location_country:
Malaysia
Greece
Romania
Australia
Belgium
Russian Federation
Denmark
Taiwan
Ukraine
Spain
Croatia
France
Japan
Lithuania
Poland
Norway
Slovakia
Argentina
Canada
Korea, Republic of
Colombia
South Africa
Chile
Sweden
Hong Kong
Netherlands
Switzerland
Bulgaria
Singapore
Ireland
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Bosnia and Herzegovina
Serbia
Mexico
Czechia
Israel
Egypt
Belarus
Estonia
New Zealand
Latvia

location_facility: Atrium Health Carolinas Medical Center /ID# 158428

location_facility: Tsujinaka Hospital Kashiwanoha /ID# 213848

location_facility: Hospital Clinico Universitario de Salamanca /ID# 157558

location_facility: Health Pharma Professional Research S.A de C.V /ID# 170730

location_facility: National University Hospital /ID# 160667

location_facility: Universitaetsklinikum Freiburg /ID# 162030

location_facility: Hull University Teaching Hospitals NHS Trust /ID# 158761

location_facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154832

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163225

location_facility: Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207936

location_facility: Akershus universitetssykehus /ID# 169379

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160693

location_facility: Renmin Hospital of Wuhan University /ID# 214874

location_facility: St. Petersburg State Pediatric Medical University /ID# 211978

location_facility: Universita di Catanzaro Magna Graecia /ID# 212016

location_facility: Wellington Hospital (Capital and Coast District Health Board) /ID# 167225

location_facility: Hospital Universitario Central de Asturias /ID# 225349

location_facility: Houma Digestive Health Special /ID# 158264

location_facility: Southern Star Research Institute, LLC /ID# 168773

location_facility: Hospital General Universitario Alicante /ID# 159236

location_facility: Klinicki bolnicki centar Zagreb /ID# 157561

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 163226

location_facility: Digestive Disease Associates, LTD /ID# 208297

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212220

location_facility: City Clinical Hospital No. 31 /ID# 208872

location_facility: Osaka City University Hospital /ID# 160117

location_facility: Universal Axon Clinical Research /ID# 165428

location_facility: University Clinical Center Kragujevac /ID# 157049

location_facility: Medical Centre OK Clinic of International Institute of Clinical Research LLC /ID# 211998

location_facility: Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212477

location_facility: Hospital Clinic de Barcelona /ID# 157552

location_facility: Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212028

location_facility: Long Island Clinical Research /ID# 154829

location_facility: The Second Hospital of Hebei Medical University /ID# 212738

location_facility: Hospital Clinico Universitario de Valencia /ID# 209700

location_facility: Ulyanovsk State clinical hospi /ID# 200964

location_facility: Tzaneio general hospital of Piraeus /ID# 206443

location_facility: The Edith Wolfson Medical Center /ID# 217331

location_facility: Nature Coast Clinical Research - Inverness /ID# 159408

location_facility: Consultative and Diagnostic Ce /ID# 165659

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155644

location_facility: Digestive Diseases Ctr Gastro /ID# 163107

location_facility: National Hepatology and Tropical Medicine Research Institute /ID# 157874

location_facility: CHU Amiens-Picardie Site Sud /ID# 165058

location_facility: Universitair Ziekenhuis Leuven /ID# 157407

location_facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162657

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 211242

location_facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213447

location_facility: Aichi Medical University Hospital /ID# 160097

location_facility: Universitatsklinikum Munster /ID# 159344

location_facility: Praxis fuer Gastroenterologie /ID# 166150

location_facility: Hospital General Universitario Gregorio Maranon /ID# 161145

location_facility: Hospital Privado Univesitario /ID# 168076

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210705

location_facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204131

location_facility: St Vincent's University Hospit /ID# 157540

location_facility: Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171122

location_facility: The Second Xiangya Hospital of Central South University /ID# 211700

location_facility: Theageneio Anticancer Hospital /ID# 163897

location_facility: Shiga University of Medical Science Hospital /ID# 164025

location_facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211974

location_facility: Universitaetsklinikum St.Poelten /ID# 166424

location_facility: The Sixth Affiliated Hosp Sun /ID# 210784

location_facility: Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 202800

location_facility: Clin Res Inst of Michigan, LLC /ID# 169179

location_facility: Clinical Center University of Sarajevo /ID# 165139

location_facility: Ospedale Policlinico San Martino/ Università Degli Studi Di Genova /ID# 162439

location_facility: Velocity Clinical Research - Salt Lake City /ID# 161778

location_facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 161963

location_facility: Nishinomiya Munic Central Hospital /ID# 210103

location_facility: Virginia Mason - Seattle Orthapedics /ID# 155556

location_facility: West China Hospital, Sichuan University /ID# 210890

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 162531

location_facility: Gastroenterology Associates of Western Michigan, PLC /ID# 161313

location_facility: Adult Gastroenterology Associates - Main /ID# 208864

location_facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210840

location_facility: Centrul Medical Tuculanu SRL /ID# 170903

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 226574

location_facility: Yokohama City University Medical Center /ID# 163907

location_facility: Southern California Res. Ctr. /ID# 211991

location_facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154873

location_facility: CHU NANCY - Hopital Brabois Adultes /ID# 162561

location_facility: Transcarpathian Regional Clin. /ID# 167960

location_facility: Asahikawa Medical University Hospital /ID# 162848

location_facility: Yamagata University Hospital /ID# 200159

location_facility: Cotton-O'Neil Clinical Res Ctr /ID# 154722

location_facility: Great Lakes Gastroenterology Research LLC /ID# 201770

location_facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 170732

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155641

location_facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212601

location_facility: Louisana Research Center, LLC /ID# 162237

location_facility: Medizinische Hochschule Hannover /ID# 162032

location_facility: Western Connecticut Medical Group /ID# 165879

location_facility: Jinhua Municipal Central Hospital /ID# 215628

location_facility: CHU de Saint-Etienne, Hopital Nord /ID# 162562

location_facility: Praxiszentrum fuer Gastroenterologie /ID# 211966

location_facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212799

location_facility: Peak Gastroenterology Associat /ID# 165843

location_facility: South Lake Pain Institute, Inc /ID# 162808

location_facility: Texas Digestive Disease Consultants - Cedar Park /ID# 209797

location_facility: Helse More og Romsdal HF, Alesund sjukehus /ID# 212810

location_facility: Tokai University Hachioji Hospital /ID# 160098

location_facility: Clinic of Scientific Research Institute of Invalid Rehabilitation /ID# 212000

location_facility: Perm state medical university n.a. E.A. Vagner /ID# 207439

location_facility: Clinical Hosp Center Zvezdara /ID# 157052

location_facility: Clinical Associates in Researc /ID# 161323

location_facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213580

location_facility: 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 210940

location_facility: Alliance Biomedical Ural Group /ID# 200972

location_facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157553

location_facility: Oxford University Hospitals NHS Foundation Trust The John Radcliffe Hospital /ID# 158036

location_facility: Internal Medicine Department, Faculty of Medicine, AinShams University /ID# 157506

location_facility: North Shore University Hospital /ID# 168738

location_facility: Columbia Univ Medical Center /ID# 161899

location_facility: Baylor Scott & White Research Institute /ID# 159406

location_facility: South Florida Research Ph I-IV /ID# 161832

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 164540

location_facility: Hospital Maisonneuve-Rosemont /ID# 159056

location_facility: Hometown Urgent Care and Resea /ID# 170464

location_facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine /ID# 210625

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157423

location_facility: Tokyo Women's Medical University Hospital /ID# 205974

location_facility: Universitaetsklinikum Magdeburg /ID# 211843

location_facility: Hamamatsu University Hospital /ID# 205690

location_facility: Hospital Universitario Virgen Macarena /ID# 159967

location_facility: Hadassah Medical Center-Hebrew University /ID# 165914

location_facility: Phoenix VA Health Care System /ID# 162264

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210528

location_facility: Kharkiv City Clinical Hospital /ID# 165657

location_facility: Hospital Clinico Universitario San Carlos /ID# 225352

location_facility: Universitaetsklinikum Regensburg /ID# 163813

location_facility: Sapporo Medical University Hospital /ID# 163056

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170914

location_facility: Advanced Research Institute, Inc /ID# 161966

location_facility: Medical University of Vienna /ID# 158141

location_facility: Intercity Advanced Gastroentertology Center /ID# 215205

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 157187

location_facility: Tel Aviv Sourasky Medical Center /ID# 157792

location_facility: KL Ling Gastroenterology and Liver Clinic /ID# 205741

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157573

location_facility: Medical University of South Carolina /ID# 212858

location_facility: St. James University Hospital /ID# 157550

location_facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162029

location_facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167751

location_facility: Instituto de Coloproctologia /ID# 158743

location_facility: Medizinisches Versorgunszentrum Dachau /ID# 211555

location_facility: CINME Centro de Investigaciones Metabolicas /ID# 221680

location_facility: Ospedale Classificato Equiparato Sacro Cuore-Don Calabria /ID# 161299

location_facility: North Estonia Medical Centre /ID# 164326

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210724

location_facility: Vanderbilt University Medical Center /ID# 157121

location_facility: Regional Clinical Hospital #1 /ID# 200973

location_facility: Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170734

location_facility: Guangdong Provincial People's Hospital /ID# 212949

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212894

location_facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 201363

location_facility: Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157175

location_facility: Universitatsklinikum Mannheim /ID# 162031

location_facility: University of Michigan Health Systems /ID# 157126

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 163582

location_facility: Hospital Universitario San Vic /ID# 171486

location_facility: Second Multiprofile Hospital f /ID# 165702

location_facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155645

location_facility: Kuzbass Regional Clinical Hospital /ID# 200962

location_facility: Scott Shulman Medicine Professional Corporation /ID# 165906

location_facility: Queen Elizabeth University Hos /ID# 202568

location_facility: The First Affiliated Hospital of Nanchang University /ID# 211036

location_facility: Azienda Ospedaliera Univ. Meyer /ID# 167992

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 157422

location_facility: Centex Studies, Inc. - Houston /ID# 201219

location_facility: Tianjin Med Univ General Hosp /ID# 210926

location_facility: Rocky Mountain Pediatric Gastroenterology /ID# 207170

location_facility: Azienda Policlinico Universitario Umberto I /ID# 166912

location_facility: Inselspital, Universitaetsklinik /ID# 163535

location_facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211306

location_facility: Hospital Universitario Basurto /ID# 205190

location_facility: TX Clinical Research Institute /ID# 159404

location_facility: Centro Hosp de Lisboa Central /ID# 160673

location_facility: University Multiprofile Hospit /ID# 165700

location_facility: AOU Policlinico S. Orsola Malpighi /ID# 155643

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156468

location_facility: University of California, San Francisco - 16th St /ID# 157127

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211039

location_facility: Hyogo College of Medicine Hospital /ID# 160107

location_facility: Yokkaichi Hazu Medical Center /ID# 163764

location_facility: DiGiovanna Institute for Medical Education & Research /ID# 171126

location_facility: CHU Dinant Godinne - UCL Namur /ID# 157412

location_facility: Huddersfield Royal Infirmary /ID# 209570

location_facility: Medicinkliniken, Gastroenheten /ID# 163744

location_facility: Nagoya City University Hospital /ID# 160100

location_facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169384

location_facility: National Cheng Kung University Hospital /ID# 160142

location_facility: University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 157155

location_facility: The Jikei University Kashiwa Hospital /ID# 200030

location_facility: Barnsley Hospital NHS Foundation Trust /ID# 202773

location_facility: Guy's and St Thomas' NHS Found /ID# 157546

location_facility: Toho University Medical Center Sakura Hospital /ID# 160099

location_facility: United Medical Doctors - Murrieta /ID# 158300

location_facility: Gastroenterology Group Naples /ID# 165204

location_facility: Yeungnam University Medical Center /ID# 158691

location_facility: Hospital Universitario y Politecnico La Fe /ID# 157556

location_facility: Universitaetsklinikum Frankfurt /ID# 212979

location_facility: Inje University Haeundae Hospital /ID# 202518

location_facility: Plains Clinical Research Center, LLC /ID# 169718

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 154904

location_facility: Yamanashi Prefectural Central Hospital /ID# 160094

location_facility: Hospital Britanico de Buenos /ID# 168077

location_facility: Hospital Universitario La Paz /ID# 159235

location_facility: Hospital Universitario Miguel Servet /ID# 157557

location_facility: National Taiwan University Hospital /ID# 162190

location_facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213554

location_facility: The Jikei University Hospital /ID# 163209

location_facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159237

location_facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160692

location_facility: Children's Hospital of Pittsburgh of UPMC /ID# 212544

location_facility: NorthShore University HealthSystem - Evanston Hospital /ID# 158265

location_facility: Gastro Health & Nutrition - Victoria /ID# 164290

location_facility: Brandon Premier Health Care, PA/Gulf Coast Research Group, LLC /ID# 162262

location_facility: East Tallinn Central Hospital /ID# 157074

location_facility: Kitasato University Hospital /ID# 171065

location_facility: Tver Regional Clinical Hospital /ID# 206858

location_facility: Clinical Research of West Florida - Clearwater /ID# 208125

location_facility: Kyiv Railway Clinical Hosp No.2 /ID# 217366

location_facility: Kanazawa University Hospital /ID# 202258

location_facility: Fujita Health University Hospital /ID# 163234

location_facility: Svendborg Sygehus, Sygehusenhe /ID# 161525

location_facility: Hospital Universitario de Fuenlabrada /ID# 225351

location_facility: University General Hospital of Ioannina /ID# 157420

location_facility: Cleveland Clinic Main Campus /ID# 209226

location_facility: Cabinet Particular Policlinic Algomed /ID# 170900

location_facility: P. Stradins Clinical Univ Hosp /ID# 159612

location_facility: Odense Universitets Hospital /ID# 155531

location_facility: Hospital Universitario Germans Trias i Pujol /ID# 225350

location_facility: Gokeikai Ofuna Chuo Hospital /ID# 171066

location_facility: Yokohama Municipal Citizen's Hospital /ID# 207161

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 157050

location_facility: Hunter Holmes McGuire VA Medical Center /ID# 159988

location_facility: Groupe Sante CHC - Clinique du MontLegia /ID# 157404

location_facility: Krankenhaus der Barmherzigen Brueder Wien /ID# 212060

location_facility: Riga East Clinical Univ Hosp /ID# 159611

location_facility: Taichung Veterans General Hosp /ID# 160140

location_facility: Centre Recherche luniver Montr /ID# 167068

location_facility: Hanyang University Guri Hospital /ID# 158690

location_facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210858

location_facility: H-T. Centrum Medyczne - Endoterapia /ID# 212475

location_facility: Saint Louis University School of Medicine /ID# 161883

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210760

location_facility: Zagazig University Hospitals /ID# 164539

location_facility: Hospital Clinico Universitario Lozano Blesa /ID# 212525

location_facility: Volyn regional clinical hospital /ID# 206789

location_facility: Klinicki bolnicki centar Osijek /ID# 157559

location_facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167752

location_facility: Texas Digestive Disease Consultants - Cedar Park /ID# 209946

location_facility: CHU Grenoble Alpes - Hopital /ID# 212834

location_facility: Tyler Research Institute, LLC /ID# 166797

location_facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211884

location_facility: Presidio Columbus, Fondazione Policlinico Gemelli Universita Cattolica S. Cuore /ID# 155640

location_facility: East Tennessee Research Institute /ID# 168739

location_facility: GIRI Gastrointestinal Research Institute /ID# 157096

location_facility: Hospital Universitario Virgen del Rocio /ID# 225348

location_facility: Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216474

location_facility: Tokyo Medical And Dental University, Medical Hospital /ID# 160095

location_facility: Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212478

location_facility: China Medical University Hosp /ID# 160141

location_facility: University Clinical Center Serbia /ID# 157047

location_facility: Vestre viken - Baerum Sykehus /ID# 212996

location_facility: Hospital Garcia de Orta, E.P.E /ID# 160745

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159349

location_facility: Clinical Research of West Florida - Clearwater /ID# 205865

location_facility: Vitebsk Regional Advanced Clin /ID# 206778

location_facility: Public Institution Kherson City Clinical Hospital named after le.le. Karabelesha /ID# 212399

location_facility: Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162583

location_facility: Hospital Universitario de Bellvitge /ID# 208207

location_facility: University of Kentucky Chandler Medical Center /ID# 157120

location_facility: IBD Center - IRCCS Istituto Clinico Humanitas /ID# 155642

location_facility: Wojewodzki Szpital Specjalistyczny /ID# 212474

location_facility: Northwestern University Division of GI/Hepatology /ID# 158261

location_facility: Pusan National University Hospital /ID# 158695

location_facility: CHA Bundang Medical center CHA University /ID# 158698

location_facility: London Health Sciences Centre - University Hospital /ID# 157161

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 169763

location_facility: McMaster University Med Cent /ID# 157184

location_facility: Hiroshima University Hospital /ID# 160109

location_facility: Stadtisches Klinikum Braunschweig /ID# 163680

location_facility: Policlinico Universitario Campus Bio-Medico /ID# 162438

location_facility: Klinicka bolnica Dubrava Zagreb /ID# 157560

location_facility: University Clinical Centre of the Republic of Srpska /ID# 164513

location_facility: Toronto Digestive Disease Asso /ID# 157158

location_facility: Univ Hospitals Birmingham NHS Foundation trust /ID# 157545

location_facility: University Children's Hospital 'Tirsova' /ID# 211482

location_facility: Revival Research Institute, Inc /ID# 210985

location_facility: National Hospital Organization Mito Medical Center /ID# 160092

location_facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 204808

location_facility: Lviv Railway Clinical Hospital /ID# 165658

location_facility: Agaplesion Markus Krankenhaus /ID# 159345

location_facility: Centro Hosp de Tondela-Viseu /ID# 160699

location_facility: Center for Educational and Clinical Gastroenterology, Hepatology and Pancreatolo /ID# 200970

location_facility: Medical Center of LLC Medbud-Clinic /ID# 216998

location_facility: Hospital Senhora da Oliveira de Guimaraes, EPE /ID# 160737

location_facility: Taipei Veterans General Hosp /ID# 212712

location_facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 157728

location_facility: Grodno city clinical hospital #2 /ID# 205113

location_facility: University of Nebraska Med Ctr /ID# 210058

location_facility: Klinicki bolnicki centar Split /ID# 157562

location_facility: The University of Chicago Medical Center /ID# 157124

location_facility: Digestive Disease Specialists /ID# 170775

location_facility: Sjaellands Universitets Hospit /ID# 155532

location_facility: Omega Research Maitland, LLC /ID# 171082

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 154850

location_facility: Universitaetsklinikum Erlangen /ID# 159343

location_facility: Cedars-Sinai Medical Center-West Hollywood /ID# 163839

location_facility: Elisabeth Tweesteden Ziekenhuis /ID# 163632

location_facility: A.O. Per L'Emergenza Cannizzaro /ID# 161300

location_facility: University of Alberta - Zeidler Ledcor Centre /ID# 157099

location_facility: Montreal General Hospital - McGill University Health Center /ID# 157085

location_facility: Gomel Regional Clinical Hospital /ID# 205112

location_facility: West Tallinn Central Hospital /ID# 157075

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163708

location_facility: Kitasato University Kitasato Institute Hospital /ID# 160105

location_facility: Percuro Clinical Research, Ltd /ID# 161631

location_facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157424

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160096

location_facility: Evangelisches Krankenhaus Kalk /ID# 212726

location_facility: Centro Hospitalar de Entre Douro e Vouga /ID# 160672

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 210941

location_facility: UMHAT Dr Georgi Stranski EAD /ID# 203976

title: A Multicenter, Randomized, Double-Blind, Placebo Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects With Crohn's Disease

summary:
The study consists of 4 sub-studies, as follows:

Sub-study 1 (Randomized, double-blind, placebo controlled study) to evaluate the efficacy and safety of risankizumab versus placebo as maintenance therapy in participants with moderately to severely active Crohn's disease (CD) who responded to intravenous risankizumab induction treatment in Study M16-006 or Study M15-991;
Sub-study 2 (Randomized, exploratory maintenance study) to evaluate the efficacy and safety of two different dosing regimens for risankizumab as maintenance therapy in participants who responded to induction treatment in Study M16-006 or Study M15-991;
Sub-study 3 (Open-label, long-term extension study) to evaluate long-term safety of risankizumab in participants who completed Sub-study 1, Sub-study 2, another AbbVie risankizumab Crohn's disease study, or participants who responded to induction treatment in Study M16-006 or Study M15-991 with no final endoscopy due to the Covid-19 pandemic. Additional objectives are to further investigate long-term efficacy and tolerability of risankizumab;
Sub-study 4 (Open-label On Body Injector (OBI) administration and long-term extension study) to evaluate patient-reported outcomes, efficacy, safety, tolerability, and pharmacokinetics of risankizumab administered via OBI in participants who are receiving maintenance treatment with risankizumab.


design_allocation: Randomized

intervention_type: Drug

status: Completed

study_start_date_type: Actual

study_type: Interventional

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

lead_sponsor: AbbVie

enrollment_type: Actual

primary_purpose: Treatment

location_country:
Malaysia
Greece
Romania
Australia
Belgium
Russian Federation
Denmark
Taiwan
Ukraine
Spain
Croatia
France
Lithuania
Poland
Slovakia
Argentina
Canada
Korea, Republic of
Colombia
South Africa
Chile
Switzerland
Netherlands
Bulgaria
Singapore
Ireland
China
Portugal
Germany
United States
United Kingdom
Italy
Austria
Bosnia and Herzegovina
Serbia
Mexico
Czechia
Israel
Egypt
Belarus
Estonia
New Zealand
Latvia

location_facility: Aalborg Universitets Hospital /ID# 160685

location_facility: Cotton-O'Neil Clinical Res Ctr /ID# 154753

location_facility: Virginia Mason - Seattle Orthapedics /ID# 155577

location_facility: Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171121

location_facility: United Medical Doctors - Murrieta /ID# 158278

location_facility: Charite Universitaetsmedizin Berlin /ID# 212892

location_facility: Yeungnam University Medical Center /ID# 163366

location_facility: Ctr for Advanced Gastroenterol /ID# 202482

location_facility: National University Hospital /ID# 160662

location_facility: Northwest Gastroenterology Cli /ID# 158255

location_facility: Hunter Holmes McGuire VA Medical Center /ID# 159977

location_facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212534

location_facility: KL Ling Gastroenterology and Liver Clinic /ID# 205736

location_facility: Clinical Hosp Center Zvezdara /ID# 156956

location_facility: Ulyanovsk State clinical hospi /ID# 200700

location_facility: Elisabeth Tweesteden Ziekenhuis /ID# 163620

location_facility: Washington Gastroenterology Associates /ID# 162101

location_facility: Klinicki bolnicki centar Zagreb /ID# 157703

location_facility: Atrium Health Carolinas Medical Center /ID# 158364

location_facility: NorthShore University HealthSystem - Evanston Hospital /ID# 158254

location_facility: Universitaetsklinikum Magdeburg /ID# 211840

location_facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211976

location_facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159234

location_facility: Hospital Universitario Basurto /ID# 205188

location_facility: Hospital Maisonneuve-Rosemont /ID# 159058

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 169766

location_facility: Queen Elizabeth University Hos /ID# 202314

location_facility: Presidio Columbus, Fondazione Policlinico Gemelli Universita Cattolica S. Cuore /ID# 155656

location_facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154846

location_facility: University of Calgary Cumming School of Medicine Adult Cystic Fibrosis Clinic /ID# 157156

location_facility: National Cheng Kung University Hospital /ID# 160129

location_facility: Eugastro Klinische Studien GmbH /ID# 212077

location_facility: Taipei Veterans General Hosp /ID# 212711

location_facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167754

location_facility: Wojewodzki Szpital Specjalistyczny w Olsztynie, ul. Zolnierska 18 /ID# 212400

location_facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167753

location_facility: Clinical Research of West Florida - Clearwater /ID# 208127

location_facility: Hospital Universitario Virgen Macarena /ID# 159966

location_facility: Digestive Disease Specialists /ID# 170772

location_facility: Revival Research Institute, LLC /ID# 210986

location_facility: Univ Hospitals Birmingham NHS Foundation trust /ID# 157577

location_facility: Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170766

location_facility: Hospital Universitario La Paz /ID# 159232

location_facility: GIRI Gastrointestinal Research Institute /ID# 157097

location_facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 203585

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 156959

location_facility: Louisana Research Center, LLC /ID# 162239

location_facility: PennState Milton S.Hershey Med /ID# 154894

location_facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210857

location_facility: Montreal General Hospital - McGill University Health Center /ID# 157086

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209980

location_facility: Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207938

location_facility: Klinicka bolnica Dubrava Zagreb /ID# 157719

location_facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157534

location_facility: Care Access Research, Huntington Beach /ID# 213034

location_facility: Gastrointestinal Biosciences /ID# 162655

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155660

location_facility: Theageneio Anticancer Hospital /ID# 163922

location_facility: University of Nebraska Med Ctr /ID# 210056

location_facility: Perm state medical university n.a. E.A. Vagner /ID# 207438

location_facility: CHU NANCY - Hopital Brabois Adultes /ID# 162549

location_facility: TX Clinical Research Institute /ID# 159396

location_facility: Velocity Clinical Research - Salt Lake City /ID# 161775

location_facility: Hometown Urgent Care and Resea /ID# 170447

location_facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212798

location_facility: CHA Bundang Medical center CHA University /ID# 163377

location_facility: Medizinisches Versorgunszentrum Dachau /ID# 211550

location_facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160741

location_facility: Centex Studies, Inc. - Houston /ID# 201218

location_facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213446

location_facility: HonorHealth Research Institute - Shea /ID# 165825

location_facility: Tver Regional Clinical Hosp. /ID# 206586

location_facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 157720

location_facility: Gastro Health & Nutrition - Victoria /ID# 164284

location_facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 170765

location_facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210626

location_facility: Southern Star Research Institute, LLC /ID# 168772

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 154865

location_facility: West Tallinn Central Hospital /ID# 157073

location_facility: University of Kentucky Chandler Medical Center /ID# 157109

location_facility: A.O. Per L'Emergenza Cannizzaro /ID# 161303

location_facility: Universal Axon Clinical Resear /ID# 165426

location_facility: Hospital Clinico Universitario de Salamanca /ID# 157539

location_facility: Scien Ctr Coloproctology Rosme /ID# 204806

location_facility: Toronto Digestive Disease Asso /ID# 157159

location_facility: Second Multiprofile Hospital f /ID# 165699

location_facility: Digestive Dis Care/Excel Med /ID# 211776

location_facility: Percuro Clinical Research, Ltd /ID# 161635

location_facility: Hadassah Medical Center-Hebrew University /ID# 171062

location_facility: South Lake Pain Institute, Inc /ID# 162798

location_facility: Sjaellands Universitets Hospit /ID# 155537

location_facility: Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157176

location_facility: Clinical Associates in Researc /ID# 161307

location_facility: Universitaetsklinikum Tuebingen /ID# 159341

location_facility: Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev /ID# 200707

location_facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 161970

location_facility: North Shore University Hospital /ID# 168734

location_facility: Cabinet Particular Policlinic Algomed /ID# 170889

location_facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210842

location_facility: Vista Health Research LLC - Miami /ID# 212828

location_facility: London Health Sciences Centre - University Hospital /ID# 157162

location_facility: Wellington Hospital (Capital and Coast District Health Board) /ID# 167213

location_facility: Hull University Teaching Hospitals NHS Trust /ID# 158759

location_facility: Long Island Clinical Research /ID# 154843

location_facility: Plains Clinical Research Center, LLC /ID# 169712

location_facility: Hospital Senhora da Oliveira de Guimaraes, EPE /ID# 160691

location_facility: Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212018

location_facility: Ospedale Classificato Equiparato Sacro Cuore-Don Calabria /ID# 161302

location_facility: Universitaetsklinikum St.Poelten /ID# 166423

location_facility: Universita di Catanzaro Magna Graecia /ID# 212017

location_facility: Tianjin Med Univ General Hosp /ID# 210925

location_facility: Intercity Advanced Gastroentertology Center /ID# 215204

location_facility: P. Stradins Clinical Univ Hosp /ID# 159616

location_facility: Tel Aviv Sourasky Medical Center /ID# 157787

location_facility: Asklepios Westklinikum Hamburg /ID# 159336

location_facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213553

location_facility: H-T. Centrum Medyczne - Endoterapia /ID# 212458

location_facility: West China Hospital, Sichuan University /ID# 210888

location_facility: China Medical University Hosp /ID# 160130

location_facility: Precision Research Institute - Houston /ID# 201072

location_facility: University General Hospital of Ioannina /ID# 157415

location_facility: Universitaetsklinikum Freiburg /ID# 162025

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155657

location_facility: Ospedale Policlinico San Martino/ Università Degli Studi Di Genova /ID# 162434

location_facility: Centro Hospitalar de Entre Douro e Vouga /ID# 160676

location_facility: Agaplesion Markus Krankenhaus /ID# 159334

location_facility: Vidant Medical Group, d/b/a Vidant Multi-Specialty Clinic-Kinston /ID# 161109

location_facility: Regional Clinical Hospital #1 /ID# 200708

location_facility: Lenox Hill Hospital, Northwell /ID# 168466

location_facility: Barnsley Hospital NHS Foundation Trust /ID# 202772

location_facility: Centrul Medical Tuculanu SRL /ID# 170892

location_facility: Universitatsklinikum Munster /ID# 159333

location_facility: Charite Universitaetsmedizin Berlin /ID# 212218

location_facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213578

location_facility: University Clinical Centre of the Republic of Srpska /ID# 157710

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 164423

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163889

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 163604

location_facility: Tyler Research Institute, LLC /ID# 166795

location_facility: Baylor Scott & White Health - Temple /ID# 204129

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156453

location_facility: University Multiprofile Hospit /ID# 167576

location_facility: Vitebsk Regional Advanced Clin /ID# 204807

location_facility: 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209984

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 162527

location_facility: University Multiprofile Hospit /ID# 165697

location_facility: Gastroenterology Group Naples /ID# 165192

location_facility: Hospital Universitario y Politecnico La Fe /ID# 157537

location_facility: Odense Universitets Hospital /ID# 155536

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 163219

location_facility: Evangelisches Krankenhaus Kalk /ID# 212724

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170905

location_facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211882

location_facility: Peak Gastroenterology Associat /ID# 165832

location_facility: Universitaetsklinikum Erlangen /ID# 159332

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211040

location_facility: Universitaetsklinikum Regensburg /ID# 163812

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 157876

location_facility: Pusan National University Hospital /ID# 163376

location_facility: Centro Hosp de Lisboa Central /ID# 160677

location_facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169383

location_facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160732

location_facility: AOU Policlinico S.Orsola Malpighi /ID# 155659

location_facility: City Clinical Hospital No. 31 /ID# 208865

location_facility: Univerzitna nemocnica Martin /ID# 163205

location_facility: Centre Recherche luniver Montr /ID# 167070

location_facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162024

location_facility: Columbia Univ Medical Center /ID# 167545

location_facility: Praxis fuer Gastroenterologie /ID# 166148

location_facility: Taichung Veterans General Hosp /ID# 160134

location_facility: St Vincent's University Hospit /ID# 157569

location_facility: Transcarpathian Regional Clin. /ID# 167958

location_facility: Alliance Biomedical Ural Group /ID# 200703

location_facility: Clinical Research Trials of Florida, Inc. /ID# 201606

location_facility: Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212290

location_facility: Gastroenterology Associates of Western Michigan, PLC /ID# 161267

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 154919

location_facility: Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162584

location_facility: Houma Digestive Health Special /ID# 158253

location_facility: Health Pharma Professional Research S.A de C.V /ID# 170763

location_facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211304

location_facility: Riga East Clinical Univ Hosp /ID# 159615

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210706

location_facility: Klinicki bolnicki centar Split /ID# 157705

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 211241

location_facility: The Sixth Affiliated Hosp Sun /ID# 210783

location_facility: Universitaetsklinikum Frankfurt /ID# 212977

location_facility: DiGiovanna Institute for Medical Education & Research /ID# 171130

location_facility: Seffner Premier Health Care, P /ID# 162259

location_facility: IBD Center - IRCCS Istituto Clinico Humanitas /ID# 155658

location_facility: National Taiwan University Hospital /ID# 162189

location_facility: Medical University of South Carolina /ID# 212859

location_facility: CHU Grenoble Alpes - Hopital /ID# 211980

location_facility: CHU de Saint-Etienne, Hopital Nord /ID# 162550

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159338

location_facility: Hospital Clinic de Barcelona /ID# 157533

location_facility: Children's Hospital of Pittsburgh of UPMC /ID# 212543

location_facility: Clinical Center University of Sarajevo /ID# 165132

location_facility: University Clinical Center Serbia /ID# 156957

location_facility: Klinicki bolnicki centar Osijek /ID# 157704

location_facility: CliniCore International, LLC /ID# 158191

location_facility: Oxford University Hospitals NHS Foundation Trust The John Radcliffe Hospital /ID# 158039

location_facility: UMHAT Dr Georgi Stranski EAD /ID# 203975

location_facility: Clinical Research of West Florida - Clearwater /ID# 205864

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157418

location_facility: Policlinico Universitario Campus Bio-Medico /ID# 162433

location_facility: Azienda Ospedaliera Univ. Meyer /ID# 168049

location_facility: Omega Research Maitland, LLC /ID# 171080

location_facility: Inje University Haeundae Hospital /ID# 202516

location_facility: East Tallinn Central Hospital /ID# 157072

location_facility: University Clinical Centre of the Republic of Srpska /ID# 165018

location_facility: Scott Shulman Medicine Professional Corporation /ID# 165910

location_facility: Rocky Mountain Pediatric Gastroenterology /ID# 207171

location_facility: Hospital Privado Univesitario /ID# 168080

location_facility: The First Affiliated Hospital of Nanchang University /ID# 211035

location_facility: South Florida Research Ph I-IV /ID# 161825

location_facility: General Hospital Nikaias-Piraeus St. Panteleimon /ID# 157419

location_facility: Hospital Universitario Miguel Servet /ID# 157538

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163218

location_facility: Private institution Center of educational and clinical gastroenterology, hepatol /ID# 200701

location_facility: Southern California Res. Ctr. /ID# 211989

location_facility: Centro Hosp de Tondela-Viseu /ID# 160731

location_facility: Adult Gastroenterology Associates - Main /ID# 208857

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160742

location_facility: Digestive Disease Associates, LTD /ID# 208296

location_facility: Instituto de Coloproctologia /ID# 158740

location_facility: Hospital Garcia de Orta, E.P.E /ID# 160688

location_facility: Texas Digestive Disease Consultants - Cedar Park /ID# 209781

location_facility: Hospital General Universitario Gregorio Maranon /ID# 161144

location_facility: Medizinische Hochschule Hannover /ID# 162027

location_facility: Hospital Britanico de Buenos /ID# 168081

location_facility: Cleveland Clinic Main Campus /ID# 209225

location_facility: Krankenhaus der Barmherzigen Brueder Wien /ID# 211418

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210758

location_facility: Western Connecticut Medical Group /ID# 165874

location_facility: CHU Amiens-Picardie Site Sud /ID# 165056

location_facility: Internal Med Dept Ainshams uni /ID# 158630

location_facility: Centrum Medyczne LukaMed Joanna Luka /ID# 212079

location_facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154891

location_facility: Great Lakes Gastroenterology Research LLC /ID# 201774

location_facility: Praxiszentrum fuer Gastroenterologie /ID# 211965

location_facility: University Children's Hospital 'Tirsova' /ID# 211480

location_facility: Tzaneio general hospital of Piraeus /ID# 206441

location_facility: Texas Digestive Disease Consultants - Cedar Park /ID# 209945

location_facility: Medical University of Vienna /ID# 158135

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210527

location_facility: Azienda Policlinico Universitario Umberto I /ID# 166910

location_facility: Hanyang University Guri Hospital /ID# 163351

location_facility: Svendborg Sygehus, Sygehusenhe /ID# 161591

location_facility: The University of Chicago Medical Center /ID# 157113

location_facility: Universitatsklinikum Mannheim /ID# 162026

location_facility: University Clinical Center Kragujevac /ID# 156961

location_facility: East Tennessee Research Instit /ID# 168735

location_facility: Hospital Clinico Universitario de Valencia /ID# 209699

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 157417

location_facility: Vanderbilt University Medical Center /ID# 157110

ipd_sharing: Yes

study_completion_date_type: Actual

type: EudraCT Number

source: euctr

title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Assess the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment

summary: The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.

lead_sponsor_type: industriel

status_simplified: Completed


title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

summary: The objective of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior vascular endothelial growth factor receptor (VEGFR)-Targeted therapy.

status: Active, not recruiting

study_completion_date_type: Anticipated

ReferenceType: derived

ReferenceCitation: Brose MS, Robinson B, Sherman SI, Krajewska J, Lin CC, Vaisman F, Hoff AO, Hitre E, Bowles DW, Hernando J, Faoro L, Banerjee K, Oliver JW, Keam B, Capdevila J. Cabozantinib for radioiodine-refractory differentiated thyroid cancer (COSMIC-311): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2021 Aug;22(8):1126-1138. doi: 10.1016/S1470-2045(21)00332-6. Epub 2021 Jul 5.

family: Brose

full_name: Marcia S Brose

given: Marcia S

sequence: first

family: Robinson

full_name: Bruce Robinson

given: Bruce

sequence: additional

family: Sherman

full_name: Steven I Sherman

given: Steven I

family: Krajewska

full_name: Jolanta Krajewska

given: Jolanta

family: Lin

full_name: Chia-Chi Lin

given: Chia-Chi

family: Vaisman

full_name: Fernanda Vaisman

given: Fernanda

family: Hoff

full_name: Ana O Hoff

given: Ana O

family: Hitre

full_name: Erika Hitre

given: Erika

family: Bowles

full_name: Daniel W Bowles

given: Daniel W

family: Hernando

full_name: Jorge Hernando

given: Jorge

family: Faoro

full_name: Leonardo Faoro

given: Leonardo

family: Banerjee

full_name: Kamalika Banerjee

given: Kamalika

family: Oliver

full_name: Jennifer W Oliver

given: Jennifer W

family: Keam

full_name: Bhumsuk Keam

given: Bhumsuk

family: Capdevila

full_name: Jaume Capdevila

given: Jaume

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: The Lancet Oncology

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

ipd_sharing: No

lead_sponsor: Exelixis

location_country:
Romania
Australia
Belgium
Russian Federation
Taiwan
Croatia
France
Poland
Thailand
Argentina
Canada
Korea, Republic of
Hong Kong
Netherlands
Hungary
Germany
United States
United Kingdom
Italy
Austria
Brazil
Mexico
Czechia
Israel
Spain

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status_simplified: Ongoing


ReferenceCitation: Gold R, Stefoski D, Selmaj K, Havrdova E, Hurst C, Holman J, Tornesi B, Akella S, McCroskery P. Pregnancy Experience: Nonclinical Studies and Pregnancy Outcomes in the Daclizumab Clinical Study Program. Neurol Ther. 2016 Dec;5(2):169-182. Epub 2016 Jul 13.

status: Terminated

lead_sponsor: Biogen

location_country:
Greece
Romania
Australia
Russian Federation
Denmark
Ukraine
India
France
Poland
Argentina
Moldova, Republic of
Canada
Sweden
Switzerland
Hungary
Ireland
United States
Germany
United Kingdom
Italy
Brazil
Serbia
Mexico
Czechia
Israel
Georgia
Spain

acronym: EXTEND

title: A Multicenter, Open-Label, Extension Study to Evaluate the Long Term Safety and Efficacy of BIIB019, Daclizumab High Yield Process (DAC HYP), Monotherapy in Subjects With Multiple Sclerosis Who Have Completed Study 205MS301

summary:
The primary objective of the study is to assess the safety and tolerability of long-term treatment with BIIB019 (Daclizumab High Yield Process; DAC HYP) monotherapy in participants with relapsing remitting multiple sclerosis (RRMS) who completed Study 205MS301 (NCT01064401), Study 205MS203 (NCT01051349) or Study 205MS302 (NCT01462318).

Secondary objectives of this study in this study population are as follows:

To describe MS-related outcomes, including MS relapse, disability progression, MS lesion formation, and participant-reported impact of MS, following long-term treatment with DAC HYP To assess the long-term immunogenicity of DAC HYP administered by prefilled syringe (PFS) To assess the safety, tolerability, and efficacy of switching to DAC HYP in participants previously on long-term treatment with interferon β-1a (Avonex) in Study 205MS301(NCT01064401).

status_simplified: Unknown


title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Idelalisib (GS-1101) in Combination With Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas

acronym: Yosemite

summary:
The primary objective of this study is to evaluate the effect of the addition of idelalisib to rituximab on progression-free survival (PFS) in adults with previously treated indolent non-Hodgkin lymphoma (iNHL).

An increased rate of deaths and serious adverse events (SAEs) among participants with front-line chronic lymphocytic leukemia (CLL) and early-line iNHL treated with idelalisib in combination with standard therapies was observed by the independent data monitoring committee (DMC) during regular review of 3 Gilead Phase 3 studies. Gilead reviewed the unblinded data and terminated this study in agreement with the DMC recommendation and in consultation with the US Food and Drug Administration (FDA).

ipd_sharing_description: Qualified external researchers may request IPD for this study after study completion. For more information, please visit our website at http://www.gilead.com/research/disclosure-and-transparency.

lead_sponsor: Gilead Sciences

location_country:
Italy
United States
Sweden
Spain
France
Czechia
Japan
Israel
Poland
Romania
Hungary
Australia
Russian Federation
Singapore
Portugal
Germany
United Kingdom
Korea, Republic of
Taiwan

location_facility: Nizhny Novgorod Regional Clinical Hospital n.a. N.A. Semashko

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: Centro di Riferimento Oncologico di Aviano

location_facility: Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH

location_facility: Centre Hospitalier Régional Universitaire de Lille, Hôpital Claude Huriez

location_facility: Florida Cancer Specialists and Research Institute

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych z Warminsko-Mazurskim

location_facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino

location_facility: Centre Hospitalier Universitaire de Poitiers Hôpital de la Milétrie

location_facility: FSI "V.A. Almazov Federal Centre of Heart, Blood and Endocrinology of Rosmedtechnologies"

location_facility: Hospital Geral de Santo António do Centro Hospitalar do Porto

location_facility: Gemeinschaftspraxis Dres. Söling Und Siehl

location_facility: Azienda Ospedaliera Ospedali Riuniti Marche Nord

location_facility: Signal Point Clinical Research Center, LLC

location_facility: Hadassah Medical Organization, Ein Kerem

location_facility: Center for Cancer and Blood Disorders, PC

location_facility: Sverdlovsk Regional Clinical Hospital #1

location_facility: National Hospital Organization Nagoya Medical Center

location_facility: Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi

location_facility: National Hospital Organization Kumamoto Medical Center

location_facility: Azienda Ospedaliero Universitaria (AOU) "Maggiore della Carita" di Novara

location_facility: Froedtert Hospital and Medical College of Wisconsin

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: Kobe City Medical Center General Hospital

location_facility: Debreceni Egyetem Orvos-és Egészségtudományi Centrum

location_facility: Saint Petersburg I.P. Pavlov State Medical University

location_facility: Haematology and Oncology Clinics of Australia at Chermside


title: Phase 2, Single-arm, Open-label Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations and Progressed On or After Applicable Targeted Therapy and Platinum Based Chemotherapy (TROPION-Lung05)

summary: This is a study of the efficacy, pharmacokinetics, and safety of DS-1062a in participants with advanced or metastatic non-small cell lung cancer (NSCLC) with known actionable genomic alterations.

status: Recruiting

enrollment_type: Anticipated

ipd_sharing_description: De-identified individual participant data (IPD) and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/

lead_sponsor: Daiichi Sankyo, Inc.

location_country:
Italy
United States
Netherlands
France
Japan
Hungary
Spain
Germany
Korea, Republic of
Taiwan

location_facility: Koo Foundation Sun Yat-Sen Cancer Center

location_facility: Azienda Ospedaliero-Universitaria S. Orsola Malpighi

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: University of Texas MD Anderson Cancer Center

location_facility: XCancer / Regional Cancer Care Associate (Astera)

location_facility: Sarah Cannon Research Institute at Florida Cancer Center, South

location_facility: Huntsman Cancer Institute at University of Utah Huntsman Cancer Institute HCI

location_facility: Centre Hospitalier Intercommunal Toulon La Seyne sur mer Hopital Sainte-Musse

location_facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

location_facility: National Koranyi Institute for TB and Pulmonology

location_facility: Hospital Clinic i Provincial de Barcelona

location_facility: Washington University School of Medicine

location_facility: Orszagos Koranyi TBC es Pulmonologiai Intezet

location_facility: Veszprem Megyei Tudogyogyintezet Farkasgyepu

location_facility: University Hospitals Case Medical Center

location_facility: Azienda Ospedaliera Universitaria Policlinico-OVE

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

location_facility: Seoul National University Bundang Hospital

location_facility: Azienda Ospedaliera Arcispedale Santa Maria Nuova - IRCCS

location_facility: Massachusetts General Hospital Cancer Center

location_facility: Hospital General Universitario de Alicante

location_facility: Hospital Universitario Puerta de Hierro de Majadahonda

location_facility: Hopitaux Universitaire de Strasbourg- Nouvel Hopital Civil

location_facility: Sarah Cannon Research Institute at Tennessee Oncology - Chattanooga

location_facility: National Taiwan University Hospital NTUH

location_facility: Sarah Cannon Research Institute at Florida Cancer Center, North


intervention_type: Biological

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

lead_sponsor: Millennium Pharmaceuticals, Inc.

primary_purpose: Other

location_country:
Italy
France
Czechia
Poland
Israel
Hungary
Belgium
Spain
United States

acronym: Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula

location_facility: Hadassah Medical Organization, Hadassah Medical Center, Ein-

location_facility: Istituto Clinico Humanitas Rozzano, IRCCS - IBD Center

location_facility: Dartmouth Hitchcock Medical Center - Cancer Center

location_facility: Medical College of Wisconsin Hub for Collaborative Medicine - Gastroenterology and Hepatology

location_facility: MH Egeszsegugyi Kozpont - Gasztroenterologiai Osztaly

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: CHRU de Nancy -Hopital Brabois Adultes - Service d'Hepato- Gastroenterologie

location_facility: University Surgical Associates-Rhode Island Hospital

location_facility: CHRU De Lille - Hopital Claude Huriez - Hepato-Gastro-Enterologie

location_facility: Azienda Ospedaliero Universitaria S.Maria della Misericordia - Gastroenterologia

location_facility: Morristown Medical Center - Gastroenterology

location_facility: University of Kansas Sxchool of Medicine

location_facility: AOU Policlinico di Modena - Gastroenterologia

location_facility: GZA ziekenhuizen - Campus Sint-Vincentius - Gastro-enterology

location_facility: Hopital Saint Louis - Gastro-hepatoenterologie

location_facility: University of Massachusetts - colon & rectal surgery

location_facility: Mayo Clinic College of Medicine - Division of Colon and Rectal Surgery - Division of Colon and Rectal Surgery

location_facility: Shaare Zedek Medical Center - Gastroenterology

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - I. sz. Belgyogyaszati Klinika

location_facility: Hospital Universitario Puerta de Hierro Majadahonda

location_facility: Penn State Hershey Medical Center - Surgery

location_facility: Barnes-Jewish Hospital - Gastroenterology

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Virginia Mason Medical Center - Gastroenterology

title: A Follow-up of a Phase 3 Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel in the Treatment of Complex Perianal Fistula in Subjects With Crohn's Disease Who Have Participated in ADMIRE II Study

summary: The purpose of this study is to evaluate the long-term safety of a single dose of darvadstrocel in participants with Crohn's disease (CD) and complex perianal fistula by evaluation of adverse events (AEs), serious adverse events (SAEs), and adverse events of special interest (AESIs).


ipd_sharing_description:
Qualified scientific and medical researchers can request access to anonymized patient-level and study-level clinical trial data.

Access can be requested for all interventional clinical studies:

used for Marketing Authorization (MA) of medicines and new indications approved after 1 January 2014 in the European Economic Area (EEA) or the United States (US).
where Servier is the Marketing Authorization Holder (MAH). The date of the first MA of the new medicine (or the new indication) in one of the EEA Member States will be considered for this scope.

In addition, access can be requested for all interventional clinical studies in patients:

sponsored by Servier
with a first patient enrolled as of 1 January 2004 onwards
for New Chemical Entity or New Biological Entity (new pharmaceutical form excluded) for which development has been terminated before any Marketing authorization (MA) approval.

lead_sponsor: Institut de Recherches Internationales Servier

location_country:
Italy
Brazil
Spain
France
Czechia
Poland
Slovakia
Hungary
Australia
Portugal
United States
United Kingdom

location_facility: U.O.C. Psichiatria dello Sviluppo IRCCS Fondazione Stella Maris

location_facility: National Institute of Children Diseases, Department of Child Psychiatry

location_facility: Hôpital Robert Debré Service de Psychiatrie de l'enfant et de l'adolescent

location_facility: Centrum Badań Klinicznych PI-House sp. z o.o

location_facility: Faculdade de Medicina da Universidade de São Paulo - Departamento de psiquiatra

location_facility: Centre Hospitalier Charles Perrens CRA Aquitaine

location_facility: Institute of Neuropsychiatric Care, Department of Child Psychiatry

location_facility: University Hospital Brno, Department of Child Neurology

location_facility: Clínica Neurológica e Neurocirúrgica de Joinville

location_facility: University hospital of Ostrava, Department of Psychiatry

location_facility: Universidade Federal de São Paulo, Escola Paulista de Medicina

location_facility: Centre Hospitalier du Rouvray Centre de Ressources pour l'Autisme

location_facility: Hospital Universitário Walter Cantídio-Universidade Federal do Ceará

location_facility: Samodzielny Publiczny Dziecięcy Szpital Kliniczny w Warszawie Oddział Kliniczny Psychiatrii Wieku Rozwojowego

location_facility: Centro Hospitalar e Universitario de Coimbra Hospital Pediatrico

location_facility: Programma Interdipartimentale "Autismo 0-90" A.O.U. Policlinico "Gaetano Martino"

location_facility: Neuro Riabilitazione/Psicopatologia dell'età evolutiva Istituto Scientifico Medea - Bosisio Parini

location_facility: Hospital General Universitario de Alicante

location_facility: Szegedi Tudományegyetem Szent-Gyorgy Albert Klinikai Kozpont Gyermekgyógyászati Klinika Gyermek es Ifjusagpszichiátriai o

location_facility: Bekes Megyei Kozponti Korhaz Gyermek es ifjusagpszichiatriai osztaly

location_facility: Magyar Református Egyház Bethesda Gyermekkórháza

location_facility: U.O. di Neuropsichiatria Infantile Fondazione Istituto Neurologico Nazionale Casimiro Mondino Istituto di Ricovero e Cura a Carattere Scientifico

location_facility: Clinica di Neuropsichiatria dell'Infanzia e dell'Adolescenza Ospedale Pediatrico-Microcitemico

location_facility: U.O. di Neuropsichiatria Infantile Azienda Ospedaliera Universitaria Senese

location_facility: "Niepubliczny Zakład Opieki Zdrowotnej Gdańskie Centrum Zdrowia Sp. z o.o.

location_facility: Trial Tech em Pesquisas com Medicamentos Ltda

location_facility: Hôpitaux Universitaires de Strasbourg Service de Psychiatrie de l'Enfant et de l'Adolescent

location_facility: NAVICULA Centrum Diagnozy i Terapii Autyzmu w Łodzi

location_facility: Hôpital Le Vinatier CRA Rhône-Alpes, Bat 211

location_facility: The Winnicott Centre 195-197 Hathersage Road

title: Efficacy and Safety of Bumetanide Oral Liquid Formulation in Children Aged From 2 to Less Than 7 Years Old With Autism Spectrum Disorder. A 6-month Randomised, Double-blind, Placebo Controlled Multicentre Parallel Group Study to Evaluate Efficacy and Safety of Bumetanide 0.5mg Twice a Day Followed by an Open Label Active 6-month Treatment Period With Bumetanide (0.5mg Twice a Day) and a 6 Weeks Discontinuation Period After Treatment Stop.

summary: The purpose of this study is to evaluate the efficacity and the safety of bumetanide/S95008 in the improvement of Autism Spectrum Disorder core symptoms.


lead_sponsor: Merck Sharp & Dohme Corp.

location_country:
United States
France
Switzerland

acronym: Dose Ranging, Switch Study of ISL and MK-8507 Once-Weekly

location_facility: CHUV (centre hospitalier universitaire vaudois) ( Site 2605)

location_facility: DCOL Center for Clinical Research ( Site 2715)

location_facility: CHU de Toulouse - Hopital Purpan ( Site 2302)

location_facility: Saint Hope Foundation, Inc. ( Site 2716)

location_facility: Triple O Research Institute, P.A. ( Site 2712)

location_facility: Centre Hospitalier Regional du Orleans ( Site 2304)

location_facility: Universitaetsspital Zuerich ( Site 2601)

location_facility: Chatham County Health Department ( Site 2707)

location_facility: Infectious Disease Specialists Of Atlanta PC ( Site 2704)

location_facility: Inselspital Universitaetsspital Bern ( Site 2603)

location_facility: Hopitaux Universitaires de Geneve HUG ( Site 2604)

location_facility: Texas Centers for Infectious Disease Associates P.A. ( Site 2709)

location_facility: Midway Immunology and Research ( Site 2713)

location_facility: Pitie Salpetriere University Hospital-Infectious Disease - Tropical Diseases ( Site 2306)

type: Other Identifier

title: A Phase 2b, Randomized, Active-Controlled, Double-Blind, Dose-Ranging Clinical Study to Evaluate a Switch to Islatravir (ISL) and MK-8507 Once-Weekly in Adults With HIV-1 Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Once-Daily

summary: This is a randomized, controlled, double-blind, dose-ranging study evaluating a switch to islatravir (ISL) and MK-8507 once-weekly in adult participants with human immunodeficiency virus type 1 (HIV-1) who have been virologically suppressed for ≥6 months on bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) once-daily. The primary objectives are to evaluate the antiretroviral activity, safety, and tolerability of ISL with different doses of MK-8507 compared to continued BIC/FTC/TAF treatment.


location_country:
Greece
Russian Federation
Australia
Belgium
Denmark
Taiwan
Croatia
France
Japan
Poland
Canada
Korea, Republic of
South Africa
Sweden
Switzerland
Bulgaria
Hungary
Puerto Rico
Germany
United States
United Kingdom
Italy
Austria
Serbia
Czechia
Israel
New Zealand
Spain
Turkey

location_facility: Guy's and St Thomas' NHS Foundation Trust /ID# 221041

location_facility: The Chaim Sheba Medical Center /ID# 219136

location_facility: Hospital Universitario Germans Trias i Pujol /ID# 233727

location_facility: Fukushima Medical University Hospital /ID# 221877

location_facility: Gachon University Gil Medical Center /ID# 220972

location_facility: Hospital Universitario Vall d'Hebron /ID# 240979

location_facility: Fejer Megyei Szent Gyorgy Korhaz /ID# 220949

location_facility: Shonan Kamakura General Hospital /ID# 223030

location_facility: SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160

location_facility: Centre Hospitalier de CHAMBERY /ID# 223771

location_facility: Augusta University Georgia Cancer Center /ID# 219051

location_facility: Universitatsklinikum Mannheim /ID# 221529

location_facility: Tel Aviv Sourasky Medical Center /ID# 219135

location_facility: Haematologisch-Onkologische Praxis im Zentrum Augsburg /ID# 225025

location_facility: University Hospitals Birmingham NHS Foundation Trust /ID# 221334

location_facility: Moscow State budget healthcare /ID# 221116

location_facility: Azienda Ospedaliera Universitaria Federico II /ID# 224673

location_facility: Hospital Universitario Virgen del Rocio /ID# 221932

location_facility: Klinikum rechts der Isar - Technische Universitaet Muenchen /ID# 221526

location_facility: Assuta Ashdod Medical Center /ID# 225281

location_facility: Border Medical Oncology Research Unit Albury Wodonga Regional Cancer Centre /ID# 223848

location_facility: Tokyo Medical University Hospital /ID# 221540

location_facility: A.O.U. Citta della Salute e della Scienza di Torino /ID# 221223

location_facility: Juntendo University Hospital /ID# 221154

location_facility: CHU NIMES - Hopital Caremeau /ID# 219128

location_facility: Oxford University Hospitals NHS Foundation Trust /ID# 221044

location_facility: Kaohsiung Chang Gung Memorial Hospital /ID# 218985

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 220955

location_facility: Assaf Harofeh Medical Center /ID# 222972

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie /ID# 221124

location_facility: Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 225731

location_facility: China Medical University Hospital /ID# 218979

location_facility: Virginia Cancer Specialists - Fairfax /ID# 223016

location_facility: Loyola University Medical Ctr /ID# 219048

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179

location_facility: University of Miyazaki Hospital /ID# 221821

location_facility: Uniwersyteckie Centrum Kliniczne /ID# 221298

location_facility: Kanazawa University Hospital /ID# 223028

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak & Egyetemi Oktatokorhaz /ID# 220946

location_facility: Hospital Parc de Salut del Mar /ID# 220922

location_facility: Fujita Health University Hospital /ID# 221598

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 221616

location_facility: McGill University Health Center Research Institute /ID# 222614

location_facility: Wake Forest Baptist Medical Center /ID# 222899

location_facility: Universitaetsmedizin Rostock /ID# 224157

location_facility: Skane University Hospital Lund /ID# 220834

location_facility: Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 220948

location_facility: Hospital Clinico Universitario de Salamanca /ID# 221904

location_facility: General Hospital of Thessaloniki George Papanikolaou /ID# 221463

location_facility: Medizinische Universitaet Wien /ID# 220911

location_facility: Manhattan Hematology Oncology MHO Associates /ID# 223193

location_facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 219087

location_facility: Utah Cancer Specialists Salt Lake Clinic /ID# 221962

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 231059

location_facility: National Cancer Center Hospital East /ID# 226653

location_facility: Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649

location_facility: A.O.U. Policlinico G. Rodolico S.Marco- Presidio G.Rodolico /ID# 219089

location_facility: Seoul National University Hospital /ID# 219060

location_facility: The Cancer Institute at St. Francis Hospital /ID# 231782

location_facility: Dokkyo Medical University Saitama Medical Center /ID# 222334

location_facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221161

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 220947

location_facility: Ordensklinikum Linz GmbH Elisabethinen /ID# 220914

location_facility: Almazov National Medical Research Centre /ID# 221114

location_facility: Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695

location_facility: Universitaetsklinikum St. Poelten /ID# 221709

location_facility: United Lincolnshire Hospitals NHS Trust /ID# 224613

location_facility: Long Beach Memorial Medical Ct /ID# 224542

location_facility: Hospital Universitario La Paz /ID# 224813

location_facility: Tulane Medical Center - New Orleans /ID# 222940

location_facility: Indiana Blood & Marrow Transpl /ID# 221587

location_facility: Hospital of the University of Pennsylvania /ID# 219001

location_facility: CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433

location_facility: Azienda Ospedaliero Universitaria Careggi /ID# 219090

location_facility: James Paget University Hospitals NHS Foundation Trust /ID# 221219

location_facility: Hospital Clinico Universitario de Valencia /ID# 220920

location_facility: Kobe City Medical Center General Hospital /ID# 221156

location_facility: Linkou Chang Gung Memorial Ho /ID# 218982

location_facility: Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Mar /ID# 241031

location_facility: MTZ Clinical Research SP. zoo /ID# 221759

location_facility: Iwate Medical University Hospital /ID# 222044

location_facility: University General Hospital of Patras /ID# 221178

location_facility: St. Mary's Hospital Regional Cancer Center /ID# 224229

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 238438

location_facility: A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 221077

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980

location_facility: Summit Medical Group-Florham Park /ID# 222620

location_facility: Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081

location_facility: Moores Cancer Center at UC San Diego /ID# 219009

location_facility: Medizinische Universitaet Graz /ID# 220919

location_facility: Klinicki bolnicki centar Split /ID# 230800

location_facility: ASST Monza/Ospedale San Gerardo /ID# 225113

location_facility: Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115

location_facility: Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150

location_facility: Saint Louis University Cancer Center /ID# 222287

location_facility: Ege University Medical Faculty /ID# 224570

location_facility: Ottawa Hospital Research Institute /ID# 238858

location_facility: Stauferklinikum Schwaebisch Gmuend /ID# 223948

location_facility: Nippon Medical School Hospital /ID# 221676

location_facility: Hospital Universitario Central de Asturias /ID# 224815

location_facility: Vseobecna fakultni nemocnice v Praze /ID# 220969

location_facility: UMHAT Dr Georgi Stranski EAD /ID# 231650

location_facility: Sjællands Universitetshospital /ID# 224456

location_facility: Ondokuz mayis University Facul /ID# 224567

location_facility: Trakya University Medical Facu /ID# 224572

location_facility: LUX MED Onkologia - Szpital Szamocka /ID# 221265

location_facility: Niigata University Medical & Dental Hospital /ID# 223034

location_facility: OncoResearch Lerchenfeld GmbH /ID# 225034

location_facility: CHU de Nantes, Hotel Dieu -HME /ID# 219127

location_facility: Hospital Universitario 12 de Octubre /ID# 233726

location_facility: Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 221079

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 219061

location_facility: CHU Bordeaux - Hopital Haut Lévêque /ID# 222696

location_facility: Klinicki bolnicki centar Zagreb /ID# 230798

location_facility: Tula Regional Clinical Hospital /ID# 221302

location_facility: Hospital Universitario Dr. Negrin /ID# 220923

location_facility: Northwest Oncology & Hematology - Elk Grove Village /ID# 222818

location_facility: Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 221078

location_facility: University of Yamanashi Hospital /ID# 221706

location_facility: Columbus Regional Research Institute /ID# 224410

location_facility: Klinikum Wels-Grieskirchen GmbH /ID# 220915

location_facility: Hadassah Medical Center-Hebrew University /ID# 219111

location_facility: Weill Cornell Medical College /ID# 220866

location_facility: Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 221220

location_facility: American Oncology Partners of Maryland, PA /ID# 222836

location_facility: Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281

location_facility: Albert Alberts Stem Cell Transplant Centre /ID# 231556

location_facility: Inselspital, Universitätsspital Bern /ID# 223439

location_facility: Juntendo University Shizuoka Hospital /ID# 221780

location_facility: The Lady Davis Carmel Medical Center /ID# 222973

location_facility: Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 221241

location_facility: General Hospital of Athens Laiko /ID# 221175

location_facility: Ochsner Clinic Foundation-New Orleans /ID# 222777

location_facility: Pusan National University Hospital /ID# 220980

location_facility: University Clinical Center Serbia /ID# 231058

location_facility: Dana-Farber Cancer Institute /ID# 218998

location_facility: University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942

location_facility: BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346

location_facility: Hospital Universitario A Coruna - CHUAC /ID# 224617

location_facility: Taipei Veterans General Hosp /ID# 221147

title: A Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination With Ruxolitinib Versus Best Available Therapy in Subjects With Relapsed/Refractory Myelofibrosis (TRANSFORM-2)

summary:
Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body. MF disturbs the body's normal production of blood cells, causing extensive scarring in the bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, as compared to best available therapy, for adult participants with MF.

Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. The study has 2 arms - A and B. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. Adult participants with a diagnosis of relapsed/refractory (R/R) MF will be enrolled. Approximately 330 participants will be enrolled in approximately 210 sites across the world.

In Arm A, participants will receive oral navitoclax tablet once daily with oral ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT as identified by the investigator. Treatment will continue until clinical benefit is not seen, participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.


ReferenceCitation: Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P. KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma. Future Oncol. 2021 Apr;17(10):1143-1153. doi: 10.2217/fon-2020-0969. Epub 2021 Feb 3.

name: Department of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA

family: Shah

full_name: Manish A Shah

given: Manish A

name: Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Nantes, 44000, France

family: Bennouna

full_name: Jaafar Bennouna

given: Jaafar

name: Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, 277-8577, Japan

family: Doi

full_name: Toshihiko Doi

given: Toshihiko

name: Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China

family: Shen

full_name: Lin Shen

given: Lin

name: Department of Head & Neck Medical Oncology, National Cancer Center Hospital, Tokyo, 104-0045, Japan

family: Kato

full_name: Ken Kato

given: Ken

name: Department of Medical Oncology, Institut du Cancer de Montpellier & IRCM, Inserm, Université Montpellier, ICM, Montpellier, 34298, France

family: Adenis

full_name: Antoine Adenis

given: Antoine

name: Department of Radiation Oncology, Brigham & Women’s Hospital & Dana-Farber Cancer Institute, Boston, MA 02115, USA

family: Mamon

full_name: Harvey J Mamon

given: Harvey J

name: Johannes Gutenberg University Clinic Mainz, Mainz, 55101, Germany

family: Moehler

full_name: Markus Moehler

given: Markus

name: Shanghai Chest Hospital, Shanghai, 200025, China

family: Fu

full_name: Xiaolong Fu

given: Xiaolong

name: Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, 120-752, South Korea

family: Cho

full_name: Byoung Chul Cho

given: Byoung Chul

name: Department of Medical Oncology, Merck & Co., Inc., Kenilworth, NJ 07033, USA

family: Bordia

full_name: Sonal Bordia

given: Sonal

family: Bhagia

full_name: Pooja Bhagia

given: Pooja

family: Shih

full_name: Chie-Schin Shih

given: Chie-Schin

family: Desai

full_name: Anjali Desai

given: Anjali

name: Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA 02215-5450, USA

family: Enzinger

full_name: Peter Enzinger

given: Peter

journal_name: Future Oncology

oa_colors: green other

oa_host_type: publisher;repository

evidence: open (via page says license)

host_type: publisher

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

version: publishedVersion

evidence: oa repository (via pmcid lookup)

host_type: repository

license_normalized: no license

repository_normalized: PubMed Central

publisher: Future Medicine Ltd

publisher_dissemination: Future Science Ltd

publisher_group: Future Science Ltd

publisher_normalized: Future Science Ltd

intervention_type: Radiation

location_country:
Peru
Guatemala
Romania
Belgium
Russian Federation
Denmark
Taiwan
France
Japan
Argentina
Canada
Korea, Republic of
Turkey
Chile
Hong Kong
Philippines
Hungary
China
Portugal
United States
Germany
United Kingdom
Italy
Brazil
Estonia

location_facility: University of Kansas Cancer Center ( Site 0023)

location_facility: MemorialCare Health System - Long Beach Medical Center-Oncology ( Site 0691)

location_facility: Sverdlovsk Regional Oncology Hospital ( Site 0411)

location_facility: Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0392)

location_facility: Cebu Doctors University Hospital ( Site 0604)

location_facility: Tianjin Medical University Cancer Institute & Hospital ( Site 0505)

location_facility: İstanbul University Cerrahpaşa Medical Faculty ( Site 0452)

location_facility: Chang Gung Medical Foundation. Linkou ( Site 0642)

location_facility: Columbus Regional Research Institute ( Site 0047)

location_facility: Hangzhou First People's Hospital ( Site 0530)

location_facility: Charite Campus Virchow Klinikum ( Site 0250)

location_facility: Debreceni Egyetem Klinikai Kozpont ( Site 0261)

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0292)

location_facility: Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0253)

location_facility: Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0103)

location_facility: Severance Hospital Yonsei University Health System ( Site 0624)

location_facility: The Affiliated Hospital of Xuzhou Medical University ( Site 0522)

location_facility: CHU Limoges Hopital Dupuytren ( Site 0225)

location_facility: Hospital de Caridade de Ijui ( Site 0088)

location_facility: Pamela Youde Nethersole Eastern Hospital ( Site 0543)

location_facility: Chonnam National University Hwasun Hospital ( Site 0625)

location_facility: Medical institute named after Berezin Sergey ( Site 0417)

location_facility: Taichung Veterans General Hospital-Radiation Oncology ( Site 0647)

location_facility: Weill Cornell Medical College ( Site 0053)

location_facility: S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0394)

location_facility: Kaluga Regional Clinical Oncology Center ( Site 0424)

location_facility: Aichi Cancer Center Hospital ( Site 0563)

location_facility: Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0081)

location_facility: Baguio General Hospital and Medical Center ( Site 0603)

location_facility: Huai an First People s Hospital ( Site 0526)

location_facility: Hospital Nacional Arzobispo Loayza ( Site 0143)

location_facility: Centro de Cancer Nuestra Senora de la Esperanza ( Site 0104)

location_facility: Orszagos Onkologiai Intezet ( Site 0263)

location_facility: Spitalul Clinic Judetean De Urgenta Constanta ( Site 0393)

location_facility: Instituto Medico Alexander Fleming ( Site 0063)

location_facility: Koo Foundation Sun Yat-Sen Cancer Center ( Site 0644)

location_facility: National Taiwan University Hospital ( Site 0641)

location_facility: Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi ( Site 0458)

location_facility: Princess Margaret Hospital. ( Site 0542)

location_facility: National Cancer Center Hospital ( Site 0561)

location_facility: Affiliated Hospital of Jiangsu University ( Site 0524)

location_facility: Korea University Guro Hospital ( Site 0621)

location_facility: Oregon Health & Science University Center for Health & Healing 2- CHH2 ( Site 0060)

location_facility: Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0066)

location_facility: Universitaetsklinikum Muenster ( Site 0248)

location_facility: Policlinico Universitario A. Gemelli ( Site 0297)

location_facility: Hospital Regional de Concepcion ( Site 0105)

location_facility: Cancer Care Northwest - Spokane Valley ( Site 0036)

location_facility: Hospital Nossa Senhora da Conceicao ( Site 0087)

location_facility: Odense Universitetshospital ( Site 0200)

location_facility: National Cancer Center Hospital East ( Site 0562)

location_facility: ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 0283)

location_facility: Centro Investigación del Cáncer James Lind ( Site 0106)

location_facility: Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0451)

location_facility: Instituto Nacional de Enfermedades Neoplasicas ( Site 0141)

location_facility: SA Tartu Ulikooli Kliinikum ( Site 0202)

location_facility: University of Wisconsin Hospital and Clinics ( Site 0033)

location_facility: Chang Gung Med Foundation. Kaohsiung Branch ( Site 0643)

location_facility: Azienda Socio Sanitaria Territoriale di Cremona ( Site 0299)

location_facility: IRCCS Policlinico San Donato ( Site 0295)

location_facility: IRCCS Istituto Oncologico Veneto ( Site 0298)

location_facility: National Cheng Kung University Hospital ( Site 0645)

location_facility: Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 0421)

location_facility: Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0005)

location_facility: Pavlov First Saint Petersburg State Medical University ( Site 0426)

location_facility: Cambridge University Hospitals NHS Trust ( Site 0477)

location_facility: Clinica de Oncologia Reichow ( Site 0085)

location_facility: China Medical University Hospital ( Site 0646)

location_facility: Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0412)

location_facility: University College Hospital NHS Foundation Trust ( Site 0701)

location_facility: SA Pohja-Eesti Regionaalhaigla ( Site 0201)

location_facility: Shizuoka Cancer Center Hospital and Research Institute ( Site 0566)

location_facility: The Christie NHS Foundation Trust ( Site 0282)

location_facility: Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0371)

location_facility: Greater Baltimore Medical Center ( Site 0031)

location_facility: Hammersmith Hospital-Medical Oncology ( Site 0471)

location_facility: The Ottawa Hospital - Cancer Care ( Site 0008)

location_facility: GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 0430)

location_facility: The First Affiliated Hospital of Xiamen University ( Site 0538)

location_facility: Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0122)

location_facility: S.C. Radiotherapy Center Cluj S.R.L ( Site 0391)

location_facility: FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 0429)

location_facility: Centre Georges Francois Leclerc ( Site 0223)

location_facility: Ege Universitesi Tip Fakultesi ( Site 0457)

location_facility: Royal Marsden Hospital (Sutton) ( Site 0281)

location_facility: Nottingham University Hospitals NHS Trust ( Site 0476)

location_facility: Azienda Ospedaliero Universitaria Pisana - Presidio Santa Chiara ( Site 0294)

location_facility: Institut Curie - Centre Rene Huguenin ( Site 0237)

location_facility: Zhongshan Hospital Fudan University ( Site 0502)

location_facility: Princess Margaret Cancer Centre ( Site 0011)

location_facility: Institut De Cancerologie De Lorraine ( Site 0222)

location_facility: Universitaetsklinikum Koeln ( Site 0251)

location_facility: Centro Medico Integral De Cancerología (CEMIC) ( Site 0123)

location_facility: SBHI Samara Regional Clinical Oncology Dispensary ( Site 0420)

location_facility: Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0262)

type: Registry Identifier

title: A Randomized, Double-blind, Placebo-controlled Phase 3 Trial of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Receiving Concurrent Definitive Chemoradiotherapy (KEYNOTE 975)

summary:
The purpose of this study is to assess the efficacy and safety of treatment with definitive chemoradiotherapy (dCRT) + pembrolizumab (MK-3475) compared to treatment with dCRT + placebo with respect to Overall Survival (OS) and Event-free Survival (EFS) in:

participants with esophageal squamous cell carcinoma (ESCC),
participants whose tumors express Programmed Death-Ligand 1 (PD-L1) Combined Positive Score (CPS) ≥10, and
all participants.

The primary study hypotheses are that dCRT+ pembrolizumab is better than dCRT + placebo with respect to:

OS in participants with ESCC,
OS in participants whose tumors express PD-L1 CPS ≥10,
OS in all participants,
EFS in participants with ESCC,
EFS in participants whose tumors express PD-L1 CPS ≥10, and
EFS in all participants.


ipd_sharing_description: Theravance Biopharma, Inc. will not be sharing individual de-identified participant data or other relevant study documents.

lead_sponsor: Theravance Biopharma

location_country:
Greece
Romania
Australia
Russian Federation
Ukraine
Croatia
France
Poland
Korea, Republic of
South Africa
Bulgaria
Hungary
Portugal
Germany
United States
United Kingdom
Austria
Serbia
Israel
Georgia
New Zealand
Spain

acronym: DIONE

location_facility: Theravance Biopharma Investigational Site

title: A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo˗Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Induction Therapy With 2 Doses of TD-1473 in Subjects With Moderately-to-Severely Active Crohn's Disease

summary: A Phase 2 study to evaluate the efficacy, safety and tolerability of TD-1473 in subjects with moderately-to-severely active Crohn's Disease with up to 48 weeks of treatment.