title: Impact of the Time of Oral Nutritional Supplements (ONS) Consumption on Daily Alimentary Intakes of Malnourished Elderly Subjects Hospitalized in Long Term Care Unit (LTCU)

acronym: ACTICLAN

summary: Malnutrition is a severe comorbidity in hospitalised patients, especially in elderly. The consumption of Oral Nutritional Supplements (NOS) is one of several tools for fighting against malnutrition. Their use is easy, and framed by recent French recommendations suggesting to propose NOS at end of meals or as snacking . Nevertheless, there is no scientific data to affirm which is the best of these two hypothesis in elderly hospitalised in Long Term Care Unit(LTCU) . Moreover, a preliminary survey of NOS consumption in LTCU in Limoges university hospital showed some problems about the mode of supplying NOS, partially linked with an insufficiency for paramedical staff in realizing importance of NOS. However, the effect of time of supplying NOS on total food consumption had not been evaluated in this first study. The new one will include 48 malnourished elderly patients in two LTCU and having a prescription of NOS. They will receive them at the same quantity during the whole study either firstly at end of meals (10 days) and secondly as snackings (10 days), or conversely. Order of choice will be randomised. Total daily alimentary intakes will be noted by paramedical staff of the two units, and translated by dieticians in daily energy, protein, carbohydrates and lipids intakes. The time of supplying NOS will be confronted with these intakes, in order to precise the best one.

lead_sponsor: University Hospital, Limoges

location_facility: Unité de Nutrition - Service hépato-gastro-entérologie


title: Predictive Value of FDG-TEP During Radiotherapy (RT) or Chemo-radiotherapy (CRT) in Patients With Non Small Cell Lung Cancer on the One-year Survival

summary:
The poor prognosis in the early-stage of lung cancer is due to potential worsening of the disease (local relapse, metastasis), to insufficient efficacy and toxicity of actual treatments.

FDG-PET is a medical imaging modality allowing the quantification of the tumour glucose consumption. Then, this exam is used for pathology staging, target volume definition for RT, and treatment efficiency few months after RT or CRT. Our assumption is that an FDG-PET exam during the course of the RT or CRT might be predictive of the treatment efficiency few months later.

In this study, the investigators propose to perform 4 FDG-PET: first "PET1" before radiotherapy, second "PET2" during the radiotherapy (see RTEP1), third and fourth "PET3" "PET4" 3month and 12 month after the therapy.

The investigators will investigate the performances of FDG-PET performed during the RT or CRT for the prediction of the one-year patient heath outcome. If the predictive value of TEP2 is confirmed, the investigators would be able to optimize the planning treatment during the course of the therapy.

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Non-Randomized

enrollment_type: Actual

ReferenceType: derived

ReferenceCitation: Ganem J, Thureau S, Gardin I, Modzelewski R, Hapdey S, Vera P. Delineation of lung cancer with FDG PET/CT during radiation therapy. Radiat Oncol. 2018 Nov 12;13(1):219. doi: 10.1186/s13014-018-1163-2.

family: Ganem

full_name: J. Ganem

given: J.

sequence: first

family: Thureau

full_name: S. Thureau

given: S.

sequence: additional

family: Gardin

full_name: I. Gardin

given: I.

family: Modzelewski

full_name: R. Modzelewski

given: R.

family: Hapdey

full_name: S. Hapdey

family: Vera

full_name: P. Vera

given: P.

bso_classification: Medical research

currency_apc_doaj: GBP

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Radiation Oncology

oa_colors: green gold

oa_host_type: publisher;repository

evidence: oa journal (via doaj)

host_type: publisher

license: cc-by

license_normalized: cc-by

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

license_normalized: no license

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer

ReferenceCitation: Calais J, Thureau S, Dubray B, Modzelewski R, Thiberville L, Gardin I, Vera P. Areas of high 18F-FDG uptake on preradiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for non-small cell lung cancer. J Nucl Med. 2015 Feb;56(2):196-203. doi: 10.2967/jnumed.114.144253. Epub 2015 Jan 8.

family: Calais

full_name: Jérémie Calais

given: Jérémie

full_name: Sébastien Thureau

given: Sébastien

family: Dubray

full_name: Bernard Dubray

given: Bernard

full_name: Romain Modzelewski

given: Romain

family: Thiberville

full_name: Luc Thiberville

given: Luc

full_name: Isabelle Gardin

given: Isabelle

full_name: Pierre Vera

given: Pierre

journal_name: Journal of Nuclear Medicine

oa_host_type: publisher

evidence: open (via free pdf)

publisher: Society of Nuclear Medicine

publisher_dissemination: Society of Nuclear Medicine

title: Areas of High 18F-FDG Uptake on Preradiotherapy PET/CT Identify Preferential Sites of Local Relapse After Chemoradiotherapy for Non–Small Cell Lung Cancer

ReferenceCitation: Vera P, Mezzani-Saillard S, Edet-Sanson A, Ménard JF, Modzelewski R, Thureau S, Meyer ME, Jalali K, Bardet S, Lerouge D, Houzard C, Mornex F, Olivier P, Faure G, Rousseau C, Mahé MA, Gomez P, Brenot-Rossi I, Salem N, Dubray B. FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a prospective multicentre study (RTEP2). Eur J Nucl Med Mol Imaging. 2014 Jun;41(6):1057-65. doi: 10.1007/s00259-014-2687-9. Epub 2014 Feb 22.

journal_name: European Journal of Nuclear Medicine and Molecular Imaging


title: Study of the Modification of the Fixation of FDG, F-Miso and FLT Measured in PET/CT at Patients Before and in the Course of Exclusive Radiotherapy or Concomitant Radiochemotherapy for Primitive Bronchial Cancer

summary:
Study of the modification of the fixation(binding) of Fluoro-2-deoxy-D-glucose (FDG), fluoro-misonidazole (FMISO) and 3'deoxy-3-fluoro-thymidine deoxy-3-fluoro-thymidine (FLT) measured in tomography by broadcast(emission,issue) of positrons (PET) at patients before and in the course of exclusive radiotherapy or concomitant radiochemotherapy for primitive bronchial cancer.

This protocle allows to study the simultaneous variations of the metabolism, the hypoxie and the cellular proliferation by PET SCAN at 5 patients reached(affected) by a primitive bronchial cancer in the course of exclusive radiotherapy for primitive bronchial cancer not small cell lung.

The investigators are also going to study several scenarii of optimization of the radiotherapy according to the variations of the tumoral metabolism, the hypoxie and the cellular proliferation measured in the course of radiotherapy (theoretical study on console using the scanner and the various examinations).

study_type: Observational

time_perspective: Prospective

title: Delineation of lung cancer with FDG PET/CT during radiation therapy


title: Prospective Randomized Study of Compression Stockings in Ankle Sprain in Adults

acronym: CASED

summary: This is a multicenter prospective randomized superiority controlled trial comparing leg stockings and standard care to standard care of ankle sprain and testing the hypothesis that compression stockings enable to reduce the median of recovery from ankle sprain by at least 6 days.

design_allocation: Randomized

primary_purpose: Treatment

ReferenceCitation: Bendahou M, Khiami F, Saïdi K, Blanchard C, Scepi M, Riou B, Besch S, Hausfater P. Compression stockings in ankle sprain: a multicenter randomized study. Am J Emerg Med. 2014 Sep;32(9):1005-10. doi: 10.1016/j.ajem.2014.05.054. Epub 2014 Jun 12.

family: Bendahou

full_name: Mouhssine Bendahou

given: Mouhssine

family: Khiami

full_name: Frédéric Khiami

given: Frédéric

family: Saïdi

full_name: Khaled Saïdi

given: Khaled

family: Blanchard

full_name: Cécile Blanchard

given: Cécile

family: Scepi

full_name: Michel Scepi

given: Michel

family: Riou

full_name: Bruno Riou

given: Bruno

family: Besch

full_name: Sylvie Besch

given: Sylvie

family: Hausfater

full_name: Pierre Hausfater

journal_name: The American Journal of Emergency Medicine

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

lead_sponsor: Assistance Publique - Hôpitaux de Paris

intervention_type: Other

lead_sponsor_type: academique

status_simplified: Completed


type: Other Identifier

title: Echocardiographic Assessment of Volume Variation Secondary to Preoperative Fasting

summary: The primary objective of this study is to demonstrate that preoperative fasting does not increase the rate of lowered blood volume (defined by a variation of 15% ΔITV during a leg lift) in patients undergoing surgery.

ReferenceCitation: Muller L, Brière M, Bastide S, Roger C, Zoric L, Seni G, de La Coussaye JE, Ripart J, Lefrant JY. Preoperative fasting does not affect haemodynamic status: a prospective, non-inferiority, echocardiography study. Br J Anaesth. 2014 May;112(5):835-41. doi: 10.1093/bja/aet478. Epub 2014 Feb 3.

family: Muller

full_name: L. Muller

given: L.

family: Brière

full_name: M. Brière

given: M.

family: Bastide

full_name: S. Bastide

given: S.

family: Roger

full_name: C. Roger

given: C.

family: Zoric

full_name: L. Zoric

family: Seni

full_name: G. Seni

given: G.

family: de La Coussaye

full_name: J.-E. de La Coussaye

family: Ripart

full_name: J. Ripart

given: J.

family: Lefrant

full_name: J.-Y. Lefrant

journal_name: British Journal of Anaesthesia

evidence: open (via crossref license)

license: elsevier-specific: oa user license

license_normalized: elsevier-specific

lead_sponsor: Centre Hospitalier Universitaire de Nīmes

location_facility: Centre Hospitalier Universitaire de Nîmes

intervention_type: Procedure


title: Observation of the Gait Cycle in Patients With Hemiplegia in Order to Improve the Triggering of Functional Electrical Stimulation

acronym: MASEA

summary: The main objective of this study is the estimation and comparison of the dephasing between the switch heel and the inertial placed on the paretic foot compared to the events of the gait cycle determined by a Gaitrite system (beginning and end of the swing phase) in conditions without stimulation.


title: Effects of an Individualized Training Program on Severity Markers of Obstructives Sleep Apnea/Hypopnea Syndrome (OSAS)

acronym: REEVASAS

summary: There are two types of treatments depending on the severity of Obstructive Sleep Apnea/Hypopnea Syndrome (OSAS): - for the treatment of severe (AHI> 30/h), the standard treatment is Continuous Positive Airway Pressure (CPAP). If it proved effective in reducing excessive daytime sleepiness and associated cardiovascular risk, compliance of patients 4 years of treatment falls below 70%. - Treatment of moderate (AHI between 15 and 30/h), lifestyle measures, the bracing of mandibular advancement and / or possibly the head and neck surgery can be proposed. These treatments include side effects and their effectiveness is very controversial.Il therefore seemed interesting to test the impact of physical activity through a standardized training program to re personal effort on the development and improvement of OSAS patients with a sedentary moderate to severe OSAS (AHI between 15 and 40 / h) The main assumption is that the ESR could eventually delay the initiation of treatment with CPAP in severe OSAS or an alternative therapeutic relevance in the moderate OSAS and severe in patients who can not tolerate conventional treatment(CSF). The main objective of this biomedical research is to evaluate the effects of a program of REE in ambulatory index of hourly apneas / hypopneas (AHI = marker of severity of OSAS) .- objectives specify 2AIR effects of REE on the quality of sleep (TxSLP) and daytime symptoms (EDS objective fatigue) on the one hand and the other on the metabolism (OV, SM, IR) and markers of LCR (inflammation, oxidative stress , endothelial function).

ReferenceCitation: Bughin F, Desplan M, Mestejanot C, Picot MC, Roubille F, Jaffuel D, Mercier J, Jaussent I, Dauvilliers Y. Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial. Sleep Med. 2020 Jun;70:33-42. doi: 10.1016/j.sleep.2020.02.008. Epub 2020 Feb 18.

family: Bughin

full_name: F. Bughin

given: F.

family: Desplan

full_name: M. Desplan

family: Mestejanot

full_name: C. Mestejanot

family: Picot

full_name: M.C. Picot

family: Roubille

full_name: F. Roubille

family: Jaffuel

full_name: D. Jaffuel

given: D.

family: Mercier

full_name: J. Mercier

family: Jaussent

full_name: I. Jaussent

given: I.

family: Dauvilliers

full_name: Y. Dauvilliers

given: Y.

journal_name: Sleep Medicine

oa_colors: green other

evidence: open (author manuscript)

version: acceptedVersion

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

repository_normalized: HAL

version: submittedVersion

lead_sponsor: University Hospital, Montpellier


title: Adaptation to Nocturnal Noninvasive Ventilation in Patients With Chronic Respiratory Failure

acronym: ROOMILA

summary:
BACKGROUND: Adaptation to noninvasive ventilation (NIV) is a critical step for acceptability and efficacy of this treatment during sleep in patients with chronic respiratory failure.

AIM: To study the variability of patient-ventilator interactions during the first nights after initiation to NIV. Recorded data will be analyzed in part by dedicated tools from the non-linear dynamics theory.

PATIENTS AND METHODS: Patients with chronic respiratory failure at stable state and indicated to home NIV will be included. All patients will perform three polysomnographies (under spontaneous breathing at D1 and under NIV at D2 and D15 after NIV initiation). All ventilatory physiological data (pressure, flow, patient-ventilator interactions, oxygen saturation, non intentional leaks) will be recorded during sleep under NIV in the Sleep Laboratory of the Department and secondarily related to sleep architecture and quality of sleep.

EXPECTED RESULTS: This study will identify objective parameters that are associated to a satisfactory adaptation to nocturnal NIV.

enrollment_type: Anticipated

lead_sponsor: Groupe de Recherche sur le Handicap Respiratoire

location_facility: Pulmonary & Respiratory Intensive Care Department - Rouen University Hospital

lead_sponsor_type: industriel


title: Evaluation of the Continuous Measurement of Tissular (StO2) and Cerebral (ScO2) Oxygenation During Lung Surgery and During the 6 First Postoperative Hours (Prospective Monocentric Study).

summary: The purpose of this study is to compare the ability of two peripheral and non invasive devices to detect hypoxic events during one-lung ventilation and during the early postoperative period. One device measures regional cerebral oxygenation and the other muscular oxygenation. These two devices are compared to non invasive arterial saturation (SpO2), which is the gold standard.

ReferenceType: background

ReferenceCitation: Manfredini F, Malagoni AM, Felisatti M, Mandini S, Mascoli F, Manfredini R, Basaglia N, Zamboni P. A dynamic objective evaluation of peripheral arterial disease by near-infrared spectroscopy. Eur J Vasc Endovasc Surg. 2009 Oct;38(4):441-8. doi: 10.1016/j.ejvs.2009.06.011. Epub 2009 Jul 21.

ReferenceCitation: Mesquida J, Masip J, Gili G, Artigas A, Baigorri F. Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients. Intensive Care Med. 2009 Jun;35(6):1106-9. doi: 10.1007/s00134-009-1410-y. Epub 2009 Jan 29.

ReferenceType: result

ReferenceCitation: Kazan R, Bracco D, Hemmerling TM. Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications. Br J Anaesth. 2009 Dec;103(6):811-6. doi: 10.1093/bja/aep309.

family: Kazan

full_name: R. Kazan

given: R.

family: Bracco

full_name: D. Bracco

family: Hemmerling

full_name: T.M. Hemmerling

ReferenceCitation: Hemmerling TM, Kazan R, Bracco D. Inter-hemispheric cerebral oxygen saturation differences during thoracic surgery in lateral head positioning. Br J Anaesth. 2009 Jan;102(1):141-2. doi: 10.1093/bja/aen336.

title: Inter-hemispheric cerebral oxygen saturation differences during thoracic surgery in lateral head positioning †

lead_sponsor: Hopital Foch

intervention_type: Device


title: Physiological Study on Glutamine and Leucine Effects on Intestinal Protein Metabolism

acronym: Intesmetapro

summary: Gut protein metabolism that could be influenced by protein supply is involved in the regulation of several physiological functions such as gut barrier function and represents a major contribution in the whole-body protein turnover. Intracellular pathways implicated in the transduction of amino acids effects remained unknown in the human gut. Thus, the aim of the present project is to evaluate and to understand the effects of amino acids (glutamine, leucine) on gut protein metabolism (synthesis and degradation) in young healthy humans.

ReferenceCitation: Goichon A, Bertrand J, Chan P, Lecleire S, Coquard A, Cailleux AF, Vaudry D, Déchelotte P, Coëffier M. Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa. Am J Clin Nutr. 2015 Aug;102(2):359-67. doi: 10.3945/ajcn.114.104216. Epub 2015 Jun 24.

family: Goichon

full_name: Alexis Goichon

given: Alexis

family: Bertrand

full_name: Julien Bertrand

given: Julien

family: Chan

full_name: Philippe Chan

given: Philippe

family: Lecleire

full_name: Stéphane Lecleire

given: Stéphane

family: Coquard

full_name: Aude Coquard

given: Aude

family: Cailleux

full_name: Anne-Françoise Cailleux

given: Anne-Françoise

family: Vaudry

full_name: David Vaudry

given: David

family: Déchelotte

full_name: Pierre Déchelotte

given: Pierre

family: Coëffier

full_name: Moïse Coëffier

given: Moïse

journal_name: The American Journal of Clinical Nutrition

oa_colors: green hybrid

license: implied-oa

license_normalized: implied-oa

publisher: Oxford University Press (OUP)

publisher_dissemination: Oxford University Press

publisher_group: Oxford University Press

publisher_normalized: Oxford University Press

ReferenceCitation: Bertrand J, Goichon A, Chan P, Azhar S, Lecleire S, Donnadieu N, Vaudry D, Cailleux AF, Déchelotte P, Coëffier M. Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa. Amino Acids. 2014 Apr;46(4):1059-67. doi: 10.1007/s00726-014-1670-x. Epub 2014 Jan 22.

family: Azhar

full_name: Saida Azhar

given: Saida

family: Donnadieu

full_name: Nathalie Donnadieu

given: Nathalie

ReferenceCitation: Coëffier M, Claeyssens S, Bôle-Feysot C, Guérin C, Maurer B, Lecleire S, Lavoinne A, Donnadieu N, Cailleux AF, Déchelotte P. Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of rapamycin-independent pathway. Am J Clin Nutr. 2013 Feb;97(2):286-94. doi: 10.3945/ajcn.112.046946. Epub 2013 Jan 2.

title: Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of rapamycin–independent pathway

ReferenceCitation: Coëffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, Donnadieu N, Lavoinne A, Cailleux AF, Déchelotte P. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3. Am J Clin Nutr. 2011 Jun;93(6):1255-62. doi: 10.3945/ajcn.111.013649. Epub 2011 Apr 20.

location_facility: Centre d'Investigation Clinique - Hôpital charles Nicolle


title: Paradoxical Reactions During Anti-mycobacterial Treatment of Extrapulmonary Tuberculosis in Non Immuno-compromized Patients : Clinical, Radiological et Immunological

acronym: PARATB

summary: Tuberculous paradoxical reactions (PR) are immune reactions occurring during the course of antituberculous treatment and leading to a worsening of tuberculous symptoms after an initial improvement. This phenomenon has very extensively studied in HIV infected patients where it corresponds to the so called IRIS (immune reconstitution syndrome). However, it laso occurs in non immuno-compromized patients, especially those with extra-pulmonary localization of tuberculosis. The aim of the study is to look for risk factors of paradoxical reaction in non immuno-compromized patients with extra-pulmonary tuberculosis. The investigators will consider clinical, radiological and biological variables, including specific immune and genetic markers. Our secondary goals are to estimate the incidence of PR, describe their natural history; characterize the type of immune response they correspond to, and look for better diagnostic tools.The immunological characterization and the finding of predictive factors of PR, especially the genetic ones will allow a better understanding of biological mechanisms that lead to their occurrence during extra-pulmonary tuberculosis treatment. The establishment of predictive criteria could permit a better surveillance of at risk patients for a rapid treatment, or even a prevention of PR. The establishment of new diagnostic criteria at the time of PR could avoid numerous invasive diagnostic procedures, surgery and/or useless prolongation of antibiotic treatment.

study_start_date_type: Actual


title: French Observatory Syndromes Tako-Tsubo

acronym: OFSETT

summary: Tako Tsubo syndrome (TTS) is characterized by the occurrence in the context of mental or physical stress, a clinical and ECG of acute myocardial infarction without significant coronary artery stenosis, accompanied by a disorder Acute, reversible left ventricular who takes on a characteristic apical ballonnisation evoking the image of a Japanese octopus trap called Tako (octopus) tsubo (jar). Pathophysiology of unknown changes immediate life-threatening prognosis is often good in the longer term.

time_perspective: Cross-Sectional

ReferenceCitation: Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Kono Y, Umemura T, Nakamura S. Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J. 2002 Mar;143(3):448-55.

ReferenceCitation: Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, Yoshiyama M, Miyazaki S, Haze K, Ogawa H, Honda T, Hase M, Kai R, Morii I; Angina Pectoris-Myocardial Infarction Investigations in Japan. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J Am Coll Cardiol. 2001 Jul;38(1):11-8.

ReferenceCitation: Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation. 2005 Feb 1;111(4):472-9.

ReferenceCitation: Parodi G, Del Pace S, Carrabba N, Salvadori C, Memisha G, Simonetti I, Antoniucci D, Gensini GF. Incidence, clinical findings, and outcome of women with left ventricular apical ballooning syndrome. Am J Cardiol. 2007 Jan 15;99(2):182-5. Epub 2006 Nov 14.

ReferenceCitation: Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J. 2006 Jul;27(13):1523-9. Epub 2006 May 23. Review.

ReferenceCitation: El Mahmoud R, Mansencal N, Pilliére R, Leyer F, Abbou N, Michaud P, Nallet O, Digne F, Lacombe P, Cattan S, Dubourg O. Prevalence and characteristics of left ventricular outflow tract obstruction in Tako-Tsubo syndrome. Am Heart J. 2008 Sep;156(3):543-8. doi: 10.1016/j.ahj.2008.05.002. Epub 2008 Jul 7.

ReferenceCitation: Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, Thiele H. Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging. Eur Heart J. 2008 Nov;29(21):2651-9. doi: 10.1093/eurheartj/ehn433. Epub 2008 Sep 27.

ReferenceCitation: Yayehd K, N'da NW, Belle L, Bataille V, Hanssen M, Leddet P, Aupetit JF, Commeau P, Filippi E, Georges JL, Albert F, Rangé G, Meimoun P, Marcaggi X, Baleynaud S, Nallet O, Dibie A, Barnay C, Jouve B, Legrand M, Cattan S, Mulak G, Simon T, Danchin N, Dujardin JJ; OFSETT investigators. Management of Takotsubo cardiomyopathy in non-academic hospitals in France: The Observational French SyndromEs of TakoTsubo (OFSETT) study. Arch Cardiovasc Dis. 2016 Jan;109(1):4-12. doi: 10.1016/j.acvd.2015.08.004. Epub 2015 Oct 23.

family: Yayehd

full_name: Komlavi Yayehd

given: Komlavi

family: N’da

full_name: N’kenon W. N’da

given: N’kenon W.

family: Belle

full_name: Loïc Belle

given: Loïc

family: Bataille

full_name: Vincent Bataille

given: Vincent

family: Hanssen

full_name: Michel Hanssen

given: Michel

family: Leddet

full_name: Pierre Leddet

family: Aupetit

full_name: Jean-François Aupetit

given: Jean-François

family: Commeau

full_name: Philippe Commeau

family: Filippi

full_name: Emmanuelle Filippi

given: Emmanuelle

family: Georges

full_name: Jean-Louis Georges

given: Jean-Louis

family: Albert

full_name: Franck Albert

given: Franck

family: Rangé

full_name: Grégoire Rangé

given: Grégoire

family: Meimoun

full_name: Patrick Meimoun

given: Patrick

family: Marcaggi

full_name: Xavier Marcaggi

given: Xavier

family: Baleynaud

full_name: Serge Baleynaud

given: Serge

family: Nallet

full_name: Olivier Nallet

given: Olivier

family: Dibie

full_name: Alain Dibie

given: Alain

family: Barnay

full_name: Claude Barnay

given: Claude

family: Jouve

full_name: Bernard Jouve

given: Bernard

family: Legrand

full_name: Maud Legrand

given: Maud

family: Cattan

full_name: Simon Cattan

given: Simon

family: Mulak


title: Stent For Life Observatory

acronym: SFL

summary: Observatory multicenter, prospective, to support the acute phase of acute coronary syndromes with ST segment elevation ST (myocardial infarction).

ReferenceCitation: Cambou JP, Simon T, Mulak G, Bataille V, Danchin N. The French registry of Acute ST elevation or non-ST-elevation Myocardial Infarction (FAST-MI): study design and baseline characteristics. Arch Mal Coeur Vaiss. 2007 Jun-Jul;100(6-7):524-34.

ReferenceCitation: Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Méneveau N, Steg PG, Ferrières J, Danchin N, Becquemont L; French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009 Jan 22;360(4):363-75. doi: 10.1056/NEJMoa0808227. Epub 2008 Dec 22.

family: Simon

full_name: Tabassome Simon

given: Tabassome

family: Verstuyft

full_name: Céline Verstuyft

given: Céline

family: Mary-Krause

full_name: Murielle Mary-Krause

given: Murielle

family: Quteineh

full_name: Lina Quteineh

given: Lina

family: Drouet

full_name: Elodie Drouet

given: Elodie

family: Méneveau

full_name: Nicolas Méneveau

given: Nicolas

family: Steg

full_name: P. Gabriel Steg

given: P. Gabriel

family: Ferrières

full_name: Jean Ferrières

given: Jean

family: Danchin

full_name: Nicolas Danchin

family: Becquemont

full_name: Laurent Becquemont

given: Laurent

journal_name: New England Journal of Medicine

publisher: Massachusetts Medical Society

publisher_dissemination: Massachusetts Medical Society

publisher_group: Massachusetts Medical Society

publisher_normalized: Massachusetts Medical Society

title: Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

lead_sponsor: French Cardiology Society


title: Study on the Appropriateness of Bariatric Surgery in Adolescents

summary: single-center study carried out in order to evaluate in prospective among patients seen or treated in the pediatric endocrinology unit and multidisciplinary management of obesity, the potential number of patients eligible for surgery.

status: Terminated

lead_sponsor: University Hospital, Toulouse

status_simplified: Unknown


title: Has the Quota of Signet Ring Cells an Influence on Prognosis and Treatment Strategy in the Upper GI Tract Adenocarcinomas?

summary:
Background • A major increase in incidence of signet ring cell adenocarcinomas (ADCI) of the upper digestive tract in western countries

Discordant results in the literature concerning the prognosis value of the presence of signet ring cells.
Preliminary data suggesting (i) an advanced stage at time of diagnosis, (ii) more often in the form of carcinose, (iii) a more pejorative prognosis, (iv) a recurrence more frequent, more quickly, and more often in the form of peritoneal carcinose, (v) a chemo resistance (vi) the need for a specific therapeutic strategy compared to non-signet ring cell adenocarcinomas.

Primary objective To test the hypothesis that 5-year survival rate is significantly lower in the signet ring cells (SRC) adenocarcinoma when compared to non-SRC adenocarcinoma in the upper digestive tract

Secondary objectives

Impact of neoadjuvant CT on overall survival
Impact and differential diagnostic value of linitis
R0 resection rates
3 years recurrence free survival
Overall 3 years survival
Prognostic factors
Prognostic value of the presence of a minority quota of signet ring cell
Objective response rate after medical treatment (chemotherapy, radiochemotherapy) in non-resected patients
Tolerance of (radio) chemotherapy for ADCI

Methodology Intention to treat retrospective case-control multicentric study A pairing on demographic criteria (age, sex, ASA score, center) and tumor criteria (TNM stage) will be done to ensure comparability in case control study groups.

Inclusion criteria All consecutive patients taken care of, for a proven histologically adenocarcinoma (ADCI and ADNCI) of the esophagus, the esogastric junction, or the stomach, in surgical or medical oncology investigator centers, will be saved in a given database.

For whom the first consultation took place between January 1997 and January 2010

Exclusion criteria Histological type other than adenocarcinoma Other localization than esogastric junction, esophagus or stomach

Planned study period The data will be collected over a period from January 1997 to January 2010.

The objective is to complete the data collection for summer 2010.

time_perspective: Retrospective

ReferenceCitation: Robb WB, Messager M, Goere D, Pichot-Delahaye V, Lefevre JH, Louis D, Guiramand J, Kraft K, Mariette C; FREGATWorking Group-FRENCH. Predictive factors of postoperative mortality after junctional and gastric adenocarcinoma resection. JAMA Surg. 2013 Jul;148(7):624-31. doi: 10.1001/jamasurg.2013.63.

family: Robb

full_name: William B. Robb

given: William B.

journal_name: JAMA Surgery

publisher: American Medical Association (AMA)

publisher_dissemination: American Medical Association

publisher_group: American Medical Association

publisher_normalized: American Medical Association

title: Predictive Factors of Postoperative Mortality After Junctional and Gastric Adenocarcinoma Resection

ReferenceCitation: Messager M, Lefevre JH, Pichot-Delahaye V, Souadka A, Piessen G, Mariette C; FREGAT working group - FRENCH. The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. Ann Surg. 2011 Nov;254(5):684-93; discussion 693. doi: 10.1097/SLA.0b013e3182352647.

family: Messager

full_name: Mathieu Messager

given: Mathieu

family: Lefevre

full_name: Jérémie H. Lefevre

given: Jérémie H.

family: Pichot-Delahaye

full_name: Virginie Pichot-Delahaye

given: Virginie

family: Souadka

full_name: Amine Souadka

given: Amine

family: Piessen

full_name: Guillaume Piessen

given: Guillaume

family: Mariette

full_name: Christophe Mariette

given: Christophe

family: Arnaud

full_name: Jean Pierre Arnaud

given: Jean Pierre

family: Balon

full_name: Jean Michel Balon

given: Jean Michel

family: Bonnetain

full_name: Frank Bonnetain

given: Frank

family: Borie

full_name: Frédéric Borie

given: Frédéric

family: Brachet

full_name: Dorothée Brachet

given: Dorothée

family: Brigand

full_name: Cécile Brigand

given: Cécile

family: Carrere

full_name: Nicolas Carrere

family: D'Journo

full_name: Xavier Benoit D'Journo

given: Xavier Benoit

family: Dechelotte

full_name: Pierre Dechelotte

given: Pierre

family: Delpero

full_name: Jean Robert Delpero

given: Jean Robert

family: Dhari

full_name: Abdenaceur Dhari

given: Abdenaceur

family: Fabre

full_name: Sylvain Fabre

given: Sylvain

family: Fernandez

full_name: Manuel Fernandez

given: Manuel

publisher: Ovid Technologies (Wolters Kluwer Health)

title: The Impact of Perioperative Chemotherapy on Survival in Patients With Gastric Signet Ring Cell Adenocarcinoma


title: Impact of Raltegravir on the Viral Reservoirs

summary:
The objective of the antiretroviral treatment is to inhibit the viral replication, estimated(appreciated) by the measure of the viral plasmatic load(responsibility). In this inhibition of the viral replication usually joins an immune reconstruction [ 1 ]. Nevertheless, a viro-immunological dissociation, i.e. an undetectable viral load(responsibility) and an absence of immune reconstruction, is regularly observed. It is now turned out that an undetectable viral load(responsibility) does not correspond to the total absence of viral replication and that it is possible to detect of the intracellular pro-viral DNA . Raltegravir ®, because of its mode of action(share) inhibiting the integration of the pro-viral DNA in the chromosomes of the infected cells(units) , could decrease the intracellular reservoir of monocyte-macrophages, improve the homeostasis, so optimizing the cooperation lymphocytes T - macrophages. Several experimental data suggest that the regression of the abnormalities of cellular interactions, and the rate of apoptose abnormally raised(abnormally brought up) by cells(units) T at the patients in viro-immunological dissociation, could be obtained .

This study aims at measuring the impact of Raltegravir ® on the viral reservoirs lymphocyte and monocyte, to quantify the expression of the molecules of costimulation, the source(spring) of intercellular interactions lymphocytes - monocytes, and to measure the rate of apoptose of the cells(units) T.

status: Unknown status

study_completion_date_type: Anticipated

lead_sponsor: Centre Hospitalier Universitaire de Nice


title: Metabolic Impact of the Digestion of Fat in Emulsified vs Non-emulsified Form in Lean or Obese Volunteers

acronym: LIPINFLOX

summary:
In this study, the investigators are interested in investigating how the emulsification state and amount of fat in a meal can modify the kinetics of postprandial lipemia and inflammatory outcomes (including endotoxemia) in obese vs lean subjects.

10 lean and 10 obese volunteers will come 3 times (>3 weeks apart) at the investigation center to receive a standard breakfast containing milk fat (10 g non emulsified, or 40 g non emulsified, or 40 g finely emulsified). 13C triglyceride stable isotopes will allow to follow the metabolic fate of fatty acids and calculate lipid oxidation by breath test. Blood sampling throughout digestion will allow to measure metabolic, lipid and inflammation parameters. Stool will be analysed to determine lipid losses in faeces and to phenotype microbiota.

primary_purpose: Basic Science

ReferenceCitation: Vors C, Drai J, Pineau G, Laville M, Vidal H, Laugerette F, Michalski MC. Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study. Lipids Health Dis. 2017 May 25;16(1):97. doi: 10.1186/s12944-017-0486-6.

family: Vors

full_name: Cécile Vors

family: Drai

full_name: Jocelyne Drai

given: Jocelyne

family: Pineau

full_name: Gaëlle Pineau

given: Gaëlle

family: Laville

full_name: Martine Laville

given: Martine

family: Vidal

full_name: Hubert Vidal

given: Hubert

family: Laugerette

full_name: Fabienne Laugerette

given: Fabienne

family: Michalski

full_name: Marie-Caroline Michalski

given: Marie-Caroline

journal_name: Lipids in Health and Disease

license: cc-by-sa

license_normalized: cc-by-sa

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Hospices Civils de Lyon

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Institut Pasteur

repositories:
HAL
PubMed Central

ReferenceCitation: Vors C, Pineau G, Drai J, Meugnier E, Pesenti S, Laville M, Laugerette F, Malpuech-Brugère C, Vidal H, Michalski MC. Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. J Clin Endocrinol Metab. 2015 Sep;100(9):3427-35. doi: 10.1210/JC.2015-2518. Epub 2015 Jul 7.

family: Meugnier

full_name: Emmanuelle Meugnier

given: Emmanuelle

family: Pesenti

full_name: Sandra Pesenti

given: Sandra

journal_name: The Journal of Clinical Endocrinology & Metabolism

ReferenceCitation: Vors C, Drai J, Gabert L, Pineau G, Laville M, Vidal H, Guichard E, Michalski MC, Feron G. Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? Int J Obes (Lond). 2015 Sep;39(9):1425-8. doi: 10.1038/ijo.2015.71. Epub 2015 Apr 28.

ReferenceCitation: Vors C, Pineau G, Gabert L, Drai J, Louche-Pélissier C, Defoort C, Lairon D, Désage M, Danthine S, Lambert-Porcheron S, Vidal H, Laville M, Michalski MC. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr. 2013 Jan;97(1):23-36. doi: 10.3945/ajcn.112.043976. Epub 2012 Dec 12.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

location_facility: Hospices Civils de Lyon,Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA)


type: Registry Identifier

title: Protein Need and Interest of " Quick Proteins " to the Obese Subject Operated by Bariatric Surgery (BIBOP)

acronym: BIBOP

summary: The main objective of the study is to evaluate the protein requirement associated with postoperative weight loss caused by by-pass (shunt which leads to a certain degree of malabsorption) or sleeve gastrectomy (more technically conservative with less malabsorption), through the study of nitrogen balance. The benefit of protein supply easily absorbed and with high essential amino acids content (proteins "fast" soluble milk) on protein metabolism and muscle function will also be studied. Endotoxemia and intestinal flora variations were measured before and after bariatric surgery.

primary_purpose: Other

ReferenceCitation: Guillet C, Masgrau A, Mishellany-Dutour A, Blot A, Caille A, Lyon N, Pereira B, Slim K, Robert M, Disse E, Feugier N, Le Ruyet P, Louvet C, Miolanne M, Farigon N, Laville M, Boirie Y. Bariatric surgery affects obesity-related protein requirements. Clin Nutr ESPEN. 2020 Dec;40:392-400. doi: 10.1016/j.clnesp.2020.06.007. Epub 2020 Oct 1.

family: Guillet

full_name: C. Guillet

given: C.

family: Masgrau

full_name: A. Masgrau

given: A.

family: Mishellany-Dutour

full_name: A. Mishellany-Dutour

family: Blot

full_name: A. Blot

family: Caille

full_name: A. Caille

family: Lyon

full_name: N. Lyon

given: N.

family: Pereira

full_name: B. Pereira

given: B.

family: Slim

full_name: K. Slim

given: K.

family: Robert

full_name: M. Robert

given: M.

family: Disse

full_name: E. Disse

given: E.

family: Feugier

full_name: N. Feugier

family: Le Ruyet

full_name: P. Le Ruyet

given: P.

family: Louvet

full_name: C. Louvet

family: Miolanne

full_name: M. Miolanne

family: Farigon

full_name: N. Farigon

full_name: M. Laville

family: Boirie

full_name: Y. Boirie

given: Y.

journal_name: Clinical Nutrition ESPEN

evidence: open (via crossref license, author manuscript)

lead_sponsor: University Hospital, Clermont-Ferrand


title: A Prospective Clinical Study of a Cohort of Pathological Patients Seeking Treatment for a Behavioral Addiction in the University Hospital of Nantes

acronym: EVALADD

summary: This research aims to provide a better understanding of the factors associated with the evolution of behavioral addictions, and compliance with care. The investigators thus aim to follow patients with several types of behavioral addictions, based on addictive, sociodemographic, clinical and endophenotypical characteristics, as well as their care adhesion.

status: Recruiting

time_perspective: Other

lead_sponsor: Nantes University Hospital

status_simplified: Ongoing


summary: The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.


primary_purpose: Health Services Research


title: Study of the Cutaneous Microcirculation: ASIC Involvement.

summary:
Pressure ulcers are a common and costly problem. Advancing the understanding regarding the basic pathophysiological mechanisms mediating the development of pressure ulcers will allow for better delineation of populations at risk.

Healthy skin is protected from pressure-induced ischemic damage because of the presence of pressure-induced vasodilation (PIV). In contrast, in absence of PIV, such as in diabetic patients or older subjects with sensory neuropathy, the skin is exposed to severe cutaneous ischemia, which could lead to pressure ulcer formation.

Since Acid Sensing Ion channels (ASICs) appear to be involved in the cutaneous mechanosensitivity, the investigators hypothesized that PIV could be altered by treatments that block ASICs.

ReferenceCitation: Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M. Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers. Nat Med. 2012 Aug;18(8):1205-7. doi: 10.1038/nm.2844. Epub 2012 Jul 29.

family: Fromy

full_name: Bérengère Fromy

given: Bérengère

family: Lingueglia

full_name: Eric Lingueglia

given: Eric

family: Sigaudo-Roussel

full_name: Dominique Sigaudo-Roussel

given: Dominique

family: Saumet

full_name: Jean Louis Saumet

given: Jean Louis

family: Lazdunski

full_name: Michel Lazdunski

given: Michel

journal_name: Nature Medicine

publisher_dissemination: Springer

publisher_group: Springer

lead_sponsor: Hospices Civils de Lyon

location_facility: Pôle d'activité medicale-Centre Hospitalier Lyon Sud-Hospices Civils de Lyon

intervention_type: Drug


title: Pilot Study of Lapatinib (Tyverb®) in Neoadjuvant Treatment for Patients With Locally Bladder Carcinoma Before Cystectomy

acronym: LAPAINBLAD

summary: Modification of the EGF signalling pathway and / or HER 2, by Lapatinib in bladder cancer.

ReferenceCitation: Rödel C, Weiss C, Sauer R. Trimodality treatment and selective organ preservation for bladder cancer. J Clin Oncol. 2006 Dec 10;24(35):5536-44. Review.

ReferenceCitation: Jimenez RE, Hussain M, Bianco FJ Jr, Vaishampayan U, Tabazcka P, Sakr WA, Pontes JE, Wood DP Jr, Grignon DJ. Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors. Clin Cancer Res. 2001 Aug;7(8):2440-7.

ReferenceCitation: Advanced Bladder Cancer (ABC) Meta-analysis Collaboration. Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 2005 Aug;48(2):202-5; discussion 205-6. Epub 2005 Apr 21.

lead_sponsor: University Hospital, Bordeaux

location_facility: CHU Bordeaux - Hôpital Saint André - Department of Medical Oncology


ReferenceCitation: Tauber M, Jaquet D, Jesuran-Perelroizen M, Petrus M, Bertrand AM, Coutant R; NordiFlex® French Study Group. User assessment of Norditropin NordiFlex(®), a new prefilled growth hormone pen: a Phase IV multicenter prospective study. Patient Prefer Adherence. 2013 May 24;7:455-62. doi: 10.2147/PPA.S43460. Print 2013. Erratum in: Patient Prefer Adherence. 2013 Aug 19;7:803.

family: Tauber

full_name: Tauber

family: Jaquet

full_name: Jaquet

family: Perelroizen

full_name: Perelroizen

family: Petrus

full_name: Petrus

family: Bertrand

full_name: Bertrand

family: Coutant

full_name: Coutant

currency_apc_doaj: USD

journal_name: Patient Preference and Adherence

evidence: open (via page says license)

license: cc-by-nc

license_normalized: cc-by-nc

publisher: Informa UK Limited

publisher_dissemination: Informa

publisher_group: Informa

publisher_normalized: Informa

title: User assessment of Norditropin NordiFlex®,a new prefilled growth hormone pen:a Phase IV multicenter prospective study

lead_sponsor: Novo Nordisk A/S

type: EudraCT Number

source: euctr

title: Assessment of the Ease of Use of Norditropin NordiFlex® Relative to the One of the Device Previously Used by Patients or Parents

summary: This study is conducted in Europe. The aim of this study is to compare the easiness of use of Norditropin NordiFlex® device to the device previously used by patients or parents.


title: Evaluation of Oxygen Therapy Delivery Systems in Hypoxemic Acute Respiratory Failure

acronym: OPTI O2

summary: The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent patients will compare the successive use of oxygen therapy delivery systems Optiflow®/Ospal® and 12 immunodeficient patients will compare the successive use of systems Optiflow®/Non invasive ventilation.


title: Étude Comparative, randomisée, Double-insu, en Groupes parallèles évaluant l'efficacité d'Eductyl® Versus Placebo Chez Des Patients Souffrant d'Une dyschésie

acronym: EDUCDYS

summary: The purpose of this study is to assess the efficacy of Eductyl versus placebo for treatment of patients with dyschesia.

lead_sponsor: Laboratoires Techni Pharma

location_facility: Hôpital Foch, Service de Chirurgie Générale et Digestive


title: Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome

acronym: RESPIRONDINE

summary:
The congenital central hypoventilation syndrome (CCHS), also known as the Ondine syndrome, is a very rare genetic disorder. In contrast with healthy people, patients do not increase breathing in response to an excess of carbon dioxide (CO2). As a consequence, they do not breath sufficiently, or even stop breathing, during sleep. Their survival depends only on mechanical respiratory assistance, all life long.

We have recently published two cases of recovery of a response to CO2 in patients taking desogestrel as a contraceptive pill. The goal of the study is therefore to assess the hypothesis that desogestrel will restore a respiratory response to CO2 in CCHS patients and allow them to breath sufficiently during sleep without mechanical assistance.

ReferenceCitation: Sharman M, Gallea C, Lehongre K, Galanaud D, Nicolas N, Similowski T, Cohen L, Straus C, Naccache L. The cerebral cost of breathing: an FMRI case-study in congenital central hypoventilation syndrome. PLoS One. 2014 Sep 30;9(9):e107850. doi: 10.1371/journal.pone.0107850. eCollection 2014.

family: Sharman

full_name: Mike Sharman

given: Mike

family: Gallea

full_name: Cécile Gallea

given: Cécile

family: Lehongre

full_name: Katia Lehongre

given: Katia

family: Galanaud

full_name: Damien Galanaud

given: Damien

family: Nicolas

full_name: Nathalie Nicolas

given: Nathalie

family: Similowski

full_name: Thomas Similowski

given: Thomas

family: Cohen

full_name: Laurent Cohen

given: Laurent

family: Straus

full_name: Christian Straus

given: Christian

family: Naccache

full_name: Lionel Naccache

given: Lionel

journal_name: PLoS ONE

evidence: oa repository (semantic scholar lookup)

publisher: Public Library of Science (PLoS)

publisher_dissemination: Public Library of Science

publisher_group: Public Library of Science

publisher_normalized: Public Library of Science

title: The Cerebral Cost of Breathing: An fMRI Case-Study in Congenital Central Hypoventilation Syndrome

ReferenceCitation: Straus C, Similowski T. Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to "C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel" [Respir. Physiol. Neurobiol. 171 (2010) 171-174]. Respir Physiol Neurobiol. 2011 Sep 15;178(2):357-8. doi: 10.1016/j.resp.2011.07.007. Epub 2011 Jul 23. Review.

journal_name: Respiratory Physiology & Neurobiology

title: Congenital central hypoventilation syndrome and desogestrel: A call for caution


title: Phase II Trial of Temozolomide in Elderly Patients With Glioblastoma and Poor Performance Status (KPS<70).

acronym: TAG

summary: The management of glioblastoma in elderly patients with poor performance status (KPS<70) is unsettled. This single arm phase 2 trial trial was designed to evaluate the efficacy and safety of temozolomide alone in this population


title: Effect of Bosentan in the Course of Scleroderma Renal Crisis

acronym: ScS-REINBO

summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by excessive collagen deposition, autoimmunity and by vascular hyper-reactivity and obliterative microvascular phenomena that involves multiple organs. Scleroderma Renal Crisis (SRC) occurs in 5% of patients and mainly with diffuse cutaneous SSc. The routine use of angiotensin-converting enzyme inhibitors (ACEI) has been reported to dramatically improve outcome, with a fall of the 12-month mortality from 76% to less than 15% in the United-States. Despite prognostic improvement, SRC remains a severe manifestation of SSc and functional outcome and survival remains poor. Bosentan is a specific, orally active, dual endothelin receptor antagonist that has recently been approved for the treatment of primary pulmonary arterial hypertension and for the prevention of ischemic digital ulcers. Bosentan could have therapeutic benefits on others vascular injuries and particularly in SRC.

location_facility: Pôle de médecine interne Centre de référence Maladies rares Groupe I Maladies systémiques et maladies auto-immunes rares en particulier Vascularites nécrosantes et les sclérodermies - Hôpital Cochin


title: Prognosis Value of Transient Elastography and Non-invasive Markers of Fibrosis in Patients With Chronic Liver Disease. A Prospective Follow-up of 4,935 Person-years

acronym: PVTE

summary: The aim of this prospective study was to compare the 5-year prognostic value of transient elastography (TE), FibroTest (FT), APRI , FIB-4, Lok, and Child-Pugh scores for predicting survival and complications of cirrhosis in patients with chronic liver diseases.

ReferenceCitation: Vergniol J, Boursier J, Coutzac C, Bertrais S, Foucher J, Angel C, Chermak F, Hubert IF, Merrouche W, Oberti F, de Lédinghen V, Calès P. Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C. Hepatology. 2014 Jul;60(1):65-76. doi: 10.1002/hep.27069.

name: Centre d'Investigation de la Fibrose hépatique, Hôpital Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux; Pessac France

family: Vergniol

full_name: Julien Vergniol

given: Julien

name: Service d'Hépato-Gastroentérologie, Centre Hospitalier Universitaire d'Angers; Angers France

name: Laboratoire HIFIH, UPRES 3859, SFR 4208, Université LUNAM; Angers France

family: Boursier

full_name: Jérôme Boursier

given: Jérôme

family: Coutzac

full_name: Clélia Coutzac

given: Clélia

family: Bertrais

full_name: Sandrine Bertrais

given: Sandrine

family: Foucher

full_name: Juliette Foucher

given: Juliette

family: Angel

full_name: Camille Angel

given: Camille

family: Chermak

full_name: Faiza Chermak

given: Faiza

family: Hubert

full_name: Isabelle Fouchard Hubert

given: Isabelle Fouchard

family: Merrouche

full_name: Wassil Merrouche

given: Wassil

family: Oberti

full_name: Frédéric Oberti

given: Frédéric

name: INSERM U1053, Université Segalen; Bordeaux France

family: de Lédinghen

full_name: Victor de Lédinghen

given: Victor

family: Calès

full_name: Paul Calès

given: Paul

journal_name: Hepatology

oa_host_type: repository

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

ReferenceCitation: Vergniol J, Foucher J, Terrebonne E, Bernard PH, le Bail B, Merrouche W, Couzigou P, de Ledinghen V. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology. 2011 Jun;140(7):1970-9, 1979.e1-3. doi: 10.1053/j.gastro.2011.02.058. Epub 2011 Mar 2.

family: Terrebonne

full_name: Eric Terrebonne

family: Bernard

full_name: Pierre–Henri Bernard

given: Pierre–Henri

family: le Bail

full_name: Brigitte le Bail

given: Brigitte

family: Couzigou

full_name: Patrice Couzigou

given: Patrice

family: de Ledinghen

title: Noninvasive Tests for Fibrosis and Liver Stiffness Predict 5-Year Outcomes of Patients With Chronic Hepatitis C

location_facility: Centre d'Investigation de la Fibrose hépatique Service Hepato-Gastroentérologie Hopital Haut-Leveque


title: Effect of Whole Grain Inclusion in the Diet on Abdominal Fat Regain After a Weight Loss Diet

summary:
Epidemiological studies suggest that whole grain consumption affects measures of obesity including BMI, body fat tissue, and body weight. Most cross-sectional studies demonstrate rather consistently an inverse association between BMI and whole grain consumption. Furthermore, prospective cohort studies suggest that people with high whole grain consumption have less risk for body weight gain compared with low whole grain consumption.

The purpose of this study is to assess the effects of inclusion of whole grain in the diet on anthropometric measures, particularly abdominal fat regain after a weight loss diet.

It is anticipated that the short-term regain of abdominal fat after a weight loss diet is lower in volunteers consuming whole grain than in volunteers consuming refined grain.

lead_sponsor: Cereal Partners Worldwide


title: The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction

summary: After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

ReferenceCitation: Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy-Cudraz E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012 Jun 12;59(24):2175-81. doi: 10.1016/j.jacc.2012.03.026.

family: Thuny

full_name: Franck Thuny

given: Franck

family: Lairez

full_name: Olivier Lairez

given: Olivier

family: Roubille

full_name: François Roubille

given: François

family: Mewton

full_name: Nathan Mewton

given: Nathan

family: Rioufol

full_name: Gilles Rioufol

given: Gilles

family: Sportouch

full_name: Catherine Sportouch

given: Catherine

family: Sanchez

full_name: Ingrid Sanchez

given: Ingrid

family: Bergerot

full_name: Cyrille Bergerot

given: Cyrille

family: Thibault

full_name: Hélène Thibault

given: Hélène

family: Cung

full_name: Thien Tri Cung

given: Thien Tri

family: Finet

full_name: Gérard Finet

given: Gérard

family: Argaud

full_name: Laurent Argaud

given: Laurent

family: Revel

full_name: Didier Revel

given: Didier

family: Derumeaux

full_name: Geneviève Derumeaux

given: Geneviève

family: Bonnefoy-Cudraz

full_name: Eric Bonnefoy-Cudraz

given: Eric

family: Elbaz

full_name: Meier Elbaz

given: Meier

family: Piot

full_name: Christophe Piot

given: Christophe

family: Ovize

full_name: Michel Ovize

given: Michel

family: Croisille

full_name: Pierre Croisille

given: Pierre

journal_name: Journal of the American College of Cardiology

title: Post-Conditioning Reduces Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial Infarction


title: Early Lung Cancer Diagnosis in HIV Infected Population With an Important Smoking History With Low Dose CT: a Pilot Study

acronym: EP48 HIV CHEST

summary: Early Lung Cancer diagnosis in a HIV-infected population with an important smoking history with low-dose CT: a pilot study: the HIV-CHEST study Objectives The main objective of this study is to evaluate the prevalence of lung cancers detected by low-dose computed tomography (CT) in a HIV-infected population with an important smoking history. Other objectives are (1) the evaluation of the types of lung cancers in this population, as well as (2) the staging of non small cell lung cancers, (3) the description of risk factors for all lung cancers, if they are numerous enough, and (4) the number of complications of diagnosis procedures during the study.

primary_purpose: Screening

lead_sponsor: ANRS, Emerging Infectious Diseases

intervention_type: Radiation


title: Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis and Assessment by Neuroimaging

acronym: REACTIV

summary:
Despite the need for cognitive rehabilitation, there is a paucity of well-designed research studies to investigate treatment approaches or their effectiveness in MS. Most of published studies suffer from significant methodological flaws including small sample size, short follow-up periods, and lack of specific outcome criteria to determine improvement. O'Brien et al. (2008) recently reviewed 16 studies of cognitive rehabilitation designed to persons with MS and found only 4 class I studies and only one class I study of rehabilitation of attention deficits. Methodologically rigorous research is needed to confirm the preliminary results reported by these studies and determine the effectiveness and efficacy of cognitive rehabilitation interventions in attention deficits in MS. O'Brien et al. listed limitations found in previous studies that must be addressed in future studies. The present study was designed according to these recommendations. It is a randomized, controlled study, in parallel groups, evaluator blinded.

Number of participants: 25 RRMS patients in the active group, 25 RRMS patients in the control group and 25 healthy subjects.

The protocol will be proposed to RRMS patients AFFILIATED TO FRENCH SOCIAL SECURITY referred to the investigators center by practicing neurologists and fulfilling the inclusion criteria for screening.

Patients will be randomised between two groups. The active group (25 patients) will be treated by rehabilitation. Individual rehabilitation procedures will be focused on attention, executive functions and IPS. The program will be tailored to each patient cognitive status depending on the impairments identified during the initial assessment while maintaining a systematic work on attention and executive functions. A total of 50 sessions lasting one hour at a rate of 3 sessions per week for a total period of 4 months will be proposed. Patients randomized in the other group will participate to group session every week without specific cognitive rehabilitation. 25 healthy control subjects (group C), matched to patients for education, gender and age with patients of groups A/B will have the same evaluation procedures than patients.

Evaluation will be performed at baseline, after 4 months (end of treatment period) and after 8 months. Evaluation will include clinical testing, cognitive battery (paper/pencil and computer tests), cognitive ecological evaluation (Computer test of attention in a virtual reality environment and driving test on a driving simulator), questionnaires about daily life and MRI (fMRI and MRI). All patients and healthy subjects will undergo the fMRI protocol using a paradigm previously published by the investigators group (Bonnet et al., 2009): Go/No-go paradigm with increasing difficulty during four successive conditions (the Tonic Alertness task, Go/No-go (IG), reversal Go/No-go (RG), and complex Go/No-go (CG). In a previous study the investigators observed compensatory activation in MS patients as compared to healthy controls for the three first conditions and a saturation of compensatory processes for the more complex. In the present study, the investigators hypothesize that a similar pattern will occur at baseline and that cognitive rehabilitation will improve brain compensation at the fourth level of complexity.

ReferenceCitation: Moroso A, Ruet A, Lamargue-Hamel D, Munsch F, Deloire M, Coupé P, Ouallet JC, Planche V, Moscufo N, Meier DS, Tourdias T, Guttmann CR, Dousset V, Brochet B. Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):146-151. doi: 10.1136/jnnp-2016-313867. Epub 2016 Oct 27.

family: Moroso

full_name: Amandine Moroso

given: Amandine

family: Ruet

full_name: Aurélie Ruet

given: Aurélie

family: Lamargue-Hamel

full_name: Delphine Lamargue-Hamel

given: Delphine

family: Munsch

full_name: Fanny Munsch

given: Fanny

family: Deloire

full_name: Mathilde Deloire

given: Mathilde

family: Coupé

full_name: Pierrick Coupé

given: Pierrick

family: Ouallet

full_name: Jean-Christophe Ouallet

given: Jean-Christophe

family: Planche

full_name: Vincent Planche

given: Vincent

family: Moscufo

full_name: Nicolas Moscufo

given: Nicolas

family: Meier

full_name: Dominik S Meier

given: Dominik S

family: Tourdias

full_name: Thomas Tourdias

given: Thomas

family: Guttmann

full_name: Charles R G Guttmann

given: Charles R G

family: Dousset

full_name: Vincent Dousset

family: Brochet

full_name: Bruno Brochet

given: Bruno

journal_name: Journal of Neurology, Neurosurgery & Psychiatry

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Archive ouverte HAL

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

location_facility: Service de Neurologie - Pôle des Neurosciences Cliniques, CHU de Bordeaux.


title: Study of Prognostic Factors of Acute Splenic Sequestration in a Cohort of Sickle Cell Disease (SCD) Children Diagnosed at Birth

acronym: SSADREPA

summary:
Acute splenic sequestration is a frequent and life threatening complication occurring in approximately 10 % of homozygous children. Maximal incidence is between 6 and 18 months.

The investigators formulate the hypothesis that there are clinical, biological and genetic markers predictive of severe complications notably acute splenic sequestration in SCD children. The present research project thus aims at analyzing in a forward-looking way the profile of severity by analysing clinical, biological and genetic characteristics in a multicentric cohort of 60 SCD children

primary_purpose: Prevention

ReferenceCitation: Brousse V, El Hoss S, Bouazza N, Arnaud C, Bernaudin F, Pellegrino B, Guitton C, Odièvre-Montanié MH, Mames D, Brouzes C, Picard V, Nguyen-Khoa T, Pereira C, Lapouméroulie C, Pissard S, Gardner K, Menzel S, Le Van Kim C, Colin-Aronovicz Y, Buffet P, Mohandas N, Elie C, Maier-Redelsperger M, El Nemer W, de Montalembert M. Prognostic factors of disease severity in infants with sickle cell anemia: A comprehensive longitudinal cohort study. Am J Hematol. 2018 Nov;93(11):1411-1419. doi: 10.1002/ajh.25260. Epub 2018 Sep 21.

name: Service de Pédiatrie et Maladies Infectieuses; Hôpital Universitaire Necker-Enfants Malades; Paris France

name: UMR_S 1134 Biologie Intégrée du Globule Rouge; Université Sorbonne Paris Cité/Université Paris Diderot/INSERM/INTS/Laboratoire d'Excellence GR-Ex; Paris France

family: Brousse

full_name: Valentine Brousse

given: Valentine

family: El Hoss

full_name: Sara El Hoss

given: Sara

name: Unité de Recherche Clinique/Centre d'investigation clinique Paris Descartes Necker-Cochin; Assistance Publique-Hôpitaux de Paris; Paris France

name: Université Paris Descartes; EA7323, Sorbonne Paris Cité; Paris France

family: Bouazza

full_name: Naïm Bouazza

given: Naïm

name: Service de Pédiatrie; Centre Hospitalier Intercommunal de Créteil; Créteil France

family: Arnaud

full_name: Cécile Arnaud

given: Cécile

family: Bernaudin

full_name: Francoise Bernaudin

given: Francoise

name: Service de Pediatrie; Centre Hospitalier Poissy-Saint Germain; Poissy France

family: Pellegrino

full_name: Béatrice Pellegrino

given: Béatrice

name: Service de Pédiatrie, Hôpital Universitaire Kremlin-Bicêtre; Le Kremlin Bicêtre France

family: Guitton

full_name: Corinne Guitton

given: Corinne

name: Service de Pédiatrie, Hôpital Universitaire Armand Trousseau; Paris France

family: Odièvre-Montanié

full_name: Marie-Hélène Odièvre-Montanié

given: Marie-Hélène

name: Laboratoire d'Hématologie; Hôpital Universitaire Tenon; Paris France

family: Mames

full_name: David Mames

given: David

name: Laboratoires d'Hématologie et de Biochimie; Hôpital Universitaire Necker-Enfants Malades; Paris France

family: Brouzes

full_name: Chantal Brouzes

given: Chantal

name: Laboratoire d'Hématologie; Hôpital Universitaire Kremlin Bicêtre; Le Kremlin Bicêtre France

family: Picard

full_name: Véronique Picard

given: Véronique

family: Nguyen-Khoa

full_name: Thao Nguyen-Khoa

given: Thao

family: Pereira

full_name: Catia Pereira

given: Catia

family: Lapouméroulie

full_name: Claudine Lapouméroulie

given: Claudine

name: Laboratoire de Biochimie Génétique; Hôpital Universitaire Henri Mondor; Créteil France

family: Pissard

full_name: Serge Pissard

given: Serge

name: King's College London; Division of Cancer Studies; London UK

name: King's College Hospital NHS Foundation Trust; London UK

family: Gardner

full_name: Kate Gardner

given: Kate

family: Menzel

full_name: Stephan Menzel

given: Stephan

family: Le Van Kim

full_name: Caroline Le Van Kim

given: Caroline

family: Colin-Aronovicz

full_name: Yves Colin-Aronovicz

given: Yves

family: Buffet

full_name: Pierre Buffet

name: Red Cell Physiology Laboratory; New York Blood Center; New York New York

family: Mohandas

full_name: Narla Mohandas

given: Narla

family: Elie

full_name: Caroline Elie

family: Maier-Redelsperger

full_name: Micheline Maier-Redelsperger

given: Micheline


title: Assessment of Knee Arthrosis in Severely Obese Patients After Bariatric Surgery.

acronym: BASIK

summary:
Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after bariatric surgery.

Knee MRI is not currently part of the investigations preceding bariatric surgery.


title: Pharmacodynamic Study of 125 mg of Paracetamol Permucosal Administered by Sublingual and Buccal Route

summary:
Paracetamol is the analgesic most used, indicated in the symptomatic treatment of fever and pain of mild to moderate. It comes in different dosage forms intended for oral, intravenous and rectal.

The per-oral mucosal route is not used for the administration of paracetamol. It is a very interesting way for the rapid absorption of drugs such as nitrates used in angina pectoris, as it seeks a highly vascular area (the floor of the tongue or gingival groove) and allows very rapid action. In addition, the oral administration-oral mucosa, less restrictive than IV administration and faster than oral administration, seek a single medical procedure unattended after dosing, will entail no pain or risk for infections the patient (in contrast to the IV). The investigators tested a new oral dosage form permucosal (at 250mg/ml) of paracetamol and compared at pharmacological (pharmacokinetic and pharmacodynamic) with the only dosage form of reference used by the IV route in the protocol "Pilot study Pharmacology paracetamol administered oral permucosal PMB. It seems interesting now to reduce the dose by half permucosal to assess how changing the pharmacodynamics of the form permucosal to 125mg/ml. This form will be administered in oral permucosal buccal as well as sublingual (under the pillar of the language) and compared with paracetamol in IV.


ReferenceCitation: Assenat E, Mineur L, Mollevi C, Lopez-Crapez E, Lombard-Bohas C, Samalin E, Portales F, Walter T, de Forges H, Dupuy M, Boissière-Michot F, Ho-Pun-Cheung A, Ychou M, Mazard T. Phase II study evaluating the association of gemcitabine, trastuzumab and erlotinib as first-line treatment in patients with metastatic pancreatic adenocarcinoma (GATE 1). Int J Cancer. 2021 Feb 1;148(3):682-691. doi: 10.1002/ijc.33225. Epub 2020 Sep 2.

name: Medical Oncology Department, Institut du Cancer de Montpellier (ICM) Univ. Montpellier  Montpellier France

name: Centre Hospitalier Régional Universitaire (CHU) de Montpellier Univ. Montpellier  Montpellier France

family: Assenat

full_name: Eric Assenat

given: Eric

name: Unité de Cancérologie Digestive Oncologie Radiothérapie Institut Sainte Catherine  Avignon France

family: Mineur

full_name: Laurent Mineur

given: Laurent

name: Biometrics Unit, Institut du Cancer de Montpellier (ICM) University of Montpellier  Montpellier France

family: Mollevi

full_name: Caroline Mollevi

name: Translational Research Unit, Institut Régional du Cancer de Montpellier (ICM) University of Montpellier  Montpellier France

family: Lopez‐Crapez

full_name: Evelyne Lopez‐Crapez

given: Evelyne

name: Centre Hospitalier Edouard Herriot  Lyon France

family: Lombard‐Bohas

full_name: Catherine Lombard‐Bohas

given: Catherine

family: Samalin

full_name: Emmanuelle Samalin

given: Emmanuelle

family: Portales

full_name: Fabienne Portales

given: Fabienne

family: Walter

full_name: Thomas Walter

given: Thomas

name: Clinical Research and Innovation Department, Institut du Cancer de Montpellier (ICM) University of Montpellier  Montpellier France

family: Forges

full_name: Hélène Forges

given: Hélène

family: Dupuy

full_name: Marie Dupuy

given: Marie

family: Boissière‐Michot

full_name: Florence Boissière‐Michot

given: Florence

family: Ho‐Pun‐Cheung

full_name: Alexandre Ho‐Pun‐Cheung

given: Alexandre

family: Ychou

full_name: Marc Ychou

given: Marc

family: Mazard

full_name: Thibaut Mazard

given: Thibaut

journal_name: International Journal of Cancer

title: Phase II study evaluating the association of gemcitabine, trastuzumab and erlotinib as first‐line treatment in patients with metastatic pancreatic adenocarcinoma ( GATE 1)

lead_sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

acronym: GATE 1

title: Phase II Trial Evaluating the Combination of Gemcitabine, Trastuzumab and Erlotinib as First-line Chemotherapy in Patients With Metastatic Pancreatic Adenocarcinoma

summary:
GATE 1 is an open-label, non-comparative, multicentric study evaluating the efficacy and tolerance of the combined use of Gemcitabine, Trastuzumab and Erlotinib as a first-line chemotherapy in metastatic pancreatic cancer patients.

The patients will be treated intravenously with Gemcitabine at a dose of 1000 mg/m2 for 30 min. For the first eight weeks, Gemcitabine will be administered once weekly for 7 weeks followed by one week of rest. Subsequently, Gemcitabine will be administered once weekly for three weeks followed by one week of rest.

Trastuzumab will be administered once a week at a dose of 4 mg/kg over 90 min. at D1 and then at 2 mg/kg over 30 min. for the subsequent infusions.

Erlotinib will be administered orally at a dose of 100 mg/day from C1D1.

The patients will be subjected to research for the EGFR, HER2 and KRAS status.


title: Renal and Digestive Tolerance of a Food Supplement, Phytalgic, in Elderly Volunteers - A Multicentric Open Trial

summary: The aim of the study is to evaluate renal and digestive tolerance of a food supplement, phytalgic, on elderly volunteers.

lead_sponsor: Phythea

location_facility: Département de Pharmacologie Clinique - Université Victor Segalen Bordeaux 2 - CHU de Bordeaux

intervention_type: Dietary Supplement


title: Prospective Observational Study to Asses the Insulin Resistance (IR) and Its Impact on Sustained Virological Response in a Cohort of HCV-infected Patients Treated With Pegasys and Copegus

summary: This prospective observational study will assess the insulin resistance and its impact on sustained virological response in patients with hepatitis C treated with Pegasys and Copegus. Data will be collected from each patient during the up to 72 weeks of treatment and for 24 weeks of treatment-free follow-up.

lead_sponsor: Hoffmann-La Roche


title: Hypoxia Diagnosis and Evaluation Using F-MISO PET and Biomarkers in Brain Tumors

acronym: HYPONCO

summary:
Background :

In malignant gliomas, hypoxia is associated with tumour angiogenesis and tumour progression. This multidisciplinary preclinical and clinical project aims to validate the use of 18F-FMISO as a hypoxic marker for diagnosis, treatment and follow-up of malignant gliomas. Indeed, non-invasive methods of imagery such as Positron Emission Tomography (PET) and biological methods (after surgical resection) to detect the endogenous expression of factors induced by the hypoxia would allow to identify hypoxic areas. Identifying, with accuracy, the hypoxic areas could allow the clinicians to evaluate the response to the anti-angiogenic agents (preliminary validation in the preclinical project) and to optimize the combination of the anti-VEGF treatments with other conventional therapeutic approaches (radiotherapy, chemotherapy or other molecules).

Research project :

This research project includes 3 steps : first the investigators will establish the 18F-FMISO production technique for clinical application at CYCERON PET center. The second step consists in the preclinical validation of 18F-FMISO as a hypoxic marker and as a powerful tool for evaluating the therapeutical efficiency of anti-angiogenic treatment (sutent) in experimental rat gliomas. The third step is the clinical trial HypOnco. This research proposal aims to develop and use non invasive imaging methods (18F-FMISO with PET) and biological methods (after surgical resection) to detect hypoxic (HIF1 and HIF2) and angiogenic (VEGF and EPO) regions in different malignant gliomas with different degrees of vascularization (15 patients with grade III gliomas and 15 patients with grade IV glioblastomas). Within the same patient 18F-FMISO as a hypoxic index will be performed. A magnetic resonance imaging examination (MRI) including perfusion sequences and MR spectroscopy will also be assessed for each patient. Following this imaging protocol, surgical resection will be performed allowing us to study expression of endogenous factors induced by hypoxia and angiogenic factors by real time RT-PCR and in immunohistochemistry.

The data obtained will enable us to establish :

a hypoxic index (18F-FMISO with PET).
an index of hypoxic factor expression (HIFs)
an angiogenic index (VEGF, EPO, vascular markers)

The investigators will characterize the links between these data and also with the following parameters:

clinical (age, Karnofsky performance status, survival)
MR parameters included perfusion and spectroscopy
histological (necrosis, cellular proliferation, atypical cell abnormalities, vascularization).

Expected results and clinical advantages

To establish the 18F-FMISO production technique
To propose the 18F-FMISO as a non-invasive marker for efficacy of antiangiogenic treatment in a preclinical study.
To define the relationship between the 18F-FMISO uptake and tumour grade, patient survival, tumour recurrence, expression of hypoxic and angiogenic factors and tumour vascularisation.
To provide a hypoxic index in cerebral tumours from 18F-FMISO PET, allowing diagnosis and prognosis improvement for optimal treatment orientation and strategy.

In the field of the clinical applications, this tool will allow to :

Optimize radiotherapy treatment by identifying with accuracy, using 18F-FMISO PET, the most hypoxic areas which are also the most radio resistant.
Evaluate antiangiogenic therapy efficacy

primary_purpose: Diagnostic

lead_sponsor: University Hospital, Caen


title: Search for the Presence of Genetic Alteration in the Plasma of Patients With Stage II-III Colorectal Cancers: Prognosis Impact

acronym: ALGECOLS

summary:
Cancer is a DNA disease characterized by the presence of genetics alterations in cancer cells.

The recent studies underline that these recurring alterations must be considered as a good molecular marker. In fact, they could use for tumor DNA detection in different biological fluids.

So, the main purpose is to define the presence of circulating tumor DNA in the patients plasma with colorectal cancer, by the presence of mutation (KRAS, NRAS, BRAF, APC, TP53 and MIRCOSATELLIE instability).

These molecular analysis will be done both in tumor and plasma samples,

This trial allows to characterize the prognostic value of circulating tumoral DNA presence in colorectal cancer.

lead_sponsor: Assistance Publique - Hôpitaux de Paris


title: Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

acronym: EFAPRE

summary:
Results of liver transplantation, the best theoretical treatment for HCC, are limited by tumor recurrence. In order to limit this risk Milan criteria was proposed in 1996. However, these criteria are to restrictive and approximately 40% of patients denied by Milan criteria may be cured by liver transplantation.

The purpose of this study was thus to prospectively evaluate factors predicting tumor recurrence after liver transplantation for HCC and then to reassess criteria for liver transplantation.


title: Excision Limits of Oral Cavity Tumor by NARROW BAND IMAGING (NBI): Feasibility Trial

summary: This study evaluates the feasibility of the NBI technique in the detection of early cancer lesions.

lead_sponsor: Centre Oscar Lambret


intervention_type: Biological

acronym: ARACHILD

title: ARACHILD: A Multicentric, Double Blind Placebo-controlled Pilot Protocol to Study the Efficacy and Safety of an Epicutaneous Immunotherapy in Children Allergic to Peanut

summary: This study aims at showing that Epicutaneous Immunotherapy with peanut proteins is safe and efficacious for desensitizing children with peanut allergy.


title: Low Steroid Dose Combined With Mycophenolic Acid (Myfortic) Compared With High Dose Steroid for Minimal Change Nephrotic Syndrome

acronym: MSN

summary:
A multicenter, randomized, study will be performed to evaluate the efficacy of low dose steroid combined with mycophenolic acid (MyforticR) versus high dose steroid in inducing remission in adults with minimal change nephrotic syndrome (MCNS). One hundred and fourteen patients (CPP decision 2009-04-02-a5) will be included in this study. They will be randomly assigned to an open label treatment with either prednisone

1 mg/kg/day (arm A) or 0,5 mg/kg/day plus myforticR 1440 mg/day (arm B) for four weeks. The outcome will be compared during one-year follow up

ReferenceCitation: Rémy P, Audard V, Natella PA, Pelle G, Dussol B, Leray-Moragues H, Vigneau C, Bouachi K, Dantal J, Vrigneaud L, Karras A, Pourcine F, Gatault P, Grimbert P, Ait Sahlia N, Moktefi A, Daugas E, Rigothier C, Bastuji-Garin S, Sahali D; MSN Trial Investigators. An open-label randomized controlled trial of low-dose corticosteroid plus enteric-coated mycophenolate sodium versus standard corticosteroid treatment for minimal change nephrotic syndrome in adults (MSN Study). Kidney Int. 2018 Dec;94(6):1217-1226. doi: 10.1016/j.kint.2018.07.021. Epub 2018 Oct 29.

family: Rémy

full_name: Philippe Rémy

given: Philippe

family: Audard

full_name: Vincent Audard

given: Vincent

family: Natella

full_name: Pierre André Natella

given: Pierre André

family: Pelle

full_name: Gaëlle Pelle

given: Gaëlle

family: Dussol

full_name: Bertrand Dussol

given: Bertrand

family: Leray-Moragues

full_name: Helene Leray-Moragues

given: Helene

family: Vigneau

full_name: Cecile Vigneau

given: Cecile

family: Bouachi

full_name: Khedidja Bouachi

given: Khedidja

family: Dantal

full_name: Jacques Dantal

given: Jacques

family: Vrigneaud

full_name: Laurence Vrigneaud

given: Laurence

family: Karras

full_name: Alexandre Karras

family: Pourcine

full_name: Frank Pourcine

given: Frank

family: Gatault

full_name: Philippe Gatault

family: Grimbert

full_name: Philippe Grimbert

family: Ait Sahlia

full_name: Nawelle Ait Sahlia

given: Nawelle

family: Moktefi

full_name: Anissa Moktefi

given: Anissa

family: Daugas

full_name: Eric Daugas

family: Rigothier

full_name: Claire Rigothier

given: Claire

family: Bastuji-Garin

full_name: Sylvie Bastuji-Garin

given: Sylvie

family: Sahali

full_name: Dil Sahali

given: Dil

family: Aldigier

full_name: Jean Claude Aldigier

given: Jean Claude

family: Bataille

full_name: Pierre Bataille

given: Pierre

family: Canaud

full_name: Bernard Canaud

given: Bernard


title: Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome

acronym: ADISAS

summary:
The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP).

An interim analysis will be performed when 40 patients will be included.

status: Active, not recruiting

ReferenceCitation: Baguet JP, Hammer L, Lévy P, Pierre H, Launois S, Mallion JM, Pépin JL. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest. 2005 Nov;128(5):3407-12.

ReferenceCitation: Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003 Oct 8;290(14):1906-14. Review.

ReferenceCitation: Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007 Apr;56(4):901-11.

ReferenceCitation: Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005 Mar 19-25;365(9464):1046-53.

ReferenceCitation: Coughlin SR, Mawdsley L, Mugarza JA, Wilding JP, Calverley PM. Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur Respir J. 2007 Apr;29(4):720-7. Epub 2007 Jan 24.

ReferenceCitation: Lavie L. Obstructive sleep apnoea syndrome--an oxidative stress disorder. Sleep Med Rev. 2003 Feb;7(1):35-51. Review.

ReferenceCitation: Jullian-Desayes I, Tamisier R, Zarski JP, Aron-Wisnewsky J, Launois-Rollinat SH, Trocme C, Levy P, Joyeux-Faure M, Pepin JL. Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials. Respirology. 2016 Feb;21(2):378-85. doi: 10.1111/resp.12672. Epub 2015 Nov 16.

name: HP2; INSERM, U1042University Grenoble Alpes Grenoble France

family: Jullian‐Desayes

full_name: Ingrid Jullian‐Desayes

given: Ingrid

family: Tamisier

full_name: Renaud Tamisier

given: Renaud

name: Hepato‐Gastro‐Enterology DepartmentCHU Grenoble Grenoble France

family: Zarski

full_name: Jean‐Pierre Zarski

given: Jean‐Pierre

name: Endocrinology and Nutrition DepartmentAP‐HP, La Pitié‐Salpétrière, Hospital Paris France

name: Nutriomic DepartmentINSERM, UMRS 872, University Pierre and Marie Curie‐Paris 6 Paris France

family: Aron‐Wisnewsky

full_name: Judith Aron‐Wisnewsky

given: Judith

family: Launois‐Rollinat

full_name: Sandrine H. Launois‐Rollinat

given: Sandrine H.

name: Biochemistry, Toxicology and Pharmacology DepartmentCHU Grenoble Grenoble France

family: Trocme

full_name: Candice Trocme

given: Candice

family: Levy

full_name: Patrick Levy

given: Patrick

family: Joyeux‐Faure

full_name: Marie Joyeux‐Faure

given: Marie

family: Pepin

full_name: Jean‐Louis Pepin

given: Jean‐Louis

journal_name: Respirology

lead_sponsor: University Hospital, Grenoble


title: Postoperative Analgesia After Cardiac Surgery: Effects of a Continuous Infusion of Ropivacaine Through Laterosternal Catheters

summary: This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at the rate of 4 mL.hr-1 through two catheters inserted at the lateral edges of the sternum will be studied, versus a control group in which normal saline will be infused in the same conditions.

ReferenceCitation: Eljezi V, Dualé C, Azarnoush K, Skrzypczak Y, Sautou V, Pereira B, Tsokanis I, Schoeffler P. The analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery. Reg Anesth Pain Med. 2012 Mar-Apr;37(2):166-74. doi: 10.1097/AAP.0b013e318240957f.

family: Eljezi

full_name: Vedat Eljezi

given: Vedat

family: Dualé

full_name: Christian Dualé

given: Christian

family: Azarnoush

full_name: Kasra Azarnoush

given: Kasra

family: Skrzypczak

full_name: Yvan Skrzypczak

given: Yvan

family: Sautou

full_name: Valérie Sautou

given: Valérie

family: Pereira

full_name: Bruno Pereira

given: Bruno

family: Tsokanis

full_name: Ianis Tsokanis

given: Ianis

family: Schoeffler

full_name: Pierre Schoeffler

journal_name: Regional Anesthesia and Pain Medicine

title: The Analgesic Effects of a Bilateral Sternal Infusion of Ropivacaine After Cardiac Surgery


title: Evaluation of the Potential of Elastography for Noninvasive Assessment of Fibrosis in Kidney Transplant

acronym: GREFE

summary: The purpose of this study is to assess the potential of elastography for noninvasive assessment of fibrosis in renal allograft.

location_facility: Service de Radiologie, Pavillon P Radio, Hôpital Edouard Herriot


title: Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies. Impact of Lactulose and Carnitine Treatment.

acronym: AutoSop-Foie

summary: The project will improve scientific knowledge regarding a recent law applying potentially to every french driver. It will give for the first time an indication on the impact of alerting treatments on driving risks. It will reinforce the links between different research environments (sleep physiopathology, clinical research, cognitive neurosciences, drivers supervision, virtual reality, pharmacology) among the "Réseau Eveil Sommeil Attention et Transports" (RESAT) network.


title: Study of Bronchoalveolar Lung Remodeling in Subjects From 60 Years Free of Progressive Lung Disease: Structure-function Analysis

summary: The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

ReferenceCitation: Bommart S, Marin G, Bourdin A, Molinari N, Klein F, Hayot M, Vachier I, Chanez P, Mercier J, Vernhet-Kovacsik H. Relationship between CT air trapping criteria and lung function in small airway impairment quantification. BMC Pulm Med. 2014 Feb 28;14:29. doi: 10.1186/1471-2466-14-29.

family: Bommart

full_name: Sébastien Bommart

given: Sébastien

family: Marin

full_name: Grégory Marin

given: Grégory

family: Bourdin

full_name: Arnaud Bourdin

given: Arnaud

family: Molinari

full_name: Nicolas Molinari

given: Nicolas

family: Klein

full_name: François Klein

given: François

family: Hayot

full_name: Maurice Hayot

given: Maurice

family: Vachier

full_name: Isabelle Vachier

given: Isabelle

family: Chanez

full_name: Pascal Chanez

given: Pascal

family: Mercier

full_name: Jacques Mercier

given: Jacques

family: Vernhet-Kovacsik

full_name: Hélène Vernhet-Kovacsik

given: Hélène

journal_name: BMC Pulmonary Medicine

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - CentraleSupélec

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Archive ouverte HAL

lead_sponsor: University Hospital, Montpellier


title: Effects of Treatment of Post-traumatic Stress Disorder on Reduced Recall for Fear Extinction

summary: This preliminary study will examine the differential effects of rTMS on the recall of extinction of conditioned fear in patients suffering from PTSD (post-traumatic stress disorder ) compared with subjects without PTSD but with high risk of relapse.

lead_sponsor: Centre Hospitalier Universitaire de Nice


title: Treatment of Primary Peritoneal Carcinosis of Digestive Origin Using Cytoreductive Surgery and Hyperthermic Intraoperative Peritoneal Chemotherapy With Mitomycin C and Irinotecan

summary: This is an open, non-randomized, phase I-II, pilot study, which evaluates the combination of optimum cytoreductive surgery and hyperthermic intraoperative peritoneal chemotherapy (HIPEC) with mitomycin C (MMC) and irinotecan. The latter drug will be administered in escalating doses to patients with gastric, colorectal, appendicular, or primary peritoneal carcinosis (PC).

location_facility: Service de Chirurgie Générale et Thoracique, Centre Hospitalier Lyon-Sud


title: Assessment of Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning

acronym: Sevralox

summary: This study aims to assess the efficacy of a drug (loxapine, a neuroleptic) in calming patients down in a situation of restlessness during mechanical ventilation weaning. This drug is used for several years to quieten restless patients. Its purpose is to restore spontaneous breathing sooner and therefore to reduce the risks of intubation and mechanical ventilation.

ReferenceCitation: Gaudry S, Sztrymf B, Sonneville R, Megarbane B, Van Der Meersch G, Vodovar D, Cohen Y, Ricard JD, Hajage D, Salomon L, Dreyfuss D. Loxapine to control agitation during weaning from mechanical ventilation. Crit Care. 2017 Sep 6;21(1):235. doi: 10.1186/s13054-017-1822-y.

family: Gaudry

full_name: Stéphane Gaudry

given: Stéphane

family: Sztrymf

full_name: Benjamin Sztrymf

given: Benjamin

family: Sonneville

full_name: Romain Sonneville

given: Romain

family: Megarbane

full_name: Bruno Megarbane

family: Van Der Meersch

full_name: Guillaume Van Der Meersch

given: Guillaume

family: Vodovar

full_name: Dominique Vodovar

given: Dominique

family: Cohen

full_name: Yves Cohen

given: Yves

family: Ricard

full_name: Jean-Damien Ricard

given: Jean-Damien

family: Hajage

full_name: David Hajage

given: David

family: Salomon

full_name: Laurence Salomon

given: Laurence

family: Dreyfuss

full_name: Didier Dreyfuss

given: Didier

journal_name: Critical Care


ReferenceCitation: Goéré D, Glehen O, Quenet F, Guilloit JM, Bereder JM, Lorimier G, Thibaudeau E, Ghouti L, Pinto A, Tuech JJ, Kianmanesh R, Carretier M, Marchal F, Arvieux C, Brigand C, Meeus P, Rat P, Durand-Fontanier S, Mariani P, Lakkis Z, Loi V, Pirro N, Sabbagh C, Texier M, Elias D; BIG-RENAPE group. Second-look surgery plus hyperthermic intraperitoneal chemotherapy versus surveillance in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP-PRODIGE 15): a randomised, phase 3 study. Lancet Oncol. 2020 Sep;21(9):1147-1154. doi: 10.1016/S1470-2045(20)30322-3. Epub 2020 Jul 24.

family: Goéré

full_name: Diane Goéré

given: Diane

family: Glehen

full_name: Olivier Glehen

given: Olivier

family: Quenet

full_name: François Quenet

family: Guilloit

full_name: Jean-Marc Guilloit

given: Jean-Marc

family: Bereder

full_name: Jean-Marc Bereder

family: Lorimier

full_name: Gérard Lorimier

given: Gérard

family: Thibaudeau

full_name: Emilie Thibaudeau

given: Emilie

family: Ghouti

full_name: Laurent Ghouti

given: Laurent

family: Pinto

full_name: Amandine Pinto

given: Amandine

family: Tuech

full_name: Jean-Jacques Tuech

given: Jean-Jacques

family: Kianmanesh

full_name: Reza Kianmanesh

given: Reza

family: Carretier

full_name: Michel Carretier

given: Michel

family: Marchal

full_name: Frédéric Marchal

given: Frédéric

family: Arvieux

full_name: Catherine Arvieux

given: Catherine

family: Brigand

full_name: Cécile Brigand

given: Cécile

family: Meeus

full_name: Pierre Meeus

given: Pierre

family: Rat

full_name: Patrick Rat

given: Patrick

family: Durand-Fontanier

full_name: Sylvaine Durand-Fontanier

given: Sylvaine

family: Mariani

full_name: Pascale Mariani

given: Pascale

family: Lakkis

full_name: Zaher Lakkis

given: Zaher

family: Loi

full_name: Valeria Loi

given: Valeria

family: Pirro

full_name: Nicolas Pirro

given: Nicolas

family: Sabbagh

full_name: Charles Sabbagh

given: Charles

family: Texier

full_name: Matthieu Texier

given: Matthieu

family: Elias

full_name: Dominique Elias

title: Second-look surgery plus hyperthermic intraperitoneal chemotherapy versus surveillance in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP–PRODIGE 15): a randomised, phase 3 study

lead_sponsor: Gustave Roussy, Cancer Campus, Grand Paris

title: Multicentric Phase III Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" HIPEC (Hyperthermic Intraperitoneal Chemotherapy) in Colorectal Patients Initially Treated With Surgery and Adjuvant Chemotherapy Who Have a High Risk of Developing Colorectal Peritoneal Carcinomatosis

summary: Multicentric randomised trial. Patients with a high risk of developing colorectal Peritoneal Carcinomatosis (PC) after resection of their primary will be informed, will sign the consent and will be pre-registered. All patients will receive the current standard adjuvant treatment : 6 months of systemic chemotherapy (currently the Folfox-4 regimen which could be modified if the standard is modified). Then a work-up is done to exclude recurrence. The likelihood of a recurrence is low but if this occurs, the patient will not be randomised and will be treated with the best known treatment. If the work-up is negative, patients will be randomised to surveillance alone (control group) or exploratory laparotomy + HIPEC (experimental group).


lead_sponsor: University Hospital, Clermont-Ferrand

acronym: Interaction tropisétron / Granisétron - paracétamol

title: Comparative Study of the Influence of Two Antagonist Receptors 5-HT3, tropisétron and granisétron, on the Analgesic Effect of Paracétamol

summary: This is a Crossover study, double-blind, randomized, controlled versus placebo.


title: Study of Efficacy and Tolerance of Early Launching of Nocturnal Non Invasive Ventilation in Adults With Myotonic Dystrophy Type 1(DM1)

acronym: DYVINE

summary: This is a multicenter randomized controlled open labeled study testing efficacy and tolerance of early launching of night non invasive ventilation in patients with myotonic dystrophy type 1(DM1). The object of this project is to estimate the effects of the early introduction of non invasive ventilation on the arisen of complication (non expected hospitalization, tracheostomy even death) with regard to a simple respiratory follow-up in patients affected by myotonic dystrophy.

location_facility: Home ventilation unit and intensive care, centre of neuromuscular disease (Garches Mondor Necker Hendaye), Raymond Poincaré hospital Versailles Saint Quentin University.


title: Epidemiology of Adult Adult Pulmonary Langerhans Cell Histiocytosis - A Multicenter Cohort Study

summary:
Study objectives:

To estimate the incidence of pulmonary deterioration in adult pulmonary Langerhans cell histiocytosis
To assess the impact of tobacco discontinuation
Study Design Multicentric prospective cohort study
Main endpoint: Pulmonary deterioration
Sample size : 40 patients

ReferenceCitation: Tazi A, de Margerie C, Naccache JM, Fry S, Dominique S, Jouneau S, Lorillon G, Bugnet E, Chiron R, Wallaert B, Valeyre D, Chevret S. The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study. Orphanet J Rare Dis. 2015 Mar 14;10:30. doi: 10.1186/s13023-015-0249-2.

family: Tazi

full_name: Abdellatif Tazi

given: Abdellatif

family: de Margerie

full_name: Constance de Margerie

given: Constance

family: Naccache

full_name: Jean Marc Naccache

given: Jean Marc

family: Fry

full_name: Stéphanie Fry

given: Stéphanie

family: Dominique

full_name: Stéphane Dominique

given: Stéphane

family: Jouneau

full_name: Stéphane Jouneau

family: Lorillon

full_name: Gwenaël Lorillon

given: Gwenaël

family: Bugnet

full_name: Emmanuelle Bugnet

given: Emmanuelle

family: Chiron

full_name: Raphael Chiron

given: Raphael

family: Wallaert

full_name: Benoit Wallaert

given: Benoit

family: Valeyre

full_name: Dominique Valeyre

given: Dominique

family: Chevret

full_name: Sylvie Chevret

given: Sylvie

journal_name: Orphanet Journal of Rare Diseases

ReferenceCitation: Tazi A, de Margerie-Mellon C, Vercellino L, Naccache JM, Fry S, Dominique S, Jouneau S, Lorillon G, Bugnet E, Chiron R, Wallaert B, Valeyre D, Chevret S. Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis. Orphanet J Rare Dis. 2016 Feb 2;11:11. doi: 10.1186/s13023-016-0387-1.

family: de Margerie-Mellon

full_name: Constance de Margerie-Mellon

family: Vercellino

full_name: Laetitia Vercellino

given: Laetitia


title: Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism

summary: Our main objective is to assess whether aortic stiffness is a predictor of blood pressure response after surgery in patients with an aldosterone producing adenoma or a unilateral adrenal hyperplasia.

ipd_sharing: No

lead_sponsor: University Hospital, Toulouse