title: Efficacy and Tolerance of EGb 761® 120mg Two Times a Day on Dementia of Alzheimer Type's Onset in Patients Suffering From Memory Complaints. A Randomised, Double-blind, Multicentre, Parallel Groups, Placebo Controlled Phase IIIb/IV Study in Elderly Over 70

summary: The purpose of this study is to determine whether Tanakan® is effective at slowing the progression from memory complaint to dementia of Alzheimer's type.

ReferenceCitation: Vellas B, Coley N, Ousset PJ, Berrut G, Dartigues JF, Dubois B, Grandjean H, Pasquier F, Piette F, Robert P, Touchon J, Garnier P, Mathiex-Fortunet H, Andrieu S; GuidAge Study Group. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol. 2012 Oct;11(10):851-9. doi: 10.1016/S1474-4422(12)70206-5. Epub 2012 Sep 6. Review.

family: Vellas

full_name: Bruno Vellas

given: Bruno

family: Coley

full_name: Nicola Coley

given: Nicola

family: Ousset

full_name: Pierre-Jean Ousset

given: Pierre-Jean

family: Berrut

full_name: Gilles Berrut

family: Dartigues

full_name: Jean-François Dartigues

given: Jean-François

family: Dubois

full_name: Bruno Dubois

family: Grandjean

full_name: Hélène Grandjean

given: Hélène

family: Pasquier

full_name: Florence Pasquier

given: Florence

family: Piette

full_name: François Piette

given: François

family: Robert

full_name: Philippe Robert

given: Philippe

family: Touchon

full_name: Jacques Touchon

given: Jacques

family: Garnier

full_name: Philippe Garnier

family: Mathiex-Fortunet

full_name: Hélène Mathiex-Fortunet

family: Andrieu

full_name: Sandrine Andrieu

given: Sandrine

journal_name: The Lancet Neurology

title: Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

lead_sponsor: Ipsen

location_facility: 117, avenue du Maréchal de Lattre de Tassigny

location_facility: 136 av. Ambroise Croizat Saint Martin d'Heres

location_facility: Centre Hospitalier Universitaire Hotel Dieu Gerontologie Clinique 4 rue Larrey

location_facility: 22 avenue du Général Leclerc Les Bougainvillées

location_facility: Centre Commercial La Verriere place Beauval

location_facility: Hopital Roger Salengro Service de Neurologie C rue Emile Laine

location_facility: Centre Hospitalier Jacques Coeur Hôpital Taillegrain

location_facility: 1 rue Franz Schubert Saint Martin d'Hères

location_facility: Centre Raymond Ruffi 12 rue Alexandre Ducros

location_facility: Residence le Paradis Bat 17, 74-78 rue Volney

location_facility: Hôpital Felix Marechal 1 rue Xavier Roussel

location_facility: Résidence Mozart- Apt 56, 2 rue Jean Artus

location_facility: Hôtel les Cordeliers place des Cordeliers

location_facility: Hopital de Cimiez Pavillon Mossa 4 avenue de la Reine Victoria

location_facility: Hopital Bellier Service de Geronotologie 41 rue Curie

location_facility: Residence Le Gaughin Bat 1 68 rue Borely

location_facility: Hopital Charles Foix Service de Gerontologie 37 avenue de la Republique

location_facility: Impasse Mérite, Résidence Lamiot rue L'ecalier

location_facility: Résidence Emeraude 71 av Adolphe Geeraert

location_facility: 34 avenue de l'Europe Immeuble le Trident A1er etage

location_facility: Centre Commercial Tertifume 9 rue de Montreuil

location_facility: 5 rue Daniel Casanova Le Parc des Amandiers

location_facility: Centre Hospitalier Jacques Coeur Hopital Taillegrain Centre de Gerontologie des Pres Fichaux 6 rue Taillegrain

location_facility: Maison de retraite publique Centre de Memoire Route de Nimes

location_facility: 7 rue Raymond Boulogne Batiment C- apt 23

location_facility: Hopital Gui de Chauliac 80 rue Augustin Fliche

location_facility: Centre Hospitalier des Pyrenees Department de Psychogeriatrie 29 av du Marechal Leclerc

location_facility: 9, Résidence Haut Rivage, Rue Jean Xxiii

location_facility: Centre de Prevention des Alpes 3 place de Metz

location_facility: Centre Hospitalier de Purpan Service de Neurologie place du Docteur Baylac

location_facility: Immeuble Athéna 62 bis rue Aristide Briand

location_facility: Hôpital Broca - Service de Gérontologie Clinique 54-56 rue Pascal

location_facility: Espace Vénitien 1 av Pres Salvador Allende

location_facility: Hopital Cote de Nacre Service de Neurologie avenue de la cote de Nacre

location_facility: Hotel les Cordeliers place des Cordeliers

location_facility: Hopital St Joseph Service de Neurologie 26 boulevard Louvain

location_facility: Groupe Medical de Mazargues 1 av de la Martheline

location_facility: Hôpital Charles Nicolle Department de Neurologie 1, rue de Germont

location_facility: Cabinet de Neurologie 4 av Charles Tillon

location_facility: Centre Hospitalier Pellegrin-Tripode Service de Neurologie Place Amelie Raba-Leon

location_facility: Hopital STe Marguerite Unite de Neurologie 270 boulevard de STe Marguerite


title: Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas

acronym: CHIRACIC

summary: The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an intensive medical regimen in patients with hypertension.

study_start_date_type: Actual

status: Active, not recruiting

study_completion_date_type: Anticipated

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

lead_sponsor: University Hospital, Bordeaux

location_country: Italy Germany France

location_facility: Service d'Hypertension et de Médecine Vasculaire - Assistance Publique - Hôpitaux de Paris - Hôpital européen Georges Pompidou

location_facility: Service d'Endocrinologie, Diabétologie, Nutrition - CHU d'Amiens

location_facility: Département Endocrinologie-Diabétologie -Nutrition - CHU d'ANGERS

location_facility: Service d'Endocrinologie et Maladies Métabolique - CHU de Toulouse

location_facility: Service Endocrinologie, Diabétologie, maladies métaboliques - CHU de Bordeaux

location_facility: Assistance Publique - Hôpitaux de Paris - Hôpital COCHIN

location_facility: Endokrinologie, Diabetes und Ernährungsmedizin, Campus Mitte, Medizinische Klinik - Charité - Universitätsmedizin Berlin

location_facility: Service d'Endocrinologie, Diabète et Maladies Métaboliques - Assistance publique - Hôpitaux de Marseille

location_facility: Department of Internal Medicine I, Endocrine and Diabetes Uni -University Hospital Würzburg

location_facility: Service d'Endocrinologie, Diabétologie et Métabolisme - CHRU de LILLE

location_facility: Service d'Endocrinologie - Niveau 18 - Caen CHU Côte de Nacre

location_facility: Endocrinologie, Diabète et Maladies Métaboliques - CHU de Rouen

location_facility: CIC Endocrinologie-Nutrition - CHU de Nantes

location_facility: Service d'Endocrinologie et des Maladies de la Reproduction- Assistance Publique - Hôpitaux de Paris - Hôpial Bicêtre

location_facility: Service de Médecine Interne, Endocrinologie et Nutrition - CHU de Strasbourg

intervention_type: Procedure

lead_sponsor_type: academique

status_simplified: Ongoing


title: A National, Multicenter, Randomized Open-Label Study of Proctological Surgery Efficacy on Anoperineal Fistulas Healing in Crohn's Disease Patients Treated With Adalimumab. (Official French Title: "Étude Nationale, Multicentrique, randomisée et en Ouvert de l'efficacité de la Chirurgie Proctologique Sur la Cicatrisation Des Fistules anopérinéales de la Maladie de Crohn Chez Des Patients traités Par Adalimumab")

acronym: FACC

summary: The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.

status: Unknown status

enrollment_type: Anticipated

lead_sponsor: French Society of Coloproctology

location_facility: CHU de Rouen - Departement of Hepato Gastroenterologie and Nutrition

location_facility: Clinique universitaire de chirurgie Digestive et de l'urgence, Hopital Universitaire Michallon - Colorectal Surgery Unit

location_facility: Polyclinique de Franche-Comté - Department of Proctological Surgery

location_facility: CHU Pontchaillou - Department of Digestive Diseases

location_facility: Hôpital Nord de Marseille - Gastroenterology Department

location_facility: Maison de Santé Protestante de Bordeaux Bagatelle - Department of Proctology

location_facility: Clinique des Cèdres - Hepato-Gastroenterology Department

location_facility: Institut de Proctologie Léopold Bellan - Groupe Hospitalier Paris Saint Joseph - Department of Colo-Proctology

location_facility: Hôpital Bichat-Claude Bernard - Gastro-enterology Department

location_facility: Clinique Saint Jean Languedoc - Department of Gastroenterology

location_facility: Institut Mutualiste Montsouris - Proctology Unit

location_facility: CHU Bordeaux - Hôpital Saint André - Department of Hepato Gastroenterology

location_facility: Hôpital Louis Mourier - Department of Hepato-Gastroentérologie

lead_sponsor_type: industriel

status_simplified: Unknown


title: A Phase III Randomised, Double Blind, Placebo Controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of Continuing IRESSA 250 mg in Addition to Chemotherapy Versus Chemotherapy Alone in Patients Who Have Epidermal Growth Factor Receptor (EGFR) Mutation Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and Have Progressed on First Line IRESSA

acronym: IMPRESS

summary: The purpose of this study is to assess the efficacy and safety of gefitinib in patients who have progressed on first line gefitinib, comparing continuing gefitinib in addition to cisplatin plus pemetrexed combination chemotherapy versus cisplatin plus pemetrexed combination chemotherapy alone.

status: Completed

study_completion_date_type: Actual

ReferenceType: derived

ReferenceCitation: Soria JC, Wu YL, Nakagawa K, Kim SW, Yang JJ, Ahn MJ, Wang J, Yang JC, Lu Y, Atagi S, Ponce S, Lee DH, Liu Y, Yoh K, Zhou JY, Shi X, Webster A, Jiang H, Mok TS. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol. 2015 Aug;16(8):990-8. doi: 10.1016/S1470-2045(15)00121-7. Epub 2015 Jul 6.

family: Soria

full_name: Jean-Charles Soria

given: Jean-Charles

sequence: first

family: Wu

full_name: Yi-Long Wu

given: Yi-Long

sequence: additional

family: Nakagawa

full_name: Kazuhiko Nakagawa

given: Kazuhiko

family: Kim

full_name: Sang-We Kim

given: Sang-We

family: Yang

full_name: Jin-Ji Yang

given: Jin-Ji

family: Ahn

full_name: Myung-Ju Ahn

given: Myung-Ju

family: Wang

full_name: Jie Wang

given: Jie

full_name: James Chih-Hsin Yang

given: James Chih-Hsin

family: Lu

full_name: You Lu

given: You

family: Atagi

full_name: Shinji Atagi

given: Shinji

family: Ponce

full_name: Santiago Ponce

given: Santiago

family: Lee

full_name: Dae Ho Lee

given: Dae Ho

family: Liu

full_name: Yunpeng Liu

given: Yunpeng

family: Yoh

full_name: Kiyotaka Yoh

given: Kiyotaka

family: Zhou

full_name: Jian-Ying Zhou

given: Jian-Ying

family: Shi

full_name: Xiaojin Shi

given: Xiaojin

family: Webster

full_name: Alan Webster

given: Alan

family: Jiang

full_name: Haiyi Jiang

given: Haiyi

family: Mok

full_name: Tony S K Mok

given: Tony S K

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: The Lancet Oncology

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

lead_sponsor: AstraZeneca

location_country:
Italy
Hong Kong
Spain
France
Japan
Hungary
Russian Federation
China
Germany
Korea, Republic of
Taiwan

intervention_type: Drug

status_simplified: Completed


ReferenceCitation: Hopkins PN, Krempf M, Bruckert E, Donahue S, Yang F, Zhang Y, DiCioccio AT. Pharmacokinetic and pharmacodynamic assessment of alirocumab in patients with familial hypercholesterolemia associated with proprotein convertase subtilisin/kexin type 9 gain-of-function or apolipoprotein B loss-of-function mutations. J Clin Lipidol. 2019 Nov - Dec;13(6):970-978. doi: 10.1016/j.jacl.2019.10.007. Epub 2019 Oct 21.

family: Hopkins

full_name: Paul N. Hopkins

given: Paul N.

family: Krempf

full_name: Michel Krempf

given: Michel

family: Bruckert

full_name: Eric Bruckert

given: Eric

family: Donahue

full_name: Stephen Donahue

given: Stephen

full_name: Feng Yang

given: Feng

family: Zhang

full_name: Yi Zhang

given: Yi

family: DiCioccio

full_name: A. Thomas DiCioccio

given: A. Thomas

journal_name: Journal of Clinical Lipidology

oa_host_type: publisher

evidence: open (via crossref license)

host_type: publisher

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

version: publishedVersion

ReferenceCitation: Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri MA, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du Y, Hamon S, Krempf M, Swergold GD. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet. 2015 Dec;8(6):823-31. doi: 10.1161/CIRCGENETICS.115.001129. Epub 2015 Sep 15.

family: Defesche

full_name: Joep Defesche

given: Joep

family: Fouchier

full_name: Sigrid W. Fouchier

given: Sigrid W.

family: Luc

full_name: Gérald Luc

given: Gérald

family: Cariou

full_name: Bertrand Cariou

given: Bertrand

family: Sjouke

full_name: Barbara Sjouke

given: Barbara

family: Leren

full_name: Trond P. Leren

given: Trond P.

family: Harada-Shiba

full_name: Mariko Harada-Shiba

given: Mariko

family: Mabuchi

full_name: Hiroshi Mabuchi

given: Hiroshi

family: Rabès

full_name: Jean-Pierre Rabès

given: Jean-Pierre

family: Carrié

full_name: Alain Carrié

given: Alain

family: van Heyningen

full_name: Charles van Heyningen

given: Charles

family: Carreau

full_name: Valérie Carreau

given: Valérie

repository_institution: RCAAP Project by FCT - Portuguese National Funding Agency for Science, Research and Technology - RCAAP Search Portal

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Sorbonne Paris Nord

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

publisher: Ovid Technologies (Wolters Kluwer Health)

title: A Phase 2 Pilot Study With a Randomized Double-Blind Treatment Phase to Evaluate the Pharmacodynamics and Safety of Alirocumab in Patients With Autosomal Dominant Hypercholesterolemia and Gain-of-Function Mutations in 1 or Both Alleles of the PCSK9 Gene or Loss-of-Function Mutations in 1 or More Alleles of the Loss-of-Function Mutations B Gene

summary: The primary objective of the study is to assess the pharmacodynamic (PD) effect of alirocumab on serum low density lipoprotein cholesterol (LDL-C) during 14 weeks of subcutaneous (SC) administered alirocumab in patients with autosomal dominant hypercholesterolemia (ADH) and gain-of-function mutation (GOFm) in 1 or both alleles of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene or with loss-of-function mutation (LOFm) in 1 or more alleles of the apolipoprotein (ApoB) gene.


type: Other Identifier

title: An Open Label, Multicenter Phase 2 Study of Single-Agent Enzastaurin HCl in Previously Treated Waldenstrom's Macroglobulinemia or Multiple Myeloma

summary: To determine whether further study of single-agent enzastaurin is warranted in patients with previously treated Waldenstrom's Macroglobulinemia or Multiple Myeloma based on response.

lead_sponsor: Eli Lilly and Company

location_country:
United States
France

location_facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.


title: Open Label Multi-Centric Phase II Study of the Raf Kinase Inhibitor BAY 43-9006 in Chronic Myelogenous Leukemia (CML) Patients Resistant to Gleevec (Imatinib)

acronym: ORACLE

summary: The purpose of this study is to evaluate the anti-cancer activity and safety of Bay 43-006, in patients who have Chronic Myelogenous Leukemia that resisted to Gleevec treatment, one of the standard medication administered for these patients.

design_allocation: Non-Randomized

lead_sponsor: Bayer


title: Unruptured Cerebral Aneurysm: Prediction of Evolution

acronym: U-CAN

summary: The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.

status: Recruiting

study_type: Observational

time_perspective: Prospective

ipd_sharing: Undecided

lead_sponsor: Nantes University Hospital

location_country: France Switzerland Netherlands

location_facility:
Reims University Hospital
Brest University Hospital
Clairval's Hospital
Rennes University Hospital
Creteil University Hospital
AP-HP La Pitié-Salpêtrière Hospital
Nancy University Hospital
Rouen University Hospital
UMC Utrecht
Limoges University Hospital
Tours University Hospital
Amiens University Hospital
AP-HP Le Kremlin Bicêtre Hospital
Rostchild Foundation Hospital
InselHospital Bern
Angers University Hospital
Nantes University Hospital
Bordeaux University Hospital
Toulouse University Hospital
Ste Anne's Hospital

intervention_type: Other


title: ZEPHYR: Multicenter, Prospective, Randomized, Open-label Study in Consecutive Patients Hospitalized for Acute Respiratory Failure Requiring Mechanical Ventilation With Endotracheal Tube. This Study Compared Two Ventilation Modes: NAVA Mode and Spontaneous Breathing With Inspiratory Pressure Support (the Latter is Considered as the Reference Ventilation Mode).

summary: This is a multicenter, prospective, randomized, open-label study which compared two ventilation modes: spontaneous NAVA mode and spontaneous breathing with IPS mode (the latter is considered as the reference ventilatory mode) in patients admitted to the ICU for acute respiratory failure and ventilated with an endotracheal tube. NAVA mode allows to minimize patient-ventilator disharmony with acceptable tolerance and to preserve spontaneous ventilation.

primary_purpose: Supportive Care

ReferenceCitation: Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guerin C, Dellamonica J, Jaber S, Brochard L, Similowski T. Neurally adjusted ventilatory assist as an alternative to pressure support ventilation in adults: a French multicentre randomized trial. Intensive Care Med. 2016 Nov;42(11):1723-1732. Epub 2016 Sep 30.

lead_sponsor: Clinact

location_facility: Hopital de la Cote de Nacre - CHU de CAEN

location_facility: Groupe Hospitalier Sud - Hôpital Haut-Leveque - Maison du Haut-Leveque

intervention_type: Device


ReferenceCitation: Younossi ZM, Stepanova M, Racila A, Afendy A, Lawitz EJ, Schwabe C, Ruane PJ, Lalezari J, Reddy KR, Jacobson IM, Muir AJ, Gaggar A, Myers RP, Younossi I, Nader F. Long-term Benefits of Sustained Virologic Response for Patient-Reported Outcomes in Patients With Chronic Hepatitis C Virus Infection. Clin Gastroenterol Hepatol. 2020 Feb;18(2):468-476.e11. doi: 10.1016/j.cgh.2019.07.047. Epub 2019 Jul 31.

family: Younossi

full_name: Zobair M. Younossi

given: Zobair M.

family: Stepanova

full_name: Maria Stepanova

given: Maria

family: Racila

full_name: Andrei Racila

given: Andrei

family: Afendy

full_name: Arian Afendy

given: Arian

family: Lawitz

full_name: Eric J. Lawitz

given: Eric J.

family: Schwabe

full_name: Christian Schwabe

given: Christian

family: Ruane

full_name: Peter J. Ruane

given: Peter J.

family: Lalezari

full_name: Jay Lalezari

given: Jay

family: Reddy

full_name: K. Rajender Reddy

given: K. Rajender

family: Jacobson

full_name: Ira M. Jacobson

given: Ira M.

family: Muir

full_name: Andrew J. Muir

given: Andrew J.

family: Gaggar

full_name: Anuj Gaggar

given: Anuj

family: Myers

full_name: Robert P. Myers

given: Robert P.

full_name: Issah Younossi

given: Issah

family: Nader

full_name: Fatema Nader

given: Fatema

journal_name: Clinical Gastroenterology and Hepatology

lead_sponsor: Gilead Sciences

location_country:
Italy
Austria
United States
Sweden
Netherlands
Spain
Germany
France
Czechia
Poland
Australia
Belgium
New Zealand
Puerto Rico
Estonia
Canada
United Kingdom

location_facility: Azienda Ospedaliera - Polo Universitario Luigi Saco

location_facility: Regional Gastroenterology Associates of Lancaster, Ltd.

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: Hospital Universitario Marques de Valdecilla

location_facility: South Florida Center of Gastroenterology, P.A.

location_facility: Hôpital-Saint Joseph, Service D'Hépato-Gastroentérologie

location_facility: Chelsea and Westminster Hospital NHS Foundation Trust

location_facility: Weill Cornell Medical College of Cornell Univeristy

location_facility: Virginia Commonwealth University Medical Center

location_facility: Veterans Administration Wadsworth Medical Center

location_facility: Hospital Clinic I Provincial de Barcelona

location_facility: University of Wisconsin Hospital and Clinics

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: St. Luke's Health Baylor College of Medicine Medical Center

location_facility: Ente Ospedaliero Ospedali Galliera di Genova

location_facility: Columbia Presbyterian Hospital, Columbia University

location_facility: Schleinitz Research and Gastroenterology LLC

location_facility: The North Texas Clinical Research Institute

location_facility: Centre Hospitalier Universitaire de Grenoble

location_facility: The Gastroenterology Group of South Jersey

location_facility: Gastroenterologische Gemeinschaftspraxis Kiel Preetzer

location_facility: Spzoz Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego W Lodzi

location_facility: University of Birmingham and Queen Elizabeth Hospital Birmingham

location_facility: Azienda Ospedaliera S. Orsola - Malpighi

location_facility: Azienda Ospedaliera Padova, U.O.C. Cardiologia

location_facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino

location_facility: Centre Hospitalier Universitaire de Clermont-Ferrand

location_facility: Azienda Ospedaliera di Bologna - Policlinico S. Orsola Malpighi

location_facility: Sahlgrenska Universitetssjukhuset, Östra Sjukhus

location_facility: Guy's and Saint Thomas NHS Foundation Trust

location_facility: Lehigh Valley Health Network, Network Office of Research and Innovation

location_facility: UT Southwestern Medical Center at Dallas

location_facility: Gordon and Leslie Diamond Health Care Centre

location_facility: Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center

location_facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

location_facility: PraxisZentrum für Gastroenterologie und Endokrinologie

location_facility: Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren

location_facility: Université Libre de Bruxelles Hôpital Erasme

location_facility: University of California Davis Medical Center

location_facility: Hospital General Universitario de Valencia

location_facility: Vancouver Infectious Disease Research and Care Centre

location_facility: Centre Hospitalier de L'Universite de Montreal (CHUM)

location_facility: University of North Carolina at Chapel Hill

location_facility: Washington University School of Medicine

location_facility: Centre Hospitalier Universitaire Bordeaux Hôpital Haut-Lévêque

location_facility: Zentrum für Infektiologie Berlin Prenzlauer Berg GmbH

location_facility: Infectious Disease Specialists of Atlanta, PC

location_facility: Gastrointestinal Specialists of Georgia, PC

location_facility: Hospital Clínico Universitario Virgen de la Victoria

location_facility: Azienda Ospedaliera-universitaria Policlinico P. Giaccone

location_facility: Veterans Affairs Pittsburgh Healthcare System

location_facility: Community Research Initiative of New England

location_facility: Indianapolis Gastroenterology Research Foundation

location_facility: Hôpital Claude Huriez- Service d'Hépato-Gastroentérologie

location_facility: University of Florida Hepatology Research at CTRB

location_facility: Inova Fairfax Hospital Center for Liver Diseases

location_facility: Azienda Ospedaliera Ospedale Niguarda Ca' Granda

location_facility: University of Pennsylvania School of Medicine

location_facility: Advanced Clinical Research Institute, LLC

location_facility: Wojewódzki Szpital Specjalistyczny im. Kazimierza Dluskiego w Bialymstoku

location_facility: University of Texas Health Science Center at Houston

location_facility: Digestive Health Specialists of the Southeast, PA

location_facility: Ziekenhuis Netwerk Antwerpen Campus Stuivenberg

location_facility: Southampton University Hospitals NHS Trust, Southampton General Hospital

location_facility: Ospedale San Raffaele-IRCCS, Centro San Luigi - San Raffaele Turro, Unità Operativa di Malattie Infettive

location_facility: Binghamton Gastroenterology Associates, PC

location_facility: Instituto Nationale Per Le Malattie Infettive "Lazzaro Spallanzani"

location_facility: Asheville Gastroenterology Associates, P.A.

location_facility: Medizinische Universitätsklinik IV (Krehl Klinik) Abt. Gastroenterologie und Infektionskrankhen

location_facility: Hospital Universitario Nuestra Señora de Valme

location_facility: Nottingham University Hospitals NHS Trust

location_facility: Slezska nemocnice v Opave, Infekcni oddeleni

location_facility: Universitair Medisch Centrum Sint Radboud

location_facility: Southwest Infectious Disease Clinical Research, Inc

type: EudraCT Number

source: euctr

title: A Long Term Follow-up Registry for Subjects Who Achieve a Sustained Virologic Response to Treatment in Gilead-Sponsored Trials in Subjects With Chronic Hepatitis C Infection

summary: This Registry is designed to provide long term clinical and virologic follow up in participants who have achieved sustained virologic response (SVR) while participating in a previous Gilead sponsored hepatitis C virus (HCV) study. This long term follow up study is observational and no treatment is provided for HCV.


title: A Non-interventional Study to Assess the Hemoglobin Level Depending on the Comorbidity Index in Chronic Kidney Disease (CKD) Patients Not in Dialysis Treated With Mircera®

summary: This prospective, multicenter, observational study will evaluate the impact of comorbidity factors on the hemoglobin level in participants with chronic kidney disease who are not on dialysis and initiated on treatment with methoxy polyethylene glycol-epoetin beta (Mircera). Data will be collected for 9 months after initiation of methoxy polyethylene glycol-epoetin beta treatment.

lead_sponsor: Hoffmann-La Roche

location_facility: HOPITAL NORD; NEPH Transplantation Reanimation

location_facility: Centre Hospitalier De Sens; Nephrologie-Dialyse

location_facility: Hopital Hotel Dieu Et Hme; Hemodialyse Chronique

location_facility: Hopital de La Source; Service de Nephrologie & Hemodialyse

location_facility: Ctre Hosp St Joseph Et St Luc; Nephrologie Hemodialyse

location_facility: Association Aurad Aquitaine; Aurad Gradignan

location_facility: Hopital Bretonneau; Nephrologie Transplantations

location_facility: Chi Du Val D Ariege; Gastro Enterologie Nephrologie

location_facility: Hopital Albert Michallon; Clinique De Nephrologie

location_facility: Hopital Civil; Nephrologie Clinique Medicale B

location_facility: Ch Bretagne Atlantique De Vannes; Nephrologie

location_facility: Centre Hospitalier General; Service de Nephrologie-Hemodialyse

location_facility: Centre Hemodialyse St Augustin; Nephrologie

location_facility: Hopital Hotel Dieu Et HME; Nephrologie Immunologie Clinique

location_facility: Hopital Saint Louis; Service de Nephrologie - Transplantation

location_facility: Hopital Edouard-Herriot; Nephrologie - Hemodialyse

location_facility: Centre D'Hemodialyse Arnaud Tzanck; Service Nephrologie - Hemodialyse

location_facility: Ch De Beauvais; Neph Endocrino Dialyse Diabeto

location_facility: Ch de Brive la Gaillarde; Nephrologie Hemodialyse

location_facility: Hopital Clemenceau; Nephrologie Hemodialyse

location_facility: Hopital Pellegrin; Departement Nephrologie

location_facility: Ch Pitie Salpetriere; Nephrologie Hemodialyse

location_facility: Chic Cote Basque Bayonne; Nephrologie Hemodialyse

location_facility: Hopitaux Du Leman Site Thonon;Nephrologie

location_facility: Ch Lyon Sud; Nephrologie Sect Jules Courmont

location_facility: Hopital Hotel Dieu; Medecine Geriatrique Nephrologie

location_facility: Chu La Miletrie;Nephrologie Transplantation

location_facility: Ch Henri Duffaut; Nephrologie Hemodialyse

location_facility: Polyclinique De La Louviere; Nephrologie

location_facility: Centre De Sante Medical; Centre De Sante Republique

location_facility: Clinique de Tournan; Service de Nephrologie

location_facility: Association Pour L'Aide Des Uremiques de Bretagne

location_facility: Fondation Transplantation; Ctirc De Drevon

location_facility: Hopital Prive De L Estuaire; Nephrologie Hemodialyse

location_facility: Hopital Europeen Georges Pompidou; Service de Nephrologie

location_facility: Chi Poissy Saint Germain En Laye; Hemodialyse

location_facility: Centre de Dialyse Atirra; Service Nephrologie - Hemodialyse

location_facility: Ch Germon Et Gauthier; Medecine Interne Nephrologie

location_facility: Ch Antoine Gayraud; Nephrologie Hemodialyse

location_facility: Hopital Rangueil; Nephrologie Hemodialyse


title: Hypofractionated Stereotactic Radiation Treatments (SBRT) on Children, Teenagers and Young Adults Malignant Tumors

acronym: SBRT

summary: The purpose of this study is to evaluate the efficacy of hypofractionated stereotactic radiation treatments (SBRT) on children, teenagers and young adults malignant tumors.

ReferenceType: background

ReferenceCitation: Timmerman RD. An overview of hypofractionation and introduction to this issue of seminars in radiation oncology. Semin Radiat Oncol. 2008 Oct;18(4):215-22. doi: 10.1016/j.semradonc.2008.04.001.

ReferenceCitation: Rapport ANAES : Evaluation clinique et économique de la radiochirurgie intra cranienne en conditions stéréotaxique - Rapport ANAES/Service évaluation des technologies-évaluation économique: 2000.

ReferenceCitation: Rapport HAS : Radiothérapie extra crânienne en conditions stéréotaxiques - Décembre 2006: 2006.

ReferenceCitation: Maranzano E, Anselmo P, Casale M, Trippa F, Carletti S, Principi M, Loreti F, Italiani M, Caserta C, Giorgi C. Treatment of recurrent glioblastoma with stereotactic radiotherapy: long-term results of a mono-institutional trial. Tumori. 2011 Jan-Feb;97(1):56-61.

ReferenceCitation: Minniti G, Armosini V, Salvati M, Lanzetta G, Caporello P, Mei M, Osti MF, Maurizi RE. Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma. J Neurooncol. 2011 Jul;103(3):683-91. doi: 10.1007/s11060-010-0446-8. Epub 2010 Nov 5.

ReferenceCitation: Torok JA, Wegner RE, Mintz AH, Heron DE, Burton SA. Re-irradiation with radiosurgery for recurrent glioblastoma multiforme. Technol Cancer Res Treat. 2011 Jun;10(3):253-8.

ReferenceCitation: Zacharoulis S, Ashley S, Moreno L, Gentet JC, Massimino M, Frappaz D. Treatment and outcome of children with relapsed ependymoma: a multi-institutional retrospective analysis. Childs Nerv Syst. 2010 Jul;26(7):905-11. doi: 10.1007/s00381-009-1067-4. Epub 2009 Dec 29.

ReferenceCitation: Kano H, Yang HC, Kondziolka D, Niranjan A, Arai Y, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for pediatric recurrent intracranial ependymomas. J Neurosurg Pediatr. 2010 Nov;6(5):417-23. doi: 10.3171/2010.8.PEDS10252.

ReferenceCitation: Liu AK, Foreman NK, Gaspar LE, Trinidad E, Handler MH. Maximally safe resection followed by hypofractionated re-irradiation for locally recurrent ependymoma in children. Pediatr Blood Cancer. 2009 Jul;52(7):804-7. doi: 10.1002/pbc.21982.

ReferenceCitation: Combs SE, Behnisch W, Kulozik AE, Huber PE, Debus J, Schulz-Ertner D. Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma. BMC Cancer. 2007 Sep 13;7:177.

ReferenceCitation: Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K, Winick N, Mulne AF, Delp JL, Gilio JP, Gall KP, Dicke KA, Swift D, Sacco D, Harris-Henderson K, Bowers D. Robotically guided radiosurgery for children. Pediatr Blood Cancer. 2005 Sep;45(3):304-10.

ReferenceCitation: Grabb PA, Lunsford LD, Albright AL, Kondziolka D, Flickinger JC. Stereotactic radiosurgery for glial neoplasms of childhood. Neurosurgery. 1996 Apr;38(4):696-701; discussion 701-2.

ReferenceCitation: Hodgson DC, Goumnerova LC, Loeffler JS, Dutton S, Black PM, Alexander E 3rd, Xu R, Kooy H, Silver B, Tarbell NJ. Radiosurgery in the management of pediatric brain tumors. Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):929-35.

ReferenceCitation: Chawla S, Schell MC, Milano MT. Stereotactic body radiation for the spine: a review. Am J Clin Oncol. 2013 Dec;36(6):630-6. doi: 10.1097/COC.0b013e31822dfd71. Review.

ReferenceCitation: Lo SS, Sahgal A, Wang JZ, Mayr NA, Sloan A, Mendel E, Chang EL. Stereotactic body radiation therapy for spinal metastases. Discov Med. 2010 Apr;9(47):289-96. Review.

ReferenceCitation: Siva S, MacManus M, Ball D. Stereotactic radiotherapy for pulmonary oligometastases: a systematic review. J Thorac Oncol. 2010 Jul;5(7):1091-9. doi: 10.1097/JTO.0b013e3181de7143. Review.

ReferenceCitation: Fogh SE, Andrews DW, Glass J, Curran W, Glass C, Champ C, Evans JJ, Hyslop T, Pequignot E, Downes B, Comber E, Maltenfort M, Dicker AP, Werner-Wasik M. Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. J Clin Oncol. 2010 Jun 20;28(18):3048-53. doi: 10.1200/JCO.2009.25.6941. Epub 2010 May 17. Erratum in: J Clin Oncol. 2010 Sep 20;28(27):4280.

ReferenceCitation: Flannery T, Kano H, Martin JJ, Niranjan A, Flickinger JC, Lunsford LD, Kondziolka D. Boost radiosurgery as a strategy after failure of initial management of pediatric primitive neuroectodermal tumors. J Neurosurg Pediatr. 2009 Mar;3(3):205-10. doi: 10.3171/2008.11.PEDS08268.

ReferenceCitation: Conter C, Carrie C, Bernier V, Geoffray A, Pagnier A, Gentet JC, Lellouch-Tubiana A, Chabaud S, Frappaz D. Intracranial ependymomas in children: society of pediatric oncology experience with postoperative hyperfractionated local radiotherapy. Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1536-42. doi: 10.1016/j.ijrobp.2008.09.051. Epub 2009 Apr 11.

ReferenceCitation: Massimino M, Gandola L, Giangaspero F, Sandri A, Valagussa P, Perilongo G, Garrè ML, Ricardi U, Forni M, Genitori L, Scarzello G, Spreafico F, Barra S, Mascarin M, Pollo B, Gardiman M, Cama A, Navarria P, Brisigotti M, Collini P, Balter R, Fidani P, Stefanelli M, Burnelli R, Potepan P, Podda M, Sotti G, Madon E; AIEOP Pediatric Neuro-Oncology Group. Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study. Int J Radiat Oncol Biol Phys. 2004 Apr 1;58(5):1336-45.

ReferenceCitation: Sharma MS, Kondziolka D, Khan A, Kano H, Niranjan A, Flickinger JC, Lunsford LD. Radiation tolerance limits of the brainstem. Neurosurgery. 2008 Oct;63(4):728-32; discussion 732-3. doi: 10.1227/01.NEU.0000325726.72815.22.

ReferenceCitation: Merchant TE, Boop FA, Kun LE, Sanford RA. A retrospective study of surgery and reirradiation for recurrent ependymoma. Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):87-97. doi: 10.1016/j.ijrobp.2007.09.037.

lead_sponsor: Centre Leon Berard

location_facility: Institut de Cancérologie de l'Ouest René Gauducheau

intervention_type: Radiation


title: Phase III Study to Evaluate the Quality of Life in Elderly Patients With Metastatic Colorectal Cancer Receiving First-line Therapy Based on Simplified Geriatric Parameters

acronym: COLAGE

summary: A national, multicenter, open-label, randomized phase III study. The trial aim is to determine the best therapeutic strategies according with the HRQoL.

primary_purpose: Other

ipd_sharing: No

lead_sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group

location_facility: Hôpital des Diaconnesses Croix Saint Simon


title: Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment: a Two-part Clinical Study. PartA: Multisite MRI Acquisition, Protocol Harmonization. PartB: Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment: a Clinical Study

summary:
THE STUDY WILL BE A TWO-PART RESEARCH

PART A and PART A extended:

To implement a "common" MRI acquisition protocol in multiple centers across Europe (Pharma-COG partners).
Apply the common MRI protocol on phantoms and human subjects to characterize, compare and minimize test-retest variability across the MR sites of WP5 for all the quantitative metrics that will be later assessed on patients.

PART B: By collecting clinical, biochemical, neuroimaging, neuropsychological and neurophysiological data in Mild Cognitive Impairment patient, we aim to:

To develop a biomarker MATRIX (made of a combination of biological secondary endpoints) which is more sensitive than the changes observed in the loss of hippocampal volume (primary endpoint) and correlate with the neuropsychological progression and conversion (clinical secondary endpoints).
To develop a biomarker MATRIX (made of a combination of biological secondary endpoints) at baseline which is more predictive of the loss of hippocampal volume (primary endpoint) and neuropsychological progression (clinical secondary endpoint) in MCI patients.
To harmonize the biomarker MATRIX collection and qualify multiple centres across Europe

primary_purpose: Prevention

ReferenceCitation: Grady CL, Haxby JV, Horwitz B, Sundaram M, Berg G, Schapiro M, Friedland RP, Rapoport SI. Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J Clin Exp Neuropsychol. 1988 Oct;10(5):576-96.

lead_sponsor: Qualissima

location_country: Italy Netherlands France Greece Spain Germany

location_facility: Hospital and Institute of the University of Duisburg and Essen - Department for Psychiatry and Psychotherapy, LVR Hospital Essen

location_facility: Neurofisiologia Clinica IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Padiglione Specialita' piano Fondi

location_facility: IRCCS Fondazione SDN per la Ricerca e l'Alta Formazione in Diagnostica Nucleare di Napoli

location_facility: University Hospital of Leipzig - Department of Psychiatry

location_facility: IRCCS-FBF - Ordine Ospedaliero San Giovanni di Dio, Fatebenefratelli, Istituto di Ricovero e Cura a Carattere Scientifico

location_facility: Aristotle University of Thessaloniki, Greek Association of Alzheimer's disease and related disorders, Thessaloniki, Greece

location_facility: Université Lille 2, UL2 - Centre d'investigation clinique / Centre de Ressources biologiques 9301 - INSERM - Centre Hospitalier Régional et Universitaire de LILLE

location_facility: Institut d'Investigacions Biomèdiques August Pi I Sunyer, IDIBAPS

location_facility: Dipartimento di Specialità medico-chirurgiche e Sanità Pubblica, Sezione di Clinica Neurologica, Centro Disturbi della Memoria, Perugia, Italy

location_facility: Università Cattolica del Sacro Cuore - Policlinico Agostino Gemelli Istituto di Neurologia - Neuropsychological and Neurorehabilitation Unit

location_facility: APHM, Hopital de la Timone, Service de Neurologie et Neuropsychologie


title: Aquagenic Pruritus in Myeloproliferative Neoplasms

acronym: PANAM

summary:
Description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms.

Prospective work based on the distribution of a dedicated questionnaire.

ipd_sharing: Yes

ipd_sharing_description: All collected data that underlie results in a publication

lead_sponsor: University Hospital, Brest


acronym: MISTRAL

location_facility: Unite Autodialyse Paris 14; Dialyse A Domicile

location_facility: Hopital Manchester; Nephrologie Hemodialyse

location_facility: Ch Pitie Salpetriere; Nephrologie Hemodialyse

location_facility: Polyclin Bordeaux Nord Aquitaine; Nephrologie - Hemodialyse

location_facility: HOPITAL NORD; NEPH Transplantation Reanimation

location_facility: Hôpital Des Brousailles; Service de Néphrologie

location_facility: Ch Georges Renon; Nephrologie Hemodialyse

location_facility: Hopital Civil; Nephrologie Clinique Medicale B

location_facility: Hopital National; Nephrologie Hemodialyse

location_facility: Hopital de La Source; Service de Nephrologie & Hemodialyse

location_facility: Chu La Miletrie;Nephrologie Transplantation

location_facility: Hopital Louis Pasteur; Nephrologie - Hemodialyse

location_facility: Hopital Marc Jacquet; Nephrologie Hemodialyse

location_facility: Hopital Calmette; Medecine General & Nephrologie Serv.

location_facility: Hopital Clemenceau; Nephrologie Hemodialyse

location_facility: Hopital De La Maison Blanche; Nephrologie Hemodialyse

location_facility: CH Bretagne Atlantique de Vannes; Hemodialyse

location_facility: CH de Saintonge; Unite 1 Med Interne Nephrologie

location_facility: Ch Du Cotentin Site De Cherbourg; Nephrologie

location_facility: Hopital Bichat Claude Bernard; Nephrologie

title: A Single Arm, Open-Label, Multicentre Study to Assess the Maintenance of Haemoglobin Levels With Once Monthly Subcutaneous Administration of C.E.R.A (Continuous Erythropoietin Receptor Activator) in Patients With Chronic Kidney Disease on Peritoneal Dialysis

summary: This single-arm study will assess the efficacy and safety of monthly administration of SC Mircera for the maintenance of hemoglobin levels in participants with chronic kidney disease on peritoneal dialysis. Participants currently receiving maintenance treatment with SC erythropoietin stimulating agents (ESAs) will receive monthly SC injections of Mircera, with the starting dose derived from the last weekly ESA they had been receiving.


title: IN.PACT™ Quality of Life Post-Reimbursement Study

summary: To prospectively collect and assess the perception of health-related Quality of Life, Pain and Walking Ability.

lead_sponsor: Medtronic

location_facility: Centre Hospitalier Clermont-Ferrand- Gabriel-Montpied

location_facility: Hopitaux Universitaires de Strasbourg - Nouvel Hopital Civil

location_facility: Hopitaux Universitaires Paris lle-France Ouest- Hopital Ambroise- Pare

intervention_type: Combination Product


title: A Multicenter Open Label Study on the Safety and Efficacy of Deflazacort (Emflaza®) in Subjects With Limb-Girdle Muscular Dystrophy 2I (LGMD2I)

summary: This study is designed to evaluate the safety and efficacy of deflazacort in participants with LGMD2I. Most participants enrolled will have a screening visit and 3 additional visits (after 1, 13, and 26 weeks of treatment).

lead_sponsor: PTC Therapeutics

location_country:
Sweden
Germany
France
Norway
Russian Federation
Denmark
United States
Canada

location_facility: Hugo W Moser Research Institute at Kennedy Krieger Institute

location_facility: Washington University School of Medicine

location_facility: University of Iowa Hospitals and Clinics

location_facility: Rigshospitalet, University of Copenhagen

location_facility: Ludwig-Maximilians University Munich, Friedrich-Baur-Institute

location_facility: Saint-Petersburg State Pediatric Medical University

location_facility: Pirogov Russian National Research Medical University


ReferenceCitation: Younossi ZM, Stepanova M, Racila A, Afendy A, Lawitz EJ, Schwabe C, Ruane PJ, Lalezari J, Reddy KR, Jacobson IM, Muir AJ, Gaggar A, Myers RP, Younossi I, Nader F. Long-term Benefits of Sustained Virologic Response for Patient-Reported Outcomes in Patients With Chronic Hepatitis C Virus Infection. Clin Gastroenterol Hepatol. 2020 Feb;18(2):468-476.e11. doi: 10.1016/j.cgh.2019.07.047. Epub 2019 Jul 31.

ReferenceCitation: Younossi ZM, Stepanova M, Jacobson I, Muir AJ, Pol S, Zeuzem S, Younes Z, Herring R, Lawitz E, Younossi I, Racila A. Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes. Clin Infect Dis. 2020 Feb 3;70(4):628-632. doi: 10.1093/cid/ciz243.

name: Center for Liver Diseases, Department of Medicine

name: Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia

full_name: Zobair M Younossi

given: Zobair M

name: Center for Outcomes Research Liver Diseases, Washington, DC

full_name: Ira Jacobson

given: Ira

name: Duke Clinical Research Institute, Durham, North Carolina

full_name: Andrew J Muir

given: Andrew J

name: Hopital Cochin, Universite Paris Descartes, France

family: Pol

full_name: Stanislas Pol

given: Stanislas

family: Zeuzem

full_name: Stefan Zeuzem

given: Stefan

family: Younes

full_name: Ziad Younes

given: Ziad

name: Quality Medical Research, Nashville, Tennessee

family: Herring

full_name: Robert Herring

name: Texas Liver Institute, University of Texas Health, San Antonio

location_country:
Italy
Austria
United States
Sweden
Netherlands
Germany
France
Czechia
Poland
Australia
Puerto Rico
New Zealand
Spain
Estonia
Canada
United Kingdom

location_facility: Pointe West Infectious Diseases d/b/a Bach and Godofsky Infectious Diseases

location_facility: Medizinisches Zentrum - Klinik für Gastroenterologie und Hepatologie

location_facility: Regional Gastroenterology Associates of Lancaster, Ltd.

location_facility: Los Angeles BioMedical Institute at Harbor-UCLA Medical Center

location_facility: Nashville Gastrointestinal Specialists, Inc

location_facility: Waikato Hospital (District Health Board)

location_facility: Klinikum der Johann Wolfgang-Goethe-Universität

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: South Florida Center of Gastroenterology, P.A.

location_facility: SP ZOZ Wojewodzki Szpital Zakazny w Warszawie

location_facility: Hôpital-Saint Joseph, Service D'Hépato-Gastroentérologie

location_facility: Center for HIV and Hepatogastroenterology

location_facility: Chelsea and Westminster Hospital NHS Foundation Trust

location_facility: Liver Institute of Virginia, Bon Secours Health System

location_facility: Virginia Commonwealth University Medical Center

location_facility: University of California, San Francisco School of Medicine

location_facility: Veterans Administration Wadsworth Medical Center

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: Hospital Moncloa, Servicio de Enfermedades Infecciosas

location_facility: St. Luke's Health Baylor College of Medicine Medical Center

location_facility: Ente Ospedaliero Ospedali Galliera di Genova

location_facility: Hôpital La Pitié Salpétrière, Service des Maladies Infectieuses

location_facility: Schleinitz Research and Gastroenterology LLC

location_facility: Ospedale San Raffaele-IRCCS, Centro San Luigi - San Raffaele Turro, Unità Operativa di Malattie Infettive

location_facility: Centre Hospitalier Universitaire de Grenoble

location_facility: University of Kansas Medical Center Research Institute, Inc.

location_facility: The Gastroenterology Group of South Jersey

location_facility: University of Birmingham and Queen Elizabeth Hospital Birmingham

location_facility: Centrum Badan Klinicznych Osrodek Badan Wczesnej Fazy

location_facility: Azienda Ospedaliera S. Orsola - Malpighi

location_facility: Azienda Ospedaliera Padova, U.O.C. Cardiologia

location_facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino

location_facility: Service des Maladies de l'Appareil Digestif et de la nutrition

location_facility: Kansas City Gastroenterology and Hepatology

location_facility: Centre Hospitalier Universitaire de Clermont-Ferrand

location_facility: Azienda Ospedaliera di Bologna - Policlinico S. Orsola Malpighi

location_facility: Sahlgrenska Universitetssjukhuset, Östra Sjukhus

location_facility: Guy's and Saint Thomas NHS Foundation Trust

location_facility: Lehigh Valley Health Network, Network Office of Research and Innovation

location_facility: Kaiser Permanente Institute for Health Research

location_facility: Klinik für Gastroenterologie und Hepatologie am Abdominalzentrum

location_facility: UT Southwestern Medical Center at Dallas

location_facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

location_facility: Universitätsklinikum Würzburg - Med Klinik und Poliklinik

location_facility: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

location_facility: C.H.U. Strasbourg - Hôpital Hautpierre - Hématologie

location_facility: Hospital General Universitario de Valencia

location_facility: Remedis, s.r.o., Nestátní zdravotnické zarízení, Vladimírova 10

location_facility: Institut für interdisziplinäre Medizin Studien GmbH an der Asklepiosklinik Saint Georg

location_facility: Dipartimento Polispecialistico - Malattie Infetive

location_facility: Vancouver Infectious Disease Research and Care Centre

location_facility: Hospital Clinic I Provincial de Barcelona

location_facility: University of North Carolina at Chapel Hill

location_facility: Sahlgrenska Universitetssjukhuset, Östra sjukhuset

location_facility: Wojewódzki Szpital Specjalistyczny im. Kazimierza Dluskiego w Bialymstoku

location_facility: Gastrointestinal Specialists of Georgia, PC

location_facility: University of Utah Pediatric Pulmonology

location_facility: Gordon & Leslie Diamond Health Care Centre

location_facility: Azienda Ospedaliera-universitaria Policlinico P. Giaccone

location_facility: Veterans Affairs Pittsburgh Healthcare System

location_facility: Community Research Initiative of New England

location_facility: Indianapolis Gastroenterology Research Foundation

location_facility: Hôpital Claude Huriez- Service d'Hépato-Gastroentérologie

location_facility: Inova Fairfax Hospital Center for Liver Diseases

location_facility: Azienda Ospedaliera Ospedale Niguarda Ca' Granda

location_facility: University of Pennsylvania School of Medicine

location_facility: Klinikum der Johann Wolfgang Goethe Universitaet

location_facility: Advanced Clinical Research Institute, LLC

location_facility: University of Manitoba, Health Sciences Center

location_facility: Hôpital Saint Louis, Services des Maladies Infectieuses

location_facility: University of Miami Miller School of Medicine

location_facility: Southampton University Hospitals NHS Trust, Southampton General Hospital

location_facility: Alfred Hospital - Infectious Disease Unit

location_facility: Weill Medical College of Cornell Univeristy

location_facility: Asheville Gastroenterology Associates, P.A.

location_facility: Research Center at Affiliates in Gastroenterology

location_facility: Medizinische Universitätsklinik IV (Krehl Klinik) Abt. Gastroenterologie und Infektionskrankhen

location_facility: Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego

location_facility: Hospital Universitario Nuestra Señora de Valme

location_facility: Infectious Disease Specialists of Atlanta

location_facility: Universitair Medisch Centrum Sint Radboud

location_facility: St. Joseph's Comprehensive Research Institute

location_facility: Gastroenterology Center of the MidSouth, P.C.

title: A Long Term Follow-up Registry Study of Subjects Who Did Not Achieve Sustained Virologic Response in Gilead-Sponsored Trials in Subjects With Chronic Hepatitis C Infection

summary: This Registry is designed to obtain long term data on participants who have failed to achieve sustained virologic response (SVR) while receiving at least one Gilead oral antiviral agent (OAV) in a previous Gilead-sponsored hepatitis C virus (HCV) study.


title: Study Evaluating the Performance and Safety in the Medium Term of Implant-prosthetic Systems Including Ranges of Dental Implants and Prosthetic Components Global D: In-Kone® U,In-Kone® P,3.0,twinKon® U,EVL® S,EVL® K,EVL® C

summary: This study is set up within the framework of the European Union regulation 2017/745 on medical devices. Its objective is to confirm the performance and safety in the medium term of implant-prosthetic systems including Global D dental implants: In-Kone® UNIVERSAL, In-Kone® PRIMO, 3.0, twinKon® UNIVERSAL, EVL® S, EVL® K and EVL® C.

time_perspective: Other

lead_sponsor: Global D

location_country: France Greece


type: Other Grant/Funding Number

title: Exploratory Multicenter Observational Study to Assess the Outcome of Infants With Perinatal SARS-COV-2 Infection and Its Link With the NO Pathway: the Minipuberty Hypothesis

acronym: miniNO-COVID

summary: Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal (HPG) axis, and specifically with its transient activation occurring during infancy, namely minipuberty, is a major concern. Among the various pathogenic features related to COVID-19, altered minipuberty could be a key factor underlying many multimorbidities later in life, suggesting that they could involve a common causative mechanism that occurs within this short and critical period of time following birth. Altered minipuberty together with NO deficiency seem to be key factors underlying many of these multimorbidities, suggesting that they involve a common causative mechanism that occurs within this short and critical period of time following birth

study_start_date_type: Anticipated

status: Not yet recruiting

lead_sponsor: University Hospital, Lille

location_facility: Uri-National and Kapodistrian University of Athens


title: Observational Multicenter Prospective Clinical Study on the Total Ankle Prosthesis, EasyMove®, Evaluating Safety and Performance up to 5 Years of Follow-up

summary: This study is a post-market clinical follow-up conducted in order to collect long-term data on safety and performance of the EasyMove prosthesis, which is intended to be implanted in case of total ankle replacement, when used in real life conditions according to the instructions for use.

lead_sponsor: FH ORTHO

location_country: France Switzerland

location_facility: Centre hospitalier universitaire vaudois


title: Prospective Registry of Transarterial Chemoembolization of Metastatic Colorectal Cancer to the Liver With HepaSphere™ Microspheres Loaded With Irinotecan

acronym: mCRC

summary: HepaSphere Microspheres loaded with irinotecan received CE mark for the indication of use in embolization of mCRC to the liver in 2015. The goal of this registry is to add to the understanding of the use and value of transarterial chemoembolization with HepaSphere in 'real life' usage conditions.

lead_sponsor: Merit Medical Systems, Inc.

location_facility:
European Hospital Georges Pompidou
Evgenidio Hospital/ATTIKO Hospital


title: Effectiveness and Safety of STYLAGE® L Lidocaïne in the Treatment of Nasolabial Folds

acronym: NICE

summary: STYLAGE® L Lidocaine is a CE-marked hyaluronic acid gel intended to fill skin depressions on the face by dermal injection. In this study, 50 healthy subjects between the age of 30 and 65, with moderate to severe nasolabial folds as assessed in live, who have given their informed consent and met all eligibility criteria, will be enrolled. Subjects will randomly receive injection of STYLAGE® L Lidocaine on one nasolabial fold and injection of an active comparator on the other nasolabial fold. A touch-up is possible if required one month after. Subjects will come to a total of 7 visits over a period of 12 months. Variation in severity score of nasolabial folds will be assessed in live and on photographs by independent evaluators. Variation in nasolabial fold depth, global aesthetic improvement, subject satisfaction, pain at injection site and safety will also be assessed.

lead_sponsor: Laboratoires Vivacy

location_country: France Poland

location_facility:
Eurofins Dermscan Poland
Eurofins Dermscan Pharmascan


type: Registry Identifier

title: A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alpha for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Due to Myelodysplastic Syndrome (MDS) ESA in Native Subjects Who Require Red Blood Cell Transfusions

acronym: COMMANDS

summary:
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.

This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) versus epoetin alfa for the treatment of anemia due to IPSS-R very low, low or intermediate risk MDS in ESA naïve subjects who require RBC transfusions.

The study is divided into the Screening Period, a Treatment Period and a Post-Treatment Follow-up Period.

lead_sponsor: Celgene

location_country:
Greece
Australia
Belgium
Russian Federation
Taiwan
Ukraine
France
Japan
Lithuania
Poland
Canada
Korea, Republic of
Sweden
Switzerland
Netherlands
Hungary
Portugal
United States
Germany
United Kingdom
Italy
Austria
Czechia
Israel
Spain
Turkey

location_facility: Akademicki Szpital Kliniczny Klinika Reumatologii i Chorob Wewnetrznych

location_facility: General Hospital of Athens - George Gennimatas

location_facility: Centre Hospitalier Universitaire de Grenoble Hopital Albert Michallon

location_facility: National Hospital Organization - Nagoya Medical Center

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

location_facility: Moscow State Healthcare Institution City clinical hospital n.a. S.P.Botkin

location_facility: National Hospital Organization Kyushu Medical Center

location_facility: Dnipropetrovsk City Multidisciplinary Clinical Hospital No 4, Hematological Center

location_facility: Florida Cancer Specialists North Region Sarah Cannon Research

location_facility: Hopital Maisonneuve Rosemont dba CIUSSS de lEst de lIle de Montreal

location_facility: Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (I.R.S.T.)

location_facility: Hospital of Lithuanian University Health and Sciences

location_facility: The Japanese Red Cross Nagasaki Genbaku Hospital

location_facility: Del-pesti Centrumkorhaz- Orszagos Hematologiai és Infektologiai Intezet

location_facility: Wojewodzki Szpital Specjalistyczny im Korczaka w Supsku

location_facility: The Catholic University of Korea Seoul - Saint Mary's Hospital

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Hospital Universitario Virgen De La Victoria

location_facility: Hyogo Prefectural Amagasaki General Medical Center

location_facility: Centre Hospitalier Universitaire de Sherbrooke CHUS

location_facility: Institute of Blood Pathology and Transfusion Medicine of the UAMS

location_facility: Azienda Ospedaliero - Universitaria San Luigi Gonzaga

location_facility: Szpital Kliniczny im. H.Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu

location_facility: Utah Cancer Specialists - South Salt Lake

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz , Josa Andras Oktatókórház

location_facility: Azienda Ospedaliera Universitaria Careggi

location_facility: Vilnius University Hospital Santariskiu Klinikos

location_facility: H. Hartziekenhuis Roeselare-Menen vzw campus Wilgenstraat

location_facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

location_facility: Azienda Ospedaliera Bianchi Melacrino Morelli

location_facility: Instituto Portugues de Oncologia de Lisboa, Francisco Gentil

location_facility: Tel Aviv Sourasky Medical Center Department of Hematology

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: Alabama Oncology - Grandview Cancer Center

location_facility: Debreceni Egyetem Orvos- es Egeszsegtudomanyi Centrum

location_facility: Chonnam National University Hwasun Hospital

location_facility: Hospital Universitario Central de Asturias

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroclawiu

location_facility: Ipo Instituto Portugues De Oncologia Porto

location_facility: State Institution National Research Centre for Radiation Medicine of NAMS of Ukraine

location_facility: Medizinisches Versorgungszentrum (MVZ) Onkologischer Schwerpunkt am Oskar-Helene-Heim

location_facility: Georgios Papanikolaou General Hospital of Thessaloniki

location_facility: Hospital General Universitario Morales Meseguer

location_facility: Kliniczny Szpital Wojewodzki nr 1 im. Fryderyka Chopina w Rzeszowie

location_facility: Istituto di Ematologia L. e A. Seragnoli-Azienda Ospedaliero Universitaria Policlinico S. Orsola M

location_facility: Assistance Publique - Hopitaux de Paris - Hopitaux Saint-Louis

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: Seoul National University Bundang Hospital

location_facility: Klinikum rechts der Isar der Technischen Universitaet Muenchen

location_facility: Klinkum der Stadt Villingen-Schwenningen GmbH

location_facility: Karadeniz Technical University Medical Faculty

location_facility: Praxis fuer Haematologie und Onkologie Koblenz

location_facility: Samodzielny Publiczny Szpital Kliniczny nr 1 Klinika Hematoonkologii i Transplantacji Szpiku

location_facility: Western Kentucky Hematology and Oncology Group

location_facility: First Pavlov State Medical University of St. Petersburg

location_facility: Federal State Institute Kirov Research Inst. of Hematology and Blood Transfusion of Rosmedtec

location_facility: Federal Centre of Heart, Blood and Endocrinology of Rosmed technlologies V.A. Almazov

location_facility: Instituto Catalan de Oncologia-Hospital Duran i Reynals

location_facility: Border Medical Oncology - Albury Wodonga Regional Cancer Centre

location_facility: Ärzte f. Innere Medizin Gemeinschaftspraxis f. Hamatologie u. Onkologie

location_facility: Specjalistyczny Szpital im. dra Alfreda Sokolowskiego

location_facility: Institut de Cancérologie Strasbourg Europe

location_facility: University General Hospital of Heraklion

location_facility: AHEPA University General Hospital of Thessaloniki

location_facility: Karolinska Universitetssjukhuset - Huddinge

location_facility: Azienda Ospedaliero-Universitaria Santa Maria della Misericordia die Udine

location_facility: National Association of Veterans Research and Education Foundations (NAVREF)


title: Evaluation of (Doravirine / Lamivudine / Tenofovir Disoproxil Fumarate) (Delstrigo®) as a New Strategy for Non-occupational Post Exposure Prophylaxis, a Prospective Open Label Study

acronym: DORAVIPEP

summary: Subjects who go to emergency room for possible contact to HIV transmission receive Delstrigo as post exposition prophylaxis.

lead_sponsor: David Garcia Cinca

location_country: France Spain

location_facility: Department and HIV & HCV Clinical Research Unit University Hospital Nantes


title: Clinical Application of the European Horizon 2020 Research Project "BRIDGES" - Study of the Psychological Impact of Breast Cancer Risk Communication in Cancer Genetics Based on the Personalized Estimation of the BOADICEA V5/PLUS Model

summary: Study of the psychological impact of breast cancer risk communication in Cancer Genetics based on the personalized estimation of the BOADICEA V5/PLUS model ("Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm-version 5 or PLUS").

lead_sponsor: Institut Curie

location_country: Germany France

location_facility:
University Hospital of Cologne
Institut Curie

intervention_type: Behavioral


title: MOdified DIagnostic strateGy to Safely ruLe-out Pulmonary Embolism In the Emergency depArtment: A Non-Inferiority Cluster Cross-over Randomized Trial

acronym: MODIGLIA-NI

summary:
Because a missed PE could be potentially lethal, several researches reported that PE is both overinvestigated and overdiagnosed. The diagnostic gold standard for PE is the computed tomographic pulmonary angiogram (CTPA) and has been shown to have clear risks and other downsides. To limit the use of CTPA, two rules were recently reported to be safe to exclude PE: the PERC rule and the YEARS rule. PERC is an 8 item block of clinical criteria that has recently been validated to safely exclude PE in low risk patients. YEARS is a clinical rule that allow to raise the threshold of D-dimer for the order of CTPA. However, whether a modified diagnostic algorithm that includes these two rules combined could safely reduce imaging study use in the ED is unknown.

This is a non-inferiority, cluster cross-over randomized, international trial.

Each center will be randomized on the sequence of period intervention: 4 months intervention (MOdified Diagnostic Strategy: MODS) followed by 4 months control (usual care), or 4 months control followed by 4 months intervention with 1 month of "wash-out" between the two periods.

All centers will recruit adult emergency patients with a suspicion of PE.

In the control group (usual strategy), patients will be tested for D-dimer, followed if positive by a CTPA.

In the intervention group (MODS) :

All included patients will be tested with quantitative D-dimer. The MODS work-up will be based on YEARS rule :

- If all YEARS criteria are absent, the threshold of D-Dimer for ordering a CTPA will be raised.

If at least one criterion of YEARS is present, then the D-dimer threshold for ordering a CTPA will be as usual.

primary_purpose: Diagnostic

ReferenceCitation: Philippon AL, Dumont M, Jimenez S, Salhi S, Cachanado M, Durand-Zaleski I, Simon T, Freund Y. MOdified DIagnostic strateGy to safely ruLe-out pulmonary embolism In the emergency depArtment: study protocol for the Non-Inferiority MODIGLIANI cluster cross-over randomized trial. Trials. 2020 Jun 3;21(1):458. doi: 10.1186/s13063-020-04379-y.

family: Philippon

full_name: Anne-Laure Philippon

given: Anne-Laure

family: Dumont

full_name: Margaux Dumont

given: Margaux

family: Jimenez

full_name: Sonia Jimenez

given: Sonia

family: Salhi

full_name: Sarah Salhi

given: Sarah

family: Cachanado

full_name: Marine Cachanado

given: Marine

family: Durand-Zaleski

full_name: Isabelle Durand-Zaleski

given: Isabelle

family: Simon

full_name: Tabassome Simon

given: Tabassome

family: Freund

full_name: Yonathan Freund

given: Yonathan

currency_apc_doaj: GBP

journal_name: Trials

oa_colors: green gold

oa_host_type: publisher;repository

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

license_normalized: no license

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer

ipd_sharing_description: Yes, upon request, after approval by the primary investigator and clinical research platform of East Paris. For the purpose of IPD meta-analysis, or secondary analysis. Unidentifying data will be shared.

lead_sponsor: Assistance Publique - Hôpitaux de Paris

location_facility: Emergency department Hospital Pitié-Salpêtrière


title: FENIX™ Continence Restoration System Registry

summary: The FENIX Registry is a multi-center, observational database designed to collect data regarding the FENIX™ Continence Restoration System in everyday clinical practice, evaluate the clinical course of patients from pre-operative assessment through five years post-surgery and Track and monitor effectiveness and safety through the use of a bowel diary, fecal incontinence quality-of-life measures and adverse event reporting. Up to 25 sites will participate in the Registry. Sites to enroll consecutive eligible patients into the Registry. Registry will enroll approximately 200 FENIX patients.

lead_sponsor: Torax Medical Incorporated

location_facility:
University Hospital of Nantes
Kliniken Essen-Mitte


title: Tailored Intervention on Nutrition and Exercise for Obstructive Sleep Apnea Patients Treated With CPAP

acronym: TINE

summary: This study evaluates the addition of a comprehensive lifestyle program including dietary management and exercise to continuous positive airway pressure (CPAP) therapy in overweighted adults with obstructive sleep apnea. Half of the participants will receive CPAP therapy while the other half will have diet consultations, nordic walking sessions and CPAP.

lead_sponsor: Raphael Heinzer

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: Centre Hospitalier Universitaire Saint-Etienne


title: Biomechanics and Motor Control of the First 6 Months of Independent Walking for Children With Unilateral Cerebral Palsy

acronym: BB-AQM

summary: This study will focus the gait analysis, using an optoelectronic system, of children with unilateral cerebral palsy compared to typically developed children in the first 6 months of independent walking.

time_perspective: Retrospective

location_country: Romania France

location_facility: Centrul National Clinic Recuperare Copii "Dr. N. Robanescu"

intervention_type: Diagnostic Test


title: Feasibility of Implementing a Cohort of People Living With Hepatitis C in the Viet Tiep Hospital in Hai Phong, Vietnam

acronym: CoViet-C

summary: The purpose of this study is to evaluate the feasibility of implementing a cohort of patients with Hepatitis C in order to generate a larger cohort for future studies

lead_sponsor: Centre Hospitalier Universitaire de Nīmes

location_country: France Vietnam

location_facility:
CHU Nimes
Hospital Viet Tiep


title: Evaluation of MDW for Early Detection of Sepsis In the Emergency Department

summary: The purpose of this study is to confirm the clinical validity and the performance of the Monocyte Width Distribution (MDW) parameter to detect the development of sepsis in a prospective study of Emergency Department (ED) adults who have blood draw including Complete Blood Count with differential (CBC-DIFF) ordered upon presentation in a Spanish & French hospital and to verify cut-off for Tri-potassium ethylenediaminetetraacetic acid (K3EDTA).

ReferenceCitation: Hausfater P, Robert Boter N, Morales Indiano C, Cancella de Abreu M, Marin AM, Pernet J, Quesada D, Castro I, Careaga D, Arock M, Tejidor L, Velly L. Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study. Crit Care. 2021 Jun 30;25(1):227. doi: 10.1186/s13054-021-03622-5.

family: Hausfater

full_name: Pierre Hausfater

given: Pierre

family: Robert Boter

full_name: Neus Robert Boter

given: Neus

family: Morales Indiano

full_name: Cristian Morales Indiano

given: Cristian

family: Cancella de Abreu

full_name: Marta Cancella de Abreu

given: Marta

family: Marin

full_name: Adria Mendoza Marin

given: Adria Mendoza

family: Pernet

full_name: Julie Pernet

given: Julie

family: Quesada

full_name: Dolores Quesada

given: Dolores

family: Castro

full_name: Iris Castro

given: Iris

family: Careaga

full_name: Diana Careaga

given: Diana

family: Arock

full_name: Michel Arock

given: Michel

family: Tejidor

full_name: Liliana Tejidor

given: Liliana

family: Velly

full_name: Laetitia Velly

given: Laetitia

journal_name: Critical Care

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

repository_normalized: HAL

repositories:
HAL
PubMed Central

lead_sponsor: Beckman Coulter, Inc.

location_facility: Hospital Universitari Germans Trias I Pujol


title: A Non-interventional Patient Study to Demonstrate Medical Utility of the lncRNA to Predict HF in AMI Patients

acronym: HeartLinc

summary: HeartLinc is a non-interventional patient study to demonstrate medical utility of the lncRNA to predict HF in AMI patients. 300 patients are expected to be recruited.

lead_sponsor: Firalis SA

location_country:
Korea, Republic of
France

location_facility:
SNUH
CHU de TOULOUSE


title: Le rôle de la Cryobiopsie Transbronchique Dans le Diagnostic Des Maladies Pulmoniares Interstitielles

acronym: CryoPID

summary: Pathological comparisons of surgical open lung biopsies and cryobiopsies in non-IPF ILD. Patients with non-IPF ILD eligible for an open lung biopsy will undergo cryobiopsy in the same time. Between observers agreement will be assessed for each pairs of samples.

ReferenceCitation: Romagnoli M, Colby TV, Suehs CM, Vachier I, Molinari N, Bourdin A. Cryobiopsy Compared with Surgical Lung Biopsy in ILD: Reply to Maldonado et al., Froidure et al., Bendstrup et al., Agarwal et al., Richeldi et al., Rajchgot et al., and Quadrelli et al. Am J Respir Crit Care Med. 2019 Oct 1;200(7):944-946. doi: 10.1164/rccm.201906-1252LE.

ReferenceCitation: Bourdin A, Suehs CM, Colby TV, Vachier I, Molinari N, Romagnoli M. Reply to Wand et al.: Role of Transbronchial Cryobiopsy in Interstitial Lung Diseases: An Ongoing Tale. Am J Respir Crit Care Med. 2020 Jan 15;201(2):260-261. doi: 10.1164/rccm.201909-1736LE.

ReferenceCitation: Bourdin A, Romagnoli M, Gamez AS, Hireche K, Berthet JP, Mallet JP, Vachier I, Nava S, Reynaud P, Molinari N, Suehs C. Careful consideration of the bleeding caused by transbronchial lung cryobiopsies. Eur Respir J. 2020 May 21;55(5). pii: 1902415. doi: 10.1183/13993003.02415-2019. Print 2020 May.

ReferenceType: result

ReferenceCitation: Romagnoli M, Colby TV, Berthet JP, Gamez AS, Mallet JP, Serre I, Cancellieri A, Cavazza A, Solovei L, Dell'Amore A, Dolci G, Guerrieri A, Reynaud P, Bommart S, Zompatori M, Dalpiaz G, Nava S, Trisolini R, Suehs CM, Vachier I, Molinari N, Bourdin A. Poor Concordance between Sequential Transbronchial Lung Cryobiopsy and Surgical Lung Biopsy in the Diagnosis of Diffuse Interstitial Lung Diseases. Am J Respir Crit Care Med. 2019 May 15;199(10):1249-1256. doi: 10.1164/rccm.201810-1947OC.

name: Department of Interventional Pulmonology

family: Romagnoli

full_name: Micaela Romagnoli

given: Micaela

name: Emeritus, Department of Laboratory Medicine Pathology, Mayo Clinic, Scottsdale, Arizona

family: Colby

full_name: Thomas V. Colby

given: Thomas V.

family: Berthet

full_name: Jean-Philippe Berthet

given: Jean-Philippe

family: Gamez

full_name: Anne Sophie Gamez

given: Anne Sophie

family: Mallet

full_name: Jean-Pierre Mallet

given: Jean-Pierre

family: Serre

full_name: Isabelle Serre

name: Department of Pathology, Maggiore and S’Orsola-Malpighi Hospital, Bologna, Italy

family: Cancellieri

full_name: Alessandra Cancellieri

given: Alessandra

name: Department of Pathology, Azienda USL–IRCCS, Reggio Emilia, Italy; and

family: Cavazza

full_name: Alberto Cavazza

given: Alberto

family: Solovei

full_name: Laurence Solovei

given: Laurence

family: Dell’Amore

full_name: Andrea Dell’Amore

given: Andrea

family: Dolci

full_name: Giampiero Dolci

given: Giampiero

family: Guerrieri

full_name: Aldo Guerrieri

given: Aldo

family: Reynaud

full_name: Paul Reynaud

given: Paul

name: PhyMedExp, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale, and

family: Bommart

full_name: Sébastien Bommart

given: Sébastien

name: Department of Radiology, S’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

family: Zompatori

full_name: Maurizio Zompatori

given: Maurizio

name: Department of Radiology, Bellaria Hospital, Bologna, Italy

family: Dalpiaz

full_name: Giorgia Dalpiaz

given: Giorgia

family: Nava

full_name: Stefano Nava

given: Stefano

family: Trisolini

full_name: Rocco Trisolini

given: Rocco

family: Suehs

full_name: Carey M. Suehs

given: Carey M.

family: Vachier

full_name: Isabelle Vachier

name: L’Institut Montpelliérain Alexander Grothendieck, CNRS, Centre Hospitalier Universitaire de Montpellier, University of Montpellier, Montpellier, France

family: Molinari

full_name: Nicolas Molinari

given: Nicolas

family: Bourdin

full_name: Arnaud Bourdin

given: Arnaud

journal_name: American Journal of Respiratory and Critical Care Medicine

repository_institution: Alma Mater Studiorum Università di Bologna - Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

ReferenceCitation: Suehs C, Bourdin A, Vachier I, Molinari N, Romagnoli M. Transbronchial cryobiopsy in the diagnosis of interstitial lung diseases: methodologies and perspectives from the Cryo-PID and COLDICE studies. Ann Transl Med. 2020 Oct;8(20):1330. doi: 10.21037/atm-20-2814.

ReferenceCitation: Reynaud P, Ahmed E, Serre I, Knabe L, Bommart S, Suehs C, Vachier I, Berthet JP, Romagnoli M, Vernisse C, Mallet JP, Gamez AS, Bourdin A. Club Cell Loss as a Feature of Bronchiolization in ILD. Front Immunol. 2021 Feb 26;12:630096. doi: 10.3389/fimmu.2021.630096. eCollection 2021.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

location_facility: Arnaud de Villeneuve University Hospital


title: A Double-Blind Study Evaluating the Efficacy and Safety of the Combination of Etanercept and Methotrexate in Comparison to Etanercept Alone or Methotrexate Alone in Rheumatoid Arthritis Patients.

summary: To compare the therapeutic and radiographic effects and safety between etanercept, methotrexate, and the etanercept/methotrexate combination in patients with rheumatoid arthritis.

ReferenceCitation: Gallo G, Brock F, Kerkmann U, Kola B, Huizinga TW. Efficacy of etanercept in combination with methotrexate in moderate-to-severe rheumatoid arthritis is not dependent on methotrexate dosage. RMD Open. 2016 Apr 21;2(1):e000186. doi: 10.1136/rmdopen-2015-000186. eCollection 2016.

family: Gallo

full_name: G Gallo

given: G

family: Brock

full_name: F Brock

given: F

family: Kerkmann

full_name: U Kerkmann

given: U

family: Kola

full_name: B Kola

given: B

family: Huizinga

full_name: T W J Huizinga

given: T W J

journal_name: RMD Open

license: cc-by-nc

license_normalized: cc-by-nc

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

ReferenceCitation: van der Heijde D, Klareskog L, Landewé R, Bruyn GA, Cantagrel A, Durez P, Herrero-Beaumont G, Molad Y, Codreanu C, Valentini G, Zahora R, Pedersen R, MacPeek D, Wajdula J, Fatenejad S. Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 2007 Dec;56(12):3928-39.

lead_sponsor: Wyeth is now a wholly owned subsidiary of Pfizer

location_country:
Italy
Austria
Sweden
United Kingdom
Netherlands
Spain
Finland
France
Poland
Greece
Israel
Norway
Romania
Australia
Belgium
Portugal
Denmark
Germany
Czech Republic


ReferenceCitation: Grace RF, Rose C, Layton DM, Galactéros F, Barcellini W, Morton DH, van Beers EJ, Yaish H, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Barbier AJ, Bodie S, Silver B, Hua L, Kung C, Hawkins P, Jouvin MH, Bowden C, Glader B. Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency. N Engl J Med. 2019 Sep 5;381(10):933-944. doi: 10.1056/NEJMoa1902678.

name: From the Dana–Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School, Boston (R.F.G.), and Agios Pharmaceuticals, Cambridge (A.J.B., S.B., L.H., C.K., P.H., M.-H.J., C.B.) — all in Massachusetts; Hôpital Saint Vincent de Paul, Lille (C.R.), and Unité des Maladies Génétiques du Globule Rouge, Centre Hospitalier Universitaire Henri Mondor, Créteil (F.G.) — both in France; Hammersmith Hospital, Imperial College Healthcare NHS Trust, London (D.M.L.); Fondazione IRCCS Ca’ Granda...

family: Grace

full_name: Rachael F. Grace

given: Rachael F.

family: Rose

full_name: Christian Rose

given: Christian

family: Layton

full_name: D. Mark Layton

given: D. Mark

family: Galactéros

full_name: Frédéric Galactéros

given: Frédéric

family: Barcellini

full_name: Wilma Barcellini

given: Wilma

family: Morton

full_name: D. Holmes Morton

given: D. Holmes

family: van Beers

full_name: Eduard J. van Beers

given: Eduard J.

family: Yaish

full_name: Hassan Yaish

given: Hassan

family: Ravindranath

full_name: Yaddanapudi Ravindranath

given: Yaddanapudi

family: Kuo

full_name: Kevin H.M. Kuo

given: Kevin H.M.

family: Sheth

full_name: Sujit Sheth

given: Sujit

family: Kwiatkowski

full_name: Janet L. Kwiatkowski

given: Janet L.

family: Barbier

full_name: Ann J. Barbier

given: Ann J.

family: Bodie

full_name: Susan Bodie

given: Susan

family: Silver

full_name: Bruce Silver

given: Bruce

family: Hua

full_name: Lei Hua

given: Lei

family: Kung

full_name: Charles Kung

given: Charles

family: Hawkins

full_name: Peter Hawkins

given: Peter

family: Jouvin

full_name: Marie-Hélène Jouvin

given: Marie-Hélène

family: Bowden

full_name: Chris Bowden

given: Chris

family: Glader

full_name: Bertil Glader

given: Bertil

journal_name: New England Journal of Medicine

oa_colors: green other

evidence: open (via free article)

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: Utrecht University - Utrecht University Repository

publisher: Massachusetts Medical Society

ReferenceCitation: Rab MAE, Van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, Van Straaten S, Van Solinge WW, Van Beers EJ, Kung C, Van Wijk R. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249. doi: 10.3324/haematol.2019.238865.

publisher: Ferrata Storti Foundation (Haematologica)

location_country:
Italy
Netherlands
France
United States
United Kingdom
Canada

location_facility: Wayne State University School of Medicine - Children's Hospital of Michigan

location_facility: Children Hospital of Philadelphia (CHOP)

location_facility: New York Presbyterian Hospital- Weil Cornell Medical College

location_facility: UOC Oncoematologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

title: A Phase 2, Open Label, Randomized, Dose Ranging, Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency

summary: Study AG348-C-003 is a multicenter study designed to evaluate the safety and efficacy of different dose levels of AG-348 (mitapivat) in participants with PK deficiency.


title: Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation

acronym: SOLSTICE

summary: The purpose of this study is to evaluate the safety and efficacy of cryoablation therapy used to treat tumors in participants with pulmonary metastatic disease. This study is to enroll participants who will undergo cryoablation of at least 1 metastatic pulmonary tumor that is less than or equal to 3.5 centimeter (cm). Participants will be followed 24 months post their cryoablation procedure.

ReferenceCitation: Gillams A. Lung tumour ablation - where are we now? Cancer Imaging. 2008 Apr 22;8:116-7. doi: 10.1102/1470-7330.2008.0015.

ReferenceCitation: Ahmed A, Littrup P. Percutaneous cryotherapy of the thorax: safety considerations for complex cases. AJR Am J Roentgenol. 2006 Jun;186(6):1703-6.

ReferenceCitation: Kawamura M, Izumi Y, Tsukada N, Asakura K, Sugiura H, Yashiro H, Nakano K, Nakatsuka S, Kuribayashi S, Kobayashi K. Percutaneous cryoablation of small pulmonary malignant tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates. J Thorac Cardiovasc Surg. 2006 May;131(5):1007-13.

ReferenceCitation: Asimakopoulos G, Beeson J, Evans J, Maiwand MO. Cryosurgery for malignant endobronchial tumors: analysis of outcome. Chest. 2005 Jun;127(6):2007-14.

ReferenceCitation: Wang H, Littrup PJ, Duan Y, Zhang Y, Feng H, Nie Z. Thoracic masses treated with percutaneous cryotherapy: initial experience with more than 200 procedures. Radiology. 2005 Apr;235(1):289-98.

ReferenceCitation: Inoue M, Nakatsuka S, Yashiro H, Ito N, Izumi Y, Yamauchi Y, Hashimoto K, Asakura K, Tsukada N, Kawamura M, Nomori H, Kuribayashi S. Percutaneous cryoablation of lung tumors: feasibility and safety. J Vasc Interv Radiol. 2012 Mar;23(3):295-302; quiz 305. doi: 10.1016/j.jvir.2011.11.019. Epub 2012 Jan 20.

ReferenceCitation: Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, Asakura K, Nomori H. Percutaneous cryoablation of pulmonary metastases from colorectal cancer. PLoS One. 2011;6(11):e27086. doi: 10.1371/journal.pone.0027086. Epub 2011 Nov 9.

ReferenceCitation: Pusceddu C, Sotgia B, Fele RM, Melis L. CT-guided thin needles percutaneous cryoablation (PCA) in patients with primary and secondary lung tumors: a preliminary experience. Eur J Radiol. 2013 May;82(5):e246-53. doi: 10.1016/j.ejrad.2012.12.010. Epub 2013 Feb 8.

lead_sponsor: Boston Scientific Corporation

location_country:
United States
France

location_facility: State University of New York at Stony Brook

location_facility: New York Presbyterian Hospital - Cornell Medical Center

location_facility: Cancer Treatment Centers of America at Southeastern Regional Medical Center


title: F2-PROTOCOL: Prospective Collection of Data of Possible Prognostic Relevance in Patients With Follicular Lymphoma

summary:
The F2-study is a complement of the previous studies of the Follicular Lymphoma Prognostic Factors Project which permitted the development of the Follicular Lymphoma International Prognostic Index (FLIPI).

The F2-study is designed as a prospective collection of information potentially useful to predict the prognosis of newly diagnosed Follicular Lymphoma patients, and its purposes are to validate the FLIPI and to verify whether a prognostic collection of data would allow the development of a more accurate prognostic index.

ReferenceCitation: Federico M, Bellei M, Pro B, Lopez-Guillermo A, Marcheselli L, Trneny M, Soubeyran P, MCLaughlin P, Pileri S, Solal-Céligny P on behalf of the F2 study. Revalidation of FLIPI in patients with Follicular Lymphoma (FL) registered in the F2 study and treated upfront with immunochemotherapy. J Clin Oncol 25(18s), 2007. Abstr 8008.

ReferenceCitation: Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, Vitolo U, Pro B, Martelli M, Soubeyran P, Cortelazzo S, Martinelli G, Pileri S, McLaughlin P, Solal-Céligny P on behalf of International Follicular Lymphoma Prognostic factor Project (IFLPFP) F2-study group. F2 prognostic index. Ann Oncol 19(suppl 4):101-102, 2008. Abstr 058.

ReferenceCitation: Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, Vitolo U, Pro B, Pileri S, Pulsoni A, Soubeyran P, Cortelazzo S, Martinelli G, Martelli M, Rigacci L, Arcaini L, Di Raimondo F, Merli F, Sabattini E, McLaughlin P, Solal-Céligny P. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol. 2009 Sep 20;27(27):4555-62. doi: 10.1200/JCO.2008.21.3991. Epub 2009 Aug 3.

name: From the Institutions Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Modena; Azienda Universitaria Ospedaliera S. Giovanni Battista, Torino; Istituto Seràgnoli, Unità Operativa di Emolinfopatologia, Bologna; Ematologia, Università “La Sapienza”, Roma; Ematologia e Centro Trapianto di Midollo Osseo Ospedale Centrale di Bolzano, Bolzano; Istituto Europeo di Oncologia, Milano; Cattedra di Ematologia, Università di Firenze e Azienda Ospedaliera Careggi, Firenze; Divisione di...

family: Federico

full_name: Massimo Federico

given: Massimo

family: Bellei

full_name: Monica Bellei

given: Monica

family: Marcheselli

full_name: Luigi Marcheselli

given: Luigi

family: Luminari

full_name: Stefano Luminari

given: Stefano

family: Lopez-Guillermo

full_name: Armando Lopez-Guillermo

given: Armando

family: Vitolo

full_name: Umberto Vitolo

given: Umberto

family: Pro

full_name: Barbara Pro

given: Barbara

family: Pileri

full_name: Stefano Pileri

family: Pulsoni

full_name: Alessandro Pulsoni

given: Alessandro

family: Soubeyran

full_name: Pierre Soubeyran

given: Pierre

family: Cortelazzo

full_name: Sergio Cortelazzo

given: Sergio

family: Martinelli

full_name: Giovanni Martinelli

given: Giovanni

family: Martelli

full_name: Maurizio Martelli

given: Maurizio

family: Rigacci

full_name: Luigi Rigacci

family: Arcaini

full_name: Luca Arcaini

given: Luca

family: Di Raimondo

full_name: Francesco Di Raimondo

given: Francesco

family: Merli

full_name: Francesco Merli

family: Sabattini

full_name: Elena Sabattini

given: Elena

family: McLaughlin

full_name: Peter McLaughlin

family: Solal-Céligny

full_name: Philippe Solal-Céligny

given: Philippe

journal_name: Journal of Clinical Oncology

publisher: American Society of Clinical Oncology (ASCO)

title: Follicular Lymphoma International Prognostic Index 2: A New Prognostic Index for Follicular Lymphoma Developed by the International Follicular Lymphoma Prognostic Factor Project

ReferenceCitation: Solal-Céligny P, Bellei M, Marcheselli L, Pesce EA, Pileri S, McLaughlin P, Luminari S, Pro B, Montoto S, Ferreri AJ, Deconinck E, Milpied N, Gordon LI, Federico M. Watchful waiting in low-tumor burden follicular lymphoma in the rituximab era: results of an F2-study database. J Clin Oncol. 2012 Nov 1;30(31):3848-53. doi: 10.1200/JCO.2010.33.4474. Epub 2012 Sep 24.

name: Philippe Solal-Céligny, Institut de Cancérologie de l'Ouest, Nantes/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besançon; Noël Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Università di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Seràgnoli, Università di Bologna; Andrés J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter...

title: Watchful Waiting in Low–Tumor Burden Follicular Lymphoma in the Rituximab Era: Results of an F2-Study Database

lead_sponsor: Associazione Angela Serra per la ricerca sul cancro

location_country:
Italy
Switzerland
France
Czechia
Argentina
Spain
United States
United Kingdom

location_facility: Ospedale civile Guglielmo da Saliceto - Medicina Oncologica ed Ematologica

location_facility: Hospital Universitario Vall de Hebron - Servei d'Hematologia Clinica

location_facility: Università la Sapienza, Dip. di Biotecnologie Cellulari ed Ematologia, Sez. Ematologia

location_facility: Dipartimento di Oncologia, Ematologia e Patologie dell'Apparato Respiratorio, Univ. di Modena e Reggio Emilia - Ematologia

location_facility: Istituto Scientifico Universitario San Raffaele

location_facility: Hospital Clinic - Institut d'Hematologia i Oncologia

location_facility: Dipartimento di Oncologia, Ematologia e Patologie dell'Apparato Respiratorio, Univ. di Modena e Reggio Emilia - Medicina Interna

location_facility: Azienda Ospedaliera Ospedali Riuniti Papardo-Piemonte

location_facility: Ospedale Civile SS. Giovanni e Paolo - UO di Ematologia

location_facility: Institut Bergonié Comprehensive Cancer Center

location_facility: Centre Jean Bernard, Clinique Victor Hugo

location_facility: Azienda Ospedaliera Universitaria San Giovanni Battista

location_facility: Fondazione IRCCS Policlinico San Matteo - Clinica Ematologica

location_facility: Azienda O.U. Vittorio Emanuele-Ferrarotto-S. Bambino

location_facility: Azienda Ospedaliera Universitaria Pisana - UO di Ematologia

location_facility: Centre Hospitalier Universitaire - Hématologie

location_facility: Academia Nacional de Medicina - Oncohematology Department, Instituto de Investigaciones Hematologicas

location_facility: Ospedale E. Morelli - Divisione di Medicina Generale, Ematologia

location_facility: Azienda Ospedaliera Maggiore della Carità

location_facility: Centre Hospitalier Univeristaire - Hématologie clinique

location_facility: Policlinico Universitario a gestione diretta - Divisione di Ematologia

location_facility: Centro de Internacion e Investigacion Clinica "Angelica Ocampo" - Hematologia

location_facility: Ospedale Santo Spirito, USL di Pescara - Dipartimento di Oncologia

location_facility: Hospital Universitari Germans Trias i Pujol - Institut Català d'Oncologia

location_facility: Hopital caremeau - Service de Medecine Interne B

location_facility: Charles University General Hospital - Ist Dept Medicine

location_facility: Dipartimento di Oncologia, Ematologia e Patologie dell'Apparato Respiratorio, Univ. di Modena e Reggio Emilia - Oncologia II

location_facility: Azienda Ospedaliera S. Carlo - Oncologia Medica

location_facility: Azienda Ospedaliera Sant'Andrea - UOC Ematologia

location_facility: Institu Catala d'Oncologia - Servei d'Hematologia

location_facility: Northwestern University Feinberg School of Medicine - Department of Hematology/Oncology

location_facility: Ospedale unico Versilia USL 12 - Divisione di Medicina II, DH Oncoematologico

location_facility: Ospedale Casa Sollievo della Sofferenza IRCCS

location_facility: Ospedale San Vincenzo - Ematologia e Immunologia

location_facility: Policlinico Monteluce - Divisione di Clinica Medica