title: Study of R-ACVBP Regimen Supported by Pegfilgrastim in Previously Untreated Patients Aged From 18 to 60 Years With High-Risk Diffuse Large B-Cell Lymphoma (Age-adjusted Ipi >or= 2)

summary: Evaluation of the efficacy of a single injection of Pegfilgrastim (6mg) administered at day 3 of each cycle of R-ACVBP regimen during 4 cycles in patients with CD20+ diffuse large B-cell lymphoma presenting at least 2 adverse prognostic factor of the age-adjusted international prognostic index (Aa-IPI).

ReferenceCitation: Green MD, Koelbl H, Baselga J, Galid A, Guillem V, Gascon P, Siena S, Lalisang RI, Samonigg H, Clemens MR, Zani V, Liang BC, Renwick J, Piccart MJ; International Pegfilgrastim 749 Study Group. A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy. Ann Oncol. 2003 Jan;14(1):29-35.

ReferenceCitation: Holmes FA, O'Shaughnessy JA, Vukelja S, Jones SE, Shogan J, Savin M, Glaspy J, Moore M, Meza L, Wiznitzer I, Neumann TA, Hill LR, Liang BC. Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer. J Clin Oncol. 2002 Feb 1;20(3):727-31.

ReferenceCitation: Vose JM, Crump M, Lazarus H, Emmanouilides C, Schenkein D, Moore J, Frankel S, Flinn I, Lovelace W, Hackett J, Liang BC. Randomized, multicenter, open-label study of pegfilgrastim compared with daily filgrastim after chemotherapy for lymphoma. J Clin Oncol. 2003 Feb 1;21(3):514-9.

ReferenceCitation: Haioun C, Lepage E, Gisselbrecht C, Salles G, Coiffier B, Brice P, Bosly A, Morel P, Nouvel C, Tilly H, Lederlin P, Sebban C, Brière J, Gaulard P, Reyes F. Survival benefit of high-dose therapy in poor-risk aggressive non-Hodgkin's lymphoma: final analysis of the prospective LNH87-2 protocol--a groupe d'Etude des lymphomes de l'Adulte study. J Clin Oncol. 2000 Aug;18(16):3025-30.

ReferenceCitation: Copie-Bergman C, Cuillière-Dartigues P, Baia M, Briere J, Delarue R, Canioni D, Salles G, Parrens M, Belhadj K, Fabiani B, Recher C, Petrella T, Ketterer N, Peyrade F, Haioun C, Nagel I, Siebert R, Jardin F, Leroy K, Jais JP, Tilly H, Molina TJ, Gaulard P. MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study. Blood. 2015 Nov 26;126(22):2466-74. doi: 10.1182/blood-2015-05-647602. Epub 2015 Sep 15.

name: Assistance Publique–Hôpitaux de Paris, Groupe Henri Mondor–Albert Chenevier, Département de Pathologie, Creteil, France;

name: Universite Paris-Est, Faculté de Médecine, Unité Mixte de Recherche Scientifique 955, Créteil, France;

family: Copie-Bergman

full_name: Christiane Copie-Bergman

given: Christiane

name: Institut Gustave Roussy, Villejuif, France;

family: Cuillière-Dartigues

full_name: Peggy Cuillière-Dartigues

given: Peggy

family: Baia

full_name: Maryse Baia

given: Maryse

name: Assistance Publique–Hôpitaux de Paris, Hôpital Saint-Louis, Department of Pathology, Institut Universitaire d’Hématologie, Paris, France;

family: Briere

full_name: Josette Briere

given: Josette

name: Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Department of Hematology, Paris, France;

family: Delarue

full_name: Richard Delarue

given: Richard

name: Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Department of Pathology, Université Paris Descartes, Paris, France;

family: Canioni

full_name: Danielle Canioni

given: Danielle

name: Hospices Civils de Lyon, Université Claude Bernard Lyon-1, Service d’Hématologie, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Lyon, France;

family: Salles

full_name: Gilles Salles

given: Gilles

name: Centre Hospitalier Universitaire Bordeaux, Université de Bordeaux, EA2406, Bordeaux, France;

family: Parrens

full_name: Marie Parrens

name: Assistance Publique–Hôpitaux de Paris, Groupe Henri Mondor-Albert Chenevier, Unité Lymphoïde, Créteil, France;

family: Belhadj

full_name: Karim Belhadj

given: Karim

name: Assistance Publique–Hôpitaux de Paris, Hôpital Saint-Antoine, Department of Pathology, Paris, France;

family: Fabiani

full_name: Bettina Fabiani

given: Bettina

name: Service d’Hématologie, Institut Universitaire du Cancer, Toulouse, France;

family: Recher

full_name: Christian Recher

given: Christian

name: Department of Pathology, Hôpital Maisonneuve-Rosemont, Montreal, Canada;

family: Petrella

full_name: Tony Petrella

given: Tony

name: Pluridisciplinary Center for Oncology, University Hospital–Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;

family: Ketterer

full_name: Nicolas Ketterer

given: Nicolas

name: Centre de Lutte Contre le Cancer de Nice, Nice, France;

family: Peyrade

full_name: Frederic Peyrade

given: Frederic

family: Haioun

full_name: Corinne Haioun

given: Corinne

name: Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany;

family: Nagel

full_name: Inga Nagel

given: Inga

family: Siebert

full_name: Reiner Siebert

given: Reiner

name: Centre Henri Becquerel and INSERM Unité 918, Institut de Recherche et d'Innovation Biomédicale, Rouen, France;

family: Jardin

full_name: Fabrice Jardin

given: Fabrice

family: Leroy

full_name: Karen Leroy

given: Karen

name: Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Department of Biostatistics, Paris, France;

family: Jais

full_name: Jean-Philippe Jais

given: Jean-Philippe

family: Tilly

full_name: Herve Tilly

given: Herve

name: Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Department of Pathology, Université Paris Descartes, EA 7324, Paris, France

family: Molina

full_name: Thierry Jo Molina

given: Thierry Jo

family: Gaulard

location_facility: Service d'Hématologie Clinique - CHU Le Bocage

location_facility: Service d'Hématologie - Centre Hospitalier Lyon-Sud


title: Prospective, Multicentric, Observational Cohort Study for the Evaluation of Implant Survival in Patients With a Metal-on-Metal Pinnacle(R) Ultamet(TM) Device in Conventional Total Hip Joint Replacement.

summary: The objective is to evaluate the implant survival rate for patients implanted with a PINNACLE® ULTAMET™ Metal-on-Metal implant for conventional total hip arthroplasty for the treatment of a severe hip disease and true femoral cervical fracture.

status: Completed

study_completion_date_type: Actual

study_type: Observational

time_perspective: Prospective

enrollment_type: Actual

ReferenceType: background

ReferenceCitation: Harris WH. Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. J Bone Joint Surg Am. 1969 Jun;51(4):737-55.

lead_sponsor: DePuy International

location_facility:
Clinique Bonnefon
Clinique Herbert
Clinique Saint Hilaire
Clinique Pasteur
Centre Hospitalier Georges Renon
Clinique Mutualiste Saint Etienne

intervention_type: Device

lead_sponsor_type: industriel

status_simplified: Completed


title: A Phase II Study of the BRAF Inhibitor Encorafenib in Combination With the MEK Inhibitor Binimetinib in Patients With BRAFV600E-mutant Metastatic Non-small Cell Lung Cancer

acronym: ENCO-BRAF

summary: A Phase II study of the BRAF inhibitor Encorafenib in combination with the MEK inhibitor Binimetinib in Patients with BRAFV600E-mutant metastatic Non-small Cell Lung Cancer

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Anticipated

ipd_sharing: Undecided

lead_sponsor: Intergroupe Francophone de Cancerologie Thoracique

location_facility: Villefranche-Sur-Saône - Hôpital Nord-Ouest

location_facility: Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg

location_facility: Nancy - Institut de Cancérologie de Lorraine

location_facility: Centre Hospitalier Intercommunal de Créteil

intervention_type: Drug

status_simplified: Ongoing


title: Cardiac Arrest Incidence and Outcome Among Patient With COVID-19 Pneumonia in French ICUs

acronym: ACICOVID

summary:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic. Among COVID-19 complications, in-hospital cardiac arrest (IHCA) was reported with a very poor outcome in a retrospective single-center study (0,7% of 30 days survival with good neurological outcome among IHCA patients with a resuscitation attempt), related to its natural course and management. The incidence of unexpected in-ICU cardiac arrest (ICUCA) due to COVID-19 is still unknown. Additionally, outcome of COVID-19 patients admitted in ICU for an out-of-hospital cardiac arrest (OHCA) is also undescribed.

The objective this study is :

to report the incidence of ICUCA among patients hospitalized in French ICU for COVID-19.
to report morbidity and mortality among COVID-19 patients admitted alive in ICU for an OHCA or an IHCA.

The secondary objective is to assess outcome and identify risk factors of ICUCA occurrence among patients admitted for COVID-19.

ReferenceCitation: Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.

name: From the NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (N.Z., W.W., J.S., X.Z., B.H., R.L., P.N., X.M., D.W., W.X., G.W., G.F.G., W.T.), and the Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University (X.L.) — both in Beijing; Wuhan Jinyintan Hospital (D.Z.), the Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention (B.Y., F.Z.), and...

family: Zhu

full_name: Na Zhu

sequence: first

family: Zhang

full_name: Dingyu Zhang

given: Dingyu

sequence: additional

family: Wang

full_name: Wenling Wang

given: Wenling

family: Li

full_name: Xingwang Li

given: Xingwang

family: Yang

full_name: Bo Yang

given: Bo

family: Song

full_name: Jingdong Song

given: Jingdong

family: Zhao

full_name: Xiang Zhao

given: Xiang

family: Huang

full_name: Baoying Huang

given: Baoying

family: Shi

full_name: Weifeng Shi

given: Weifeng

family: Lu

full_name: Roujian Lu

given: Roujian

family: Niu

full_name: Peihua Niu

given: Peihua

family: Zhan

full_name: Faxian Zhan

given: Faxian

family: Ma

full_name: Xuejun Ma

given: Xuejun

full_name: Dayan Wang

given: Dayan

family: Xu

full_name: Wenbo Xu

given: Wenbo

family: Wu

full_name: Guizhen Wu

given: Guizhen

family: Gao

full_name: George F. Gao

given: George F.

family: Tan

full_name: Wenjie Tan

given: Wenjie

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: New England Journal of Medicine

oa_colors: green other

oa_host_type: publisher;repository

evidence: open (via free article)

host_type: publisher

license_normalized: no license

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

license: implied-oa

license_normalized: implied-oa

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

ReferenceCitation: Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

name: From the State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University (W.G., W.L., J.H., R.C., C.T., T.W., S.L., Jin-lin Wang, N.Z., J.H., W.L.), the Departments of Thoracic Oncology (W.L.), Thoracic Surgery and Oncology (J.H.), and Emergency Medicine (Z.L.), First Affiliated Hospital of Guangzhou Medical University, and Guangzhou Eighth People’s Hospital,...

ReferenceCitation: Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 May;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5. Epub 2020 Feb 24. Erratum in: Lancet Respir Med. 2020 Apr;8(4):e26.

ReferenceCitation: Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A; COVID-19 Lombardy ICU Network. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020 Apr 28;323(16):1574-1581. doi: 10.1001/jama.2020.5394. Erratum in: JAMA. 2021 May 25;325(20):2120.

ReferenceCitation: Leloup M, Briatte I, Langlois A, Cariou A, Lesieur O; ACIR study group. Unexpected cardiac arrests occurring inside the ICU: outcomes of a French prospective multicenter study. Intensive Care Med. 2020 May;46(5):1005-1015. doi: 10.1007/s00134-020-05992-w. Epub 2020 Mar 9.

ReferenceCitation: Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020 May - Jun;14(3):247-250. doi: 10.1016/j.dsx.2020.03.013. Epub 2020 Mar 25. Review.

ReferenceCitation: Chen C, Zhou Y, Wang DW. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020 May;45(3):230-232. doi: 10.1007/s00059-020-04909-z.

ReferenceCitation: Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, Wang H, Wan J, Wang X, Lu Z. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 Jul 1;5(7):811-818. doi: 10.1001/jamacardio.2020.1017. Erratum in: JAMA Cardiol. 2020 Jul 1;5(7):848.

ReferenceCitation: Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 Jul 1;5(7):831-840. doi: 10.1001/jamacardio.2020.1286. Review.

ReferenceCitation: Wu CI, Postema PG, Arbelo E, Behr ER, Bezzina CR, Napolitano C, Robyns T, Probst V, Schulze-Bahr E, Remme CA, Wilde AAM. SARS-CoV-2, COVID-19, and inherited arrhythmia syndromes. Heart Rhythm. 2020 Sep;17(9):1456-1462. doi: 10.1016/j.hrthm.2020.03.024. Epub 2020 Mar 31. Review.

ReferenceCitation: Shao F, Xu S, Ma X, Xu Z, Lyu J, Ng M, Cui H, Yu C, Zhang Q, Sun P, Tang Z. In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan, China. Resuscitation. 2020 Jun;151:18-23. doi: 10.1016/j.resuscitation.2020.04.005. Epub 2020 Apr 10.

ReferenceCitation: Chan PS, Berg RA, Nadkarni VM. Code Blue During the COVID-19 Pandemic. Circ Cardiovasc Qual Outcomes. 2020 May;13(5):e006779. doi: 10.1161/CIRCOUTCOMES.120.006779. Epub 2020 Apr 7.

ReferenceCitation: Mahase E, Kmietowicz Z. Covid-19: Doctors are told not to perform CPR on patients in cardiac arrest. BMJ. 2020 Mar 29;368:m1282. doi: 10.1136/bmj.m1282.

ReferenceCitation: Perkins GD, Jacobs IG, Nadkarni VM, Berg RA, Bhanji F, Biarent D, Bossaert LL, Brett SJ, Chamberlain D, de Caen AR, Deakin CD, Finn JC, Gräsner JT, Hazinski MF, Iwami T, Koster RW, Lim SH, Ma MH, McNally BF, Morley PT, Morrison LJ, Monsieurs KG, Montgomery W, Nichol G, Okada K, Ong ME, Travers AH, Nolan JP; Utstein Collaborators. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Resuscitation. 2015 Nov;96:328-40. doi: 10.1016/j.resuscitation.2014.11.002. Epub 2014 Nov 11.

ReferenceCitation: Chelly J, Plantefève G, Kamel T, Bruel C, Nseir S, Lai C, Cirillo G, Skripkina E, Ehrminger S, Berdaguer-Ferrari FD, Le Marec J, Paul M, Autret A, Deye N; ACICOVID-19 study group. Incidence, clinical characteristics, and outcome after unexpected cardiac arrest among critically ill adults with COVID-19: insight from the multicenter prospective ACICOVID-19 registry. Ann Intensive Care. 2021 Nov 13;11(1):155. doi: 10.1186/s13613-021-00945-y.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

lead_sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

location_facility: Centre Hospitalier Intercommunal Toulon La Seyne sur Mer


status: Terminated

lead_sponsor: University Hospital, Tours

acronym: RALIB

location_facility: University Hospital of Bordeaux-St.André

type: EudraCT Number

source: euctr

title: Efficacy of Topical Rapamycin in Treatment of Chronic Erosive Oral Lichen Planus. Double Blind Randomised Controlled Trial Rapamycin vs Topical Steroids

summary: The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.

lead_sponsor_type: academique

status_simplified: Unknown


type: Registry Identifier

title: Therapeutic and Support Oncologic Medical Care Evaluation in Patients With Multiple Myeloma in West-Occitanie Region. Factors Influencing Medical Care and Predictive and Prognostic Impact.

acronym: VAMOS

summary:
Actually very few real life data are available for patients with multiple myeloma (MM), whereas they're playing a more and more important role in health care decisions. Treatments choice for medical care of patient with MM depends of their age, their general status, their eligibility to high dose treatment (autograft), and also based on cytogenetic risk (standard/high risk). Therapeutic strategies are multple and based on drugs associations including proteasome inhibitors, immuno-modulators and monoclonal antibodies.

Therapeutic medical care objective is to improve quality and response duration through more effective induction schemas, systematic consolidation for patients who have undergone high dose therapy and/or maintenance treatment, ensuring patients safety and well-being in the health care pathway.

Quality of life evaluation has to take in consideration disease outcome and secondary effects impact from treatments prescribed for MM.

With clinical trials, new therapeutic strategies are proposed with innovative drugs but participants are selected and do not represent all patients with MM. Therefore, there is a large gap between clinical trials and real life data.

That's why the CHU Toulouse intends to set up a prospective cohort to evaluate the health care pathway of patients with MM in West-Occitanie region and studies impact of treatments prescribed on the disease and on the patients' quality of life.

With this research, standard of care practices for patients with MM will be followed, prognostic scores and clinical trials results will be validated in real life, impact of outpatient support procedure will be assessed (AMA procedure) and sociodemographic/quality of life data will be available for research teams.

study_start_date_type: Anticipated

status: Not yet recruiting

time_perspective: Retrospective

lead_sponsor: University Hospital, Toulouse

location_facility: IUCT-Oncopole - Toulouse University Hospital

intervention_type: Other


title: Seroprevalence and Antibody Profiling Against SARS-CoV2 in Children and Their Parents

acronym: PED-COVID

summary: The purpose of this study is to provide data on the proportion of seroconverted children and their immune status. It will also provide insight into the number of children currently infected at each time point including healthy carriers. Investigators will provide similar data on their parents in an ancillary study.

design_allocation: Non-Randomized

primary_purpose: Diagnostic

ipd_sharing: No

lead_sponsor: Assistance Publique - Hôpitaux de Paris

intervention_type: Biological


title: MIF : a New Target to Eradicate the Pre-leukemic Clone in Acute Myeloid Leukemia

acronym: MIFAML

summary:
This study is an observational study of MIF involvement in retrospectively and prospectively included adult acute myeloid leukemia (AML). Standard care samples collected at diagnosis, after one course of treatment, at time of remission controls, and at time of relapse will be used.

The first objective is to determine which AMLs have pre-leukemic stem cells that overexpress MIF. Cytogenetic and molecular (NGS) profiling will be performed at diagnosis. Blood and bone marrow plasma, as well as bone marrow mononuclear cells will be collected and stored. The expression of MIF and its receptor (CD74 and CXCR4) will be analysed. Their prognostic value will be also tested.

The second objective is to test whether patients in complete remission have persistent pre-leukemic stem cells that overexpress MIF. Blood and bone marrow plasma, bone marrow mononuclear cells from patients in complete remission will be collected. MIF, CD74, and CXCR4 expression by hematopoietic cells at time of diagnosis and remission will be compared to determine which patients have a persistent overexpression/secretion of MIF. In the meantime, the persistence of initiating lesions in complete remission samples will be tested by NGS, digital PCR, FISH, or RT-PCR methods.

The third objective is to develop a pre-clinical model to target MIF in immuno-compromised mice (NSG mice) transplanted with primary AML cells and cells with pre-leukemic lesions. TET2 depletion leads to MIF over-expression/secretion by hematopoietic cells and improved multi-lineage NSG-repopulation capacity. MIF inhibitors and anti-MIF antibodies will be tested in these pre-clinical TET2-depleted models. Xenotransplantation of selected primary AML samples and xenotransplantation of TET2 depleted hematopoietic stem cells into NSG mice will be used.

The fourth objective is to understand how MIF is deregulated in pre-leukemic stem cells and how the MIF-dependent crosstalk between mesenchymal stromal cells (MSCs) and pre-leukemic stem cells or normal hematopoietic cells works.

The molecular mechanisms of MIF overexpression will be analyzed in hematopoietic stem and progenitor cells from normal and leukemic bone marrow, with a focus on cells depleted in TET2 or DNMT3A. To study the cross-talk between hematopoietic stem and progenitor cells, pre-leukemic stem cells, and bone marrow MSCs, co-culture experiments will be performed using available MSC cell lines and primary MSCs from healthy donors.

time_perspective: Other

location_facility: Laboratoire d'hématologie Hôpital Saint Antoine


title: The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors

summary:
The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.

https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en

ReferenceType: result

ReferenceCitation: Hercberg S, Castetbon K, Czernichow S, Malon A, Mejean C, Kesse E, Touvier M, Galan P. The Nutrinet-Santé Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status. BMC Public Health. 2010 May 11;10:242. doi: 10.1186/1471-2458-10-242.

family: Hercberg

full_name: Serge Hercberg

given: Serge

family: Castetbon

full_name: Katia Castetbon

given: Katia

family: Czernichow

full_name: Sébastien Czernichow

given: Sébastien

family: Malon

full_name: Aurélie Malon

given: Aurélie

family: Mejean

full_name: Caroline Mejean

given: Caroline

family: Kesse

full_name: Emmanuelle Kesse

given: Emmanuelle

family: Touvier

full_name: Mathilde Touvier

given: Mathilde

family: Galan

full_name: Pilar Galan

given: Pilar

currency_apc_doaj: GBP

journal_name: BMC Public Health

oa_colors: green gold

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

repository_institution: Université Libre de Bruxelles - Dépôt institutionnel de l'Université libre de Bruxelles

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Sorbonne Paris Nord

repository_normalized: HAL

repositories:
HAL
PubMed Central
dipot.ulb.ac.be

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Sorbonne Paris Nord

repositories_institution: Université Libre de Bruxelles - Dépôt institutionnel de l'Université libre de Bruxelles

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer

publisher_group: Springer

publisher_normalized: Springer

ReferenceType: derived

ReferenceCitation: Deschasaux-Tanguy M, Srour B, Bourhis L, Arnault N, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Allègre J, Allès B, Andreeva VA, Baudry J, Fezeu LK, Galan P, Julia C, Kesse-Guyot E, Péneau S, Hercberg S, Bajos N, Severi G, Zins M, de Lamballerie X, Carrat F, Touvier M; SAPRIS-SERO study group. Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort. BMC Med. 2021 Nov 30;19(1):290. doi: 10.1186/s12916-021-02168-1.

family: Deschasaux-Tanguy

full_name: Mélanie Deschasaux-Tanguy

given: Mélanie

family: Srour

full_name: Bernard Srour

given: Bernard

family: Bourhis

full_name: Laurent Bourhis

given: Laurent

family: Arnault

name: on behalf of the SAPRIS-SERO study group

title: Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort

ReferenceCitation: Debras C, Chazelas E, Srour B, Julia C, Kesse-Guyot E, Zelek L, Agaësse C, Druesne-Pecollo N, Andreeva VA, Galan P, Hercberg S, Latino-Martel P, Deschasaux-Tanguy M, Touvier M. Glycaemic index, glycaemic load and cancer risk: results from the prospective NutriNet-Santé cohort. Int J Epidemiol. 2021 Sep 7. pii: dyab169. doi: 10.1093/ije/dyab169. [Epub ahead of print]

title: OUP accepted manuscript

ReferenceCitation: Carra MC, Fessi S, Detzen L, Darnaud C, Julia C, Hercberg S, Touvier M, Andreeva VA, Bouchard P. Self-reported periodontal health and incident hypertension: longitudinal evidence from the NutriNet-Santé e-cohort. J Hypertens. 2021 Dec 1;39(12):2422-2430. doi: 10.1097/HJH.0000000000002941.

publisher: Ovid Technologies (Wolters Kluwer Health)

title: Self-reported periodontal health and incident hypertension

ReferenceCitation: Schneider E, Sabate JM, Bouchoucha M, Debras C, Touvier M, Hercberg S, Benamouzig R, Buscail C, Julia C. FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort. J Nutr. 2021 Oct 1;151(10):3180-3186. doi: 10.1093/jn/nxab207.

name: Equipe de recherche en épidémiologie nutritionnelle (EREN), Université Sorbonne Paris Nord, INSERM U1153, INRAE U1125, CRESS, Bobigny, France

name: Service de Gastroentérologie, Avicenne Hospital, APHP, Bobigny, France

name: INSERM U-987, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France

name: Department of Public Health, Avicenne Hospital, APHP, Bobigny, France

title: FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort

ReferenceCitation: Courtois F, Péneau S, Salanave B, Andreeva VA, Roland-Cachera MF, Touvier M, Galan P, Hercberg S, Fezeu LK. Trends in breastfeeding practices and mothers' experience in the French NutriNet-Santé cohort. Int Breastfeed J. 2021 Jul 2;16(1):50. doi: 10.1186/s13006-021-00397-x.

title: Trends in breastfeeding practices and mothers’ experience in the French NutriNet-Santé cohort

ReferenceCitation: Julia C, Leroy P, Adjibade M, Assmann KE, Touvier M, Hercberg S, Soler LG, Kesse-Guyot E. Public health potential of guidelines-based dietary scores for non-communicable diseases mortality prevention: simulation study using the Preventable Risk Integrated ModEl (PRIME) model. Public Health Nutr. 2021 Nov;24(16):5539-5549. doi: 10.1017/S1368980021002871. Epub 2021 Jul 2.

title: Public health potential of guidelines-based dietary scores for non-communicable diseases mortality prevention: simulation study using the PRIME model

ReferenceCitation: Deschasaux-Tanguy M, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Allès B, Andreeva VA, Baudry J, Charreire H, Deschamps V, Egnell M, Fezeu LK, Galan P, Julia C, Kesse-Guyot E, Latino-Martel P, Oppert JM, Péneau S, Verdot C, Hercberg S, Touvier M. Diet and physical activity during the coronavirus disease 2019 (COVID-19) lockdown (March-May 2020): results from the French NutriNet-Santé cohort study. Am J Clin Nutr. 2021 Apr 6;113(4):924-938. doi: 10.1093/ajcn/nqaa336.

name: Sorbonne Paris Nord University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Conservatoire National des Arts et Métiers (CNAM), Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center–University of Paris (CRESS), Bobigny, France

name: Paris-Est University, Lab'Urba, Université Paris-Est Créteil (UPEC), Créteil, France

name: Nutritional Surveillance and Epidemiology Team (ESEN), French Public Health Agency, Sorbonne Paris Nord University, Epidemiology and Statistics Research Center–University of Paris (CRESS), Bobigny, France

name: Department of Public Health, Paris Seine-Saint-Denis University Hospital System, Assistance Publique - Hôpitaux de Paris (AP-HP), Bobigny, France

name: Department of Nutrition, Institute of Cardiometabolism and Nutrition, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France

journal_name: The American Journal of Clinical Nutrition

title: Diet and physical activity during the coronavirus disease 2019 (COVID-19) lockdown (March–May 2020): results from the French NutriNet-Santé cohort study

ReferenceCitation: Egnell M, Boutron I, Péneau S, Ducrot P, Touvier M, Galan P, Buscail C, Porcher R, Ravaud P, Hercberg S, Kesse-Guyot E, Julia C. Randomised controlled trial in an experimental online supermarket testing the effects of front-of-pack nutrition labelling on food purchasing intentions in a low-income population. BMJ Open. 2021 Feb 8;11(2):e041196. doi: 10.1136/bmjopen-2020-041196.

ReferenceCitation: Mervant L, Tremblay-Franco M, Jamin EL, Kesse-Guyot E, Galan P, Martin JF, Guéraud F, Debrauwer L. Osmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study. Metabolomics. 2021 Jan 2;17(1):2. doi: 10.1007/s11306-020-01758-z.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

ReferenceCitation: Kesse-Guyot E, Rebouillat P, Payrastre L, Allès B, Fezeu LK, Druesne-Pecollo N, Srour B, Bao W, Touvier M, Galan P, Hercberg S, Lairon D, Baudry J. Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study. Int J Behav Nutr Phys Act. 2020 Nov 9;17(1):136. doi: 10.1186/s12966-020-01038-y.

journal_name: International Journal of Behavioral Nutrition and Physical Activity

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

ReferenceCitation: Chazelas E, Debras C, Srour B, Fezeu LK, Julia C, Hercberg S, Deschasaux M, Touvier M. Sugary Drinks, Artificially-Sweetened Beverages, and Cardiovascular Disease in the NutriNet-Santé Cohort. J Am Coll Cardiol. 2020 Nov 3;76(18):2175-2177. doi: 10.1016/j.jacc.2020.08.075.

journal_name: Journal of the American College of Cardiology

title: Sugary Drinks, Artificially-Sweetened Beverages, and Cardiovascular Disease in the NutriNet-Santé Cohort

ReferenceCitation: Debras C, Chazelas E, Srour B, Kesse-Guyot E, Julia C, Zelek L, Agaësse C, Druesne-Pecollo N, Galan P, Hercberg S, Latino-Martel P, Deschasaux M, Touvier M. Total and added sugar intakes, sugar types, and cancer risk: results from the prospective NutriNet-Santé cohort. Am J Clin Nutr. 2020 Nov 11;112(5):1267-1279. doi: 10.1093/ajcn/nqaa246.

name: Sorbonne Paris Nord University, INSERM U1153, INRAe U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center—University of Paris (CRESS), Bobigny, France

name: Public Health Department, Avicenne Hospital, AP-HP, Bobigny, France

name: Oncology Department, Avicenne Hospital, AP-HP, Bobigny, France

ReferenceCitation: Beslay M, Srour B, Méjean C, Allès B, Fiolet T, Debras C, Chazelas E, Deschasaux M, Wendeu-Foyet MG, Hercberg S, Galan P, Monteiro CA, Deschamps V, Calixto Andrade G, Kesse-Guyot E, Julia C, Touvier M. Ultra-processed food intake in association with BMI change and risk of overweight and obesity: A prospective analysis of the French NutriNet-Santé cohort. PLoS Med. 2020 Aug 27;17(8):e1003256. doi: 10.1371/journal.pmed.1003256. eCollection 2020 Aug.

ReferenceCitation: Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Touvier M, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults. Eur J Nutr. 2021 Apr;60(3):1475-1488. doi: 10.1007/s00394-020-02344-8. Epub 2020 Jul 30.

ReferenceCitation: Gehring J, Touvier M, Baudry J, Julia C, Buscail C, Srour B, Hercberg S, Péneau S, Kesse-Guyot E, Allès B. Consumption of Ultra-Processed Foods by Pesco-Vegetarians, Vegetarians, and Vegans: Associations with Duration and Age at Diet Initiation. J Nutr. 2021 Jan 4;151(1):120-131. doi: 10.1093/jn/nxaa196.

name: Université de Paris, CRESS, INSERM, INRAE, Bobigny, France

name: Université Sorbonne Paris Nord, CRESS, INSERM, INRAE, Bobigny, France

name: Department of Public Health, Avicenne Hospital, Bobigny, France

ReferenceCitation: Partula V, Deschasaux M, Druesne-Pecollo N, Latino-Martel P, Desmetz E, Chazelas E, Kesse-Guyot E, Julia C, Fezeu LK, Galan P, Hercberg S, Mondot S, Lantz O, Quintana-Murci L, Albert ML, Duffy D; Milieu Intérieur Consortium, Srour B, Touvier M. Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort. Am J Clin Nutr. 2020 Jul 1;112(1):195-207. doi: 10.1093/ajcn/nqaa063.

name: Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Centre—University of Paris (CRESS), Bobigny, France

name: Université de Paris, Université Paris-VII Denis Diderot, Paris, France

name: Department of Public Health, Hôpital Avicenne (Hôpitaux Universitaires 93/AP-HP), Bobigny, France

name: MICALIS (INRAE/Université Paris-Saclay—AgroParisTech), Jouy-en-Josas, France

name: Curie Institute, PSL University, INSERM U932, Paris, France

name: Clinical Investigation Center CIC-BT1428 (Institut Gustave Roussy/Institut Curie), INSERM, Paris, France

name: Human Evolutionary Genetics laboratory (CNRS URA3012/Institut Pasteur), Paris, France

name: Department of Immunology and Infectious Diseases, Insitro, San Fransisco, CA, USA

name: Immunobiology of Dendritic Cells laboratory (INSERM U1223/Institut Pasteur), Paris, France

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Institut Pasteur

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Institut Pasteur

ReferenceCitation: Chaltiel D, Julia C, Adjibade M, Touvier M, Hercberg S, Kesse-Guyot E. Adherence to the 2017 French dietary guidelines and adult weight gain: A cohort study. PLoS Med. 2019 Dec 30;16(12):e1003007. doi: 10.1371/journal.pmed.1003007. eCollection 2019 Dec.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - SHS

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - CHU de Clermont-Ferrand

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - CHU de Clermont-Ferrand

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - SHS

title: Adherence to the 2017 French dietary guidelines and adult weight gain: A cohort study

ReferenceCitation: Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Debras C, Druesne-Pecollo N, Chazelas E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants of the NutriNet-Santé Prospective Cohort. JAMA Intern Med. 2020 Feb 1;180(2):283-291. doi: 10.1001/jamainternmed.2019.5942.

name: Paris 13 University, Inserm, Inra, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center–University of Paris (CRESS), 93017 Bobigny, France

name: Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr Arnaldo 715, São Paulo 01246-904, Brazil

ReferenceCitation: Seconda L, Egnell M, Julia C, Touvier M, Hercberg S, Pointereau P, Lairon D, Allès B, Kesse-Guyot E. Association between sustainable dietary patterns and body weight, overweight, and obesity risk in the NutriNet-Santé prospective cohort. Am J Clin Nutr. 2020 Jul 1;112(1):138-149. doi: 10.1093/ajcn/nqz259.

name: Paris 13 University, Research Team in Nutritional Epidemiology, Epidemiology and Statistics Center Sorbonne Paris Cité, National Institute for Health and Medical Research (U1153), National Institute for Agricultural Research (U1125), National Conservatory of Arts and Crafts, COMUE Sorbonne Paris Cité, Bobigny, France

name: Environment and Energy Management Agency, Angers, France

name: Public Health Department, Avicenne Hospital, Bobigny, France

name: Aix Marseille University, National Institute for Health and Medical Research, National Institute for Agricultural Research, C2VN, Marseille, France

name: Timone Faculty of Medicine, Marseille, France

ReferenceCitation: Andrianasolo RM, Hercberg S, Kesse-Guyot E, Druesne-Pecollo N, Touvier M, Galan P, Varraso R. Association between dietary fibre intake and asthma (symptoms and control): results from the French national e-cohort NutriNet-Santé. Br J Nutr. 2019 Nov 14;122(9):1040-1051. doi: 10.1017/S0007114519001843.

ReferenceCitation: Chazelas E, Srour B, Desmetz E, Kesse-Guyot E, Julia C, Deschamps V, Druesne-Pecollo N, Galan P, Hercberg S, Latino-Martel P, Deschasaux M, Touvier M. Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort. BMJ. 2019 Jul 10;366:l2408. doi: 10.1136/bmj.l2408.

title: Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort

ReferenceCitation: Adjibade M, Lemogne C, Touvier M, Hercberg S, Galan P, Assmann KE, Julia C, Kesse-Guyot E. The Inflammatory Potential of the Diet is Directly Associated with Incident Depressive Symptoms Among French Adults. J Nutr. 2019 Jul 1;149(7):1198-1207. doi: 10.1093/jn/nxz045.

name: Nutritional Epidemiology Research Team (EREN), Paris 13 University, Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory of Arts and Crafts (CNAM), COMUE Sorbonne Paris Cité, Bobigny, France

name: Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France

name: AP-HP, European Hospital Georges-Pompidou, Psychiatry and Addictology Department of the Adult and Elderly, Paris, France

name: U1266 National Institute of Health and Medical Research, Psychiatry and Neurosciences Center, Paris, France

ReferenceCitation: Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Méjean C, Andrianasolo RM, Chazelas E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ. 2019 May 29;365:l1451. doi: 10.1136/bmj.l1451.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - UFC - Université de Franche-Comté

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - UFC - Université de Franche-Comté

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

title: Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé)

ReferenceCitation: Bénard M, Bellisle F, Kesse-Guyot E, Julia C, Andreeva VA, Etilé F, Reach G, Dechelotte P, Tavolacci MP, Hercberg S, Péneau S. Impulsivity is associated with food intake, snacking, and eating disorders in a general population. Am J Clin Nutr. 2019 Jan 1;109(1):117-126. doi: 10.1093/ajcn/nqy255.

name: Nutritional Epidemiology Research Team (EREN), Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), French National Institute for Health and Medical Research (INSERM) U1153, French National Institute for Agricultural Research (INRA) U1125, National Conservatory for Arts and Crafts (CNAM), Paris 13 University, Bobigny, France

name: Paris School of Economics and INRA, UMR1393 Paris-Jourdan Economic Sciences (PjSE), Paris, France

name: Department of Endocrinology, Diabetes, and Metabolic Diseases, Avicenne Hospital, Bobigny, France

name: Nutrition Department, Rouen University Hospital and INSERM U1073, Rouen, France

name: Rouen University Hospital, Clinical Investigation Center 1404 and Normandie University, UNIROUEN, INSERM U1073, Rouen, France

title: Impulsivity is associated with food intake, snacking, and eating disorders in a general population

ReferenceCitation: Méjean C, Lampuré A, Si Hassen W, Gojard S, Péneau S, Hercberg S, Castetbon K. Influence of food preparation behaviors on 5-year weight change and obesity risk in a French prospective cohort. Int J Behav Nutr Phys Act. 2018 Nov 26;15(1):120. doi: 10.1186/s12966-018-0747-4.

ReferenceCitation: Andreeva VA, Tavolacci MP, Galan P, Ladner J, Buscail C, Péneau S, Galmiche M, Hercberg S, Déchelotte P, Julia C. Sociodemographic correlates of eating disorder subtypes among men and women in France, with a focus on age. J Epidemiol Community Health. 2019 Jan;73(1):56-64. doi: 10.1136/jech-2018-210745. Epub 2018 Oct 9.

journal_name: Journal of Epidemiology and Community Health

title: Sociodemographic correlates of eating disorder subtypes among men and women in France, with a focus on age

ReferenceCitation: Si Hassen W, Castetbon K, Péneau S, Tichit C, Nechba A, Lampuré A, Bellisle F, Hercberg S, Méjean C. Socio-economic and demographic factors associated with snacking behavior in a large sample of French adults. Int J Behav Nutr Phys Act. 2018 Mar 15;15(1):25. doi: 10.1186/s12966-018-0655-7.

title: Socio-economic and demographic factors associated with snacking behavior in a large sample of French adults

ReferenceCitation: Si Hassen W, Castetbon K, Tichit C, Péneau S, Nechba A, Ducrot P, Lampuré A, Bellisle F, Hercberg S, Méjean C. Energy, nutrient and food content of snacks in French adults. Nutr J. 2018 Feb 27;17(1):33. doi: 10.1186/s12937-018-0336-z.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Cirad

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Cirad

title: Energy, nutrient and food content of snacks in French adults

ReferenceCitation: Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Allès B, Méjean C, Deschasaux M, Fassier P, Latino-Martel P, Beslay M, Hercberg S, Lavalette C, Monteiro CA, Julia C, Touvier M. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ. 2018 Feb 14;360:k322. doi: 10.1136/bmj.k322.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - hprints.org

repository_institution: University of Oxford - Oxford Academic Notes & Queries

repositories:
HAL
PubMed Central
open-archive.highwire.org

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - hprints.org

repositories_institution: University of Oxford - Oxford Academic Notes & Queries

title: Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort


title: Phase 1 Study Evaluating the Relevance and Reliability of Gastrointestinal Temperature Measurements From a New Device (E-celsius)

acronym: e-TEMP

summary:
E-Celsius device used for measuring the gastrointestinal temperature is composed of an ingestible capsule measuring the temperature as well as a transportable module receiving data from the capsule. This device allows to measure the body temperature (± 0.2 ° C) during transit of the pill in the digestive tract to a maximum sampling frequency of 30 seconds. The main risks related to such devices are related to biocompatibility (in materials used for the capsule shell, or level of contamination of the gastrointestinal environment due to a defect in the plastic envelope the pill or a lack of hygiene, previously tested in clinical trials; see section 10.2).

It will compare conventional methods of estimating the central temperature continuously with gastrointestinal data obtained from the e-Celsius device. The main objective of the research is to validate the extent of gastrointestinal temperature obtained from the device under test consists of an ingestible electronic capsule and a data reception monitor.

Secondary objectives will be pursued:

Assess the effects of ingestion of cold drinks on temperature readings taken via e-device Celsius, esophageal probe and a rectal probe.
Explore the thermal homogeneity of the digestive tract.
Evaluate the internal memory of the capsule and its data forwarding capacity. This protocol will also measure the reliability of the measurement system while comparing it to the standards used by health staff today.

primary_purpose: Basic Science

lead_sponsor: University Hospital, Caen


title: Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients

acronym: NEOMAIT

summary: The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem cells, 2/ to correlate gut microbiota diversity and function with MAIT cell maturation and function in neonates and HSCT recipients; and 3/ to link MAIT cells and gut microbiota composition with microbial infections and severe intestinal inflammatory events in term and preterm neonates, and in HSCT recipients

ReferenceCitation: Tourret M, Talvard-Balland N, Lambert M, Ben Youssef G, Chevalier MF, Bohineust A, Yvorra T, Morin F, Azarnoush S, Lantz O, Dalle JH, Caillat-Zucman S. Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy. J Immunother Cancer. 2021 Oct;9(10). pii: e003123. doi: 10.1136/jitc-2021-003123.


title: Impact of Exercise Training on Skeletal Muscle Capillary Maturation During Angiogenesis in COPD Patients

acronym: COPDµvasc

summary:
COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation.

Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).

ReferenceCitation: Souweine JS, Gouzi F, Badia É, Pomies P, Garrigue V, Morena M, Hayot M, Mercier J, Ayoub B, Quintrec ML, Raynaud F, Cristol JP. Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation. Clin J Am Soc Nephrol. 2021 Nov;16(11):1676-1685. doi: 10.2215/CJN.02390221.

family: Souweine

full_name: Jean-Sébastien Souweine

given: Jean-Sébastien

family: Gouzi

full_name: Fares Gouzi

given: Fares

family: Badia

full_name: Éric Badia

given: Éric

family: Pomies

full_name: Pascal Pomies

given: Pascal

family: Garrigue

full_name: Valérie Garrigue

given: Valérie

family: Morena

full_name: Marion Morena

given: Marion

family: Hayot

full_name: Maurice Hayot

given: Maurice

family: Mercier

full_name: Jacques Mercier

given: Jacques

family: Ayoub

full_name: Bronia Ayoub

given: Bronia

family: Quintrec

full_name: Moglie Le Quintrec

given: Moglie Le

family: Raynaud

full_name: Fabrice Raynaud

given: Fabrice

family: Cristol

full_name: Jean-Paul Cristol

given: Jean-Paul

journal_name: Clinical Journal of the American Society of Nephrology

oa_host_type: repository

version: submittedVersion

publisher: American Society of Nephrology (ASN)

publisher_dissemination: American Society of Nephrology

publisher_group: American Society of Nephrology

publisher_normalized: American Society of Nephrology

lead_sponsor: University Hospital, Montpellier

location_facility: Department of clinical Physiology - University Hospital


title: The Anti-inflammatory Effect of Vagus Nerve Stimulation (VNS): a New Approach in the Treatment of Crohn's Disease

acronym: VNS

summary: The purpose of this study is to determine whether (VNS) Vagus Nerve Stimulation , is effective in the treatment of Crohn's disease.

ReferenceCitation: Meregnani J, Clarençon D, Vivier M, Peinnequin A, Mouret C, Sinniger V, Picq C, Job A, Canini F, Jacquier-Sarlin M, Bonaz B. Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease. Auton Neurosci. 2011 Feb 24;160(1-2):82-9. doi: 10.1016/j.autneu.2010.10.007. Epub 2010 Nov 11.

ReferenceCitation: Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000 May 25;405(6785):458-62.

lead_sponsor: University Hospital, Grenoble


title: Effects of Two Hypocaloric Diets on Weight Loss and Inflammatory Markers

summary: The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related metabolic variables.

primary_purpose: Health Services Research

ReferenceCitation: Rizkalla SW, Prifti E, Cotillard A, Pelloux V, Rouault C, Allouche R, Laromiguière M, Kong L, Darakhshan F, Massiera F, Clement K. Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. Am J Clin Nutr. 2012 Jan;95(1):49-63. doi: 10.3945/ajcn.111.017277. Epub 2011 Dec 14.

family: Rizkalla

full_name: Salwa W Rizkalla

given: Salwa W

family: Prifti

full_name: Edi Prifti

given: Edi

family: Cotillard

full_name: Aurélie Cotillard

given: Aurélie

family: Pelloux

full_name: Veronique Pelloux

given: Veronique

family: Rouault

full_name: Christine Rouault

given: Christine

family: Allouche

full_name: Reginald Allouche

given: Reginald

family: Laromiguière

full_name: Muriel Laromiguière

given: Muriel

family: Kong

full_name: LingChun Kong

given: LingChun

family: Darakhshan

full_name: Froogh Darakhshan

given: Froogh

family: Massiera

full_name: Florence Massiera

given: Florence

family: Clement

full_name: Karine Clement

given: Karine

oa_host_type: publisher

evidence: open (via free pdf)

publisher: Oxford University Press (OUP)

publisher_dissemination: Oxford University Press

publisher_group: Oxford University Press

publisher_normalized: Oxford University Press

lead_sponsor: Ceprodi S.A. Kot


title: PILOT STUDY OF GENE THERAPY FOR LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA WITH INTRATUMOURAL INJECTION OF JetPEI/DNA COMPLEXES WITH ANTITUMOURAL EFFECT AND CHEMOSENSITIZING ACTIVITY FOR GEMCITABINE

acronym: TherGAP

summary: Near 85% of patients with pancreatic adenocarcinoma are diagnosed with a locally advanced and/or metastatic unresectable tumor. In these patients chemotherapy (such as gemcitabine) is given as a palliative therapy. Aim of the present study is to evaluate the feasibility, tolerance and antitumor effect of repeated intratumoral injection of a gene therapy product (with antitumor and chemo sensitizing effects) combined with gemcitabine in patients with unresectable pancreatic carcinoma.

location_facility: Toulouse Universitary Hospital (Rangueil), Department of Gastroenterology At Rangueil Hospital

intervention_type: Genetic


title: Prospective Study Evaluating the Olfactory Recovery of Anosmia Post COVID-19 by Olfactory Rehabilitation Assisted by Web-application

acronym: COVIDANOSMIA

summary:
Anosmia is a symptom present in 40 to 80% of patients and usually only lasts 1 to 2 weeks. However, in nearly one in five patients, it can last beyond or even several months with consequences in terms of undernutrition and depression. However, olfactory rehabilitation is a technique validated in post-infectious anosmia since 2014 and recommended by international learned societies to accelerate recovery with nearly 63% improvement in anosmia In the context of the health crisis linked to the coronavirus, approximately 1 million French people will have persistent anosmia following an infection with COVID-19. A web-application to support the olfactory coaching of anosmic patients and help with follow-up seems relevant to promote recovery and the proper conduct of this coaching.

covidanosmie.fr is a web application dedicated to olfactory rehabilitation, accessible free of charge.

lead_sponsor: Weprom


title: Phase II Randomised Multicenter Trial Evaluating a Sequential Treatment With Nab-paclitaxel+Gemcitabine /FOLFIRI.3 vs Nab-paclitaxel + Gemcitabine in First Line Metastatic Pancreatic Cancer

acronym: FIRGEMAX

summary: The main objective of this trial is to evaluate every 2 months alternating nab-paclitaxel/gemcitabine and FOLFIRI.3 versus nab-paclitaxel + gemcitabine, regarding the progression of disease at 6 months.

lead_sponsor: Federation Francophone de Cancerologie Digestive

location_facility:
Centre Cario - Hpca Saint Brieuc
Clinique Tivoli Ducos
CH Pierre Benite
CHU
H Layné
CHP
CH de la Dracénie
Clinique Privée Claude Bernard
Clinique Chenieux
Hôpital Paul Brousse
Hôpitaux Drome Nord
CH Pierre Oudot
Gustave Roussy
Clinique St Jean Languedoc
CH St Jean
Hopitaux Du Leman
Centre GF Leclerc
Clinique Privée Saint Jean
Hôpital Cochin
Ch Jacques Monod
Hôpital Haut Lévèque
CHR côte de Nacre
CH
Centre François Baclesse
Clinique Privée
Clinique Pasteur Groupe ONCORAD GARONNE
Hôpital Duchenne
HEGP
Hôpital La Pitié Salpêtrière
Clinique Privée Pasteur
Hopital Europeen Marseille
Centre Hospitalier Sud Francilien


title: Diagnostic Value of Copeptin Assay for Acute Coronary Syndrome Without ST-segment Elevation

summary:
The purpose of this study is to determine whether the combination of copeptine and troponin adds diagnosis information to that provided by troponin alone or the combination of troponin and myoglobin.

Hypothesis : If the values of troponin and copeptin are not elevated, diagnosis of acute myocardial infarction can be ruled out without prolonged monitoring and serial blood sampling.

ReferenceCitation: Duchenne J, Mestres S, Dublanchet N, Combaret N, Marceau G, Caumon L, Dutoit L, Ughetto S, Motreff P, Sapin V, Schmidt J; NSTEMI Study. Diagnostic accuracy of copeptin sensitivity and specificity in patients with suspected non-ST-elevation myocardial infarction with troponin I below the 99th centile at presentation. BMJ Open. 2014 Mar 24;4(3):e004449. doi: 10.1136/bmjopen-2013-004449. Erratum in: BMJ Open. 2014;4(4):e004449corr1.

family: Duchenne

full_name: Jonathan Duchenne

given: Jonathan

family: Mestres

full_name: Stéphanie Mestres

given: Stéphanie

family: Dublanchet

full_name: Nicolas Dublanchet

given: Nicolas

family: Combaret

full_name: Nicolas Combaret

family: Marceau

full_name: Geoffroy Marceau

given: Geoffroy

family: Caumon

full_name: Laurent Caumon

given: Laurent

family: Dutoit

full_name: Laurent Dutoit

family: Ughetto

full_name: Sylvie Ughetto

given: Sylvie

family: Motreff

full_name: Pascal Motreff

given: Pascal

family: Sapin

full_name: Vincent Sapin

given: Vincent

family: Schmidt

full_name: Jeannot Schmidt

given: Jeannot

journal_name: BMJ Open

license: cc-by-nc

license_normalized: cc-by-nc

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

lead_sponsor: University Hospital, Clermont-Ferrand


title: Virtual Reality and Subjective Tinnitus

summary: The purpose of this study is to test if virtual reality immersion has the potential to significantly decrease subjective tinnitus intrusiveness when compared to standard care.

ReferenceCitation: Malinvaud D, Londero A, Niarra R, Peignard P, Warusfel O, Viaud-Delmon I, Chatellier G, Bonfils P. Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: Results of a randomized controlled trial. Hear Res. 2016 Mar;333:127-135. doi: 10.1016/j.heares.2015.12.023. Epub 2016 Jan 8.

ipd_sharing: Yes

ipd_sharing_description: Individual participant data (IPD) that underlie results in publication could be shared. IPD detailed in the protocol of a planned metaanalysis could be shared


title: COPANA - A09 PCSK 9 Substudy: Impact of Protease Inhibitors on PCSK9 Levels in Naive HIV-Infected Patients

acronym: COPANA

summary: Evaluation of the impact of initiation of protease inhibitor/ritonavir on PCSK9 levels in HIV-infected antiretroviral-naïve patients from the ANRS C09 COPANA cohort.

ReferenceCitation: Boccara F, Ghislain M, Meyer L, Goujard C, Le May C, Vigouroux C, Bastard JP, Fellahi S, Capeau J, Cohen A, Cariou B; ANRS-COPANA Study Group. Impact of protease inhibitors on circulating PCSK9 levels in HIV-infected antiretroviral-naive patients from an ongoing prospective cohort. AIDS. 2017 Nov 13;31(17):2367-2376. doi: 10.1097/QAD.0000000000001633.

family: Boccara

full_name: Franck Boccara

given: Franck

family: Ghislain

full_name: Mathilde Ghislain

given: Mathilde

family: Meyer

full_name: Laurence Meyer

given: Laurence

family: Goujard

full_name: Cecile Goujard

given: Cecile

family: May

full_name: Cedric Le May

given: Cedric Le

family: Vigouroux

full_name: Corinne Vigouroux

given: Corinne

family: Bastard

full_name: Jean P. Bastard

given: Jean P.

family: Fellahi

full_name: Soraya Fellahi

given: Soraya

family: Capeau

full_name: Jacqueline Capeau

given: Jacqueline

family: Cohen

full_name: Ariel Cohen

given: Ariel

family: Cariou

full_name: Bertrand Cariou

given: Bertrand

journal_name: AIDS

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université de Nantes

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

ipd_sharing_description: no plan to share IPD

lead_sponsor: Franck Boccara

location_facility: Cardiology Department, Saint Antoine University Hospital


title: Dose-escalation Study to Assess the Safety and Tolerability of Sub-cutaneous Injections of a Peptide-loaded Plasmacytoid Dendritic Cell Line (GeniusVac-Mel4) in Patients With Melanoma

summary: The primary objective of this study is to evaluate the safety and tolerability of multiple sub-cutaneous injections of GeniusVac-Mel4, a dendritic cell-based cancer vaccine, in patients with melanoma. The secondary objectives are to determine immune response and clinical efficacy of such injections in patients with melanoma.

ReferenceCitation: Aspord C, Leccia MT, Salameire D, Laurin D, Chaperot L, Charles J, Plumas J. HLA-A(*)0201(+) plasmacytoid dendritic cells provide a cell-based immunotherapy for melanoma patients. J Invest Dermatol. 2012 Oct;132(10):2395-2406. doi: 10.1038/jid.2012.152. Epub 2012 Jun 14.

ReferenceCitation: Aspord C, Charles J, Leccia MT, Laurin D, Richard MJ, Chaperot L, Plumas J. A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells. PLoS One. 2010 May 4;5(5):e10458. doi: 10.1371/journal.pone.0010458.


title: Insulin Resistance in Multiple System Atrophy

acronym: IRAMS

summary: Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial cytoplasmic inclusions. Some symptomatic treatments are available while disease-modification remains an unmet treatment need. Post-mortem findings suggest insulin resistance, i.e. reduced insulin signaling, in the brains of MSA patients. The aim of this study is to complete the target validation of insulin resistance for future treatment trials.

lead_sponsor: University Hospital, Bordeaux

intervention_type: Procedure


title: Safety of Autologous Adipose Derived Stroma/Stem Cells to Treat Critical Leg Ischemia.

acronym: ACELLDREAM

summary: The main purpose of this study is to evaluate the safety and feasibility of regenerative therapy with expanded adipose derived stroma/stem cells sue, administered intramuscularly in patients with critical leg ischemia.

ReferenceCitation: Planat-Benard V, Silvestre JS, Cousin B, André M, Nibbelink M, Tamarat R, Clergue M, Manneville C, Saillan-Barreau C, Duriez M, Tedgui A, Levy B, Pénicaud L, Casteilla L. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation. 2004 Feb 10;109(5):656-63. Epub 2004 Jan 20.

location_facility: University Hospital of Toulouse, Rangueil


title: Cerebral Toxoplasmosis and AIDS in the French Departments of America (DFA). Diagnostic Contribution of a PCR Assay and Genetic Diversity of Toxoplasma Gondii.

acronym: TOXODFA

summary:
With a HIV incidence much higher in the DFA than in European French territory, this disease is a major public health problem in these areas, especially in French Guiana.

Cerebral toxoplasmosis is a priority among the opportunistic infections in AIDS patients from the DFA because of its frequency (French West Indies) and of its lethality (French Guiana).

The diagnosis of cerebral toxoplasmosis may be difficult because based only on presumptive clinical and radiological features. The response to specific antitoxoplasmic therapy confirms a posteriori the diagnosis.

In reference to the data collected by the Biological Resource Centre Toxoplasma, in particular in French Guiana, we think that T. gondii strains reactivating in AIDS patients from DFA are genetically different from those reactivating in AIDS patients from Europe, with an increased capacity for dissemination via peripheral blood in the first ones. This more frequent or more prolonged parasitemia could facilitate the diagnosis of cerebral toxoplasmosis by PCR test from peripheral blood samples in AIDS patients from the French departments of America.

ReferenceCitation: Ajzenberg D, Lamaury I, Demar M, Vautrin C, Cabié A, Simon S, Nicolas M, Desbois-Nogard N, Boukhari R, Riahi H, Dardé ML, Massip P, Dupon M, Preux PM, Labrunie A, Boncoeur MP. Performance Testing of PCR Assay in Blood Samples for the Diagnosis of Toxoplasmic Encephalitis in AIDS Patients from the French Departments of America and Genetic Diversity of Toxoplasma gondii: A Prospective and Multicentric Study. PLoS Negl Trop Dis. 2016 Jun 29;10(6):e0004790. doi: 10.1371/journal.pntd.0004790. eCollection 2016 Jun.

family: Ajzenberg

full_name: Daniel Ajzenberg

given: Daniel

family: Lamaury

full_name: Isabelle Lamaury

given: Isabelle

family: Demar

full_name: Magalie Demar

given: Magalie

family: Vautrin

full_name: Cyrille Vautrin

given: Cyrille

family: Cabié

full_name: André Cabié

given: André

family: Simon

full_name: Stéphane Simon

given: Stéphane

family: Nicolas

full_name: Muriel Nicolas

given: Muriel

family: Desbois-Nogard

full_name: Nicole Desbois-Nogard

given: Nicole

family: Boukhari

full_name: Rachida Boukhari

given: Rachida

family: Riahi

full_name: Homayoun Riahi

given: Homayoun

family: Dardé

full_name: Marie-Laure Dardé

given: Marie-Laure

family: Massip

full_name: Patrice Massip

given: Patrice

family: Dupon

full_name: Michel Dupon

given: Michel

family: Preux

full_name: Pierre-Marie Preux

given: Pierre-Marie

family: Labrunie

full_name: Anaïs Labrunie

given: Anaïs

family: Boncoeur

full_name: Marie-Paule Boncoeur

given: Marie-Paule

currency_apc_doaj: USD

journal_name: PLOS Neglected Tropical Diseases

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université de Limoges

repositories:
HAL
PubMed Central
pdfs.semanticscholar.org

location_facility: Service des Maladies Infectieuses - CHU de Pointe à Pitre

location_facility: Maladies Infectieuses et Tropicales - CH Andrée Rosemon

location_facility: Services Maladies Infectieuses et Tropicales- CHU Fort-de-France

location_facility: Dermatologie et CISIH- CH Andrée Rosemon


ReferenceCitation: Remontet L, Estève J, Bouvier AM, Grosclaude P, Launoy G, Menegoz F, Exbrayat C, Tretare B, Carli PM, Guizard AV, Troussard X, Bercelli P, Colonna M, Halna JM, Hedelin G, Macé-Lesec'h J, Peng J, Buemi A, Velten M, Jougla E, Arveux P, Le Bodic L, Michel E, Sauvage M, Schvartz C, Faivre J. Cancer incidence and mortality in France over the period 1978-2000. Rev Epidemiol Sante Publique. 2003 Feb;51(1 Pt 1):3-30.

ReferenceCitation: Ménégoz F, Black RJ, Arveux P, Magne V, Ferlay J, Buémi A, Carli PM, Chapelain G, Faivre J, Gignoux M, Grosclaude P, Mace-Lesec'h J, Raverdy N, Schaffer P. Cancer incidence and mortality in France in 1975-95. Eur J Cancer Prev. 1997 Oct;6(5):442-66.

ReferenceCitation: Coleman MP. Trends in breast cancer incidence, survival, and mortality. Lancet. 2000 Aug 12;356(9229):590-1; author reply 593. Erratum in: Lancet 2000 Aug 26;356(9231):774.

ReferenceCitation: Breast International Group (BIG) 1-98 Collaborative Group, Thürlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Rabaglio M, Smith I, Wardley A, Price KN, Goldhirsch A. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med. 2005 Dec 29;353(26):2747-57. Erratum in: N Engl J Med. 2006 May 18;354(20):2200. Wardly, Andrew [corrected to Wardley, Andrew ].

ReferenceCitation: Finck G, Barton DL, Loprinzi CL, Quella SK, Sloan JA. Definitions of hot flashes in breast cancer survivors. J Pain Symptom Manage. 1998 Nov;16(5):327-33.

ReferenceCitation: Stearns V, Ullmer L, López JF, Smith Y, Isaacs C, Hayes D. Hot flushes. Lancet. 2002 Dec 7;360(9348):1851-61. Review.

ReferenceCitation: Couzi RJ, Helzlsouer KJ, Fetting JH. Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol. 1995 Nov;13(11):2737-44.

ReferenceCitation: Fellowes D, Fallowfield LJ, Saunders CM, Houghton J. Tolerability of hormone therapies for breast cancer: how informative are documented symptom profiles in medical notes for 'well-tolerated' treatments? Breast Cancer Res Treat. 2001 Mar;66(1):73-81.

ReferenceCitation: Lower EE, Blau R, Gazder P, Tummala R. The risk of premature menopause induced by chemotherapy for early breast cancer. J Womens Health Gend Based Med. 1999 Sep;8(7):949-54.

ReferenceCitation: McPhail G, Smith LN. Acute menopause symptoms during adjuvant systemic treatment for breast cancer: a case-control study. Cancer Nurs. 2000 Dec;23(6):430-43.

ReferenceCitation: Loprinzi CL, Zahasky KM, Sloan JA, Novotny PJ, Quella SK. Tamoxifen-induced hot flashes. Clin Breast Cancer. 2000 Apr;1(1):52-6.

ReferenceCitation: Love RR, Cameron L, Connell BL, Leventhal H. Symptoms associated with tamoxifen treatment in postmenopausal women. Arch Intern Med. 1991 Sep;151(9):1842-7.

ReferenceCitation: Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, Jonas WB. Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet. 1997 Sep 20;350(9081):834-43. Erratum in: Lancet 1998 Jan 17;351(9097):220.

ReferenceCitation: Jonas WB, Kaptchuk TJ, Linde K. A critical overview of homeopathy. Ann Intern Med. 2003 Mar 4;138(5):393-9. Review.

ReferenceCitation: Cucherat M, Haugh MC, Gooch M, Boissel JP. Evidence of clinical efficacy of homeopathy. A meta-analysis of clinical trials. HMRAG. Homeopathic Medicines Research Advisory Group. Eur J Clin Pharmacol. 2000 Apr;56(1):27-33.

ReferenceCitation: Jonas WB. Researching alternative medicine. Nat Med. 1997 Aug;3(8):824-7.

ReferenceCitation: Guyatt GH, Sackett DL, Cook DJ. Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA. 1993 Dec 1;270(21):2598-601.

ReferenceCitation: Grol R, Grimshaw J. Evidence-based implementation of evidence-based medicine. Jt Comm J Qual Improv. 1999 Oct;25(10):503-13.

ReferenceCitation: Barnes J, Ernst E. Complementary medicine. Br J Gen Pract. 1997 May;47(418):329.

ReferenceCitation: Clover A, Ratsey D. Homeopathic treatment of hot flushes: a pilot study. Homeopathy. 2002 Apr;91(2):75-9.

ReferenceCitation: Thompson EA, Reilly D. The homeopathic approach to the treatment of symptoms of oestrogen withdrawal in breast cancer patients. A prospective observational study. Homeopathy. 2003 Jul;92(3):131-4.

ReferenceCitation: Thompson EA, Montgomery A, Douglas D, Reilly D. A pilot, randomized, double-blinded, placebo-controlled trial of individualized homeopathy for symptoms of estrogen withdrawal in breast-cancer survivors. J Altern Complement Med. 2005 Feb;11(1):13-20.

ReferenceCitation: Relton C, Weatherley-Jones E. Homeopathy service in a National Health Service community menopause clinic: audit of clinical outcomes. J Br Menopause Soc. 2005 Jun;11(2):72-3.

ReferenceCitation: Bordet MF, Colas A, Marijnen P, Masson J, Trichard M. Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study. Homeopathy. 2008 Jan;97(1):10-5. doi: 10.1016/j.homp.2007.11.005.

ReferenceCitation: Sloan JA, Loprinzi CL, Novotny PJ, Barton DL, Lavasseur BI, Windschitl H. Methodologic lessons learned from hot flash studies. J Clin Oncol. 2001 Dec 1;19(23):4280-90.

ReferenceCitation: Heudel PE, Van Praagh-Doreau I, Duvert B, Cauvin I, Hardy-Bessard AC, Jacquin JP, Stefani L, Vincent L, Dramais D, Guastalla JP, Blanc E, Belleville A, Lavergne E, Pérol D. Does a homeopathic medicine reduce hot flushes induced by adjuvant endocrine therapy in localized breast cancer patients? A multicenter randomized placebo-controlled phase III trial. Support Care Cancer. 2019 May;27(5):1879-1889. doi: 10.1007/s00520-018-4449-x. Epub 2018 Sep 7.

family: Heudel

full_name: Pierre-Etienne Heudel

given: Pierre-Etienne

family: Van Praagh-Doreau

full_name: Isabelle Van Praagh-Doreau

family: Duvert

full_name: Bernard Duvert

given: Bernard

family: Cauvin

full_name: Isabelle Cauvin

family: Hardy-Bessard

full_name: Anne-Claire Hardy-Bessard

given: Anne-Claire

family: Jacquin

full_name: Jean-Philippe Jacquin

given: Jean-Philippe

family: Stefani

full_name: Laetitia Stefani

given: Laetitia

family: Vincent

full_name: Lionel Vincent

given: Lionel

family: Dramais

full_name: Dominique Dramais

given: Dominique

family: Guastalla

full_name: Jean-Paul Guastalla

given: Jean-Paul

family: Blanc

full_name: Ellen Blanc

given: Ellen

family: Belleville

full_name: Aurélie Belleville

given: Aurélie

family: Lavergne

full_name: Emilie Lavergne

given: Emilie

family: Pérol

full_name: David Pérol

given: David

journal_name: Supportive Care in Cancer

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

lead_sponsor: Centre Leon Berard

acronym: HBC

location_facility: Institut de Cancérologie Lucien Neuwirth

title: Placebo-controlled Evaluation of the Homeopathic Drug BRN01 for the Treatment of Hot Flashes in Women With Non Metastatic Breast Cancer Treated by Adjuvant Hormonal Therapy

summary: The purpose of this study is to evaluate the efficacy of a homeopathic treatment (BRN01) in reducing hot flash scores after 4 weeks of treatment.


type: Other Grant/Funding Number

title: Soluble Neprilysin, NT-proBNP, and Growth-Differentiation-Factor-15 as Biomarkers for Heart Failure in Dialysis Patients

acronym: SONGBIRD

summary:
Objectives: The aim of this study is to determine whether growth differentiation factor-15 (GDF15) and circulating neprilysin (cNEP) improve the diagnosis of congestive heart failure (HF) in patients on dialysis.

Background: Dialysis patients are at increased risk of HF. However, diagnostic utility of NT-proBNP as a biomarker is decreased in patients on dialysis. GDF15 and cNEP are biomarkers of distinct mechanisms that may contribute to HF pathophysiology in such cohorts.

Methods: We compare circulating concentrations of NT-proBNP, GDF15, and cNEP along with NEP activity in patients on chronic dialysis without and with HF, as diagnosed by clinical parameters and post-dialysis echocardiography. We use correlation, linear and logistic regression as well as receiver operating characteristic (ROC) analyses.

time_perspective: Cross-Sectional

lead_sponsor: Hannover Medical School

location_country: Germany France

location_facility:
Inserm Umr S-942
Hannover Medical School

intervention_type: Diagnostic Test


title: Diffusion-Weighted Magnetic Resonance Imaging Assessment of Liver Metastasis to Improve Surgical Planning

acronym: DREAM

summary: The DREAM study will assess the diagnostic accuracy of diffusion-weighted MRI in combination with other imaging modalities (multiparametric MRI and CT Scan) in determining the true status of disappearing liver metastasis (DLM) detected after conversion systemic therapy for unresectable or borderline resectable colorectal liver metastasis (CRLM).

status: Active, not recruiting

lead_sponsor: European Organisation for Research and Treatment of Cancer - EORTC

location_country:
Austria
France
Japan
Belgium
United States

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: Niigata Prefectural Cancer Center Hospital

location_facility: Osaka Medical Center for Cancer and Cardiovascular Diseases

location_facility: Jichi Medical University Saitama Medical Center


title: Protocole Evaluant Chez Des Patients Porteurs de Cancers Colorectaux Metastatiques l'Interet Des Determinants Genotypiques Pour l'Optimisation de l'Efficacite et de la Tolerance de la Chimiotherapie Par Irinotecan et 5-fluorouracile

summary:
This study intends to optimize a fluorouracil/irinotecan chemotherapy regimen by the identification of individual thymidylate synthase (TS) and UDP-glucuronosyltransferase 1 (UGT1A1) polymorphisms before the first administration.

The results of this identification determine the chemotherapy type: high-dose irinotecan or not.

ReferenceCitation: Iyer L, Das S, Janisch L, Wen M, Ramírez J, Karrison T, Fleming GF, Vokes EE, Schilsky RL, Ratain MJ. UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J. 2002;2(1):43-7.

lead_sponsor: Institut de Recherche Clinique sur les Cancers et le Sang

location_facility:
Department of Oncology - CHLS
Department of Oncology, CHU
Department of Oncology, IPC
Institut Claudius Regaud
Department of Oncology, ICL
Department of Gastroenterology, CHLS


title: Secondary Prevention of Atrial Fibrillation With an Alpha-Linolenic Enriched Diet : a Randomized Study

summary:
An alpha linolenic acid (ALA) rich diet in the Lyon Diet Heart Study reduced sudden cardiac deaths possibly by reducing cardiac arrhythmias and ventricular fibrillation (Lancet 1994).

Since then, there has been a growing interest in ALA, ω-3 fatty acid family precursor, as a cardioprotective nutrient. Much of the interest has focused on the potential antiarrhythmic effect of longer chain ω-3 fatty acids, DHA and EPA, derived from fish.

We therefore concluded it important to test wether vegetable source ω-3 also had antiarrhythmic effects, as shown in animals by Leaf and McLennan, since this might also explain the beneficial effects seen on cardiovascular mortality in the Lyon Diet Heart Study.

primary_purpose: Prevention

ReferenceCitation: de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994 Jun 11;343(8911):1454-9. Erratum in: Lancet 1995 Mar 18;345(8951):738.

ReferenceCitation: Renaud S, de Lorgeril M, Delaye J, Guidollet J, Jacquard F, Mamelle N, Martin JL, Monjaud I, Salen P, Toubol P. Cretan Mediterranean diet for prevention of coronary heart disease. Am J Clin Nutr. 1995 Jun;61(6 Suppl):1360S-1367S. doi: 10.1093/ajcn/61.6.1360S.

ReferenceCitation: Renaud S, Nordøy A. "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. Lancet. 1983 May 21;1(8334):1169.

ReferenceCitation: Lanzmann-Petithory D, Pueyo S, Renaud S. Primary prevention of cardiovascular diseases by alpha-linolenic acid. Am J Clin Nutr. 2002 Dec;76(6):1456; author reply 1456-7. doi: 10.1093/ajcn/76.6.1456.

ReferenceCitation: Renaud SC, Lanzmann-Petithory D. alpha-linolenic acid in the prevention of cardiovascular diseases. World Rev Nutr Diet. 2001;88:79-85. Review.

ReferenceCitation: Renaud SC, Lanzmann-Petithory D. The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. Am J Clin Nutr. 2002 Oct;76(4):903-4; author reply 904-6.

ReferenceCitation: Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, Manor O, Pella D, Berry EM. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet. 2002 Nov 9;360(9344):1455-61.

ReferenceCitation: Lanzmann-Petithory D. Alpha-linolenic acid and cardiovascular diseases. J Nutr Health Aging. 2001;5(3):179-83. Review.

ReferenceCitation: Kang JX, Leaf A. Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes. Eur J Pharmacol. 1996 Feb 15;297(1-2):97-106.

ReferenceCitation: McLennan PL, Dallimore JA. Dietary canola oil modifies myocardial fatty acids and inhibits cardiac arrhythmias in rats. J Nutr. 1995 Apr;125(4):1003-9.

location_facility:
Hôpital du Haut-Lévêque
Robert Boulin Hospital
Girac Hospital

intervention_type: Behavioral


title: Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

acronym: HCM

summary: Fibrosis, myocardial deformation and biomarkers in hypertrophic cardiomyopathy (HCM)

lead_sponsor: Nantes University Hospital


title: Early Detection and Prediction of Cardiotoxicity in Radiotherapy-treated Breast Cancer Patients

acronym: BACCARAT

summary: Breast radiotherapy RT used until the 1990s was clearly responsible for increased mortality due to long term cardiac complications. Since the 2000s, improvements have appeared in dose distributions to organ at risks such as heart, but now, little is known on the risk of potential cardiac impairment in this population, in particular for chemotherapy naive patients. Based on the state that clinically detectable cardiotoxicity is generally preceded by subclinical cardiac dysfunctions, the aim of the BACCARAT study (BreAst Cancer and Cardiotoxicity induced by RAdioTherapy) is to evaluate whether adjuvant 3DCRT induces cardiac toxicity that could be detected in the first two years after treatment based on a global approach with repeated analysis of subclinical functional and anatomical cardiac lesions in myocardial and coronary levels and circulating biomarkers.

status: Unknown status

primary_purpose: Screening

ReferenceCitation: Walker V, Lairez O, Fondard O, Jimenez G, Camilleri J, Panh L, Broggio D, Bernier MO, Laurier D, Ferrières J, Jacob S. Myocardial deformation after radiotherapy: a layer-specific and territorial longitudinal strain analysis in a cohort of left-sided breast cancer patients (BACCARAT study). Radiat Oncol. 2020 Aug 20;15(1):201. doi: 10.1186/s13014-020-01635-y.

family: Walker

full_name: Valentin Walker

given: Valentin

family: Lairez

full_name: Olivier Lairez

given: Olivier

family: Fondard

full_name: Olivier Fondard

family: Jimenez

full_name: Gaëlle Jimenez

given: Gaëlle

family: Camilleri

full_name: Jérémy Camilleri

given: Jérémy

family: Panh

full_name: Loïc Panh

given: Loïc

family: Broggio

full_name: David Broggio

family: Bernier

full_name: Marie-Odile Bernier

given: Marie-Odile

family: Laurier

full_name: Dominique Laurier

family: Ferrières

full_name: Jean Ferrières

given: Jean

family: Jacob

full_name: Sophie Jacob

given: Sophie

journal_name: Radiation Oncology

repositories:
HAL
PubMed Central

ReferenceCitation: Walker V, Lairez O, Fondard O, Pathak A, Pinel B, Chevelle C, Franck D, Jimenez G, Camilleri J, Panh L, Broggio D, Derreumaux S, Bernier MO, Laurier D, Ferrières J, Jacob S. Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study). Radiat Oncol. 2019 Nov 14;14(1):204. doi: 10.1186/s13014-019-1408-8.

family: Pathak

ReferenceCitation: Jacob S, Camilleri J, Derreumaux S, Walker V, Lairez O, Lapeyre M, Bruguière E, Pathak A, Bernier MO, Laurier D, Ferrieres J, Gallocher O, Latorzeff I, Pinel B, Franck D, Chevelle C, Jimenez G, Broggio D. Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study). Radiat Oncol. 2019 Feb 7;14(1):29. doi: 10.1186/s13014-019-1234-z.

ReferenceCitation: Jacob S, Pathak A, Franck D, Latorzeff I, Jimenez G, Fondard O, Lapeyre M, Colombier D, Bruguiere E, Lairez O, Fontenel B, Milliat F, Tamarat R, Broggio D, Derreumaux S, Ducassou M, Ferrières J, Laurier D, Benderitter M, Bernier MO. Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study. Radiat Oncol. 2016 Apr 7;11:54. doi: 10.1186/s13014-016-0627-5.


type: Other Identifier

title: Efficiency of rTMS in Bulimia: a Controlled Randomized Study

acronym: rTMS&bulimia

summary:
Bulimia nervosa is defined by recurrent episodes of binge eating followed by compensatory behaviors (such as induced vomiting) to prevent weight gain. It is a common and serious disease for which current treatment strategies have to be improved.

The aim of this study is to assess whether a transcranial magnetic stimulation reduces bulimic symptoms in a short term.

ReferenceCitation: Van den Eynde F, Guillaume S, Broadbent H, Campbell IC, Schmidt U. Repetitive transcranial magnetic stimulation in anorexia nervosa: a pilot study. Eur Psychiatry. 2013 Feb;28(2):98-101. doi: 10.1016/j.eurpsy.2011.06.002. Epub 2011 Aug 30.

family: Van den Eynde

full_name: F. Van den Eynde

given: F.

family: Guillaume

full_name: S. Guillaume

given: S.

family: Broadbent

full_name: H. Broadbent

given: H.

family: Campbell

full_name: I.C. Campbell

family: Schmidt

full_name: U. Schmidt

given: U.

journal_name: European Psychiatry

publisher: Cambridge University Press (CUP)

publisher_dissemination: Cambridge University Press

publisher_group: Cambridge University Press

publisher_normalized: Cambridge University Press

title: Repetitive Transcranial Magnetic Stimulation in Anorexia Nervosa: a Pilot Study

ReferenceCitation: Van den Eynde F, Broadbent H, Guillaume S, Claudino A, Campbell IC, Schmidt U. Handedness, repetitive transcranial magnetic stimulation and bulimic disorders. Eur Psychiatry. 2012 May;27(4):290-3. doi: 10.1016/j.eurpsy.2010.08.015. Epub 2010 Nov 9.

family: Claudino

full_name: A. Claudino

given: A.

ReferenceCitation: Guillaume S, Gay A, Jaussent I, Sigaud T, Billard S, Attal J, Seneque M, Galusca B, Thiebaut S, Massoubre C, Courtet P. Improving decision-making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study. Int J Eat Disord. 2018 Sep;51(9):1103-1106. doi: 10.1002/eat.22942. Epub 2018 Sep 21.

name: Department of Psychiatric Emergency and Acute Care; Lapeyronie Hospital, CHRU Montpellier; Montpellier France

name: INSERM U1088; University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research; Montpellier France

full_name: Sebastien Guillaume

given: Sebastien

name: University Hospital of St-Etienne; Department of Psychiatry and Addictology, North Hospital; St Etienne France

name: TAPE Research Team; Jean Monnet University; Saint Etienne France

family: Gay

full_name: Aurélia Gay

given: Aurélia

family: Jaussent

full_name: Isabelle Jaussent

given: Isabelle

family: Sigaud

full_name: Torrance Sigaud

given: Torrance

name: Department of Addictology; Quimper France

family: Billard

full_name: Stephane Billard

given: Stephane

name: University Department of Adult Psychiatry, CHU Montpellier; Montpellier France

family: Attal

full_name: Jerome Attal

given: Jerome

family: Seneque

full_name: Maude Seneque

given: Maude

family: Galusca

journal_name: International Journal of Eating Disorders


title: Impact du Vieillissement (VI) Sur le Compartiment Circulant et Sur la Mobilisation (MO) Des progéniteurs endothéliaux (PE) Par ischémie Locale (IL) : étude Pilote

acronym: VIMOPEIL

summary: This part of the project aims to describe changes in markers of vascular competence (Endothelial Microparticles Platelet (EMP), Circulating endothelial cells (CEC) and Circulating endothelial progenitors (EPC)) at different ages of lifespan both in physiological state and in response to hypoxia-induced vascular stress.

ReferenceCitation: HoWangYin KY, Loinard C, Bakker W, Guérin CL, Vilar J, d'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy BI, Pouysségur J, Smadja DM, Silvestre JS. HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia. Stem Cells. 2014 Jan;32(1):231-43. doi: 10.1002/stem.1540. Erratum in: Stem Cells. 2014 Apr;32(4):1055-7. D'Audigier, Clément [corrected to d'Audigier, Clément].

name: INSERM UMRS 970; Fontenay aux Roses France

family: HoWangYin

full_name: Kiave-Yune HoWangYin

given: Kiave-Yune

name: Institut de Radioprotection et de Sureté Nucléaire; Fontenay aux Roses France

family: Loinard

full_name: Céline Loinard

given: Céline

family: Bakker

full_name: Wineke Bakker

given: Wineke

family: Guérin

full_name: Coralie L. Guérin

given: Coralie L.

family: Vilar

full_name: José Vilar

given: José

name: INSERM UMRS 765; Université Paris Descartes; Sorbonne Paris Cité Paris France

name: AP-HP; Hôpital Européen Georges Pompidou; Service d'hématologie Biologique Paris France

family: D'Audigier

full_name: Clément D'Audigier

given: Clément

family: Mauge

full_name: Laetitia Mauge

given: Laetitia

name: AP-HP; Hôpital Européen Georges Pompidou; Service d'anatomie Pathologique Paris France

family: Bruneval

full_name: Patrick Bruneval

given: Patrick

family: Emmerich

full_name: Joseph Emmerich

given: Joseph

family: Lévy

full_name: Bernard I. Lévy

given: Bernard I.

name: University of Nice, Institute of Research on Cancer & Aging (IRCAN)Centre A. Lacassagne, Nice, France and Centre Scientifique de Monaco

family: Pouysségur

full_name: Jacques Pouysségur

given: Jacques

family: Smadja

full_name: David M. Smadja

given: David M.

family: Silvestre

full_name: Jean-Sébastien Silvestre

given: Jean-Sébastien

bso_classification: Biology (fond.)

journal_name: STEM CELLS

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

title: HIF-Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell-Based Therapies for the Treatment of Critical Limb Ischemia

ReferenceCitation: Evrard SM, d'Audigier C, Mauge L, Israël-Biet D, Guerin CL, Bieche I, Kovacic JC, Fischer AM, Gaussem P, Smadja DM. The profibrotic cytokine transforming growth factor-β1 increases endothelial progenitor cell angiogenic properties. J Thromb Haemost. 2012 Apr;10(4):670-9. doi: 10.1111/j.1538-7836.2012.04644.x.

family: EVRARD

full_name: S. M. EVRARD

given: S. M.

family: D′AUDIGIER

full_name: C. D′AUDIGIER

given: C.

family: MAUGE

full_name: L. MAUGE

given: L.

family: ISRAËL-BIET

full_name: D. ISRAËL-BIET

given: D.

family: GUERIN

full_name: C. L. GUERIN

given: C. L.

family: BIECHE

full_name: I. BIECHE

given: I.

family: KOVACIC

full_name: J. C. KOVACIC


title: Chronic Micro-inflammation and Bone and Muscular Status in Elderly

acronym: Compalimage

summary: This project aims to assess the impact of chronic micro-inflammation on age-related loss of muscle (sarcopenia) and bone (osteopenia). The hypothesis is that chronic micro-inflammation and oxidative stress, which prevalence increases during ageing, may participate in the pathogenesis of both sarcopenia and osteopenia.


title: A Phase 2 Study of Aflibercept and Chemotherapy as First Line Treatment for Metastatic Colorectal Cancer Assessable With DCE-US.

acronym: PULSAR

summary: The PULSAR trial is an international, investigator-initiated, single arm open-label phase II study. The aim of this study is to measure the clinical activity of the combination FOLFIRI-aflibercept in an homogeneous group of patients with metastatic colorectal cancer, and treated with a FOLFIRI-aflibercept regimen as first line treatment.

lead_sponsor: Centre Oscar Lambret

location_facility:
Centre Oscar Lambret
Kremlin Bicetre
Centre Georges François Leclerc
Institut Paoli Calmettes
CHRU
Institut Bergonié
Hôpital Universitaire Paul Brousse
Gustave Roussy


title: A French, Multicenter, Prospective, Observational, "Real Life" Assessment of the Safety and Efficacy of the Low Profile Visualized Intraluminal Support (LVIS and LVIS JR) Devices in the Treatment of Intracranial Aneurysms

summary: A French, multicenter, prospective, observational, "real life" assessment of the safety and efficacy of LVIS and LVIS JR devices in the treatment of intracranial aneurysms

lead_sponsor: Microvention-Terumo, Inc.

location_facility: Hôpital d'instruction des Armées Saint-Anne


title: A Phase II Study Evaluating the Non-inferiority and Better Tolerability of the Device PHOS-ISTOS Compared to the Conventional Photodynamic Therapy (PDT)

acronym: PHOS-ISTOS

summary: This study aims to compare the efficacy and tolerance of a new photodynamic therapy device (PHOS-ISTOS) with the conventional PDT device (Aktilite®) for the treatment of actinic keratosis of the scalp

ReferenceCitation: Vignion-Dewalle AS, Abi Rached H, Thecua E, Lecomte F, Deleporte P, Béhal H, Hommel T, Duhamel A, Szeimies RM, Mortier L, Mordon S. A New Light-Emitting, Fabric-Based Device for Photodynamic Therapy of Actinic Keratosis: Protocol for a Randomized, Controlled, Multicenter, Intra-Individual, Phase II Noninferiority Study (the Phosistos Study). JMIR Res Protoc. 2019 Apr 26;8(4):e12990. doi: 10.2196/12990.

apc_source: openAPC

family: Vignion-Dewalle

full_name: Anne-Sophie Vignion-Dewalle

given: Anne-Sophie

family: Abi Rached

full_name: Henry Abi Rached

given: Henry

family: Thecua

full_name: Elise Thecua

given: Elise

family: Lecomte

full_name: Fabienne Lecomte

given: Fabienne

family: Deleporte

full_name: Pascal Deleporte

given: Pascal

family: Béhal

full_name: Hélène Béhal

given: Hélène

family: Hommel

full_name: Theresa Hommel

given: Theresa

family: Duhamel

full_name: Alain Duhamel

given: Alain

family: Szeimies

full_name: Rolf-Markus Szeimies

given: Rolf-Markus

family: Mortier

full_name: Laurent Mortier

given: Laurent

family: Mordon

full_name: Serge Mordon

given: Serge

journal_name: JMIR Research Protocols

repository_institution: PubMed Central - Europe PMC

repository_institution: Université de Lille (University Of Lille) - LillOA

repository_normalized: LillOA (Lille Open Archive)

repositories:
HAL
LillOA (Lille Open Archive)
PubMed Central

publisher: JMIR Publications Inc.

publisher_dissemination: JMIR Publications

publisher_group: JMIR Publications

publisher_normalized: JMIR Publications

location_facility:
CHRU, Hôpital Claude Huriez
Klinikum Vest Gmbh


lead_sponsor: University Hospital, Lille

location_country: Belgium France

acronym: DOSINDYGO

location_facility: Hôpital Erasme, Clinique Universitaire de Bruxelles

title: A Multi-center Phase II Study With Light Dose Escalation During Intraoperative Photodynamic Therapy of Glioblastoma

summary: The phase II study evaluate a light dose escalation in a classical intraoperative PDT regimen mediated by 5-ALA-PpIX, in glioblastoma patients with access to full surgical removal of the contrast enhancement. This treatment will be performed in addition to the current reference treatment of glioblastoma: maximum removal surgery followed by radiochemotherapy according to the Stupp protocol.


title: Evaluation of Intermittent Pneumatic Compression Associated With Elastic Stockings and Anticoagulant Prophylaxis Versus Anticoagulant Prophylaxis Alone on Venous Thromboembolism Incidence in ICU Patients Without High Risk of Bleeding

summary: This multicentre open-label randomized parallel-group trial aims to compare the association of intermittent pneumatic compression of the lower limbs + elastic stockings + anticoagulant prophylaxis to anticoagulant prophylaxis alone on the incidence of venous thromboembolism systematically evaluated at day 6, in patients hospitalized in intensive care units and without high bleeding risk.

lead_sponsor: University Hospital, Brest

location_country: Monaco France

location_facility:
CH d'Angoulême
CHU de Dijon
CHU d'Angers
HIA Clermont-Tonnerre
CH de Morlaix
CH de Quimper
CH Monaco
Medical Intensive Care Unit
CH de Corbeil Essonne
CHU de Poitiers
CHU de Tours
CH Montauban
CH de St Malo


title: Evaluation of Intermittent Pneumatic Compression (IPC) of the Lower Limbs Associated With Elastic Stockings (ES) Compared to ES Alone on Venous Thromboembolism Incidence in Patients With High Bleeding Risk Hospitalized in Intensive Medical Care Units

summary: This multicentre open-label randomized parallel-group trial aims to evaluate the association intermittent pneumatic compression + elastick stockings versus elasting stockings alone on symptomatic or asymptomatic venous thromboembolism incidence, evaluated systematically at day 6 (+/-2days), in patients hospitalized in intensive care units and with high bleeding risk.

location_facility:
Medical intensive care unit
HIA Clermont-Tonnerre
Intensive Care Unit
Medical Intensive Care Unit


title: Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes

acronym: STOP

summary:
Ankylosing spondylitis (AS) is a frequent chronic inflammatory rheumatic disease that affects the axial skeleton, starting in the sacroiliac joints and spreading to the spine in most patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for AS. Even if the use of anti-TNF agents has demonstrated good clinical efficacy in controlling inflammation, in contrast to other conditions such as rheumatoid arthritis and psoriatic arthritis, anti-TNF treatment has failed to demonstrate any benefit on the structural progression of AS, some data even suggesting that it may accelerate the formation of syndesmophytes that seems to be an independent process of TNF. Conversely, NSAIDs inhibit ossification phenomena independently of their anti-inflammatory properties, owing to a specific action on bone formation via prostaglandin inhibition.

Several features suggest that a continuous NSAID therapy is needed, in addition to anti-TNF treatment, to prevent syndesmophyte formation in AS patients.

location_facility: service de rhumatologie - AP-HP - Hôpital Ambroise Paré

location_facility: Service de Rhumatologie - CHU de Bordeaux

location_facility: service de rhumatologie - CHU de Strasbourg

location_facility: service de rhumatologie - AP-HP- Hôpital La Pitié Salpétrière

location_facility: service de Rhumatologie - CH Princesse Grace

location_facility: service de rhumatologie - CHU de Limoges

location_facility: Service de rhumatologie - AP-HP - Hôpital Lariboisière

location_facility: service de rhumatologie - CHU de Saint-Etienne

location_facility: service de rhumatologie - CHU de Toulouse

location_facility: Service de rhumatologie - CHU de Besançon

location_facility: service de rhumatologie - CHU de Montpellier

location_facility: service de rhumatologie - AP-HP - Hôpital Henri Mondor