title: Prospective Cohort of Patients Hospitalized in West French Intensive Care Units.

acronym: ATLANREA

summary: The purpose of this observational epidemiological study is to investigate the management and the complications associated with Non Traumatic Neuro-Vascular Diseases. Data will be analysed to answer pre-defined scientific projects and to improve management of these conditions.

location_facility:
Rennes University Hospital
CHU de Brest La Cavale Blanche
Tours University Hospital
Angers University Hospital
Poitiers University Hospital
Nantes University Hospital


title: Validation d'un Algorithme Diagnostique de l'artérite Temporale Giganto-cellulaire basé Sur l'échographie-doppler Couleur Des artères Temporales Superficielles et Des Axes Cervico-encéphaliques

acronym: ECHORTON

summary: Giant cell arteritis (GCA or temporal arteritis or cranial arteritis) or Horton disease is a vasculitis that occurs in older adults, affecting vessels of medium and large caliber. The diagnosis of GCA is a challenge for general practitioners and specialists. Since 1970, it is based on a combination of clinical, biological and histological signs. Temporal artery biopsy (TAB) was the reference method until recently. However, TAB has many drawbacks. Therefore, researches of the past 20 years have been intended to develop alternative diagnostic methods. This was notably the case of the color Doppler ultrasound (CDU) since the description by Wolfgang Schmidt of the halo sign. Although European and British recommendations put CDU as second line method, many authors suggest the possibility to do without TAB in many cases. In addition, many practitioners believe that it is not "ethical" to use an invasive unprofitable procedure like TAB, and have already been using CDU in their routine practice. However, no diagnostic algorithm validating this approach in a prospective series has been published to date. Therefore, the present study aim at validating a diagnostic algorithm of giant cell arteritis using color Doppler imaging of temporal arteries and cervicocephalic axes as first screening method.

study_start_date_type: Actual

status: Active, not recruiting

study_completion_date_type: Anticipated

study_type: Interventional

primary_purpose: Diagnostic

enrollment_type: Actual

ReferenceType: background

ReferenceCitation: Weyand CM, Goronzy JJ. Giant-cell arteritis and polymyalgia rheumatica. N Engl J Med. 2014 Oct 23;371(17):1653. doi: 10.1056/NEJMc1409206.

ReferenceCitation: Smith JH, Swanson JW. Giant cell arteritis. Headache. 2014 Sep;54(8):1273-89. doi: 10.1111/head.12425. Epub 2014 Jul 18. Review.

ReferenceCitation: Petri H, Nevitt A, Sarsour K, Napalkov P, Collinson N. Incidence of giant cell arteritis and characteristics of patients: data-driven analysis of comorbidities. Arthritis Care Res (Hoboken). 2015 Mar;67(3):390-5. doi: 10.1002/acr.22429.

ReferenceCitation: Calvo-Romero JM. Giant cell arteritis. Postgrad Med J. 2003 Sep;79(935):511-5. Review.

ReferenceCitation: Roblot P. [When should Horton's disease be suspected?]. Rev Prat. 1999 Mar 15;49(6):593-7. French.

ReferenceCitation: Baslund B, Helleberg M, Faurschou M, Obel N. Mortality in patients with giant cell arteritis. Rheumatology (Oxford). 2015 Jan;54(1):139-43. doi: 10.1093/rheumatology/keu303. Epub 2014 Aug 13.

ReferenceCitation: Nuenninghoff DM, Hunder GG, Christianson TJ, McClelland RL, Matteson EL. Mortality of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years. Arthritis Rheum. 2003 Dec;48(12):3532-7.

ReferenceCitation: Kermani TA, Warrington KJ, Crowson CS, Ytterberg SR, Hunder GG, Gabriel SE, Matteson EL. Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis. Ann Rheum Dis. 2013 Dec;72(12):1989-94. doi: 10.1136/annrheumdis-2012-202408. Epub 2012 Dec 19.

ReferenceCitation: Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum. 1990 Aug;33(8):1122-8.

ReferenceCitation: Hunder GG. The early history of giant cell arteritis and polymyalgia rheumatica: first descriptions to 1970. Mayo Clin Proc. 2006 Aug;81(8):1071-83.

ipd_sharing: Undecided

lead_sponsor: Poitiers University Hospital

location_facility: Groupe Hospitalier de la Rochelle Ré Aunis

location_facility: Centre Hospitalier Universitaire de Nantes

location_facility: Centre Hospitalier Universitaire de Poitiers

intervention_type: Other

lead_sponsor_type: academique

status_simplified: Ongoing


title: Evaluation of a Marine OXYgen Carrier: HEMO2Life® for hypOthermic Kidney Graft Preservation, Before Transplantation

summary:
Kidney transplantation is the treatment of choice for end stage renal diseases, increasing life expectancy and quality of life. Improvement in organ preservation is a critical issue in this context.

This is a safety study evaluating the use of an oxygen carrier HEMO2Life® as an additive in organ preservation solution in kidney transplantation.

status: Completed

study_completion_date_type: Actual

primary_purpose: Other

lead_sponsor: University Hospital, Brest

location_facility:
Hôpital Edouard Herriot
CHRU Brest
CHU Limoges
CHU Poitiers
CHRU de Tours
Hôpital la Pitié Salpetrière

intervention_type: Procedure

status_simplified: Completed


title: Impact of a Pluriprofessional Intervention to Improve Medication Adherence (Secondary Preventive Medication) in Patients After Ischemic Stroke (ADMED-AVC)

acronym: ADMED-AVC

summary:
Medication adherence is a major factor to prevent vascular recurrence after a first ischemic stroke. Nevertheless, it is suboptimal and the implementation of specific interventions are needed to improve it.

A patient - centered and pluriprofessional structured intervention, targeting the medication, introduced at hospital discharge and continued at home (by regular telephone contact) could improve medication adherence one year after stroke.

This intervention would consist of semi structured interviews patient-pharmacist at different times during one year after stroke. The information about the therapeutic management of the patient will be shared between healthcare professionals : general practitioners (GP) and community pharmacists (CP), hospital clinical pharmacist (HCP) and physician (HPhys).

It will allow for decrease of the recurrent stroke and others cardiovascular complications based on a better adherence to preventive medication. Furthermore the decrease of the iatrogenic events and the improvement of the quality of life of patients may be also associated.

status: Unknown status

design_allocation: Randomized

primary_purpose: Supportive Care

enrollment_type: Anticipated

ReferenceType: derived

ReferenceCitation: Khettar S, Jacquin Courtois S, Luaute J, Decullier E, Bin S, Dupuis M, Derex L, Mechtouff L, Nighoghossian N, Dussart C, Rode G, Janoly-Dumenil A. Multiprofessional intervention to improve adherence to medication in stroke patients: a study protocol for a randomised controlled trial (ADMED AVC study). Eur J Hosp Pharm. 2020 Sep 25. pii: ejhpharm-2020-002425. doi: 10.1136/ejhpharm-2020-002425. [Epub ahead of print]

family: Khettar

full_name: Sophie Khettar

given: Sophie

sequence: first

family: Jacquin Courtois

full_name: Sophie Jacquin Courtois

sequence: additional

family: Luaute

full_name: Jacques Luaute

given: Jacques

family: Decullier

full_name: Evelyne Decullier

given: Evelyne

family: Bin

full_name: Sylvie Bin

given: Sylvie

family: Dupuis

full_name: Marine Dupuis

given: Marine

family: Derex

full_name: Laurent Derex

given: Laurent

family: Mechtouff

full_name: Laura Mechtouff

given: Laura

family: Nighoghossian

full_name: Norbert Nighoghossian

given: Norbert

family: Dussart

full_name: Claude Dussart

given: Claude

family: Rode

full_name: Gilles Rode

given: Gilles

family: Janoly-Dumenil

full_name: Audrey Janoly-Dumenil

given: Audrey

bso_classification: Medical research

datasource: user

genre: journal-article

genre_raw: journal-article

journal_name: European Journal of Hospital Pharmacy

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via page says license)

host_type: publisher

license: cc-by-nc

license_normalized: cc-by-nc

version: publishedVersion

evidence: oa repository (via OAI-PMH doi match)

host_type: repository

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - memSIC

repository_normalized: HAL

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inserm

publisher: BMJ

publisher_dissemination: British Medical Journal

publisher_group: British Medical Journal

publisher_normalized: British Medical Journal

lead_sponsor: Hospices Civils de Lyon

location_facility: Service de médecine physique et de réadaptation, Hôpital Henry Gabrielle, Groupement Hospitalier Sud, HCL

location_facility: Service de neurologie vasculaire, Hôpital P Wertheimer, HCL

location_facility: Service de médecine physique et de réadaptation, Groupe hospitalier Lariboisière - Fernand Vidal, AP-HP

location_facility: Service de médecine physique et de réadaptation, Hôpital sud, CHU de Grenoble

location_facility: Service de médecine physique et de réadaptation, Hôpital Bellevue, CHU Saint Etienne

location_facility: Service de médecine physique et de réadaptation, Hôpital Nord, CHU de Clermont Ferrand

intervention_type: Behavioral

status_simplified: Unknown


type: Other Identifier

title: Impact of the Implementation of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older

acronym: MEDREV

summary:
The primary objective of this study is to evaluate the impact of the implementation of collaborative pharmaceutical care on drug support at admission for patients 65 years of age and older.

This is a cluster-randomized study with a stepped-wedge design. Clusters correspond to participating centers. A randomly selected center is crossed-over into the intervention every fifteen days after the start of inclusions.

primary_purpose: Prevention

ReferenceCitation: Leguelinel-Blache G, Castelli C, Roux-Marson C, Bouvet S, Andrieu S, Cestac P, Collomp R, Landais P, Loulière B, Mouchoux C, Varin R, Allenet B; MEDREV Working Group, Bedouch P, Kinowski JM. Impact of collaborative pharmaceutical care on in-patients' medication safety: study protocol for a stepped wedge cluster randomized trial (MEDREV study). Trials. 2018 Jan 8;19(1):19. doi: 10.1186/s13063-017-2412-7.

family: Leguelinel-Blache

full_name: Géraldine Leguelinel-Blache

given: Géraldine

family: Castelli

full_name: Christel Castelli

given: Christel

family: Roux-Marson

full_name: Clarisse Roux-Marson

given: Clarisse

family: Bouvet

full_name: Sophie Bouvet

family: Andrieu

full_name: Sandrine Andrieu

given: Sandrine

family: Cestac

full_name: Philippe Cestac

given: Philippe

family: Collomp

full_name: Rémy Collomp

given: Rémy

family: Landais

full_name: Paul Landais

given: Paul

family: Loulière

full_name: Bertrice Loulière

given: Bertrice

family: Mouchoux

full_name: Christelle Mouchoux

given: Christelle

family: Varin

full_name: Rémi Varin

given: Rémi

family: Allenet

full_name: Benoit Allenet

given: Benoit

family: Bedouch

full_name: Pierrick Bedouch

given: Pierrick

family: Kinowski

full_name: Jean-Marie Kinowski

given: Jean-Marie

currency_apc_doaj: GBP

journal_name: Trials

oa_colors: green gold

evidence: oa journal (via doaj)

license: cc-by

license_normalized: cc-by

repository_institution: PubMed Central - Europe PMC

repository_normalized: PubMed Central

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Ecole polytechnique

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - ParisTech

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

title: Impact of collaborative pharmaceutical care on in-patients’ medication safety: study protocol for a stepped wedge cluster randomized trial (MEDREV study)

lead_sponsor: Centre Hospitalier Universitaire de Nīmes

location_facility: CHRU de Toulouse - Hôpital Paule de Viguier

location_facility: CHRU de Nîmes - Hôpital Universitaire Carémeau

location_facility: CHU de Grenoble - Hôpital Albert Michallon

location_facility: CHRU de Strasbourg - Hôpital de Hautepierre


title: Prevalence, Characteristics and Risk Factors of HIV-Associated Neurocognitive Disorders in Subjects Between the Ages of 55 and 70 Years: An Exposed/Unexposed Cross Sectional Study

summary: The primary objective is to measure the prevalence of according to the Frascati classification in a HIV-infected population aged between 55 and 70 years (exposed group) and to compare it with the prevalence of HIV-Associated Neurocognitive Disorders (HAND) in unexposed subjects from the general population-based cohort CONSTANCES, matching subjects on age, gender, geographical origin and socioprofessional category.

ReferenceCitation: Makinson A, Dubois J, Eymard-Duvernay S, Leclercq P, Zaegel-Faucher O, Bernard L, Vassallo M, Barbuat C, Gény C, Thouvenot E, Costagliola D, Ozguler A, Zins M, Simony M, Reynes J, Berr C. Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study. Clin Infect Dis. 2020 Jun 10;70(12):2641-2648. doi: 10.1093/cid/ciz670.

name: Infectious and Tropical Diseases Department, University Hospital Montpellier, and Fédération d’Infectiologie Multidisciplinaire de l’Arc Alpin, Université Grenoble Alpes, Marseille

name: Institut de Recherche et Développement, and Fédération d’Infectiologie Multidisciplinaire de l’Arc Alpin, Université Grenoble Alpes;, Institut National de la Santé et de la Recherche Médicale (French Institute of Health and Medical Research) (INSERM), University of Montpellier TransVIHMI Unit, Marseille

family: Makinson

full_name: Alain Makinson

given: Alain

name: INSERM, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, and Fédération d’Infectiologie Multidisciplinaire de l’Arc Alpin, Université Grenoble Alpes, Marseille

family: Dubois

full_name: Jonathan Dubois

given: Jonathan

family: Eymard-Duvernay

full_name: Sabrina Eymard-Duvernay

given: Sabrina

name: Infectious Disease Unit, University Hospital of Grenobles Alpes, and Fédération d’Infectiologie Multidisciplinaire de l’Arc Alpin, Université Grenoble Alpes, Marseille

family: Leclercq

full_name: Pascale Leclercq

given: Pascale

name: Clinical Immuno-Hematology Department, Aix-Marseille University, Sainte-Marguerite University Hospital, Marseille

family: Zaegel-Faucher

full_name: Olivia Zaegel-Faucher

given: Olivia

name: Infectious Diseases Unit, University Hospital Tours, Nîmes

family: Bernard

full_name: Louis Bernard

given: Louis

name: Department of Internal Medicine, Cannes General Hospital, Nîmes

family: Vassallo

full_name: Matteo Vassallo

given: Matteo

name: Infectious Diseases Department, University Hospital, Nîmes

family: Barbuat

full_name: Claudine Barbuat

given: Claudine

name: Neurology Department, Montpellier University Hospital Center, Gui de Chauliac Hospital, Nîmes

family: Gény

full_name: Christian Gény

given: Christian

name: Neurology Department, University Hospital, Nîmes

family: Thouvenot

full_name: Eric Thouvenot

given: Eric

name: Sorbonne University, INSERM, Institut Pierre Louis d’Épidémiologie et de Santé Publique (IPLESP), Paris, France

family: Costagliola

full_name: Dominique Costagliola

given: Dominique

name: INSERM, Paris Descartes University Population-based Epidemiological Cohorts Unit, Villejuif, France

family: Ozguler

full_name: Anna Ozguler

given: Anna

family: Zins

full_name: Marie Zins

given: Marie

name: ANRS (France Recherche Nord & Sud Sida-HIV Hépatites), Unit for Basic and Clinical Research on Viral Hepatitis and HIV, Paris, France

family: Simony

full_name: Mélanie Simony

given: Mélanie

family: Reynes

full_name: Jacques Reynes

given: Jacques

family: Berr

full_name: Claudine Berr

journal_name: Clinical Infectious Diseases

publisher: Oxford University Press (OUP)

publisher_dissemination: Oxford University Press

publisher_group: Oxford University Press

publisher_normalized: Oxford University Press

title: Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55–70 Study

lead_sponsor: ANRS, Emerging Infectious Diseases

location_facility: Hôpital Gui de Chauliac - Service des Maladies Infectieuses

location_facility: Hôpital Carémeau - Service des Maladies Infectieuses

location_facility: Hôpital Bretonneau - Service des Maladies Infectieuses

location_facility: Hôpital Michallon- Service des Maladies Infectieuses

location_facility: Centre Hospitalier de Cannes - Service de Médecine Interne Oncologie

location_facility: Hôpial Sainte Marguerite - Service d'hématologie-Cisih


title: Addition of Neuromuscular-Blocking Agents During Sevoflurane Induction in Infants : Potential Interest in Reducing Hypoxemia Episodes

acronym: ROC-HYPOX

summary:
The prevention of the occurrence of respiratory events is a constant concern in pediatric anesthesia, as these represent the main cause of the anesthesic mortality. These events occur partly during induction of anesthesia and are all the more frequent as the child is young.

The French recommendations do not propose the use of neuromuscular-blocking agents in pediatric anesthesia. This recommendation is controversial In a recently published study, it has been shown that the use of neuromuscular blocking agents during induction in children under 2 years improves intubating conditions and reduces the incidence of hemodynamic and respiratory events. This monocentric study, centered on intubating conditions, does not allow to conclude on the influence of muscle relaxants on reduction of the respiratory morbidity.

The objective of study is to demonstrate that, in children under 2 years, changing the anesthesia protocol can reduce the incidence and severity of episodes of hypoxemia associated with respiratory events occurring during induction

status: Recruiting

lead_sponsor: Fondation Ophtalmologique Adolphe de Rothschild

location_facility: Centre Hospitalier Intercommunal Creteil (CHIC)

location_facility: Hôpital Jeanne de Flandre, CHRU de Lille

location_facility: Fondation ophtalmique Adolphe de Rothschild

lead_sponsor_type: industriel


title: Multicentre Study Evaluating the Use of a Biodegradable Balloon for the Treatment of Prostate Cancer (of Intermediate Risk) by Intensity Modulated Conformal Radiotherapy (BioPro-RCMI)

acronym: BioPro-RCMI

summary:
The benefit of dose escalation in radiotherapy (RT) for biochemical control of prostate cancer is a clearly established fact based on the results of different published prospective trials. This benefit, acquired with three-dimensional conformal radiation technique is counterbalanced by an increase in urinary and gastrointestinal toxicity. The joint progress of dose planning systems and multileaf collimators (MLC) technology have enabled the Intensity Modulated Radiation Therapy (IMRT). Recently the contribution of "spacers" positioned in the septum between the rectum and the prostate could improve the functional results of IMRT in terms of rectal toxicity.

The aim of the investigators study is to assess the dosimetric gain from the contribution of the implantable BioProtect balloon on organs at risk.

status: Suspended

primary_purpose: Treatment

ReferenceCitation: Pasquier D, Bogart E, Bonodeau F, Lacornerie T, Lartigau E, Latorzeff I. BioPro-RCMI-1505 trial: multicenter study evaluating the use of a biodegradable balloon for the treatment of intermediate risk prostate cancer by intensity modulated radiotherapy; study protocol. BMC Cancer. 2018 May 16;18(1):566. doi: 10.1186/s12885-018-4492-5.

family: Pasquier

full_name: David Pasquier

given: David

family: Bogart

full_name: Emilie Bogart

given: Emilie

family: Bonodeau

full_name: François Bonodeau

given: François

family: Lacornerie

full_name: Thomas Lacornerie

given: Thomas

family: Lartigau

full_name: Eric Lartigau

family: Latorzeff

full_name: Igor Latorzeff

given: Igor

journal_name: BMC Cancer

evidence: oa repository (via pmcid lookup)

license_normalized: no license

publisher: Springer Science and Business Media LLC

publisher_dissemination: Springer-Nature

publisher_group: Springer-Nature

publisher_normalized: Springer

ipd_sharing: No

lead_sponsor: Centre Oscar Lambret

location_facility:
Centre Oscar Lambret
Centre de Cancérologie Paris Nord
Clinique Pasteur
Institut Bergonié
Centre Léonard de Vinci
Clinique Hartmann

intervention_type: Device


title: Randomized Controlled Study of Low-FODMAP Diet in Patients With GERD Refractory to Protons Pump Inhibitors

acronym: EFFORR

summary: The aim of this study is to determine the effects of a low Fermentescible Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAP) diet in patients with documented refractory GERD on proton pump inhibitor (PPI) therapy.

lead_sponsor: University Hospital, Bordeaux

location_facility: Hépato-Gastroentérologie et oncologie digestive,

intervention_type: Dietary Supplement


title: Effect of Intramyocardial Mesenchymal Stem Cells Injection in Patients With Chronic Ischemic Cardiomyopathy and Left Ventricular Dysfunction Guide by NogaStar XP System Catheter.

summary: Stem cell therapy is an emerging treatment for cardiovascular disease but the best cell type and delivery method remain to be determined. Pre-clinical studies demonstrated improvement of cardiac function by Mesenchymal stem cells (MSC) therapy in particular by their paracrine and immunosuppressive properties. Investigators initiated the MESAMI program by the bicentric pilot phase and highlighted the safety and feasibility of intramyocardial injections of MSCs from bone marrow in patients with chronic ischemic cardiomyopathy and left ventricular dysfunction, guide by the NOGA-XP system. The MESAMI program continues with the phase 2, multicenter, double-blind, randomized, placebo-controlled trial.The aim of this phase 2 study is to demonstrate a functional improvement, measuring peak VO2, at 3 months between the cell therapy group and the placebo group.

lead_sponsor: University Hospital, Toulouse

location_facility: University hospital of Pitié-Salpêtrière

location_facility: Cardiology Department of Rangueil Hospital - Rangueil Hospital

intervention_type: Drug


title: MIRs03: A Double-blind Randomized Trial of Paravertebral Block With Ropivacaine Before Breast Cancer Surgery: Effects on Chronic Postoperative Pain

summary: Compare the effect of paravertebral block (PVB) with Ropivacaine or placebo on the incidence of chronic pain 3 months after breast cancer surgery.

ReferenceType: result

ReferenceCitation: Cohen SP, Raja SN. Prevention of chronic postsurgical pain: the ongoing search for the holy grail of anesthesiology. Anesthesiology. 2013 Feb;118(2):241-3. doi: 10.1097/ALN.0b013e31827d4129.

name: Uniformed Services University AND Johns Hopkins School of Medicine, Dept. of Anesthesiology and Critical Care Medicine

family: Cohen

full_name: Steven P. Cohen

given: Steven P.

name: Department of Anesthesiology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland.

family: Raja

full_name: Srinivasa N. Raja

given: Srinivasa N.

journal_name: Anesthesiology

publisher: Ovid Technologies (Wolters Kluwer Health)

publisher_dissemination: Wolters Kluwer Health

publisher_group: Wolters Kluwer Health

publisher_normalized: Wolters Kluwer Health

title: Prevention of Chronic Postsurgical Pain

ReferenceCitation: Albi-Feldzer A, Mouret-Fourme E E, Hamouda S, Motamed C, Dubois PY, Jouanneau L, Jayr C. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain. Anesthesiology. 2013 Feb;118(2):318-26. doi: 10.1097/ALN.0b013e31827d88d8.

name: Professional Staff, Department of Anesthesia and Intensive Care, Institut Godinot, Reims, France.

family: Albi-Feldzer

full_name: Aline Albi-Feldzer

given: Aline

name: Professional Staff, Department of Anesthesia and Intensive Care, Institut Gustave Roussy, Villejuif, France.

family: Mouret-Fourme E

full_name: Emmanuelle Mouret-Fourme E

given: Emmanuelle

name: Professional Staff, Department of Anesthesia and Intensive Care, Institut Curie-Hôpital René Huguenin, Saint-Cloud, France.

family: Hamouda

full_name: Smail Hamouda

given: Smail

name: Professional Staff, Clinical Epidemiology, Institut Curie-Hôpital René Huguenin.

family: Motamed

full_name: Cyrus Motamed

given: Cyrus

name: Professional Staff, Department of Anesthesia and Intensive Care, Paoli Calmette, Marseille, France.

family: Dubois

full_name: Pierre-Yves Dubois

given: Pierre-Yves

family: Jouanneau

full_name: Ludivine Jouanneau

given: Ludivine

family: Jayr

full_name: Christian Jayr

title: A Double-blind Randomized Trial of Wound and Intercostal Space Infiltration with Ropivacaine during Breast Cancer Surgery

ReferenceCitation: Gärtner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009 Nov 11;302(18):1985-92. doi: 10.1001/jama.2009.1568. Erratum in: JAMA. 2012 Nov 21;308(19):1973.

family: Gärtner

full_name: Rune Gärtner

given: Rune

family: Jensen

full_name: Maj-Britt Jensen

given: Maj-Britt

family: Nielsen

full_name: Jeanette Nielsen

given: Jeanette

family: Ewertz

full_name: Marianne Ewertz

given: Marianne

family: Kroman

full_name: Niels Kroman

given: Niels

family: Kehlet

full_name: Henrik Kehlet

given: Henrik

journal_name: JAMA

oa_host_type: publisher

evidence: open (via free pdf)

publisher: American Medical Association (AMA)

publisher_dissemination: American Medical Association

publisher_group: American Medical Association

publisher_normalized: American Medical Association

title: Prevalence of and Factors Associated With Persistent Pain Following Breast Cancer Surgery

ReferenceCitation: Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006 May 13;367(9522):1618-25. Review.

ReferenceCitation: Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology. 2000 Oct;93(4):1123-33. Review.

location_facility:
Centre Léon Bérard
Centre Jean PERRIN
Institut de Cancérologie de Lorraine
Centre Antoine LACASSAGNE
INSTITUT CURIE - Site Paris
Institut Curie site Saint-Cloud


title: Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1

summary: A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.

design_allocation: Non-Randomized

primary_purpose: Screening

ReferenceCitation: Biotteau M, Tournay E, Baudou E, Destarac S, Iannuzzi S, Faure-Marie N, Castelnau P, Schweitzer E, Rodriguez D, Kemlin I, Dorison N, Rivier F, Carneiro M, Preclaire E, Barbarot S, Lauwers-Cancès V, Chaix Y. Reading Comprehension Impairment in Children With Neurofibromatosis Type 1 (NF1): The Need of Multimodal Assessment of Attention. J Child Neurol. 2021 Jul;36(8):625-634. doi: 10.1177/0883073820981270. Epub 2021 Jan 28.

name: ToNIC, Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, France

name: Children’s Hospital, Toulouse-Purpan University Hospital, Toulouse, France

family: Biotteau

full_name: Maëlle Biotteau

given: Maëlle

name: Epidemiology Department, Toulouse University Hospital, Toulouse, France

family: Tournay

full_name: Elodie Tournay

given: Elodie

family: Baudou

full_name: Eloise Baudou

given: Eloise

name: Pediatric Clinical Research Unit, Toulouse Clinical Investigation Center, Children’s Hospital, Purpan University Hospital, Inserm U1436, Toulouse, France

family: Destarac

full_name: Sandrine Destarac

given: Sandrine

family: Iannuzzi

full_name: Stéphanie Iannuzzi

given: Stéphanie

family: Faure-Marie

full_name: Nathalie Faure-Marie

given: Nathalie

name: Pediatric Neurology, Clocheville Children’s Hospital, Tours University Hospital, Tours, France

name: UMR 1253, iBrain, University fo Tours, Inserm, Tours, France

name: School of Medicine, University of Tours Francois Rabelais, Tours, France

family: Castelnau

full_name: Pierre Castelnau

given: Pierre

family: Schweitzer

full_name: Elisabeth Schweitzer

given: Elisabeth

name: Sorbonne University, APHP.SU, Department of Neuropediatry & Reference Center for Neurogenetics Disabilities, Armand Trousseau University Hospital, Paris, France

family: Rodriguez

full_name: Diana Rodriguez

given: Diana

family: Kemlin

full_name: Isabelle Kemlin

given: Isabelle

family: Dorison

full_name: Nathalie Dorison

name: Department of Pediatric Neurology, Montpellier University Hospital, PhyMedExp, University of Montpellier, Inserm, CNRS, Montpellier, France

family: Rivier

full_name: François Rivier

given: François

name: Department of Pediatric Neurology & Reference Center for Language Disabilities, Montpellier University Hospital, France

family: Carneiro

full_name: Maryline Carneiro

given: Maryline

family: Preclaire

full_name: Elodie Preclaire

name: Departement of Dermatology, Nantes University Hospital, Nantes, France

family: Barbarot

full_name: Sebastien Barbarot

given: Sebastien

family: Lauwers-Cancès

full_name: Valérie Lauwers-Cancès

given: Valérie

family: Chaix

full_name: Yves Chaix

given: Yves

journal_name: Journal of Child Neurology

publisher: SAGE Publications

publisher_dissemination: SAGE Publications

publisher_group: SAGE Publications

publisher_normalized: SAGE Publications

location_facility: Hopital femme-mére-enfant, Hospices civils de lyon


title: Evaluation of the Antibiofilmogramme® Test During Diabetic Foot Infections

acronym: BioFilm PieDia

summary:
This is an observational study that does not change routine care.

The primary objective of this study is to investigate the role of antibiogramme-antibiofilmogramme concordance (in terms of S. aureus strains and prescribed antibiotics) in the presence/absence of S. aureus strains at the end of a first regimen of antibiotics.

study_type: Observational

time_perspective: Prospective

location_facility: CHRU de Nîmes - Hôpital Universitaire Carémeau

location_facility: CHU de Lyon - Hôpital de la Croix-Rousse

location_facility: CHU de Clermont-Ferrand - Hôpital Gabriel-Montpied

location_facility: CHU de Lyon - Centre Hospitalier Lyon Sud

intervention_type: Biological


title: Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial

acronym: IRRICO

summary:
Spina Bifida is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube, leading to serious malformations of the nervous system. Caudal neuropore malformations almost always lead to sensory-motor deficits (including complete paraplegia) with orthopedic deformations, pressure sores, and pelvic/perineal neurological dysfunctions (affecting the bladder-sphincter, anorectal, and genital sphere).

The purpose of the study is to assess the efficacy of retrograde colonic irrigation associated with usual care (medical treatments, patient education) on anorectal dysfunction (incontinence and/or constipation), compared to usual care only.

lead_sponsor: Rennes University Hospital

location_facility:
Rennes University Hospital
CHU de Nantes
CHRU de Lille
CMRRF de Kerpape
CHU de Rouen
CHRU de Nancy-Brabois


title: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the Treatment of Stage III-IV HIV-associated Hodgkin Lymphoma

summary: This phase II trial studies the side effects and the best dose of brentuximab vedotin and combination chemotherapy work in treating patients with stage III-IV human immunodeficiency virus (HIV)-associated Hodgkin lymphoma. Monoclonal antibodies, such as brentuximab vedotin, can block cancer growth by finding cancer cells and causing them to die. Drugs used in chemotherapy, such as doxorubicin hydrochloride, vinblastine sulfate, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving brentuximab vedotin together with combination chemotherapy may kill more cancer cells.

lead_sponsor: The Lymphoma Academic Research Organisation

location_facility:
CHU de Nice
Centre Hospitalier Lyon Sud
APHP - Hôpital Saint Antoine
APHP - Hôpital Antoine Béclère
Hopital St Louis
CHU de Toulouse


title: Dead Space Closure With Quilting Suture Versus Conventional Closure With Drainage in Prevention of Seroma Formation After Mastectomy for Breast Cancer : a Randomized Controlled Trial

acronym: QUISERMAS

summary: The objective of this study is to compare quilting suture of the "dead space" without drainage of the pectoral area to conventional closure with drainage to prevent post-operative seroma requiring intervention (aspiration or surgical intervention) within 21 days after mastectomy for breast cancer.

ReferenceCitation: Ouldamer L, Bonastre J, Brunet-Houdard S, Body G, Giraudeau B, Caille A. Dead space closure with quilting suture versus conventional closure with drainage for the prevention of seroma after mastectomy for breast cancer (QUISERMAS): protocol for a multicentre randomised controlled trial. BMJ Open. 2016 Apr 4;6(4):e009903. doi: 10.1136/bmjopen-2015-009903.

family: Ouldamer

full_name: Lobna Ouldamer

given: Lobna

family: Bonastre

full_name: Julia Bonastre

given: Julia

family: Brunet-Houdard

full_name: Solène Brunet-Houdard

given: Solène

family: Body

full_name: Gilles Body

given: Gilles

family: Giraudeau

full_name: Bruno Giraudeau

given: Bruno

family: Caille

full_name: Agnès Caille

given: Agnès

journal_name: BMJ Open

repository_institution: University of Oxford - Oxford Academic Notes & Queries

version: submittedVersion

title: Dead space closure with quilting suture versus conventional closure with drainage for the prevention of seroma after mastectomy for breast cancer (QUISERMAS): protocol for a multicentre randomised controlled trial: Table 1

lead_sponsor: University Hospital, Tours

location_facility:
Institut POALI-CALMETTES
Institut de Cancérologie de l'Ouest
CHU de Poitiers
CHRU de Tours
Conception Hospital
Alliance Clinic


title: AMYLO-CARTESIAN Study :Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

acronym: AMYLOCARTESIAN

summary:
Background: The prevalence of both senile cardiac amyloidosis (CA) and aortic stenosis (AS) markedly increases with age. Aortic stenosis increases left ventricular pressure overload. Cardiac deposits have been observed in AS and the amount of these deposits has been correlated to post-surgical outcome. As they are strong echocardiographic and cardiac MRI imaging similarities between CA and AS, the investigators hypothesized that the deposit observed in AS is transthyretin amyloid deposit. The investigators objective is to demonstrate that amyloid deposit is associated with poor outcomes following aortic stenosis surgical valve replacement.

Materiel and methods: 180 patients with indication for surgical aortic valve replacement will be recruited prospectively and consecutively in 5 French centers. A replicative study will be performed in one Austrian center. Echocardiography, cardiac MRI and bone scintigraphy will be performed prior to surgery. During surgery, a basal LV septum biopsy will be collected for determination and quantification of interstitial deposits using specific staining which will be performed in a blind fashion. Clinical outcomes will be recorded during the hospitalization period following the surgery and at 1 year. Alive and re-hospitalization status will be determined. Patients will be classified according to the presence or not of amyloid deposits.

Expected results and impact: This study will emphasize how pressure overload stress accelerates and magnifies amyloid deposition usually known to be related to cardiac aging process. It will develop reliable imaging tools and markers to detect cardiac amyloid deposition. Correlation between anatomopathologic analyses and the three different imaging technics will identify accurate imaging markers of CA. A risk stratification model based on amyloid deposits level for the clinical management of these patients will be created combining imaging and biological markers.

lead_sponsor: French Cardiology Society

location_facility:
Chu Rennes
Hôpital Henri Mondor
CHU Limoges
CHU de Toulouse
CHU LYON
Centre Cardiologique du Nord


title: Assessment of Diagnostic Accuracy of 18FDG-PET-CT in Patients With Suspicion of Pacing or Defibrillation Lead Infection: a Prospective Multi-center Study

acronym: ENDOTEP

summary:
With aging of the general population and broadening indications, the number of pacemaker recipients is steadily increasing. The incidence of infections of the implanted material, a dreaded major complication, is also rising. The diagnosis is evident in presence of an abscessed pocket, cutaneous breakthrough of the pulse generator or vegetations attached to the lead. On the other hand, a proportion of patients present with less specific clinical manifestations and a pacemaker recipient may be recurrently hospitalized for an infectious disorder of unknown origin despite detailed investigations. Without proof of lead infection, removal of the system without confirmation of its infection is usually proposed, despite the known morbidity and mortality associated with the extraction procedure (0.5 to 2%). Positive culture of the leads implies that the leads were involved in the infectious process. In recent years, 18FDG-PET-CT scan has made promising contributions in different areas including imaging to detect infection at different organ sites. Absence of hyperfixation of the lead, identified by 18FDG-PET/CT scan may be an accurate sign of absence of pacing system infection.

The extraction of intracardiac implanted material, when it is indicated by the current standard strategy, may result in negative bacteriological cultures in 10 to 25% of patients, even when they did not receive antibiotics before extraction.

The hypothesis of the study is that a new strategy adding 18FDG-PET-CT to the current strategy may avoid or reduce these false-positives.

Therefore it is hypothesized that the sensitivity of 18FDG-PET-CT will be high enough to avoid unnecessary extractions of uninfected leads, resulting in a high negative predictive value of the new diagnostic strategy incorporating 18FDG-PET-CT. The present study aims at providing valid estimates of diagnostic accuracy parameters of 18FDG-PET-CT, especially its sensitivity.

For this clinical study, firstly, 18FDG-PET-CT exam will be performed in patients, with suspicion of pacing or defibrillation lead infection, hospitalized in cardiology unit; secondarily, an intervention for the extraction of the intra-cardiac material, under general anesthesia, will be practiced and then a bacteriological culture for extracted material will be required.

The end of study visit is complete the last day of material extraction. The follow up will last 2 to 7 days.

location_facility:
CHU de Grenoble - Hôpital A. Michallon
CHRU de Lille - Hôpital R. Salengro
CHU de Bordeaux
Clinique Pasteur
CHU de Nancy - Hôpital de Brabois
AP-HM - Hôpital La Timone


title: Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon

acronym: RAY-GENE

summary:
Vasospasm is a transient contraction causing a decrease in caliber of a vessel and thus a decrease in vascularization in a vascular territory leading to suffering of tissue in the sector concerned. Vasospasm-related diseases have different clinical presentations such as migraine, spastic angina, hypertension related to vasospasm or primary Raynaud's phenomenon (RP). These diseases have few therapeutic methods due to poorly understood pathophysiology. For migraine and angina, the vascular exploration is problematic unlike for primary Raynaud's phenomenon (RP).

Primary Raynaud's phenomenon (RP) is a common peripheral vascular disease to cold with an estimated prevalence between 5-9 % of the general population. It is the expression of an extreme vasospasm microcirculation of the extremities linked to hypersensitivity to cold and that is clinically expressed by the occurrence of syncope stages where the fingers are anesthetized and white, followed by a stage with hyperemic restaining .

The objective of our study is to identify new metabolic pathways involved in vasospasm in order to consider new specific treatments, currently lacking.

The identification of these pathways will be made by the detection of genetic abnormalities causing vasospasm in Raynaud's phenomenon. This disease is a perfectly appropriate model to study vasospasm by its high frequency in the population, its hereditary nature and simple diagnosis. The powerful current genetic strategies will be applied to this model (exome sequencing combined to family connection analysis).

lead_sponsor: Nantes University Hospital

location_facility: CHD La Roche sur Yon - Service Angéiologie

location_facility: C.H.R. HOPITAL SUD - Service de Médecine interne

location_facility: CHU de NANTES - Service de Médecine Interne

location_facility: CHRU HOPITAL CAVALE BLANCHE - Service de Médecine vasculaire

location_facility: CHU Angers - Service d'Explorations vasculaires

intervention_type: Genetic


title: Prospective, Randomized, Controlled and Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery

acronym: Peeling

summary:
The epimacular membrane (EMM) is a degenerative condition associated with age, with a variable impact on vision. Treatment is surgery based and consists of a vitrectomy followed by a peeling of the epimacular membrane using a microgripper. Peeling of the internal limiting membrane (ILM) is an adjuvant action that is now frequently practiced and which is expected to increase the success rate of EMM surgery by reducing the risk of recurrence of EMM. Although ILM peeling does not seem to have an adverse effect on visual acuity, it is not totally without consequence, it involves the risk of histological disorganization of the retina at the origin of one or several microscotomas, which are themselves responsible for a final visual discomfort. These microscotomas, resulting in the perception of somewhat black spots visible near the fixed point or the fixed image, may be highlighted by microperimetry and would be a loss of functional opportunity for the patient.

In addition, recurrence of EMM, which the ILM peeling is supposed to diminish, does not alter the vision in half the patients. Furthermore, for those patients who are functionally affected by any such recurrence, a second epimacular membrane peeling surgery can be done.

The main objective of this study is to compare the difference in microscotoma(s) before surgery and 6 months later, between an "active ILM peeling" group and a "no ILM peeling" group. Given the more invasive nature of ILM peeling, the investigators believe that the rate of microscotomas in these patients is higher than those without peeling.

ReferenceCitation: Ducloyer JB, Ivan J, Poinas A, Lebreton O, Bonissent A, Fossum P, Volteau C, Tadayoni R, Creuzot-Garchet C, Le Mer Y, Perol J, Fortin J, Chiffoleau A, Billaud F, Ivan C, Weber M. Does internal limiting membrane peeling during epiretinal membrane surgery induce microscotomas on microperimetry? Study protocol for PEELING, a randomized controlled clinical trial. Trials. 2020 Jun 8;21(1):500. doi: 10.1186/s13063-020-04433-9.

family: Ducloyer

full_name: Jean-Baptiste Ducloyer

given: Jean-Baptiste

family: Ivan

full_name: Juliette Ivan

given: Juliette

family: Poinas

full_name: Alexandra Poinas

given: Alexandra

family: Lebreton

full_name: Olivier Lebreton

given: Olivier

family: Bonissent

full_name: Alexandre Bonissent

given: Alexandre

family: Fossum

full_name: Paul Fossum

given: Paul

family: Volteau

full_name: Christelle Volteau

given: Christelle

family: Tadayoni

full_name: Ramin Tadayoni

given: Ramin

family: Creuzot-Garchet

full_name: Catherine Creuzot-Garchet

given: Catherine

family: Le Mer

full_name: Yannick Le Mer

given: Yannick

family: Perol

full_name: Julien Perol

given: Julien

family: Fortin

full_name: June Fortin

given: June

family: Chiffoleau

full_name: Anne Chiffoleau

given: Anne

family: Billaud

full_name: Fanny Billaud

given: Fanny

full_name: Catherine Ivan

family: Weber

full_name: Michel Weber

given: Michel

evidence: oa repository (via OAI-PMH title and first author match)

repositories_institution:
PubMed Central - Europe PMC
Research Square - Research Square

location_facility: Fondation Ophtalmologique A. de Rothschild


title: A SINGLE ARM PHASE 2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF Nab®-PACLITAXEL, IN SUBJECTS WITH PREVIOUSLY TREATED METASTATIC COLORECTAL CANCER

summary: The purpose of this study is to evaluate the safety and efficacy of Abraxane (nab-paclitaxel) in subjects with previously treated metastatic colorectal cancer. Subjects will be placed into two separate cohorts based on their RAS mutation status.

ReferenceCitation: Ducreux M, Bennouna J, Adenis A, Conroy T, Lièvre A, Portales F, Jeanes J, Li L, Romano A. Efficacy and safety of nab-paclitaxel in patients with previously treated metastatic colorectal cancer: a phase II COLO-001 trial. Cancer Chemother Pharmacol. 2017 Jan;79(1):9-16. doi: 10.1007/s00280-016-3193-5. Epub 2016 Nov 19.

family: Ducreux

full_name: Michel Ducreux

family: Bennouna

full_name: Jaafar Bennouna

given: Jaafar

family: Adenis

full_name: Antoine Adenis

given: Antoine

family: Conroy

full_name: Thierry Conroy

given: Thierry

family: Lièvre

full_name: Astrid Lièvre

given: Astrid

family: Portales

full_name: Fabienne Portales

given: Fabienne

family: Jeanes

full_name: Julie Jeanes

given: Julie

family: Li

full_name: Li Li

given: Li

family: Romano

full_name: Alfredo Romano

given: Alfredo

journal_name: Cancer Chemotherapy and Pharmacology

lead_sponsor: Celgene

location_facility: Centre Oscar Lambret, Dept. de Cancerologie Digestive et Urologique

location_facility: Centre Regional de Lutte contre le Cancer Val d'Aurelle


title: Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting. A Multicenter,Randomized,Controled, Comparative, Double Blinded Study

summary:
Intranasal (IN) administration of opiates is an appealing non-invasive way of treating acute traumatic pain in prehospital and Emergency departments (ED).

The investigators hypothesize that IN administration of Sufentanil is equal as compared with Intra veinous (IV) administration of Morphine wich is widely recommended in ED.

The investigators study is a multicentric, comparative, randomized, double-blind, double-placebo study, comparing quality of analgesia in both groups 30 minutes after first administration of opiates.

The investigators also asses side effects and patient satisfaction in both groups.

ReferenceCitation: Blancher M, Maignan M, Clapé C, Quesada JL, Collomb-Muret R, Albasini F, Ageron FX, Fey S, Wuyts A, Banihachemi JJ, Bertrand B, Lehmann A, Bollart C, Debaty G, Briot R, Viglino D. Intranasal sufentanil versus intravenous morphine for acute severe trauma pain: A double-blind randomized non-inferiority study. PLoS Med. 2019 Jul 16;16(7):e1002849. doi: 10.1371/journal.pmed.1002849. eCollection 2019 Jul.

family: Blancher

full_name: Marc Blancher

given: Marc

family: Maignan

full_name: Maxime Maignan

given: Maxime

family: Clapé

full_name: Cyrielle Clapé

given: Cyrielle

family: Quesada

full_name: Jean-Louis Quesada

given: Jean-Louis

family: Collomb-Muret

full_name: Roselyne Collomb-Muret

given: Roselyne

family: Albasini

full_name: François Albasini

given: François

family: Ageron

full_name: François-Xavier Ageron

given: François-Xavier

family: Fey

full_name: Stephanie Fey

given: Stephanie

family: Wuyts

full_name: Audrey Wuyts

given: Audrey

family: Banihachemi

full_name: Jean-Jacques Banihachemi

given: Jean-Jacques

family: Bertrand

full_name: Barthelemy Bertrand

given: Barthelemy

family: Lehmann

full_name: Audrey Lehmann

family: Bollart

full_name: Claire Bollart

given: Claire

family: Debaty

full_name: Guillaume Debaty

given: Guillaume

family: Briot

full_name: Raphaël Briot

given: Raphaël

family: Viglino

full_name: Damien Viglino

given: Damien

currency_apc_doaj: USD

journal_name: PLOS Medicine

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - IRD - Institut de recherche pour le développement

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université de Lille

location_facility: Emergency Department - Hospital Saint Jean de Maurienne

location_facility: Emergency Department - University Hospital of Grenoble

location_facility: Emergency Department - Hospital Albertville

location_facility: Emergency Department - Hospital Chambéry


title: Comparison of Prostate Cancer Detection Rates Obtained With Multiparametric MRI Targeted Transrectal Ultrasound Biopsies and Systematic Transrectal Ultrasound Biopsies.

acronym: MURIELLE

summary: The purpose of the study is to show that 3 targeted biopsies on the suspicious image detected by IRM, guided by a fusion of MRI and ultrasound- images with the Koelis ® system, will get no lower rate of cancer detection than those obtained by 12 systematic transrectal ultrasound-guided biopsies of the prostate.

primary_purpose: Health Services Research

lead_sponsor: Assistance Publique - Hôpitaux de Paris

location_facility:
CHU Pitié salpêtrière
CHU Cochin
CHU Toulouse Rangueil
Chu Edouard Herriot
Clinique Pasteur
CHU Grenoble


title: Evaluation of Transcutaneous Electrical Stimulation in Post Stroke Dysphagia

acronym: TENSDEG

summary:
Oropharyngeal dysphagia induces aspirations which could be responsible of aspiration pneumonia and denutrition. It could be present in the majority of central neurological disease (degenerative or vascular disease), which explains that it is the first case of mortality in stroke. Two pilot studies realised by our research group aimed to demonstrate that sensitive transcutaneous electrical stimulation could improve swallowing coordination and reduce aspirations. This technique could be used at home.

The aim of this study is to demonstrate that sensitive electrical stimulation could improve oropharyngeal dysphagia in hemispheric stroke patients. 118 patients should be included in seven centers. Sensitive electrical stimulation will be applied either as active stimulation, either as a placebo. Active electrical stimulation will be realised at 80 hz during 30 minutes, under motor threshold and above sensitive threshold. It will be administrated via surface electrodes over the hyoid bone. Patients will be separated by randomisation.

Patients will be evaluated before and after 6 weeks of use. Methods will evaluation questionnaire, clinical examination and videofluoroscopy. The time of use will also be collected.

We wish to demonstrate that transcutaneous electrical stimulation is able to improve oropharyngeal dysphagia in stroke.

status: Terminated

lead_sponsor: University Hospital, Rouen

location_facility:
UH Limoges
UH Rouen
UH Bordeaux
AP-HP Fernand WIDAL
UH Toulouse
Centre les Herbiers


title: Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain

acronym: MYOTOX

summary: Myofascial pains are frequently found during the clinical examination of the patients presenting a painful chronic syndrome of the pelvis or the perineum. If the physiopathology of this component of the pain characterized by triggerpoints found in the clinical examination, remains uncertain; its coverage contributes to the improvement of the global pain of the patient. The physiotherapy can be useful but when it is not useful, we proposed injections of triggerpoints by local anesthetics. The injections of botulinum toxin on these triggerpoints have a legitimacy (action on the muscular cramp and action on the afferent fibers) but are they superior to the injections of local anesthetics of triggerpoints? The literature remains poor on the subject, justifying this randomized double-blind protocol comparing the efficacy of the botulinum toxin associated with a local anesthetic versus local anesthetic alone with a main criterion of evaluation in 2 months and a monthly follow-up as long as the patient remains improved and maximum in 6 months.

ReferenceCitation: Levesque A, Ploteau S, Michel F, Siproudhis L, Bautrant E, Eggermont J, Rabischong B, Volteau C, Perrouin-Verbe MA, Labat JJ. Botulinum toxin infiltrations versus local anaesthetic infiltrations in pelvic floor myofascial pain: Multicentre, randomized, double-blind study. Ann Phys Rehabil Med. 2021 Jan;64(1):101354. doi: 10.1016/j.rehab.2019.12.009. Epub 2020 Jan 22.

family: Levesque

full_name: Amélie Levesque

given: Amélie

family: Ploteau

full_name: Stéphane Ploteau

given: Stéphane

family: Michel

full_name: Fabrice Michel

given: Fabrice

family: Siproudhis

full_name: Laurent Siproudhis

given: Laurent

family: Bautrant

full_name: Eric Bautrant

given: Eric

family: Eggermont

full_name: Julie Eggermont

given: Julie

family: Rabischong

full_name: Benoit Rabischong

given: Benoit

family: Volteau

full_name: Christelle Volteau

given: Christelle

family: Perrouin-Verbe

full_name: Marie-Aimée Perrouin-Verbe

given: Marie-Aimée

family: Labat

full_name: Jean-Jacques Labat

journal_name: Annals of Physical and Rehabilitation Medicine

evidence: open (via crossref license)

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

publisher: Elsevier BV

publisher_dissemination: Elsevier

publisher_group: Elsevier

publisher_normalized: Elsevier

location_facility:
Clinique Axium
Clermont-Ferrand University Hospital
Rennes University Hospital
Besançon University Hospital
La Réunion University Hospital
Nantes University Hospital


title: Evaluation of Metabolomic Analysis in Early Diagnosis of ALS

acronym: METABALS

summary: This project is expected to answer the question of interest assays of metabolites in the CSF as a tool for early diagnosis and should show whether it is possible or not to use such markers in the blood or urine. These studies should also help shed light on the pathophysiological original early clinical disease. While ALS appears to be more a clinical syndrome that pathophysiological entity unique metabolic abnormalities identified could help identify mechanisms disrupted in which therapeutic interventions will be possible.

location_facility: Pôle Neurosciences et Spécialités ,Service de Neurologie,CHU d'Angers

location_facility: Service de Neurologie et Pathologie du Mouvement Clinique de Neurologie, Pôle des Neurosciences et de l'Appareil Locomoteur INSERM U 837

location_facility: Service de neurologie, CHU La Milétrie, POITIERS, Faculté de Médecine

location_facility: Centre de Recherche de l'Institut du Cerveau et de la moëlle UPMC Paris 6,Département des Maladies du Système Nerveux


title: Changes in Phenotype and Genotype of Breast Cancers During the Metastatic Process and Optimization of Therapeutic Targeting

summary: The primary objective is to compare the phenotype and genotype of the primary tumor with those of its metastases in order to optimize the treatment of metastatic disease, in patients presenting with first metastatic progression of breast cancer.

ReferenceCitation: Callens C, Driouch K, Boulai A, Tariq Z, Comte A, Berger F, Belin L, Bièche I, Servois V, Legoix P, Bernard V, Baulande S, Chemlali W, Bidard FC, Fourchotte V, Salomon AV, Brain E, Lidereau R, Bachelot T, Saghatchian M, Campone M, Giacchetti S, Zafrani BS, Cottu P. Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study. Genome Med. 2021 Mar 15;13(1):44. doi: 10.1186/s13073-021-00862-6.

family: Callens

full_name: Céline Callens

given: Céline

family: Driouch

full_name: Keltouma Driouch

given: Keltouma

family: Boulai

full_name: Anaïs Boulai

given: Anaïs

family: Tariq

full_name: Zakia Tariq

given: Zakia

family: Comte

full_name: Aurélie Comte

given: Aurélie

family: Berger

full_name: Frédérique Berger

given: Frédérique

family: Belin

full_name: Lisa Belin

given: Lisa

family: Bièche

full_name: Ivan Bièche

given: Ivan

family: Servois

full_name: Vincent Servois

given: Vincent

family: Legoix

full_name: Patricia Legoix

given: Patricia

family: Bernard

full_name: Virginie Bernard

given: Virginie

family: Baulande

full_name: Sylvain Baulande

given: Sylvain

family: Chemlali

full_name: Walid Chemlali

given: Walid

family: Bidard

full_name: François-Clément Bidard

given: François-Clément

family: Fourchotte

full_name: Virginie Fourchotte

family: Salomon

full_name: Anne Vincent- Salomon

given: Anne Vincent-

family: Brain

full_name: Etienne Brain

given: Etienne

family: Lidereau

full_name: Rosette Lidereau

given: Rosette

family: Bachelot

full_name: Thomas Bachelot

given: Thomas

family: Saghatchian

full_name: Mahasti Saghatchian

given: Mahasti

family: Campone

full_name: Mario Campone

given: Mario

family: Giacchetti

full_name: Sylvie Giacchetti

given: Sylvie

family: Zafrani

full_name: Brigitte Sigal Zafrani

given: Brigitte Sigal

family: Cottu

full_name: Paul Cottu

given: Paul

location_facility: INSTITUT DE CANCEROLOGIE DE L'OUEST René Gauducheau


title: Value of Tomosynthesis in Breast Lesion Characterization and Breast Cancer Staging

summary:
Study Rationale: an accurate breast cancer staging has a great impact in the management of a breast cancer. MRI is considered as the most sensible exam for this staging. However it has a low specificity and it may result in extra testing and stress for the patient, add to costs, and delay treatment. By contrast, Tomosynthesis is performed during the same time than mammography and has a good specificity. Although this modality is very promising, it has not been assessed in a population of consecutive patients.

Study objectives: To compare the diagnostic performance of preoperative bilateral Combo mode (MG+Tomosynthesis) versus mammography among women with breast cancer for the detection of additional multifocal, multicentric, and contralateral cancers.

ReferenceCitation: Fontaine M, Tourasse C, Pages E, Laurent N, Laffargue G, Millet I, Molinari N, Taourel P. Local Tumor Staging of Breast Cancer: Digital Mammography versus Digital Mammography Plus Tomosynthesis. Radiology. 2019 Jun;291(3):594-603. doi: 10.1148/radiol.2019182457. Epub 2019 Apr 9.

family: Fontaine

full_name: Marion Fontaine

given: Marion

family: Tourasse

full_name: Christophe Tourasse

given: Christophe

family: Pages

full_name: Emmanuelle Pages

given: Emmanuelle

family: Laurent

full_name: Nicolas Laurent

given: Nicolas

family: Laffargue

full_name: Guillaume Laffargue

given: Guillaume

family: Millet

full_name: Ingrid Millet

given: Ingrid

family: Molinari

full_name: Nicolas Molinari

family: Taourel

full_name: Patrice Taourel

given: Patrice

journal_name: Radiology

publisher: Radiological Society of North America (RSNA)

lead_sponsor: University Hospital, Montpellier

location_facility:
UH Montpellier
Jean Mermoz Hospital
UH Grenoble
Oscar Lambret Center
Hospital Valenciennes
Private Hospital oh Antony


title: Induction of Regulatory T Cells for the Treatment of Recently Diagnosed Type 1 Diabetes: Dose Finding Study of the Lowest Active Dose of IL-2 in Children

summary: Human recombinant interleukin-2 (rhIL-2) is a biological signalling protein playing a key role in the regulation of the immune system. At high doses, rhIL-2 activates the immune effectors T cells (TEFFS) while at low doses rhIL-2 induces and activates regulatory T cells (TREGS), a population of immune cells controlling the immune Teff response. In patients with Type 1 Diabetes (T1D), TREGS fail to control the autoimmune destruction by TEFFS of pancreatic beta-cells producing insulin. The investigator recently showed that rhIL-2 at low dose is well tolerated in patients with an autoimmune disease and in adults with established T1D, inducing TREGS without effects on TEFFS. The investigators aim to use rhIL-2 at low dose to induce/stimulate TREGS in young recently diagnosed T1D patients. This study will investigate the dose effect relationship of low dose rhIL-2 on TREG induction such as to optimize the risk benefit ratio of this treatment in T1D. Through Treg induction, the investigators aim to protect the remaining/regenerating pancreatic β-cells from autoimmune destruction, thus improving or even curing T1D.

ReferenceCitation: Rosenzwajg M, Salet R, Lorenzon R, Tchitchek N, Roux A, Bernard C, Carel JC, Storey C, Polak M, Beltrand J, Amouyal C, Hartemann A, Corbeau P, Vicaut E, Bibal C, Bougnères P, Tran TA, Klatzmann D. Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study. Diabetologia. 2020 Sep;63(9):1808-1821. doi: 10.1007/s00125-020-05200-w. Epub 2020 Jul 1.

family: Rosenzwajg

full_name: Michelle Rosenzwajg

given: Michelle

family: Salet

full_name: Randa Salet

given: Randa

family: Lorenzon

full_name: Roberta Lorenzon

given: Roberta

family: Tchitchek

full_name: Nicolas Tchitchek

family: Roux

full_name: Alexandra Roux

given: Alexandra

family: Bernard

full_name: Claude Bernard

given: Claude

family: Carel

full_name: Jean-Claude Carel

given: Jean-Claude

family: Storey

full_name: Caroline Storey

given: Caroline

family: Polak

full_name: Michel Polak

given: Michel

family: Beltrand

full_name: Jacques Beltrand

given: Jacques

family: Amouyal

full_name: Chloé Amouyal

given: Chloé

family: Hartemann

full_name: Agnès Hartemann

given: Agnès

family: Corbeau

full_name: Pierre Corbeau

given: Pierre

family: Vicaut

full_name: Eric Vicaut

given: Eric

family: Bibal

full_name: Cecile Bibal

given: Cecile

family: Bougnères

full_name: Pierre Bougnères

family: Tran

full_name: Tu-Anh Tran

given: Tu-Anh

family: Klatzmann

full_name: David Klatzmann

given: David

journal_name: Diabetologia

location_facility: Service d'endocrinologie pédiatrique - CHU de Necker

location_facility: Service d'endocrinologie Diabétologie pédiatrique CHU Robert Débré


title: CIRCE: Environmental, Metabolic and Nutritional Factors of Hepatocellular Carcinoma in Cirrhotic Patients

acronym: CIRCE

summary:
Available data do not allow carcinogenesis mechanisms in cirrhotic patients to be well understood in absence of studies taking into account all recognised factors. A large scale clinical, biochemical and molecular studies is potentially relevant to the understanding of nutrition, physical activity, body weight metabolic syndrome whatever the etiology of underlying cirrhosis. It will open new perspectives :

in prevention of hepatocellular carcinoma development in cirrhotic patients through dietary counselling and therapeutics of metabolic syndrome,
in early screening of hepatocellular carcinoma in cirrhotic patients through spectroscopic technology and later proteomic study resulting in an improvement of hepatocellular carcinoma prognosis.

lead_sponsor: Centre Hospitalier Universitaire Dijon

location_facility: Clinique médicale B. Hôpital Civil-Hôpitaux Universitaires


type: EudraCT Number

title: A Randomized, Double Blind, Controlled, Multi-center, Phase III Study to Assess Efficacy of Low Level Diode Laser (100 MW, 658 Nm), in the Prevention and Treatment of Radiochemotherapy-induced Mucositis in Head and Neck Cancer.

acronym: LaserMucite

summary: The purpose of the study is to assess in a randomized, double blind, controlled, multi-center, phase III study, the efficacy of low level diode laser (100 MW, 658 Nm), in the prevention and treatment of radiochemotherapy-induced mucositis for stage III and IV head and neck carcinomas.

ReferenceCitation: Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E. Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial. Radiat Oncol. 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2.

family: Legouté

full_name: Florence Legouté

given: Florence

family: Bensadoun

full_name: René-Jean Bensadoun

given: René-Jean

family: Seegers

full_name: Valérie Seegers

given: Valérie

family: Pointreau

full_name: Yoann Pointreau

given: Yoann

family: Caron

full_name: Delphine Caron

given: Delphine

family: Lang

full_name: Philippe Lang

given: Philippe

family: Prévost

full_name: Alain Prévost

given: Alain

family: Martin

full_name: Laurent Martin

given: Laurent

family: Schick

full_name: Ulrike Schick

given: Ulrike

family: Morvant

full_name: Benjamin Morvant

given: Benjamin

family: Capitain

full_name: Olivier Capitain

given: Olivier

family: Calais

full_name: Gilles Calais

given: Gilles

family: Jadaud

full_name: Eric Jadaud

journal_name: Radiation Oncology

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Archive ouverte HAL

repositories:
HAL
PubMed Central

repositories_institution: Le Centre pour la Communication Scientifique Directe - HAL - Diderot

location_facility: Institut de Cancerologie de l'Ouest Paul Papin

location_facility: Centre hospitalier universitaire La Milétrie


title: Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis.

acronym: Endophtalmitis

summary: One useful effect of early intravitreal corticotherapy is to diminish inflammatory complications after endophthalmitis, which may cause, at least in part, serious complications (retinal detachment, macular edema) which are, more than the infection, causes of the complications seen after acute endophthalmitis.

location_facility:
CHU de Nancy
CHU de Strasbourg
CHU de Grenoble
CHU de Saint Etienne
CHU
CHU de Besançon


title: A PHASE IB STUDY OF THE BTKi CC-292 COMBINED WITH LENALIDOMIDE IN ADULTS PATIENTS WITH RELAPSED/REFRACTORY B-CELL LYMPHOMA

acronym: CLEAR

summary: This is an open label, 3 + 3 dose escalation study, to determine the MTD, safety, efficacy and PK profiles for subjects with relapsed/refractory B-cell malignancies when using CC-292 and lenalidomide combination therapy. Subjects will be followed for disease progression and collection of second primary malignancy (SPM) events. This dose escalation will be followed by an exploratory expansion phase in 3 cohorts of 12 patients each.

location_facility:
CHU de Nantes
CHU de Lille
Hopital henri mondor
Institut Paoli Calmette
CHU Lyon Sud
CHU de Toulouse


title: A Prospective, Multicenter, Randomized, Controlled, Parallel-group, Open Label Trial Evaluating Benefits of Nasal High Flow Therapy (HFT) in Preoxygenation Before Tracheal Intubation in Acute Hypoxemic Respiratory Failure

acronym: PREOXYFLOW

summary:
Oro-tracheal intubation in intensive unit care(ICU) in acute hypoxemic respiratory failure after crash induction remains a critical event.

The aim of this study is to determine whether Nasal High Flow Therapy (HFT) Optiflow ® is more efficient than the face mask for preoxygenation before orotracheal intubation after crash induction in acute hypoxemic respiratory failure

ReferenceCitation: Vourc'h M, Asfar P, Volteau C, Bachoumas K, Clavieras N, Egreteau PY, Asehnoune K, Mercat A, Reignier J, Jaber S, Prat G, Roquilly A, Brule N, Villers D, Bretonniere C, Guitton C. High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med. 2015 Sep;41(9):1538-48. doi: 10.1007/s00134-015-3796-z. Epub 2015 Apr 14.

family: Vourc’h

full_name: Mickaël Vourc’h

given: Mickaël

family: Asfar

full_name: Pierre Asfar

given: Pierre

family: Volteau

full_name: Christelle Volteau

given: Christelle

family: Bachoumas

full_name: Konstantinos Bachoumas

given: Konstantinos

family: Clavieras

full_name: Noëmie Clavieras

given: Noëmie

family: Egreteau

full_name: Pierre-Yves Egreteau

given: Pierre-Yves

family: Asehnoune

full_name: Karim Asehnoune

given: Karim

family: Mercat

full_name: Alain Mercat

family: Reignier

full_name: Jean Reignier

given: Jean

family: Jaber

full_name: Samir Jaber

given: Samir

family: Prat

full_name: Gwenaël Prat

given: Gwenaël

family: Roquilly

full_name: Antoine Roquilly

given: Antoine

family: Brule

full_name: Noëlle Brule

given: Noëlle

family: Villers

full_name: Daniel Villers

given: Daniel

family: Bretonniere

full_name: Cédric Bretonniere

given: Cédric

family: Guitton

full_name: Christophe Guitton

given: Christophe

journal_name: Intensive Care Medicine

oa_host_type: repository

location_facility: Nantes Universitary Hospital, medical intensive care unit

location_facility: Nantes Universitary Hospital, surgical intensive care unit


title: Phase 2a Study Evaluating the Arsenic Trioxide (ATO) in Systemic Lupus (SLE)

acronym: LUPSENIC

summary:
Primary objectives :

To investigate the safety and the tolerability of ATO by IV infusions to patients with SLE,
To determine the maximum tolerated dose of ATO.

Secondary objectives :

Evaluation of the clinical and biological response of the SLE to ATO,
Time of relapse in case of positive response,
Determination of the efficacy,
Pharmacokinetic study of ATO.

ReferenceCitation: Hamidou M, Néel A, Poupon J, Amoura Z, Ebbo M, Sibilia J, Viallard JF, Gaborit B, Volteau C, Hardouin JB, Hachulla E, Rieger F. Safety and efficacy of low-dose intravenous arsenic trioxide in systemic lupus erythematosus: an open-label phase IIa trial (Lupsenic). Arthritis Res Ther. 2021 Mar 3;23(1):70. doi: 10.1186/s13075-021-02454-6.

family: Hamidou

full_name: Mohamed Hamidou

given: Mohamed

family: Néel

full_name: Antoine Néel

family: Poupon

full_name: Joel Poupon

given: Joel

family: Amoura

full_name: Zahir Amoura

given: Zahir

family: Ebbo

full_name: Mikael Ebbo

given: Mikael

family: Sibilia

full_name: Jean Sibilia

family: Viallard

full_name: Jean-Francois Viallard

given: Jean-Francois

family: Gaborit

full_name: Benjamin Gaborit

given: Benjamin

family: Hardouin

full_name: Jean Benoit Hardouin

given: Jean Benoit

family: Hachulla

full_name: Eric Hachulla

given: Eric

family: Rieger

full_name: François Rieger

given: François

journal_name: Arthritis Research & Therapy

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Francois Rabelais - Tours

location_facility:
CHRU de Lille
CHU de Marseille
CHU de Bordeaux
CHRU de Strasbourg
AP-HP - la Pitié-Salpétrière
Nantes University Hospital


title: A Phase II Open-label Single Arm Study of Sunitinib in Patients With Advanced Cholangiocarcinoma

acronym: SUN-CK

summary:
For patients with non-resectable cholangiocarcinoma, gemcitabine with cisplatin is considered as the reference treatment in first line chemotherapy. However, the outcomes of these patients remain limited and therefore more effective drugs are warranted. The context of the disease and current data on sunitinib suggest that sunitinib may have activity in patients with advanced non resectable cholangiocarcinoma.

Thereby, it is proposed to conduct an open label single arm trial aiming evidencing activity of sunitinib in such a patient population.

ReferenceCitation: Dreyer C, Sablin MP, Bouattour M, Neuzillet C, Ronot M, Dokmak S, Belghiti J, Guedj N, Paradis V, Raymond E, Faivre S. Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy. World J Hepatol. 2015 Apr 28;7(6):910-5. doi: 10.4254/wjh.v7.i6.910.

family: Dreyer

full_name: Chantal Dreyer

given: Chantal

journal_name: World Journal of Hepatology

oa_colors: green other

publisher: Baishideng Publishing Group Inc.

publisher_dissemination: Baishideng Publishing Group Inc.

publisher_group: Baishideng Publishing Group Inc.

publisher_normalized: Baishideng Publishing Group Inc.

lead_sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group

location_facility:
Hôpital Saint Antoine
Hôpital privé Jean Mermoz
CHU La Timone
Institut Gustave Roussy
Institut Mutualiste Montsouris
Hôpital Beaujon


title: Stretta In Reflux Uncontrolled by Intake of Inhibitors of Protons Pump (IPP).- The SIRUP Trial- Multicentric, Randomized, Double Blind, Prospective Study

acronym: SIRUP

summary: The aim of the study is to compare the Stretta procedure and the Sham procedure efficiency 6months post-procedure in reflux uncontrolled by intake of Inhibitors of Protons Pump (IPP) patients.

ReferenceCitation: Zerbib F, Sacher-Huvelin S, Coron E, Coffin B, Melchior C, Ponchon T, Cholet F, Chabrun E, Vavasseur F, Gorbatchef C, Zalar A, Mion F, Robaszkiewicz M, Le Rhun M, Leroy M, Paul Galmiche J, Bruley des Varannes S. Randomised clinical trial: oesophageal radiofrequency energy delivery versus sham for PPI-refractory heartburn. Aliment Pharmacol Ther. 2020 Aug;52(4):637-645. doi: 10.1111/apt.15936. Epub 2020 Jul 13.

name: Gastroenterology Department; CHU de Bordeaux; Centre Medico-chirurgical Magellan; Hôpital Haut-Lévêque; Université de Bordeaux; INSERM CIC 1401; Bordeaux France

family: Zerbib

full_name: Frank Zerbib

given: Frank

name: Gastroenterology Department; CHU de Nantes; Institut des Maladies de l’Appareil Digestif (IMAD); CIC1413; Université de Nantes; Nantes France

family: Sacher-Huvelin

full_name: Sylvie Sacher-Huvelin

given: Sylvie

family: Coron

full_name: Emmanuel Coron

given: Emmanuel

name: Gastroenterology Department; AP-HP; Hôpital Louis Mourier, Colombes, Université de Paris; Paris France

family: Coffin

full_name: Benoit Coffin

given: Benoit

name: Gastroenterology Department; Rouen University Hospital and INSERM CIC-CRB 1404 and INSERM U1073; Institute for Research and Innovation in Biomedicine; Normandy University; Rouen France

family: Melchior

full_name: Chloé Melchior

given: Chloé

name: Gastroenterology Department; CHU de Lyon; Hôpital Edouard Herriot; Université de Lyon; Lyon France

family: Ponchon

full_name: Thierry Ponchon

given: Thierry

name: Gastroenterology Department;  CHRU de Brest, Hôpital de la Cavale Blanche; Université de Brest; Brest France

family: Cholet

full_name: Franck Cholet

given: Franck

family: Chabrun

full_name: Edouard Chabrun

given: Edouard

family: Vavasseur

full_name: Fabienne Vavasseur

given: Fabienne

family: Gorbatchef

full_name: Caroline Gorbatchef

given: Caroline

family: Zalar

full_name: Alberto Zalar

given: Alberto

name: Digestive Physiology Department; Hospices Civils de Lyon; Université de Lyon; Inserm U1082 LabTau; Lyon France

family: Mion

full_name: François Mion

family: Robaszkiewicz

full_name: Michel Robaszkiewicz

given: Michel

family: Le Rhun

full_name: Marc Le Rhun

given: Marc

name: Methodology and Biostatistics Department; CHU de Nantes; Université de Nantes; Nantes France

family: Leroy

full_name: Maxime Leroy

given: Maxime

family: Paul Galmiche

full_name: Jean Paul Galmiche

given: Jean

family: Bruley des Varannes

full_name: Stanislas Bruley des Varannes

given: Stanislas

journal_name: Alimentary Pharmacology & Therapeutics

publisher: Wiley

publisher_dissemination: Wiley

publisher_group: Wiley

publisher_normalized: Wiley

location_facility:
Lyon Universitary Hospital
Nantes Universitary Hospital
APHP - Louis Mourier hospital
Bordeaux Universitary Hospital
Rouen Universitary Hospital
Brest universitary hospital


title: Prospective, Observational, Multicenter Trial Evaluating Autologous Stem Cell Transplantation for Myeloma Patients Over the Age of 65

acronym: LATMM

summary: Autologous stem cell transplantation remains the gold standard of treatment for newly diagnosed patients under the age of 65. Even though it is also regularly performed above the age of 65, there are very few data in this patient population. The investigators will capture safety and efficacy data in that setting.

ReferenceCitation: Garderet L, Beohou E, Caillot D, Stoppa AM, Touzeau C, Chretien ML, Karlin L, Moreau P, Fontan J, Blaise D, Polge E, Gueye MS, Ikhlef S, Marjanovic Z, Labopin M, Mohty M. Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study. Haematologica. 2016 Nov;101(11):1390-1397. Epub 2016 Sep 9.

location_facility:
Institut Paoli Calmette
CHU
Hôpital Saint Antoine


title: A Multicenter, Open-label, Single Arm, Long-term Extension Study of WA19926 to Describe Safety During Treatment With Tocilizumab in Patients With Early, Moderate to Severe Rheumatoid Arthritis

summary: This open-label, single arm, multicenter long-term extension study will evaluate the safety and efficacy of tocilizumab (RoActemra/Actemra) in participants with moderate to severe rheumatoid arthritis who have completed the 104-week WA19926 core study. Eligible participants will receive tocilizumab 8 mg/kg intravenously every 4 weeks for up to 104 weeks.

lead_sponsor: Hoffmann-La Roche


title: Early Assessment of Therapeutic Response of Patients With Soft Tissue Sarcoma According to CHOI Criteria: Retrospective Study of Feasibility

acronym: ProAcTyon

summary: Non-interventional study consisting of a population of patients who had received for soft tissue sarcoma by at least 2 courses of Yondelis® at a dose of 1.5 mg / m² / 3 weeks after failure or intolerance to doxorubicin / ifosfamide from 2007 to 2011.

time_perspective: Retrospective

location_facility:
Henri Becquerel Center
Antoine Lacassagne Center
Curie Institute
Bergonie Institute
Oscar Lambret Center
Cancer Institute of the West


title: tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients: a Randomized, Double-blind, Placebo Controlled Study

acronym: STICODEP

summary:
The aim is to investigate the effect of transcranial Direct Current Stimulation (tDCS) applied at the anodal left CDLPF of patients with resistant depression compared to patients treated with conventional therapy. The tDCS is used in add-on drug treatment in resistant depression stabilized for 4 weeks (antidepressant as SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonine-Norepinephrine Reuptake Inhibitors) for unipolar patients and lithium for bipolar patients). The delay of 4 weeks is a minimum to observe a non-response. Moreover, in term of ethical point of view, it's difficult to wait 6 to 8 weeks to observe the non-response to treatment.

This is a randomized 2-arm parallel, double blind study comparing 2 groups of 60 patients (48 unipolar plus 12 bipolar patients per group. Patients will be selected in the psychiatric department of the University Hospital of different centers and the two groups are matched for age (+/- 5 years), gender and depression diagnosis (unipolar vs bipolar).

After giving informed consent, patients will be evaluated by a psychiatrist using the Hamilton Depression Rating Scale (HDRS), Montgomery Asberg Depression Rating Scale (MADRS), the STAI and Beck Depression Inventory (BDI) and for bipolar patient only, by the Young Mania Rating Scale (YMRS). The complete assessment takes 50 minutes. A neuropsychologist assessment will be also realized during 20 minutes using the Crossing of Test (COT), the Trail Making Test (TMT), the Isaacs Set Test (IST) and the Cardebat fluency Task.

After locating the left DLPFC, treatment with active tDCS with a current of 2 mA or sham will be directed by 30-minute session. A psychometric assessment will be conducted again at the end of treatment week and 4, 12 and finally 24 weeks after stopping treatment. The neuropsychologist assessment will be conducted again 4 weeks after the end of treatment. Scales of comfort and acceptability will also be proposed to the patient to determine whether any gene is caused by this treatment.

These people will be recruited on a voluntary basis, after notification and consent in the 6 research centers. This study was conducted over a period of 36 months.

This study was supporting by a grant from the French Hospital Program of Clinical Reseach (PHRC N/2011-60-2011-A01074-37)

lead_sponsor: Centre Hospitalier Universitaire de Besancon

location_facility: Centre Hospitalier Guillaume Régnier - Rennes - Service Hospitalo-Universitaire de Psychiatrie

location_facility: Etablissement Public de Santé Mentale - Unité de Recherche Clinique

location_facility: CHRU Besancon - Service de Psychiatrie - Centre Investigation Clinique Innovation Technologique (CIC-IT808)

location_facility: Hôpital Civil de Strasbourg - Service de Psychiatrie

location_facility: CHU Grenoble - Clinique de Psychiatrie de l'Adulte


lead_sponsor: Institut Cancerologie de l'Ouest

acronym: PITAC

location_facility:
Hôpital Laennec
Centre Oscar Lambret
Centre Hospitalier
Polyclinique
ICO Paul Papin
Institut Bergonié

source: euctr

title: Comparison of Two Types of Intrathecal Morphine Administration by Pump for Analgesia in Cancer Patients With Failure of Conventional Analgesic Therapy.

summary: The aim of this study is to compare intrathecal morphine administration: using a pump with continuous or programmable flow.


title: Prospective Randomized Trial Comparing Unilateral and Bilateral Neuromodulation Tests in the Treatment of Refractory Idiopathic Overactive Bladder

acronym: HAVIR Bi

summary: The primary objective of this study is to compare the efficacy of unilateral and bilateral neuromodulation tests at 1 month.

lead_sponsor: Centre Hospitalier Universitaire de Nīmes

location_facility: APHP - Groupe Hospitalier Pitié-Salpetrière

location_facility: CHU de Nîmes - Hôpital Universitaire Carémeau


title: Evaluation of Two Strategies for Umbilical Cord Care : Dry Cord Care Versus Antiseptic on the Incidence of Omphalitis in Healthy Term Newborn

acronym: NEOCORD

summary: At birth, the umbilical cord is cut, separating physically and symbolically the mother of his child. Before cord drop, umbilical area is a possible way of bacterial infection. Thus, umbilical cord infections constitute a major cause of neonatal morbidity and mortality in developing countries. In industrialized countries, omphalitis cases have almost disappeared whatever cord care strategies. At this day, care practices appear extremely different between countries, based more on habits and convictions that on evidence-based medicine. The investigators propose to conduct a non inferiority multicenter clustered crossed randomized study. Observations sessions will be performed on two consecutive periods of 5 months: 4 months of recruitment and 1 month follow-up. Main objective is to demonstrate that dry cord care practice would not expose to a higher risk of omphalitis than antiseptic based care approach. The purpose of NEOCORD study is a simplification of cord care for paramedical teams and parents, but also a significant reduction of costs in a medico-economic approach.

ReferenceCitation: Gras-Le Guen C, Caille A, Launay E, Boscher C, Godon N, Savagner C, Descombes E, Gremmo-Feger G, Pladys P, Saillant D, Legrand A, Caillon J, Barbarot S, Roze JC, Giraudeau B. Dry Care Versus Antiseptics for Umbilical Cord Care: A Cluster Randomized Trial. Pediatrics. 2017 Jan;139(1). pii: e20161857. doi: 10.1542/peds.2016-1857.

family: Gras-Le Guen

full_name: Christèle Gras-Le Guen

given: Christèle

family: Caille

full_name: Agnès Caille

given: Agnès

family: Launay

full_name: Elise Launay

given: Elise

family: Boscher

full_name: Cécile Boscher

given: Cécile

family: Godon

full_name: Nathalie Godon

given: Nathalie

family: Savagner

full_name: Christophe Savagner

given: Christophe

family: Descombes

full_name: Emmanuelle Descombes

given: Emmanuelle

family: Gremmo-Feger

full_name: Gisèle Gremmo-Feger

given: Gisèle

family: Pladys

full_name: Patrick Pladys

given: Patrick

family: Saillant

full_name: Dominique Saillant

given: Dominique

family: Legrand

full_name: Arnaud Legrand

given: Arnaud

family: Caillon

full_name: Jocelyne Caillon

given: Jocelyne

family: Barbarot

full_name: Sébastien Barbarot

given: Sébastien

family: Roze

full_name: Jean Christophe Roze

given: Jean Christophe

family: Giraudeau

full_name: Bruno Giraudeau

given: Bruno

journal_name: Pediatrics

publisher: American Academy of Pediatrics (AAP)

publisher_dissemination: American Academy of Pediatrics (AAP)

publisher_group: American Academy of Pediatrics (AAP)

publisher_normalized: American Academy of Pediatrics (AAP)

location_facility:
Dr DESCOMBES-BARROSO Emmanuelle
Pr SALIBA Elie
Pr PLADYS Patrick
Dr GRAS-LEGUEN
Dr GREMMO-FREGER Gisèle
Dr SAVAGNER Christophe


title: Observational and Comparative Study on the Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (Localized Infections Versus Bacteremia)

acronym: ORISA

summary: The primary objective of this study is to detect differences in anti-S. aureus antibody assays (IgM, IgA, IgG and its subclasses) between (1) a group of patients with bacteremia due to a chronic wound (cases) and (2) a group of patients with localized chronic wound infections (control).

location_facility: CHU de Nîmes - Hôpital Universitaire de Réadaptation du Grau du Roi


acronym: BPOP

summary: The purpose of the study is to determine the efficacity of a simple blind technic of loco regional anaesthesia of the sciatic nerve compared to the gold standard in emergency medecine : the intravenous morphine for treated the severe pain of leg, ankle or foot trauma in the prehospital setting and mountain rescue.

lead_sponsor: Centre Hospitalier Annecy Genevois

location_facility: Centre Hospitalier de la Region d'Annecy

location_facility: Centre Hospitalier Universitaire de GRENOBLE

location_facility: Centre Hospitalier d'Albertville moutiers


title: Double Blind Randomized Controlled Trial Comparing "Atropine+Propofol" Versus "Atropine+Atracurium+Sufentanil" as a Premedication Prior to Semi-urgent or Elective Endotracheal Intubation of Term and Preterm Newborns

acronym: PRETTINEO

summary:
Multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to endotracheal intubation of the neonate.

Primary outcome: pulse oxymetry value < 80% for more than 60 seconds. Secondary outcomes: number of attempts, duration of the procedure, changes in physiologic parameters, short- and long-term neurodevelopmental outcome.

Hypothesis: "atropine + propofol" compared to "atropine+atracurium+sufentanil" will significantly reduce the frequency of severe hypoxemia.

ReferenceCitation: Durrmeyer X, Breinig S, Claris O, Tourneux P, Alexandre C, Saliba E, Beuchée A, Jung C, Levy C, Marchand-Martin L, Marcoux MO, Dechartres A, Danan C; PRETTINEO Research Group. Effect of Atropine With Propofol vs Atropine With Atracurium and Sufentanil on Oxygen Desaturation in Neonates Requiring Nonemergency Intubation: A Randomized Clinical Trial. JAMA. 2018 May 1;319(17):1790-1801. doi: 10.1001/jama.2018.3708.

name: Neonatal Intensive Care Unit, CHI Créteil, CRETEIL, France

name: INSERM, U1153, Obstetrical, Perinatal and Pediatric Epidemiology Team, Epidemiology and Biostatistics Sorbonne, Paris Descartes University, France

family: Durrmeyer

full_name: Xavier Durrmeyer

given: Xavier

name: Pediatric and Neonatal Intensive Care Unit, CHU Toulouse, Toulouse, France

family: Breinig

full_name: Sophie Breinig

given: Sophie

name: Neonatal Intensive Care Unit, Hospices civils de Lyon, Lyon, France

family: Claris

full_name: Olivier Claris

given: Olivier

name: Neonatal Intensive Care Unit, CHU Amiens, Amiens, France

family: Tourneux

full_name: Pierre Tourneux

given: Pierre

name: Neonatal Intensive Care Unit, CHU Caen, Caen, France

family: Alexandre

full_name: Cénéric Alexandre

given: Cénéric

name: Neonatal Intensive Care Unit, CHU Tours, Tours, France

family: Saliba

full_name: Elie Saliba

given: Elie

name: Neonatal Intensive Care Unit, CHU Rennes, Rennes, France

family: Beuchée

full_name: Alain Beuchée

given: Alain

name: Clinical Research Center, CHI Créteil, Créteil, France

family: Jung

full_name: Camille Jung

given: Camille

name: IMRB- GRC GEMINI, Université Paris Est, Créteil, France

family: Levy

full_name: Corinne Levy

given: Corinne

family: Marchand-Martin

full_name: Laetitia Marchand-Martin

given: Laetitia

family: Marcoux

full_name: Marie-Odile Marcoux

given: Marie-Odile

name: INSERM, U1153, METHODS Team, Epidemiology and Statistics Sorbonne Paris Cité Research Center, Paris Descartes University, Hotel-Dieu Hospital (AP-HP), France.

family: Dechartres

full_name: Agnes Dechartres

given: Agnes

family: Danan

full_name: Claude Danan

given: Claude

ReferenceCitation: Tauzin M, Marchand-Martin L, Lebeaux C, Breinig S, Claris O, Tourneux P, Alexandre C, Levy C, Jung C, Dechartres A, Durrmeyer X; PREmedication Trial for Tracheal Intubation of the NEOnate Research Group. Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial. J Pediatr. 2021 Apr;231:273-277.e3. doi: 10.1016/j.jpeds.2020.12.001. Epub 2020 Dec 8.

family: Tauzin

full_name: Manon Tauzin

given: Manon

family: Lebeaux

full_name: Cécile Lebeaux

lead_sponsor: Centre Hospitalier Intercommunal Creteil

location_facility: Réanimation Pédiatrique et Néonatale de l'hôpital Clochevile, Centre Hospitalier Universitaire de Tours

location_facility: Médecine Néonatale et Réanimation Pédiatrique Polyvalente, CHU Amiens Nord

location_facility: Centre Hospitalier Intercommunal de Créteil


title: Evaluation of Interests of the Functional Insulin Therapy (FIT Therapy) on Metabolic Control, Hypoglycemia Prevention and Life Quality of Diabetics Children Insulin-dependent Treated With Insulin Pump.

acronym: DIABFIT

summary: Evaluation of interests of the functional insulin therapy (FIT Therapy) on metabolic control, hypoglycemia prevention and life quality of diabetics children insulin-dependent treated with insulin pump.

ReferenceCitation: Langewitz W, Wössmer B, Iseli J, Berger W. Psychological and metabolic improvement after an outpatient teaching program for functional intensified insulin therapy (FIT). Diabetes Res Clin Pract. 1997 Sep;37(3):157-64.

ReferenceCitation: Hartemann-Heurtier A, Sachon C, Masseboeuf N, Corset E, Grimaldi A. Functional intensified insulin therapy with short-acting insulin analog: effects on HbA1c and frequency of severe hypoglycemia. An observational cohort study. Diabetes Metab. 2003 Feb;29(1):53-7.

ReferenceCitation: Sämann A, Mühlhauser I, Bender R, Kloos Ch, Müller UA. Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation study. Diabetologia. 2005 Oct;48(10):1965-70. Epub 2005 Aug 18.

ReferenceCitation: Lowe J, Linjawi S, Mensch M, James K, Attia J. Flexible eating and flexible insulin dosing in patients with diabetes: Results of an intensive self-management course. Diabetes Res Clin Pract. 2008 Jun;80(3):439-43. doi: 10.1016/j.diabres.2008.02.003. Epub 2008 Mar 18.

ReferenceCitation: Grimm JJ, Ybarra J, Berné C, Muchnick S, Golay A. A new table for prevention of hypoglycaemia during physical activity in type 1 diabetic patients. Diabetes Metab. 2004 Nov;30(5):465-70.

lead_sponsor: University Hospital, Angers

location_facility: University Hospital of Angers Service of Pediatric Diabetology and Endocrinology


title: Management of Nausea and Vomiting Chemotherapy-induced in Normandy

acronym: NAVI

summary: The objective of this study was to evaluate the various parameters involved in the occurrence of nausea / vomiting during the first cycle of chemotherapy for solid tumors or hematologic among a group of chemotherapy-naive patients, despite anti standardized-emetics protocols.

lead_sponsor: Centre Francois Baclesse

location_facility:
Centre hospitalier public du cotentin
Centre François Baclesse
Centre de la Baie
Centre Maurice Tubiana
Centre Jacques Monod
Centre hospitalier


title: Evaluation of Language and Sensorimotor Constraints of Very Premature Babies at the Age of 3 Years 1 / 2 Without Cerebral Palsy. Randomised Study of Stimulation Training Implicit in Children Vulnerable

acronym: LAMOPRESCO

summary:
The preterm children have more difficulty minor neurological developmental than the general population even without cerebral palsy. Their oral language difficulties of language and writing have been little studied. The investigators propose to study spoken language has 3 years 1/2 and stimulate or not (depending on randomization) children with phonological weaknesses notemment language. The investigators will evaluate stimulation protocol implied short and precise language in a re-education "say and do" in 20 sessions. A new evaluation of language (BILO and N-EEL), sensorimotor and cognitive constraints (KABC) will be performed at 4 years.

Early intervention on the basis of precise language before closing the window developmental (<5 years) is expected to improve as a result of language and cognitive development of preterm infants.

ReferenceCitation: Charollais A, Stumpf MH, Beaugrand D, Lemarchand M, Radi S, Pasquet F, Khomsi A, Marret S. [Evaluation of language at 6 years in children born prematurely without cerebral palsy: prospective study of 55 children]. Arch Pediatr. 2010 Oct;17(10):1433-9. doi: 10.1016/j.arcped.2010.06.012. Epub 2010 Aug 16. French.

location_facility:
University Hospital
Centre Jacques Cartier


title: Evaluation of Post Traumatic Stress Among the Nearest Relatives of Brain-dead, Withdrawal of Life Support, and Sudden Death Patients

summary: This study concerns the nearest relatives of patients who have passed away within 3 days of admission to an ICU due to: (1) brain death with multiple organ donation +/- tissues or (2) death via limitation and / or cessation of active treatment (LATA) without brain death or (3) sudden death of a previously healthy patient (no physical or mental limitations; MacCabe score = 0) within 3 days of admission to ICU without LATA nor brain death. Our primary objective is to determine the proportion of nearest relatives at risk for post traumatic stress disorder as defined by an Impact of Event Scale score greater than 37, and to compare this factor between the three above-mentioned groups.

location_facility: Centre Hospitalier Universitaire de Nîmes

location_facility: Assistance Publique - Hopitaux de Marseille

location_facility: Hôpital Gui De Chauliac (CHU de Montpellier)


title: A Phase II, Randomized, Placebo-controlled Trial of the Safety, Efficacy, Pharmacodynamics and Pharmacokinetics of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A.

summary: The present trial is a randomized, placebo-controlled study evaluating 3 different doses of PXT3003 in patients with CMT1A disease.

ReferenceCitation: Attarian S, Vallat JM, Magy L, Funalot B, Gonnaud PM, Lacour A, Péréon Y, Dubourg O, Pouget J, Micallef J, Franques J, Lefebvre MN, Ghorab K, Al-Moussawi M, Tiffreau V, Preudhomme M, Magot A, Leclair-Visonneau L, Stojkovic T, Bossi L, Lehert P, Gilbert W, Bertrand V, Mandel J, Milet A, Hajj R, Boudiaf L, Scart-Grès C, Nabirotchkin S, Guedj M, Chumakov I, Cohen D. An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A. Orphanet J Rare Dis. 2014 Dec 18;9:199. doi: 10.1186/s13023-014-0199-0. Erratum in: Orphanet J Rare Dis. 2016;11(1):92.

family: Attarian

full_name: Shahram Attarian

given: Shahram

family: Vallat

full_name: Jean-Michel Vallat

given: Jean-Michel

family: Magy

full_name: Laurent Magy

given: Laurent

family: Funalot

full_name: Benoît Funalot

given: Benoît

family: Gonnaud

full_name: Pierre-Marie Gonnaud

given: Pierre-Marie

family: Lacour

full_name: Arnaud Lacour

given: Arnaud

family: Péréon

full_name: Yann Péréon

given: Yann

family: Dubourg

full_name: Odile Dubourg

given: Odile

family: Pouget

full_name: Jean Pouget

given: Jean

family: Micallef

full_name: Joëlle Micallef

given: Joëlle

family: Franques

full_name: Jérôme Franques

given: Jérôme

family: Lefebvre

full_name: Marie-Noëlle Lefebvre

given: Marie-Noëlle

family: Ghorab

full_name: Karima Ghorab

given: Karima

family: Al-Moussawi

full_name: Mahmoud Al-Moussawi

given: Mahmoud

family: Tiffreau

full_name: Vincent Tiffreau

given: Vincent

family: Preudhomme

full_name: Marguerite Preudhomme

given: Marguerite

family: Magot

full_name: Armelle Magot

given: Armelle

family: Leclair-Visonneau

full_name: Laurène Leclair-Visonneau

given: Laurène

family: Stojkovic

full_name: Tanya Stojkovic

given: Tanya

family: Bossi

full_name: Laura Bossi

given: Laura

family: Lehert

full_name: Philippe Lehert

given: Philippe

family: Gilbert

full_name: Walter Gilbert

given: Walter

family: Bertrand

full_name: Viviane Bertrand

given: Viviane

family: Mandel

repository_institution: University of Melbourne - Minerva Access

repository_institution: Harvard University - Digital Access to Scholarship at Harvard (DASH)

location_facility:
Hôpital Roger Salengro
Groupe Hospitalier Pitié-Salpétrière
Hôpital La Timone
CHU Dupuytren
Hôtel Dieu
CHU Lyon Sud


type: Registry Identifier

title: Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

acronym: EXSAL

summary: The purpose of this study is to determine proportion of patients presented a search allelic imbalance of expression of genes BRCA 1 and 2 in population with hereditary breast and/or ovarian cancer risk and negative for deletion mutation BRCA 1 and 2 genes

location_facility:
Centre Hospitalier
Centre Eugène MARQUIS
Centre Henri BECQUEREL
Dr Pascaline BERTHET
CHU