title: Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) Comparing the Efficacy and Safety of Two Blinded Doses of Dabigatran Etexilate With Open Label Warfarin for the Prevention of Stroke and Systemic Embolism in Patients With Non-valvular Atrial Fibrillation: Prospective, Multi-centre, Parallel-group, Non-inferiority Trial (RE-LY Study)

summary: The primary objective of this trial is to demonstrate the efficacy and safety of dabigatran etexilate in patients with non-valvular atrial fibrillation for the prevention of stroke and systemic embolism.

ReferenceCitation: Reinhardt SW, Desai NR, Tang Y, Jones PG, Ader J, Spertus JA. Personalizing the decision of dabigatran versus warfarin in atrial fibrillation: A secondary analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) trial. PLoS One. 2021 Aug 19;16(8):e0256338. doi: 10.1371/journal.pone.0256338. eCollection 2021.

family: Reinhardt

full_name: Samuel W. Reinhardt

given: Samuel W.

family: Desai

full_name: Nihar R. Desai

given: Nihar R.

family: Tang

full_name: Yuanyuan Tang

given: Yuanyuan

family: Jones

full_name: Philip G. Jones

given: Philip G.

family: Ader

full_name: Jeremy Ader

given: Jeremy

family: Spertus

full_name: John A. Spertus

given: John A.

journal_name: PLOS ONE

license: cc-by

license_normalized: cc-by

publisher: Public Library of Science (PLoS)

publisher_dissemination: Public Library of Science

publisher_group: Public Library of Science

publisher_normalized: Public Library of Science

title: Personalizing the decision of dabigatran versus warfarin in atrial fibrillation: A secondary analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) trial

ReferenceCitation: Pol T, Hijazi Z, Lindbäck J, Oldgren J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Siegbahn A, Wallentin L. Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. Cardiovasc Res. 2021 Aug 6. pii: cvab262. doi: 10.1093/cvr/cvab262. [Epub ahead of print]

name: Department of Medical Sciences, Cardiology, Uppsala University, Uppsala Science Park, SE-752 37 Uppsala, Sweden

name: Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden

family: Pol

full_name: Tymon Pol

given: Tymon

family: Hijazi

full_name: Ziad Hijazi

given: Ziad

family: Lindbäck

full_name: Johan Lindbäck

given: Johan

family: Oldgren

full_name: Jonas Oldgren

given: Jonas

name: Duke Clinical Research Institute, Duke Health, Durham, NC, USA

family: Alexander

full_name: John H Alexander

given: John H

name: Population Health Research Institute, Hamilton, Canada

family: Connolly

full_name: Stuart J Connolly

given: Stuart J

family: Eikelboom

full_name: John W Eikelboom

given: John W

name: Thomas Jefferson University, Philadelphia, PA, USA

name: Cardiovascular Medicine, Lankenau Institute for Medical Research, Wynnewood, PA, USA

family: Ezekowitz

full_name: Michael D Ezekowitz

given: Michael D

family: Granger

full_name: Christopher B Granger

given: Christopher B

family: Lopes

full_name: Renato D Lopes

given: Renato D

family: Yusuf

full_name: Salim Yusuf

given: Salim

name: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden

family: Siegbahn

title: Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation

ReferenceCitation: Millenaar D, Schumacher H, Brueckmann M, Eikelboom JW, Ezekowitz M, Slawik J, Ewen S, Ukena C, Wallentin L, Connolly S, Yusuf S, Böhm M. Cardiovascular Outcomes According to Polypharmacy and Drug Adherence in Patients with Atrial Fibrillation on Long-Term Anticoagulation (from the RE-LY Trial). Am J Cardiol. 2021 Jun 15;149:27-35. doi: 10.1016/j.amjcard.2021.03.024. Epub 2021 Mar 20.

title: Cardiovascular Outcomes According to Polypharmacy and Drug Adherence in Patients with Atrial Fibrillation on Long-Term Anticoagulation (from the RE-LY Trial)

ReferenceCitation: Pol T, Hijazi Z, Lindbäck J, Alexander JH, Bahit MC, De Caterina R, Eikelboom JW, Ezekowitz MD, Gersh BJ, Granger CB, Hylek EM, Lopes R, Siegbahn A, Wallentin L. Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas. Open Heart. 2021 Mar;8(1). pii: e001471. doi: 10.1136/openhrt-2020-001471.

repository_institution: Uppsala University - Uppsala University Publications

repositories_institution: Uppsala University - Uppsala University Publications

title: Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas

ReferenceCitation: Hijazi Z, Wallentin L, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Pol T, Yusuf S, Oldgren J, Siegbahn A. Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation. J Am Heart Assoc. 2020 Dec 15;9(24):e018984. doi: 10.1161/JAHA.120.018984. Epub 2020 Dec 9.

name: Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden

name: Uppsala Clinical Research Center Uppsala University Uppsala Sweden

name: Duke Clinical Research InstituteDuke Health Durham NC

name: Population Health Research Institute Hamilton ON Canada

name: Thomas Jefferson University Philadelphia PA

name: Cardiovascular Medicine Lankenau Institute for Medical Research Wynnewood PA

name: Department of Medical Sciences Clinical Chemistry and Science for Life Laboratory Uppsala University Uppsala Sweden

journal_name: Journal of the American Heart Association

publisher: Ovid Technologies (Wolters Kluwer Health)

title: Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation

ReferenceCitation: Wallentin L, Lindbäck J, Eriksson N, Hijazi Z, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Oldgren J, Siegbahn A. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020 Nov 1;41(41):4037-4046. doi: 10.1093/eurheartj/ehaa697.

name: Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden

name: Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada

name: Thomas Jefferson Medical College and the Heart Center, Wynnewood, PA, USA

name: Duke Clinical Research Institute, Duke University Medical Center, Duke Health, Durham, NC, USA

title: Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

ReferenceCitation: Böhm M, Brueckmann M, Eikelboom JW, Ezekowitz M, Fräßdorf M, Hijazi Z, Hohnloser SH, Mahfoud F, Schmieder RE, Schumacher H, Wallentin L, Yusuf S. Cardiovascular outcomes, bleeding risk, and achieved blood pressure in patients on long-term anticoagulation with the thrombin antagonist dabigatran or warfarin: data from the RE-LY trial. Eur Heart J. 2020 Aug 7;41(30):2848-2859. doi: 10.1093/eurheartj/ehaa247.

name: Klinik für Innere Medizin III, Saarland University Medical Center, Kirrberger Str. 1, 66421 Homburg, Germany

name: Medicine CardioMetabolism & Respiratory, Boehringer Ingelheim International GmbH, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany

name: Faculty of Medicine Mannheim, Heidelberg University, Grabengasse 1, 69117 Heidelberg, Germany

name: Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton Health Sciences – King West, PO Box 2000, Hamilton, Ontario L8N 3Z5, Canada

name: Sidney Kimmel Medical College at Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA

name: Lankenau Medical Center, 100 East Lancaster Avenue, Wynnewood, PA 19096, USA

name: CardioMetabolism & Respiratory Medicine, Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Straße 173, 55216 Ingelheim am Rhein, Germany

name: Department of Medical Sciences, UCR Uppsala Clinical Research Center, Uppsala Science Park, Hubben, Dag Hammarskjölds väg 38, SE-751 85 Uppsala, Sweden

name: Department of Cardiology, UCR Uppsala Clinical Research Center, Uppsala Science Park, Hubben, Dag Hammarskjölds väg 38, SE-751 85 Uppsala, Sweden

name: Department of Cardiology, Goethe-Universität Frankfurt am Main, 60629 Frankfurt/Main, Germany

name: Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander University, Schloßplatz 4, 91054 Erlangen, Germany

name: Statistical Consultant, 55216 Ingelheim, Germany

ReferenceCitation: Stam-Slob MC, Connolly SJ, van der Graaf Y, van der Leeuw J, Dorresteijn JAN, Eikelboom JW, Peters RJG, Alings M, Visseren FLJ. Individual Treatment Effect Estimation of 2 Doses of Dabigatran on Stroke and Major Bleeding in Atrial Fibrillation. Circulation. 2019 Jun 18;139(25):2846-2856. doi: 10.1161/CIRCULATIONAHA.118.035266. Epub 2019 May 3.

name: Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands (M.C.S.-S., J.v.d.L., J.A.N.D., F.L.J.V.).

name: Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (S.J.C., J.W.E.).

name: Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands (Y.v.d.G., M.A.).

name: Department of Cardiology, Academic Medical Center/ University of Amsterdam, The Netherlands (R.J.G.P.).

title: Individual Treatment Effect Estimation of 2 Doses of Dabigatran on Stroke and Major Bleeding in Atrial Fibrillation

ReferenceCitation: Hijazi Z, Verdecchia P, Oldgren J, Andersson U, Reboldi G, Di Pasquale G, Mazzotta G, Angeli F, Eikelboom JW, Ezekowitz MD, Connolly SJ, Yusuf S, Wallentin L. Cardiac Biomarkers and Left Ventricular Hypertrophy in Relation to Outcomes in Patients With Atrial Fibrillation: Experiences From the RE - LY Trial. J Am Heart Assoc. 2019 Jan 22;8(2):e010107. doi: 10.1161/JAHA.118.010107.

name: Department of Medicine Hospital of Assisi Italy

name: Department of Medicine University of Perugia Italy

name: Department of Cardiology Maggiore Hospital Bologna Italy

name: Department of Cardiology and Cardiovascular Pathophysiology University of Perugia Perugia Italy

name: Population Health Research Institute Hamilton Ontario Canada

name: Thomas Jefferson Medical College and the Heart Center Wynnewood PA

repository_institution: KTH Royal Institute of Technology - KTH Publication Database DiVA

repositories_institution: KTH Royal Institute of Technology - KTH Publication Database DiVA

title: Cardiac Biomarkers and Left Ventricular Hypertrophy in Relation to Outcomes in Patients With Atrial Fibrillation: Experiences From the RE‐LY Trial

ReferenceCitation: Kent AP, Brueckmann M, Fraessdorf M, Connolly SJ, Yusuf S, Eikelboom JW, Oldgren J, Reilly PA, Wallentin L, Ezekowitz MD. Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation. J Am Coll Cardiol. 2018 Jul 17;72(3):255-267. doi: 10.1016/j.jacc.2018.04.063. Epub 2018 Jul 9.

journal_name: Journal of the American College of Cardiology

title: Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation

ReferenceCitation: Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, Ezekowitz MD, Reilly PA, Yusuf S, Wallentin L. Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time-A RE-LY trial analysis. Am Heart J. 2018 Apr;198:169-177. doi: 10.1016/j.ahj.2017.10.015. Epub 2018 Jan 5.

title: Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time—A RE-LY trial analysis

ReferenceCitation: Hijazi Z, Oldgren J, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Yusuf S, Granger CB, Siegbahn A, Wallentin L; ARISTOTLE and RE-LY Investigators. A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score. Eur Heart J. 2018 Feb 7;39(6):477-485. doi: 10.1093/eurheartj/ehx584.

name: Boston University Medical Center, Boston, MA, USA

title: A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score

ReferenceCitation: Verdecchia P, Reboldi G, Angeli F, Mazzotta G, Lip GYH, Brueckmann M, Kleine E, Wallentin L, Ezekowitz MD, Yusuf S, Connolly SJ, Di Pasquale G. Dabigatran vs. warfarin in relation to the presence of left ventricular hypertrophy in patients with atrial fibrillation- the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) study. Europace. 2018 Feb 1;20(2):253-262. doi: 10.1093/europace/eux022.

name: Department of Medicine, Hospital of Assisi, Assisi, Italy

name: Department of Medicine, University of Perugia, Perugia, Italy

name: Department of Cardiology and Cardiovascular Pathophysiology, Hospital S.M. della Misericordia, Perugia, Italy

name: University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK

name: Boehringer Ingelheim GmbH & Co, Ingelheim am Rhein, Germany

name: Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany

name: Sidney Kimmel Medical College at Jefferson University, Philadelphia, PA, USA

name: Medical College and Lankenau Medical Center, Wynnewood, PA, USA

name: McMaster University, Hamilton, Ontario, Canada

name: Department of Cardiology, Maggiore Hospital, Bologna, Italy

title: Dabigatran vs. warfarin in relation to the presence of left ventricular hypertrophy in patients with atrial fibrillation— the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) study

ReferenceCitation: Lauw MN, Eikelboom JW, Coppens M, Wallentin L, Yusuf S, Ezekowitz M, Oldgren J, Nakamya J, Wang J, Connolly SJ. Effects of dabigatran according to age in atrial fibrillation. Heart. 2017 Jul;103(13):1015-1023. doi: 10.1136/heartjnl-2016-310358. Epub 2017 Feb 17.

title: Effects of dabigatran according to age in atrial fibrillation

ReferenceCitation: Oldgren J, Hijazi Z, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Wallentin L; RE-LY and ARISTOTLE Investigators. Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation. Circulation. 2016 Nov 29;134(22):1697-1707. Epub 2016 Aug 28.

ReferenceCitation: Ezekowitz MD, Nagarakanti R, Noack H, Brueckmann M, Litherland C, Jacobs M, Clemens A, Reilly PA, Connolly SJ, Yusuf S, Wallentin L. Comparison of Dabigatran and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulant Therapy). Circulation. 2016 Aug 23;134(8):589-98. doi: 10.1161/CIRCULATIONAHA.115.020950. Epub 2016 Aug 5.

name: From Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA (M.D.E.); Cardiovascular Research Foundation, New York, NY (M.D.E., C.L.); Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ (R.N.); Electrophysiology Research Foundation, Warren, NJ (R.N.); Boehringer Ingelheim GmbH & Co, Ingelheim am Rhein, Germany (H.N., M.B.); Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany (M.B.); Albert Einstein College of Medicine, New York, NY (M.J.);...

title: Comparison of Dabigatran and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease

ReferenceCitation: Hijazi Z, Oldgren J, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Granger CB, Wallentin L; ARISTOTLE and RE-LY Investigators. The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study. Lancet. 2016 Jun 4;387(10035):2302-2311. doi: 10.1016/S0140-6736(16)00741-8. Epub 2016 Apr 4.

title: The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study

ReferenceCitation: Siegbahn A, Oldgren J, Andersson U, Ezekowitz MD, Reilly PA, Connolly SJ, Yusuf S, Wallentin L, Eikelboom JW. D-dimer and factor VIIa in atrial fibrillation - prognostic values for cardiovascular events and effects of anticoagulation therapy. A RE-LY substudy. Thromb Haemost. 2016 May 2;115(5):921-30. doi: 10.1160/TH15-07-0529. Epub 2016 Jan 28.

title: D-dimer and factor VIIa in atrial fibrillation – prognostic values for cardiovascular events and effects of anticoagulation therapy

ReferenceCitation: Aulin J, Siegbahn A, Hijazi Z, Ezekowitz MD, Andersson U, Connolly SJ, Huber K, Reilly PA, Wallentin L, Oldgren J. Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation. Am Heart J. 2015 Dec;170(6):1151-60. doi: 10.1016/j.ahj.2015.09.018. Epub 2015 Oct 3.

title: Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation

ReferenceCitation: Brambatti M, Darius H, Oldgren J, Clemens A, Noack HH, Brueckmann M, Yusuf S, Wallentin L, Ezekowitz MD, Connolly SJ, Healey JS. Comparison of dabigatran versus warfarin in diabetic patients with atrial fibrillation: Results from the RE-LY trial. Int J Cardiol. 2015 Oct 1;196:127-31. doi: 10.1016/j.ijcard.2015.05.141. Epub 2015 May 28.

title: Comparison of dabigatran versus warfarin in diabetic patients with atrial fibrillation: Results from the RE-LY trial

ReferenceCitation: Böhm M, Ezekowitz MD, Connolly SJ, Eikelboom JW, Hohnloser SH, Reilly PA, Schumacher H, Brueckmann M, Schirmer SH, Kratz MT, Yusuf S, Diener HC, Hijazi Z, Wallentin L. Changes in Renal Function in Patients With Atrial Fibrillation: An Analysis From the RE-LY Trial. J Am Coll Cardiol. 2015 Jun 16;65(23):2481-93. doi: 10.1016/j.jacc.2015.03.577.

title: Changes in Renal Function in Patients With Atrial Fibrillation

ReferenceCitation: Hijazi Z, Oldgren J, Andersson U, Connolly SJ, Ezekowitz MD, Hohnloser SH, Reilly PA, Siegbahn A, Yusuf S, Wallentin L. Importance of persistent elevation of cardiac biomarkers in atrial fibrillation: a RE-LY substudy. Heart. 2014 Aug;100(15):1193-200. doi: 10.1136/heartjnl-2013-304872. Epub 2014 May 2.

title: Importance of persistent elevation of cardiac biomarkers in atrial fibrillation: a RE-LY substudy

ReferenceCitation: Verdecchia P, Reboldi G, Di Pasquale G, Mazzotta G, Ambrosio G, Yang S, Pogue J, Wallentin L, Ezekowitz MD, Connolly SJ, Yusuf S; RE-LY Study Investigators. Prognostic usefulness of left ventricular hypertrophy by electrocardiography in patients with atrial fibrillation (from the Randomized Evaluation of Long-Term Anticoagulant Therapy Study). Am J Cardiol. 2014 Feb 15;113(4):669-75. doi: 10.1016/j.amjcard.2013.10.045. Epub 2013 Nov 23.

title: Prognostic Usefulness of Left Ventricular Hypertrophy by Electrocardiography in Patients With Atrial Fibrillation (from the Randomized Evaluation of Long-Term Anticoagulant Therapy Study)

ReferenceCitation: Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, Ezekowitz MD, Reilly PA, Siegbahn A, Yusuf S, Wallentin L. Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial analysis. Circulation. 2014 Mar 4;129(9):961-70. doi: 10.1161/CIRCULATIONAHA.113.003628. Epub 2013 Dec 9.

name: From Uppsala Clinical Research Center (Z.H., J.O., U.A., A.S., L.W.), Department of Medical Sciences, Cardiology (Z.H., J.O., L.W.), and Department of Medical Sciences, Clinical Chemistry (A.S.), Uppsala University, Sweden; Department of Cardiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Population Health Research Institute, Hamilton, Ontario, Canada (S.J.C., J.W.E., S.Y.); Thomas Jefferson Medical College and the Heart Center, Wynnewood, PA (M.D.E.); and Boehringer Ingelheim...

title: Efficacy and Safety of Dabigatran Compared With Warfarin in Relation to Baseline Renal Function in Patients With Atrial Fibrillation

ReferenceCitation: Majeed A, Hwang HG, Connolly SJ, Eikelboom JW, Ezekowitz MD, Wallentin L, Brueckmann M, Fraessdorf M, Yusuf S, Schulman S. Management and outcomes of major bleeding during treatment with dabigatran or warfarin. Circulation. 2013 Nov 19;128(21):2325-32. doi: 10.1161/CIRCULATIONAHA.113.002332. Epub 2013 Sep 30.

name: From the Coagulation Unit, Hematology Center, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden (A.M., S.S.); the Department of Medicine, Soonchunhyang University Gumi’s Hospital, North Kyungsang Province, South Korea (H.-G-H.); McMaster University, Population Health Research Institute, Hamilton, ON, Canada (S.J.C., J.W.E., S.Y.); Lankenau Medical Center, Thomas Jefferson Medical College, Wynnewood, PA (M.D.E.); Uppsala Clinical Research Center and Department of Medical...

title: Management and Outcomes of Major Bleeding During Treatment With Dabigatran or Warfarin

ReferenceCitation: Reilly PA, Lehr T, Haertter S, Connolly SJ, Yusuf S, Eikelboom JW, Ezekowitz MD, Nehmiz G, Wang S, Wallentin L; RE-LY Investigators. The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy). J Am Coll Cardiol. 2014 Feb 4;63(4):321-8. doi: 10.1016/j.jacc.2013.07.104. Epub 2013 Sep 27.

title: The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients

ReferenceCitation: Marijon E, Le Heuzey JY, Connolly S, Yang S, Pogue J, Brueckmann M, Eikelboom J, Themeles E, Ezekowitz M, Wallentin L, Yusuf S; RE-LY Investigators. Causes of death and influencing factors in patients with atrial fibrillation: a competing-risk analysis from the randomized evaluation of long-term anticoagulant therapy study. Circulation. 2013 Nov 12;128(20):2192-201. doi: 10.1161/CIRCULATIONAHA.112.000491. Epub 2013 Sep 9.

name: From the Paris Cardiovascular Research Center, Paris, France (E.M.); Paris Descartes University, Paris, France (E.M., J.-Y.L.H.); European Georges Pompidou Hospital, Paris, France (E.M., J.-Y.L.H.); Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, ON, Canada (S.C., S.Y., J.P., J.E., E.T., S.Y.); Boehringer Ingelheim Pharma GmbH & Co KG, Clinical Development and Medical Affairs, Ingelheim am Rhein, Germany, and Medical Faculty Mannheim of the...

title: Causes of Death and Influencing Factors in Patients With Atrial Fibrillation

ReferenceCitation: Eikelboom JW, Connolly SJ, Hart RG, Wallentin L, Reilly P, Oldgren J, Yang S, Yusuf S. Balancing the benefits and risks of 2 doses of dabigatran compared with warfarin in atrial fibrillation. J Am Coll Cardiol. 2013 Sep 3;62(10):900-8. doi: 10.1016/j.jacc.2013.05.042. Epub 2013 Jun 13.

title: Balancing the Benefits and Risks of 2 Doses of Dabigatran Compared With Warfarin in Atrial Fibrillation

ReferenceCitation: Hori M, Connolly SJ, Zhu J, Liu LS, Lau CP, Pais P, Xavier D, Kim SS, Omar R, Dans AL, Tan RS, Chen JH, Tanomsup S, Watanabe M, Koyanagi M, Ezekowitz MD, Reilly PA, Wallentin L, Yusuf S; RE-LY Investigators. Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation. Stroke. 2013 Jul;44(7):1891-6. doi: 10.1161/STROKEAHA.113.000990. Epub 2013 Jun 6.

name: From the Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan (M.H.); Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.J.C., S.Y.); Cardiovascular Institute & Fu Wai Hospital, Beijing, China (J.Z., L.S.L.); Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong (C.-P.L.); St. John’s Medical College and Research Institute, Bangalore, India (P.P., D.X.); Yonsei University College of Medicine, Seoul,...

title: Dabigatran Versus Warfarin

ReferenceCitation: Paré G, Eriksson N, Lehr T, Connolly S, Eikelboom J, Ezekowitz MD, Axelsson T, Haertter S, Oldgren J, Reilly P, Siegbahn A, Syvanen AC, Wadelius C, Wadelius M, Zimdahl-Gelling H, Yusuf S, Wallentin L. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation. 2013 Apr 2;127(13):1404-12. doi: 10.1161/CIRCULATIONAHA.112.001233. Epub 2013 Mar 6.

name: From the Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada (G.P., S.C., J.E., S.Y.); Uppsala Clinical Research Center and Department of Medical Sciences (N.E., J.O., L.W.), Department of Medical Sciences (T.A., A.S., A.-C.S., M.W.), and Department of Immunology, Genetics and Pathology, Science for Life Laboratory (C.W.), Uppsala University, Uppsala, Sweden; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany (T.L., S.H., H.Z.-G....

title: Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

ReferenceCitation: Dans AL, Connolly SJ, Wallentin L, Yang S, Nakamya J, Brueckmann M, Ezekowitz M, Oldgren J, Eikelboom JW, Reilly PA, Yusuf S. Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial. Circulation. 2013 Feb 5;127(5):634-40. doi: 10.1161/CIRCULATIONAHA.112.115386. Epub 2012 Dec 27.

name: From College of Medicine, University of the Philippines Manila, Philippines (A.L.D.); Population Health Research Institute, McMaster University, Ontario, Canada (S.J.C., S. Yang, J.N., J.W.E, S. Yusuf); Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (L.W.); Boehringer Ingelheim GmbH & Co. KG, Ingelheim, Germany (M.B.); Jefferson Medical College, Wynnewood, PA and Cardiovascular Research Foundation, New York, NY (M.E.); Uppsala...

title: Concomitant Use of Antiplatelet Therapy with Dabigatran or Warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Trial

ReferenceCitation: Bytzer P, Connolly SJ, Yang S, Ezekowitz M, Formella S, Reilly PA, Aisenberg J. Analysis of upper gastrointestinal adverse events among patients given dabigatran in the RE-LY trial. Clin Gastroenterol Hepatol. 2013 Mar;11(3):246-52.e1-5. doi: 10.1016/j.cgh.2012.10.021. Epub 2012 Oct 24.

journal_name: Clinical Gastroenterology and Hepatology

title: Analysis of Upper Gastrointestinal Adverse Events Among Patients Given Dabigatran in the RE-LY Trial

ReferenceCitation: Van Spall HG, Wallentin L, Yusuf S, Eikelboom JW, Nieuwlaat R, Yang S, Kabali C, Reilly PA, Ezekowitz MD, Connolly SJ. Variation in warfarin dose adjustment practice is responsible for differences in the quality of anticoagulation control between centers and countries: an analysis of patients receiving warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial. Circulation. 2012 Nov 6;126(19):2309-16. doi: 10.1161/CIRCULATIONAHA.112.101808. Epub 2012 Oct 1.

name: From the Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, ON, Canada (H.G.C.V., S.Y., J.W.E., R.N., S.Y., C.K., S.J.C.); Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (L.W.); Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT (P.A.R.); and Lankenau Institute for Medical Research and the Heart Center, Wynnewood, PA (M.D.E.).

title: Variation in Warfarin Dose Adjustment Practice Is Responsible for Differences in the Quality of Anticoagulation Control Between Centers and Countries

ReferenceCitation: Healey JS, Eikelboom J, Douketis J, Wallentin L, Oldgren J, Yang S, Themeles E, Heidbuchel H, Avezum A, Reilly P, Connolly SJ, Yusuf S, Ezekowitz M; RE-LY Investigators. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial. Circulation. 2012 Jul 17;126(3):343-8. doi: 10.1161/CIRCULATIONAHA.111.090464. Epub 2012 Jun 14. Erratum in: Circulation. 2012 Sep 4;126(10):e160. Heidbuchle, Hein [corrected to Heidbuchel, Hein].

name: From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., J.E., S.Y., E.T., S.J.C., S.Y.); St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, Canada (J.D.); Uppsala Clinical Research Centre, Uppsala, Sweden (L.W., J.O.); University Hospitals Leuven, University of Leuven, Leuven, Belgium (H.H.); Instituto Dante Pazzenese de Cardiologia, Hospital Do Coracao, Sao Paolo, Brazil (A.A.); Boehringer-Ingelheim Pharmaceuticals, Ridgefield, CT (P.R.); and...

title: Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin

ReferenceCitation: Hijazi Z, Oldgren J, Andersson U, Connolly SJ, Ezekowitz MD, Hohnloser SH, Reilly PA, Vinereanu D, Siegbahn A, Yusuf S, Wallentin L. Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy. Circulation. 2012 Apr 3;125(13):1605-16. doi: 10.1161/CIRCULATIONAHA.111.038729. Epub 2012 Feb 28.

name: From the Uppsala Clinical Research Center and Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden (Z.H., J.O., L.W.); Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (U.A.); Population Health Research Institute, Hamilton, Canada (S.J.C., S.Y.); Lankenau Institute for Medical Research and the Heart Center, Wynnewood, PA (M.D.E.); Department of Cardiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Boehringer Ingelheim Pharmaceuticals,...

title: Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation

ReferenceCitation: Hohnloser SH, Oldgren J, Yang S, Wallentin L, Ezekowitz M, Reilly P, Eikelboom J, Brueckmann M, Yusuf S, Connolly SJ. Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial. Circulation. 2012 Feb 7;125(5):669-76. doi: 10.1161/CIRCULATIONAHA.111.055970. Epub 2012 Jan 3.

name: From the Department of Cardiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, Uppsala, Sweden (J.O., L.W.); McMaster University, Population Health Research Institute, Hamilton, Ontario, Canada (S. Yang, J.E., S. Yusuf, S.J.C.); Lankenau Medical Center, Thomas Jefferson Medical College, Wynnewood, PA (M.E.); Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT (P.R.); and Boehringer Ingelheim Pharma...

title: Myocardial Ischemic Events in Patients With Atrial Fibrillation Treated With Dabigatran or Warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial

ReferenceCitation: Oldgren J, Alings M, Darius H, Diener HC, Eikelboom J, Ezekowitz MD, Kamensky G, Reilly PA, Yang S, Yusuf S, Wallentin L, Connolly SJ; RE-LY Investigators. Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial. Ann Intern Med. 2011 Nov 15;155(10):660-7, W204. doi: 10.7326/0003-4819-155-10-201111150-00004.

title: Risks for Stroke, Bleeding, and Death in Patients With Atrial Fibrillation Receiving Dabigatran or Warfarin in Relation to the CHADS_2 Score: A Subgroup Analysis of the RE-LY Trial

ReferenceCitation: Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J, Yang S, Alings M, Kaatz S, Hohnloser SH, Diener HC, Franzosi MG, Huber K, Reilly P, Varrone J, Yusuf S. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation. 2011 May 31;123(21):2363-72. doi: 10.1161/CIRCULATIONAHA.110.004747. Epub 2011 May 16.

name: From the Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada (J.W.E., S.J.C., J.S.H., S.Y.); Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden (L.W., J.O.); Lankenau Institute for Medical Research and The Heart Center, Wynnewood, PA (M.E.); Working Group Cardiovascular Research, Utrecht, Netherlands (M.A.); Henry Ford Hospital, Detroit, MI (S.K.); Department of Cardiology, J.W. Goethe University, Frankfurt, Germany (S...

title: Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation

ReferenceCitation: Nagarakanti R, Ezekowitz MD, Oldgren J, Yang S, Chernick M, Aikens TH, Flaker G, Brugada J, Kamensky G, Parekh A, Reilly PA, Yusuf S, Connolly SJ. Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion. Circulation. 2011 Jan 18;123(2):131-6. doi: 10.1161/CIRCULATIONAHA.110.977546. Epub 2011 Jan 3.

name: From the Louisiana State University School of Medicine, New Orleans (R.N.); Lankenau Institute for Medical Research and The Heart Center, Wynnewood, PA (M.D.E., M.C., T.H.A., A.P.); Uppsala Clinical Research Centre and Department of Medical Sciences, Uppsala University, Uppsala, Sweden (J.O.); Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.Y., S.Y., S.J.C.); University of Missouri Hospital, Columbia (G.F.); Hospital Clinic, University...

evidence: oa repository (via OAI-PMH title and last author match)

repository_institution: University of Melbourne - Minerva Access

repository_normalized: University of Melbourne - Minerva Access

repository_institution: The University of Queensland - Queensland's institutional digital repository

repositories: University of Melbourne - Minerva Access

repositories_institution: The University of Queensland - Queensland's institutional digital repository

repositories_institution: University of Melbourne - Minerva Access

title: Dabigatran Versus Warfarin in Patients With Atrial Fibrillation

ReferenceCitation: Ezekowitz MD, Wallentin L, Connolly SJ, Parekh A, Chernick MR, Pogue J, Aikens TH, Yang S, Reilly PA, Lip GY, Yusuf S; RE-LY Steering Committee and Investigators. Dabigatran and warfarin in vitamin K antagonist-naive and -experienced cohorts with atrial fibrillation. Circulation. 2010 Nov 30;122(22):2246-53. doi: 10.1161/CIRCULATIONAHA.110.973735.

name: From the Lankenau Institute for Medical Research and The Heart Center, Wynnewood, Pa (M.D.E., A.P., M.R.C., T.H.A.); Uppsala Clinical Research Centre and Department of Medical Sciences, Uppsala University, Uppsala, Sweden (L.W.); Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada (S.J.C., J.P., S. Yang, S. Yusuf); Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn (P.A.R.); and University of Birmingham Centre for Cardiovascular...

name: the RE-LY Steering Committee and Investigators

title: Dabigatran and Warfarin in Vitamin K Antagonist–Naive and –Experienced Cohorts With Atrial Fibrillation

ReferenceCitation: Diener HC, Connolly SJ, Ezekowitz MD, Wallentin L, Reilly PA, Yang S, Xavier D, Di Pasquale G, Yusuf S; RE-LY study group. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol. 2010 Dec;9(12):1157-1163. doi: 10.1016/S1474-4422(10)70274-X. Epub 2010 Nov 6. Erratum in: Lancet Neurol. 2011 Jan;10(1):27.

title: Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial

ReferenceCitation: Wallentin L, Yusuf S, Ezekowitz MD, Alings M, Flather M, Franzosi MG, Pais P, Dans A, Eikelboom J, Oldgren J, Pogue J, Reilly PA, Yang S, Connolly SJ; RE-LY investigators. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet. 2010 Sep 18;376(9745):975-83. doi: 10.1016/S0140-6736(10)61194-4.

ReferenceCitation: Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139-51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30. Erratum in: N Engl J Med. 2010 Nov 4;363(19):1877.

repository_institution: University of Western Australia - UWA Profiles and Research Repository

repositories_institution: University of Western Australia - UWA Profiles and Research Repository

title: Dabigatran versus Warfarin in Patients with Atrial Fibrillation

ReferenceCitation: Ezekowitz MD, Connolly S, Parekh A, Reilly PA, Varrone J, Wang S, Oldgren J, Themeles E, Wallentin L, Yusuf S. Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. Am Heart J. 2009 May;157(5):805-10, 810.e1-2. doi: 10.1016/j.ahj.2009.02.005.

title: Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran

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location_facility: 1160.26.1629 AVK-mott, Spec.M1, Länssjukhuset Ryhov

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location_facility: 1160.26.1627 Hjärtmott. ING 35, Malmö Universitetssjukhus MAS

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location_facility: 1160.26.1451 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.550653 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0880F Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0502 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.550651 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1096 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0353 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1673 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0708 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1297 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1502 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0872C Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0957 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1242 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0966 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0402 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1454 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0304 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.0858 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0819 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1163 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1512 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0055 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1582 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0237 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1506 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0148 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1168 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0510 Boehringer Ingelheim Investigational Site

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location_facility: 1160.26.1453 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0411 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1332 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0025 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0874A Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0013 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0724 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1192 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0465 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0679 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0138 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0962 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0084 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0166 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0577 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0696 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0879E Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0430 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.1234 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0294 Boehringer Ingelheim Investigational Site

location_facility: 1160.26.0873A Boehringer Ingelheim Investigational Site