Vigouroux

given: Stéphane

name: Center for Clinical Investigation in Biotherapy, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

family: Montagne

full_name: Olivier Montagne

family: Bories

full_name: Dominique Bories

given: Dominique

name: Department of Public Health, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

family: Roudot-Thoraval

full_name: Françoise Roudot-Thoraval

given: Françoise

family: Vernant

full_name: Jean-Paul Vernant

given: Jean-Paul

family: Cordonnier

full_name: Catherine Cordonnier

given: Catherine

family: Klatzmann

full_name: David Klatzmann

given: David

family: Cohen

full_name: José L. Cohen

given: José L.

journal_name: Science Translational Medicine

publisher: American Association for the Advancement of Science (AAAS)

title: CD4 + CD25 + Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation


title: Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye

summary: This study will evaluate the safety and efficacy of OPTIVE® MD for ocular surface integrity in symptomatic dry eye condition in absence of obvious eye-lid inflammation.

lead_sponsor: Allergan


title: Randomised Multicenter Trial of Early EUS Followed by Endoscopic Sphincterotomy in Case of Bile Duct Stone vs Conservative Treatment in Severe Biliary Pancreatitis

summary: The primary purpose of this trial is to determine whether an early Early Endoscopic Ultrasound (EUS) immediately followed by an endoscopic sphincterotomy (ES) in case of bile duct stones may improve outcomes in patients with predicted severe acute biliary pancreatitis (ABP).


title: Replace Sandostatine® in Three Daily Subcutaneous Injections by a Single Intramuscular Injection of Sandostatine® LP Per Month in Patients With a Diffuse Form of Hyperinsulinism

summary: To replace Sandostatine® in three daily subcutaneous injections by a single intramuscular injection of Sandostatine® LP per month in patients with a diffuse form of hyperinsulinism.


title: Comparison of Two Tapering Strategies of Prednisone in Patients With Generalised Myasthenia Gravis Treated With Prednisone and Azathioprine: a Single-blind Randomised Controlled Multicenter Study

acronym: MYACOR

summary:
Pathology - Generalized myasthenia gravis (MG) is cause of muscle weakness that can have a significant impact on daily life activity but can also be, when respiratory or bulbar muscles are involved, life-threatening.

Rationale - Additionally to thymectomy, which indication of is still debated in absence of thymoma, the long-term treatment of generalized myasthenia gravis includes usually prednisone and azathioprine. However, the most used scheme for prescribing and tapering corticosteroid in MG resulted in a very important cumulative dose of prednisone. Indeed, at twelve month, more than 50 percent of patients are still daily treated with at least 18 mg of prednisone and the proportion of patients who are in remission and no longer taking prednisone is very low (Palace and NEWSOM Davis, Neurology 1998). Prolonged corticosteroid therapy is accompanied with various and major side effects, hypertension, osteoporosis, weight gain, glaucoma. Therefore, tapering, eventually discontinuing, prednisone earlier is a relevant therapeutic goal.

For this reason, the investigators will compare to the standard one, a strategy consisting of a rapid decrease in corticosteroid.

Objective - To assess whether, in patients with generalized MG requiring a long-term treatment with corticosteroids and azathioprine, that the strategy of rapid tapering allows discontinuing more rapidly the prednisone for equivalent efficacy than the classical strategy.

ReferenceCitation: Sharshar T, Porcher R, Demeret S, Tranchant C, Gueguen A, Eymard B, Nadaj-Pakleza A, Spinazzi M, Grimaldi L, Birnbaum S, Friedman D, Clair B; MYACOR Study Group. Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis: A Randomized Clinical Trial. JAMA Neurol. 2021 Apr 1;78(4):426-433. doi: 10.1001/jamaneurol.2020.5407.

name: Neuro-anesthesiology and Intensive Care Medicine, GHU-Paris, Sainte-Anne Hospital, Paris-17 Université de Paris, Paris, France

name: General Intensive Care Unit, APHP, Raymond Poincaré Hospital, University of Versailles Saint-Quentin en Yvelines, Garches, France

name: Experimental Neuropathology, Infection and Epidemiology Department, Institut Pasteur, Paris, France

family: Sharshar

full_name: Tarek Sharshar

given: Tarek

name: Center for Clinical Epidemiology, Assistance Publique Hôpitaux de Paris, Hôtel Dieu Hospital, University Paris Descartes–France, Paris, France

family: Porcher

full_name: Raphaël Porcher

given: Raphaël

name: Department of Neurology, Neuro-ICU, APHP-Paris-Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France

family: Demeret

full_name: Sophie Demeret

given: Sophie

name: Department of Neurology, University Hospital, Strasbourg, France

family: Tranchant

full_name: Christine Tranchant

given: Christine

name: Department of Neurology, Rothschild Ophthalmologic Foundation, Paris, France

family: Gueguen

full_name: Antoine Gueguen

given: Antoine

family: Eymard

full_name: Bruno Eymard

given: Bruno

name: France Department of Neurology, University Hospital, Angers, France

family: Nadaj-Pakleza

full_name: Aleksandra Nadaj-Pakleza

given: Aleksandra

family: Spinazzi

full_name: Marco Spinazzi

given: Marco

name: Clinical Research Unit, Ambroise Paré Hospital, University of Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, France

family: Grimaldi

full_name: Lamiae Grimaldi

given: Lamiae

name: Neuromuscular Investigation Centre, Institute of Myology, Pitié-Salpêtrière Hospital, Paris, France

family: Birnbaum

full_name: Simone Birnbaum

given: Simone

family: Friedman

full_name: Diane Friedman

given: Diane

family: Clair

full_name: Bernard Clair

given: Bernard

family: Aegerter

full_name: Philippe Aegerter

given: Philippe

family: Annane

full_name: Djillali Annane

given: Djillali

family: Aubé-Nathier

full_name: Anne-Catherine Aubé-Nathier

given: Anne-Catherine

family: Bolgert

full_name: Francis Bolgert

given: Francis

family: Fleury

full_name: Marie Fleury

given: Marie

family: Durand

full_name: Marie-Christine Durand

given: Marie-Christine

family: Gonnaud

full_name: Pierre-Marie Gonnaud

given: Pierre-Marie

family: Goulon-Goeau

full_name: Catherine Goulon-Goeau

family: Gout

full_name: Olivier Gout

given: Olivier

family: Lofaso

full_name: Frédéric Lofaso

given: Frédéric

family: Marcel

full_name: Christophe Marcel

given: Christophe


title: Validation of the Sentinel Node in Endometrial Cancer

acronym: Senti-Endo

summary: The purpose of this study is to investigate the relevance of sentinel node in endometrial cancer. Sentinel node is thought to reflect the status of lymph node. Only 10 to 20% of women with endometrial cancer exhibit lymph node metastasis hence systematic lymphadenectomy is questionable. In breast cancer, melanoma and vulvar cancer, sentinel node has emerged as an alternative to complete lymphadenectomy.

ReferenceCitation: Daraï E, Dubernard G, Bats AS, Heitz D, Mathevet P, Marret H, Querleu D, Golfier F, Leblanc E, Rouzier R, Ballester M. Sentinel node biopsy for the management of early stage endometrial cancer: long-term results of the SENTI-ENDO study. Gynecol Oncol. 2015 Jan;136(1):54-9. doi: 10.1016/j.ygyno.2014.09.011. Epub 2014 Oct 22.

family: Daraï

full_name: Emile Daraï

given: Emile

family: Dubernard

full_name: Gil Dubernard

given: Gil

family: Bats

full_name: Anne-Sophie Bats

given: Anne-Sophie

family: Heitz

full_name: Denis Heitz

given: Denis

family: Mathevet

full_name: Patrice Mathevet

given: Patrice

family: Marret

full_name: Henri Marret

given: Henri

family: Querleu

full_name: Denis Querleu

family: Golfier

full_name: François Golfier

given: François

family: Leblanc

full_name: Eric Leblanc

given: Eric

family: Rouzier

full_name: Roman Rouzier

given: Roman

family: Ballester

full_name: Marcos Ballester

given: Marcos

journal_name: Gynecologic Oncology

title: Sentinel node biopsy for the management of early stage endometrial cancer: Long-term results of the SENTI-ENDO study

ReferenceCitation: Ballester M, Dubernard G, Lécuru F, Heitz D, Mathevet P, Marret H, Querleu D, Golfier F, Leblanc E, Rouzier R, Daraï E. Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol. 2011 May;12(5):469-76. doi: 10.1016/S1470-2045(11)70070-5. Epub 2011 Apr 12.

family: Lécuru

full_name: Fabrice Lécuru

given: Fabrice


title: Efficacy of Terlipressin in Cirrhotic Patients With Recidivation Ascites Treated With Paracentesis and Albumin. A Multi-center Randomized Controlled Study

acronym: TERAS

summary: Ascites is a common complication of cirrhosis. Sodium restriction and diuretics are the first step treatment. Refractory ascites (not responding to first step treatment) is treated with repeated large volume paracentesis followed by intra venous albumin expansion. In pilot studies vasoconstrictor agents such as terlipressin have shown beneficial effect on ascites production. Therefore the investigators will study the effect of combined therapy with albumin and terlipressin on recidivation ascites.

ReferenceCitation: Runyon BA. Management of adult patients with ascites caused by cirrhosis. Hepatology. 1998 Jan;27(1):264-72. Review.

ReferenceCitation: Ginés P, Quintero E, Arroyo V, Terés J, Bruguera M, Rimola A, Caballería J, Rodés J, Rozman C. Compensated cirrhosis: natural history and prognostic factors. Hepatology. 1987 Jan-Feb;7(1):122-8.

ReferenceCitation: Moore KP, Wong F, Gines P, Bernardi M, Ochs A, Salerno F, Angeli P, Porayko M, Moreau R, Garcia-Tsao G, Jimenez W, Planas R, Arroyo V. The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club. Hepatology. 2003 Jul;38(1):258-66. Review.

ReferenceCitation: Ginès A, Fernández-Esparrach G, Monescillo A, Vila C, Domènech E, Abecasis R, Angeli P, Ruiz-Del-Arbol L, Planas R, Solà R, Ginès P, Terg R, Inglada L, Vaqué P, Salerno F, Vargas V, Clemente G, Quer JC, Jiménez W, Arroyo V, Rodés J. Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology. 1996 Oct;111(4):1002-10.

ReferenceCitation: Ruiz-del-Arbol L, Monescillo A, Jimenéz W, Garcia-Plaza A, Arroyo V, Rodés J. Paracentesis-induced circulatory dysfunction: mechanism and effect on hepatic hemodynamics in cirrhosis. Gastroenterology. 1997 Aug;113(2):579-86.

ReferenceCitation: Ginès P, Titó L, Arroyo V, Planas R, Panés J, Viver J, Torres M, Humbert P, Rimola A, Llach J, et al. Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis. Gastroenterology. 1988 Jun;94(6):1493-502.

ReferenceCitation: Moreau R, Lebrec D. The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond. Hepatology. 2006 Mar;43(3):385-94. Review.

ReferenceCitation: Moreau R, Valla DC, Durand-Zaleski I, Bronowicki JP, Durand F, Chaput JC, Dadamessi I, Silvain C, Bonny C, Oberti F, Gournay J, Lebrec D, Grouin JM, Guémas E, Golly D, Padrazzi B, Tellier Z. Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trail. Liver Int. 2006 Feb;26(1):46-54.

ReferenceCitation: Moreau R, Asselah T, Condat B, de Kerguenec C, Pessione F, Bernard B, Poynard T, Binn M, Grangé JD, Valla D, Lebrec D. Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study. Gut. 2002 Jan;50(1):90-4.

ReferenceCitation: Singh V, Kumar R, Nain CK, Singh B, Sharma AK. Terlipressin versus albumin in paracentesis-induced circulatory dysfunction in cirrhosis: a randomized study. J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 2):303-7.

ReferenceCitation: Solanki P, Chawla A, Garg R, Gupta R, Jain M, Sarin SK. Beneficial effects of terlipressin in hepatorenal syndrome: a prospective, randomized placebo-controlled clinical trial. J Gastroenterol Hepatol. 2003 Feb;18(2):152-6.

ReferenceCitation: Ortega R, Ginès P, Uriz J, Cárdenas A, Calahorra B, De Las Heras D, Guevara M, Bataller R, Jiménez W, Arroyo V, Rodés J. Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study. Hepatology. 2002 Oct;36(4 Pt 1):941-8.

ReferenceCitation: Moreau R, Durand F, Poynard T, Duhamel C, Cervoni JP, Ichaï P, Abergel A, Halimi C, Pauwels M, Bronowicki JP, Giostra E, Fleurot C, Gurnot D, Nouel O, Renard P, Rivoal M, Blanc P, Coumaros D, Ducloux S, Levy S, Pariente A, Perarnau JM, Roche J, Scribe-Outtas M, Valla D, Bernard B, Samuel D, Butel J, Hadengue A, Platek A, Lebrec D, Cadranel JF. Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter study. Gastroenterology. 2002 Apr;122(4):923-30.

ReferenceCitation: Halimi C, Bonnard P, Bernard B, Mathurin P, Mofredj A, di Martino V, Demontis R, Henry-Biabaud E, Fievet P, Opolon P, Poynard T, Cadranel JF. Effect of terlipressin (Glypressin) on hepatorenal syndrome in cirrhotic patients: results of a multicentre pilot study. Eur J Gastroenterol Hepatol. 2002 Feb;14(2):153-8.

ReferenceCitation: Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón JM, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J. Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome. J Hepatol. 2000 Jul;33(1):43-8.

ReferenceCitation: Mulkay JP, Louis H, Donckier V, Bourgeois N, Adler M, Deviere J, Le Moine O. Long-term terlipressin administration improves renal function in cirrhotic patients with type 1 hepatorenal syndrome: a pilot study. Acta Gastroenterol Belg. 2001 Jan-Mar;64(1):15-9.

ReferenceCitation: Singh V, Kumar B, Nain CK, Singh B, Sharma N, Bhalla A, Sharma AK. Noradrenaline and albumin in paracentesis-induced circulatory dysfunction in cirrhosis: a randomized pilot study. J Intern Med. 2006 Jul;260(1):62-8.

ReferenceCitation: Appenrodt B, Wolf A, Grünhage F, Trebicka J, Schepke M, Rabe C, Lammert F, Sauerbruch T, Heller J. Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study. Liver Int. 2008 Aug;28(7):1019-25. doi: 10.1111/j.1478-3231.2008.01734.x. Epub 2008 Apr 11.

ReferenceCitation: Sanyal AJ, Boyer T, Garcia-Tsao G, Regenstein F, Rossaro L, Appenrodt B, Blei A, Gülberg V, Sigal S, Teuber P; Terlipressin Study Group. A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome. Gastroenterology. 2008 May;134(5):1360-8. doi: 10.1053/j.gastro.2008.02.014. Epub 2008 Feb 13.

ReferenceCitation: Martín-Llahí M, Pépin MN, Guevara M, Díaz F, Torre A, Monescillo A, Soriano G, Terra C, Fábrega E, Arroyo V, Rodés J, Ginès P; TAHRS Investigators. Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study. Gastroenterology. 2008 May;134(5):1352-9. doi: 10.1053/j.gastro.2008.02.024. Epub 2008 Feb 14.

ReferenceCitation: Gadano A, Moreau R, Vachiery F, Soupison T, Yang S, Cailmail S, Sogni P, Hadengue A, Durand F, Valla D, Lebrec D. Natriuretic response to the combination of atrial natriuretic peptide and terlipressin in patients with cirrhosis and refractory ascites. J Hepatol. 1997 Jun;26(6):1229-34.

ReferenceCitation: Valla D, Lee SS, Moreau R, Hadengue A, Sayegh R, Lebrec D. [Effects of glypressin on the splanchnic and systemic circulation in patients with cirrhosis]. Gastroenterol Clin Biol. 1985 Dec;9(12):877-80. French.

ReferenceCitation: Arroyo V, Ginès P, Gerbes AL, Dudley FJ, Gentilini P, Laffi G, Reynolds TB, Ring-Larsen H, Schölmerich J. Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club. Hepatology. 1996 Jan;23(1):164-76. Review.