summary: The purpose of this project is to study the efficacy of an anaplerotic treatment on brain energy profile evolution at an early stage of the Huntington disease.

ReferenceType: result

ReferenceCitation: Adanyeguh IM, Rinaldi D, Henry PG, Caillet S, Valabregue R, Durr A, Mochel F. Triheptanoin improves brain energy metabolism in patients with Huntington disease. Neurology. 2015 Feb 3;84(5):490-5. doi: 10.1212/WNL.0000000000001214. Epub 2015 Jan 7.

family: Adanyeguh

full_name: I. M. Adanyeguh

given: I. M.

family: Rinaldi

full_name: D. Rinaldi

given: D.

family: Henry

full_name: P.-G. Henry

family: Caillet

full_name: S. Caillet

given: S.

family: Valabregue

full_name: R. Valabregue

given: R.

family: Durr

full_name: A. Durr

given: A.

full_name: F. Mochel

given: F.

journal_name: Neurology

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health


type: Registry Identifier

title: NEw approacheS for The dIagnosis of AlzeiMer's diseAse Through neuroElectrical Changes in the Brain

acronym: ESTIMATE

summary: Recent diagnostic criteria for Alzheimer's disease (AD) recognize an extended spectrum of AD stages as part of the disease, including a preclinical stage. This underscores the importance of early prognosis of AD when it is still possible to influence the course of the disorder. The investigators propose a comprehensive project which will target the data-driven modeling of the disease development. This goal will be achieved by creating and validating a battery of new sensitive biomarkers for clinical evaluation and prediction of AD in individuals. The AD-related brain changes will be assessed by noninvasive functional EEG measured during an episodic memory task in subjects at different stages of AD, as well as in healthy controls. The novel functional biomarkers will be extracted using a rigorous multistage selection procedure involving advanced methods for feature extraction, as well as statistics and classification for optimal selection. The ESTIMATE project will serve as a first step in an extensive array of research procedures which will enable the early clinical identification of Alzheimer's disease in elderly individuals who could then take advantage of preventive pharmaceutical therapies.

study_start_date_type: Actual

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Diagnostic

enrollment_type: Actual

lead_sponsor: Institut National de la Santé Et de la Recherche Médicale, France

location_facility: Institute of Memory and Alzheimer's Disease, Pitie-Salpetriere Hospital

intervention_type: Device

lead_sponsor_type: academique

status_simplified: Completed


ReferenceType: background

ReferenceCitation: Piguet F, Sondhi D, Piraud M, Fouquet F, Hackett NR, Ahouansou O, Vanier MT, Bieche I, Aubourg P, Crystal RG, Cartier N, Sevin C. Correction of brain oligodendrocytes by AAVrh.10 intracerebral gene therapy in metachromatic leukodystrophy mice. Hum Gene Ther. 2012 Aug;23(8):903-14. doi: 10.1089/hum.2012.015. Epub 2012 Jul 23.

ReferenceCitation: Sondhi D, Johnson L, Purpura K, Monette S, Souweidane MM, Kaplitt MG, Kosofsky B, Yohay K, Ballon D, Dyke J, Kaminksy SM, Hackett NR, Crystal RG. Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Hum Gene Ther Methods. 2012 Oct;23(5):324-35. doi: 10.1089/hgtb.2012.120. Epub 2012 Nov 6.

ReferenceCitation: Colle MA, Piguet F, Bertrand L, Raoul S, Bieche I, Dubreil L, Sloothaak D, Bouquet C, Moullier P, Aubourg P, Cherel Y, Cartier N, Sevin C. Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate. Hum Mol Genet. 2010 Jan 1;19(1):147-58. doi: 10.1093/hmg/ddp475.

ReferenceCitation: i Dali C, Hanson LG, Barton NW, Fogh J, Nair N, Lund AM. Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. Neurology. 2010 Nov 23;75(21):1896-903. doi: 10.1212/WNL.0b013e3181feb217.

ReferenceType: derived

ReferenceCitation: Zerah M, Piguet F, Colle MA, Raoul S, Deschamps JY, Deniaud J, Gautier B, Toulgoat F, Bieche I, Laurendeau I, Sondhi D, Souweidane MM, Cartier-Lacave N, Moullier P, Crystal RG, Roujeau T, Sevin C, Aubourg P. Intracerebral Gene Therapy Using AAVrh.10-hARSA Recombinant Vector to Treat Patients with Early-Onset Forms of Metachromatic Leukodystrophy: Preclinical Feasibility and Safety Assessments in Nonhuman Primates. Hum Gene Ther Clin Dev. 2015 Jun;26(2):113-24. doi: 10.1089/humc.2014.139. Epub 2015 Apr 28.

name: Inserm U986, 94275 Le Kremlin Bicêtre, France.

name: Pediatric Neurosurgery, Necker Children's Hospital, 75014 Paris, France.

family: Zerah

full_name: Michel Zerah

given: Michel

sequence: first

family: Piguet

full_name: Françoise Piguet

given: Françoise

sequence: additional

name: Food Science and Engineering Oniris, Nantes-Atlantic College of Veterinary Medicine, 44000 Nantes, France.

family: Colle

full_name: Marie-Anne Colle

given: Marie-Anne

name: Service de Neurochirurgie, CHU Nord, 44000 Nantes, France.

family: Raoul

full_name: Sylvie Raoul

given: Sylvie

family: Deschamps

full_name: Jack-Yves Deschamps

given: Jack-Yves

family: Deniaud

full_name: Johan Deniaud

given: Johan

family: Gautier

full_name: Benoit Gautier

given: Benoit

name: Neuroradiologie Diagnostique et Interventionnelle, Hôpital Laennec, CHU de Nantes, 44000 Nantes, France.

family: Toulgoat

full_name: Frédérique Toulgoat

given: Frédérique

name: Faculté des Sciences Pharmaceutiques et Biologiques, 75005 Paris, France.

family: Bieche

full_name: Ivan Bieche

given: Ivan

family: Laurendeau

full_name: Ingrid Laurendeau

given: Ingrid

name: Department of Genetic Medicine, Weill-Cornell Medical College, New York, NY 10065.

family: Sondhi

full_name: Dolan Sondhi

given: Dolan

name: Neurological Surgery and Pediatrics, Weill-Cornell Medical College, New York, NY 10065.

family: Souweidane

full_name: Mark M. Souweidane

given: Mark M.

family: Cartier-Lacave

full_name: Nathalie Cartier-Lacave

given: Nathalie

name: Atlantic Gene Therapies, INSERM UMR 1089, 44000 Nantes, France.

family: Moullier

full_name: Philippe Moullier

given: Philippe

family: Crystal

full_name: Ronald G. Crystal

given: Ronald G.

name: Neurosurgery, Hôpitaux de Montpellier, 34000 Montpellier, France.

family: Roujeau

full_name: Thomas Roujeau

given: Thomas

name: Neuropediatrics Unit, Bicêtre Hospital, 94275 Le Kremlin Bicêtre, France.

family: Sevin

full_name: Caroline Sevin

given: Caroline

family: Aubourg

full_name: Patrick Aubourg

given: Patrick

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: Human Gene Therapy Clinical Development

publisher: Mary Ann Liebert Inc

publisher_dissemination: Mary Ann Liebert Inc

publisher_group: Mary Ann Liebert Inc

publisher_normalized: Mary Ann Liebert Inc

intervention_type: Genetic

status: Unknown status

enrollment_type: Anticipated

primary_purpose: Treatment

acronym: TG-MLD

study_completion_date_type: Anticipated

type: EudraCT Number

source: euctr

title: A Phase I/II, Open Labeled, Monocentric Study of Direct Intracranial Administration of a Replication Deficient Adeno-associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human ARSA cDNA to Children With Metachromatic Leukodystrophy.

summary:
The objective of this open-label, single arm, monocentric, phase I/II clinical study is to assess safety and efficacy of ARSA gene transfer in the brain of children affected with early onset forms of Metachromatic Leukodystrophy (MLD). For this purpose, an adeno-associated virus serotype rh.10 (AAVrh.10) vector will be used to transfer the ARSA cDNA coding for Arylsulfatase A (ARSA) enzyme into the brain of children. Five patients with early onset form of MLD, age ranging from 6 months to 4 years, will be included in this protocol and will be followed during 24 months.

Patients will be selected at presymptomatic or early stage of their disease, following clinical, neuropsychological and brain imaging criteria.

Twelve simultaneous injections of the investigational medicinal product will be performed in the white matter of both brain hemispheres, through 6 image-guided tracks, with 2 deposits per track.

A low dose (1x10EXP12 vg total) will be administered to the first 2 patients, while the last 3 will receive a higher dose (4x10EXP12 vg total).

Safety and efficiency will be evaluated based on clinical, neuropsychological, radiological, electrophysiological and biological parameters.

status_simplified: Unknown


title: Discovery of the Risk Factors Associated to the Development of Vasospasm Following a Sub-arachnoid Aneurismal Hemorrhage Via Genomic Studies Including Genetic and Transcriptomic

summary:
Rational: The main danger with intracranial aneurism is its rupture conjugated with subarachnoid hemorrhage (SAH) occurrence. SAH is a severe pathology leading not only to neurological but also extra cerebral disorders. The major cause of morbidity and mortality when developing a SAH is the secondary development of a delayed cerebral ischemia consecutive to a prolonged vasospasm of cerebral arteries. The understanding of the pathophysiological mechanisms of SAH complication, such as vasospasm which is the more frequent, is essential.

Vasospasm is defined as a reversible shrinking of an artery lumen diameter in the subarachnoid space, beginning generally between 4 and 12 days after the hemorrhage. Such a vasospasm could have a huge clinical impact leading to delayed neurological ischemic deficiency in 17 to 40 % of cases. Up to day, mechanisms involved in vasospasm occurrence are not well described.

Disposing of well-established genetics and transcriptomics databases along with cerebral ischemia and inflammation is essential to unravel the mechanisms leading to vasospasm occurrence on SAH patients. It will enable researchers to better comprehend SAH pathology and elaborate an efficient and individualized therapeutic strategy to SAH acute phase in order to reduce the risk of vasospasm occurrence.

Aims: 1) Constitute DNA and RNA Biobank via blood proofing oh SAH patients 2) Constitute a database grouping clinical and biological data 3) Look for genetic and transcriptomic early markers via genomic approaches 4) Correlate these different markers with vasospasm occurrence and clinical evolution of the patients

Study: Patients inclusion will be done following their admission (D1) in the " unité de réanimation neurochirurgicale" of Pitié-Salpètrière Hospital. After obtaining of the informed consent, blood proofing will be realized daily during 12 days: one daily 2.5ml tube for the transcriptomic study and a single 10ml EDTA tube for genetic analyses. Clinical and biological follow-up will be performed as usual.

200 patients will be initially included during 2 to 3 years for the transcriptomic study of which 1/3 will develop vasospastic complication. The transcriptomic study will thus be performed by comparing patients developing or not developing this complication

Expected Results: Unravel vasospasm early genetic markers.

study_type: Observational

time_perspective: Prospective

ReferenceCitation: Pulcrano-Nicolas AS, Proust C, Clarençon F, Jacquens A, Perret C, Roux M, Shotar E, Thibord F, Puybasset L, Garnier S, Degos V, Trégouët DA. Whole-Blood miRNA Sequencing Profiling for Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage. Stroke. 2018 Sep;49(9):2220-2223. doi: 10.1161/STROKEAHA.118.021101.

name: From the INSERM UMR-S 1166 (A.-S.P.-N., C. Proust, C. Perret, M.R., F.T., S.G., D.-A.T.)

name: Sorbonne Universités, University Pierre et Marie Curie, Université Paris 06, France; ICAN Institute of Cardiometabolism and Nutrition, Paris, France (A.-S.P.-N., C. Proust, C. Perret, M.R., F.T., S.G., D.-A.T.)

family: Pulcrano-Nicolas

full_name: Anne-Sophie Pulcrano-Nicolas

given: Anne-Sophie

family: Proust

full_name: Carole Proust

given: Carole

name: Groupe de Recherche Clinique Biosfast (F.C., E.S.)

name: Department of Neuroradiology (F.C., E.S.)

family: Clarençon

full_name: Frédéric Clarençon

given: Frédéric

name: Department of Anesthesia and Intensive Care (A.J., L.P., V.D.)

name: Pitié-Salpetrière Hospital, Assistance Publique-Hopitaux de Paris, France; and INSERM UMR 1141, Université Paris 7, France (A.J., L.P., V.D.).

family: Jacquens

full_name: Alice Jacquens

given: Alice

family: Perret

full_name: Claire Perret

given: Claire

family: Roux

full_name: Maguelonne Roux

given: Maguelonne

family: Shotar

full_name: Eimad Shotar

given: Eimad

family: Thibord

full_name: Florian Thibord

given: Florian

family: Puybasset

full_name: Louis Puybasset

given: Louis

family: Garnier

full_name: Sophie Garnier

given: Sophie

family: Degos

full_name: Vincent Degos

given: Vincent

family: Trégouët

full_name: David-Alexandre Trégouët

given: David-Alexandre

journal_name: Stroke

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via free pdf)

host_type: publisher

license_normalized: no license

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repository_normalized: HAL

version: submittedVersion

publisher: Ovid Technologies (Wolters Kluwer Health)

location_facility: Neuro-anesthesia intensive care unit, Pitié-Salpétrière hospital


title: Non Invasive IDentification of Gliomas With IDH1 Mutation by Free Plasmatic DNA Analysis, 2-hydroxyglutarate Dosage in the Urines and 2-hydroxyglutarate Detection by Brain SPEctro-MRI: Diagnostic and Follow-up Application (IDASPE)

acronym: IDASPE

summary:
The recurrent mutation IDH1Arg132His leads to the cellular accumulation of D-2-hydroxyglutarate (2-HG), thus representing a diagnostic marker (this change is almost specific for gliomas) and prognostic (mutated gliomas have longer survival) of interest.

The main objective is to identify the patients with IDH1 mutated glioma by three complementary approaches -genetic (identification of IDH1 mutation in plasmatic DNA), biochemical (2-HG dosage in the urine of patients) and radiological (2-HG

location_facility: GH Pitié-Salpêtrière, 47 Bd de l'Hopital,


title: Molecularly Imprinted Polymer Sensors of Modified Nucleosides for Non-invasive Monitoring of Cancer Therapy : Effect of Chemotherapy on Cancerous Proliferation Based on the Dynamic Excretion of Urinary Nucleosides.

summary: Observational, non randomized study aimed at measuring the effect of chemotherapy in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer.


title: Molecularly Imprinted Polymer Sensors of Modified Nucleosides for Non-invasive Monitoring, of Cancer Therapy: Impact of Surgical Resection of Metastasis on Urinary Excretion of Modified Nucleosides.

summary: Observational, non randomized study aimed at measuring the effect of surgical resection of metastasis in the urinary concentrations of physiological modified nucleosides in 45 patients with metastatic colorectal cancer.


title: L'Apathie Dans la schizophrénie: étude Neuropsychologique et Anatomique

summary:
Apathy, defined as a quantitative reduction of voluntary, goal-directed behaviours (GDB), is a core component of negative symptoms. It has been suggested that the physiopathology of apathy is not a single entity but may be multiple, depending on which specific process or macrofunction is disrupted during completion of GDB. In line with this notion, Levy and Dubois proposed dividing apathic syndromes into three subtypes of disrupted processing: 'a-motivation', 'cognitive inertia', and 'uncoupling'. In schizophrenia, apathy has been associated with executive dysfunction, functional impairment and poor outcome. However, the neurobiological underpinnings of apathy in schizophrenia are poorly understood.

Primary objective: confirm that chronic schizophrenic patients are apathic compared to healthy volunteers

Secondary objectives:

investigate if apathy is related to a particular aspect of the disease (i.e. negative, positive symptomatology and/or deficit form)
investigate if apathy correlates with executive dysfunction
investigate if apathy is associated with a specific mechanism using an experimental task specially designed to investigate the different mechanism (i.e. 'a-motivation', 'cognitive inertia', and 'uncoupling')
investigate if there is a volumetric abnormality affecting the executive system in apathic schizophrenic patients
link these eventual volumetric abnormalities to prefrontal cortex-basal ganglia circuits according to a specific subtype of apathy in the apathic schizophrenic group

time_perspective: Cross-Sectional

location_facility: INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière


title: Methodological Study of Synaptic Plasticity Imaging With Diffusion MRI

summary: Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique. The researchers investigated these rapid synaptic plasticity changes with visual activation followed by BOLD and diffusion functional MRI as well as anatomical (venography, tractography by diffusion) features in young and aged subjects.

time_perspective: Retrospective


title: Social Interactions: Ocular Explorations and Pupillometry in Autism

acronym: ISEOP

summary:
The primary objective of this work will first to characterize in typical childhood, visual exploratory behavior and pupillary response associated with salience of human social stimuli (faces and body movements), and then to evaluate these markers in children with autism.

The second objective of this work will be to achieve in a population of children with autism a longitudinal evaluation of these markers during development and therapeutics.


title: Description Des Populations Cellulaires Des Tissus Adipeux Sous-cutanés Abdominaux et glutéo-fémoraux Chez la Femme.

summary:
The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.

The findings of this study may help to explain the mechanism contributing to a beneficial role of gluteo-femoral fat contrasting with a deleterious role of abdominal fat on cardiovascular and metabolic dysfunctions.

primary_purpose: Basic Science

location_facility: Centre d'Investigation Clinique, CHU Purpan

intervention_type: Procedure


title: Analyse Fonctionnelle Par Imagerie Dynamique de l'épithélium Respiratoire Chez Des Nourrissons Atteints de Mucoviscidose

summary: Cystic fibrosis (CF) is characterized by airway inflammation and infection leading to progressive destruction of lungs. One of the most important abnormalities in CF is an abnormal processing of the mutated CFTR protein through the endoplasmic reticulum that causes abnormal location or even absence of the protein at the apical plasma membrane of airway epithelial cells. This abnormality results in a marked dehydration of the airway surface fluid, decreased mucus transport and airway obstruction. Nevertheless, the events that occur very early during the progression of the disease at the airway level in infants are not known. At cellular level, it has also been reported that the CFTR expression and localization could be related to the differentiation state of the airway epithelium. Furthermore, it has been reported that gap junctions could be involved in dysregulate inflammation process. In CF infants, many answers are still lacking. For a better understanding of the early stages of cystic fibrosis, it is of major interest to study respiratory epithelial cells obtained as early as possible. In 15 CF infants and 15 control infants, a nasal brushing will be performed by means of a soft sterile cytology brush. Samples will be used for cytological and functional studies: ciliary beating frequency, cAMP-dependent chloride efflux, potassium efflux, tight and gap junctions functionalities. These studies will be done in basal conditions and will be repeated after activation of the nasal epithelial cells by the bacteria, such as Staphylococcus aureus, which can be found very early in the course of CF disease.

ReferenceCitation: Mosler K, Coraux C, Fragaki K, Zahm JM, Bajolet O, Bessaci-Kabouya K, Puchelle E, Abély M, Mauran P. Feasibility of nasal epithelial brushing for the study of airway epithelial functions in CF infants. J Cyst Fibros. 2008 Jan;7(1):44-53. Epub 2007 Jun 5.


title: Spatio-temporal Dynamic of the Relationship Between Spatial Attention and Visual Awareness

summary:
The tight relationship between attention and conscious perception makes them difficult to study in isolation and has led many scientists to closely link these two processes. However, while some authors argue that conscious perception cannot occurs without attention, magnetoencephalography (MEG) and fMRI studies had shown that attention and consciousness are two distinct brain processes.

If endogenously triggered attention and consciousness are dissociated, it has been proposed that orienting of exogenous attention is a necessary, though not sufficient, antecedent of conscious perception.

In the present study we used MEG to explore the neural correlates of exogenous attention and consciousness during visual processing.


title: Thérapeutique expérimentale du Tremblement Essentiel Par la Stimulation Trans-crânienne Par Courant Direct (tDCS) du Cortex cérébelleux et du Cortex Moteur. Etude Exploratoire.

acronym: ELECTRE

summary: The purpose of this study is to determine whether transcranial direct current stimulation (tDCS) delivered over the motor cortex or the cerebellum can improve essential tremor and to identify the cerebral mechanisms involved in these potential effects.

location_facility: Institut du Cerveau et de la Moelle, Hôpital Pitié-Salpétrière


title: Evaluation de la Spironolactone Dans le Traitement Des choriorétinites séreuses Centrales Non résolutives à Trois Mois

summary:
The objective of the study is to evaluate the effect of spironolactone on 16 patients presenting with chronic non-resolutive central serous chorioretinitis (CSCR) and to evaluate whether spironolactone can resolve sub retinal fluid in these patients.

CSCR is a major cause of visual loss in the young population. It is characterized by sub retinal fluid under the retina and retinal pigment epithelial detachments. The exact causes of the disease remain unknown but a choroidopathy has been suggested. Moreover, corticotherapy and stress are known risk factors of CSCR.

Our preclinical studies have demonstrated that the mineralocorticoid pathway could be involved in the control of choroidal blood flow.

The investigators propose to evaluate the mineralocorticoid receptors antagonist spironolactone in the treatment of CSCR.

Criteria of efficacy Endpoint: reduction of subretinal fluid ≥ 40 microns Secondary endpoint: visual acuity gain ≥ 15 EDTRS letters

intervention_type: Drug


title: Observational, Follow-up Study of Adaptive Optics Retinal Imaging in Controls and During Retinal or General Diseases

acronym: iPhot

summary: Using an adaptive optics imaging device, retinal structures are observed in healthy and diseased subjects.

ReferenceCitation: Paques M, Meimon S, Rossant F, Rosenbaum D, Mrejen S, Sennlaub F, Grieve K. Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases. Prog Retin Eye Res. 2018 Sep;66:1-16. doi: 10.1016/j.preteyeres.2018.07.001. Epub 2018 Jul 17. Review.

family: Paques

full_name: Michel Paques

given: Michel

family: Meimon

full_name: Serge Meimon

given: Serge

family: Rossant

full_name: Florence Rossant

given: Florence

family: Rosenbaum

full_name: David Rosenbaum

given: David

family: Mrejen

full_name: Sarah Mrejen

given: Sarah

family: Sennlaub

full_name: Florian Sennlaub

family: Grieve

full_name: Kate Grieve

given: Kate

journal_name: Progress in Retinal and Eye Research

oa_host_type: repository

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

ReferenceCitation: Miloudi C, Rossant F, Bloch I, Chaumette C, Leseigneur A, Sahel JA, Meimon S, Mrejen S, Paques M. The Negative Cone Mosaic: A New Manifestation of the Optical Stiles-Crawford Effect in Normal Eyes. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7043-50. doi: 10.1167/iovs.15-17022.

name: Quinze-Vingts Hospital Departement Hospitalo-Universitaire SightMaintain, Institut National de la Recherche Medicale (INSERM)–Direction de l'Hospitalisation et de l'Organisation des Soins CIC 1423, Paris, France 2Alten Corporation, Boulogne Billancourt, F

family: Miloudi

full_name: Chahira Miloudi

given: Chahira

name: Institut Supérieur d'Electronique de Paris, Paris, France

name: Institut Mines Telecom, Telecom ParisTech, Centre National de la Recherche Scientifique Laboratoire Traitement et Communication de l'Information, Paris, France

family: Bloch

full_name: Isabelle Bloch

given: Isabelle

family: Chaumette

full_name: Céline Chaumette

given: Céline

family: Leseigneur

full_name: Alexandre Leseigneur

given: Alexandre

family: Sahel

full_name: José-Alain Sahel

given: José-Alain

name: Office National d'Etudes et de Recherches Aéronautiques, Châtillon, France

journal_name: Investigative Opthalmology & Visual Science

publisher: Association for Research in Vision and Ophthalmology (ARVO)

ReferenceCitation: Jacob J, Krivosic V, Paques M, Tadayoni R, Gaudric A. CONE DENSITY LOSS ON ADAPTIVE OPTICS IN EARLY MACULAR TELANGIECTASIA TYPE 2. Retina. 2016 Mar;36(3):545-51. doi: 10.1097/IAE.0000000000000737.

family: Jacob

full_name: Julie Jacob

ReferenceCitation: Paques M, Miloudi C, Kulcsar C, Leseigneur A, Chaumette C, Koch E. High-resolution imaging of gunn's dots. Retina. 2015 Jan;35(1):120-4. doi: 10.1097/IAE.0000000000000269.

title: HIGH-RESOLUTION IMAGING OF GUNN'S DOTS

ReferenceCitation: Errera MH, Coisy S, Fardeau C, Sahel JA, Kallel S, Westcott M, Bodaghi B, Paques M. Retinal vasculitis imaging by adaptive optics. Ophthalmology. 2014 Jun;121(6):1311-2.e2. doi: 10.1016/j.ophtha.2013.12.036. Epub 2014 Feb 25.

title: Retinal Vasculitis Imaging by Adaptive Optics

ReferenceCitation: Koch E, Rosenbaum D, Brolly A, Sahel JA, Chaumet-Riffaud P, Girerd X, Rossant F, Paques M. Morphometric analysis of small arteries in the human retina using adaptive optics imaging: relationship with blood pressure and focal vascular changes. J Hypertens. 2014 Apr;32(4):890-8. doi: 10.1097/HJH.0000000000000095.

ReferenceCitation: Gocho K, Sarda V, Falah S, Sahel JA, Sennlaub F, Benchaboune M, Ullern M, Paques M. Adaptive optics imaging of geographic atrophy. Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3673-80. doi: 10.1167/iovs.12-10672.

journal_name: Investigative Ophthalmology & Visual Science

title: Adaptive Optics Imaging of Geographic Atrophy


title: Imagerie 3D d'élasticité du Sein Par échographie Ultrarapide au Cours d'un Traitement Par chimiothérapie néoadjuvante.

summary: Breast Ultrasound Elastography is a complementary technique permitting a better characterization of breast lesions. 3D breast ultrasound elastography is a novel technique permitting a volumetric calculation of lesion stiffness. This could be particularly useful in patients with large breast tumors under pre-operative chemotherapy

ReferenceCitation: Athanasiou A, Tardivon A, Tanter M, Sigal-Zafrani B, Bercoff J, Deffieux T, Gennisson JL, Fink M, Neuenschwander S. Breast lesions: quantitative elastography with supersonic shear imaging--preliminary results. Radiology. 2010 Jul;256(1):297-303. doi: 10.1148/radiol.10090385. Epub 2010 May 26.


title: Accelerated Aging of the Cells of Visceral Adipose Tissue in Morbid Obese Subjects: Involvement in Diseases Associated With Obesity (Viellissement accéléré Des Cellules du Tissu Adipeux viscéral Chez Les obèses Morbides: Implication Dans Les Pathologies associées à l'obésité)

acronym: SENAPID

summary:
Numerous epidemiological studies clearly showed the relationship between the excessive growth of visceral adipose tissue and risk of developing insulin resistance, type 2 diabetes and other cardiovascular risk factors. However, the mechanisms contributing to the deleterious role of visceral adipose tissue remain to be elucidated. Several observations suggest that adipose tissue depots exhibit distinct metabolic and secretory capacities according to their locations. We have recently shown that visceral fat depots display higher immuno-inflammatory cells infiltration than that of subcutaneous fat. In addition, the endothelial cells of visceral compared to subcutaneous adipose tissues express a pro-inflammatory phenotype and several markers related to aging. Finally, we have shown that visceral adipocyte-derived secretions promote the endothelial cell senescence in an extent higher than subcutaneous adipocyte-derived products. These data suggest that senescence 1) might be a phenomenon related to the location and therefore the microenvironment of adipose tissue and 2) might be responsible for an abnormal activation of proinflammatory response, favouring the development of metabolic and secretory dysfunction of adipose tissue in obesity. Our working hypothesis, based on these observations, is that the visceral adipose tissue provides a microenvironment that promotes accelerated aging. This senescence may be responsible for the establishment of an inflammatory reaction, alteration of the metabolic activity and adipocyte differentiation capacity of progenitor cells leading to the development of obesity associated diseases.

The proposed project is a descriptive cross-sectional pathophysiological study .The aims are 1) to better define the process of senescence in human adipose tissue, 2) to precise the mechanisms and 3) to analyse the cellular and functional consequences of aging on inflammation, adipose tissue development and metabolism. 200 morbidly obese candidates for bariatric surgery will be studied. The collection of clinical and laboratory data and the collection of biological samples (plasma, blood cells and subcutaneous and visceral adipose tissues) will be made at the inclusion and during surgery (obesity center, Hôpital Louis Mourier). Analyses of adipose tissue will be performed at INSERM U1048 and will focus on in vitro approaches of the cells of the adipose tissues (mature adipocytes, endothelial cells, progenitor cells and immuno-inflammatory cells).

This project will permit to better understand the pathogenicity associated with the excessive growth of visceral adipose tissue and may reveal new therapeutic targets to limit obesity-associated pathologies.


title: Evaluation de l'efficacité de la Galantamine Versus Placebo associée à Une Revalidation Neuropsychologique Chez Des Patients présentant un Trouble Cognitif après un Premier Infarctus cérébral : étude en Neuroimagerie Fonctionnelle

acronym: COGICRehab

summary:
The investigators would like to conduct a double blind placebo-controlled prospective study to show the impact of a treatment combining a specific cognitive rehabilitation program and acetylcholinesterase inhibitors on executive function of young patients 3 months after a first symptomatic stroke. The secondary objectives will be to assess cognitive changes performance (executive but also non trained functions such as memory) before and after treatments and treatment effect on activity of daily living and on quality of life.

The main objective of this study is to show the impact of this combined treatment on brain activation maps in VCI-ND patients in the post-acute phase (3 months) after a stroke. Treatment effect will be assessed by functional MRI (fMRI) while patients will be performing a specific executive task.

The investigators hypothesize that the specific rehabilitation associated with acetylcholinestrase inhibitors treatment will focalize cerebral activation observed in fMRI, improve executive functions specifically, improve non trained cognitive functions (generalization effect).

location_facility: Service de Neurologie, CHU Toulouse Purpan


title: EG-VEGF (Endocrine Gland-derived Vascular Endothelial Growth Factor) in Normal and Pathological Pregnancies: Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction

acronym: EGEVE

summary: The purpose of this study is to assess the potential prognostic value of seric concentrations of EG-VEGF for Pre-eclampsia and/or intrauterine growth restriction and will allow checking whether plasma levels of EG-VEGF at 14-18 weeks of gestation could be proposed as prognostic marker for preeclampsia.

primary_purpose: Other

ReferenceCitation: Hoffmann P, Feige JJ, Alfaidy N. Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation. Placenta. 2007 Oct;28(10):1049-58. Epub 2007 May 25.

ReferenceCitation: Hoffmann P, Feige JJ, Alfaidy N. Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy. Endocrinology. 2006 Apr;147(4):1675-84. Epub 2005 Dec 29.

ReferenceCitation: Hoffmann P, Saoudi Y, Benharouga M, Graham CH, Schaal JP, Mazouni C, Feige JJ, Alfaidy N. Role of EG-VEGF in human placentation: Physiological and pathological implications. J Cell Mol Med. 2009 Aug;13(8B):2224-2235. doi: 10.1111/j.1582-4934.2008.00554.x.

name: Institut National de la Santé et de la Recherche Médicale, Grenoble, France

name: Commissariat à l’Energie Atomique, iRTSV, Grenoble, France

name: Université Joseph Fourier, Grenoble, France

name: Centre Hospitalier Régional Universitaire de Grenoble, Département de Gynécologie, Obstétrique et Médecine de la Reproduction, Grenoble, France

family: Hoffmann

full_name: Pascale Hoffmann

given: Pascale

family: Saoudi

full_name: Yasmina Saoudi

given: Yasmina

name: Centre National de la Recherche Scientifique, Grenoble, France

family: Benharouga

full_name: Mohamed Benharouga

given: Mohamed

name: Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada

family: Graham

full_name: Charles H. Graham

given: Charles H.

family: Schaal

full_name: Jean‐Patrick Schaal

given: Jean‐Patrick

name: Département de Gynécologie, Obstétrique, Hôpital de la Conception, Marseille, France

family: Mazouni

full_name: Chafika Mazouni

given: Chafika

family: Feige

full_name: Jean‐Jacques Feige

given: Jean‐Jacques

family: Alfaidy

full_name: Nadia Alfaidy

given: Nadia

currency_apc_doaj: USD

journal_name: Journal of Cellular and Molecular Medicine

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

title: Role of EG‐VEGF in human placentation: Physiological and pathological implications

location_facility: Clinical investigation center of the Grenoble University Hospital

intervention_type: Other


intervention_type: Biological

status: Terminated

primary_purpose: Prevention

acronym: EVAD

location_facility: Service d'Immunologie Clinique Hôpital Henri Mondor

title: Randomised, Multicentric, Phase ii Study of the Immunogenicity of a "Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency

summary: The main objective of this study is to evaluate and to compare the specific antibody response to a " prime-boost " vaccine strategy combining the seven valence pneumococcal conjugate vaccine (PnCj) prime at W0 followed by the administration of the pneumococcal capsular polysaccharide vaccine (PPS) boost at W4, to the administration of the pneumococcal capsular polysaccharide vaccine (PPS) alone at W4 in patients with common variable immunodeficiency.


title: Effect of Curcumin on Iron Metabolism in Healthy Volunteer

acronym: CURHEP

summary: The purpose of this study is to determine the impact of curcumin, administrated orally, on iron metabolism in healthy volunteers. Iron metabolism will be describe by hepcidin expression that the investigators observed in vitro and serum hepcidin levels.

ReferenceCitation: Fatih N, Camberlein E, Island ML, Corlu A, Abgueguen E, Détivaud L, Leroyer P, Brissot P, Loréal O. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med (Berl). 2010 May;88(5):477-86. doi: 10.1007/s00109-009-0588-3. Epub 2010 Feb 19.

ReferenceCitation: Loréal O, Haziza-Pigeon C, Troadec MB, Detivaud L, Turlin B, Courselaud B, Ilyin G, Brissot P. Hepcidin in iron metabolism. Curr Protein Pept Sci. 2005 Jun;6(3):279-91. Review.

ReferenceCitation: Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007 Jan 1;109(1):353-8. Epub 2006 Aug 31.

ReferenceCitation: Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ, Steward WP. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004 Oct 15;10(20):6847-54.

ReferenceCitation: Vareed SK, Kakarala M, Ruffin MT, Crowell JA, Normolle DP, Djuric Z, Brenner DE. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1411-7. doi: 10.1158/1055-9965.EPI-07-2693.

location_facility: Centre d'Investigation Clinique (CIC) , 2 rue Henri Le Guilloux , CHU Pontchaillou


title: Evaluation and Comparison of Cerebral Activities Modifications Associated With Two Different Cognitive and Behavioral Therapies for Obsessive Compulsive Disorder Patients

acronym: TOC TOC

summary:
Obsessive compulsive Disorder (OCD) is a frequent psychiatric disorder. Obsessions and compulsions are the two manifestations of this disease. Obsessions are recurrent anxious ideas, and compulsions repetitive behavior aiming to decrease this anxiety.

OCD symptoms have been associated with cortical and sub-cortical dysfunctions and more precisely an hyperactivity of prefrontal cortex / basal ganglia loops.

Functional neuro-imagery studies have shown a significant decrease of orbito-frontal cortex, anterior cingulate cortex, caudate nucleus and cerebellum activities after two OCD reference treatments : medication and Cognitive and Behavioral Therapy (CBT).

Two groups of 20 patients are included in this study and follow a CBT for 15 sessions. They are randomised in two groups : one proposing a "reference CBT", the other associate CBT to a new psychopedagogic task developed by the investigators team.

Clinical investigations and neuro-imagery data are collected at the main steps of therapies : before, during (half-therapy), at the end of therapies and 6 month later. Symptoms severity, patients and relatives quality of life are also assessed.

design_allocation: Non-Randomized

intervention_type: Behavioral


title: Structural and Functional Connectivity in Partial Epilepsies Studied With MRI and MEG

summary:
Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated focus but surgical benefits are less clear for patients with a poorly defined focus such as non lesional refractory partial epilepsies.

SEEG is considered the criterion standard to localize the epileptogenic zone (EZ) but the procedure is risky with a limited spatial sampling. The development of non-invasive neuroimaging alternatives is thus an important goal to improve EZ delineation and optimize SEEG procedures.

The main hypothesis of this research project is the existence of a network organization specific for each patient which allows the generation and propagation of epileptic activities. The investigators wish to explore this network using diffusion tensor MRI to study structural connectivity and MEG/FMRI to study functional connectivity. The investigators will apply tools from the theories of complex networks and dynamical systems to characterize the network organization of epileptic process.

The investigators aimed to identify and localize differences in connectivity parameters between individual patients and a control group of healthy volunteers.

ReferenceCitation: Chavez M, Valencia M, Navarro V, Latora V, Martinerie J. Functional modularity of background activities in normal and epileptic brain networks. Phys Rev Lett. 2010 Mar 19;104(11):118701. Epub 2010 Mar 18.


title: Long-term Outcome and Lung Capacity in Survivors of ARDS Due to Influenza A (H1N1) v2009 The RESPIFLU Study

acronym: RESPIFLU

summary:
Influenza A (H1N1) v2009 infection was responsible throughout the world of viral pneumonia and severe pulmonary edema requiring rescue therapeutics such as extracorporeal oxygenation. To date, no data exist on the outcome of patients having developed acute respiratory distress syndrome (ARDS) due to influenza A (H1N1) v2009, and in particular in patients with very severe lung injury requiring extracorporeal oxygenation. Although data exist on long-term outcome of survivors of ARDS, the patients included in the observational studies were heterogeneous with various underlying disease. Moreover, no study compared the outcome of survivors of ARDS according to the need or not of extracorporeal oxygenation. We therefore conducted this prospective case-control study to compare the long term pulmonary and extra pulmonary function in 2 groups of patients, one with severe ARDS due to H1N1 requiring extracorporeal oxygenation (case), and the second with ARDS due to H1N1 but without need for extracorporeal oxygenation (control). Eighteen case patients with inclusion and without non-inclusion criteria were selected from our national registry, and 32 controls (with inclusion and exclusion criteria) were matched on age, sex, and body mass index. All 48 patients will be contacted and asked to participate. Patients will be evaluate at least 9 months after ICU discharge, looking for health-related quality of life, measured by the Medical Outcomes Study 36-item Short-Form General Health Survey (SF-36), post traumatic stress disorder, assessed by the Impact of Event Scale Anxiety, and depression, assessed by the Hospital and Depression Score. Pulmonary function testing, including VO2 max test on a static bike will be performed. Muscle weakness will be clinically evaluated by the medical council research (MRC) test, with an additional electromyography if the result of the test was <48/60. A CT-scan will be performed, looking for lung abnormalities (fibrosis...). Albumin and prealbumin will be measured to evaluate the nutritional status.

Primary outcome measurement is carbon monoxide diffusion capacity. The primary hypothesis is that patients with extracorporeal oxygenation will have a carbon monoxide diffusion capacity lower than patients without extracorporeal oxygenation (15% difference between groups). Inclusion of 13 patients in the case group and 26 patients in the control group will allow testing this hypothesis with a statistical power of 80% (standard deviation 15%). Secondary outcome measures will be the quality of life, the presence or not of post-traumatic stress disorders, of anxiety and/or depression, the results of pulmonary function testing, of the CT-scan, and of muscle testing. All results will be compared in patients with and without extracorporeal oxygenation.

ReferenceCitation: Luyt CE, Combes A, Becquemin MH, Beigelman-Aubry C, Hatem S, Brun AL, Zraik N, Carrat F, Grenier PA, Richard JM, Mercat A, Brochard L, Brun-Buisson C, Chastre J; REVA Study Group. Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS. Chest. 2012 Sep;142(3):583-592. doi: 10.1378/chest.11-2196.

family: Luyt

full_name: Charles-Edouard Luyt

given: Charles-Edouard

family: Combes

full_name: Alain Combes

given: Alain

family: Becquemin

full_name: Marie-Hélène Becquemin

given: Marie-Hélène

family: Beigelman-Aubry

full_name: Catherine Beigelman-Aubry

given: Catherine

family: Hatem

full_name: Stéphane Hatem

given: Stéphane

family: Brun

full_name: Anne-Laure Brun

given: Anne-Laure

family: Zraik

full_name: Nizar Zraik

given: Nizar

family: Carrat

full_name: Fabrice Carrat

given: Fabrice

family: Grenier

full_name: Philippe A. Grenier

given: Philippe A.

family: Richard

full_name: Jean-Christophe M. Richard

given: Jean-Christophe M.

family: Mercat

full_name: Alain Mercat

family: Brochard

full_name: Laurent Brochard

given: Laurent

family: Brun-Buisson

full_name: Christian Brun-Buisson

given: Christian

family: Chastre

full_name: Jean Chastre

given: Jean

journal_name: Chest

title: Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS


title: Type 2 Diabetes Secondary Prevention Trial at the Reunion Island

summary: Three hundred and ninety height diabetic patients were educated during a week of hospitalisation (nutritional and physical-activity advices). After that, they were randomized in two groups : frequent follow-up (each three month) by educational nurses and dieteticians, versus no follow-up (control group). All patients were evaluated one year after their inclusion,by HbA1c (primary outcome), anthropometry, other cardiovascular risk factors, nutritionnal and physical-activity behaviours.

ReferenceCitation: Debussche X, Rollot O, Le Pommelet C, Fianu A, Le Moullec N, Régnier C, Boyer MC, Cogne M, Bakiri F, Schwager JC, Favier F. Quarterly individual outpatients lifestyle counseling after initial inpatients education on type 2 diabetes: the REDIA Prev-2 randomized controlled trial in Reunion Island. Diabetes Metab. 2012 Feb;38(1):46-53. doi: 10.1016/j.diabet.2011.07.002. Epub 2011 Oct 24.

family: Debussche

full_name: X. Debussche

given: X.

family: Rollot

full_name: O. Rollot

given: O.

family: Le Pommelet

full_name: C. Le Pommelet

given: C.

family: Fianu

full_name: A. Fianu

given: A.

family: Le Moullec

full_name: N. Le Moullec

given: N.

family: Régnier

full_name: C. Régnier

family: Boyer

full_name: M.C. Boyer

family: Cogne

full_name: M. Cogne

given: M.

family: Bakiri

full_name: F. Bakiri

given: F.

family: Schwager

full_name: J.C. Schwager

family: Favier

full_name: F. Favier

journal_name: Diabetes & Metabolism

title: Quarterly individual outpatients lifestyle counseling after initial inpatients education on type 2 diabetes: The REDIA Prev-2 randomized controlled trial in Reunion Island


title: Pharmacokinetic of Ten Parent Drugs and Their Metabolits in Order to Characterise Individual Metabolic Profile

summary: The study aims to descibe the pharmacokinetics of 10 substrates of enzymes involved in drug metabolism and their metabolites, after administration singly and simultaenously at predefined doses in 10 health volunteers.


type: Other Identifier

title: Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction

acronym: INSTIN

summary:
Erectile dysfunction is a frequent adverse event after radical prostatectomy for prostate cancer.

It is the consequence of penile vascular damage, mainly arterial insufficiency and venous leakage associated with fibrosis of the corpus cavernous. Apoptosis of penile cells, including mesenchymal cells, smooth muscle cells and endothelial is believed to play an important role in the pathophysiology of post prostatectomy erectile dysfunction.

Bone marrow mononucleated cells (BMMNC) contain different cell types that may replace the damaged penile cells after radical prostatectomy. These are mainly: mesenchymal stem cells, endothelial progenitor cells and hematopoietic stem cell. Intracavernous injection of BMMNC may therefore find application in the treatment of post prostatectomy erectile dysfunction.

The aims of this phase I-II study is to test the safety of autologous intracavernous BMMNC injection and to evaluate benefit for the patient concerning recovery of natural erection. Patients with penile vascular abnormality (echo-doppler) and localized prostate cancer (considered as cured by radical prostatectomy) will be included in this study.

Four different doses of BMMNC will be tested.

ReferenceCitation: Yiou R, Hamidou L, Birebent B, Bitari D, Le Corvoisier P, Contremoulins I, Rodriguez AM, Augustin D, Roudot-Thoraval F, de la Taille A, Rouard H. Intracavernous Injections of Bone Marrow Mononucleated Cells for Postradical Prostatectomy Erectile Dysfunction: Final Results of the INSTIN Clinical Trial. Eur Urol Focus. 2017 Dec;3(6):643-645. doi: 10.1016/j.euf.2017.06.009. Epub 2017 Jun 24.

family: Yiou

full_name: René Yiou

given: René

family: Hamidou

full_name: Leila Hamidou

given: Leila

family: Birebent

full_name: Brigitte Birebent

given: Brigitte

family: Bitari

full_name: Dalila Bitari

given: Dalila

family: Le Corvoisier

full_name: Philippe Le Corvoisier

given: Philippe

family: Contremoulins

full_name: Isabelle Contremoulins

given: Isabelle

family: Rodriguez

full_name: Anne-Marie Rodriguez

given: Anne-Marie

family: Augustin

full_name: Déborah Augustin

given: Déborah

family: Roudot-Thoraval

full_name: Françoise Roudot-Thoraval

given: Françoise

family: de la Taille

full_name: Alexandre de la Taille

given: Alexandre

family: Rouard

full_name: Hélène Rouard

given: Hélène

journal_name: European Urology Focus

ReferenceCitation: Khera M, Albersen M, Mulhall JP. Mesenchymal stem cell therapy for the treatment of erectile dysfunction. J Sex Med. 2015 May;12(5):1105-6. doi: 10.1111/jsm.12871.

family: Khera

full_name: Mohit Khera

given: Mohit

family: Albersen

full_name: Maarten Albersen

given: Maarten

family: Mulhall

full_name: John P. Mulhall

given: John P.

journal_name: The Journal of Sexual Medicine

title: Mesenchymal Stem Cell Therapy for the Treatment of Erectile Dysfunction

location_facility: CHU Henri Mondor-Albert Chenevier-Centre Intercommunal de Créteil


title: High Field MR Imaging (7T and 3T) of the Brainstem, the Deep Nuclei and Their Connections in the Parkinsonian Syndromes. Applications to Prognosis, Pathophysiology and Improvement of Therapeutic Strategies

acronym: Nucleipark

summary:
To date except for the larger striato-pallidal complex, there are no reliable imaging markers of small deep nuclei. Major improvement of the spatial resolution resulting from the use of ultra-high field MRI systems offers new perspectives of imaging of these deep structures.

We will use the new contrast mechanisms available in data acquired with ultra-high field MR systems (7T) as well as the most recent high angular diffusion imaging techniques in order to characterize the cytoarchitectonics of the deep brain structures and brainstem lesions in parkinsonian syndromes (with special interest in substantia nigra (SN) pathology and nigro-striatal fiber pathways; subthalamic nucleus (STN), red nucleus (RN), oculomotor structures (involved in PSP); pedonculo-pontine nucleus (involved in gait and posture control disorders) and the locus sub-coeruleus area (implicated in sleep disorders) The optimized MR sequences at 7T will be adapted and validated at 3T (on a more clinically oriented MRI approach).

The clinical goal of the project (via the characterization of deep brain structures) is the detection of new neuroimaging markers of neuronal lesions in PD. These biomarkers will be used to create a diagnostic tool at early stage of the disease that could be correlated to clinical signs such as gait disorders and help to identify predictive factors. In addition, this could contribute to establish an adequate therapeutic strategy (as for example with deep brain stimulation).


title: Effect of a Receptor Antagonist of Endothelin 1 (Sitaxsentan, Thelin) on Bronchial Remodeling in Severe Asthma With Fixed Bronchial Obstruction

acronym: Sitax

summary:
Introduction. Despite adequate steroid therapy, a subpopulation of approximately 10% of asthmatics develops severe persistent airflow obstruction. It is now widely agreed that the latter is the consequence of a remodeling process of the airways, characterized by an increase in airway smooth muscle mass, mucus gland hypertrophy, increased thickness of the subepithelial basement membrane, extracellular matrix protein deposition, angiogenesis, fibroblast and myofibroblast accumulation. These phenomena are responsible for airway wall thickening and for decreased airway caliber leading to persistent airflow obstruction.

Endothelin-1 (ET-1) is a small peptide, synthesized in the lung by airway epithelial and smooth muscle cells, as well as inflammatory cells. ET-1 induces bronchoconstriction, mediates eosinophils recruitment during allergic inflammation and contributes to airway remodeling by inducing fibroblasts and smooth muscle cells differentiation and proliferation. In a recent work from Inserm Unit 700, it has been shown that ET-1 was overexpressed in epithelial cells from severe asthmatic patients as compared to patients with less severe disease, and that ET-1 expression was strongly correlated with airway obstruction (measured by FEV1) and on bronchial biopsies with airway smooth muscle areas. In another study, we have shown that a polymorphism of the receptor for ET-1 was strongly associated with the degree of airway obstruction in a population of asthmatic patients. All these data suggest that inhibition of the ET-1 pathway could be a potential therapeutic option in patients with steroids refractory asthma and irreversible airway obstruction. Bosentan, a specific inhibitor of ET-1 receptors which is actually used in patients with pulmonary hypertension, improves survival and inhibits vascular remodeling.

Aim and strategy. To study the impact on airway remodeling and clinical status of an antagonist of the endothelin receptors (Sitaxentan 100mg/day) over a 12-month period, in a prospective randomised placebo-controlled trial involving two parallel groups of 25 severe asthmatic patients with irreversible airflow obstruction (FEV1≤ 70% of predicted) . Various hallmarks of airway remodeling will be analyzed on bronchial biopsy specimens by immunohistochemistry and morphometry. These findings will be correlated with the results of pulmonary function tests. Twenty-five patients will be included in each group. Remodeling will be measured on bronchial biopsies performed during fiberoptic bronchoscopy at inclusion and after one year, by assessing smooth muscle area, submucosal fibroblasts count and basement membrane thickness. Every 3 months, bronchial obstruction (FEV1), clinical status, asthma exacerbations, steroids use, need for emergency care, asthma symptoms and quality of life will be assessed. Evaluation of airway inflammation will be assessed every 3 months by exhaled NO and induced sputum cytology.

This proof of concept study will validate ET-1 as a new molecular target for treating airway remodeling in patients with severe asthma.

location_facility: Clinical Investigation center 07, Hopital Bichat


title: Prospective Study of Individuals at Risk for Spinocerebellar Ataxia Type 1, Type 2, Type 3, Type 6 and Type 7 (SCA1, SCA2, SCA3, SCA6, SCA7)

acronym: RISCA

summary:
The spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of autosomal dominantly inherited progressive ataxia disorders. It is estimated that there are 30,000 individuals in the European Community that directly descend from individuals affected by a SCA disorder and thus carry a 50% risk of having inherited an SCA mutation. These at risk individuals provide a unique research opportunity to prospectively study the presymptomatic phase of SCA disorders and to identify the earliest and most sensitive clinical signs and biological markers that herald the onset of the illness. This information is of critical importance for the development of future therapeutic interventions aimed at postponing the clinical onset of ataxia.

We therefore propose to perform a prospective observational study of individuals at risk for the most common SCA disorders, SCA1, SCA2, SCA3 and SCA6 (RISCA). It is our aim to answer the following questions: (1) What is the incidence of disease manifestation in mutation carriers? (2) Which clinical signs precede the onset of manifest ataxia in SCA1, SCA2, SCA3 and SCA6? (3) What are the prevalence and incidence of preceding signs? (4) Are the prevalence and incidence of preceding signs affected by genotype, gender, age, estimated time until disease manifestation and repeat length? (5) Does the presence of certain preceding signs predict the manifestation of ataxia ? (6) Are there MRI alterations that precede the onset of ataxia? It is planned to enroll 480 study participants and to follow them at regular intervals over six years. At each visit, study participants are asked in a structured interview for a number of predefined clinical signs that potentially precede the onset of ataxia. In addition, the following self-assessment scales will be applied: Pittsburgh Sleep Quality Index (PSQI), Diagnostic Criteria for Restless Legs Syndrome, Patient´s Health Questionnaire (PHQ-9). All study participants will undergo a physical examination including the Scale for the Assessment and Rating of Ataxia (SARA). Study participants will further perform the SCA Functional Composite (SCA-FC) which is a comprehensive measure of functional capacity based on results in quantitative tests related to gait (8m timed walk), speech (PATA rate) and hand function (9 hole pegboard). In a subset of study participants, we will record eye movements and obtain volumetric MRIs. The study will also be used to collect and store blood and urine samples for proteomic and gene expression studies.

RISCA is conducted by the Ataxia Study Group (ASG). It relies on the network structure created by the EUROSCA project.

ReferenceCitation: Jacobi H, du Montcel ST, Romanzetti S, Harmuth F, Mariotti C, Nanetti L, Rakowicz M, Makowicz G, Durr A, Monin ML, Filla A, Roca A, Schöls L, Hengel H, Infante J, Kang JS, Timmann D, Casali C, Masciullo M, Baliko L, Melegh B, Nachbauer W, Bürk-Gergs K, Schulz JB, Riess O, Reetz K, Klockgether T. Conversion of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 to manifest ataxia (RISCA): a longitudinal cohort study. Lancet Neurol. 2020 Sep;19(9):738-747. doi: 10.1016/S1474-4422(20)30235-0.

family: Jacobi

full_name: Heike Jacobi

given: Heike

family: du Montcel

full_name: Sophie Tezenas du Montcel

given: Sophie Tezenas

family: Romanzetti

full_name: Sandro Romanzetti

given: Sandro

family: Harmuth

full_name: Florian Harmuth

given: Florian

family: Mariotti

full_name: Caterina Mariotti

given: Caterina

family: Nanetti

full_name: Lorenzo Nanetti

given: Lorenzo

family: Rakowicz

full_name: Maria Rakowicz

given: Maria

family: Makowicz

full_name: Grzegorz Makowicz

given: Grzegorz

family: Durr

full_name: Alexandra Durr

given: Alexandra

family: Monin

full_name: Marie-Lorraine Monin

given: Marie-Lorraine

family: Filla

full_name: Alessandro Filla

given: Alessandro

family: Roca

full_name: Alessandro Roca

family: Schöls

full_name: Ludger Schöls

given: Ludger

family: Hengel

full_name: Holger Hengel

given: Holger

family: Infante

full_name: Jon Infante

given: Jon

family: Kang

full_name: Jun-Suk Kang

given: Jun-Suk

family: Timmann

full_name: Dagmar Timmann

given: Dagmar

family: Casali

full_name: Carlo Casali

given: Carlo

family: Masciullo

full_name: Marcella Masciullo

given: Marcella

family: Baliko

full_name: Laszlo Baliko

given: Laszlo

family: Melegh

full_name: Bela Melegh

given: Bela

family: Nachbauer

full_name: Wolfgang Nachbauer

given: Wolfgang

family: Bürk-Gergs

full_name: Katrin Bürk-Gergs

given: Katrin

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: CERN European Organization for Nuclear Research - Zenodo

ReferenceCitation: Tezenas du Montcel S, Durr A, Rakowicz M, Nanetti L, Charles P, Sulek A, Mariotti C, Rola R, Schols L, Bauer P, Dufaure-Garé I, Jacobi H, Forlani S, Schmitz-Hübsch T, Filla A, Timmann D, van de Warrenburg BP, Marelli C, Kang JS, Giunti P, Cook A, Baliko L, Melegh B, Boesch S, Szymanski S, Berciano J, Infante J, Buerk K, Masciullo M, Di Fabio R, Depondt C, Ratka S, Stevanin G, Klockgether T, Brice A, Golmard JL. Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6. J Med Genet. 2014 Jul;51(7):479-86. doi: 10.1136/jmedgenet-2013-102200. Epub 2014 Apr 29. Erratum in: J Med Genet. 2014 Sep;51(9):613. Bela, Melegh [corrected to Melegh, Béla].

repository_institution: University of Oxford - Oxford Academic Notes & Queries

repository_institution: Université Libre de Bruxelles - Dépôt institutionnel de l'Université libre de Bruxelles

evidence: oa repository (via OAI-PMH title and last author match)

repository_institution: Goethe University Frankfurt - Publication Server of Goethe University Frankfurt am Main

repository_institution: University College London - UCL Discovery

repository_institution: Library of the Hungarian Academy of Sciences - Repository of the Academy's Library

ReferenceCitation: Jacobi H, Reetz K, du Montcel ST, Bauer P, Mariotti C, Nanetti L, Rakowicz M, Sulek A, Durr A, Charles P, Filla A, Antenora A, Schöls L, Schicks J, Infante J, Kang JS, Timmann D, Di Fabio R, Masciullo M, Baliko L, Melegh B, Boesch S, Bürk K, Peltz A, Schulz JB, Dufaure-Garé I, Klockgether T. Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data. Lancet Neurol. 2013 Jul;12(7):650-8. doi: 10.1016/S1474-4422(13)70104-2. Epub 2013 May 22. Erratum in: Lancet Neurol. 2013 Jul;12(7):630.


title: Identification Of Blood Markers For Asymptomatic Ventricular Dysfunction

acronym: IBLOMAVED

summary: The diagnosis of asymptomatic left ventricular dysfunction is difficult in general practice since it requires transthoracic cardiac echocardiography that is generally performed in specialized services. Although blood BNP levels monitoring can be of some help in heart failure diagnosis is is mostly a late biomarker that is secreted upon heart stretch and has many limitations. Therefore the aim of this study is to identify new specific blood biomarkers that would help for asymptomatic left ventricular dysfunction diagnosis in large populations with cardiovascular risk.

ReferenceCitation: Koukoui F, Desmoulin F, Galinier M, Barutaut M, Caubère C, Evaristi MF, Murat G, De Boer R, Berry M, Smih F, Rouet P. The prognostic value of plasma galectin-3 in chronic heart failure patients is maintained when treated with mineralocorticoid receptor antagonists. PLoS One. 2015 Mar 18;10(3):e0119160. doi: 10.1371/journal.pone.0119160. eCollection 2015.

family: Koukoui

full_name: François Koukoui

given: François

family: Desmoulin

full_name: Franck Desmoulin

given: Franck

family: Galinier

full_name: Michel Galinier

given: Michel

family: Barutaut

full_name: Manon Barutaut

given: Manon

family: Caubère

full_name: Celine Caubère

given: Celine

family: Evaristi

full_name: Maria Francesca Evaristi

given: Maria Francesca

family: Murat

full_name: Gurbuz Murat

given: Gurbuz

family: De Boer

full_name: Rudolf De Boer

given: Rudolf

family: Berry

full_name: Matthieu Berry

given: Matthieu

family: Smih

full_name: Fatima Smih

given: Fatima

family: Rouet

full_name: Philippe Rouet

given: Philippe

journal_name: PLOS ONE

oa_colors: green gold

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

repository_institution: DANS - Data Archiving and Networked Services - NARCIS - National Academic Research and Collaborations Information System

evidence: oa repository (semantic scholar lookup)

publisher: Public Library of Science (PLoS)

publisher_dissemination: Public Library of Science

publisher_group: Public Library of Science

publisher_normalized: Public Library of Science

title: The Prognostic Value of Plasma Galectin-3 in Chronic Heart Failure Patients Is Maintained when Treated with Mineralocorticoid Receptor Antagonists

location_facility: Hospital from Toulouse Rangueil, Pr Galinier department (Cardiology A)


title: Specific Vaccine Therapy in Chronic Hepatitis B Using a Naked DNA: Phase I Study Using a GMO

summary: The purpose of this study was to investigate whether HBV-DNA vaccination is safe and could restore immune responses in patients with chronic hepatitis B non responder to available therapies.

ReferenceCitation: Mancini-Bourgine M, Fontaine H, Scott-Algara D, Pol S, Bréchot C, Michel ML. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology. 2004 Oct;40(4):874-82.

ReferenceCitation: Mancini-Bourgine M, Fontaine H, Bréchot C, Pol S, Michel ML. Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine. 2006 May 22;24(21):4482-9. Epub 2005 Aug 18.

ReferenceCitation: Scott-Algara D, Mancini-Bourgine M, Fontaine H, Pol S, Michel ML. Changes to the natural killer cell repertoire after therapeutic hepatitis B DNA vaccination. PLoS One. 2010 Jan 18;5(1):e8761. doi: 10.1371/journal.pone.0008761.

family: Scott-Algara

full_name: Daniel Scott-Algara

given: Daniel

family: Mancini-Bourgine

full_name: Maryline Mancini-Bourgine

given: Maryline

family: Fontaine

full_name: Hélène Fontaine

given: Hélène

family: Pol

full_name: Stanislas Pol

given: Stanislas

family: Michel

full_name: Marie-Louise Michel

given: Marie-Louise

bso_classification: Biology (fond.)

journal_name: PLoS ONE

repository_institution: The Pennsylvania State University - CiteSeer X

repository_normalized: CiteSeerX

repositories:
CiteSeerX
HAL
PubMed Central
pdfs.semanticscholar.org

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

title: Changes to the Natural Killer Cell Repertoire after Therapeutic Hepatitis B DNA Vaccination

location_facility: Service d'Hepatologie, Hopital Necker Enfants Malades


title: Randomized Study on Removable PGE2 Vaginal Insert Versus PGE2 Intravaginal Gel for Cervical Priming and Labour Induction in Term Pregnancy

summary: The aim of this study is to compare two different preparation

ReferenceCitation: Lyrenäs S, Clason I, Ulmsten U. In vivo controlled release of PGE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour. BJOG. 2001 Feb;108(2):169-78.

ReferenceCitation: Strobelt N, Meregalli V, Ratti M, Mariani S, Zani G, Morana S. Randomized study on removable PGE2 vaginal insert versus PGE2 cervical gel for cervical priming and labor induction in low-Bishop-score pregnancy. Acta Obstet Gynecol Scand. 2006;85(3):302-5.

ReferenceCitation: El-Shawarby SA, Connell RJ. Induction of labour at term with vaginal prostaglandins preparations: a randomised controlled trial of Prostin vs Propess. J Obstet Gynaecol. 2006 Oct;26(7):627-30.

location_facility: Olympe de Gouges Women Health Centre, Bretonneau University Hospital


title: The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.

summary: It has been suggested that a low dietary intake of antioxidant vitamins and minerals increases the incidence rate of cardiovascular disease and cancer. To date, however, the published results of randomized, placebo-controlled trials of supplements containing antioxidant nutrients have not provided clear evidence of a beneficial effect. We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population.

ReferenceCitation: Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briançon S. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004 Nov 22;164(21):2335-42. Erratum in: Arch Intern Med. 2005 Feb 14;165(3):286.

ReferenceCitation: Andreeva VA, Péneau S, Julia C, Shivappa N, Hébert JR, Wirth MD, Touvier M, Hercberg S, Galan P, Kesse-Guyot E. The inflammatory potential of the diet is prospectively associated with subjective hearing loss. Eur J Nutr. 2021 Oct;60(7):3669-3678. doi: 10.1007/s00394-021-02531-1. Epub 2021 Mar 18.

family: Andreeva

full_name: Valentina A. Andreeva

given: Valentina A.

family: Péneau

full_name: Sandrine Péneau

given: Sandrine

family: Julia

full_name: Chantal Julia

given: Chantal

family: Shivappa

full_name: Nitin Shivappa

given: Nitin

family: Hébert

full_name: James R. Hébert

given: James R.

family: Wirth

full_name: Michael D. Wirth

given: Michael D.

family: Touvier

full_name: Mathilde Touvier

given: Mathilde

family: Hercberg

full_name: Serge Hercberg

given: Serge

family: Galan

full_name: Pilar Galan

given: Pilar

family: Kesse-Guyot

full_name: Emmanuelle Kesse-Guyot

given: Emmanuelle

journal_name: European Journal of Nutrition

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer

title: The inflammatory potential of the diet is prospectively associated with subjective hearing loss

ReferenceCitation: Lécuyer L, Dalle C, Micheau P, Pétéra M, Centeno D, Lyan B, Lagree M, Galan P, Hercberg S, Rossary A, Demidem A, Vasson MP, Partula V, Deschasaux M, Srour B, Latino-Martel P, Druesne-Pecollo N, Kesse-Guyot E, Durand S, Pujos-Guillot E, Manach C, Touvier M. Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort. Eur J Nutr. 2020 Dec;59(8):3425-3439. doi: 10.1007/s00394-020-02177-5. Epub 2020 Jan 11.

family: Lécuyer

full_name: Lucie Lécuyer

given: Lucie

family: Dalle

full_name: Céline Dalle

given: Céline

family: Micheau

full_name: Pierre Micheau

given: Pierre

family: Pétéra

full_name: Mélanie Pétéra

given: Mélanie

family: Centeno

full_name: Delphine Centeno

given: Delphine

family: Lyan

full_name: Bernard Lyan

given: Bernard

family: Lagree

full_name: Marie Lagree

given: Marie

family: Rossary

full_name: Adrien Rossary

given: Adrien

family: Demidem

full_name: Aicha Demidem

given: Aicha

title: Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort

ReferenceCitation: Lécuyer L, Dalle C, Lyan B, Demidem A, Rossary A, Vasson MP, Petera M, Lagree M, Ferreira T, Centeno D, Galan P, Hercberg S, Deschasaux M, Partula V, Srour B, Latino-Martel P, Kesse-Guyot E, Druesne-Pecollo N, Durand S, Pujos-Guillot E, Touvier M. Plasma Metabolomic Signatures Associated with Long-term Breast Cancer Risk in the SU.VI.MAX Prospective Cohort. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1300-1307. doi: 10.1158/1055-9965.EPI-19-0154. Epub 2019 Jun 4.

journal_name: Cancer Epidemiology Biomarkers & Prevention

publisher: American Association for Cancer Research (AACR)

publisher_dissemination: American Association for Cancer Research

publisher_group: American Association for Cancer Research

publisher_normalized: American Association for Cancer Research

title: Plasma Metabolomic Signatures Associated with Long-term Breast Cancer Risk in the SU.VI.MAX Prospective Cohort

ReferenceCitation: Assmann KE, Adjibade M, Hercberg S, Galan P, Kesse-Guyot E. Unsaturated Fatty Acid Intakes During Midlife Are Positively Associated with Later Cognitive Function in Older Adults with Modulating Effects of Antioxidant Supplementation. J Nutr. 2018 Dec 1;148(12):1938-1945. doi: 10.1093/jn/nxy206.

name: Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Statistiques Sorbonne Paris Cité, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, Bobigny, France

name: Département de Santé Publique, Hôpital Avicenne, Bobigny, France

ReferenceCitation: Wiernik E, Lemogne C, Fezeu L, Arnault N, Hercberg S, Kesse-Guyot E, Galan P. Association Between Alexithymia and Risk of Incident Cardiovascular Diseases in the SUpplémentation en VItamines et Minéraux AntioXydants (SU.VI.MAX) Cohort. Psychosom Med. 2018 Jun;80(5):460-467. doi: 10.1097/PSY.0000000000000592.

ReferenceCitation: Assmann KE, Adjibade M, Shivappa N, Hébert JR, Wirth MD, Touvier M, Akbaraly T, Hercberg S, Galan P, Julia C, Kesse-Guyot E. The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults. J Nutr. 2018 Mar 1;148(3):437-444. doi: 10.1093/jn/nxx061.

name: Paris 13 University, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory of Arts and Crafts (CNAM), Sorbonne Paris Cité COMUE, Bobigny, France

name: Cancer Prevention and Control Program, and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC

name: Connecting Health Innovations LLC, Columbia, SC

name: MMDN, Univ. Montpellier, EPHE, INSERM, U1198, Montpellier, France

name: University College London, Department of Epidemiology and Public Health, London, United Kingdom

name: Department of Public Health, Hôpital Avicenne (AP-HP), Bobigny, France

title: The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults

ReferenceCitation: Ruhunuhewa I, Adjibade M, Andreeva VA, Galan P, Hercberg S, Assmann KE, Kesse-Guyot E. Prospective association between body mass index at midlife and healthy aging among French adults. Obesity (Silver Spring). 2017 Jul;25(7):1254-1262. doi: 10.1002/oby.21853. Epub 2017 May 11.

name: Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Statistiques Sorbonne Paris Cité, INSERM (U1153), INRA (U1125), CNAM, COMUE Sorbonne Paris Cité; Bobigny France

name: Département de Santé Publique; Hôpital Avicenne; Bobigny France

title: Prospective association between body mass index at midlife and healthy aging among French adults

ReferenceCitation: Adjibade M, Andreeva VA, Lemogne C, Touvier M, Shivappa N, Hébert JR, Wirth MD, Hercberg S, Galan P, Julia C, Assmann KE, Kesse-Guyot E. The Inflammatory Potential of the Diet Is Associated with Depressive Symptoms in Different Subgroups of the General Population. J Nutr. 2017 May;147(5):879-887. doi: 10.3945/jn.116.245167. Epub 2017 Mar 29.

name: Faculty of Medicine, Paris Descartes University, Sorbonne Paris Cité, Paris, France

name: Adult and Elderly Psychiatry Department, AP-HP, Paris Ouest University Hospitals, Paris, France

name: U894 National Institute of Health and Medical Research, Psychiatry and Neurosciences Center, Paris, France

name: Cancer Prevention and Control Program, University of South Carolina, Columbia, SC

name: Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC

name: Public Health Department, Avicenne Hospital, Bobigny, France

title: The Inflammatory Potential of the Diet Is Associated with Depressive Symptoms in Different Subgroups of the General Population

ReferenceCitation: Walker V, Perret-Guillaume C, Kesse-Guyot E, Agrinier N, Hercberg S, Galan P, Assmann KE, Briançon S, Rotonda C. Effect of Multimorbidity on Health-Related Quality of Life in Adults Aged 55 Years or Older: Results from the SU.VI.MAX 2 Cohort. PLoS One. 2016 Dec 29;11(12):e0169282. doi: 10.1371/journal.pone.0169282. eCollection 2016.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - ENSM-SE

repositories:
HAL
PubMed Central
pdfs.semanticscholar.org

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - ENSM-SE

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

title: Effect of Multimorbidity on Health-Related Quality of Life in Adults Aged 55 Years or Older: Results from the SU.VI.MAX 2 Cohort

ReferenceCitation: Kesse-Guyot E, Assmann KE, Andreeva VA, Touvier M, Neufcourt L, Shivappa N, Hébert JR, Wirth MD, Hercberg S, Galan P, Julia C. Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr. 2017 Jun;56(4):1647-1655. doi: 10.1007/s00394-016-1211-3. Epub 2016 Apr 7.

title: Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study

ReferenceCitation: Adriouch S, Julia C, Kesse-Guyot E, Méjean C, Ducrot P, Péneau S, Donnenfeld M, Deschasaux M, Menai M, Hercberg S, Touvier M, Fezeu LK. Prospective association between a dietary quality index based on a nutrient profiling system and cardiovascular disease risk. Eur J Prev Cardiol. 2016 Oct;23(15):1669-76. doi: 10.1177/2047487316640659. Epub 2016 Mar 21.

name: Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, France

name: Département de Santé Publique, Hôpital Avicenne, France

journal_name: European Journal of Preventive Cardiology

title: Prospective association between a dietary quality index based on a nutrient profiling system and cardiovascular disease risk

ReferenceCitation: Graffouillère L, Deschasaux M, Mariotti F, Neufcourt L, Shivappa N, Hébert JR, Wirth MD, Latino-Martel P, Hercberg S, Galan P, Julia C, Kesse-Guyot E, Touvier M. The Dietary Inflammatory Index Is Associated with Prostate Cancer Risk in French Middle-Aged Adults in a Prospective Study. J Nutr. 2016 Apr 1;146(4):785-791. Epub 2016 Mar 9.

ReferenceCitation: Graffouillère L, Deschasaux M, Mariotti F, Neufcourt L, Shivappa N, Hébert JR, Wirth MD, Latino-Martel P, Hercberg S, Galan P, Julia C, Kesse-Guyot E, Touvier M. Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial. Am J Clin Nutr. 2016 Mar;103(3):878-85. doi: 10.3945/ajcn.115.126243. Epub 2016 Feb 10.

journal_name: The American Journal of Clinical Nutrition

ReferenceCitation: Deschasaux M, Souberbielle JC, Latino-Martel P, Sutton A, Charnaux N, Druesne-Pecollo N, Galan P, Hercberg S, Le Clerc S, Kesse-Guyot E, Ezzedine K, Touvier M. Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk. J Nutr. 2016 Mar;146(3):576-85. doi: 10.3945/jn.115.221481. Epub 2016 Jan 27.

name: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France

name: Physiology Department, Necker Hospital, Inserm U845, Paris, France

name: Biochemistry Department, Jean Verdier Hospital, Inserm U698, Paris 13 University, Bondy, France

name: Conservatoire National des Arts et Métiers (CNAM), Genomics, Bioinformatics and Applications Team (EA4627), Paris, France

name: Dermatology Department, Saint André Hospital, Bordeaux, France

title: Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk

ReferenceCitation: Kesse-Guyot E, Assmann KE, Andreeva VA, Ferry M, Hercberg S, Galan P; SU.VI.MAX 2 Research Group. Consumption of Dairy Products and Cognitive Functioning: Findings from the SU.VI.MAX 2 Study. J Nutr Health Aging. 2016 Feb;20(2):128-37. doi: 10.1007/s12603-015-0593-x.

journal_name: The journal of nutrition, health & aging

title: Consumption of dairy products and cognitive functioning: Findings from the SU.VI.MAX 2 study

ReferenceCitation: Deschasaux M, Souberbielle JC, Latino-Martel P, Sutton A, Charnaux N, Druesne-Pecollo N, Galan P, Hercberg S, Le Clerc S, Kesse-Guyot E, Ezzedine K, Touvier M. Prospective associations between vitamin D status, vitamin D-related gene polymorphisms, and risk of tobacco-related cancers. Am J Clin Nutr. 2015 Nov;102(5):1207-15. doi: 10.3945/ajcn.115.110510. Epub 2015 Oct 7.

title: Prospective associations between vitamin D status, vitamin D–related gene polymorphisms, and risk of tobacco-related cancers

ReferenceCitation: Kesse-Guyot E, Lassale C, Assmann KE, Andreeva VA, Julia C, Blacher J, Fezeu L, Hercberg S, Galan P. Are different vascular risk scores calculated at midlife uniformly associated with subsequent poor cognitive performance? Atherosclerosis. 2015 Nov;243(1):286-92. doi: 10.1016/j.atherosclerosis.2015.09.023. Epub 2015 Sep 21.

repositories_institution: University College London - UCL Discovery

title: Are different vascular risk scores calculated at midlife uniformly associated with subsequent poor cognitive performance?

ReferenceCitation: Donnenfeld M, Deschasaux M, Latino-Martel P, Diallo A, Galan P, Hercberg S, Ezzedine K, Touvier M. Prospective association between dietary folate intake and skin cancer risk: results from the Supplémentation en Vitamines et Minéraux Antioxydants cohort. Am J Clin Nutr. 2015 Aug;102(2):471-8. doi: 10.3945/ajcn.115.109041. Epub 2015 Jul 8.

title: Prospective association between dietary folate intake and skin cancer risk: results from the Supplémentation en Vitamines et Minéraux Antioxydants cohort1

ReferenceCitation: Chhim AS, Fassier P, Latino-Martel P, Druesne-Pecollo N, Zelek L, Duverger L, Hercberg S, Galan P, Deschasaux M, Touvier M. Prospective association between alcohol intake and hormone-dependent cancer risk: modulation by dietary fiber intake. Am J Clin Nutr. 2015 Jul;102(1):182-9. doi: 10.3945/ajcn.114.098418. Epub 2015 May 20.

name: Sorbonne Paris Cité Epidemiology and Biostatistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7, and 5 Universities, Bobigny, France;

name: Public Health Departments, Avicenne Hospital, Bobigny, France

title: Prospective association between alcohol intake and hormone-dependent cancer risk: modulation by dietary fiber intake

ReferenceCitation: Kesse-Guyot E, Andreeva VA, Touvier M, Jeandel C, Ferry M, Hercberg S, Galan P; SU.VI.MAX 2 Research Group. Overall and abdominal adiposity in midlife and subsequent cognitive function. J Nutr Health Aging. 2015 Feb;19(2):183-9. doi: 10.1007/s12603-014-0508-2.

title: Overall and abdominal adiposity in midlife and subsequent cognitive function

ReferenceCitation: Deschasaux M, Pouchieu C, His M, Hercberg S, Latino-Martel P, Touvier M. Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk. J Nutr. 2014 Apr;144(4):504-10. doi: 10.3945/jn.113.189670. Epub 2014 Feb 19.

name: Sorbonne Paris Cité Research Center, Nutritional Epidemiology Research Team, U1153 National Institute of Health and Medical Research, U1125 National Institute for Agricultural Research, National Conservatory of Arts and Crafts, Paris 13 University, Bobigny, France

title: Dietary Total and Insoluble Fiber Intakes Are Inversely Associated with Prostate Cancer Risk

ReferenceCitation: Touvier M, Deschasaux M, Montourcy M, Sutton A, Charnaux N, Kesse-Guyot E, Fezeu LK, Latino-Martel P, Druesne-Pecollo N, Malvy D, Galan P, Hercberg S, Ezzedine K, Souberbielle JC. Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values. J Clin Endocrinol Metab. 2014 Apr;99(4):1196-203. doi: 10.1210/jc.2013-3349. Epub 2014 Feb 14.

name: Sorbonne Paris Cité Research Center (M.T., M.D., M.M., E.K.-G., L.K.F., P.L.-M., N.D.-P., P.G., S.H., K.E.), F-93017 Bobigny, France;

name: Nutritional Epidemiology Research Team, INSERM Unité 557, Institut National de la Recherche Agronomique Unité 1125, Conservatoire National des Arts et Métiers, and INSERM Unité 698 (A.S., N.C.), Paris 13 University, F-93017 Bobigny, France;

name: Department Biochemistry (A.S., N.C.), Jean Verdier Hospital, F-93143 Bondy, France;

name: Department of Dermatology (D.M., K.E.), St André Hospital, F-33000 Bordeaux, France;

name: Department of Public Health (S.H.), Avicenne Hospital, F-93009 Bobigny, France;

name: Department of Physiology (J.-C.S.), Necker Hospital (Assistance Publique-Hôpitaux de Paris), and INSERM Unité 845, F-75270 Paris, France

journal_name: The Journal of Clinical Endocrinology & Metabolism

title: Interpretation of Plasma PTH Concentrations According to 25OHD Status, Gender, Age, Weight Status, and Calcium Intake: Importance of the Reference Values

ReferenceCitation: Andreeva VA, Galan P, Arnaud J, Julia C, Hercberg S, Kesse-Guyot E. Midlife iron status is inversely associated with subsequent cognitive performance, particularly in perimenopausal women. J Nutr. 2013 Dec;143(12):1974-81. doi: 10.3945/jn.113.177089. Epub 2013 Oct 2.

name: Nutritional Epidemiology Research Unit, Sorbonne-Paris-Cité, UMR University of Paris XIII, INSERM U557/INRA U1125/CNAM, Bobigny, France

name: CHU Institut de Biologie et Pathologie, Unité de Biochimie Hormonale et Nutritionnelle, INSERM U1055, Grenoble, France

name: Department of Public Health, Avicenne Hospital, Bobigny, France

title: Midlife Iron Status Is Inversely Associated with Subsequent Cognitive Performance, Particularly in Perimenopausal Women

ReferenceCitation: Julia C, Touvier M, Meunier N, Papet I, Galan P, Hercberg S, Kesse-Guyot E. Intakes of PUFAs were inversely associated with plasma C-reactive protein 12 years later in a middle-aged population with vitamin E intake as an effect modifier. J Nutr. 2013 Nov;143(11):1760-6. doi: 10.3945/jn.113.180943. Epub 2013 Sep 11.

name: Inserm (National Institute of Health and Medical Research), U557 Nutritional Epidemiology Unit, Bobigny, France

name: CNAM, Nutritional Epidemiology Unit, Bobigny, France

name: Université Paris 13, Sorbonne Paris Cité, Nutritional Epidemiology Unit, Bobigny, France

name: CHU Clermont-Ferrand, Unité d'Exploration en Nutrition, Clermont-Ferrand, France

name: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France

name: INRA, UNH, CRNH Auvergne, Clermont-Ferrand, France

title: Intakes of PUFAs Were Inversely Associated with Plasma C-Reactive Protein 12 Years Later in a Middle-Aged Population with Vitamin E Intake as an Effect Modifier

ReferenceCitation: Kesse-Guyot E, Andreeva VA, Jeandel C, Ferry M, Touvier M, Hercberg S, Galan P. Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort. PLoS One. 2012;7(12):e52311. doi: 10.1371/journal.pone.0052311. Epub 2012 Dec 19.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

title: Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort

ReferenceCitation: Kesse-Guyot E, Andreeva VA, Lassale C, Ferry M, Jeandel C, Hercberg S, Galan P; SU.VI.MAX 2 Research Group. Mediterranean diet and cognitive function: a French study. Am J Clin Nutr. 2013 Feb;97(2):369-76. doi: 10.3945/ajcn.112.047993. Epub 2013 Jan 2.

name: From the Université Paris 13, Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), INSERM (U557), Institut National de la Recherche Agronomique (U1125), and Conservatoire National des Arts et Métiers, Bobigny, France (EK-G, VAA, CL, MF, SH, and PG); the Département de Santé Publique, Hôpital Avicenne, Bobigny, France (SH); and the Centre de Gérontologie, Clinique Antonin Balmes, CH

title: Mediterranean diet and cognitive function: a French study

ReferenceCitation: Kesse-Guyot E, Charreire H, Andreeva VA, Touvier M, Hercberg S, Galan P, Oppert JM. Cross-sectional and longitudinal associations of different sedentary behaviors with cognitive performance in older adults. PLoS One. 2012;7(10):e47831. doi: 10.1371/journal.pone.0047831. Epub 2012 Oct 17.

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Jean Moulin Lyon 3

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Jean Moulin Lyon 3

title: Cross-Sectional and Longitudinal Associations of Different Sedentary Behaviors with Cognitive Performance in Older Adults

ReferenceCitation: Kesse-Guyot E, Ahluwalia N, Lassale C, Hercberg S, Fezeu L, Lairon D. Adherence to Mediterranean diet reduces the risk of metabolic syndrome: a 6-year prospective study. Nutr Metab Cardiovasc Dis. 2013 Jul;23(7):677-83. doi: 10.1016/j.numecd.2012.02.005. Epub 2012 May 25.

journal_name: Nutrition, Metabolism and Cardiovascular Diseases

title: Adherence to Mediterranean diet reduces the risk of metabolic syndrome: A 6-year prospective study

ReferenceCitation: Touvier M, Kesse-Guyot E, Andreeva VA, Fezeu L, Charnaux N, Sutton A, Druesne-Pecollo N, Hercberg S, Galan P, Zelek L, Latino-Martel P, Czernichow S. Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study. Am J Clin Nutr. 2012 Apr;95(4):944-50. doi: 10.3945/ajcn.111.027805. Epub 2012 Feb 29.

ReferenceCitation: Briançon S, Boini S, Bertrais S, Guillemin F, Galan P, Hercberg S. Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial. Int J Epidemiol. 2011 Dec;40(6):1605-16. doi: 10.1093/ije/dyr161.

title: Long-term antioxidant supplementation has no effect on health-related quality of life: The randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial

ReferenceCitation: Péneau S, Galan P, Jeandel C, Ferry M, Andreeva V, Hercberg S, Kesse-Guyot E; SU.VI.MAX 2 Research Group. Fruit and vegetable intake and cognitive function in the SU.VI.MAX 2 prospective study. Am J Clin Nutr. 2011 Nov;94(5):1295-303. doi: 10.3945/ajcn.111.014712. Epub 2011 Sep 28.

name: From Centre de Gérontologie, Clinique Antonin Balmes, CHU Montpellier Université I, Montpellier, France (SP and CJ); Unité de Recherche en Epidémiologie Nutritionnelle, U557 INSERM/U1125 Inra/Cnam/Université Paris 13, CRNH IdF, Bobigny, France (SP, PG, CJ, MF, VA, SH, and EK-G); Unité de Surveillance et d’Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Bobigny, Fr

title: Fruit and vegetable intake and cognitive function in the SU.VI.MAX 2 prospective study

ReferenceCitation: Kesse-Guyot E, Fezeu L, Jeandel C, Ferry M, Andreeva V, Amieva H, Hercberg S, Galan P. French adults' cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial. Am J Clin Nutr. 2011 Sep;94(3):892-9. doi: 10.3945/ajcn.110.007815. Epub 2011 Jul 20.

ReferenceCitation: Pérez-Jiménez J, Fezeu L, Touvier M, Arnault N, Manach C, Hercberg S, Galan P, Scalbert A. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr. 2011 Jun;93(6):1220-8. doi: 10.3945/ajcn.110.007096. Epub 2011 Apr 13.

repositories_institution: The Pennsylvania State University - CiteSeer X

title: Dietary intake of 337 polyphenols in French adults

ReferenceCitation: Kesse-Guyot E, Amieva H, Castetbon K, Henegar A, Ferry M, Jeandel C, Hercberg S, Galan P; SU.VI.MAX 2 Research Group. Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) study. Am J Clin Nutr. 2011 Jan;93(1):200-10. doi: 10.3945/ajcn.2010.29761. Epub 2010 Nov 24.

name: From the Unité de Recherche en Epidémiologie Nutritionnelle, U557 INSERM/U1125 Inra/Cnam/Université Paris 13, CRNH IdF, Bobigny, France (EK-G, AH, MF, SH, and PG); the U897 INSERM, Université Victor Segalen Bordeaux 2, Bordeaux Cedex, France (HA and SH); the Unité de Surveillance et d’Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Bobigny, France (KC and SH); the

ReferenceCitation: Ezzedine K, Latreille J, Kesse-Guyot E, Galan P, Hercberg S, Guinot C, Malvy D. Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation. Eur J Cancer. 2010 Dec;46(18):3316-22. doi: 10.1016/j.ejca.2010.06.008. Epub 2010 Jul 6.

title: Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation

ReferenceCitation: Kesse-Guyot E, Vergnaud AC, Fezeu L, Zureik M, Blacher J, Péneau S, Hercberg S, Galan P, Czernichow S. Associations between dietary patterns and arterial stiffness, carotid artery intima-media thickness and atherosclerosis. Eur J Cardiovasc Prev Rehabil. 2010 Dec;17(6):718-24. doi: 10.1097/HJR.0b013e32833a197f.

name: UMR INSERM U557/INRA U1125/CNAM/Université Paris 13, CRNH-IdF, Bobigny, France

name: Unit Hypertension artérielle, Hôpital Hôtel-Dieu, Université Paris Descartes, Paris, France

name: Public Health Department, Avicenne Hospital and University Paris 13, Bobigny, France

journal_name: European Journal of Cardiovascular Prevention & Rehabilitation

title: Associations between dietary patterns and arterial stiffness, carotid artery intima-media thickness and atherosclerosis

ReferenceCitation: Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, Defoort C, Lovegrove JA, Drevon CA, Gibney MJ, Blaak EE, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res. 2010 Jul;51(7):1793-800. doi: 10.1194/jlr.M003046. Epub 2010 Feb 22.

title: Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome

ReferenceCitation: Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM. Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome. Am J Clin Nutr. 2009 Dec;90(6):1665-73. doi: 10.3945/ajcn.2009.28101. Epub 2009 Oct 14.

title: Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome

ReferenceCitation: Czernichow S, Vergnaud AC, Galan P, Arnaud J, Favier A, Faure H, Huxley R, Hercberg S, Ahluwalia N. Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults. Am J Clin Nutr. 2009 Aug;90(2):329-35. doi: 10.3945/ajcn.2009.27635. Epub 2009 Jun 2.