title: A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

summary: This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

location_facility: Hamilton Health Sciences - McMaster University Medical Centre /ID# 150477

location_facility: South Denver Gastroenterology /ID# 151224

location_facility: Kazan State Medical University /ID# 166040

location_facility: CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 216302

location_facility: University Clinical Centre of the Republic of Srpska /ID# 150223

location_facility: Agaplesion Markus Krankenhaus /ID# 161870

location_facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 151618

location_facility: Niigata University Medical & Dental Hospital /ID# 218050

location_facility: Encore Borland-Groover Clinical Research /Id# 170913

location_facility: Sapporo Higashi Tokushukai Hospital /ID# 208495

location_facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673

location_facility: Duplicate_Klinicki bolnicki centar Osijek /ID# 150229

location_facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334

location_facility: University of Maryland Med Ctr /ID# 150529

location_facility: St.Luke's International Hospital /ID# 208075

location_facility: National Hospital Organization Sendai Medical Center /ID# 209529

location_facility: The First Affiliated Hospital of Nanchang University /ID# 212185

location_facility: Clin Res Inst of Michigan, LLC /ID# 153031

location_facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 152492

location_facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726

location_facility: University Clinical Center Kragujevac /ID# 150644

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101

location_facility: Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516

location_facility: Umraniye Training and Res Hosp /ID# 163136

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 213541

location_facility: St Vincent's University Hospital /ID# 150411

location_facility: Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 151615

location_facility: Ctr for Gastrointestinal Healt /ID# 153369

location_facility: Next Innovative Clinical Research - Chicago /ID# 217323

location_facility: Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606

location_facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 217659

location_facility: Washington University-School of Medicine /ID# 150537

location_facility: Yamanashi Prefectural Central Hospital /ID# 151909

location_facility: Percuro Clinical Research, Ltd /ID# 150479

location_facility: Klinicka bolnica Dubrava Zagreb /ID# 150228

location_facility: Shanghai Tenth People's Hospital /ID# 150522

location_facility: CHU Montpellier - Hôpital Saint Eloi /ID# 200088

location_facility: Hospital Britanico de Buenos Aires /ID# 209496

location_facility: Hospital Universitario de San /ID# 155388

location_facility: Markusovszky Egyetemi Oktatokorhaz /ID# 150410

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 211169

location_facility: University Clinical Center Tuzla /ID# 150224

location_facility: ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605

location_facility: West China Hospital, Sichuan University /ID# 167041

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 152609

location_facility: Leids Universitair Medisch Centrum /ID# 152625

location_facility: Moonshine Research Center, Inc /ID# 152534

location_facility: Toho University Sakura Medical Center /ID# 151935

location_facility: Montefiore Medical Center - Moses Campus /ID# 150559

location_facility: Shoyukai Fujita Gastroenterological Hospital /ID# 216494

location_facility: Akershus Universitetssykehus_MAIN /ID# 150622

location_facility: NYU Langone Long Island Clinical Research Association /ID# 155271

location_facility: Medizinisches Versorgungszentrum Portal 10 /ID# 207136

location_facility: Kitakyushu Municipal Medical Center /ID# 152589

location_facility: DiGiovanna Institute for Medical Education & Research /ID# 201534

location_facility: University General Hospital of Ioannina /ID# 164247

location_facility: Advanced Research Institute, Inc /ID# 163093

location_facility: TX Clinical Research Institute /ID# 151528

location_facility: Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820

location_facility: Theageneio Anticancer Hospital /ID# 164187

location_facility: Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731

location_facility: Hiroshima University Hospital /ID# 151952

location_facility: Yonsei University Health System Severance Hospital /ID# 161566

location_facility: Aurora Medical Center - Grafto /ID# 151726

location_facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 150463

location_facility: Private Practice Dr MN Rajabally /ID# 155145

location_facility: China Medical University Hospital /ID# 150600

location_facility: Toyohashi Municipal Hospital /ID# 171470

location_facility: CliniCore International, LLC /ID# 152078

location_facility: Klinicki bolnicki centar Zagreb /ID# 150715

location_facility: Erciyes University Medical Fac /ID# 150495

location_facility: The University of Chicago DCAM /ID# 150564

location_facility: Pusan National University Hospital /ID# 161569

location_facility: Centex Studies, Inc. - Houston /ID# 201217

location_facility: University Clinical Hospital Mostar /ID# 150711

location_facility: Asahikawa Medical University Hospital /ID# 170281

location_facility: Royal Devon University Healthcare NHS Foundation Trust /ID# 150510

location_facility: The First Hospital of Jilin University /ID# 210087

location_facility: Radboud Universitair Medisch Centrum /ID# 151701

location_facility: The First Affiliated Hospital, Sun Yat-sen University /ID# 150517

location_facility: Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407

location_facility: Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 150946

location_facility: Klaipeda university hospital /ID# 163501

location_facility: Universitair Medisch Centrum Utrecht /ID# 152776

location_facility: East Tallinn Central Hospital /ID# 150488

location_facility: CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374

location_facility: Sapporo Medical University Hospital /ID# 206493

location_facility: Dartmouth-Hitchcock Medical Center /ID# 150566

location_facility: Atlantic Digestive Health Inst /ID# 150527

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439

location_facility: Inselspital, Universitätsspital Bern /ID# 152602

location_facility: Osaka Metropolitan University Hospital /ID# 152681

location_facility: Ottawa Hospital Research Institute /ID# 151817

location_facility: Universal Axon Clinical Research /ID# 213463

location_facility: West Tallinn Central Hospital /ID# 150490

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 212425

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 150640

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406

location_facility: Klinicki bolnicki centar Rijeka /ID# 150714

location_facility: Hospital Universitario Dr. Negrin /ID# 203965

location_facility: Bekes Megyei Kozponti Korhaz /ID# 151601

location_facility: University of Iowa Hospitals and Clinics /ID# 157059

location_facility: Hospital Garcia de Orta, EPE /ID# 151622

location_facility: Wake Forest Baptist Medical Center /ID# 150528

location_facility: Medical Center of the "Health /ID# 162501

location_facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 150424

location_facility: Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 150236

location_facility: Slovak Research Center Team Me /ID# 150240

location_facility: Indianapolis Gastroenterology /ID# 162914

location_facility: Clinical Center University of Sarajevo /ID# 150222

location_facility: Yamagata University Hospital /ID# 171468

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 150557

location_facility: Fukuoka University Chikushi Hospital /ID# 152627

location_facility: Hospital Universitario y Politecnico La Fe /ID# 150591

location_facility: University Hospitals Birmingham NHS Foundation Trust /ID# 150513

location_facility: Immanuel Kant Baltic Federal University /ID# 202129

location_facility: Universitetssykehuset Nord-Norge /ID# 152836

location_facility: Macquarie University Hospital /ID# 211953

location_facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204777

location_facility: Options Health Research, LLC /ID# 150569

location_facility: Medical Research Center of CT /ID# 150534

location_facility: Taipei Veterans General Hosp /ID# 151750

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 150421

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812

location_facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634

location_facility: The Sixth Affiliated Hosp Sun /ID# 150518

location_facility: Massachusetts General Hospital /ID# 165678

location_facility: Nature Coast Clinical Research - Inverness /ID# 154070

location_facility: Houma Digestive Health Special /ID# 151851

location_facility: Aichi Medical University Hospital /ID# 151994

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 171492

location_facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 217219

location_facility: Velocity Clinical Research - Salt Lake City /ID# 163180

location_facility: Duplicate_Stavropol State Medical Univ /ID# 150635

location_facility: Louisiana Research Center, LLC /ID# 150526

location_facility: Juntendo University Urayasu Hospital /ID# 208783

location_facility: Universitaetsklinikum Muenster /ID# 150402

location_facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616

location_facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 167954

location_facility: Premier Medical Group - GI Division /ID# 153366

location_facility: Kyiv City Clinical Hospital No.18 /ID# 150505

location_facility: Iwate Medical University Uchimaru Medical Center /ID# 203412

location_facility: Yokkaichi Hazu Medical Center /ID# 214349

location_facility: Shengjing Hospital of China Medical University /ID# 166921

location_facility: Clin Res Inst of Michigan, LLC /ID# 161983

location_facility: Toronto Digestive Disease Associates, Inc. /ID# 150475

location_facility: Mentahaz Maganorvosi Kozpont /ID# 206977

location_facility: Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502

location_facility: Vanderbilt University Medical Center /ID# 153364

location_facility: Hospital Clinico Universidad De Los Andes /ID# 207427

location_facility: Kitano Hospital, Tazuke Kofukai Medical Research Institute /ID# 210396

location_facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 150263

location_facility: Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599

location_facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523

location_facility: Gazi Universitesi Tip Fakultes /ID# 150493

location_facility: Hadassah Medical Center-Hebrew University /ID# 165119

location_facility: Nagoya City University Hospital /ID# 151949

location_facility: Hospital Universitario de Salamanca /ID# 150590

location_facility: Hamamatsu University Hospital /ID# 205709

location_facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744

location_facility: Baylor College of Medicine - Baylor Medical Center /ID# 150538

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 165813

location_facility: Center Hospital of the National Center for Global Health and Medicine /ID# 209533

location_facility: MediSphere Medical Research Center /ID# 152080

location_facility: Faculdade de Medicina do ABC /ID# 152489

location_facility: CHU de Saint-Etienne, Hopital Nord /ID# 165756

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705

location_facility: The Catholic University of Korea, ST. Vincent's Hospital /ID# 150434

location_facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823

location_facility: Hyogo Medical University Hospital /ID# 152433

location_facility: Digestive Health Partners, P.A /ID# 167238

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079

location_facility: University Clinical Center of Nis /ID# 151902

location_facility: Coorp Hosp Juan Ciudad Sede Hospital Universitario Mayor Mederi /ID# 152811

location_facility: East Tennessee Research Institute /ID# 203611

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 151362

location_facility: Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167170

location_facility: Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630

location_facility: Tyler Research Institute, LLC /ID# 169147

location_facility: General Hospital of Thessaloniki Hippokrateio /ID# 209522

location_facility: NHS Greater Glasgow and Clyde /ID# 163788

location_facility: Chu de Nice-Hopital L'Archet Ii /Id# 152608

location_facility: Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491

location_facility: Caprock Gastro Research, LLC /ID# 215116

location_facility: Hospital Universitario La Paz /ID# 214541

location_facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733

location_facility: Carl R. Meisner Medical Clinic /ID# 171270

location_facility: Digestive Disease Specialists /ID# 201057

location_facility: Ishida Clinic of IBD and Gastroenterology /ID# 210118

location_facility: Duplicate_CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150473

location_facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420

location_facility: Yeungnam University Medical Center /ID# 150432

location_facility: Yokohama City University Medical Center /ID# 169900

location_facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313

location_facility: Clinical Hosp Center Zvezdara /ID# 150641

location_facility: Atrium Health Carolinas Medical Center /ID# 157060

location_facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224

location_facility: Republican hospital named after V.A. Baranov /ID# 206508

location_facility: National Hospital Organization Hirosaki General Medical Center /ID# 152761

location_facility: Gastro Health & Nutrition - Victoria /ID# 167764

location_facility: United Medical Doctors - Murrieta /ID# 151213

location_facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 150425

location_facility: Inland Empire Clinical Trials, LLC /ID# 216163

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158

location_facility: Huron Gastroenterology Assoc /ID# 152712

location_facility: Hospital Universitario Ramon y Cajal /ID# 171491

location_facility: Lviv Regional Clinical Hospital /ID# 150508

location_facility: Hometown Urgent Care and Resea /ID# 200066

location_facility: Universitatsklinikum Mannheim /ID# 150405

location_facility: Cooper Gastroenterology at Fire Road /ID# 153048

location_facility: University of Alberta - Zeidler Ledcor Centre /ID# 151824

location_facility: General Hospital of Athens Laiko /ID# 208672

location_facility: Kanazawa University Hospital /ID# 207810

location_facility: Kaiser Clinica e Hospital Dia /ID# 152491

location_facility: Hospital Unversitario Marques de Valdecilla /ID# 216621

location_facility: Centro Hospitalar de Entre Douro e Vouga /ID# 152336

location_facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 170713

location_facility: Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183

location_facility: St George's University Hospitals NHS Foundation Trust /ID# 208376

location_facility: Medical Center CONSILIUM MEDICAL /ID# 217448

location_facility: Lenasia Clinical Trial Centre /ID# 214361

location_facility: Crystal Pharmacology Research /ID# 151848

location_facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629

location_facility: NorthShore University HealthSystem /ID# 150570

location_facility: Sahlgrenska University Hospital /ID# 152326

location_facility: Montreal General Hospital - McGill University Health Centre /ID# 170013

location_facility: Newport Huntington Medical Group /ID# 217006

location_facility: Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151845

location_facility: Hospital Privado Univesitario /ID# 164186

location_facility: East View Medical Research, LLC /ID# 171184

location_facility: Morales Vargas Centro de Investigacion S.C. /ID# 211327

location_facility: Northwest Health Care Associates /ID# 151591

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871

location_facility: Atlantic Gastroenterology Clinical Research /ID# 151901

location_facility: Medizinische Universitaet Wien /ID# 150616

location_facility: University of Mississippi Medical Center /ID# 213140

location_facility: Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265

location_facility: Gastoenterology Group of Rochester /ID# 151080

location_facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462

location_facility: Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399

location_facility: Mautalen Salud e Investigacion /ID# 171174

location_facility: Tokyo Women's Medical University Hospital /ID# 205978

location_facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487

location_facility: Tianjin Medical University General Hospital /ID# 170605

location_facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 151620

location_facility: Pauls Stradins Clinical University Hospital /ID# 153183

location_facility: Japanese Red Cross Osaka Hospital /ID# 209477

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826

location_facility: Hospital Universitario A Coruna - CHUAC /ID# 203912

location_facility: Clinical Research Trials of Florida, Inc. /ID# 201791

location_facility: National Taiwan University Hospital /ID# 150604

location_facility: Kitasato University Kitasato Institute Hospital /ID# 152687

location_facility: North Estonia Medical Centre /ID# 160871

location_facility: National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711

location_facility: Southern Star Research Institute, LLC /ID# 169397

location_facility: St Vincent's Hospital Melbourne /ID# 152503

location_facility: National University Hospital /ID# 150583

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 165783

location_facility: Hospital Nossa Senhora das Graças /ID# 152488

location_facility: Tsujinaka Hospital Kashiwanoha /ID# 209572

location_facility: CHA University Bundang Medical Center /ID# 161567

location_facility: West Central Gastroenterology /ID# 155242

location_facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082

location_facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697

location_facility: National Cheng Kung University Hospital /ID# 151751

location_facility: Klinicki bolnicki centar Zagreb /ID# 150262

location_facility: Xiangya Hospital Central South University /ID# 167230

location_facility: Soroka University Medical Center /ID# 156562

location_facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089

location_facility: Columbia Univ Medical Center /ID# 163409

location_facility: Hampshire Hospitals NHS Foundation Trust /ID# 150511

location_facility: Tokai University Hachioji Hospital /ID# 152584

location_facility: Revival Research Institute, LLC /ID# 207281

location_facility: Chung Shan Medical University Hospital /ID# 150603

location_facility: Dayton Gastroenterology, Inc. /ID# 167632

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 151619

location_facility: Virginia Mason Medical Center /ID# 153030

location_facility: Showa University Fujigaoka Hospital /ID# 208223

location_facility: CB Flock Research Corporation /ID# 165986

location_facility: The Vancouver Clinic, INC. PS /ID# 162334

location_facility: Hospital Universitario Reina Sofia /ID# 154031

location_facility: Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 150627

location_facility: Tokyo Medical And Dental University Hospital /ID# 152017

location_facility: Univ of California San Francis /ID# 164583

location_facility: Great Lakes Gastroenterology Research, LLC /ID# 201773

location_facility: University Clinical Centre of the Republic of Srpska /ID# 150712

location_facility: NW State Medical Univ na Mechn /ID# 169332

location_facility: National Hospital Organization Mito Medical Center /ID# 152626

location_facility: CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 165749

location_facility: Hospital Clinic de Barcelona /ID# 150598

location_facility: Duplicate_Helsinki Univ Central Hospital /ID# 154283

location_facility: InSite Digestive Health Care - Oxnard /ID# 163417

location_facility: Atlanta Gastroenterology Spec /ID# 150565

location_facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771

location_facility: CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941

location_facility: Universitätsklinikum Tübingen /ID# 151698

location_facility: Klaipeda University Hospital /ID# 163719

location_facility: Kagoshima IBD Gastroenterology Clinic /ID# 245222

location_facility: University Clinical Center Serbia /ID# 150642

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869

location_facility: Plains Clinical Research Center, LLC /ID# 170291

location_facility: St. Marianna University Hospital /ID# 209452

location_facility: Minnesota Gastroenterology PA /ID# 151682

location_facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 150226

location_facility: Richmond University Medical Center /ID# 201860

location_facility: Utah Gastroenternology - St. Mark's Office /ID# 163097

location_facility: Ohio Clinical Research Partner /ID# 154074

location_facility: Vitebsk Regional Advanced Clin /ID# 169592

location_facility: Marmara University Medical Fac /ID# 214573

location_facility: Hospital de Clinicas de Porto Alegre /ID# 153745

location_facility: Western Connecticut Medical Group /ID# 169211

location_facility: Hanyang University Gurihospital /ID# 150431

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371

location_facility: Texas Digestive Disease Consultants /ID# 209949

location_facility: Delsol Research Management, Ll /Id# 170130

location_facility: Klinicki bolnicki centar Split /ID# 213989

location_facility: CCA Braga - Hospital de Braga /ID# 151617

location_facility: Healthcare Research Consultant /ID# 163096

location_facility: Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730

location_facility: Saiseikai Fukuoka Genaral Hospital /ID# 209481

location_facility: Medical College of Wisconsin /ID# 151850

location_facility: Northwest Gastroenterology Clinic /ID# 152528

location_facility: Citrus Valley Gastroenterology /ID# 151915

location_facility: Universitair Ziekenhuis Leuven /ID# 150468

location_facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886


title: Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction

acronym: UNTOUCHED

summary: This study assesses the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) for primary prevention of sudden cardiac death. Devices are to be programmed with zone cutoffs at 200 bpm and 250 bmp in order to mimic the programming settings for transvenous ICDs in the MADIT RIT study. The incidence of inappropriate S-ICD shocks will be compared to the incidence of inappropriate shocks observed in the MADIT RIT study.

study_start_date_type: Actual

status: Completed

study_completion_date_type: Actual

study_type: Interventional

primary_purpose: Supportive Care

enrollment_type: Actual

ReferenceType: background

ReferenceCitation: Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, Estes NA 3rd, Greenberg H, Hall WJ, Huang DT, Kautzner J, Klein H, McNitt S, Olshansky B, Shoda M, Wilber D, Zareba W; MADIT-RIT Trial Investigators. Reduction in inappropriate therapy and mortality through ICD programming. N Engl J Med. 2012 Dec 13;367(24):2275-83. doi: 10.1056/NEJMoa1211107. Epub 2012 Nov 6.

ReferenceCitation: Gold MR, Knops R, Burke MC, Lambiase PD, Russo AM, Bongiorni MG, Deharo JC, Aasbo J, El Chami MF, Husby M, Carter N, Boersma L. The Design of the Understanding Outcomes with the S-ICD in Primary Prevention Patients with Low EF Study (UNTOUCHED). Pacing Clin Electrophysiol. 2017 Jan;40(1):1-8. doi: 10.1111/pace.12994. Epub 2017 Jan 15.

ReferenceType: result

ReferenceCitation: Boersma LV, El-Chami MF, Bongiorni MG, Burke MC, Knops RE, Aasbo JD, Lambiase PD, Deharo JC, Russo AM, Dinerman J, Shaik N, Barr CS, Carter N, Appl U, Brisben AJ, Stein KM, Gold MR. Understanding Outcomes with the EMBLEM S-ICD in Primary Prevention Patients with Low EF Study (UNTOUCHED): Clinical characteristics and perioperative results. Heart Rhythm. 2019 Nov;16(11):1636-1644. doi: 10.1016/j.hrthm.2019.04.048. Epub 2019 May 10.

oa_colors: green hybrid

oa_host_type: publisher;repository

evidence: open (via crossref license)

host_type: publisher

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

version: publishedVersion

evidence: oa repository (via OAI-PMH title and first author match)

host_type: repository

repository_institution: University College London - UCL Discovery

repository_normalized: UCL Discovery

repositories_concat: UCL Discovery

unpaywall_oa_status: hybrid

publisher_dissemination: Elsevier

ReferenceCitation: Gold MR, Lambiase PD, El-Chami MF, Knops RE, Aasbo JD, Bongiorni MG, Russo AM, Deharo JC, Burke MC, Dinerman J, Barr CS, Shaik N, Carter N, Stoltz T, Stein KM, Brisben AJ, Boersma LVA; UNTOUCHED Investigators*. Primary Results From the Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction (UNTOUCHED) Trial. Circulation. 2021 Jan 5;143(1):7-17. doi: 10.1161/CIRCULATIONAHA.120.048728. Epub 2020 Oct 19.

evidence: open (via page says license)

evidence: oa repository (via OAI-PMH doi match)

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Inria

repository_normalized: HAL

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Aix-Marseille Université

repository_institution: Le Centre pour la Communication Scientifique Directe - HAL - Université Paris Descartes

license: cc-by

license_normalized: cc-by

repository_institution: University of Illinois at Chicago - INDIGO

evidence: oa repository (via pmcid lookup)

license_normalized: no license

repository_normalized: PubMed Central

repositories:
HAL
PubMed Central
UCL Discovery
figshare.com

publisher_dissemination: Wolters Kluwer Health

ipd_sharing: No

lead_sponsor: Boston Scientific Corporation

location_country:
Germany
Italy
Poland
United Kingdom
Denmark
Netherlands
Switzerland
Belgium
United States
Spain
Canada
Puerto Rico
France

location_facility: Centralny Szpital Kliniczny Uniwerytetu Medycznego

location_facility: Erasmus MC - University Medical Center Rotterdam

location_facility: Azienda Ospedaliero Universitaria Pisana

location_facility: Azienda Ospedaliera Universitaria Integrata di Verona

location_facility: CardioVascular Institute of Michigan P.C.

location_facility: Institut universitaire de Cardiologie et de Pneumologie de Quebec

location_facility: Virginia Commonwealth University Health System

location_facility: Strong Memorial Hospital of the University of Rochester

location_facility: University of Southern California Hospital

location_facility: Sacred Heart Medical Center at Riverbend

location_facility: University of Iowa Hospitals and Clinics

location_facility: Northern Indiana Research Alliance - Lutheran Hospital

location_facility: Cardiovascular Associates of the Delaware Valley

location_facility: Cooper Hospital - University Medical Center

location_facility: Huntsville Hospital - The Heart Center, PC

intervention_type: Device

lead_sponsor_type: industriel

status_simplified: Completed


intervention_type: Drug

lead_sponsor: Agios Pharmaceuticals, Inc.

summary: This clinical trial is a Phase 2/3 study that will determine the recommended dose of mitapivat and evaluate the efficacy and safety of mitapivat in sickle cell disease by testing how well mitapivat works compared to placebo to increase the amount of hemoglobin in the blood and to reduce or prevent the occurrence of sickle cell pain crises. In addition, the long-term effect of mitapivat on efficacy and safety will be explored in an open-label extension portion.

location_facility: Instituto do Cancer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo

location_facility: Mississippi Center for Advanced Medicine

location_facility: East Carolina University - Brody School of Medicine

location_facility: Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

location_facility: HEMORIO Instituto Nacional de Hematologia

location_facility: American University of Beirut Medical Center

location_facility: Hospital Das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP

location_facility: Seattle Cancer Care Alliance, University of Washington

location_facility: Penn Medicine - University of Pennsylvania Health System

location_facility: Manchester Royal Infirmary, Manchester University NHS Foundation Trust

location_facility: Cambridge University Hospitals NHS Foundation Trust

location_facility: University of Texas Health Science Center of Houston

location_facility: King Abdullah International Medical Research Center

location_facility: Kenya Medical Research Institute (KEMRI) Centre for Clinical Research Butere County Hospital

location_facility: Hammoud Hospital University Medical Center

location_facility: AOU dell'Università degli Studi della Campania Luigi Vanvitelli

location_facility: Cure 4 The Kids Foundation, A Division of Roseman University of Health Sciences

location_facility: Institut Universitaire du Cancer de Toulouse - Oncopole

location_facility: Penn State Health Milton S. Hershey Medical Center

location_facility: Sultan Qaboos University Hospital, Hematology Department, COM&HS

location_facility: Kaiser Permanente - Largo Medical Center

location_facility: Boston Medical Center & Boston University School of Medicine

location_facility: Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)

status: Recruiting

title: A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Mitapivat in Subjects With Sickle Cell Disease

primary_purpose: Treatment

type: EudraCT Number

source: euctr

enrollment_type: Anticipated

design_allocation: Randomized

study_completion_date_type: Anticipated

location_country:
Germany
Italy
Israel
Nigeria
United Kingdom
Brazil
Netherlands
Lebanon
Belgium
United States
Kenya
Saudi Arabia
Turkey
Oman
Canada
France

status_simplified: Ongoing


title: SafeHeal Colovac Colorectal Anastomosis Protection Device Evaluation (SAFE-2) Pivotal Study: A Study to Evaluate the Safety and Effectiveness of the Colovac Colorectal Anastomosis Protection Device

summary: A randomized trial to assess the safety and effectiveness of the Colovac in providing temporary protection of the anastomosis in subjects undergoing lower anterior resection for colorectal cancer.

status: Suspended

lead_sponsor: SafeHeal Inc

location_country:
United States
Belgium
France

location_facility:
Tampa General Hospital
ICM Val d'Aurelle
USC Keck Hospital
Lenox Hill Hospital
Hopital Saint-Louis
Universitair Ziekenhuis Antwerpen
Kaiser Permanente - Los Angeles
Dartmouth-Hitchcock
Hôpital Saint Antoine Paris
CHU Rouen Normandie
CHU de Besancon
UMass Memorial Medical Center
Cedars-Sinai Medical Center
Lankenau Medical Center
Mount Sinai Hospital
Maimonides Medical Center

status_simplified: Unknown


title: A Phase 1 First In Human Study Evaluating Safety And Efficacy Of ABBV-637 As Either Monotherapy Or In Combination In Adult Subjects With Relapsed And Refractory Solid Tumors

summary:
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-Small Cell Lung Cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to evaluate the safety and efficacy (how well the study drug works against the disease) of ABBV-637 alone or in combination with docetaxel/osimertinib in participants with solid tumors (NSCLC). Adverse events and change in disease activity will be assessed.

ABBV-637 is an investigational drug being developed for the treatment of solid tumors. Study consists of 3 parts - monotherapy dose escalation (Part 1), combination dose escalation and expansion (Parts 2a and 2b) with docetaxel and combination dose escalation and expansion (Parts 3a and 3b) with osimertinib. Approximately 109 adult participants with relapsed/refractory (R/R) solid tumors will be enrolled in approximately 30 sites across the world.

In Part 1, participants with solid tumors will receive intravenous (IV) ABBV-637 in 28-day cycles. In Part 2a and 2b, participants will receive IV ABBV-637 in combination with IV docetaxel in 28-day cycles. In Part 3a and 3b, participants will receive intravenous (IV) ABBV-637 in combination with daily oral tablets of osimertinib in 28-day cycle.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. Treatment effects will be monitored by medical assessments, blood tests, side effect reporting, and questionnaires.

status: Active, not recruiting

design_allocation: Non-Randomized

lead_sponsor: AbbVie

location_country:
France
Australia
Japan
United States
Korea, Republic of
Spain
Taiwan
Israel

location_facility: Hospital Universitario 12 de Octubre /ID# 225977

location_facility: Lifespan Cancer Institute at Rhode Island Hospital /ID# 226145

location_facility: Virginia Cancer Specialists - Fairfax /ID# 225693

location_facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 225975

location_facility: Dana-Farber Cancer Institute /ID# 231209

location_facility: Linkou Chang Gung Memorial Hospital /ID# 225946

location_facility: Carolina BioOncology Institute /ID# 225358

location_facility: National Hospital Organization Kyushu Cancer Center /ID# 240761

location_facility: The Chaim Sheba Medical Center /ID# 225585

location_facility: National Cancer Center Hospital East /ID# 225725

location_facility: National Cheng Kung University Hospital /ID# 225944

location_facility: South Texas Accelerated Research Therapeutics /ID# 225359

location_facility: National Taiwan University Hospital - Hsinchu branch /ID# 243610

location_facility: Washington University-School of Medicine /ID# 225698

location_facility: Centre Georges François Leclerc /ID# 226760

location_facility: Hospital Universitario Vall d'Hebron /ID# 225976

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 243345

location_facility: Hospital Universitario Virgen de la Victoria /ID# 225978

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 226096

location_facility: Yonsei University Health System Severance Hospital /ID# 233774

location_facility: National Cancer Center Hospital /ID# 225724

location_facility: AP-HM - Hopital de la Timone /ID# 225779

location_facility: National Hospital Organization Shikoku Cancer Center /ID# 240821


type: Other Identifier

title: A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B

summary:
Substudy 02B is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study.

The goal of substudy 02B is to evaluate the safety and efficacy of investigational treatment arms in participants with 1L advanced melanoma and to identify the investigational agent(s) that, when used in combination, are superior to the current treatment options/pembrolizumab monotherapy.

Arm 1: Pembrolizumab + Vibostolimab was added in the base protocol on 13-Nov-2019, and enrollment into this arm has been completed. Arm 2: Pembrolizumab was added in the base protocol on 13-Nov-2019, and enrollment stopped prematurely on 15-Aug-2022. Arm 3: Coformulation Pembrolizumab/Quavonlimab was added in Amendment 01 on 20-Oct-2020, and enrollment stopped prematurely on 15-Aug-2022. Arm 4: Coformulation Pembrolizumab/Quavonlimab + Lenvatinib was added in Amendment 01 on 20-Oct-2020, and enrollment is ongoing. Arm 5: Coformulation Favezelimab/Pembrolizumab, Arm 6: Coformulation Favezelimab/Pembrolizumab + All-trans Retinoic Acid (ATRA), and Arm 7: Coformulation Favezelimab/Pembrolizumab + Vibostolimab were added in Amendment 04 on 10-May-2023, and enrollment for these arms will be initiated in July 2023.

ipd_sharing: Yes

lead_sponsor: Merck Sharp & Dohme LLC

location_country:
Italy
Poland
Israel
Australia
Switzerland
United States
Spain
Greece
South Africa
Chile
France

location_facility: West Cancer Center - East Campus ( Site 2014)

location_facility: General Hospital of Athens "Laiko"-First Department of Internal Medicine ( Site 2212)

location_facility: Istituto Oncologico Veneto IRCCS ( Site 2355)

location_facility: Policlinico Le Scotte - A.O. Senese ( Site 2377)

location_facility: Inova Schar Cancer Institute ( Site 2011)

location_facility: A.P.H. Paris, Hopital Saint Louis ( Site 2107)

location_facility: Istituto Europeo di Oncologia ( Site 2301)

location_facility: Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2863)

location_facility: Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 2231)

location_facility: LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2861)

location_facility: Rabin Medical Center-Oncology ( Site 2705)

location_facility: HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Sit

location_facility: Tasman Oncology Research Pty Ltd ( Site 2403)

location_facility: Providence Saint John's Health Center ( Site 2010)

location_facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (

location_facility: Hôpitaux Universitaires de Genève (HUG)-Oncology ( Site 2603)

location_facility: Hospital Universitario Ramón y Cajal ( Site 2802)

location_facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 2022)

location_facility: Hadassah Ein Karem Jerusalem ( Site 2702)

location_facility: Calvary Mater Newcastle-Medical Oncology ( Site 2404)

location_facility: CHU de Bordeaux- Hopital Saint Andre ( Site 2108)

location_facility: Istituto Nazionale Tumori Fondazione Pascale ( Site 2302)

location_facility: CHUV Centre Hospitalier Universitaire Vaudois ( Site 2602)

location_facility: Rambam Health Care Campus-Oncology ( Site 2704)

location_facility: The Angeles Clinic and Research Institute ( Site 2009)

location_facility: Steve Biko Academic Hospital-Medical Oncology ( Site 2862)

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2399)

location_facility: Melanoma Institute Australia ( Site 2402)

location_facility: Universitaetsspital Zuerich ( Site 2601)

location_facility: CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE ( Site 2865)

location_facility: Oregon Health & Science University ( Site 2013)

location_facility: University of Colorado, Anschutz Cancer Pavilion ( Site 2012)

location_facility: University of Pennsylvania Abramson Cancer Center ( Site 2008)


title: A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02C

summary:
Substudy 02C is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study.

The goal of substudy 02C is to evaluate the safety and efficacy of investigational treatment arms in participants with Stage III melanoma who are candidates for neoadjuvant therapy to identify the investigational agent(s) that, when used in combination, are superior to the current treatment options/historical control available.

Arm 1: Pembrolizumab + Vibostolimab, Arm 2: Pembrolizumab + Gebasaxturev, and Arm 3: Pembrolizumab were added in the base protocol on 13-Nov-2019, and enrollment into those arms has been completed. Arm 4: Pembrolizumab + MK-4830 was added in Amendment 04 on 20-Dec-2021, and enrollment into that arm has been completed. Arm 5: Favezelimab + Pembrolizumab and Arm 6: Pembrolizumab + all-trans retinoic acid (ATRA) were added in Amendment 06 on 25-Jun-2022, and enrollment is ongoing.

location_country:
France
Italy
Australia
Switzerland
United States
Israel

location_facility: The Angeles Clinic and Research Institute ( Site 3009)

location_facility: University of Pennsylvania Abramson Cancer Center ( Site 3008)

location_facility: West Cancer Center - East Campus ( Site 3014)

location_facility: Policlinico Le Scotte - A.O. Senese ( Site 3377)

location_facility: A.P.H. Paris, Hopital Saint Louis ( Site 3107)

location_facility: Providence Saint John's Health Center ( Site 3010)

location_facility: Universitaetsspital Zuerich ( Site 3601)

location_facility: Hôpitaux Universitaires de Genève (HUG)-Oncology ( Site 3603)

location_facility: CHUV Centre Hospitalier Universitaire Vaudois ( Site 3602)

location_facility: Centre Hospitalier Lyon Sud ( Site 3102)

location_facility: Rambam Health Care Campus-Oncology ( Site 3704)

location_facility: University of Colorado, Anschutz Cancer Pavilion ( Site 3012)

location_facility: Rabin Medical Center-Oncology ( Site 3705)

location_facility: Hadassah Ein Karem Jerusalem ( Site 3702)

location_facility: Istituto Europeo di Oncologia ( Site 3301)

location_facility: Inova Schar Cancer Institute ( Site 3011)

location_facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 3022)

location_facility: Oregon Health & Science University ( Site 3013)

location_facility: Tasman Oncology Research Pty Ltd ( Site 3403)

location_facility: Melanoma Institute Australia ( Site 3402)


intervention_type: Other

acronym: Efficacy, immunogenicity, and safety of the 9vHPV vaccine in adult males 20 to 45 years of age

summary:
The purpose of this study is to evaluate the efficacy, immunogenicity and safety of the 9-valent human papillomavirus (9vHPV) vaccine in men 20 to 45 years of age. The primary hypothesis tested after the primary database lock is that administration of a 3-dose regimen of 9vHPV vaccine will reduce the incidence of HPV 16/18/31/33/45/52/58-related oral persistent infection (6 months or longer) compared with placebo.

There will also be an Extension Study to offer an opportunity to complete the 3 dose regimen of 9vHPV vaccine for participants who received placebo in the Base Study, or received less than 3 doses of 9vHPV vaccine in the Base Study.

ReferenceType: derived

ReferenceCitation: Giuliano AR. Initiation of three complementary international studies investigating prevalence of oral HPV infection, burden of HPV-related head and neck disease, and efficacy of 9-valent HPV vaccination against oral HPV persistent infection. Contemp Clin Trials. 2022 Apr;115:106629. doi: 10.1016/j.cct.2021.106629. Epub 2021 Nov 24. No abstract available.

oa_host_type: closed

repositories_concat: closed

ReferenceCitation: Morais E, Kothari S, Roberts C, Yen G, Chen YT, Lynam M, Pedros M, Mirghani H, Alemany L, Pavon MA, Waterboer T, Mehanna H, Giuliano AR. Oral human papillomavirus (HPV) and associated factors among healthy populations: The design of the PROGRESS (PRevalence of Oral hpv infection, a Global aSSessment) study. Contemp Clin Trials. 2022 Apr;115:106630. doi: 10.1016/j.cct.2021.106630. Epub 2021 Nov 25.

ReferenceCitation: Giuliano AR, Wilkin T, Bautista OM, Cheon K, Connor L, Dubey S; Thomas Group; Luxembourg A, Rawat S, Shaw A, Velicer C, Vendetti N, Tu Y. Design of a phase III efficacy, immunogenicity, and safety study of 9-valent human papillomavirus vaccine in prevention of oral persistent infection in men. Contemp Clin Trials. 2022 Apr;115:106592. doi: 10.1016/j.cct.2021.106592. Epub 2021 Oct 19.

location_facility: CHU Dijon Bourgogne - Hopital F. Mitterrand ( Site 0223)

location_facility: Rapid Medical Research, Inc. ( Site 0037)

location_facility: P-One Clinic, Keikokai Medical Corp. ( Site 1101)

location_facility: Azienda Ospedaliera Policlinico di Bari ( Site 0550)

location_facility: Hallym University Kangnam Sacred Heart Hospital ( Site 0951)

location_facility: Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0755)

location_facility: Instituto Nacional de Salud Publica ( Site 0202)

location_facility: Crossroads Clinical Research LLC ( Site 0027)

location_facility: Infektiologikum Frankfurt-Sachsenhausen ( Site 0456)

location_facility: Medical Corporation Shinanokai Shinanozaka Clinic ( Site 1106)

location_facility: Medical Corporation Mori to Umi Tokyo Tokyo Kamata Hospital ( Site 1112)

location_facility: Vaccine Trial Center Faculty of Tropical Medicine ( Site 1052)

location_facility: Clinical Research Partners, LLC. ( Site 0004)

location_facility: Solaris Clinical Research, LLC ( Site 0003)

location_facility: Cotton-O'Neil Clinical Research Center ( Site 0044)

location_facility: Centro de Pesquisa Clinica II - ICHC - FMUSP ( Site 0102)

location_facility: Doujin Memorial Medical Foundation, Meiwa Hospital ( Site 1111)

location_facility: Souseikai Nishikumamoto Hospital ( Site 1104)

location_facility: J Lewis Research Inc/Foothill Family Clinic South ( Site 0006)

location_facility: Maccabi Health Services Medical Center ( Site 0604)

location_facility: Kentucky Pediatric/Adult Research Inc ( Site 0011)

location_facility: National Cheng Kung University Hospital ( Site 1002)

location_facility: National Taiwan University Hospital ( Site 1000)

location_facility: Investigaciones Medicas en Salud - INMENSA ( Site 0255)

location_facility: Chang Gung Medical Foundation.Linkou Branch ( Site 1001)

location_facility: Policlinico Universidad Nacional Mayor de San Marcos ( Site 0257)

location_facility: Centrum ambulantni gynekologie a primarni pece ( Site 0401)

location_facility: Alliance for Multispecialty Reseach, LLC ( Site 0021)

location_facility: Rochester Clinical Research, Inc. ( Site 0008)

location_facility: Universitatsklinikum Hamburg-Eppendorf ( Site 0451)

location_facility: Certified Research Associates ( Site 0041)

location_facility: ARKE Estudios Clinicos S.A de C.V ( Site 0211)

location_facility: Arke Estudios Clinicos S.A. de C.V. ( Site 0203)

location_facility: Faculty of Medicine Siriraj Hospital ( Site 1050)

location_facility: Heartland Research Associates, LLC ( Site 0034)

location_facility: Korea University Ansan Hospital ( Site 0952)

location_facility: Clinical Research of South Florida ( Site 0036)

location_facility: Charlottesville Medical Research Center, LLC ( Site 0007)

location_facility: Icaro Investigaciones en Medicina S.A. de C.V. ( Site 0200)

location_facility: Coastal Carolina Research Center ( Site 0043)

location_facility: Centro de Atención e Investigación Médica SAS - CAIMED CHIA ( Site 0156)

location_facility: Hadassah Medical Center. Ein Kerem ( Site 0600)

location_facility: Instituto de Investigacion Nutricional - Anexo Huascar ( Site 0251)

location_facility: Armed Forces Research Institute of Medical Sciences ( Site 1051)

location_facility: Asociacion Civil Selva Amazonica ( Site 0252)

location_facility: Medical Corporation Iseikai My City Clinic ( Site 1108)

location_facility: CHU Nantes - Hopital Hotel Dieu ( Site 0510)

location_facility: Hospital Santo Antonio - Obras Sociais Irma Dulce ( Site 0101)

location_facility: Health Research of Hampton Roads, Inc. ( Site 0015)

location_facility: Medical Corporation Heishinkai OPHAC Hospital ( Site 1105)

location_facility: AOU Policlinico Vittorio Emanuele ( Site 0552)

location_facility: Medical Corporation Houeikai Sekino Clinical Pharmacology Clinic ( Site 1102)

location_facility: The Catholic University of Korea Eunpyeong St Mary s Hospital ( Site 0954)

location_facility: Research Institute for Health Sciences ( Site 1053)

location_facility: Encompass Clinical Research ( Site 0028)

location_facility: C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 0507)

location_facility: University of Texas Medical Branch at Galveston ( Site 0038)

location_facility: Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 0551)

location_facility: Medical Corporation Seiwakai Hayakawa Clinic ( Site 1113)

location_facility: Preferred Primary Care Physicians ( Site 0032)

location_facility: Korea University Guro Hospital ( Site 0950)

location_facility: Universitair Ziekenhuis Gasthuisberg ( Site 0353)

location_facility: Azienda Ospedaliera - Universita di Padova ( Site 0555)

location_facility: Universita di Roma "La Sapienza" ( Site 0553)

location_facility: Alta California Medical Group ( Site 0031)

location_facility: Healthcare Research Network LLC ( Site 0035)

location_facility: Chang Gung Medical Foundation. Kaohsiung Branch ( Site 1003)

location_facility: Texas Center For Drug Development ( Site 0013)

location_facility: Valley Clinical Trials Inc. ( Site 0002)

location_facility: J Lewis Research Inc/Jordan River Family Medicine ( Site 0023)

location_facility: Diablo Clinical Research, Inc ( Site 0042)

location_facility: Fundacion Centro de Investigacion Clinica CIC ( Site 0153)

location_facility: Inland Empire Clinical Trials, LLC ( Site 0025)

location_facility: Acevedo Clinical Research Associates ( Site 0001)

title: A Phase 3, International, Multi-center, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy, Immunogenicity, and Safety of the 9vHPV Vaccine, a Multivalent L1 Virus-like Particle Vaccine, in the Prevention of Oral Persistent Infection With HPV Types 16, 18, 31, 33, 45, 52, or 58 in Adult Males, 20 to 45 Years of Age

primary_purpose: Prevention

type: Registry Identifier

location_country:
Germany
Italy
Colombia
Israel
Japan
Brazil
Mexico
Belgium
United States
Korea, Republic of
Spain
Thailand
Taiwan
Czechia
Peru
France


title: A Phase 1, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Combinations of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Subjects With Locally Advanced or Metastatic Solid Tumors

summary: A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum tolerated dose (RP2D/MTD) is determined in the dose-escalation phase.

location_country:
France
Australia
United States
Spain
Taiwan
Israel

location_facility: Highlands Oncology Group, PA /ID# 218863

location_facility: Hospital Universitario Virgen de la Victoria /ID# 221671

location_facility: Hospital Universitario HM Sanchinarro /ID# 212805

location_facility: Hospital Universitario Vall d'Hebron /ID# 212804

location_facility: China Medical University Hospital /ID# 221090

location_facility: Institut de Cancérologie de l'Ouest René Gauducheau /ID# 212880

location_facility: Carolina BioOncology Institute /ID# 210664

location_facility: Mary Crowley Cancer Research /ID# 210716

location_facility: AP-HP - Hopital Bichat - Claude-Bernard /ID# 212869

location_facility: Washington University-School of Medicine /ID# 221399

location_facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 212806

location_facility: The Chaim Sheba Medical Center /ID# 211699

location_facility: Virginia Cancer Specialists - Fairfax /ID# 210671

location_facility: Tennessee Oncology-Nashville Centennial /ID# 221400

location_facility: Fort Wayne Medical Oncology and Hematology, Inc /ID# 226072

location_facility: National Taiwan University Hospital /ID# 210993

location_facility: St Jude Hospital dba St Joseph /ID# 211130


summary: The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

ReferenceCitation: Mendes-Bastos P, Ladizinski B, Guttman-Yassky E, Jiang P, Liu J, Prajapati VH, Simpson EL, Vigna N, Teixeira HD, Barbarot S. Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials. J Am Acad Dermatol. 2022 Oct;87(4):784-791. doi: 10.1016/j.jaad.2022.06.012. Epub 2022 Jun 15.

oa_host_type: repository

repository_institution: CCSD (Centre pour la Communication Scientifique Directe) - HAL - Nantes Université

repositories_concat: HAL

unpaywall_oa_status: green

ReferenceCitation: Simpson EL, Papp KA, Blauvelt A, Chu CY, Hong HC, Katoh N, Calimlim BM, Thyssen JP, Chiou AS, Bissonnette R, Stein Gold LF, Wegzyn C, Hu X, Liu M, Liu J, Tenorio AR, Chu AD, Guttman-Yassky E. Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials. JAMA Dermatol. 2022 Apr 1;158(4):404-413. doi: 10.1001/jamadermatol.2022.0029.

evidence: open (via free pdf)

repositories_concat: PubMed Central

publisher_dissemination: American Medical Association

ReferenceCitation: Guttman-Yassky E, Teixeira HD, Simpson EL, Papp KA, Pangan AL, Blauvelt A, Thaci D, Chu CY, Hong HC, Katoh N, Paller AS, Calimlim B, Gu Y, Hu X, Liu M, Yang Y, Liu J, Tenorio AR, Chu AD, Irvine AD. Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials. Lancet. 2021 Jun 5;397(10290):2151-2168. doi: 10.1016/S0140-6736(21)00588-2. Epub 2021 May 21. Erratum In: Lancet. 2021 Jun 5;397(10290):2150.

location_facility: Southern California Derma. Inc /ID# 205734

location_facility: The Dermatology Clinic of Arkansas /ID# 218749

location_facility: PMG Research of Wilmington LLC /ID# 205968

location_facility: University of New Mexico School of Medicine /ID# 206756

location_facility: National University Hospital /ID# 205224

location_facility: Centre Hospitalier Universitaire du Sart Tilman CHU de Liege /ID# 204938

location_facility: UBC Department of Dermatology and Skin Science The Skin Care Centre /ID# 207837

location_facility: University Hospital Plymouth NHS Trust /ID# 204649

location_facility: Dermatologische Gemeinschaftspraxis Mahlow /ID# 205765

location_facility: The Catholic University of Korea Incheon St.Mary's Hospital /ID# 206529

location_facility: Medical center Sveti Panteleimon /ID# 210414

location_facility: Acibadem City Clinic Tokuda University Hospital EAD /ID# 205292

location_facility: Advanced Research for Health Improvement /ID# 218003

location_facility: CHRU de Brest - Hopital Morvan /ID# 206555

location_facility: Hospital Parc de Salut del Mar /ID# 204709

location_facility: Agile Clinical Research Trials /ID# 218080

location_facility: Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o. z. /ID# 205097

location_facility: University Hospital Southampton NHS Foundation Trust /ID# 205711

location_facility: Awasty Research Network, LLC /ID# 206748

location_facility: Arizona Research Center, Inc. /ID# 205795

location_facility: Child Hosp of Orange County,CA /ID# 205735

location_facility: Timber Lane Allergy & Asthma Research, LLC /ID# 206897

location_facility: Georgia Pollens Clinical Research Centers, Inc /ID# 218567

location_facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 205839

location_facility: Chung-Ang University Hostipal /ID# 206397

location_facility: Clinical Research Trials of Florida, Inc. /ID# 206840

location_facility: Haut- und Laserzentrum Hunsrück /ID# 205768

location_facility: 401 GSNA - 401 Army General Hospital /ID# 205352

location_facility: Taipei Medical University Shuang Ho Hospital /ID# 204804

location_facility: General Hospital Andreas Syggros /ID# 204527

location_facility: Clinical Investigation Specialists, Inc. /ID# 206898

location_facility: Universitaetsklinikum Hamburg-Eppendorf (UKE) /ID# 207982

location_facility: Advanced Research for Health Improvement /ID# 217987

location_facility: Keck School of Medicine of USC /ID# 206971

location_facility: Austin Institute for Clinical Research /ID# 206640

location_facility: Sjællands Universitetshospital /ID# 205960

location_facility: Centro Hospitalar de Leiria, EPE /ID# 209906

location_facility: KK Women's & Children Hospital /ID# 206693

location_facility: Treasure Valley Medical Research /ID# 210298

location_facility: ASST Spedali civili di Brescia /ID# 205927

location_facility: The Royal Melbourne Hospital /ID# 205919

location_facility: Universitaetsklinikum St. Poelten /ID# 206909

location_facility: DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 205429

location_facility: New England Research Associates, LLC /ID# 206896

location_facility: IRCCS Istituti Fisioterapici Ospitalieri-Istituto Dermatologico San Gallicano /ID# 205986

location_facility: Hospital Vital Alvarez Buylla /ID# 205770

location_facility: University of California Irvine /ID# 205136

location_facility: Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 205085

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 205679

location_facility: Clinical Research of West Florida, Inc /ID# 206146

location_facility: Epiphany Dermatology - Fort Worth /ID# 210073

location_facility: Sanatorium profesora Arenbergera /ID# 205098

location_facility: Innovative Clinical Research - Lafayette /ID# 208400

location_facility: Military Medical Academy Multiprofile Hospital /ID# 205291

location_facility: Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 205611

location_facility: Ideal Clinical Research Inc. /ID# 209880

location_facility: Midflorida Clinical Research, Inc. /ID# 213700

location_facility: Hospital Clinic de Barcelona /ID# 210564

location_facility: Rady Children's Hospital San Diego /ID# 208244

location_facility: Murdoch Children's Research Institute /ID# 205667

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 206895

location_facility: Skin Laser and Surgery Specialists of NY and NJ /ID# 206754

location_facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 208281

location_facility: National Taiwan University Hospital /ID# 204803

location_facility: SimcoDerm Medical and Surgical Dermatology Center /ID# 206333

location_facility: Marietta Dermatology Clinical Research /ID# 210317

location_facility: Niakosari Medicine Professional Corporation /ID# 206004

location_facility: CCA Braga - Hospital de Braga /ID# 205854

location_facility: Papageorgiou General Hospital Thessaloniki /ID# 204526

location_facility: Total Skin and Beauty Derm Ctr /ID# 205129

location_facility: Azienda Ospedaliero-Universitaria di Modena /ID# 205169

location_facility: Hospital Infantil Universitario Nino Jesus /ID# 210437

location_facility: Allergy Research Canada Inc. /ID# 213547

location_facility: Seoul National University Hospital /ID# 206396

location_facility: Medical Dermatology Specialist /ID# 205516

location_facility: Ordensklinikum Linz GmbH Elisabethinen /ID# 206573

location_facility: The Guenther Dermatology Research Centre /ID# 206772

location_facility: Velocity Clinical Research Hallandale Beach /ID# 207544

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 206658

location_facility: 251 Airforce General Hospital /ID# 205841

location_facility: Palmtree Clinical Research Inc. /Id# 206184

location_facility: Clinical Investigation Specialist, Inc - Kenosha /ID# 215933

location_facility: Dr. Lyne Giroux Medicine Professional Corporation /ID# 206771

location_facility: Vital Prospects Clinical Research Institute, PC /ID# 205824

location_facility: Hospital General Universitario Gregorio Maranon /ID# 204380

location_facility: Dr. S.K. Siddha Medicine Professional Corporation /ID# 207138

location_facility: Azienda Ospedaliero Universitaria di Cagliari- Presidio Ospedaliero /ID# 205168

location_facility: Clinical Research Solutions, LLC /ID# 218416

location_facility: Derm Clin Res Ctr San Antonio /ID# 205469

location_facility: Presidio Ospedaliero San Salvatore /ID# 205167

location_facility: Hospital Universitario Infanta Leonor /ID# 204710

location_facility: Dermatology Treatment and Research Center, PA /ID# 205473

location_facility: University Hospitals Case Medical Center /ID# 206639

location_facility: Allergy, Asthma & Immunology Associates, PC /ID# 218169

location_facility: South Infirmary Victoria University Hospital /ID# 204265

location_facility: University Hospital Waterford /ID# 204266

location_facility: Duplicate_Summit Medical Group /ID# 213863

location_facility: Poliklinika Vlatka Cavka d.o.o. /ID# 211126

location_facility: SoonChunHyang University Buchon Hospital /ID# 206391

location_facility: Chung Shan Medical University Hospital /ID# 205092

location_facility: Universal Axon Clinical Research /ID# 213703

location_facility: Northshore University Health System Dermatology Clinical Trials Unit /ID# 205135

location_facility: Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 205766

location_facility: Linkou Chang Gung Memorial Ho /ID# 204783

location_facility: Hospital Universitario Reina Sofia /ID# 204712

location_facility: Hallym University Kangnam Sacred Heart Hospital /ID# 206343

location_facility: The Education & Research Foundation, Inc. /ID# 206900

location_facility: Dr. Dusan Sajic Medicine Professional Corporation /ID# 206890

location_facility: CHP, EPE- Hospital Geral de Sa /ID# 205187

location_facility: Continental Clinical Solutions /ID# 210327

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 204993

location_facility: Naftalan - Specijalna bolnica za medicinsku rehabilitaciju /ID# 203448

location_facility: Hospital General Universitario de Valencia /ID# 210565

location_facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 205987

location_facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 205767

location_facility: Vseobecna fakultni nemocnice v Praze /ID# 205201

location_facility: Bellingham Asthma Allergy and Immunology Clinic /ID# 210357

location_facility: Universitair Medisch Centrum Groningen /ID# 205162

location_facility: Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz /ID# 218072

location_facility: Beacon Clinical Research, LLC /ID# 206894

location_facility: Miami Dade Medical Research Institute /ID# 209413

location_facility: Korea University Ansan Hospital /ID# 206342

title: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

location_country:
Germany
Ireland
New Zealand
Australia
Croatia
Czechia
Canada
France
Portugal
Hungary
Denmark
United States
Belgium
Italy
United Kingdom
Singapore
Netherlands
Austria
Korea, Republic of
Spain
Greece
Taiwan
Bulgaria


title: Brigatinib in Patients With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib

summary: The primary purpose of this study is to determine the efficacy of brigatinib by confirmed objective response rate (ORR) by response evaluation criteria in solid tumors (Response Evaluation Criteria in Solid Tumors [RECIST]), in participants with ALK+ locally advanced or metastatic NSCLC whose disease has progressed on therapy with alectinib or ceritinib.

ReferenceCitation: Kim ES, Barlesi F, Mok T, Ahn MJ, Shen J, Zhang P, Ou SI. ALTA-2: Phase II study of brigatinib in patients with ALK-positive, advanced non-small-cell lung cancer who progressed on alectinib or ceritinib. Future Oncol. 2021 May;17(14):1709-1719. doi: 10.2217/fon-2020-1119. Epub 2021 Feb 11.

oa_host_type: publisher

publisher_dissemination: Future Science Ltd

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

lead_sponsor: Ariad Pharmaceuticals

sponsor_collaborators:
Ariad Pharmaceuticals
Takeda

location_country:
Germany
Italy
Hong Kong
Australia
Japan
Netherlands
Austria
Sweden
United States
China
Korea, Republic of
Spain
Taiwan
Canada
France

location_facility: Centre de Lutte Contre le Cancer Centre Leon Berard

location_facility: The First Affiliated Hospital of Guangzhou Medical University

location_facility: Kansai Medical University Hirakata Hospital

location_facility: Institut Catala d'Oncologia Badalona - Hospital Germans Trias i Pujol

location_facility: The First Affiliated Hospital of Zhejiang University School of Medicine

location_facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale

location_facility: Azienda Ospedaliera San Camillo Forlanini

location_facility: Keimyung University Dongsan Medical Center

location_facility: The Cancer Institute Hospital of Japanese Foundation for Cancer Research

location_facility: USOR - Virginia Cancer Specialists - Fairfax Office

location_facility: Complejo Hospitalario Universitario A Coruna

location_facility: Assistance Publique-Hopitaux de Marseille Hopital Nord

location_facility: Jilin Provincial Cancer Hospital (Changchun Cancer Hospital)

location_facility: Azienda Ospedaliero - Universitaria San Luigi Gonzaga

location_facility: University of California Irvine Health Chao Family Comprehensive Cancer Center

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: Washington University School of Medicine

location_facility: Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: The Oncology Institute of Hope and Innovation

location_facility: Hopital Larrey, CHU de Toulouse, Service de Pneumologie

location_facility: Centre Hospitalier Intercommunal de Creteil

location_facility: USOR - Rocky Mountain Cancer Centers - Pueblo

location_facility: Peninsula & South Eastern Haematology and Oncology Group

location_facility: Centro di Riferimento Oncologico di Aviano


title: A Phase 2, Multicenter, Open-Label, 2-Cohort Study of Trastuzumab Deruxtecan (DS-8201a), an Anti-HER2 Antibody Drug Conjugate (ADC), for HER2-Over-Expressing or -Mutated, Unresectable and/or Metastatic Non Small Cell Lung Cancer (NSCLC) (DESTINY-Lung01)

summary: The primary objective of this trial is to evaluate the efficacy of trastuzumab deruxtecan in HER2-overexpressing and/or HER2-mutated advanced NSCLC participants.

ReferenceCitation: Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazieres J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Perol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Janne PA; DESTINY-Lung01 Trial Investigators. Trastuzumab Deruxtecan in HER2-Mutant Non-Small-Cell Lung Cancer. N Engl J Med. 2022 Jan 20;386(3):241-251. doi: 10.1056/NEJMoa2112431. Epub 2021 Sep 18.

oa_colors: green other

evidence: open (via free article)

version: acceptedVersion

repository_institution: University of California - eScholarship University of California

version: submittedVersion

repositories_concat: PubMed Central;escholarship.org

unpaywall_oa_status: bronze

publisher_dissemination: Massachusetts Medical Society

ipd_sharing_description: De-identified individual participant data (IPD) and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/

lead_sponsor: Daiichi Sankyo, Inc.

collaborators:
Daiichi Sankyo Co., Ltd.
AstraZeneca

sponsor_collaborators:
Daiichi Sankyo, Inc.
Daiichi Sankyo Co., Ltd.
AstraZeneca

location_country:
Japan
Netherlands
United States
Spain
France

location_facility: University of California San Diego (UCSD)

location_facility: Washington University School of Medicine at St. Louis


title: A Phase 1/2 Study of CPI-0610, a Small Molecule Inhibitor of BET Proteins: Phase 1 (Dose Escalation of CPI-0610 in Patients With Hematological Malignancies) and Phase 2 (Dose Expansion of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis and Essential Thrombocytopenia)

summary:
Phase 1 Part (Complete): Open-label, sequential dose escalation study of pelabresib in patients with previously treated Acute Leukemia, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasms, and Myelofibrosis.

Phase 2 Part: Open-label study of CPI-0610 with and without Ruxolitinib in patients with Myelofibrosis.

CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins.

ReferenceCitation: Zavidij O, Haradhvala NJ, Meyer R, Cui J, Verstovsek S, Oh S, Mead A, Taverna P. MPN-238 Single-Cell RNA Profiling of Myelofibrosis Patients Reveals Pelabresib-Induced Decrease of Megakaryocytic Progenitors and Normalization of CD4+ T Cells in Peripheral Blood. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S331-S332. doi: 10.1016/S2152-2650(22)01448-3.

lead_sponsor: Constellation Pharmaceuticals

sponsor_collaborators:
Constellation Pharmaceuticals
The Leukemia and Lymphoma Society

location_country:
Germany
Italy
Poland
United Kingdom
Netherlands
Belgium
United States
Canada
France

location_facility: Institut de cancérologie du Gard - Hematologie clinique

location_facility: Massachusetts General Hospital Cancer Center

location_facility: Instytut Hematologii i Transfuzjologii w Warszawie

location_facility: Institue of Hematology "L. and A. Seràgnoli"

location_facility: IRCCS Policlinico San Matteo, Università degli studi di Pavi

location_facility: CHRU de Lille - Hopital Claude Huriez - Maladies du Sang

location_facility: University College London Hospital's NHS foundation Trust

location_facility: Erasmus Universitair Medisch Centrum Rotterdam

location_facility: Guys and St Thomas' Hospital - Haematology

location_facility: AZ Sint-Jan Burgge-Oostende AV- Campus Sint-Jan

location_facility: Weill Medical College and New York Presbyterian Hospital

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: CHU - Hopital Saint Louis - Centre D'Investigations Clinique

location_facility: Froedtert & Medical College of Wisconsin

location_facility: Servizio Sanitario Regionale Emilia-Romagna - Azienda Unita Sanitaria Locale (AUSL) di Rimini - Ospedale Infermi di Rimini

location_facility: Washington University School of Medicne Neuromuscular Division Department of Neurology Research

location_facility: Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda

location_facility: Ospedale di Circolo, PO Varese, AO Ospedale di Circolo e Fon

location_facility: AOU S.Martino, IRCCS, IST-Istituto Nazionale Ricerca Sul Can

location_facility: Northwestern University - Lurie Comprehensive Cancer Center


title: A 12-Week Double-blind, Randomised, Placebo-controlled, Parallel Group Phase III Study, Followed by a 4-Week Randomised Withdrawal Period to Evaluate the Efficacy and Safety of Oral Ibodutant 10 mg Once Daily in Female Patients With Irritable Bowel Syndrome With Diarrhea

summary: Irritable Bowel Syndrome with diarrhoea (IBS-D) is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort and diarrhoea. This trial aims at the evaluation of the efficacy and safety of oral ibodutant 10 mg once daily as compared to placebo in women with IBS-D over a 12-week treatment period.

lead_sponsor: Menarini Group

location_country:
Germany
Italy
Poland
United Kingdom
Romania
United States
Spain
Bulgaria
Czech Republic
Russian Federation
France


title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Ranolazine on Major Adverse Cardiovascular Events in Subjects With a History of Chronic Angina Who Undergo Percutaneous Coronary Intervention With Incomplete Revascularization

acronym: RIVER-PCI

summary: This study will evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in chronic angina subjects with incomplete revascularization post-percutaneous coronary intervention (PCI; formerly known as angioplasty with stent) on the composite of ischemia-driven revascularization or ischemia-driven hospitalization without revascularization.

ReferenceCitation: Weisz G, Farzaneh-Far R, Ben-Yehuda O, Debruyne B, Montalescot G, Lerman A, Mahmud E, Alexander KP, Ohman EM, White HD, Olmsted A, Walker GA, Stone GW. Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial. Am Heart J. 2013 Dec;166(6):953-959.e3. doi: 10.1016/j.ahj.2013.08.004. Epub 2013 Oct 16.

ReferenceCitation: Weisz G, Genereux P, Iniguez A, Zurakowski A, Shechter M, Alexander KP, Dressler O, Osmukhina A, James S, Ohman EM, Ben-Yehuda O, Farzaneh-Far R, Stone GW; RIVER-PCI investigators. Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2016 Jan 9;387(10014):136-45. doi: 10.1016/S0140-6736(15)00459-6. Epub 2015 Oct 22.

ReferenceCitation: Alexander KP, Weisz G, Prather K, James S, Mark DB, Anstrom KJ, Davidson-Ray L, Witkowski A, Mulkay AJ, Osmukhina A, Farzaneh-Far R, Ben-Yehuda O, Stone GW, Ohman EM. Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial. Circulation. 2016 Jan 5;133(1):39-47. doi: 10.1161/CIRCULATIONAHA.115.019768. Epub 2015 Nov 10.

ReferenceCitation: Fanaroff AC, Prather K, Brucker A, Wojdyla D, Davidson-Ray L, Mark DB, Williams RB, Barefoot J, Weisz G, Ben-Yehuda O, Stone GW, Ohman EM, Alexander KP. Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris. Am J Cardiol. 2019 May 1;123(9):1399-1405. doi: 10.1016/j.amjcard.2019.01.036. Epub 2019 Feb 7.

repository_institution: PubMed Central - Europe PMC

lead_sponsor: Gilead Sciences

location_country:
France
Germany
Italy
Poland
Israel
United Kingdom
Sweden
Netherlands
Austria
Belgium
United States
Spain
Canada
Russian Federation
Czech Republic

location_facility: City Clinical Hospital #15 named after O.M. Filatov

location_facility: National Research Center For Preventive Medicine

location_facility: SPZOZ, SPSK nr 7 Slaskiego Uniwersytetu Medycznego w Katowicach, Górnoslaskie Centrum Medyczne

location_facility: Samodzielny Publiczny Szpital Kliniczny nr. 1 im. Przemienienia Panskiego

location_facility: Hospital Universitario Marques de Valdecilla

location_facility: Cardiology Associates of North Mississippi

location_facility: Research Institute for Complex Issues of Cardiovascular Diseases

location_facility: San Antonio Endovascular and Heart Institute

location_facility: Buffalo Cardiology and Pulmonary Associates, PC

location_facility: SPZOZ, Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie

location_facility: Scientific and Research Institution Of Cardiology

location_facility: Pepin Heart Hospital and Dr. Kiran C. Patel Research Institute

location_facility: Northwest Indiana Cardiovascular Physicians

location_facility: City Clinical Hospital # 23 n.a."Medsantrud"

location_facility: Wojewódzki Szpital Zespolony im. Ludwika Rydygiera w Toruniu

location_facility: Ashford and Saint Peter's Hospital NHS Trust

location_facility: Spectrum Clinical Research Institute, Inc

location_facility: Sentara Cardiovascular Research Institute

location_facility: Azienda Ospedaliera "Maggiore della Carita" di Novara

location_facility: Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie

location_facility: Centre Hospitalier Universitaire Sart Tilman Liège

location_facility: Azienda Ospedaliera S. Sebastiano di Caserta

location_facility: Oklahoma City Veterans' Affairs Medical Center

location_facility: Azienda Ospedaliera Universitaria San Martino

location_facility: Centennial Heart Cardiovascular Consultants, LLC

location_facility: University of Vermont Medical Center, Fletcher Allen Health Care

location_facility: Cardiovascular Institute of Northwest Florida

location_facility: Centre Hospitalier de l'Universite de Montreal (CHUM)

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: Volgograd Regional Clinical Cardiological Center

location_facility: Hospital General Universitario de Alicante

location_facility: Cardiology Associates of Southeast Ohio, Inc.

location_facility: Veterans Affairs Medical Center, Duke University Medical Center

location_facility: Scarborough Cardiology Research Associates

location_facility: Fondazione Centro S. Raffaele del Monte Tabor, Ospedale San Raffaele

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Federal Center of Heart, Blood and Endocrinology n.a. V.A.Almazov

location_facility: Veterans Affairs San Diego Healthcare System

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: Institut Universitaire de Cardiologie et de Pneumologie de Québec

location_facility: 4th Wojskowy Szpital Kliniczny z Poliklinika, Klinika Kardiologii

location_facility: North Texas Healthcare System, Dept. of Veteran's Affairs

location_facility: Centre Hospitalier Universitaire de Sherbrooke

location_facility: Penza Regional Clinical Hospital n.a. N.N. Burdenko

location_facility: Hospital Clinic I Provincial de Barcelona

location_facility: Hospital Clínico Universitario Virgen de la Victoria

location_facility: Krankenhaus Der Barmherzigen Brüder Trier

location_facility: Complejo Hospitalario Universitario de Vigo, Meixoeiro Hospital

location_facility: University of Florida Health Sciences Center-Jacksonville

location_facility: A.R.N.A.S. Civico G. Di Cristina Benfratelli


title: A Study To Evaluate The Safety And Efficacy Of IPX066 In Advanced Parkinson's Disease

summary: This is a study to evaluate the safety and efficacy of IPX066 in advanced Parkinson's disease.

ReferenceCitation: Morgan JC, Dhall R, Rubens R, Khanna S, Gupta S. Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson's Disease with Motor Fluctuations. Parkinsons Dis. 2018 Oct 22;2018:9763057. doi: 10.1155/2018/9763057. eCollection 2018.

oa_colors: green gold

evidence: oa journal (via doaj)

repository_institution: Hindawi - Hindawi

repositories_concat: PubMed Central;hindawi.com

repositories_institution:
Hindawi - Hindawi
PubMed Central - Europe PMC

unpaywall_oa_status: gold

publisher_dissemination: Hindawi

ReferenceCitation: Hauser RA, Hsu A, Kell S, Espay AJ, Sethi K, Stacy M, Ondo W, O'Connell M, Gupta S; IPX066 ADVANCE-PD investigators. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson's disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol. 2013 Apr;12(4):346-56. doi: 10.1016/S1474-4422(13)70025-5. Epub 2013 Feb 26.

lead_sponsor: Impax Laboratories, LLC

location_country:
Germany
Poland
Romania
United States
Spain
Canada
Ukraine
France

location_facility:
Investigator 6
Investigator 37
Investigator 44
Investigator 36
Investigator 41
Investigator 9
Investigator 7
Investigator 71
Investigator 17
Investigator 16
Investigator 58
Investigator 15
Investigator 22
Investigator 53
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title: A Phase 2/3, Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Multicenter Protocol to Evaluate the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

acronym: GALAXI

summary: The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.

ReferenceCitation: Sandborn WJ, D'Haens GR, Reinisch W, Panes J, Chan D, Gonzalez S, Weisel K, Germinaro M, Frustaci ME, Yang Z, Adedokun OJ, Han C, Panaccione R, Hisamatsu T, Danese S, Rubin DT, Sands BE, Afzali A, Andrews JM, Feagan BG; GALAXI-1 Investigators. Guselkumab for the Treatment of Crohn's Disease: Induction Results From the Phase 2 GALAXI-1 Study. Gastroenterology. 2022 May;162(6):1650-1664.e8. doi: 10.1053/j.gastro.2022.01.047. Epub 2022 Feb 5. Erratum In: Gastroenterology. 2023 Dec;165(6):1588.

lead_sponsor: Janssen Research & Development, LLC

location_country:
Germany
Poland
Taiwan
New Zealand
Australia
Brazil
Japan
Bosnia and Herzegovina
Turkey
Croatia
Czechia
Canada
Serbia
France
Belarus
Lithuania
Colombia
Portugal
Slovakia
Hungary
United States
Latvia
Ukraine
North Macedonia
India
Tunisia
Lebanon
Belgium
China
Malaysia
Puerto Rico
Italy
United Kingdom
Netherlands
Austria
Korea, Republic of
Saudi Arabia
Spain
Greece
Jordan
Georgia
Russian Federation
Israel

location_facility: National Hospital Organization Kochi National Hospital

location_facility: Kitasato University Kitasato Institute Hospital

location_facility: Republican Research Centre of Radiation Medicine and Human E

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH

location_facility: Atlantic Digestive Health Institute/ Atlantic IBD Center

location_facility: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

location_facility: Twoja Przychodnia - Szczecinskie Centrum Medyczne

location_facility: ARS MEDICA Rybak Maria, Rybak Zbigniew, s.c.

location_facility: Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik

location_facility: NZOZ Vivamed Zespol Lekarzy Specjalistow

location_facility: MNCE'City Clinical Hospital №2 named after prof. O.O. Shalimov' of the Kharkiv City Council

location_facility: Synexus Polska Sp. z o.o. Oddzial w Warszawie

location_facility: JA Sapporo-Kosei General Hospital - 1st Digestive Organs

location_facility: The Military General Hospital of Beijing PLA

location_facility: Gastroenterology Associates of Tidewater

location_facility: Japan Community Health Care Organization Saitama Medical Center

location_facility: Hadassah Hebrew University Medical Center

location_facility: Groupement Hospitalier Universitaire Ouest

location_facility: KNP Kyivska miska klinichna likarnia №18 vykonavchoho orhanu KMR (KMDA)

location_facility: Healthcare Institution,Minsk Scientific center for surgery,

location_facility: MNCE Zakarpatska Regional Clinical Hospital named after A Novak of Zakarpatska Regional Council

location_facility: State Scientific Centre of Coloproctology

location_facility: Gastroenterologische Spezialpraxis - Berlin-Karlshorst

location_facility: Wojewodzki Szpital Specjalistyczny w Olsztynie

location_facility: Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

location_facility: University Hospital Kyoto Perfectural University of Medicine

location_facility: ZhuJiang Hospital of Southern Medical University

location_facility: Gastromed Spotka Z Ograniczona Odpowiedzialnoscia Sp. K.

location_facility: Mustafa Kemal University Research and Practise Hospital

location_facility: GASTROMED, Specjalistyczne Centrum Gastrologii i Endoskopii, Specjalistyczne Gabinety Lekarskie

location_facility: Tokitokai Tokito Clinic Coloproctology Center

location_facility: LLC Treatment and Diagnostic Center Adonis Plus

location_facility: Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio

location_facility: LTD Unimed Kakheti- Telavi Referral Hospital

location_facility: IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali

location_facility: Novgorod Regional Clinical Hospital n.a. N.A. Semashko

location_facility: Gastroenterologie und Hepatologie am Johannisplatz

location_facility: Academisch Medisch Centrum Universiteit van Amsterdam

location_facility: National Hospital Organization Osaka National Hospital

location_facility: Gastroenterology Research of America, LLC

location_facility: Gastroenterology and Internal Medicine Research Institute (GIRI)

location_facility: FSBI 'Scientific Research Institute of Clinical and Experimental Lymphology' of Siberian Branch

location_facility: Centrum Opieki Zdrowotnej Orkan-med Stec-Michalska sj

location_facility: Universita degli Studi di Padova - Azienda Ospedaliera di Padova

location_facility: The second Xiangya Hospital of Central South University

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie

location_facility: Shengjing Hospital of China Medical University

location_facility: Hopital Regional Mohamed Tahar El Maamouri

location_facility: The First Affiliated Hospital of Wenzhou Medical University

location_facility: The Hospital of Hyogo College of Medicine

location_facility: Corporacion para Estudios en Salud Clinica CES - Gastroenterology

location_facility: EuroMediCare Szpital Specjalistyczny z Przychodnia

location_facility: Centre Hospitalier Universitaire (CHU) de Caen

location_facility: Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway'

location_facility: Sun Yat-sen University - The Sixth Affiliated Hospital Guangdong Gastrointestinal Hospital

location_facility: The Limited Liability Company Research center Eco-safety

location_facility: Elite Research Network - Nature Coast Clinical Research, LLC

location_facility: Universidade Estadual Paulista 'Julio De Mesquita Filho'

location_facility: The First Affiliated Hospital of NanChang University

location_facility: Shiga University of Medical Science Hospital

location_facility: GBUZ of Moscow Region City Clinical Hospital #3

location_facility: NUZ 'Railway Clinical Hospital on Samara station of LLC 'Russian Railways'

location_facility: Clinical Hospital Center Bezanijska Kosa

location_facility: CHA Bundang Medical Center, CHA University

location_facility: King Abdullah Medical City in Holy Capital

location_facility: Huron Gastroenterology Associates Center for Digestive Care

location_facility: Vilnius University Hospital Santaros Klinikos, Public Institution

location_facility: National Hospital Organization Higashi Ohmi General Medical Center

location_facility: University Clinical Centre of the Republic of Srpska

location_facility: Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor

location_facility: Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska

location_facility: City Hospital named after St. Martyr Elizabeth

location_facility: Digestive Health Specialists of the Southeast

location_facility: The Catholic Univ. of Korea, DaeJeon St. Mary's Hospital

location_facility: Irmandade da Santa Casa da Misericórdia de Santos

location_facility: LSUHSC Shreveport Feist-Weiller Cancer Center

location_facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto - Hospital de Base

location_facility: Sisli Etfal Egitim ve Arastirma Hospital

location_facility: Universitaetsklinikum Salzburg - Landeskrankenhaus

location_facility: Pharmaceutical Integrated Research Company

location_facility: Ruijin Hospital, Shanghai Jiao Tong University

location_facility: Sociedade Campineira de Educacao e Instrucao - Hospital e Maternidade Celso Pierro

location_facility: Centro de Estudos Clínicos do Interior Paulista - CECIP

location_facility: Gastroenterology Consultants of Southwest Virginia

location_facility: University of Alberta- Ziedler Ledcor Centre

location_facility: The Catholic university of Korea, St. Vincent's Hospital

location_facility: 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie

location_facility: KZ Khersonska Miska Klinichna Likarnia Im. Ye.Ie.Karabelesha

location_facility: Synexus Polska Sp. z o.o. Oddzial w Czestochowie

location_facility: First Affiliated Hospital of Gannan Medical University

location_facility: LTD 'Georgia Archangel St. Michael Multiprofile Clinical Hospital'

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku

location_facility: Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud

location_facility: Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato

location_facility: The first affiliated hospital of suzhou University

location_facility: Clinical Hospital #122 n.a. after L.G. Sokolov

location_facility: National Hospital Organization Kyoto Medical Center

location_facility: Texas Gastroenterology Associates - Research

location_facility: SE 'National institute therapy named L.T. Maloi NAMS of Ukraine'

location_facility: Charlotte Gastroenterology and Hepatology, PLLC

location_facility: King Abdul Aziz Medical City for National Guard Health Affairs

location_facility: Surat Institute of Digestive Sciences Hospitals

location_facility: National Hospital Organization Kure Medical Center and Chugoku Cancer Center

location_facility: Inst Goiano Gastroenterologia e Endoscopia Digest Ltda - Clinica de Gastro

location_facility: St.Petersburg State Medical University n.a.Pavlov

location_facility: GBOU VPO Rostov State Medical University

location_facility: Clinical Research Institute of Michigan, LLC

location_facility: The First Affiliated Hospital Sun Yat-Sen University

location_facility: Gastroenterology Clinic Of San Antonio P A

location_facility: Zhangzhou Municipal Hospital of Fujian Province

location_facility: CEMEC - Centro Multidisciplinar de Estudos Clínicos

location_facility: Northwest Gastroenterology Associates - USA

location_facility: Synexus Polska Sp. z.o.o. Oddzial w Poznaniu

location_facility: CHRU de Strasbourg - Hopital de Hautepierre

location_facility: Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus

location_facility: University Clinic of Gastroenterohepatology

location_facility: Universitatsklinikum Schleswig Holstein Kiel

location_facility: St Georges Hospital university medical centre

location_facility: Policlinico S.Orsola Malpighi, AOU di Bologna

location_facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach

location_facility: H. Santo António - Centro Hospitalar do Porto

location_facility: Harmony Medical Research Institute, Inc.

location_facility: The 1st affiliated hospital of Anhui Medical University

location_facility: University North Carolina at Chapel Hill

location_facility: Gruppo Ospedaliero San Donato - Istituto di Ricovero e Cura

location_facility: Fundacao Universidade Federal do Piaui - Universidade Federal do Piaui

location_facility: American Universitty of Beirut Medical Center

location_facility: Special hospital for Internal diseases, Oncomed system

location_facility: The Second Affiliated Hospital of Zhejiang University

location_facility: Military Hospital of Instruction of Tunis

location_facility: The Second Affiliated Hospital of Chongqing Medical University

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: Kyongpook national university Medical center

location_facility: Seoul National University Bundang Hospital

location_facility: National Hospital Organization Hirosaki General Medical Center

location_facility: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

location_facility: Pauls Stradins Clinical University Hospital

location_facility: Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie

location_facility: Universitaetsklinikum Charite, Campus Virchow Klinikum

location_facility: Northshore Gastroenterology Research, LLC

location_facility: Second Military Medical University (SMMU)

location_facility: Hallym University Dongtan Sacred Heart Hospital

location_facility: Universidade Federal do Rio de Janeiro - Faculdade de Medicina

location_facility: Centro Hospitalar de Entre o Douro e Vouga, E.P.E

location_facility: Centro Hospitalar e Universitário de Coimbra, EPE

location_facility: Centre Hospitalier Universitaire de Reims, Hôpital Robert Debré

location_facility: Great Lakes Gastroenterology Research, LLC

location_facility: Azienda Ospedaliero Universitaria S.Maria Della Misericordia