title: Contribution of Positron Emission Tomography in Biological Targeting by Conformational Radiotherapy and Intensity-modulated Radiotherapy of Ear, Nose and Throat Tumors

summary:
RATIONALE: Imaging procedures, such as PET scans, may determine the extent of cancer and help doctors plan radiation therapy. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy that uses a 3-dimensional image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.

PURPOSE: This clinical trial is studying PET scans to see how well they work in patients with head and neck cancer who are undergoing 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy.

lead_sponsor: Centre Oscar Lambret


title: Role of Mitochondria in Human Bronchial Smooth Muscle Remodeling in Non Severe Asthma

acronym: MITASTHME

summary: Asthma is a frequent disease characterized by bronchial hyperresponsiveness, inflammation and remodelling. Bronchial remodelling is an abnormal repair process that contributes to the development of poorly reversible airway narrowing. It can appear very early in the evolution of the disease and involves an increased mass of bronchial smooth muscle (BSM). The mechanism of such an increase has been related with an increase in smooth muscle cell proliferation. Recently, we have demonstrated that, BSM increased proliferation is induced by an enhanced mitochondrial biogenesis in severe asthma (T. Trian et al. J Exp Med 2007). The objective of this study is to investigate the role of smooth muscle cell mitochondria in non severe asthma

status: Completed

study_completion_date_type: Actual

study_type: Interventional

primary_purpose: Health Services Research

enrollment_type: Actual

ReferenceType: background

ReferenceCitation: Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D, Ousova O, Vernejoux JM, Marthan R, Tunon-de-Lara JM, Berger P. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med. 2007 Dec 24;204(13):3173-81. Epub 2007 Dec 3.

ReferenceType: derived

ReferenceCitation: Girodet PO, Allard B, Thumerel M, Begueret H, Dupin I, Ousova O, Lassalle R, Maurat E, Ozier A, Trian T, Marthan R, Berger P. Bronchial Smooth Muscle Remodeling in Nonsevere Asthma. Am J Respir Crit Care Med. 2016 Mar 15;193(6):627-33. doi: 10.1164/rccm.201507-1404OC.

family: Girodet

full_name: Pierre-Olivier Girodet

given: Pierre-Olivier

sequence: first

family: Allard

full_name: Benoit Allard

given: Benoit

sequence: additional

family: Thumerel

full_name: Matthieu Thumerel

given: Matthieu

family: Begueret

full_name: Hugues Begueret

given: Hugues

family: Dupin

full_name: Isabelle Dupin

given: Isabelle

family: Ousova

full_name: Olga Ousova

given: Olga

family: Lassalle

full_name: Régis Lassalle

given: Régis

family: Maurat

full_name: Elise Maurat

given: Elise

family: Ozier

full_name: Annaig Ozier

given: Annaig

family: Trian

full_name: Thomas Trian

given: Thomas

family: Marthan

full_name: Roger Marthan

given: Roger

family: Berger

full_name: Patrick Berger

given: Patrick

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: American Journal of Respiratory and Critical Care Medicine

publisher: American Thoracic Society

publisher_dissemination: American Thoracic Society

publisher_group: American Thoracic Society

publisher_normalized: American Thoracic Society

lead_sponsor: University Hospital, Bordeaux

location_facility: University Hospital Bordeaux, Hôpital Haut-Lévêque

intervention_type: Procedure

lead_sponsor_type: academique

status_simplified: Completed


title: Evaluation Des Effets Anti-Stress D'un Probiotique Nomme PROBIOSTICK® Sur Des Sujets Humains Volontaires Sains Sensibles Au Stress De La Vie Quotidienne

acronym: BIOSTRESS

summary: The purpose of the the study is to determine if PROBIOSTICK® decrease stress and anxiety of people sensible to daily stress.

design_allocation: Randomized

primary_purpose: Prevention

enrollment_type: Anticipated

lead_sponsor: Institut Rosell Lallemand

intervention_type: Dietary Supplement

lead_sponsor_type: industriel


title: Phase I/II Study of Carboplatin in Association With Weekly Oral Topotecan in Patients With Metastatic or Recurrent Cervical Cancer

summary:
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

PURPOSE: This phase I/II trial is studying the side effects and best dose of topotecan when given together with carboplatin and to see how well they work in treating patients with relapsed or metastatic cervical cancer.

primary_purpose: Treatment

lead_sponsor: ARCAGY/ GINECO GROUP

intervention_type: Drug


title: Phase II Study of Allogeneic Transplant of Hematopoietic Stem Cells From a Compatible Family Donor in the Treatment of Patients Over 55 Years With Hematological Malignancies

summary:
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving antilymphocyte globulin before transplant may stop this from happening.

PURPOSE: This phase II trial is studying how well fludarabine, busulfan, and antilymphocyte globulin together with donor stem cell transplant works in treating older patients with hematological cancer.

design_allocation: Non-Randomized

lead_sponsor: Institut Paoli-Calmettes

location_facility: Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes


title: Study of the Relationship Between Sleep Quality and Daytime-Nighttime Variations of Blood Pressure and Plasma Glucose Type I

acronym: DIAPASOM

summary:
The primary objectives are to compare the mean levels of the sleep quality parameters of subjects : with a nocturnal fall of the SBP (Systolic blood pressure), DBP (diastolic blood pressure) and MAP (mean arterial pressure) over of egal to 10% (dipping subjects) and of subjects with a nocturnal fall of SBP, DBP and MAP inferior to 10% (non dipper subjects).

The secondary objectives are :

Establish correlations between:

The quality of sleep parameters
The parameters of BP variations between the diurnal and nocturnal periods and the awake periods of sleep defined in reference to polysomnography.
The glycemia levels on 24h with a glycemic holter. The parameters of the sympathic system activation evaluated in reference to the measure of the baroreflex sensibility during the awake period.

status: Terminated

primary_purpose: Screening

ReferenceCitation: Borel AL, Benhamou PY, Baguet JP, Halimi S, Levy P, Mallion JM, Pépin JL. High prevalence of obstructive sleep apnoea syndrome in a Type 1 diabetic adult population: a pilot study. Diabet Med. 2010 Nov;27(11):1328-9. doi: 10.1111/j.1464-5491.2010.03096.x.

family: Borel

full_name: A.-L. Borel

family: Benhamou

full_name: P.-Y. Benhamou

family: Baguet

full_name: J.-P. Baguet

family: Halimi

full_name: S. Halimi

given: S.

family: Levy

full_name: P. Levy

given: P.

family: Mallion

full_name: J.-M. Mallion

family: Pépin

full_name: J.-L. Pépin

journal_name: Diabetic Medicine

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

lead_sponsor: University Hospital, Grenoble

intervention_type: Biological

status_simplified: Unknown


title: A Phase IIa, Open-Label, Dose-Titration, Multicenter Study to Assess the Safety and Preliminary Efficacy of NI-0401 in Patients With Acute Cellular Renal Allograft Rejection

summary: The purpose of the study is to determine the safety and tolerability of NI-0401 and whether NI-0401 can reverse BpACR.

lead_sponsor: NovImmune SA


title: Interest of Flow Cytometry for the Diagnosis, the Follow up and SIT Arrest of Hymenoptera Venom Allergy

acronym: Cytoven

summary:
The aim of this study is to show that flow cytometry can be an accurate tool to help physicians regarding the diagnosis, the SIT decision and the SIT arrest of hymenoptera venom allergy.

75 patients having a story of reaction to hymenoptera venom will be selected for this trial.

Blood samples will be analyzed at: inclusion visit, Week 1 visit, Week 3 visit, Week 10 and Week 21 visit.

primary_purpose: Diagnostic

lead_sponsor: University Hospital, Limoges

intervention_type: Other


title: Medical and Economical Evaluation of New Diagnosis Tests of Mycobacterium Tuberculosis, Specific Immune Responses in HIV-infected Adults

acronym: IGRAVIH

summary:
Tuberculosis is a current infection during HIV infection. After infectious contact, some patients will develop tuberculosis some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) which can reactivate later.In order to prevent this tuberculosis reactivation, LTBI diagnosis screening is preconised in HIV-infected patients. This diagnosis is made till now by the tuberculin skin test (TST) but this test is not specific of TB. New blood tests (QFTB-G and T-SPOT.TB) specific po MTB infection are now sold but have not been evaluated in immunocompromised HIV-infected patients.

The primary endpoint of this study is the evaluation of the theoretic therapeutic impact of the use of IGRAS for diagnosis of LTBI in HIV-infected patients

ReferenceCitation: Bourgarit A, Baron G, Breton G, Tattevin P, Katlama C, Allavena C, Campa P, Ravaud P, Lortholary O, Carcelain G; IGRAVIH Study Group. Latent Tuberculosis Infection Screening and 2-Year Outcome in Antiretroviral-Naive HIV-Infected Patients in a Low-Prevalence Country. Ann Am Thorac Soc. 2015 Aug;12(8):1138-45. doi: 10.1513/AnnalsATS.201412-600OC. Erratum in: Ann Am Thorac Soc. 2016 Apr;13(4):576.

family: Bourgarit

full_name: Anne Bourgarit

given: Anne

family: Baron

full_name: Gabriel Baron

given: Gabriel

family: Breton

full_name: Guillaume Breton

given: Guillaume

family: Tattevin

full_name: Pierre Tattevin

given: Pierre

family: Katlama

full_name: Christine Katlama

given: Christine

family: Allavena

full_name: Clotilde Allavena

given: Clotilde

family: Campa

full_name: Pauline Campa

given: Pauline

family: Ravaud

full_name: Philippe Ravaud

given: Philippe

family: Lortholary

full_name: Olivier Lortholary

given: Olivier

family: Carcelain

full_name: Guislaine Carcelain

given: Guislaine

journal_name: Annals of the American Thoracic Society

lead_sponsor: Assistance Publique - Hôpitaux de Paris

location_facility: Service de médecine interne hôpital saint louis


title: Pulmonary Surgery and Protective Mechanical Ventilation

acronym: VPP

summary: The purpose of this trial is to evaluate the efficacy and the safety of lung protective ventilation during anesthesia in patients undergoing pneumonectomy or lobectomy for lung cancer.

ReferenceCitation: Marret E, Cinotti R, Berard L, Piriou V, Jobard J, Barrucand B, Radu D, Jaber S, Bonnet F; and the PPV study group. Protective ventilation during anaesthesia reduces major postoperative complications after lung cancer surgery: A double-blind randomised controlled trial. Eur J Anaesthesiol. 2018 Oct;35(10):727-735. doi: 10.1097/EJA.0000000000000804.

family: Marret

full_name: Emmanuel Marret

given: Emmanuel

family: Cinotti

full_name: Raphael Cinotti

given: Raphael

family: Berard

full_name: Laurence Berard

given: Laurence

family: Piriou

full_name: Vincent Piriou

given: Vincent

family: Jobard

full_name: Jacques Jobard

given: Jacques

family: Barrucand

full_name: Benoit Barrucand

given: Benoit

family: Radu

full_name: Dragos Radu

given: Dragos

family: Jaber

full_name: Samir Jaber

given: Samir

family: Bonnet

full_name: Francis Bonnet

given: Francis

journal_name: European Journal of Anaesthesiology

oa_host_type: publisher

evidence: open (via free article)

host_type: publisher

license_normalized: no license

version: publishedVersion

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

location_facility: Departement d'Anesthesie Reanimation, Hopital Tenon


title: Impact of Pregnant Women Education in Case of Overweight or Obesity on Risk of Child Overweight and Pregnancy Outcome

acronym: ETOIG

summary:
Metabolic environment of the foetus during pregnancy in obese women is altered and the child exposed at an increased risk of obesity. Rapid infancy and childhood weight gain is associated with subsequent obesity.

The purpose of the study is to test the efficacy of an educational intervention during pregnancy in obese or overweight women, on the reduction of rapid infancy weight gain in the two first years of life.

ReferenceCitation: Parat S, Nègre V, Baptiste A, Valensi P, Bertrand AM, Chollet C, Dabbas M, Altman JJ, Lapillonne A, Tréluyer JM, Elie C, Tauber M, Lorenzini F, Cosson E. Prenatal education of overweight or obese pregnant women to prevent childhood overweight (the ETOIG study): an open-label, randomized controlled trial. Int J Obes (Lond). 2019 Feb;43(2):362-373. doi: 10.1038/s41366-018-0205-z. Epub 2018 Sep 21.

family: Parat

full_name: Sophie Parat

given: Sophie

family: Nègre

full_name: Véronique Nègre

given: Véronique

family: Baptiste

full_name: Amandine Baptiste

given: Amandine

family: Valensi

full_name: Paul Valensi

given: Paul

family: Bertrand

full_name: Anne-Marie Bertrand

given: Anne-Marie

family: Chollet

full_name: Christine Chollet

family: Dabbas

full_name: Myriam Dabbas

given: Myriam

family: Altman

full_name: Jean-Jacques Altman

given: Jean-Jacques

family: Lapillonne

full_name: Alexandre Lapillonne

given: Alexandre

family: Tréluyer

full_name: Jean-Marc Tréluyer

given: Jean-Marc

family: Elie

full_name: Caroline Elie

given: Caroline

family: Tauber

full_name: Maithé Tauber

given: Maithé

family: Lorenzini

full_name: Françoise Lorenzini

given: Françoise

family: Cosson

full_name: Emmanuel Cosson

journal_name: International Journal of Obesity

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer


title: Predictors of Nocturnal Hypoventilation in Patients With Cystic Fibrosis

acronym: Sommeil

summary: The aim of the study is to identify the parameters that are associated with nocturnal hypoventilation in children and adults with cystic fibrosis. Included patients will undergo a nocturnal evaluation of their gas exchange and sleep quality by actigraphy during their annual check up. The aim is thus to identify which parameters (such as lung function parameters) are associated with nocturnal hypercapnia or hypoxemia and/or poor sleep quality

study_type: Observational

time_perspective: Cross-Sectional

intervention_type: Device


title: Intra-discal Steroid Injection for MODIC I Discopathy: A Randomized Control Trial

acronym: PREDID

summary:
To assess the efficacy on pain level at 1 month and 12 months of a steroid injection in the inter-vertebral disc for patients with chronic back pain and inflammatory discopathy on magnetic resonance imaging.

Hypothesis: delivering anti-inflammatory drugs in situ may decrease back pain in patients with inflammatory discopathy

ReferenceType: result

ReferenceCitation: Nguyen C, Boutron I, Baron G, Sanchez K, Palazzo C, Benchimol R, Paris G, James-Belin É, Lefèvre-Colau MM, Beaudreuil J, Laredo JD, Béra-Louville A, Cotten A, Drapé JL, Feydy A, Ravaud P, Rannou F, Poiraudeau S. Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial. Ann Intern Med. 2017 Apr 18;166(8):547-556. doi: 10.7326/M16-1700. Epub 2017 Mar 21.

name: From Sorbonne Paris Cité, Université Paris Descartes, Hôpitaux Universitaires Paris Centre, Groupe Hospitalier Cochin, INSERM UMR 1124, UFR Biomédicale des Saints-Pères, Assistance Publique-Hôpitaux de Paris, Hôpital Hôtel-Dieu, INSERM UMR 1153, Université Paris Diderot, Hôpitaux Universitaires Saint-Louis-Lariboisière-Fernand-Widal, Groupe Hospitalier Lariboisière, and

name: Institut Fédéatif de Recherche sur le Handicap, Paris, France, and Centre Hospitalier Régional Universitaire de Lille, Hôpital Roger Salengro, Lille, France.

family: Nguyen

full_name: Christelle Nguyen

given: Christelle

family: Boutron

full_name: Isabelle Boutron

given: Isabelle

family: Baron

full_name: Gabriel Baron

given: Gabriel

family: Sanchez

full_name: Katherine Sanchez

given: Katherine

family: Palazzo

full_name: Clémence Palazzo

given: Clémence

family: Benchimol

full_name: Raphaël Benchimol

given: Raphaël

family: Paris

full_name: Guillaume Paris

given: Guillaume

family: James-Belin

full_name: Étienne James-Belin

given: Étienne

family: Lefèvre-Colau

full_name: Marie-Martine Lefèvre-Colau

given: Marie-Martine

family: Beaudreuil

full_name: Johann Beaudreuil

given: Johann

family: Laredo

full_name: Jean-Denis Laredo

given: Jean-Denis

family: Béra-Louville

full_name: Anne Béra-Louville

given: Anne

family: Cotten

full_name: Anne Cotten

family: Drapé

full_name: Jean-Luc Drapé

given: Jean-Luc

family: Feydy

full_name: Antoine Feydy

given: Antoine

family: Ravaud

full_name: Philippe Ravaud

given: Philippe

family: Rannou

full_name: François Rannou

given: François

family: Poiraudeau

full_name: Serge Poiraudeau

given: Serge

journal_name: Annals of Internal Medicine

publisher: American College of Physicians

publisher_dissemination: American College of Physicians

publisher_group: American College of Physicians

publisher_normalized: American College of Physicians

ReferenceCitation: Daste C, Abdoul H, Foissac F, Lefèvre-Colau MM, Poiraudeau S, Rannou F, Nguyen C. Patient acceptable symptom state for patient-reported outcomes in people with non-specific chronic low back pain. Ann Phys Rehabil Med. 2020 Nov 26:101451. doi: 10.1016/j.rehab.2020.10.005. [Epub ahead of print]

family: Daste

full_name: Camille Daste

given: Camille

family: Abdoul

full_name: Hendy Abdoul

given: Hendy

family: Foissac

full_name: Frantz Foissac

journal_name: Annals of Physical and Rehabilitation Medicine


title: Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation Following Reduced Intensity Conditioning in Treating Patients With Multiple Myeloma

summary:
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect).

PURPOSE: This phase II trial is studying the side effects of giving fludarabine together with busulfan and antithymocyte globulin followed by donor stem cell transplant and to see how well it works in treating patients with multiple myeloma that has not responded to treatment.


title: Study of Effectiveness of a Ropivacaïne Continuous Sternal Infusion to Reduce Postoperative Hyperalgesia Induced by Sternotomy After Cardiac Surgery

acronym: CARDIODOLAL

summary:
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy. The high doses of intraoperative opioïds are well known to enhance postoperative hyperalgesia (HA) and a perioperative local anesthetic agent infusion is one of the therapeutic strategies used to limit this phenomena. The aim of this study was to evaluate the effectiveness of a continuous Ropivacaïne sternal infusion compared with a saline serum infusion to limit postoperative HA, pain and morphine consumption (M) after sternotomy in cardiac surgery.

This strategy could lead to lower postoperative morphine consumption and opioïd induced hyperalgesia.

location_facility: Département d'Anesthésie-Réanimation II - Hôpital cardiologique - Groupe Hospitalier Sud, CHU de Bordeaux - 4, Av de Magellan


title: SOD as Antioxidant Treatment OF ARMD

summary:
INTRODUCTION:

Acting directly on the anti-radical enzyme chain, the superoxide dismutase (SOD), a major enzyme of the anti-oxidant system, provides an alternative of the antioxidants treatment in ARMD. Its synthesis depends on the cellular oxygenated reactive species, and leads to the conversion of the superoxide ion (O2-) into hydrogen peroxide (H2O2). This compound is the cell watch guard continuously regulating a free radicals' detoxifying chain. Subsequently, by increasing the production of H2O2, the administration of SOD can trigger endogenous/internal antioxidant mechanisms.

Oral administration of SOD is possible in its galenic form, Glisodine. The purpose of this study was to evaluate the protective effect of SOD on the bilateralization of the disease.

lead_sponsor: Centre de Recherche en Nutrition Humaine Rhone-Alpe

location_facility: Centre Hospitalier Universitaire de Grenoble


title: Usefulness of Serum Procalcitonin for Predicting Serious Bacterial Infection in Febrile Infants Less Than 3 Months

acronym: PRONOUR

summary:
The primary objective is to study the value of serum procalcitonin as a predictive marker for severe bacterial infection in febrile infants.

2200 febrile infants aged less than 3 months will prospectively be included. All infants will have a measure of Procalcitonin concentrations. Comparison of the mean value of Procalcitonin concentration in infants with and without serious Bacterial infection.

Evaluation of the area under the ROC for Procalcitonin concentration.

time_perspective: Prospective

location_facility: Pediatric Emergency Depatment - Hôpital Antoine Béclère


title: Identification of the Effects of NUTRAPERF Consumption on Performance in Endurance-Type Exercise.

summary:
Exercise has numerous health benefits. Nevertheless, when exercise duration is ~45 min or longer and intensity moderate to intense, it may induce different troubles, for example: hypoglycemia, peripheral and central fatigue, muscle damages, osteoarticular injuries, inflammation, cardiovascular dysfunctions. Nutritional loading during exercise may prevent and and/or reduce some of these troubles.

In regard of recent data, we proposed a novel energy drink (NUTRAPERF®) to limit deleterious effects of long time exercise in neutral environment (outside temperature between 4 and 25°C) and to improve performance. If performance may be increased by this energy drink during long time exercise, we proposed that it consumption may also improve performance in short and sub-maximal exercise.

So, the purpose of this study is to investigate the effects of the consumption of this novel energy drink on performance during long and short time exercise. Moreover, we studied the effects of this consumption on different metabolic parameters (heart rate, oxygen consumption, respiratory quotient, ventilation, glycemia, lactatemia), on central and peripheral fatigue and on cognitive parameters.

ReferenceCitation: Peltier SL, Vincent L, Millet GY, Sirvent P, Morin JB, Guerraz M, Geyssant A, Lescuyer JF, Feasson L, Messonnier L. Effects of carbohydrates-BCAAs-caffeine ingestion on performance and neuromuscular function during a 2-h treadmill run: a randomized, double-blind, cross-over placebo-controlled study. J Int Soc Sports Nutr. 2011 Dec 7;8:22. doi: 10.1186/1550-2783-8-22.

family: Peltier

full_name: Sébastien L Peltier

given: Sébastien L

family: Vincent

full_name: Lucile Vincent

given: Lucile

family: Millet

full_name: Guillaume Y Millet

given: Guillaume Y

family: Sirvent

full_name: Pascal Sirvent

given: Pascal

family: Morin

full_name: Jean-Benoît Morin

given: Jean-Benoît

family: Guerraz

full_name: Michel Guerraz

given: Michel

family: Geyssant

full_name: André Geyssant

given: André

family: Lescuyer

full_name: Jean-François Lescuyer

given: Jean-François

family: Feasson

full_name: Léonard Feasson

given: Léonard

family: Messonnier

full_name: Laurent Messonnier

given: Laurent

bso_classification: Biology (fond.)

currency_apc_doaj: GBP

journal_name: Journal of the International Society of Sports Nutrition

oa_colors: green gold

oa_host_type: publisher;repository

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

evidence: oa repository (via pmcid lookup)

publisher_dissemination: Springer

publisher_group: Springer

lead_sponsor: Lescuyer Laboratory

location_facility: Service de Physiologie Clinique et de l'Exercice, CHU Saint-Etienne


title: French Prospective Observational Study In Intensive Care Unit (ICU) Patients Treated With Tigecycline

summary: This study will describe clinical outcome and safety data collected prospectively in subjects hospitalized in an intensive care unit (ICU) presenting with an infection for which treatment with tigecycline, alone or in combination, is planned. Data will be collected only from subjects providing informed consent.

ReferenceCitation: Bassetti M, Eckmann C, Bodmann KF, Dupont H, Heizmann WR, Montravers P, Guirao X, Capparella MR, Simoneau D, Sánchez García M. Prescription behaviours for tigecycline in real-life clinical practice from five European observational studies. J Antimicrob Chemother. 2013 Jul;68 Suppl 2:ii5-14. doi: 10.1093/jac/dkt140.

family: Bassetti

full_name: M. Bassetti

given: M.

family: Eckmann

full_name: C. Eckmann

given: C.

family: Bodmann

full_name: K. F. Bodmann

given: K. F.

family: Dupont

full_name: H. Dupont

given: H.

family: Heizmann

full_name: W. R. Heizmann

given: W. R.

family: Montravers

full_name: P. Montravers

given: P.

family: Guirao

full_name: X. Guirao

given: X.

family: Capparella

full_name: M. R. Capparella

given: M. R.

family: Simoneau

full_name: D. Simoneau

given: D.

family: Sanchez Garcia

full_name: M. Sanchez Garcia

journal_name: Journal of Antimicrobial Chemotherapy

evidence: open (via free pdf)

publisher: Oxford University Press (OUP)

publisher_dissemination: Oxford University Press

publisher_group: Oxford University Press

publisher_normalized: Oxford University Press

ReferenceCitation: Guirao X, Sánchez García M, Bassetti M, Bodmann KF, Dupont H, Montravers P, Heizmann WR, Capparella MR, Simoneau D, Eckmann C. Safety and tolerability of tigecycline for the treatment of complicated skin and soft-tissue and intra-abdominal infections: an analysis based on five European observational studies. J Antimicrob Chemother. 2013 Jul;68 Suppl 2:ii37-44. doi: 10.1093/jac/dkt143.

ReferenceCitation: Montravers P, Bassetti M, Dupont H, Eckmann C, Heizmann WR, Guirao X, García MS, Capparella MR, Simoneau D, Bodmann KF. Efficacy of tigecycline for the treatment of complicated skin and soft-tissue infections in real-life clinical practice from five European observational studies. J Antimicrob Chemother. 2013 Jul;68 Suppl 2:ii15-24. doi: 10.1093/jac/dkt141.

lead_sponsor: Wyeth is now a wholly owned subsidiary of Pfizer


title: Prospective Study on Postoperative Weight Bearing After Opening Wedge High Tibial Osteotomy (HTO): Early Weight Bearing Versus Delayed. Open Labelled Randomized Clinical Study

summary:
The study analyzes the consequences of weight bearing after an HTO in a population of young patient with medial osteoarthritis (immediate weight bearing versus two month weight bearing). The two options are usually used so the protocol belongs to the intermediate care evaluation category.

The IKS (International Knee Society) score at one year follow up is the first outcome. The aim of the study is to highlight that the option early weight bearing (immediately in postoperative) is equal to the option delayed weight bearing.

primary_purpose: Other

ReferenceCitation: Lansdaal JR, Mouton T, Wascher DC, Demey G, Lustig S, Neyret P, Servien E. Early weight bearing versus delayed weight bearing in medial opening wedge high tibial osteotomy: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017 Dec;25(12):3670-3678. doi: 10.1007/s00167-016-4225-8. Epub 2016 Jul 1.

family: Lansdaal

full_name: Joris Radboud Lansdaal

given: Joris Radboud

family: Mouton

full_name: Tanguy Mouton

given: Tanguy

family: Wascher

full_name: Daniel Charles Wascher

given: Daniel Charles

family: Demey

full_name: Guillaume Demey

given: Guillaume

family: Lustig

full_name: Sebastien Lustig

given: Sebastien

family: Neyret

full_name: Philippe Neyret

given: Philippe

family: Servien

full_name: Elvire Servien

given: Elvire

journal_name: Knee Surgery, Sports Traumatology, Arthroscopy

lead_sponsor: Hospices Civils de Lyon


title: CERTICOEUR a Secondary Prevention Study of Skin Cancers in Heart Transplant Patients. An Open Labelled Randomized Everolimus vs Calcineurin Inhibitors Multicenter Trial

acronym: CERTICOEUR

summary: Heart transplant is a recognized therapeutic strategy in refractory heart failure. Its success is however hampered by severe cancer occurrence and recurrence. The new m-tor inhibiting drugs Sirolimus and Everolimus have shown potential for reducing the incidence of cancer in animal models. They are potent immunosuppressant, antiproliferative and antiangiogenic drugs. This open labelled randomized multicenter study aims at evaluating the beneficial antineoplastic effect of Everolimus in 159 heart transplant patients suffering of recurrent skin cancer. Primary objective is to demonstrate a reduction in the number of new skin cancers. Secondary end point will be time of recurrence, incidence of non skin cancer, graft function following switch (including death), renal function evolution following calcineurin inhibitors reduction or withdrawal, Everolimus tolerance profile, schemes of calcineurin inhibitors reduction management in centers.

status: Unknown status


type: Other Identifier

title: An Open Multicentric Randomized Clinical Trial Assessing the Impact of Motivational Interviewing on Cannabis Consumption in Patients With Psychiatric Disease

acronym: SCHIZOCAN

summary: Schizophrenia is a severe mental illness with a lifetime morbidity risk close to 1 %, involving both genetic and environmental risk factors. Prospective studies have shown that heavy use of cannabis in adolescence moderately increases the risk of developing schizophrenia. Many data have also suggested that the co-occurrence of cannabis abuse in patients with schizophrenia has a deleterious impact on the clinical outcome of schizophrenia. Cannabis abuse by schizophrenic patients is a significant public health problem for which there is no empirically validated treatment. We are presently studying the efficiency of motivational therapy on cannabis consumption in patients with schizophrenia.

intervention_type: Behavioral


title: Assessment of Reduction of Cord Blood Transplantation Toxicity by Using Reduced Intensity Conditioning in Patients With Acute Myeloid Leukemia.

acronym: MINICORD

summary: Multicentric evaluation of the reduction of unrelated cord blood transplantation (UCBT) toxicity by using reduced intensity conditioning (RIC) in patients with acute myeloid leukaemia.UCBT related mortality and morbidity were limiting factors for the development of this procedure in adults. Non myeloablative conditioning regimen showed promising results and prospective evaluation has to be developed to confirm these retrospective data.

ReferenceCitation: Rio B, Chevret S, Vigouroux S, Chevallier P, Fürst S, Sirvent A, Bay JO, Socié G, Ceballos P, Huynh A, Cornillon J, Françoise S, Legrand F, Yakoub-Agha I, Michel G, Maillard N, Margueritte G, Maury S, Uzunov M, Bulabois CE, Michallet M, Clement L, Dauriac C, Bilger K, Gluckman E, Ruggeri A, Buzyn A, Nguyen S, Simon T, Milpied N, Rocha V; Société Française de Greffe de Moelle et de Thérapie Cellulaire and Eurocord. Decreased nonrelapse mortality after unrelated cord blood transplantation for acute myeloid leukemia using reduced-intensity conditioning: a prospective phase II multicenter trial. Biol Blood Marrow Transplant. 2015 Mar;21(3):445-53. doi: 10.1016/j.bbmt.2014.11.009. Epub 2014 Nov 18.

family: Rio

full_name: Bernard Rio

given: Bernard

family: Chevret

full_name: Sylvie Chevret

given: Sylvie

family: Vigouroux

full_name: Stéphane Vigouroux

given: Stéphane

family: Chevallier

full_name: Patrice Chevallier

given: Patrice

family: Fürst

full_name: Sabine Fürst

given: Sabine

family: Sirvent

full_name: Anne Sirvent

given: Anne

family: Bay

full_name: Jacques-Olivier Bay

given: Jacques-Olivier

family: Socié

full_name: Gérard Socié

given: Gérard

family: Ceballos

full_name: Patrice Ceballos

family: Huynh

full_name: Anne Huynh

family: Cornillon

full_name: Jérôme Cornillon

given: Jérôme

family: Françoise

full_name: Sylvie Françoise

family: Legrand

full_name: Faezeh Legrand

given: Faezeh

family: Yakoub-Agha

full_name: Ibrahim Yakoub-Agha

given: Ibrahim

family: Michel

full_name: Gérard Michel

family: Maillard

full_name: Natacha Maillard

given: Natacha

family: Margueritte

full_name: Geneviève Margueritte

given: Geneviève

family: Maury

full_name: Sébastien Maury

given: Sébastien

family: Uzunov

full_name: Madalina Uzunov

given: Madalina

family: Bulabois

full_name: Claude Eric Bulabois

given: Claude Eric

family: Michallet

full_name: Mauricette Michallet

given: Mauricette

family: Clement

full_name: Laurence Clement

given: Laurence

family: Dauriac

full_name: Charles Dauriac

given: Charles

journal_name: Biology of Blood and Marrow Transplantation

title: Decreased Nonrelapse Mortality after Unrelated Cord Blood Transplantation for Acute Myeloid Leukemia Using Reduced-Intensity Conditioning: A Prospective Phase II Multicenter Trial

location_facility: Département d'Hématologie et d'Oncologie Médicale, Hôtel-Dieu


title: Concordance Entre l'échographie du Genou et la Radiographie Standard Dans la détection Des Calcifications Dans le Cadre de la Chondrocalcinose Articulaire

acronym: chondro

summary: Prospective study with an echography of the 2 knees and radiography of the 2 knees (front and profile) for each patient. If found calcification on ultrasound further examination with ultrasound wrists, hips and shoulders.


title: Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty

acronym: KETAMINE

summary:
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

location_facility: Service d'anesthesie-reanimation - Hôpital Bicêtre


title: Magnetic Resonance Diabetic Cardiac Stress Imaging : MRDIABETICS

acronym: MRDiabetics

summary: The aim of the study is to assess the efficacy of cardiac MRI to detect coronary disease in diabetic patients. Cardiac MRI will be compared to myocardial scintigraphy with is the method being used in current practice. The investigators believe that cardiac MRI will be as efficient if not better that myocardial scintigraphy to detect tight coronary artery stenosis with the advantage of providing no radiation to the patient. Moreover, the investigators believe that cardiac MR will add additional information regarding possible undetected myocardial infarction.


title: Effects of Daily Consumption of a Probiotic on the Evolution of Infectious Episodes (ENT, Gastro-intestinal and Pulmonary), in Subject Aged 60 Years or Over, During Winter.

summary: We put forward that probiotics have an effect on infectious episodes evolution in subjects aged 60 years or over. The main objective of this research is to observe the effect of consumption of the probiotic on the average number of days with infectious episodes.


acronym: Mannitol et trauma crânien

type: EudraCT Number

source: euctr

title: Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension

summary: Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?


title: Phase I Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study With Multiple Ascending Doses of ORM-12741

summary: The purpose of this study is to evaluate the safety and tolerability of escalating multiple doses of ORM-12741 in healthy volunteers

lead_sponsor: Orion Corporation, Orion Pharma


title: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Study to Assess the Efficacy and Safety of SBG on Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiation Therapy With or Without Chemotherapy

summary: The purpose of this study is to evaluate the efficacy and safety of SBG vs placebo on oral mucositis in head and neck cancer patients undergoing radiation therapy.

lead_sponsor: Biotec Pharmacon ASA


title: Assessment of Efficiency of Nebulized Ceftazidime and Amikacin in Treatment of Ventilator Associated Pneumonia Caused by Pseudomonas Aeruginosa

summary: Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics. In experimental models, nebulization of antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and increases lung bacterial killing. The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients.

lead_sponsor: Groupe Hospitalier Pitie-Salpetriere

location_facility: Intensive care unit, Department of anesthesiology, La pitie-Salpetriere hospital


title: Recurrence of Bladder Cancer After Transurethral Resection With Hexvix

summary: This is a randomised, comparative, multicentre study to determine if the early recurrence rate of intermediate-risk bladder cancer is similar in subjects treated with multiple instillations of mitomycin C after resection conducted under white light cystoscopy (group A) and subjects treated with 1 instillation of mitomycin C after resection conducted under white light and blue light cystoscopy (group B).

status: Withdrawn

lead_sponsor: GE Healthcare


title: Comparison Between Monoclonal Antibody CD20 Treatment (Rituximab (mabthéra))and General Corticotherapy Treatment in Patients With Pemphigus

acronym: Rituximab 3

summary:
Pemphigus is a severe and sometimes life-threatening disease with a mortality rate between 5 and 10 percent depending on the severity of disease and age of patients.

The standard of care is high doses of corticosteroids (CS) (usually, prednisone, 1 to 1.5. mg/kg/day, which are often associated with immunosuppressive drugs i.e., azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine, although only one randomised study has demonstrated the superiority of the combination of corticosteroids and immunosuppressive drugs as compared to corticosteroids alone (9). Because of the low frequency of the disease, control trials are difficult to conduct. Evaluation of the different treatment regimens proposed, i;e; corticosteroids alone, CS and immunosuppressive drugs, IV immunoglobulins or new therapeutic regimens such as rituximab (an anti-CD20 monoclonal antibody directed against B- lymphocytes) or immunoadsorbtion.

ReferenceCitation: Mignard C, Maho-Vaillant M, Golinski ML, Balayé P, Prost-Squarcioni C, Houivet E, Calbo SB, Labeille B, Picard-Dahan C, Konstantinou MP, Chaby G, Richard MA, Bouaziz JD, Duvert-Lehembre S, Delaporte E, Bernard P, Caux F, Alexandre M, Ingen-Housz-Oro S, Vabres P, Quereux G, Dupuy A, Debarbieux S, Avenel-Audran M, D'Incan M, Bédane C, Bénéton N, Jullien D, Dupin N, Misery L, Machet L, Beylot-Barry M, Dereure O, Sassolas B, Benichou J, Joly P, Hébert V; French Study Group on Autoimmune Bullous Skin Diseases. Factors Associated With Short-term Relapse in Patients With Pemphigus Who Receive Rituximab as First-line Therapy: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA Dermatol. 2020 May 1;156(5):545-552. doi: 10.1001/jamadermatol.2020.0290.

name: Centre de référence des maladies bulleuses auto-immunes, Department of Dermatology, Rouen University Hospital, Normandie University, INSERM U1234, Rouen, France

family: Mignard

full_name: Claire Mignard

given: Claire

family: Maho-Vaillant

full_name: Maud Maho-Vaillant

given: Maud

family: Golinski

full_name: Marie-Laure Golinski

given: Marie-Laure

name: Department of Biostatistics and Clinical Research, Rouen University Hospital, Rouen, France

family: Balayé

full_name: Pierre Balayé

given: Pierre

name: Centre de référence des maladies bulleuses auto-immunes, Avicenne Hospital, Assistance Publique–Hôpitaux de Paris, Department of Dermatology, University of Paris 13, Bobigny, France

family: Prost-Squarcioni

full_name: Catherine Prost-Squarcioni

given: Catherine

family: Houivet

full_name: Estelle Houivet

given: Estelle

family: Calbo

full_name: Sé´bastien Calbo

given: Sé´bastien

name: Department of Dermatology, University of Saint Etienne, Saint Etienne, France

family: Labeille

full_name: Bruno Labeille

given: Bruno

name: Department of Dermatology, Bichat Hospital, University of Paris X, Paris, France

family: Picard-Dahan

full_name: Catherine Picard-Dahan

name: Department of Dermatology, University of Toulouse, Toulouse, France

family: Konstantinou

full_name: Maria Polina Konstantinou

given: Maria Polina

name: Department of Dermatology, University of Amiens, Amiens, France

family: Chaby

full_name: Guillaume Chaby

given: Guillaume

name: Assistance Publique des Hôpitaux de Marseille, Department of Dermatology, Aix Marseille University, UMR 911, INSERM CRO2, Marseille, France

family: Richard

full_name: Marie-Aleth Richard

given: Marie-Aleth

name: Department of Dermatology, St Louis Hospital, Paris 7 Sorbonne Paris Cité University, Paris, France

family: Bouaziz

full_name: Jean-David Bouaziz

given: Jean-David

name: Department of Dermatology, University of Lille, Lille, France

family: Duvert-Lehembre

full_name: Sophie Duvert-Lehembre

given: Sophie

family: Delaporte

full_name: Emmanuel Delaporte

given: Emmanuel

name: Department of Dermatology, University of Reims, Reims, France

family: Bernard

full_name: Philippe Bernard

given: Philippe

family: Caux

full_name: Frédéric Caux

given: Frédéric

family: Alexandre

full_name: Marina Alexandre

given: Marina

name: Department of Dermatology, Assistance Publique–Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France

family: Ingen-Housz-Oro

full_name: Saskia Ingen-Housz-Oro

given: Saskia

name: Department of Dermatology, Dijon University Hospital, Dijon, France

family: Vabres

full_name: Pierre Vabres

name: Department of Dermatology, University of Nantes, Nantes, France

family: Quereux

full_name: Gaëlle Quereux

given: Gaëlle

name: Department of Dermatology, University of Rennes, Rennes, France

family: Dupuy

full_name: Alain Dupuy

given: Alain

name: Department of Dermatology, Centre Hospitalier Lyon Sud, Pierre Bénite, Lyon, France

family: Debarbieux

full_name: Sébastien Debarbieux

name: Department of Dermatology, University of Angers, Angers, France

name: Department of Dermatology, University of Clermont-Ferrand, Clermont-Ferrand, France

name: Department of Dermatology, University of Limoges, Limoges, France

name: Department of Dermatology, Le Mans General Hospital, Le Mans, France

name: Department of Dermatology, Edouard Herriot Hospital, Lyon Claude Bernard University, Lyon, France

name: Department of Dermatology, University of Paris V, Paris, France

name: Department of Dermatology, Brest University Hospital, Brest, France

name: Department of Dermatology, Tours University Hospital, Tours, France

name: Department of Dermatology, University of Bordeaux, Bordeaux, France

name: Department of Dermatology, University of Montpellier, Montpellier, France

name: Department of Internal Medicine, Brest University Hospital, Brest, France

name: for the French Study Group on Autoimmune Bullous Skin Diseases

ReferenceCitation: Joly P, Maho-Vaillant M, Prost-Squarcioni C, Hebert V, Houivet E, Calbo S, Caillot F, Golinski ML, Labeille B, Picard-Dahan C, Paul C, Richard MA, Bouaziz JD, Duvert-Lehembre S, Bernard P, Caux F, Alexandre M, Ingen-Housz-Oro S, Vabres P, Delaporte E, Quereux G, Dupuy A, Debarbieux S, Avenel-Audran M, D'Incan M, Bedane C, Bénéton N, Jullien D, Dupin N, Misery L, Machet L, Beylot-Barry M, Dereure O, Sassolas B, Vermeulin T, Benichou J, Musette P; French study group on autoimmune bullous skin diseases. First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial. Lancet. 2017 May 20;389(10083):2031-2040. doi: 10.1016/S0140-6736(17)30070-3. Epub 2017 Mar 22.


title: Impact of a Counselling System Coupled With a Computer Prescribing System to Optimize the Use of the Drugs for Old Subjects Having Renal Function Impairment

acronym: Ordoclic-IR

summary: To evaluate the quality of orders for target drugs in old patients with impaired renal function, hospitalized or living in long stay units, and to improve these practices by means of a counselling system coupled to a computer prescribing system

location_facility: hopital Charles Foix et Université Paris 6


title: Inflammatory Response to Hydroxyurea Therapy in Sickle Cell Disease

summary: In sickle cell disease (SCD), polymerisation of haemoglobin S and the resulting shape change of the red blood cells (RBC) lead to vascular occlusion and severe painful crises. Permanent inflammatory state and abnormal RBC adhesion to the endothelium trigger these phenomenon. Hydroxyurea (HU) is the only drug that has been shown to reduce clinical severity of SCD, and this was initially attributed to the stimulation of foetal haemoglobin (HbF). However, the clinical response does not correlate consistently with the degree and time of HbF increment, suggesting that HU clinical benefits may involve other mechanisms such as the induction of natural anti-inflammatory response via the hypothalami-pituitary-adrenal axis.


title: Surfactant Disorders Associated With Chronic Lung Disease in Children.

acronym: APSE

summary: Interstitial lung diseases (ILD) in children represent a heterogeneous group of rare and not well defined disorders. Genetic abnormalities of surfactant proteins B (SFTPB) and more recently C (SFTPC) have been shown to be related to these pathologies. However, variability in the lung disease phenotype suggests the involvement of other surfactant-associated genes such as ABCA3 (ATP-binding cassette, sub-family A, member, 3). Thus, the aim of this project is: 1) to assess the prevalence of SFTPC mutation in children with chronic lung diseases, 2) to precise clinical and radiological features of children with SFTPC mutation, and 3) to identify environmental or genetic factors that may explain the extreme variability of this disease.

ReferenceCitation: Epaud R, Delestrain C, Louha M, Simon S, Fanen P, Tazi A. Combined pulmonary fibrosis and emphysema syndrome associated with ABCA3 mutations. Eur Respir J. 2014 Feb;43(2):638-41. doi: 10.1183/09031936.00145213. Epub 2013 Oct 17.

family: Epaud

full_name: R. Epaud

given: R.

family: Delestrain

full_name: C. Delestrain

given: C.

family: Louha

full_name: M. Louha

given: M.

family: Simon

full_name: S. Simon

given: S.

family: Fanen

full_name: P. Fanen

given: P.

family: Tazi

full_name: A. Tazi

given: A.

journal_name: European Respiratory Journal

oa_colors: green hybrid

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: The Pennsylvania State University - CiteSeer X

repository_normalized: CiteSeerX

publisher: European Respiratory Society (ERS)

publisher_dissemination: European Respiratory Society

publisher_group: European Respiratory Society

publisher_normalized: European Respiratory Society

ReferenceCitation: Delestrain C, Flamein F, Jonard L, Couderc R, Guillot L, Fanen P, Epaud R. [Lung diseases in children associated with inherited disorders of surfactant metabolism]. Rev Pneumol Clin. 2013 Aug;69(4):183-9. doi: 10.1016/j.pneumo.2013.05.002. Epub 2013 Jul 12. Review. French.

family: Flamein

full_name: F. Flamein

given: F.

family: Jonard

full_name: L. Jonard

given: L.

family: Couderc

full_name: R. Couderc

family: Guillot

full_name: L. Guillot

journal_name: Revue de Pneumologie Clinique

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

title: Pathologies respiratoires de l’enfant associées à des anomalies héréditaires du métabolisme du surfactant

ReferenceCitation: Flamein F, Riffault L, Muselet-Charlier C, Pernelle J, Feldmann D, Jonard L, Durand-Schneider AM, Coulomb A, Maurice M, Nogee LM, Inagaki N, Amselem S, Dubus JC, Rigourd V, Brémont F, Marguet C, Brouard J, de Blic J, Clement A, Epaud R, Guillot L. Molecular and cellular characteristics of ABCA3 mutations associated with diffuse parenchymal lung diseases in children. Hum Mol Genet. 2012 Feb 15;21(4):765-75. doi: 10.1093/hmg/ddr508. Epub 2011 Nov 7.

full_name: Florence Flamein

given: Florence

family: Riffault

full_name: Laure Riffault

given: Laure

family: Muselet-Charlier

full_name: Céline Muselet-Charlier

given: Céline


title: Molecular Diagnosis of Primary Ciliary Dyskinesia

acronym: DCP

summary: Primary ciliary dyskinesia is an inherited respiratory disease caused by various functional and ultrastructural abnormalities of respiratory cilia. The genetic heterogeneity underlying PCD is extremely important and only few genes are clearly implicated in PCD. Their mutations account for about 20% of patients. For all the other PCD patients, the genes responsible for their ciliary defect remain to be identify.

ReferenceCitation: Bush A, Cole P, Hariri M, Mackay I, Phillips G, O'Callaghan C, Wilson R, Warner JO. Primary ciliary dyskinesia: diagnosis and standards of care. Eur Respir J. 1998 Oct;12(4):982-8. Review.

ReferenceCitation: Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala MA, Knowles MR. Primary ciliary dyskinesia: diagnostic and phenotypic features. Am J Respir Crit Care Med. 2004 Feb 15;169(4):459-67. Epub 2003 Dec 4.

ReferenceCitation: Holzmann D, Ott PM, Felix H. Diagnostic approach to primary ciliary dyskinesia: a review. Eur J Pediatr. 2000 Jan-Feb;159(1-2):95-8. Review.

ReferenceCitation: Afzelius BA, Gargani G, Romano C. Abnormal length of cilia as a possible cause of defective mucociliary clearance. Eur J Respir Dis. 1985 Mar;66(3):173-80.

ReferenceCitation: Escudier E, Escalier D, Pinchon MC, Boucherat M, Bernaudin JF, Fleury-Feith J. Dissimilar expression of axonemal anomalies in respiratory cilia and sperm flagella in infertile men. Am Rev Respir Dis. 1990 Sep;142(3):674-9.

ReferenceCitation: Verra F, Fleury-Feith J, Boucherat M, Pinchon MC, Bignon J, Escudier E. Do nasal ciliary changes reflect bronchial changes? An ultrastructural study. Am Rev Respir Dis. 1993 Apr;147(4):908-13.

ReferenceCitation: Wodehouse T, Kharitonov SA, Mackay IS, Barnes PJ, Wilson R, Cole PJ. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur Respir J. 2003 Jan;21(1):43-7.

ReferenceCitation: Arnal JF, Flores P, Rami J, Murris-Espin M, Bremont F, Pasto I Aguilla M, Serrano E, Didier A. Nasal nitric oxide concentration in paranasal sinus inflammatory diseases. Eur Respir J. 1999 Feb;13(2):307-12.

ReferenceCitation: Karadag B, James AJ, Gültekin E, Wilson NM, Bush A. Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia. Eur Respir J. 1999 Jun;13(6):1402-5.

ReferenceCitation: Rossman CM, Lee RM, Forrest JB, Newhouse MT. Nasal cilia in normal man, primary ciliary dyskinesia and other respiratory diseases: analysis of motility and ultrastructure. Eur J Respir Dis Suppl. 1983;127:64-70.

ReferenceCitation: Chilvers MA, Rutman A, O'Callaghan C. Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults. Thorax. 2003 Apr;58(4):333-8.

ReferenceCitation: Tamalet A, Clement A, Roudot-Thoraval F, Desmarquest P, Roger G, Boulé M, Millepied MC, Baculard TA, Escudier E. Abnormal central complex is a marker of severity in the presence of partial ciliary defect. Pediatrics. 2001 Nov;108(5):E86.

ReferenceCitation: Moore A, Escudier E, Roger G, Tamalet A, Pelosse B, Marlin S, Clément A, Geremek M, Delaisi B, Bridoux AM, Coste A, Witt M, Duriez B, Amselem S. RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa. J Med Genet. 2006 Apr;43(4):326-33. Epub 2005 Jul 31.

ReferenceCitation: Krawczyński MR, Witt M. PCD and RP: X-linked inheritance of both disorders? Pediatr Pulmonol. 2004 Jul;38(1):88-9.

ReferenceCitation: Pennarun G, Escudier E, Chapelin C, Bridoux AM, Cacheux V, Roger G, Clément A, Goossens M, Amselem S, Duriez B. Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia. Am J Hum Genet. 1999 Dec;65(6):1508-19.

ReferenceCitation: Porter ME. Axonemal dyneins: assembly, organization, and regulation. Curr Opin Cell Biol. 1996 Feb;8(1):10-7. Review.

ReferenceCitation: Porter ME, Sale WS. The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility. J Cell Biol. 2000 Nov 27;151(5):F37-42. Review.

ReferenceCitation: Zariwala M, Noone PG, Sannuti A, Minnix S, Zhou Z, Leigh MW, Hazucha M, Carson JL, Knowles MR. Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. Am J Respir Cell Mol Biol. 2001 Nov;25(5):577-83.

ReferenceCitation: Guichard C, Harricane MC, Lafitte JJ, Godard P, Zaegel M, Tack V, Lalau G, Bouvagnet P. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). Am J Hum Genet. 2001 Apr;68(4):1030-5. Epub 2001 Feb 23.

ReferenceCitation: Dutcher SK. Chlamydomonas reinhardtii: biological rationale for genomics. J Eukaryot Microbiol. 2000 Jul-Aug;47(4):340-9.

ReferenceCitation: Kamiya R. Functional diversity of axonemal dyneins as studied in Chlamydomonas mutants. Int Rev Cytol. 2002;219:115-55. Review.

ReferenceCitation: Pennarun G, Chapelin C, Escudier E, Bridoux AM, Dastot F, Cacheux V, Goossens M, Amselem S, Duriez B. The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia. Hum Genet. 2000 Dec;107(6):642-9.

ReferenceCitation: Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE. Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia. Genomics. 2001 Feb 15;72(1):21-33.

ReferenceCitation: Pennarun G, Bridoux AM, Escudier E, Dastot-Le Moal F, Cacheux V, Amselem S, Duriez B. Isolation and expression of the human hPF20 gene orthologous to Chlamydomonas PF20: evaluation as a candidate for axonemal defects of respiratory cilia and sperm flagella. Am J Respir Cell Mol Biol. 2002 Mar;26(3):362-70.

ReferenceCitation: Omran H, Häffner K, Völkel A, Kuehr J, Ketelsen UP, Ross UH, Konietzko N, Wienker T, Brandis M, Hildebrandt F. Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate gene. Am J Respir Cell Mol Biol. 2000 Nov;23(5):696-702.

ReferenceCitation: Olbrich H, Häffner K, Kispert A, Völkel A, Volz A, Sasmaz G, Reinhardt R, Hennig S, Lehrach H, Konietzko N, Zariwala M, Noone PG, Knowles M, Mitchison HM, Meeks M, Chung EM, Hildebrandt F, Sudbrak R, Omran H. Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nat Genet. 2002 Feb;30(2):143-4. Epub 2002 Jan 14.

ReferenceCitation: Bartoloni L, Blouin JL, Pan Y, Gehrig C, Maiti AK, Scamuffa N, Rossier C, Jorissen M, Armengot M, Meeks M, Mitchison HM, Chung EM, Delozier-Blanchet CD, Craigen WJ, Antonarakis SE. Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10282-6. Epub 2002 Jul 25.

ReferenceCitation: Volz A, Boyle JM, Cann HM, Cottingham RW, Orr HT, Ziegler A. Report of the Second International Workshop on Human Chromosome 6. Genomics. 1994 May 15;21(2):464-72.

ReferenceCitation: Meeks M, Walne A, Spiden S, Simpson H, Mussaffi-Georgy H, Hamam HD, Fehaid EL, Cheehab M, Al-Dabbagh M, Polak-Charcon S, Blau H, O'Rawe A, Mitchison HM, Gardiner RM, Chung E. A locus for primary ciliary dyskinesia maps to chromosome 19q. J Med Genet. 2000 Apr;37(4):241-4.

ReferenceCitation: Witt M, Wang Yf, Wang S, Sun Ce, Pawlik J, Rutkiewicz E, Zebrak J, Diehl SR. Exclusion of chromosome 7 for Kartagener syndrome but suggestion of linkage in families with other forms of primary ciliary dyskinesia. Am J Hum Genet. 1999 Jan;64(1):313-8.

ReferenceCitation: Geremek M, Zietkiewicz E, Diehl SR, Alizadeh BZ, Wijmenga C, Witt M. Linkage analysis localises a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25. J Med Genet. 2006 Jan;43(1):e1.

ReferenceCitation: Jeganathan D, Chodhari R, Meeks M, Faeroe O, Smyth D, Nielsen K, Amirav I, Luder AS, Bisgaard H, Gardiner RM, Chung EM, Mitchison HM. Loci for primary ciliary dyskinesia map to chromosome 16p12.1-12.2 and 15q13.1-15.1 in Faroe Islands and Israeli Druze genetic isolates. J Med Genet. 2004 Mar;41(3):233-40.

ReferenceCitation: Blouin JL, Meeks M, Radhakrishna U, Sainsbury A, Gehring C, Saïl GD, Bartoloni L, Dombi V, O'Rawe A, Walne A, Chung E, Afzelius BA, Armengot M, Jorissen M, Schidlow DV, van Maldergem L, Walt H, Gardiner RM, Probst D, Guerne PA, Delozier-Blanchet CD, Antonarakis SE. Primary ciliary dyskinesia: a genome-wide linkage analysis reveals extensive locus heterogeneity. Eur J Hum Genet. 2000 Feb;8(2):109-18.

ReferenceCitation: Chilvers MA, Rutman A, O'Callaghan C. Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia. J Allergy Clin Immunol. 2003 Sep;112(3):518-24.

ReferenceCitation: Rutland J, Cox T, Dewar A, Cole P. Screening for ciliary dyskinesia - a spectrum of defects of motility and structure. Eur J Respir Dis Suppl. 1983;127:71-7.

ReferenceCitation: de Iongh RU, Rutland J. Ciliary defects in healthy subjects, bronchiectasis, and primary ciliary dyskinesia. Am J Respir Crit Care Med. 1995 May;151(5):1559-67.

ReferenceCitation: Cazeneuve C, Ajrapetyan H, Papin S, Roudot-Thoraval F, Geneviève D, Mndjoyan E, Papazian M, Sarkisian A, Babloyan A, Boissier B, Duquesnoy P, Kouyoumdjian JC, Girodon-Boulandet E, Grateau G, Sarkisian T, Amselem S. Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. Am J Hum Genet. 2000 Nov;67(5):1136-43. Epub 2000 Oct 3.

location_facility: Hôpital A. Trousseau, Service de Génétique et d'Embryologie Médicales


title: Evaluation of Angiogenic Potential in Sickle Cell Disease. CARACTERIZATION of Endothelial Progenitor Cells

acronym: DREPANOPEC

summary: Sickle Cell Disease (SCD) is the most prevalent genetic disease of haemoglobin.The underlying abnormality in the red blood cell (RBC) of SCD is the presence of abnormal sickle cell hemoglobin (HbS), which, when deoxygenated, becomes relatively insoluble, forms aggregates with other hemoglobin molecules within the RBC and causes rigid deformation of the cell. Acute pain vaso-occlusive crisis, strokes and acute chest syndrome are the main acute complications, sometimes life-threatening, often leading to organic and functional squeal. Although the common SS form of SCD is a unique gene disorder, the range of the clinical severity is remarkably wide and striking, suggesting that clinical polymorphism is due to modifier genes and environmental factors.Most of the research efforts have been focused on the biology of haemoglobin and of the red cells. Meanwhile, the complex pathophysiology of SCD is undoubtedly influenced by the many physiologic functions of the vascular wall. In line with this hypothesis are several reports of increased circulating levels of endothelium-derived surface molecules in SCD patients suggesting marked endothelial stress in SCD. Similarly, other processes that involve the endothelium, such as leukocyte adhesion and activation, may play a role in vascular occlusion. This accumulation of data raises the unanswered question of the mechanisms of endothelium maintenance and regeneration in SCD. Through these mechanisms, it is likely that function or dysfunction of the vascular endothelium contributes to the overall vascular pathobiology of this disease, which includes recurrent vaso-occlusions, stroke, leg ulcers, chronic organ ischemic damages, and neovascularizing retinopathy that affect nearly one-half (48%) of the surviving patients by the fifth decade.Thus, our groups have combined their respective clinical and biological expertises to test the hypothesis that SCD is a condition of specific endothelial stress and dysfunction upon chronic and Paracystic abnormal interactions with circulating cells and abnormal oxygen delivery to tissues. Specifically, we hypothesize that chronic endothelial stress with detachment of activated endothelial cells require increases mobilisation of the Endothelial Progenitor Cells (EPCs) that maintain endothelial homeostasis to avoid major thromboembolic events and vasospasm. Inappropriate mobilisation or maturation of the EPCs in SCD may participate to the severity of the disease.

location_facility: Hopital Tenon, Assistance Publique Hôpitaux de Paris


title: An Educational and Exercise Program as Secondary Prevention of Recurrent Lower Back Pain in Healthcare Workers: A Randomized, Controlled, 2-year Follow-up Study.

acronym: PRESLO

summary:
At Lyon University Medical Center, back problems are the leading cause of sick leave. The course of lower back pain is usually relatively short (recovery occurs within 4 to 6 weeks in 90% of cases). However, about 5-10% develop chronic lower back pain. Although this is a relatively small group, the economic consequences are enormous (accounting for 70 to 80% of the total cost of lower back pain).

Nowadays, some very general training sessions are offered to workers at Lyon University Medical Center, irrespective of their lower back pain status. These very general training sessions are mostly preventive and primary in nature (like back school program) despite the fact that these people already have a history of lower back pain, the main risk factor of recurrence and chronic pain.

Since the 1980, some multidisciplinary functional restoration programs have been advised as a strategy for secondary and tertiary prevention of lower back pain.

The purpose of this randomized controlled trial is to assess the effectiveness of physical exercise combined with an educational program and self-led exercise for Lyon University Medical Center workers with lower back pain. We hope this intervention will reduce the risk of recurrence and chronic lower back pain.

ReferenceCitation: Chaléat-Valayer E, Denis A, Abelin-Genevois K, Zelmar A, Siani-Trebern F, Touzet S, Bergeret A, Colin C, Fassier JB. Long-term effectiveness of an educational and physical intervention for preventing low-back pain recurrence: a randomized controlled trial. Scand J Work Environ Health. 2016 Jun 1;42(6):510-519. doi: 10.5271/sjweh.3597. Epub 2016 Oct 3.

family: ChalÃ©at-Valayer

full_name: Emmanuelle ChalÃ©at-Valayer

given: Emmanuelle

family: Denis

full_name: AngÃ©lique Denis

given: AngÃ©lique

family: Abelin-Genevois

full_name: Kariman Abelin-Genevois

given: Kariman

family: Zelmar

full_name: AmÃ©lie Zelmar

given: AmÃ©lie

family: Siani-Trebern

full_name: Fabienne Siani-Trebern

given: Fabienne

family: Touzet

full_name: Sandrine Touzet

given: Sandrine

family: Bergeret

full_name: Alain Bergeret

family: Colin

full_name: Cyrille Colin

given: Cyrille

family: Fassier

full_name: Jean-Baptiste Fassier

given: Jean-Baptiste

currency_apc_doaj: EUR

journal_name: Scandinavian Journal of Work, Environment & Health

evidence: open (via page says license)

publisher: Scandinavian Journal of Work, Environment and Health

ReferenceCitation: Denis A, Zelmar A, Le Pogam MA, Chaleat-Valayer E, Bergeret A, Colin C. The PRESLO study: evaluation of a global secondary low back pain prevention program for health care personnel in a hospital setting. Multicenter, randomized intervention trial. BMC Musculoskelet Disord. 2012 Nov 27;13:234. doi: 10.1186/1471-2474-13-234.

full_name: Angélique Denis

given: Angélique

full_name: Amélie Zelmar

given: Amélie

family: Le Pogam

full_name: Marie-Annick Le Pogam

given: Marie-Annick

family: Chaleat-Valayer

full_name: Emmanuelle Chaleat-Valayer

journal_name: BMC Musculoskeletal Disorders


title: Immunological Consequences of CARD15/NOD2 Mutations in Crohn's Disease

acronym: PLAC

summary: The project is based on adult and paediatric cohorts among the largest ones in Paris and located at Saint Louis and Robert Debré hospitals. Experiments will be performed at INSERM Unit U843 in collaboration with the department of immunology and statistics, Robert Debré Hospital.

primary_purpose: Basic Science


title: Premature Ovarian Failure : Genetic and Physiopathologic Analysis

acronym: GéNIOP

summary:
Premature Ovarian Failure (POF), syndrome observed in young woman, present consequences on hormonal and leads at definitive infertility. It's a rare and complex syndrome and for this reason, we propose to initiate a collaborative team network to understand better his genetic and physiopathology.

We are going to realize a global study of this syndrome with clinical and fundamentals approaches. We wish that this project allows us to understand better the physiopathology of this rare disease. Finally, POF responsible genes identification is the base for future development of therapeutics approaches.

study_completion_date_type: Anticipated


title: Effect of TNF-blocker Injections Spacing on Rheumatoid Arthritis Inflammatory Activity in Patients in Clinical Remission or Low Disease Activity

acronym: STRASS

summary:
Remission is nowadays the recommended therapeutic objective in rheumatoid arthritis. Once this objective is achieved thanks to TNF-blockers, the optimal therapeutic strategy remains unclear, either therapeutic maintenance or progressive DMARD tapering (with a non quantified risk of disease flare).

STRASS is a 2-arm randomized controlled trial aiming to compare these 2 strategies (DMARD maintenance or progressive spacing of TNF-blocker injections) in terms of remission maintenance, relapse risk, safety issues and economic consequences during 18 months.

The inclusion period is 18 months, between September 2008 and February 2010.

ReferenceCitation: Fautrel B, Pham T, Alfaiate T, Gandjbakhch F, Foltz V, Morel J, Dernis E, Gaudin P, Brocq O, Solau-Gervais E, Berthelot JM, Balblanc JC, Mariette X, Tubach F. Step-down strategy of spacing TNF-blocker injections for established rheumatoid arthritis in remission: results of the multicentre non-inferiority randomised open-label controlled trial (STRASS: Spacing of TNF-blocker injections in Rheumatoid ArthritiS Study). Ann Rheum Dis. 2016 Jan;75(1):59-67. doi: 10.1136/annrheumdis-2014-206696. Epub 2015 Jun 23.

family: Fautrel

full_name: Bruno Fautrel

given: Bruno

family: Pham

full_name: Thao Pham

given: Thao

family: Alfaiate

full_name: Toni Alfaiate

given: Toni

family: Gandjbakhch

full_name: Frédérique Gandjbakhch

given: Frédérique

family: Foltz

full_name: Violaine Foltz

given: Violaine

family: Morel

full_name: Jacques Morel

given: Jacques

family: Dernis

full_name: Emmanuelle Dernis

family: Gaudin

full_name: Philippe Gaudin

given: Philippe

family: Brocq

full_name: Olivier Brocq

given: Olivier

family: Solau-Gervais

full_name: Elisabeth Solau-Gervais

given: Elisabeth

family: Berthelot

full_name: Jean-Marie Berthelot

given: Jean-Marie

family: Balblanc

full_name: Jean-Charles Balblanc

given: Jean-Charles

family: Mariette

full_name: Xavier Mariette

given: Xavier

family: Tubach

full_name: Florence Tubach

journal_name: Annals of the Rheumatic Diseases

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

title: Step-down strategy of spacing TNF-blocker injections for established rheumatoid arthritis in remission: results of the multicentre non-inferiority randomised open-label controlled trial(STRASS: Spacing of TNF-blocker injections in Rheumatoid ArthritiS Study)

location_facility: Service de rhumatologie / Groupe hospitalier Pitié Salpêtrière


title: The ITALIC Study Is There A LIfe for DES After Discontinuation of Clopidogrel : The ITALIC Study

acronym: ITALIC

summary:
Background

Drug-eluting stents (DES) have been extremely successful in reducing restenosis and the need for repeat revascularization procedures in patients who undergo PCI. The potential increased incidence of late stent thrombosis prompted cardiologists to prolong the use of dual anti-platelet therapy after the one year duration recommended by the recent ESC guidelines. However, while the premise that the cardiologists should put all their patients on dual clopidogrel-aspirin regimen for life sounds the easy way, it is an unrealistic goal because of the potential increase of bleeding complications and of the healthcare cost increase. The recent possibility to monitor aspirin with bedside assays offers a real opportunity to compare in good aspirin responder patients the two strategies: aspirin-clopidogrel regimen versus mono-aspirin regimen and to respond to the key question: can the investigators switch from dual to single antiplatelet therapy after six months in good aspirin responder patients ? Study National, multicenter, randomised prospective open group comparison of dual clopidogrel-ASA versus single ASA regimen after six months, in good ASA responder patients treated with DES (name: XIENCE) implantation.

End point Primary: At 12 months: death, myocardial infarction, repeat urgent revascularization, stroke requiring a new hospitalisation and major bleedings.

Secondary: Incidence at 24 and 36 months after drug eluting stent(name: XIENCE) implantation, of the same composite endpoint and incidence at 12, 24 and 36 months of minor bleeding complications Participating centres: 60 french centers

Date of study beginning: November 2008 Duration of inclusion: 9 months Duration of study: 45 months

lead_sponsor: French Cardiology Society


title: Characterization of At-risk Population and Prognosis Factors for SACRO-coccygeal Teratoma in CURRARINO Syndrome. A Clinical, Molecular and Pathological Study.

acronym: Currarino

summary: Contribute to support hypothesis of relationships between genes involve in oncogenesis and those involve in embryological development.

location_facility: Hôpital Necker-Enfants Malades Pediatric Surgery Department


title: Evaluation of Efficacy and Cost of Two Monitoring Strategies for Public Clinical Research - OPTIMON: Optimisation of Monitoring for Clinical Research Studies

acronym: OPTIMON

summary: OPTIMON will compare the efficacy and the cost of two monitoring strategies: one based on the classic standards of quality assurance, and the other one being a priori "optimized" on the main scientific and regulatory principles.

ReferenceCitation: Liénard JL, Quinaux E, Fabre-Guillevin E, Piedbois P, Jouhaud A, Decoster G, Buyse M; European Association for Research in Oncology. Impact of on-site initiation visits on patient recruitment and data quality in a randomized trial of adjuvant chemotherapy for breast cancer. Clin Trials. 2006;3(5):486-92.

lead_sponsor: University Hospital, Bordeaux

location_facility: Unité de Soutien Méthodologique à la Recherche Clinique et Epidémiologique du CHU de Bordeaux


title: Clinical Evaluation by Physical Therapist of Swallowing Disorders as a Predictor of Extubation Failure in Patients Intubated Orotracheally for Over 6 Days

acronym: EVAKIN

summary: Patients with failed extubation stay significantly longer in an intensive care unit (ICU) and have a higher mortality rate, than those intubated successfully. Reintubation is associated with life-threatening complications and a poor prognosis. Functional respiratory tests are frequently used as weaning parameters, however, they are not accurate enough to predict extubation failure. The incidence of swallowing dysfunction is underestimated, mainly among patients whose intubation lasts longer than 48 h.We previously observed that the assessment of the swallowing function and oropharyngeal motricity, conducted by the physiotherapist before extubation could be helpful for making decisions to extubate patients intubated for over 6 days. The objective of this study is to validate a scale previously devised and used for physiotherapist bedside evaluation of the swallowing function and oropharyngeal motricity, among patients intubated for over 6 days, to determine whether this scale is a good predictor of airway secretion-related extubation failure.Expected results : to validate a scale previously devised called " physiotherapist evaluation of the swallowing function and oropharyngeal motricity before extubation" by the mean of a multicentric study. In our hypothesis the clinical parameters studied could be predictive of extubation failure. Then, this evaluation could help the medical decision in the choice of the good time for extubation. The final objective is to lower the mortality related to extubation failure.

ReferenceCitation: Houzé MH, Deye N, Mateo J, Mégarbane B, Bizouard F, Baud FJ, Payen de la Garanderie D, Vicaut E, Yelnik AP; EVAKIN Study Group. Predictors of Extubation Failure Related to Aspiration and/or Excessive Upper Airway Secretions. Respir Care. 2020 Apr;65(4):475-481. doi: 10.4187/respcare.07025. Epub 2019 Nov 19.

family: Houzé

full_name: Marie-Hélène Houzé

given: Marie-Hélène

family: Deye

full_name: Nicolas Deye

given: Nicolas

family: Mateo

full_name: Joaquim Mateo

given: Joaquim

family: Mégarbane

full_name: Bruno Mégarbane

family: Bizouard

full_name: Françoise Bizouard

given: Françoise

family: Baud

full_name: Frédéric J Baud

given: Frédéric J

family: Payen de la Garanderie

full_name: Didier Payen de la Garanderie

given: Didier

family: Vicaut

full_name: Eric Vicaut

given: Eric

family: Yelnik

full_name: Alain P Yelnik

given: Alain P

journal_name: Respiratory Care

publisher: Daedalus Enterprises

publisher_dissemination: Daedalus Enterprises

publisher_group: Daedalus Enterprises

publisher_normalized: Daedalus Enterprises


summary:
The purpose of this study is to determine the pharmacokinetic profile of Revlimid® in patients presenting with Multiple Myeloma and impaired renal function, the safety of Revlimid® in the enrolled patients population.

and evaluate the efficacy of Revlimid®-Dexamethasone combination in patients presenting MM and impaired renal function at completion of 3 cycles of treatment.

lead_sponsor: Poitiers University Hospital


title: Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements

acronym: LoopObese

summary: Pharmacokinetic models for anesthetic agents are questionable. The objective of the study is to compare the propofol and remifentanil doses required to maintain the bispectral index in the range 40-60 in two groups of patients: obese patients and lean patients

ReferenceCitation: Liu N, Chazot T, Genty A, Landais A, Restoux A, McGee K, Laloë PA, Trillat B, Barvais L, Fischler M. Titration of propofol for anesthetic induction and maintenance guided by the bispectral index: closed-loop versus manual control: a prospective, randomized, multicenter study. Anesthesiology. 2006 Apr;104(4):686-95.

ReferenceCitation: Servin F, Farinotti R, Haberer JP, Desmonts JM. Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study. Anesthesiology. 1993 Apr;78(4):657-65.

ReferenceCitation: Liu N, Lory C, Assenzo V, Cocard V, Chazot T, Le Guen M, Sessler DI, Journois D, Fischler M. Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison. Br J Anaesth. 2015 Apr;114(4):605-14. doi: 10.1093/bja/aeu401. Epub 2014 Dec 10.

family: Liu

full_name: N. Liu

given: N.

family: Lory

full_name: C. Lory

given: C.

family: Assenzo

full_name: V. Assenzo

given: V.

family: Cocard

full_name: V. Cocard

family: Chazot

full_name: T. Chazot

given: T.

family: Le Guen

full_name: M. Le Guen

given: M.

family: Sessler

full_name: D.I. Sessler

family: Journois

full_name: D. Journois

given: D.

family: Fischler

full_name: M. Fischler

journal_name: British Journal of Anaesthesia

evidence: open (via crossref license)

license: elsevier-specific: oa user license

license_normalized: elsevier-specific

repositories_institution: The Pennsylvania State University - CiteSeer X

title: Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison †

lead_sponsor: Hopital Foch


title: A Phase IIA Trial Testing the Efficacy of Bortezomib (Velcade(R)) in Patients With Advanced Waldenström Macroglobulinemia

summary: This trial is designed to evaluate the efficacy and toxicity of Bortezomib , an inhibitor of proteasome used in multiple myeloma, in patients with advanced Waldenström's Macroglobulinemia disease.


ReferenceCitation: Nougarede N, Bisceglia H, Rozières A, Goujon C, Boudet F, Laurent P, Vanbervliet B, Rodet K, Hennino A, Nicolas JF. Nine μg intradermal influenza vaccine and 15 μg intramuscular influenza vaccine induce similar cellular and humoral immune responses in adults. Hum Vaccin Immunother. 2014;10(9):2713-20. doi: 10.4161/hv.29695.

family: Nougarede

full_name: Nolwenn Nougarede

given: Nolwenn

family: Bisceglia

full_name: Hélène Bisceglia

given: Hélène

family: Rozières

full_name: Aurore Rozières

given: Aurore

family: Goujon

full_name: Catherine Goujon

given: Catherine

family: Boudet

full_name: Florence Boudet

given: Florence

family: Laurent

full_name: Philippe Laurent

given: Philippe

family: Vanbervliet

full_name: Beatrice Vanbervliet

given: Beatrice

family: Rodet

full_name: Karen Rodet

given: Karen

family: Hennino

full_name: Ana Hennino

given: Ana

family: Nicolas

full_name: Jean-François Nicolas

given: Jean-François

journal_name: Human Vaccines & Immunotherapeutics

license: cc-by-nc

license_normalized: cc-by-nc

publisher: Informa UK Limited

publisher_dissemination: Informa

publisher_group: Informa

publisher_normalized: Informa

lead_sponsor: Sanofi Pasteur, a Sanofi Company

title: Evaluation of the Cellular, Humoral and Mucosal Immune Response in Adults and Elderly Subjects Vaccinated Either With an Inactivated Influenza Vaccine Administered Via the Intradermal Route or an Inactivated Influenza Vaccine Administered Via the Intramuscular Route

summary:
To further characterize the immune responses induced after an influenza vaccination performed either via the ID or the IM routes in two clearly distinct populations.

Objectives:

To describe the immune response per age group and vaccine group after vaccination.
To describe the safety of the vaccines per age group and per vaccine group after vaccination.


title: Influence of Walking on Spontaneous Physical Activity and on Lipid Oxidation Following Dietary Treatment of Obesity

summary: The purpose of this study is to determine whether walking exercise after dietary treatment of obesity is associated with a decrease of the daily spontaneous physical activity and\or with an increase of the time spent in sedentary activities. Our hypothesis is that the practice of walking as an exercise during the phase of weight stability following the dietary treatment of obesity leads to a reduction of spontaneous physical activity and\or to an increase in the time spent in sedentary activities.

ReferenceCitation: Brage S, Brage N, Franks PW, Ekelund U, Wong MY, Andersen LB, Froberg K, Wareham NJ. Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. J Appl Physiol (1985). 2004 Jan;96(1):343-51. Epub 2003 Sep 12.

ReferenceCitation: Fogelholm M, Kukkonen-Harjula K. Does physical activity prevent weight gain--a systematic review. Obes Rev. 2000 Oct;1(2):95-111. Review.

ReferenceCitation: Froidevaux F, Schutz Y, Christin L, Jéquier E. Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period. Am J Clin Nutr. 1993 Jan;57(1):35-42.

ReferenceCitation: Jéquier E, Schutz Y. Long-term measurements of energy expenditure in humans using a respiration chamber. Am J Clin Nutr. 1983 Dec;38(6):989-98.

ReferenceCitation: Kraemer WJ, Volek JS, Clark KL, Gordon SE, Incledon T, Puhl SM, Triplett-McBride NT, McBride JM, Putukian M, Sebastianelli WJ. Physiological adaptations to a weight-loss dietary regimen and exercise programs in women. J Appl Physiol (1985). 1997 Jul;83(1):270-9.

ReferenceCitation: Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science. 1999 Jan 8;283(5399):212-4.

ReferenceCitation: Levine JA, Schleusner SJ, Jensen MD. Energy expenditure of nonexercise activity. Am J Clin Nutr. 2000 Dec;72(6):1451-4.

ReferenceCitation: Nicklas BJ, Rogus EM, Goldberg AP. Exercise blunts declines in lipolysis and fat oxidation after dietary-induced weight loss in obese older women. Am J Physiol. 1997 Jul;273(1 Pt 1):E149-55.

ReferenceCitation: van Aggel-Leijssen DP, Saris WH, Hul GB, van Baak MA. Short-term effects of weight loss with or without low-intensity exercise training on fat metabolism in obese men. Am J Clin Nutr. 2001 Mar;73(3):523-31.

ReferenceCitation: van Aggel-Leijssen DP, Saris WH, Wagenmakers AJ, Hul GB, van Baak MA. The effect of low-intensity exercise training on fat metabolism of obese women. Obes Res. 2001 Feb;9(2):86-96.

ReferenceCitation: Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol. 1990 Nov;259(5 Pt 1):E650-7.

lead_sponsor: University Hospital, Tours

location_facility: Service de Médecine Interne - Nutrition / CHRU de Tours


title: a Randomized Controlled Trial Evaluating the Effectiveness and the Safety of Surgical Masks Wared by the Index Patient for Preventing Secondary Transmission of Influenza A in Households

acronym: GRIPMASK

summary: This work aims to measure the effectiveness of face mask worn by a patient with flu to avoid transmission to other persons in the household.

ReferenceCitation: Sies H, Akerboom TP, Tager JM. Mitochondrial and cytosolic NADPH systems and isocitrate dehydrogenase indicator metabolites during ureogensis from ammonia in isolated rat hepatocytes. Eur J Biochem. 1977 Jan;72(2):301-7.

ReferenceCitation: Canini L, Andréoletti L, Ferrari P, D'Angelo R, Blanchon T, Lemaitre M, Filleul L, Ferry JP, Desmaizieres M, Smadja S, Valleron AJ, Carrat F. Surgical mask to prevent influenza transmission in households: a cluster randomized trial. PLoS One. 2010 Nov 17;5(11):e13998. doi: 10.1371/journal.pone.0013998.

family: Canini

full_name: Laetitia Canini

given: Laetitia

family: Andréoletti

full_name: Laurent Andréoletti

given: Laurent

family: Ferrari

full_name: Pascal Ferrari

given: Pascal

family: D'Angelo

full_name: Romina D'Angelo

given: Romina

family: Blanchon

full_name: Thierry Blanchon

given: Thierry

family: Lemaitre

full_name: Magali Lemaitre

given: Magali

family: Filleul

full_name: Laurent Filleul

family: Ferry

full_name: Jean-Pierre Ferry

given: Jean-Pierre

family: Desmaizieres

full_name: Michel Desmaizieres

given: Michel

family: Smadja

full_name: Serge Smadja

given: Serge

family: Valleron

full_name: Alain-Jacques Valleron

given: Alain-Jacques

family: Carrat

full_name: Fabrice Carrat

given: Fabrice

currency_apc_doaj: USD

journal_name: PLoS ONE

evidence: oa repository (semantic scholar lookup)

version: submittedVersion

publisher: Public Library of Science (PLoS)

publisher_dissemination: Public Library of Science

publisher_group: Public Library of Science

publisher_normalized: Public Library of Science

title: Surgical Mask to Prevent Influenza Transmission in Households: A Cluster Randomized Trial


title: Ancillary Study of the Registry Karolinska-Rennes (KaRen) : Prospective Study of Dyssynchrony in Heart Failure With Preserved Ejection Fraction

acronym: KaRen

summary:
Background:

Heart failure with preserved ejection fraction (HFPEF) is common but not well understood. Electrical dyssynchrony in systolic heart failure is harmful. Little is known about the prevalence and the prognostic impact of dyssynchrony in HFPEF.

Methods:

We have designed a prospective, multicentre, international, observational study to characterize HFPEF and to determine whether electrical or mechanical dyssynchrony affects prognosis. Patients presenting with acute heart failure will be screened.

Inclusion criteria will be:

acute presentation with Framingham criteria for heart failure, left ventricular EF ≥45%, BNP >100 ng/L or NT-proBNP >300 ng/L. Patients will return in stable condition 4-8 weeks after the index presentation and undergo questionnaires, serology, ECG and Dopplerechocardiography. Thereafter, patients will be followed for mortality and heart failure hospitalization every 6 months for at least 18 months. Sub-studies will focus on echocardiographic changes from the acute presentation to the stable condition and on exercise echocardiography.

Conclusion:

KaRen aims to characterize electrical and mechanical dyssynchrony and to assess its prognostic impact in the HFPEF. The ancillary study of the exercise stress echocardiography sought to improve our understanding of HFPEF and generate answers to the question whether dyssynchrony could be a target for therapy in HFPEF.

ReferenceCitation: Hage C, Wärdell E, Linde C, Donal E, Lam CSP, Daubert C, Lund LH, Månsson-Broberg A. Circulating neuregulin1-β in heart failure with preserved and reduced left ventricular ejection fraction. ESC Heart Fail. 2020 Apr;7(2):445-455. doi: 10.1002/ehf2.12615. Epub 2020 Jan 24.

name: Department of Medicine Karolinska Institutet – Solna  Stockholm Sweden

name: Heart and Vascular Theme Karolinska University Hospital  SE‐171 76 Stockholm Sweden

family: Hage

full_name: Camilla Hage

given: Camilla

name: Department of Medicine Karolinska Institutet – Huddinge  Huddinge Sweden

family: Wärdell

full_name: Eva Wärdell

given: Eva

family: Linde

full_name: Cecilia Linde

given: Cecilia

name: Département de Cardiologie & CIC‐IT U 804 Centre Hospitalier Universitaire de Rennes  Rennes France

family: Donal

full_name: Erwan Donal

given: Erwan

name: National Heart Centre Singapore Duke‐National University of Singapore  Singapore Singapore

name: University Medical Centre Groningen  Groningen The Netherlands

name: The George Institute for Global Health  Sydney Australia

family: Lam

full_name: Carolyn S.P. Lam

given: Carolyn S.P.

family: Daubert

full_name: Claude Daubert

given: Claude

family: Lund

full_name: Lars H. Lund

given: Lars H.

family: Månsson‐Broberg

full_name: Agneta Månsson‐Broberg

given: Agneta

journal_name: ESC Heart Failure

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - ParisTech

repository_normalized: HAL

repository_institution: University of Groningen / Centre for Information Technology - University of Groningen research database

repositories:
HAL
PubMed Central
pure.rug.nl

title: Circulating neuregulin1‐β in heart failure with preserved and reduced left ventricular ejection fraction

ReferenceCitation: Hage C, Bjerre M, Frystyk J, Gu HF, Brismar K, Donal E, Daubert JC, Linde C, Lund LH. Comparison of Prognostic Usefulness of Serum Insulin-Like Growth Factor-Binding Protein 7 in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction. Am J Cardiol. 2018 Jun 15;121(12):1558-1566. doi: 10.1016/j.amjcard.2018.02.041. Epub 2018 Mar 14.

family: Bjerre

full_name: Mette Bjerre

given: Mette

family: Frystyk

full_name: Jan Frystyk

given: Jan

family: Gu

full_name: Harvest F. Gu

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

ReferenceCitation: Nagy AI, Hage C, Merkely B, Donal E, Daubert JC, Linde C, Lund LH, Manouras A. Left atrial rather than left ventricular impaired mechanics are associated with the pro-fibrotic ST2 marker and outcomes in heart failure with preserved ejection fraction. J Intern Med. 2018 Apr;283(4):380-391. doi: 10.1111/joim.12723. Epub 2018 Feb 12.

name: Heart and Vascular Center; Semmelweis University; Budapest Hungary

name: Theme of Heart and Vessels; Karolinska University Hospital; Stockholm Sweden

name: Institution for Medicine; Karolinska Institutet; Stockholm Sweden

name: Département de Cardiologie & CIC-IT U 804; Centre Hospitalier Universitaire de Rennes; Rennes France

repository_institution: Library of the Hungarian Academy of Sciences - Repository of the Academy's Library

repository_institution: Semmelweis University - Semmelweis University Repository

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Archive ouverte HAL

ReferenceCitation: Donal E, Lund LH, Oger E, Bosseau C, Reynaud A, Hage C, Drouet E, Daubert JC, Linde C; KaRen Investigators. Importance of combined left atrial size and estimated pulmonary pressure for clinical outcome in patients presenting with heart failure with preserved ejection fraction. Eur Heart J Cardiovasc Imaging. 2017 Jun 1;18(6):629-635. doi: 10.1093/ehjci/jex005.

name: Cardiologie, CHU Rennes, 35000 RENNES, France

name: CIC-IT 1414, Université Rennes-1, 35000 Rennes, France

name: Department of Medicine, Karolinska Institutet and Department of Cardiology, Karolinska University Hospital, 171 77 Stockholm, Sweden

name: Pharmacologie Clinique et CIC-IP 1414, CHU Rennes et Université Rennes-1

name: Cellule Registres, Société Française de Cardiologie et URC Paris Est., 75012 Paris, France

journal_name: European Heart Journal - Cardiovascular Imaging

ReferenceCitation: Hage C, Michaëlsson E, Linde C, Donal E, Daubert JC, Gan LM, Lund LH. Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction: A Holistic Proteomic Approach. Circ Cardiovasc Genet. 2017 Feb;10(1). pii: e001633. doi: 10.1161/CIRCGENETICS.116.001633.

name: From the Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (C.H., C.L., L.H.L.); Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (C.H., C.L., L.H.L.); Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Mölndal, Sweden (E.M., L.-M.G.); Département de Cardiologie and CIC-IT U 804, Centre Hospitalier Universitaire de Rennes, France (E.D., J.-C.D.); and Department of Molecular and Clinical...

ReferenceCitation: Bosseau C, Donal E, Lund LH, Oger E, Hage C, Mulak G, Daubert JC, Linde C; KaRen investigators. The prognostic significance of atrial fibrillation in heart failure with preserved ejection function: insights from KaRen, a prospective and multicenter study. Heart Vessels. 2017 Jun;32(6):735-749. doi: 10.1007/s00380-016-0933-8. Epub 2016 Dec 27.

ReferenceCitation: Hage C, Lund LH, Donal E, Daubert JC, Linde C, Mellbin L. Copeptin in patients with heart failure and preserved ejection fraction: a report from the prospective KaRen-study. Open Heart. 2015 Nov 3;2(1):e000260. doi: 10.1136/openhrt-2015-000260. eCollection 2015.

ReferenceCitation: Donal E, Lund LH, Oger E, Hage C, Persson H, Reynaud A, Ennezat PV, Bauer F, Sportouch-Dukhan C, Drouet E, Daubert JC, Linde C; KaRen Investigators. Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study. Arch Cardiovasc Dis. 2014 Feb;107(2):112-21. doi: 10.1016/j.acvd.2013.11.002. Epub 2013 Dec 30.

location_facility: Service de Cardiologie et CIT-IC 804, LTSI INSERM U 642


title: Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit

acronym: IHPOTOTAM

summary:
Bacterial meningitis is a severe infection of the envelope which surrounds the brain. It is sometimes responsible for a cerebral oedema mattering with a loss of consciousness (coma). The usual treatment of this affection is based on the antibiotic therapy, anti-inflammatory drug and resuscitation measures in intensive care setting but the prognosis of comatose patients remains poor.

Moderate hypothermia (body temperature is downed between 32 and 34°C°) made the proof of its efficiency in certain cerebral pathologies (notably the cerebral distress after cardiac arrest or oxygen lack in neonates) but was never evaluated in meningitis. In meningitis animal studies and in severe traumatic brain injury, moderate hypothermia is able to diminish cerebral oedema and brain inflammation.

Thus, the objective of this study is to compare two strategies: only usual care or usual care completed by moderate hypothermia. The body temperature will be lowered between 32 and 34°C by means of a catheter placed in a big vein and connected to a machine in which circulates a cold liquid, or by means of an external cooling (ice-cold blanket, ice packs placed on the body). Whatever technique is chosen, the technique is perfectly mastered by the teams which take charge of the patients. After 48 hours, the technique of hypothermia will be suspended and body temperature will return passively and gradually to normal.

The investigators believe that moderate hypothermia will improve the prognosis of the most severe patients.

ReferenceCitation: Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farèse M, Le Tulzo Y, Wolff M. Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA. 2013 Nov 27;310(20):2174-83. doi: 10.1001/jama.2013.280506.

family: Mourvillier

full_name: Bruno Mourvillier

given: Bruno

family: Tubach

full_name: Florence Tubach

given: Florence

family: van de Beek

full_name: Diederik van de Beek

given: Diederik

family: Garot

full_name: Denis Garot

given: Denis

family: Pichon

full_name: Nicolas Pichon

given: Nicolas

family: Georges

full_name: Hugues Georges

given: Hugues

family: Lefevre

full_name: Laurent Martin Lefevre

given: Laurent Martin

family: Bollaert

full_name: Pierre-Edouard Bollaert

given: Pierre-Edouard

family: Boulain

full_name: Thierry Boulain

given: Thierry

family: Luis

full_name: David Luis

given: David

family: Cariou

full_name: Alain Cariou

given: Alain

family: Girardie

full_name: Patrick Girardie

given: Patrick

family: Chelha

full_name: Riad Chelha

given: Riad

family: Megarbane

full_name: Bruno Megarbane

family: Delahaye

full_name: Arnaud Delahaye

given: Arnaud

family: Chalumeau-Lemoine

full_name: Ludivine Chalumeau-Lemoine

given: Ludivine

family: Legriel

full_name: Stéphane Legriel

given: Stéphane

family: Beuret

full_name: Pascal Beuret

given: Pascal

family: Brivet

full_name: François Brivet

given: François

family: Bruel

full_name: Cédric Bruel

given: Cédric

family: Camou

full_name: Fabrice Camou

family: Chatellier

full_name: Delphine Chatellier

given: Delphine

family: Chillet

full_name: Patrick Chillet

title: Induced Hypothermia in Severe Bacterial Meningitis


title: Multicentric, Randomized, Double-blind Study Versus Placebo, With Two Parallel Groups Treated to Evaluate the Efficacy and the Tolerance of Riluzole in Children and Young Adults (6 to 20 Years of Age) With SMA. (Type II and Type III)

acronym: ASIRI

summary: This is a multicentric, randomized, double-blind study versus placebo, with two parallel groups treated to evaluate the efficacy and the tolerance of Riluzole in children and young adults (6 to 20 years of age) with SMA. (Type II and Type III).


title: A Randomized Trial Comparing Recell® Autologous Epidermal Cells Harvesting Kits Versus Classic Skin Grafts for the Treatment of Acute Burn in Adults and Children

acronym: ENSEM

summary: The aim of the study is to compare results obtained with epidermal cell spray and classic skin grafting for epidermal replacement in acute burns