summary:
This study will compare DS 8201a to standard treatment.

Participants must have HER2 breast cancer that has been treated before.

Their cancer:

cannot be removed by an operation
has spread to other parts of the body

ReferenceCitation: Andre F, Hee Park Y, Kim SB, Takano T, Im SA, Borges G, Lima JP, Aksoy S, Gavila Gregori J, De Laurentiis M, Bianchini G, Roylance R, Miyoshi Y, Armstrong A, Sinha R, Ruiz Borrego M, Lim E, Ettl J, Yerushalmi R, Zagouri F, Duhoux FP, Fehm T, Gambhire D, Cathcart J, Wu C, Chu C, Egorov A, Krop I. Trastuzumab deruxtecan versus treatment of physician's choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): a randomised, open-label, multicentre, phase 3 trial. Lancet. 2023 May 27;401(10390):1773-1785. doi: 10.1016/S0140-6736(23)00725-0. Epub 2023 Apr 20. Erratum In: Lancet. 2023 Dec 9;402(10418):2196.

oa_host_type: closed

location_facility: Hadassah University Hospital - Ein Kerem

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: Azienda Ospedaliera Città della Salute e della Scienza di Torino

location_facility: Istituto Nazionale Tumori Fondazione G. Pascale

location_facility: Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty

location_facility: Hospital de Especialidades de Jerez de la Frontera

location_facility: Adana Numune Training and Research Hospital

location_facility: Kapiolani Medical Center for Women and Children/Univ of HI

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: Hiroshima City Hiroshima Citizens Hospital

location_facility: Klinikum der Universitaet Muenchen - Campus Grosshardern

location_facility: Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital

location_facility: The Catholic University of Korea, St. Vincent's Hospital

location_facility: The University of Texas Health Science Center at Tyler

location_facility: Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

location_facility: Clinique Victor Hugo - Centre Jean Bernard

location_facility: Complejo Hospitalario Universitario A Coruña

location_facility: Hospital Universitario Clinico San Carlos

location_facility: Klinikum rechts der Isar der TU Muenchen

location_facility: Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

location_facility: CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie

location_facility: MultiCare Health System Institute for Research and Innovation

location_facility: AMO - Assistência Multidisciplinar em Oncologia

location_facility: Azienda Ospealiera della Provincia di Lecco

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital

location_facility: Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC

location_facility: North Shore Hematology Oncology Associates, PC

location_facility: Institut Régional du Cancer de Montpellier

location_facility: Kartal Lutfi Kirdar Research and Training Hospital

location_facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)

location_facility: Azienda Ospedaliera Ospedali Riuniti Papardo-Piemonte

location_facility: Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

location_facility: ICO Badalona - Hospital Universitari Germans Trias i Pujol

location_facility: CliniOnco - Tratamento Integrado do Câncer

location_facility: HGB - Hospital Giovanni Battista - Mãe de Deus Center

location_facility: IBCC - Instituto Brasileiro de Controle do Câncer

location_facility: General Oncology Hospital of Kifissia " Agioi Anargyroi"

location_facility: Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

location_facility: Smilow Cancer Hospital at Yale New Haven

location_facility: The Methodist Hospital Research Institute

location_facility: Sociedade Beneficiente de Senhoras Hospital Sírio Libanês

location_facility: Konya Necmettin Erbakan University Meram Faculty of Medicine

location_facility: Istanbul Medeniyet Uni Goztepe Training & Research Hospital

location_facility: University General Hospital of Heraklion

location_facility: St. Marianna University School of Medicine Hospital

location_facility: Kyungpook National University Chilgok Hospital

location_facility: Ankara Yildirim Beyazit Uni. Med. Fac.Ankara City Hospital

location_facility: Azienda Ospedaliero Universitaria Pisana

title: A Phase 3, Multicenter, Randomized, Open-label, Active-controlled Study of Trastuzumab Deruxtecan (DS-8201a), an Anti-HER2-antibody Drug Conjugate, Versus Treatment of Investigator's Choice for HER2-positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With T-DM1

ipd_sharing_description: De-identified individual participant data (IPD) on completed studies and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/

location_country:
Germany
Italy
Israel
United Kingdom
Australia
Brazil
Japan
Belgium
United States
Korea, Republic of
Spain
Greece
Turkey
Czechia
France


type: Other Identifier

type: EudraCT Number

title: A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

summary: The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.

study_start_date_type: Actual

status: Active, not recruiting

study_completion_date_type: Anticipated

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

ipd_sharing: Yes

ipd_sharing_description: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

lead_sponsor: Eli Lilly and Company

location_country:
Germany
Ireland
Poland
Argentina
Australia
Japan
Turkey
Croatia
Czechia
Canada
Serbia
France
Lithuania
Slovakia
Hungary
Denmark
Switzerland
United States
Latvia
Ukraine
India
Romania
Belgium
China
Malaysia
Italy
United Kingdom
Netherlands
Austria
Mexico
Korea, Republic of
Saudi Arabia
Spain
Taiwan
Russian Federation
Israel

location_facility: The Second Affiliated Hospital of Wenzhou Medical College

location_facility: The Affiliated Drum Tower Hospital of Nanjing University

location_facility: Kitasato University Kitasato Institute Hospital

location_facility: Tokushukai Sapporo Higashi Tokushukai Hospital

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej SONOMED

location_facility: No.1 Hospital Affiliated to Xinjiang Medical University

location_facility: University of Arizona, CATS Research Center

location_facility: Mautalen Salud e Investigacion-Centro de Osteopatías Médicas

location_facility: Gastroenterology Associates of Western Michigan, P.L.C.

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: Azienda Ospedaliero Universitaria San Martino

location_facility: Gastroenterology Associates of Pensacola, PA

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

location_facility: NYU Langone Long Island Clinical Research Associates

location_facility: King Faisal Specialist Hospital & Research Center

location_facility: Renji Hospital Affliated to Shanghai Jiaotong University

location_facility: Escorts Heart Institute and Research Centre Ltd

location_facility: The Gordon and Leslie Diamond Health Care Centre

location_facility: CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro

location_facility: Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.

location_facility: Private Small Enterprise, Medical Center Pulse

location_facility: Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2

location_facility: University of Texas Medical Branch at Galveston

location_facility: Poona Medical Foundation. Ruby Hall Clinic

location_facility: Institute of Digestive and Liver Diseases

location_facility: Twoja Przychodnia-Szczecinskie Centrum Medyczne

location_facility: Hospital Universitario Central de Asturias

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika

location_facility: Studiengesellschaft BSF Unternehmergesellschaft haftungsbeschraenkt

location_facility: Lviv Clinical Hospital at Railway Transport of Division Healthcare Center PJSC Ukrainian Railway Sta

location_facility: Moscow Budgetary State Healthcare Institution City Clinical Hospital 24

location_facility: Atlanta Gastroenterology Specialists, PC

location_facility: State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"

location_facility: KM Management spol. s r.o. Gastroenterologicke a hepatologicke centrum

location_facility: Kocaeli University Medical Faculty Hospital

location_facility: Centre Hospitalier de Wallonie picarde - CHwapi A.S.B.L.

location_facility: A. Novak Transcarpathian Regional Clinical Hospital

location_facility: Wake Forest University School of Medicine

location_facility: Showa University Northern Yokohama Hospital

location_facility: Irkutsk State Medical Academy of Continuing Education

location_facility: NZOZ ALL-MEDICUS, Zaklad Gastroenterologii

location_facility: Center Hospital of the National Center for Global Health and Medicine

location_facility: Indywidualna Specjalistyczna Praktyka Lekarska

location_facility: Saint Petersburg State Medical University n.a. Pavlov I.P.

location_facility: West Central Gastroenterology d/b/a Gastro Florida

location_facility: University of Massachusetts Medical Center

location_facility: The Catholic University of Daejeon St. Mary's Hospital

location_facility: Medical and Sanitary Division of Severstal

location_facility: Clinical Trials Center of Medical Institute

location_facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata

location_facility: Galilee Medical Center Department of Internal Medicine A

location_facility: Wojewodzki Specjalistyczny Szpital w Olsztynie

location_facility: Communal City Clinical Hospital of Ambulance

location_facility: Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"

location_facility: Azienda Ospedaliera Universitaria Pisana

location_facility: Care Access Research LLC - Salt Lake City

location_facility: Allen Whey Khye Lim Professional Corporation

location_facility: Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona Medicina Interna

location_facility: Gastro I s.r.o., Gastroenterologická ambulancia

location_facility: Melbourne Gastrointestinal Investigation Unit (MGIU)

location_facility: Tokyo Medical And Dental University Medical Hospital

location_facility: The University of Hong Kong-Shenzhen Hospital

location_facility: Centro de Investigaciones Metabólicas (CINME)

location_facility: Karelia Republican Hospital V.A. Baranova

location_facility: Azienda Ospedaliera Universitaria Careggi

location_facility: Kunming Medical College Affiliated First Hospital

location_facility: Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre

location_facility: Azienda ospedaliero-universitaria Mater Domini

location_facility: Jiangsu Province Hospital of Chinese Medicine

location_facility: Nanjing Medical University - Nanjing Jiangning Hospital

location_facility: Research Associates of South Florida, LLC

location_facility: Bangalore Medical College and Research Institute

location_facility: Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC

location_facility: Kyungpook National University Medical Center Chilgok Hospital

location_facility: Hospital Universitario Marques De Valdecilla

location_facility: Clinical Research of West Florida, Inc. (Clearwater)

location_facility: The First Hospital Affiliated to AMU (Southwest Hospital)

location_facility: The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA

location_facility: Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod

location_facility: Cotton-O'Neil Clinical Research Center, Digestive Health

location_facility: Gastroenterology Research of San Antonio

location_facility: Nizhegorodskiy Regional Clinical Hospital N.A.Semashko

location_facility: Praxis Balsiger, Seibold & Partner und Crohn-Colitis-Zentrum

location_facility: Communal Enterprise "Odesa Regional Clinical Hospital"

location_facility: Charité Universitätsmedizin Berlin Campus Buch

location_facility: Clinical Applications Laboratories, Inc.

location_facility: Xiangya Hospital Central South University

location_facility: The First Affiliated Hospital of Anhui Medical University

location_facility: Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen

location_facility: Communal Non-Commercial Enterprise of Lviv Regional Council Lviv Regional Clinical Hospital

location_facility: Apollo Research and Innovations, Apollo Hospitals International Ltd

location_facility: UMC Utrecht, Dept. of Internal Medicine, MDL

location_facility: Hospital Universitario Reina Sofia Comite Etico

location_facility: The Catholic University of Korea, St. Vincent's Hospital

location_facility: Digestive Health Specialists of the Southeast

location_facility: Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus

location_facility: DRC Gyogyszervizsgalo Rendelointezet Kft

location_facility: Shinseikai Sai Gastroenterology, proctology

location_facility: Centro de Investigación Clínica Acelerada

location_facility: Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

location_facility: Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital

location_facility: SBHI Regional Clinical Hospital #2 MoH of Krasnodar region

location_facility: Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -

location_facility: Centro Para el Desarrollo de la Medicina y de Asistencia Med

location_facility: Centrum Zdrowia Matki, Dziecka i Młodzieży (CZMDM) Przychodnie

location_facility: Delta Waves Sleep Disorders and Research Center

location_facility: The Center for Gastrointestinal Disorders

location_facility: Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica

location_facility: Ishida Clinic of IBD and Gastroenterology

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas

location_facility: Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation

location_facility: SBI of Healthcare of Leningrad region "Clinical Interregional Hospital of Tosno"

location_facility: LLC Scientific Research Centre EKO-Bezopasnost

location_facility: CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

location_facility: Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia

location_facility: Hopital de Hautepierre - Service d'Hépatogastroentérolgie

location_facility: Saint-Petersburg City Hospital of Saint Elizabeth

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology

location_facility: Endomed, s.r.o.- Gastroenterologicka ambulancia

location_facility: Center for Advanced Gastroenterology, PLLC

location_facility: Doctors Hospital at Renaissance Research Institute

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej

location_facility: Communal Institution "Poltava Reg.Cl.H. n.a.M.V.Sklifosovskogo"

location_facility: CHI Prof.O.O.Shalimov Kharkiv City Clinical Hospital #2

location_facility: Complexo Hospitalario Universitario A Coruña, CHUAC

location_facility: Pusat Penyelidikan Klinikal (CRC), Hospital Raja Perempuan Zainab II

location_facility: Instituto de Investigaciones Clinicas Quilmes

location_facility: The Second Hospital of Dalian Medical University

location_facility: First Affiliated Hosp of College of Med, Zhejiang University

location_facility: Clinical Research Institute of Michigan, LLC

location_facility: Soroka Medical Center - Pediatric Outpatient Clinic

location_facility: The Second Affiliated Hospital of Zhejiang University School of Med

location_facility: Multidisciplinary Medical Clinic "Anthurium"

location_facility: Pauls Stradins Kliniska Universitates Slimnica

location_facility: Clinical Center Kragujevac Gastroenterohepatology Clinic

location_facility: Pusat Perubatan University Kebangsaan Malaysia

location_facility: Univerzitna nemocnica Bratislava-Nemocnica Stare Mesteo

location_facility: The Sixth Affiliated Hospital, Sun Yat-Sen University

location_facility: Hospital Privado Centro Medico de Cordoba SA

location_facility: University of Oklahoma Health Sciences Center

location_facility: Yaroslavl Municipal HI Clinical Hospital #8

location_facility: Sankikai Yokohama Shin midori General Hospital

location_facility: The First People's Hospital of Yunnan Province

location_facility: Azienda Ospedaliera Universitaria Policlinico de Modena

location_facility: Vilnius University Hospital Santariskiu Clinics

location_facility: Ruijin Hospital Shanghai Jiaotong University School of Medicine

location_facility: Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine

location_facility: Toho University School of Medicine, Sakura Hospital

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital

location_facility: Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU

location_facility: Riga Eastern Clinical University Hospital

location_facility: Acibadem Universitesi - Acibadem Kozyatagi Hastanesi

location_facility: Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"

location_facility: CHU de Poitiers- Service d'Hépato-gastro-entérologie,

location_facility: Samodzielny Publiczny Szpital Kliniczny nr 4

location_facility: Centre de santé et de services sociaux Champlain-Charles-Le Moyne

location_facility: Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii

location_facility: Hacettepe University Faculty of Medicine

intervention_type: Drug

lead_sponsor_type: industriel

status_simplified: Ongoing


title: A Phase 4, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Chronic Migraine and Medication Overuse Headache

summary: Study 20170703 is a phase 4, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of erenumab against placebo in participants with chronic migraine (CM) who have a history of at least 1 preventive treatment failure and are diagnosed with medication overuse headache (MOH).

status: Completed

study_completion_date_type: Actual

ipd_sharing_description: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

lead_sponsor: Amgen

location_country:
Finland
Italy
Poland
Portugal
Hungary
United Kingdom
Australia
Austria
United States
Spain
Czechia
France

location_facility: Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz

location_facility: Centre Hospitalier Universitaire Saint-Etienne - Hopital Nord

location_facility: Azienda Ospedaliero Universitaria Mater Domini

location_facility: Michigan Head Pain and Neurological Institute

location_facility: Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Spolka Jawna

location_facility: Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz

location_facility: Jerzy Petz Mediq Niepubliczny Zaklad Opieki Zdrowotnej

location_facility: The George Washington Medical Faculty Associates

location_facility: Jahn Ferenc Del-pesti Korhaz es Rendelointezet

location_facility: Konventhospital der Barmherzigen Brueder Linz

location_facility: Universitaetsklinikum Allgemeines Krankenhaus Wien

location_facility: Hospital Clinico Universitario Lozano Blesa

location_facility: University of Miami Miller School of Medicine

location_facility: Hospital Professor Doutor Fernando Fonseca, EPE

location_facility: IRCCS Istituto delle Scienze Neurologiche di Bologna Ospedale Bellaria

location_facility: Hospital Universitari i Politecnic La Fe

location_facility: Centre Hospitalier Universitaire de Nice - Hopital de Cimiez

location_facility: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

location_facility: Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust

location_facility: Centre Hospitalier Regional Universitaire de Lille - Hopital Roger Salengro

location_facility: Azienda Ospedaliera Universitaria Careggi

location_facility: Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti Intezet

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Hospital Clinico Universitario de Valladolid

location_facility: Emerald Coast Center for Neurological Disorders

location_facility: Fondazione Istituto Neurologico Nazionale C Mondino IRCCS

location_facility: Hospices Civils de Lyon - Hopital neurologique Pierre Wertheimer

location_facility: Allegheny Health Network Cancer Institute at Mellon Pavilion

location_facility: Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria

location_facility: Clinical Trial Investigator Clinical Research Center

location_facility: Fondazione IRCCS Istituto Neurologico Carlo Besta

location_facility: Clinical Research Center Spzoo Medic-R Spolka Komandytowa

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

location_facility: Centre Hospitalier Universitaire de Poitiers

status_simplified: Completed


lead_sponsor: AstraZeneca

summary: The purpose of this study is to evaluate the safety and tolerability of MEDI8897 compared to palivizumab when administered to preterm infants entering their first RSV season and children with chronic lung disease (CLD) and congenital heart disease (CHD) entering their first and second RSV season.

ReferenceType: derived

ReferenceCitation: Domachowske J, Madhi SA, Simoes EAF, Atanasova V, Cabanas F, Furuno K, Garcia-Garcia ML, Grantina I, Nguyen KA, Brooks D, Chang Y, Leach A, Takas T, Yuan Y, Griffin MP, Mankad VS, Villafana T; MEDLEY Study Group. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med. 2022 Mar 3;386(9):892-894. doi: 10.1056/NEJMc2112186. No abstract available.

oa_host_type: publisher

evidence: open (via free article)

host_type: publisher

license_normalized: no license

version: publishedVersion

repositories_concat: closed

unpaywall_oa_status: bronze

publisher_dissemination: Massachusetts Medical Society

title: A Phase 2/3 Randomized, Double-blind, Palivizumab-controlled Study to Evaluate the Safety of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in High-risk Children (MEDLEY)

primary_purpose: Prevention

source: euctr

ipd_sharing_description: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

location_country:
Finland
Germany
Poland
New Zealand
Japan
Turkey
Czechia
Canada
France
Lithuania
Hungary
United States
Latvia
Ukraine
Belgium
Estonia
Italy
United Kingdom
Austria
Mexico
Korea, Republic of
Spain
South Africa
Bulgaria
Russian Federation
Sweden


title: A Phase II, Two-arm Study to Investigate Tepotinib Combined With Osimertinib in MET Amplified, Advanced or Metastatic NSCLC Harboring Activating EGFR Mutations and Having Acquired Resistance to Prior Osimertinib Therapy (INSIGHT 2)

summary: This study will assess the antitumor activity, safety, tolerability, and pharmacokinetics (PK) of the Mesenchymal-epithelial Transition Factor (MET) inhibitor tepotinib combined with the 3rd generation EGFR inhibitor osimertinib in participants with advanced or metastatic non-small cell lung cancer (NSCLC).

design_allocation: Non-Randomized

ReferenceType: background

ReferenceCitation: F Smit E, Dooms C, Raskin J, Nadal E, Tho LM, Le X, Mazieres J, S Hin H, Morise M, W Zhu V, Tan D, H Holmberg K, Ellers-Lenz B, Adrian S, Brutlach S, Schumacher KM, Karachaliou N, Wu YL. INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET-amplified NSCLC and first-line osimertinib resistance. Future Oncol. 2022 Mar;18(9):1039-1054. doi: 10.2217/fon-2021-1406. Epub 2021 Dec 17.

ipd_sharing_description: Per company policy, following approval of a new product or a new indication for an approved product in both the EU and the US, EMD Serono will share study protocols, anonymized patient level and study level data and redacted clinical study reports from clinical trials in patients with qualified scientific and medical researchers, upon request, as necessary for conducting legitimate research. Further information on how to request data can be found on our website https://www.emdgroup.com/en/research/our-approach-to-research-and-development/healthcare/clinical-trials/commitment-responsible-data-sharing.html

lead_sponsor: EMD Serono Research & Development Institute, Inc.

sponsor_collaborators: EMD Serono Research & Development Institute, Inc.

location_country:
Germany
Italy
Hong Kong
Singapore
Japan
Netherlands
Belgium
United States
China
Korea, Republic of
Spain
Malaysia
Thailand
Vietnam
Taiwan
Russian Federation
France

location_facility: Niigata Cancer Center Hospital - Dept of Internal Medicine

location_facility: Hopital Albert Calmette - CHU Lille - service de pneumologie et immuno allergologie

location_facility: Eastern Connecticut Hematology & Oncology Associates

location_facility: Sparrow Hospital Herbert - Herman Cancer Center

location_facility: ICO l´Hospitalet - Hospital Duran i Reynals - Servicio de Oncologia

location_facility: Ventura County Hematology Oncology Specialists

location_facility: Hamamatsu University School of Medicine, University Hospital - Dept of Respiratory Medicine

location_facility: Beacon International Specialist Centre Sdn Bhd

location_facility: Centre Francois Baclesse - Service d'Oncologie Medicale

location_facility: Azienda Socio Sanitaria Territoriale Sette Laghi (Presidio Ospedale di Circolo e Fondazione Macchi) - Oncologia Medica

location_facility: Hyogo College of Medicine Hospital - Dept of Respiratory Medicine

location_facility: Hospital Pulau Pinang - Clinic Respiratory

location_facility: ICO Badalona - Hospital Germans Trias i Pujol - Servicio de Oncologia Medica

location_facility: Medstar Franklin Square Clinical Research Center

location_facility: New Jersey Cancer Care and Blood Disorders

location_facility: Universitaetsklinikum Carl Gustav Carus TU Dresden

location_facility: BHI of Omsk region "Clinical Oncology Dispensary"

location_facility: Nagoya University Hospital - Dept of Respiratory Medicine

location_facility: The First Affiliated Hospital, Zhejiang University

location_facility: National Cancer Centre - Medical Oncology Pharmacy

location_facility: SBHI "Krasnoyarsk Regional Oncology Dispensary n.a. A.I. Kryzhanovsky"

location_facility: Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

location_facility: Hospital Universitari Son Espases - Servicio de Oncologia Medica

location_facility: Kanagawa Cancer Center - Dept of Respiratory Medicine

location_facility: Hospital Cochin Service, Service de Pneumologie et Mucoviscidose

location_facility: Hospital del Mar - Servicio de Oncologia

location_facility: Hospital Universitari Vall d'Hebron - Dept of Oncology

location_facility: University of Texas MD Anderson Cancer Center - Unit 432 Thoracic Head and Neck Medical Oncology

location_facility: Istituto Nazionale Tumori Regina Elena IRCCS - S.C. Oncologia Medica B

location_facility: Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen

location_facility: The Chinese University of Hong Kong - Emergency Medicine

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital

location_facility: Queen Elizabeth Hospital - Department of Medicine

location_facility: Maastricht University Medical Center - Dept of Medical Oncology

location_facility: Okayama University Hospital - Dept of Respiratory Medicine/Allergy

location_facility: The Center for Cancer & Blood Disorders - Maryland

location_facility: Oklahoma Cancer Specialists and Research Institute

location_facility: Hospital Universitario Virgen Macarena - Servicio de Oncologia

location_facility: Hospital Universitario Quiron Madrid - Unidad Integral de Oncologia

location_facility: Hospital Regional Universitario de Malaga

location_facility: Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) - U.O Oncologia Medica

location_facility: Centre Hospitalier Intercommunal de Créteil - Service de Pneumologie

location_facility: Weill Cornell Medical College - Gastroenterology

location_facility: Affiliated Tumor Hospital of Harbin Medical University

location_facility: Hospital Universitari Dexeus - Servicio de Oncologia Medica

location_facility: Fort Wayne Medical Oncology and Hematology

location_facility: Seoul National University Bundang Hospital

location_facility: Chonnam National University Hwasun Hospital

location_facility: Groupe Hospitalier Sud - Hôpital Haut-Lévêque - Maison du Ha

location_facility: CHU Limoges - Hôpital Dupuytren - Unite d'Oncologie Thoracique et Cutanée

location_facility: Asklepios Fachkliniken Muenchen-Gauting - Abteilung internistische Onkologie

location_facility: Hospital Universitario Materno-Infantil de Canarias - Servicio de Oncologia

location_facility: Pius-Hospital Oldenburg - Klinik f. Haematologie und Onkologie

location_facility: Hospital Universitari Quiron Dexeus - Servicio de Oncologia Medica

location_facility: Pavlov First Saint Petersburg State Medical University - Research Institute of Pulmunology

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology

location_facility: Boston Medical Center - Dept. Hematology/Oncology

location_facility: Azienda Ospedaliero Universitaria Pisana - U.O. Pneumologia II

location_facility: Hospital Universitari i Politecnic La Fe - Servicio de Oncologia Medica

location_facility: CHU de Toulouse - Hôpital Larrey - Service de Pneumologie et Oncologie Pneumologique

location_facility: IOV - Istituto Oncologico Veneto IRCCS - Oncologia Medica 2

location_facility: Universitair Medisch Centrum Groningen - Department of Internal Medicine

location_facility: Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma) - U.O.C. Oncologia

location_facility: FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov"

location_facility: AO Ospedali Riuniti Cervello - Presidio Villa Sofia - U.O.S. di Neuroimmunologia

location_facility: Tan Tock Seng Hospital - CTRU/OCS, Research

location_facility: Frederick Health- James M Stockman Cancer Institute

location_facility: Shanghai Cancer Hospital, Fudan University

location_facility: Universitaetsklinikum Koeln - Innere Medizin I, Onkologie, Haematologie

location_facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica

location_facility: Hematology Oncology Associates of Fredericksburg

location_facility: The Affiliated Cancer Hospital of Xinjiang Medical university

location_facility: Hospital Universitario HM Madrid Sanchinarro - Servicio de Oncologia

location_facility: Compassionate Care Research Group Inc - Edinger Medical Group, Inc.

location_facility: NYU Langone Clinical Cancer Center - NYU Langone Medical Center


title: A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome

acronym: AEGIS-II

summary: This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.

ipd_sharing: No

lead_sponsor: CSL Behring

location_country:
Finland
Germany
Poland
New Zealand
Argentina
Australia
Brazil
Japan
Thailand
Turkey
Croatia
Chile
Czechia
Canada
Serbia
France
Lithuania
Colombia
Portugal
Slovakia
Hungary
Hong Kong
Denmark
Switzerland
United States
Latvia
Ukraine
Romania
Belgium
Malaysia
Peru
Estonia
Italy
Norway
Singapore
United Kingdom
Sweden
Netherlands
Austria
Mexico
Korea, Republic of
Spain
Greece
South Africa
Taiwan
Bulgaria
Georgia
Russian Federation
Israel

location_facility: 8400379 - John Muir Health and Cardiovascular Institute

location_facility: 0760077 - Instituto de Pesquisa Clinica de Campinas

location_facility: 3800085 - Azienda Socio-Sanitaria Territoriale della Valle Olona

location_facility: 8401157 - Memorial Health University Medical Center

location_facility: 8400961 - Indiana Heart Physicians, Inc.

location_facility: 4100020 - Kyung Hee University Hospital at Gangdong

location_facility: 8400996 - Southern Arizona V.A. Healthcare System

location_facility: 8260055 - NHS National Waiting Times Centre Golden Jubilee National Hospital

location_facility: 2030061 - Oblastní nemocnice Náchod, a.s

location_facility: 1580009 - National Taiwan University Hospital

location_facility: 4840074 - Unidad de Investigación y Salud de Puebla S.C.

location_facility: 2330005 - North Estonia Medical Centre Foundation

location_facility: 8040016 - Lviv National Medical University named by Danylo Halitskyy

location_facility: 3800123 - AORN - Ospedali dei Colli Ospedale V. Monaldi

location_facility: 6160100 - Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii

location_facility: 6160061 - Wojewódzki Szpital Zespolony im. Ludwika Rydygiera w Toruniu

location_facility: 7920016 - Ankara Sehir Hastanesi Bilkent

location_facility: 8400610 - Jesse Brown V.A. Medical Center

location_facility: 6430048 - City Clinical Hospital No. 6 named after Karpovicha

location_facility: 2500112 - Centre Hospitalier Régional Universitaire de Lille (CHRU)

location_facility: 0320071 - Hospital Provincial del Centenario

location_facility: 3920114 - Toho University Ohashi Medical Center

location_facility: 0400031 - Universitatsklinik fuer Innere Medizin II, Kardiol

location_facility: 6420080 - Spitalul Clinic de Recuperare Cluj-Napoca

location_facility: 8260071 - Ashford and St Peter's Hospitals NHS Foundation Trust

location_facility: 7920012 - Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi

location_facility: 6160096 - 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie

location_facility: 2030057 - Fakultní Nemocnice Hradec Králové

location_facility: 8400916 - Southeastern Cardiology & Cardiovascular Clinic

location_facility: 4840008 - Hospital Civil de Guadalajara - Nuevo Hospital Civil de Guadalajara

location_facility: 6420060 - Spitalul Clinic Judetean de Urgenta Cluj-Napoca

location_facility: 8040017 - National Institute of Therapy named after L.T. Malaya NAMS o

location_facility: 6040056 - Instituto Nacional Cardiovascular - INCOR

location_facility: 0320017 - Entidades Vinculadas al Sanatorio Parque

location_facility: 4100016 - Veterans Health Service Medical Center

location_facility: 0760047 - Instituto de Cardiologia de Santa Catarina (ICSC)

location_facility: 2080020 - Hjertesygdomme | Regionshospitalerne i Viborg og Skive

location_facility: 1700006 - Hospital Universitario San Ignacio

location_facility: 1240063 - Heritage Medical Research Clinic

location_facility: 5280056 - Groene Hart Ziekenhuis - Gouda

location_facility: 3760035 - The Baruch Padeh Medical Center

location_facility: 7920015 - T.C. Saglik Bakanligi - Kartal Kosuyolu Yuksek Ihtisas Egitim

location_facility: 8400891 - John Muir Medical Center Walnu

location_facility: 0320029 - Instituto Cardiovascular de Buenos Aires

location_facility: 8040036 - Regional Medical Center for Cardiovascular Diseases

location_facility: 8400975 - Central Arkansas Veterans Healthcare System

location_facility: 8400572 - AtlantiCare Regional Medical Center

location_facility: 6420052 - Spitalul Judeţean de Urgenţă "Dr. Constantin Opriş" Baia Mar

location_facility: 8040010 - Dnipropetrovsk Medical Academy, Dnipropetrovsk Joint Emergen

location_facility: 8400693 - University of California Los Angeles

location_facility: 6880008 - Clinical Center of Serbia -- Division of Cardiology

location_facility: 7640010 - King Chulalongkorn Memorial Hospital

location_facility: 8400491 - Moses H. Cone Memorial Hospital

location_facility: 0760037 - Hospital de Messejana Dr. Carlos Alberto Gomes Studart

location_facility: 4100013 - Kyung Hee University Medical Center

location_facility: 6200026 - Centro Hospitalar do Baixo Vouga

location_facility: 0760011 - Hospital Cardiologico Costantini

location_facility: 8040008 - Kyiv City Clinical Hospital No. 1

location_facility: 1240093 - Halton Healthcare - Oakville Trafalgar Memorial Hospital

location_facility: 5280063 - Zuyderland Medisch Centrum, Heerlen

location_facility: 3920128 - Tokyo Bay Urayasu Ichikawa Medical Center

location_facility: 7520011 - Karolinska Universitetssjukhuset - Huddinge

location_facility: 4840007 - Unidad de Prevención y Atención Cardiometabólica (UPAC)

location_facility: 4840022 - Centro de Atencion e Investigacion Cardiovascular del Potosi

location_facility: 5280048 - Amphia Zienkenhuis - Locatie Molengracht Breda

location_facility: 8040032 - Ivano-Frankivskyy oblasnyy klinichnyy kardiologichnyy dyspan

location_facility: 8400551 - Cardiovascular Research of Knoxville

location_facility: 8400574 - Aurora Denver Cardiology Associates

location_facility: 1240062 - Saint Boniface General Hospital

location_facility: 8400667 - Michigan Cardiovascular Institute

location_facility: 6430079 - Scientific-Research Institute of Complex Problems of Cardio

location_facility: 8040009 - Kiev City Clinical Hospital No. 5

location_facility: 1910019 - Klinicki Bolnicki Centar Rijeka - Susak

location_facility: 1240081 - Saint Jerome Medical Research, Inc.

location_facility: 2080015 - Koege Sygehus - University Hospital Sjaelland

location_facility: 8400881 - North Texas Research Associates

location_facility: 2030041 - Nemocnice Pardubickeho kraje, a.s. - Pardubicka nemocnice

location_facility: 0320044 - Instituto Medico de la Fundacion de Estudios Clínicos

location_facility: 6160095 - Centrum Kardiologii Inwazyjnej i Angiologii w Krośnie

location_facility: 8400684 - UCHealth Memorial Hospital Central - Colorado Springs

location_facility: 5280042 - Elisabeth TweeSteden Ziekenhuis Vestiging Tilburg

location_facility: 2680026 - Georgian-Dutch Hospital MEDISON

location_facility: 6420046 - Spitalului Universitar de Urgenţă Militar Central "Dr. Carol Davila"

location_facility: 2030031 - Nemocnice Jablonec nad Nisou, p.o.

location_facility: 8400576 - IU Health Ball Memorial Hospital Physicians, Inc

location_facility: 8260066 - Torbay and South Devon NHS Foundation Trust - Torbay Hospital

location_facility: 6160051 - Krakowski Szpital Specjalistyczny im. Jana Pawła II

location_facility: 2760140 - Cardiologicum Hamburg - Studienzentrum

location_facility: 7920018 - Cukurova University School Of Medicine Balcali Hospital

location_facility: 0560022 - Centre Hospitalier Universitaire de Tivoli

location_facility: 6200021 - Centro Hospitalar do Alto Ave, EPE

location_facility: 6430060 - Regional State Budgetary Institution of Public Health

location_facility: 8401127 - Tulane University Health Science Center

location_facility: 6420053 - Spitalul Clinic Judetean de Urgenta Brasov

location_facility: 3760034 - Assaf Harofeh Medical Center - Cardiology Division

location_facility: 2500081 - CHU Besançon - Hôpital Jean Minjoz

location_facility: 6160063 - Klinika Kardiologii i Kardiochirurgii 10 WSK

location_facility: 5280038 - Admiraal de Ruijter Ziekenhuis - Locatie Goes

location_facility: 8040023 - Zhitomir Regional Clinical Hospital

location_facility: 8401144 - Saint Michael's Medical Center

location_facility: 8400504 - Integris Baptist Medical Center

location_facility: 8400889 - NC Heart and Vascular Research

location_facility: 1240078 - Kawartha Cardiology Clinical Trials

location_facility: 8400733 - Novant Health Heart and Vascular Institute

location_facility: 2500078 - Centre Hospitalier Louis Pasteur

location_facility: 2760193 - CardioVaskulares Centrum Frankfurt

location_facility: 8400854 - The Chattanooga Heart Institute

location_facility: 8400563 - Cardiovascular Institute of the South

location_facility: 8400626 - Montefiore Medical Center - Albert Einstein College of Medicine

location_facility: 2760168 - Klinikum Frankfurt Höchst GmbH

location_facility: 8400369 - HealthEast Saint Joseph's Hospital

location_facility: 3000022 - University of Athens - Hippokration General Hospital

location_facility: 3760026 - The Baruch Padeh Medical Center

location_facility: 7240035 - Complexo Hospitalario Universitario A Coruña

location_facility: 0320013 - Hospital Municipal de Coronel Suárez

location_facility: 8400544 - Cardiology Research Associates

location_facility: 2760111 - Klinikum der Stadt Ludwigshafen gGmbH

location_facility: 1580004 - Shin Kong Wu Ho-Su Memorial Hospital

location_facility: 7920017 - Eskişehir Osmangazi Üniversitesi Tıp Fakültesi

location_facility: 3000027 - GENERAL HOSPITAL Korgialenio - Benakio HRC

location_facility: 8400482 - Amarillo Heart Clinical Research Institute

location_facility: 5280031 - Meander Medisch Centrum - Locatie Amersfoort

location_facility: 1910003 - Klinicki Bolnicki Centar Zagreb

location_facility: 3480025 - Dombovari Szent Lukacs Egeszsegugyi Kft

location_facility: 2680004 - Clinical Cardology Institute Ltd.

location_facility: 4400004 - Hospital of Lithuanian University of Health Sciences - Kauno Klinikos

location_facility: 8400694 - University of California San Diego Medical Center

location_facility: 8040019 - Cherkasy Regional Cardiological Center

location_facility: 3920109 - National Hospital Organization Kumamoto Medical Center

location_facility: 0760061 - Hospital Universitario Maria Aparecida Pedrossian

location_facility: 2030073 - Karlovarska Krajska Nemocnice a.s.

location_facility: 8401103 - Orange Coast Memorial Hospital

location_facility: 1240058 - University of Alberta Hospital

location_facility: 5280060 - Ziekenhuis Rivierenland - Cardiologie

location_facility: 2680015 - Chapidze Emergency Cardiology Center

location_facility: 6430116 - City hospital # 2 "Sosnovaya roscha"

location_facility: 2080021 - Amager and Hvidovre Hospital - Medical Department

location_facility: 8400717 - V.A. Greater Los Angeles Healthcare System

location_facility: 6430072 - Samara Regional Cardiology Dispensary

location_facility: 8400862 - Cardiovascular Associates Research

location_facility: 8400836 - Our Lady of Lourdes Medical Center

location_facility: 1580002 - Kaohsiung Veterans General Hospital

location_facility: 8400357 - Saint Luke's Boise Medical Center

location_facility: 3480029 - Békés Megyei Pándy Kálmán Kórház

location_facility: 0760075 - Instituto D'Or de Pesquisa e Ensino

location_facility: 8401104 - Cardiovascular Institute of the South

location_facility: 8400557 - Clearwater Cardiovascular and Interventional Consultants

location_facility: 1000033 - University Multiprofile Hospital for Active Treatment

location_facility: 7020006 - National Heart Center Singapore

location_facility: 8400759 - Winchester Cardiology and Vascular Medicine

location_facility: 0560046 - AZ Groeninge - Campus Kennedylaan

location_facility: 6420057 - Institutul de Boli Cardiovasculare "Prof. Dr. George I. M. Georgescu

location_facility: 3480028 - Magyar Honvédség Egészségügyi Központ

location_facility: 8400745 - Hoag Memorial Hospital Presbyterian

location_facility: 4100015 - Pusan National University Yangsan Hospital

location_facility: 6040031 - Clínica Internacional - Sede San Borja

location_facility: 8401054 - Central Cardiology Medical Center

location_facility: 8400484 - Clearwater Cardiovascular and Interventional Consultants

location_facility: 8401178 - Jersey Shore University Medical Center Meridian Health

location_facility: 1000047 - University Hospital for Active Treatment & Emergency Medicine

location_facility: 5280058 - Universitair Medisch Centrum Utrecht

location_facility: 6880019 - KBC "Dr Dragiša Mišović-Dedinje"

location_facility: 8401011 - Cardiology Partners Research Institute

location_facility: 8400890 - Revival Research Institute, LLC

location_facility: 8400320 - Black Hills Cardiovascular Research

location_facility: 3800090 - Gruppo Ospedaliero San Donato - Policlinico San Marco

location_facility: 8401027 - UNC Hospitals Heart and Vascular Center at Meadowmont

location_facility: 1240092 - CHUM - Centre Hospitalier de l'Universite de Montreal

location_facility: 6160086 - Dept. of Interventional cardiology and Angiology, Institute

location_facility: 2500117 - Centre Chirurgical Marie Lannelongue

location_facility: 6160065 - III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokard

location_facility: 6430091 - City clinical hospital #15 n.a. O.M. Filatov

location_facility: 8400719 - V.A. San Diego Health Care System

location_facility: 8260065 - Milton Keynes Hospital NHS Foundation Trust

location_facility: 8401189 - Cardiovascular Associates of the Delaware Valley

location_facility: 8400677 - Saint Joseph's Hospital Cardiac Catheterization Associates

location_facility: 4840018 - Centro de Alta Especialidad Dr. Rafael Lucio

location_facility: 1700024 - Fundación Hospitalaria San Vicente de Paul

location_facility: 3800079 - Azienda Ospedaliera di Caserta "Sant'Anna e San Sebastiano"

location_facility: 8260058 - Royal Devon & Exeter NHS Foundation Trust

location_facility: 4400006 - Public Institution Republican Panevezys Hospital

location_facility: 8400861 - Ascension Providence Rochester Hospital

location_facility: 0320027 - Estudios Clínicos de los Arroyos

location_facility: 1520004 - Hospital Dr. Hernan Henriquez Aravena

location_facility: 6420090 - Spitalul Clinic de Urgenţă "Bagdasar-Arseni"

location_facility: 8400812 - Maine Medical Center Bramhall Campus

location_facility: 6430070 - Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine

location_facility: 8400613 - Jim Moran Heart and Vascular Center

location_facility: 3760037 - Tel Aviv University Sackler School of Medicine - Meir Medica

location_facility: 7030014 - Univerzitna Nemocnica Bratislava - Nemocnica sv. Cyrila a Me

location_facility: 8400625 - Michigan Heart and Vascular Institute

location_facility: 7920026 - Ondokuz Mayis Üniversitesi - Kardiyoloji Anabilim Dalı

location_facility: 1910013 - Klinički bolnički centar Sestre milosrdnice

location_facility: 7920032 - Kocaeli Universitesi Tip Fakultesi - Kardiyoloji Anabilim Dalı Başkanı

location_facility: 8400998 - Beth Israel Deaconess Medical Center

location_facility: 3760038 - Tel Aviv Sourasky Medical Center

location_facility: 8400334 - Cardiology Associates of North Mississippi

location_facility: 6430075 - First City Clinical Hospital named after E. E. Volosevich

location_facility: 0320037 - Centro Privado de Cardiologia (CPC)

location_facility: 7240068 - Hospital Universitario Marqués de Valdecilla

location_facility: 2030071 - Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha

location_facility: 2030040 - Oblastní Nemocnice Kladno, a.s.

location_facility: 7240050 - Hospital de la Santa Creu i Sant Pau

location_facility: 2760176 - Evangelisches Krankenhaus Witten

location_facility: 0560026 - Universitair Ziekenhuis Brussel

location_facility: 8400997 - CardioVascular Institute of North Colorado Cardiology Clinic

location_facility: 3480026 - Zala Megyei Szent Rafael Kórház

location_facility: 4840077 - Unidad de Investigacion en Salud (UIS)

location_facility: 2680027 - Tbilisi State Medical University (TSMU) - S. Khechinashvili

location_facility: 6420079 - Spitalul Clinic Judetean de Urgenta Sibiu

location_facility: 7920030 - T. C. Saglık Bakanlıgı - Bagcılar Egitim ve Arastırma Hastan

location_facility: 6160062 - Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Op

location_facility: 4580015 - Hospital Universiti Sains Malaysia

location_facility: 1000071 - University Multiprofile Hospital for Active Treatment "Dr. G"

location_facility: 6430081 - Saint Petersburg State Medical Academy

location_facility: 7920021 - Istanbul Universitesi Istanbul Tip Fakultesi

location_facility: 8400322 - Wake Forest University Health Sciences, Dept. of Cardiovascular Medicine

location_facility: 1700017 - Fundación Cardiovascular de Colombia

location_facility: 0320021 - Sanatorio Medico de Diagnostico y Tratamiento S.A.

location_facility: 8400661 - Norton Cardiovascular Associates

location_facility: 2760139 - Staedtisches Klinikum Dresden-Friedrichstadt - I. Medizinisc

location_facility: 1240066 - Centre Integre Universitaire de la Mauricie-et-du-Centre-du-Quebec

location_facility: 6430067 - Saratov State Medical University named after V.I. Razumovsky

location_facility: 6880023 - Kliničko Bolnički Centar Zvezdara

location_facility: 0760039 - Hospital Evangelico de Vila Velha (HEVV)

location_facility: 6420051 - Institutul Inimii "Niculae Stancioiu"

location_facility: 3920115 - Matsusaka Chuo General Hospital

location_facility: 1000072 - Multiprofile Hospital for Active Treatment - Dobrich AD

location_facility: 0760016 - Faculdade de Medicina de Sao Jose do Rio Preto-SP - Hospital

location_facility: 2760170 - Charite - UB - CVK - Medizinische Klinik

location_facility: 8400688 - George Washington University Medical Center

location_facility: 8400577 - Doylestown Cardiology Associates

location_facility: 3000026 - University General Hospital Attikon

location_facility: 1580001 - Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: 0320033 - Corporacion Medica de San Martin

location_facility: 7240030 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz

location_facility: 3480033 - Semmelweis University, Faculty of Medicine

location_facility: 7030006 - Univerzitna Nemocnica Bratislava - Nemocnica Staré Mesto

location_facility: 8400747 - Phoenix V.A. Health Care System

location_facility: 8401128 - Hillcrest Family Health Center

location_facility: 0760055 - Instituto Cardio Pulmonar da Bahia - Hospital

location_facility: 3920120 - National Cerebral and Cardiovascular Center

location_facility: 1000043 - Multiprofile Hospital for Active Treatment Blagoevgrad AD

location_facility: 6420049 - Spitalul Clinic Judetean de Urgenta Tîrgu - Mures

location_facility: 6430074 - St. Petersburg State Institution of Healthcare

location_facility: 4100017 - Chungnam National University Hospital

location_facility: 3000023 - National and Kapodistrian University of Athens (NKUA) - Scho

location_facility: 1000054 - Multiprofile Hospital for Active Treatment "National Cardiac Hospital"

location_facility: 4840016 - Instituto Nacional de Cardiologia Ignacio Chavez

location_facility: 8400485 - V.A. North Texas Health Care System

location_facility: 3760025 - Rabin Medical Center - Hasharon Hospital

location_facility: 6430068 - Regional Budgetary Healthcare Institution "Cardiology Dispensary"

location_facility: 4100014 - Yonsei University, Wonju Severance Christian Hospital

location_facility: 1700018 - Caja de Compensacion Familiar de Caldas

location_facility: 1000058 - Multiprofile Hospital for Active Treatment Plovdiv AD

location_facility: 8400746 - Penn Presbyterian Medical Center

location_facility: 8040037 - The Ivano-Frankivsk National Medical Univeristy

location_facility: 3920099 - Yokohama City University Medical Center

location_facility: 8400648 - Saint Luke's Cardiovascular Consultants

location_facility: 4840033 - Virgen Cardiovascular Research S.C.

location_facility: 4840020 - Centro de Estudios de Alta Especialidad de Sinaloa, S.C.

location_facility: 8400779 - MedStar Clinical Research Center

location_facility: 1240083 - CHU de Quebec-Universite-Laval, HDQ

location_facility: 8400910 - Cardiovascular Innovation and Research Center

location_facility: 0760081 - Hospital Universitário Cassiano Antonio Moraes (HUCAM)

location_facility: 4400005 - Vilnius University Hospital Santaros Klinikos

location_facility: 4840014 - Investigacion Biomedica para el Desarrollo de Farmacos S.A d

location_facility: 7920022 - Marmara Universitesi Tip Fakultesi

location_facility: 0320019 - Hospital Británico de Buenos Aires

location_facility: 7020005 - National University Hospital (S) Pte Ltd

location_facility: 0320041 - Clinica y Maternidad Suizo Argentina (CyMSA)

location_facility: 2460006 - Helsinki University Central Hospital (HUCH)

location_facility: 2500162 - CHRU de Tours - Hopital Trousseau

location_facility: 0400028 - Medizinische Universitaet Innsbruck - Universitaetsklinik für Innere Medizin

location_facility: 0560020 - AZ Sint-Jan Brugge-Oostende AV

location_facility: 2500092 - Centre Hospitalier Régional Metz-Thionville

location_facility: 7920025 - Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi - Kardiyo

location_facility: 8040048 - Communal Institution of Healthcare "Kharkiv Municipal Clinic

location_facility: 3000025 - University General Hospital of Patras

location_facility: 2680018 - TSMU - Alexandre Aladashvili University Clinic

location_facility: 6200018 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospitai

location_facility: 2500120 - Centre Hospitalier Annecy Genevois

location_facility: 8401233 - Cincinnati V.A. Medical Center

location_facility: 0320054 - Clínica Privada de Especialidades Médicas de Villa María

location_facility: 0560024 - Onze-Lieve-Vrouwziekenhuis VZW (OLV)

location_facility: 3480022 - University of Szeged - Second Department of Medicine & Cardiology Centre

location_facility: 3920093 - Miyazaki Medical Association Hospital

location_facility: 4580016 - University Malaya Medical Centre

location_facility: 3800087 - Azienda Ospedaliera Universitaria "Federico II"

location_facility: 6420044 - Spitalul Clinic Judetean de Ur

location_facility: 8401164 - University of Toledo Medical Center

location_facility: 2760130 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz

location_facility: 5280036 - Canisius-Wilhelmina Ziekenhuis

location_facility: 1000057 - Specialized Hospital for Active Treatment in Cardiology EAD

location_facility: 1240059 - Centre Hospitalier Pierre-Le Gardeur

location_facility: 2080022 - Amager Sygehus - Kardiologisk Klinik

location_facility: 1240113 - Niagara Health System, St. Catherines Site

location_facility: 0320069 - Hospital Italiano Regional del Sur

location_facility: 6200012 - Centro Hospitalar e Universitário do Algarve, EPE - Hospital

location_facility: 6430045 - Penza Regional Clinical Hospital n.a. N.N.Burdenko

location_facility: 0320073 - Instituto Medico De Alta Complejidad - IMAC

location_facility: 4840021 - Universidad Autonoma de Nuevo Leon - Hospital Universitario

location_facility: 6160083 - Wojewódzki Szpital Specjalistyczny im. Marii Skłodowskiej-Curie

location_facility: 7240064 - Hospital General Universitario de Alicante

location_facility: 7240045 - Hospital Universitario Ramón y Cajal

location_facility: 3800075 - ASST degli Spedali Civili di Brescia

location_facility: 2680013 - Tbilisi Heart and Vascular Clinic LTD

location_facility: 2030038 - Vseobecna Fakultni Nemocnice, Ustav hematologie a krevni transfuze

location_facility: 8260057 - Mid Essex Hospital Services NHS Trust - Broomfield Hospital

location_facility: 7640020 - Buddhachinaraj Hospital Phitsanuloke

location_facility: 1000035 - "MHAT "Sveta Anna"" - Sofia AD

location_facility: 3920106 - Hyogo Prefectural Amagasaki General Medical Center

location_facility: 2760164 - Elisabeth-Krankenhaus Essen GmbH Klinik für Kardiologie und Angiologie

location_facility: 3000016 - General Hospital of Thessaloniki "G. Papanikolaou"

location_facility: 2760190 - Asklepios Kliniken Hamburg GmbH

location_facility: 6430092 - Yaroslavl Regional Clinical Hospital

location_facility: 6430110 - SBHI of Novosibirsk Region "City Clinical Hospital of Emergency Care #2"

location_facility: 4580002 - Hospital Umum Sarawak (HUS) - The Cardiac Centre

location_facility: 8260099 - The Royal Wolverhampton NHS Trust - New Cross Hospital

location_facility: 8401175 - Overton Brooks V.A. Medical Center

location_facility: 6430064 - City Hospital for Emergency Care of Rostov-on-Don

location_facility: 2500091 - CHRU Montpellier - Arnaud de Villeneuve

location_facility: 0760012 - Instituto de Cardiologia do Rio Grande do Sul

location_facility: 8400570 - Advanced Cardiology Specialists

location_facility: 8040050 - Regional Clinical Hospital - Emergency Medical Care

location_facility: 6420048 - Spitalul Judetean de Urgenta Pitesti-Arges

location_facility: 3920121 - Hokkaido Cardiovascular Hospital

location_facility: 3480023 - Petz Aladar County Teaching Hospital

location_facility: 8040012 - Kharkiv City Clinical Hospital #8

location_facility: 6420059 - Institutul de Urgenta pentru Boli Cardiovasculare si Transplant

location_facility: 2030052 - Všeobecná fakultní nemocnice v Praze

location_facility: 0760052 - Hospital Nossa Senhora da Conceicao (HNSC)

location_facility: 3800082 - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

location_facility: 1240107 - Clinique de Cardiologie de Levis

location_facility: 7240032 - Hospital Universitari Joan XXIII de Tarragona

location_facility: 8260086 - Manchester University NHS Foundation Trust - Manchester Royal Infirmary

location_facility: 6200025 - Unidade Local de Saude de Matosinhos - Hospital Pedro Hispan

location_facility: 8040021 - Heart Institute of the Ministry of Health of Ukraine

location_facility: 1240106 - McGill University Health Centre (MUHC)

location_facility: 0320032 - Hospital Dr. Jose Maria Cullen

location_facility: 8400888 - Saint Jude Heritage Healthcare

location_facility: 8401000 - Advocate Lutheran General Hospital

location_facility: 4100025 - Korea University Anam Hospital

location_facility: 8400873 - Baptist Clinical Research Institute

location_facility: 6160082 - II Oddział Kardiologiczny PAKS

location_facility: 0760085 - Hospital Universitário São José (HUSJ)

location_facility: 6160093 - Specjalistyczny Szpital im. dr Alfreda Sokolowskiego

location_facility: 3800107 - Università degli Studi "Magna Graecia" di Catanzaro

location_facility: 2500107 - Centre Hospitalier Sud Francilien

location_facility: 7240077 - Hospital Universitari Arnau de Vilanova de Lleida

location_facility: 3800170 - Fondazione Poliambulanza Istituto Ospedaliero

location_facility: 0760036 - Hospital Geral Universitário de Cuiabá - HGU

location_facility: 2760184 - Praxis Dr. Med. Nicole Toursarkissian

location_facility: 0760009 - Santa Casa de Misericordia de Marilia

location_facility: 1700012 - Fundación Oftalmológica de Santander - Clinica FOSCAL

location_facility: 8260088 - Kettering General Hospital NHS Foundation Trust

location_facility: 6430115 - Pavlov First Saint Petersburg State Medical University

location_facility: 8401108 - University of Missouri Health System

location_facility: 3920119 - Ehime Prefectural Central Hospital

location_facility: 6420088 - Institutul Inimii "Niculae Stancioiu"

location_facility: 3920116 - Nihon University Itabashi Hospital

location_facility: 6420050 - Spitalul Universitar de Urgent

location_facility: 0760068 - Gutierrez Cardiologia Clinica e Intervencionista Ltda.

location_facility: 0760057 - Centro de Cardiologia Clinica e Pesquisa Dra. Juliana Souza

location_facility: 8400596 - Long Beach Memorial Medical Center

location_facility: 8400893 - Interventional Cardiology Medical Group

location_facility: 8400496 - Advanced Cardiology Associates

location_facility: 3920104 - Shizuoka City Shizuoka Hospital

location_facility: 4840004 - Hospital Cardiológica Aguascal

location_facility: 6880013 - General Hospital Sremska Mitrovica

location_facility: 8260102 - Queen Elizabeth Hospital Birmingham

location_facility: 2500042 - CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque

location_facility: 6430050 - Kursk City Emergency Care Hospital

location_facility: 7030002 - Svet zdravia, a.s. - Všeobecná nemocnica Rimavská Sobota

location_facility: 2760186 - Katholisches Klinikum Mainz - Klinik fuer Innere Medizin I

location_facility: 8400718 - V.A. Pittsburgh Healthcare System

location_facility: 6430107 - Clinical Hospital of the Russian Academy of Science

location_facility: 8400622 - Mercy Medical Research Institute

location_facility: 7240063 - Hospital Universitario Vall d'Hebron

location_facility: 1000045 - MHAT City Clinic - Sv. Georgi EOOD

location_facility: 4100021 - Chungbuk National University Hospital

location_facility: 1520014 - Hospital Clinico Regional Dr. Guillermo Grant Benavente

location_facility: 3000013 - University General Hospital of Thessaloniki AHEPA

location_facility: 3920123 - Tokyo Women's Medical University Hospital

location_facility: 6430049 - Pokrovskaya Municipal Hospital

location_facility: 3480040 - Jahn Ferenc Dél-pesti Kórház és Rendelőintézet

location_facility: 7100010 - Clinical Projects Research SA (Pty) Ltd.

location_facility: 4280005 - SIA Rigas Austrumu Kliniska Universitates Slimnica - Gaileze

location_facility: 0760027 - CEMEC - Centro Multidisciplinar de Estudos Clínicos

location_facility: 7240053 - Hospital Universitari de Bellvitge (IDIBELL)

location_facility: 3800106 - Università degli Studi di Roma "La Sapienza"

location_facility: 3480018 - Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintéz

location_facility: 6420071 - Institutului de Boli Cardiovasculare Timişoara

location_facility: 8400361 - Midwest Cardiovascular Research

location_facility: 1910008 - Specijalna Bolnica za Medicinsku Rehabilitaciju Krapinske Toplice

location_facility: 2680012 - Chapidze Emergency Cardiology Center

location_facility: 8400364 - Minneapolis Heart Institute Foundation

location_facility: 2030059 - Uherskohradišťská nemocnice a.s.

location_facility: 6430042 - Research Institute of Cardiology

location_facility: 4580008 - Universiti Kebangsaan Malaysia Medical Centre

location_facility: 7920014 - Mersin Üniversitesi Tip Fakültesi

location_facility: 3760029 - Hadassah Medical Center-Mount Scopus

location_facility: 8400543 - Cardiology Partners Research Institute

location_facility: 3480045 - Somogy Megyei Kaposi Mór Oktató Kórház

location_facility: 5780003 - Akershus Universitetssykehus HF

location_facility: 3480019 - Debreceni Egyetem Klinikai Központ

location_facility: 0560019 - Centre Hospitalier Régional de Huy

location_facility: 6200014 - Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Santa

location_facility: 4100008 - Seoul National University Hospital

location_facility: 4100022 - Hallym University Sacred Heart Hospital

location_facility: 8401141 - Western Michigan University Homer Striker MD School of Medicine

location_facility: 8401120 - Northeast Georgia Medical Center

location_facility: 1000024 - Multiprofile District Hospital

location_facility: 3000007 - General Hospital of Nikea "Agios Panteleimon"

location_facility: 3920094 - Juntendo University Shizuoka Hospital

location_facility: 4580005 - Universiti Teknologi MARA (UiTM)

location_facility: 2080019 - Sjaellands Universitetshospital - Kardiologisk Afdeling

location_facility: 6420083 - Institutului de Boli Cardiovasculare Timişoara

location_facility: 6200017 - Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Hospital

location_facility: 8400700 - Mercy Saint Vincent Medical Center

location_facility: 8400904 - Northeast Iowa Medical Education Foundation

location_facility: 3480035 - Tolna Megyei Balassa Janos Korhaz

location_facility: 6160080 - Regional Public Specialty Hospital "Latawiec"

location_facility: 1000053 - Multiprofile Hospital For Active Treatment - Pazardzhik AD

location_facility: 3920095 - Showa University Fujigaoka Hospital

location_facility: 1580010 - China Medical University Hospital

location_facility: 1000038 - Acibadem City Clinic University Hospital, EOOD

location_facility: 4100024 - Seoul National University Bundang Hospital

location_facility: 1580008 - Mackay Memorial Hospital - Tamsui Branch

location_facility: 8260093 - The London North West Healthcare NHS Trust - Northwick Park

location_facility: 8040013 - Khmelnytskyi Regional Hospital

location_facility: 8400735 - Parkway Cardiology Associates, PC

location_facility: 8400713 - University of South Alabama College of Medicine

location_facility: 1000044 - Second Multiprofile Hospital for Active Treatment - Sofia EA

location_facility: 2080016 - Medicinsk Afdeling - Herning Sygehus

location_facility: 3920133 - Kanagawa Cardiovascular and Respiratory Center

location_facility: 1240071 - Institut universitaire de cardiologie et de pneumologie de Quebec

location_facility: 3800110 - Fondazione IRCCS Policlinico San Matteo

location_facility: 4840006 - Centro para el Desarrollo de la Medicina y de Asistencia Méd

location_facility: 6880012 - Institute of Cardiovascular Diseases of Vojvodina

location_facility: 7240034 - Hospital Clinico Universitario de Valencia

location_facility: 2500105 - CHU de Nimes - Hopital Universitaire Caremeau

location_facility: 2500080 - CHU de Toulouse - Hopital Rangueil - Cardiologie

location_facility: 0760018 - Pronto Socorro Cardiológico de Pernambuco (PROCAPE)

location_facility: 8400863 - Swedish Medical Center - Providence Campus

location_facility: 2760146 - Innere Medizin I, Marienhaus Klinikum Eifel Bitburg

location_facility: 3920118 - Sapporo Medical University Hospital

location_facility: 7640018 - Maharat Nakhon Ratchasima Hospital

location_facility: 6430063 - Lyubertsy Regional Hospital No. 2

location_facility: 0760041 - Hospital e Maternidade Dr. Christovao da Gama

location_facility: 0560023 - Centre Hospitalier Universitaire Brugmann

location_facility: 7920023 - Ege Üniversitesi Tıp Fakültesi

location_facility: 3000029 - University of Thessaly- General University Hospital of Laris

location_facility: 0400034 - Klinikum Klagenfurt am Wörthersee

location_facility: 0560036 - Universitair Ziekenhuis Leuven

location_facility: 0760083 - Irmandade da Santa Casa de Misericordia de Sao Paulo

location_facility: 8260134 - The Newcastle upon Tyne Hospitals NHS Foundation Trust - Fre

location_facility: 7240070 - Hospital Universitario Virgen Arrixaca

location_facility: 8401010 - Integrative Research Associates Inc.

location_facility: 8040035 - Lviv Regional State Clinical-and-Diagnostic Cardiology Cente

location_facility: 4840003 - Centro de Estudios Clínicos de Querétaro, SC

location_facility: 5280054 - Noordwest Ziekenhuisgroep - Alkmaar

location_facility: 3800129 - Azienda Ospedaliero-Universitaria Careggi

location_facility: 7240043 - Hospital Universitario Fundación Alcorcón

location_facility: 6420045 - Spitalul Clinic Judeţean de Urgenţă Oradea

location_facility: 8040047 - Oleksandrivska Clinical Hospital

location_facility: 8401192 - South Orange County Surgical Medical Group

location_facility: 0760035 - Loema - Instituto de Pesquisa Clinica

location_facility: 8260101 - United Lincolnshire Hospitals NHS Trust - Lincoln County Hospital

location_facility: 8400921 - Mission Research Institute, LLC

location_facility: 6200022 - Centro Hospitalar e Universitário de Coimbra, EPE - Hospital

location_facility: 0760053 - Fundação Bahiana de Cardiologia

location_facility: 1240061 - SMH Cardiology Clinical Trials Inc.

location_facility: 2680002 - Helsicore - Israeli Georgian Medical Research Clinic

location_facility: 6880024 - Opsta Bolnica "Dorde Joanovic" Zrenjanin

location_facility: 6420047 - Spitalul de Urgenta "Sf. Ioan Cel Nou" Suceava

location_facility: 6430043 - Tula Regional Clinical Hospital

location_facility: 3480020 - Fejér Megyei Szent György Egyetemi Oktató Kórház

location_facility: 0760038 - Instituto de Cardiologia do Distrito Federal (ICDF)

location_facility: 4280008 - Pauls Stradins Clinical University Hospital

location_facility: 8400502 - Stroobants Cardiovascular Center

location_facility: 1700007 - Fundacion Cardiomet Eje Cafetero CEQUIN

location_facility: 4840025 - Hospital Central "Dr. Ignacio Morones Prieto"

location_facility: 8400517 - Shands Jacksonville Medical Center

location_facility: 1000070 - University Multiprofile Hospital for Active Treatment Alexa

location_facility: 3760018 - Leviev Heart Center, Chaim Sheba Medical Center

location_facility: 4840045 - OCA Hospital - Monterrey International Research Center

location_facility: 1000029 - Multiprofile Hospital for Active Treatment AD Haskovo

location_facility: 6420043 - Spitalul Universitar de Urgenta Bucuresti

location_facility: 8260043 - University Hospitals of Leicester NHS Trust - Glenfield

location_facility: 0760021 - Fundacao Hospitalar Sao Francisco de Assis

location_facility: 6880009 - Department of Cardiology, Clinical Center of Serbia and Belgrade

location_facility: 6160077 - Samodzielny Publiczny Zakład Opieki Zdrowotnej w Puławach

location_facility: 3440004 - Queen Elizabeth Hospital (QEH)

location_facility: 7920024 - Afyon Kocatepe University Medical Faculty Dept. Of Cardiology

location_facility: 2080014 - Svendborg Sygehus, Ward "Forskningsenheden Afd M Svendborg"

location_facility: 8400500 - Tennova Health Care - Turkey Creek Medical Center

location_facility: 6430047 - Novosibirsk Regional Clinical Hospital

location_facility: 2760147 - GPR Klinikum Rüsselsheim II - Medizinische Klinik Innere Medizin

location_facility: 4100010 - The Catholic University of Korea, St. Vincent's Hospital

location_facility: 0760034 - Hospital e Maternidade Celso Pierro

location_facility: 0320040 - Instituto de Cardiología de Corrientes

location_facility: 6160066 - IV Oddział Kardiologii Inwazyjnej, Elektrostymulacji i Angio

location_facility: 6430058 - State Budget Healthcare Institution of Novosibirsk Region "C

location_facility: 8400503 - The Heart and Vascular Center / Holy Family Memorial

location_facility: 8400638 - Mid Michigan Regional Medical Center

location_facility: 8401165 - Ascension Macomb-Oakland Hospital Warren Campus

location_facility: 6160078 - Nowy Szpital Uniwersytecki w Krakowie-Prokocimiu

location_facility: 3000010 - University Hospital of Ioannina

location_facility: 0760069 - Hospital Universitario Evangelico de Curitiba

location_facility: 0760040 - Santa Casa de Misericordia de Pelotas

location_facility: 8400507 - The Saint Vincent Heart Center of Indiana

location_facility: 8400847 - University of Rochester Medical Center-Strong Memorial Hospital

location_facility: 3000008 - University of Ioannina School of Medicine - Michaelidion Cardiac Center

location_facility: 1240090 - New Brunswick Heart Centre Research Initiative

location_facility: 2460011 - Turku University Hospital (TYKS)

location_facility: 2030020 - Fakultní nemocnice Královské Vinohrady

location_facility: 1240099 - Centre Hospital Saint Georges de Beauce

location_facility: 3920111 - Ishikawa Prefectural Central Hospital

intervention_type: Other


acronym: Canopy-A

lead_sponsor: Novartis Pharmaceuticals

summary: The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).

location_facility: Advanced Medical Specialties Drug Ship - 2

location_facility: Oncology and Hematology Associates of Southwest Virginia Inc

location_facility: VA Nebraska-Western Iowa Health Care System

location_facility: Rocky Mountain Cancer Centers Denver-Mdtn(Bone&MarrowTransp)

location_facility: VA Palo Alto Health Care System CRLX030A2301

location_facility: Rush University Medical Center CLDT600AUS06

location_facility: Louis Stokes Cleveland Department of Veterans Affairs MC

location_facility: Virginia Cancer Specialists Fairfax Northern Virginia

location_facility: Cancer Center of Kansas Dept.ofCancerCtr.ofKansas

location_facility: Chattanooga Oncology and Hematology Associates PC Chattanooga Oncology

status: Terminated

title: A Phase III, Multicenter, Randomized, Double Blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Canakinumab Versus Placebo as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II -IIIA and IIIB (T>5cm N2) Completely Resected (R0) Non-small Cell Lung Cancer (NSCLC)

ipd_sharing_description:
Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent expert panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations.

This trial data will be available according to the process described on www.clinicalstudydatarequest.com.

location_country:
Germany
Poland
Taiwan
Argentina
Japan
Brazil
Thailand
Vietnam
Turkey
Chile
Czechia
Canada
France
Slovenia
Colombia
Portugal
Hungary
Hong Kong
Switzerland
United States
Iceland
India
Romania
Lebanon
China
Malaysia
Peru
Philippines
Italy
Norway
United Kingdom
Austria
Korea, Republic of
Spain
Greece
Panama
Jordan
Bulgaria
Georgia
Russian Federation
Israel

status_simplified: Unknown


title: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial Comparing CB-839 in Combination With Cabozantinib (CB-Cabo) vs. Placebo With Cabozantinib (Pbo-Cabo) in Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC)

acronym: CANTATA

summary: Tthe primary objective of this study is to compare blinded Independent Radiology Committee (IRC)-adjudicated progression free survival (PFS) of patients treated with CB-839 + cabozantinib (CB-Cabo) versus placebo + cabozantinib (Pbo-Cabo) for advanced or metastatic clear-cell RCC (ccRCC).

ReferenceCitation: Tannir NM, Agarwal N, Porta C, Lawrence NJ, Motzer R, McGregor B, Lee RJ, Jain RK, Davis N, Appleman LJ, Goodman O Jr, Stadler WM, Gandhi S, Geynisman DM, Iacovelli R, Mellado B, Sepulveda Sanchez JM, Figlin R, Powles T, Akella L, Orford K, Escudier B. Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial. JAMA Oncol. 2022 Oct 1;8(10):1411-1418. doi: 10.1001/jamaoncol.2022.3511.

oa_host_type: repository

evidence: oa repository (via pmcid lookup)

host_type: repository

repository_normalized: PubMed Central

repositories_concat: PubMed Central

unpaywall_oa_status: green

publisher_dissemination: American Medical Association

lead_sponsor: Calithera Biosciences, Inc

location_country:
Germany
Italy
New Zealand
United Kingdom
Australia
United States
Spain
France

location_facility: North Shore Hematology Oncology Associates PC dba NY Cancer and Blood Specialists

location_facility: Northwestern Medicine Cancer Center Warrenville

location_facility: Azienda Ospedaliero Universitaria San Luigi Gonzaga

location_facility: Technischen Universitat München - Urologische Klinik

location_facility: El Hospital Clínic i Provincial de Barcelona (HCPB)

location_facility: Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: Salinas Valley Memorial Healthcare System

location_facility: St. Luke's Mountain States Tumor Institute

location_facility: H.Lee Moffitt Cancer & Research Institute (Moffitt Cancer Center)

location_facility: Universitätsklinikum Essen (AöR) Westdeutsches Tumorzentrum

location_facility: St. Bartholomew's Hospital, Barts Health NHS Trust

location_facility: The Center for Cancer and Blood Disorders

location_facility: Sarah Cannon Research Institute UK Limited

location_facility: Medical University Heidelberg, NCT (National Center for Tumour Diseases), Medical Oncology

location_facility: Unità Operativa (UO) di Oncologia Medica - ICS Maugeri

location_facility: CHU de Strasbourg (Les Hôpitaux Universitaires de Strasbourg)

location_facility: University of Miami Sylvester Comprehensive Cancer Center

location_facility: Nottingham University Hospitals NHS Trust - City Hospital Campus

location_facility: IUCTO Bureau des Essais Cliniques (Institut Claudius Regaud)

location_facility: Hôpital Européen Georges-Pompidou (HEGP)

location_facility: Hospital Universitari VHIO - Vall d'Hebron Departamento de Oncologia

location_facility: INTEGRIS Cancer Institute of Oklahoma Proton Campus

location_facility: Southern Highlands Private Hospital (Cancer Centre)

location_facility: Hospital Universitario Virgen de Macarena

location_facility: Institut Català d'Oncologia (ICO) L'Hospitalet

location_facility: University of Maryland, Greenebaum Comprehensive Cancer Center

location_facility: Istituto Europeo di Oncologia - Divisione di Oncologia Medica Urogenitale e Cervico Facciale

location_facility: Institut de Cancérologie de l'Ouest (ICO) - Centre René Gauducheau

location_facility: Centro Integral Oncologico Clara Campal (CIOCC) HM

location_facility: Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Klinik und Poliklinik

location_facility: University of Utah, Huntsman Cancer Institute

location_facility: U.O.C. ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo

location_facility: Universitätsklinikum Tübingen, Klinik für Urologie

location_facility: Mater Misericordiae Limited - Division of Cancer Services

location_facility: Centre hospitalier universitaire (CHU) Henri-Mondor

location_facility: S.C. Oncologia - ASST Cremona P.O. Ospedale di Cremona

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: Presidio Ospedaliero Antonio Perrino - U.O.C. Oncologia Medica

location_facility: Georgia Cancer Center at Augusta University

location_facility: Penrose Cancer Center, Research Department

location_facility: Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

location_facility: Institut Paoli-Calmettes Service d'Urologie

location_facility: HealthPartners Institute, Regions Cancer Care Center

location_facility: Policlinico Universitario Campus Bio-Medico

location_facility: U.O. Oncologia Ospedale degli Infermi - Dipartimento di Oncologia ed Ematologia

location_facility: Institut de Cancérologie de Montpellier (ICM)

location_facility: University of Mississippi Medical Center

location_facility: Institut Gustave Roussy - Le département de Medecine oncologique

location_facility: University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center

location_facility: Centre hospitalier régional universitaire (CHRU) de Besançon - Jean-Minjoz

location_facility: Fundación Instituto Valencia d'Oncología (IVO)

location_facility: AMITA Health Cancer Institute & Outpatient Center

location_facility: University of Modena and Reggio Emilia (Azienda Ospedaliera-Universitaria Policlinico Modena)

location_facility: Charité Universitätsmedizin Berlin, Dept. of Interdisciplinary Urology

location_facility: Froedtert Hospital and the Medical College of Wisconsin


type: Registry Identifier

title: Prospective Non Interventional Study of Cabozantinib Tablets in Adults With Advanced Renal Cell Carcinoma Following Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Therapy

acronym: CASSIOPE

summary: The objective of this study is to understand the utilization of cabozantinib in subjects with advanced renal cell carcinoma (RCC) following prior VEGF-targeted therapy in real life settings in terms of dose modifications due to adverse events (AEs) when used as a second line therapy or third and later line therapy. Other patterns of use of cabozantinib will also be described.

study_type: Observational

time_perspective: Prospective

lead_sponsor: Ipsen

location_country:
Germany
Italy
Poland
United Kingdom
Netherlands
Austria
Belgium
Spain
Greece
Czechia
France

location_facility: Complejo Hospitalario Universitario de Compostela

location_facility: Krajská Nemocnice Liberec, A.S., Komplexní Onkologické Centrum

location_facility: Thomayerova Nemocnice, Onkologická Klinika 1. LF UK A TN

location_facility: Dep. Medical Oncology, University Hospital of Ioannina

location_facility: Azienda Ospedaliero-Universitaria di Parma

location_facility: Universitaetsklinikum Frankfurt - Department of Urology

location_facility: East Kent Hospitals University NHS Foundation Trust

location_facility: University Medical Center LMU Munich - Campus Grosshadern, Urologische Klinik und Poliklinik Marchionnish R. 15

location_facility: Hospital Universitario Central de Asturias (Huca)

location_facility: Szpital Kliniczny Przemienienia Panskiego w Poznaniu

location_facility: Azienda Ospedaliera Universitaria Integrata Verona

location_facility: Hospital Clinico Lozano Blesa de Zaragoza

location_facility: Fakultni Nemocnice Kralovske Vinohrady (FNKV) - Radioterapeuticka a Onkologicka klinika

location_facility: Institut de Cancérologie Lucien Neuwirth (ICLN)

location_facility: Fondazione IRCCS Istituto Nazionale Dei Tumori

location_facility: Azienda Ospedaliero Universitaria di Modena

location_facility: Dept of Urology, Eberhard-Karls-University Tuebingen

location_facility: Wojskowy Instytut Medyczny, Klinika Onkologii

location_facility: Centre de Lutte Contre le Cancer (CLCC) - Institut Jean Godinot

location_facility: Mount Vernon Cancer Centre - East and North Hertfordshire NHS Trust

location_facility: Fondazione Salvatore Maugeri - I.R.C.C.S

location_facility: Universitatsklinikum fur Urologie und Andrologie

location_facility: University Medical Center Hamburg-Eppendorf

location_facility: Frimley Health NHS Foundation Trust - Wezham Park and Heatherwood Hospitals

location_facility: Azienda Ospedaliera S.Orsola Malpighi di Bologna

location_facility: Freeman Hospital-Northern Centre For Cancer Care

location_facility: UOC Oncologia Azienda Ospedaliera Sant-Andrea

location_facility: Rosemere Cancer Centre, Royal Preston Hospital

location_facility: National Cancer Institute "Fondazione G. Pascale" IRCCS

location_facility: Fakultni Nemocnice na Bulovce, Institut of Radiation Oncology


summary: A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab and bevacizumab therapy in patients with locoregional hepatocellular carcinoma

ReferenceCitation: Kloeckner R, Galle PR, Bruix J. Local and Regional Therapies for Hepatocellular Carcinoma. Hepatology. 2021 Jan;73 Suppl 1:137-149. doi: 10.1002/hep.31424. Epub 2020 Nov 6. No abstract available.

publisher_dissemination: Wolters Kluwer Health

title: A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination With Either Durvalumab Monotherapy or Durvalumab Plus Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-1)

location_country:
Italy
India
Hong Kong
Singapore
Australia
Brazil
Japan
Mexico
United States
China
Korea, Republic of
Spain
Thailand
Vietnam
Taiwan
Canada
Russian Federation
France


lead_sponsor: Pfizer

summary: This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.

ReferenceCitation: Agarwal N, Azad A, Shore ND, Carles J, Fay AP, Dunshee C, Karsh LI, Paccagnella ML, Santo ND, Elmeliegy M, Lin X, Czibere A, Fizazi K. Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: TALAPRO-2 phase III study design. Future Oncol. 2022 Feb;18(4):425-436. doi: 10.2217/fon-2021-0811. Epub 2022 Jan 26.

evidence: open (via page says license)

license: cc-by-nc-nd

license_normalized: cc-by-nc-nd

unpaywall_oa_status: hybrid

publisher_dissemination: Future Science Ltd

sponsor_collaborators:
Pfizer
Astellas Pharma Inc

location_facility: Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School

location_facility: AMITA Health Adventist Medical Center Hinsdale

location_facility: Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA

location_facility: Sociedad de Investigaciones Medicas Ltda (SIM)

location_facility: Hirosaki University School of Medicine & Hospital

location_facility: University of Colorado Hospital - Anschutz Cancer Pavilion

location_facility: Cancercare Langenhoven Drive Oncology Centre

location_facility: Fundacao Pio XII - Hospital de Cancer de Barretos

location_facility: Centre integre universitaire de sante et de services sociaux de l'Estrie

location_facility: University of California, Irvine Medical Center

location_facility: Peking University First Hospital / Urology Department

location_facility: Instituto do Cancer do Estado de Sao Paulo - ICESP

location_facility: UPMC Hillman Cancer Center - Monroeville

location_facility: Azienda Ospedaliero-Universitaria Policlinico Sant' Orsola Malpighi

location_facility: Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. Markiewicza

location_facility: Desert Hematology Oncology Medical Group, Incorporation

location_facility: Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii i Radioterapii

location_facility: Inova Schar Cancer Institute Infusion Pharmacy

location_facility: Tom Baker Cancer Centre - Alberta Health Services

location_facility: The Clatterbridge Cancer Centre NHS Foundation Trust

location_facility: The Clatterbridge Cancer Centre - Liverpool

location_facility: CHUM - Centre Hospitalier de l'Universite de Montreal

location_facility: TriState urologic Services PSC Inc., dba The Urology Group

location_facility: University of Colorado Hospital- Anschutz Inpatient Pavilion

location_facility: Centro Hospitalar do Porto - Hospital de Santo Antonio

location_facility: Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" Cemic

location_facility: Centro de Investigacion Pergamino SA - Clinica Pergamino SA

location_facility: Hospital Universitario Virgen de la Arrixaca

location_facility: Centro de Pesquisa Clinica em Oncologia - Hospital Sao Lucas da Pontificia Universidade Catolica

location_facility: The First Affiliated Hospital of Xi'an Jiaotong University

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

location_facility: Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

location_facility: Lakeland Regional Health Hollis Cancer Center

location_facility: Montefiore Medical Center - Montefiore Medical Park

location_facility: Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Clinical Trial Site

location_facility: AdventHealth Medical Group Hematology & Oncology at Celebration

location_facility: Corporacio Sanitaria i Universitaria Parc Tauli

location_facility: Farmington Health Center -University of Utah

location_facility: Providence Oncology and Hematology Care Clinic - Westside

location_facility: University of Wisconsin Hospital & Clinics

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: Oslo University Hospital -Ullevål & Radiumhospitalet

location_facility: The First Affiliated Hospital of Wenzhou Medical University

location_facility: UPMC Hillman Cancer Center - Arnold Palmer - Mt View

location_facility: Clinique Victor Hugo-Centre Jean Bernard

location_facility: The First People's Hospital of Lianyungang

location_facility: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

location_facility: NZOZ Szpital Mazovia; Oddzial urologiczny

location_facility: Instituto do Cancer do Estado de Sao Paulo-ICESP-Nucleo de Pesquisa

location_facility: Centro Gaucho Integrado - Hospital Mae de Deus

location_facility: Centro de Investigaciones Clinicas Vina del Mar

location_facility: Sharp Memorial Hospital Investigational Pharmacy

location_facility: Hospital Militar Central "Coronel Luis Arias Schreiber"

location_facility: The Second Hospital of Tianjin Medical University

location_facility: National Hospital Organization Kumamoto Medical Center

location_facility: UPMC Hillman Cancer Center - Passavant (OHA)

location_facility: The Fifth People's Hospital of Shanghai, Fudan University

location_facility: Baylor Scott & White Medical Center - Temple

location_facility: Associated Medical Professionals of New York, PLLC

location_facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

location_facility: Providence Cancer Institute Franz Clinic

location_facility: Instituto Português de Oncologia do Porto Francisco Gentil

location_facility: John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy

location_facility: Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers

location_facility: National Hospital Organization Hokkaido Cancer Center

location_facility: Faculdade de Medicina do ABC - Centro de Estudos e Pesquisa de Hematologia e Oncologia (CEPHO)

location_facility: Investigational Drug Services, Advent Health Orlando

location_facility: National Hospital Organization Tokyo Medical Center

location_facility: The University of Kansas Clinical Research Center

location_facility: UPMC Hillman Cancer Center - Passavant (HOA)

location_facility: Union Hospital, Tongji Medical College of Huazhong University of Science & Technology

location_facility: Redwood Health Center-University of Utah

location_facility: Institut Catala d'Oncologia - ICO L'Hospitalet

location_facility: National Hospital Organization Shikoku Cancer Center

location_facility: Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - Napoli

location_facility: Hospital Clinico Universitario de Santiago de Compostela

location_facility: First Affiliated Hospital of Xiamen University

location_facility: Hopitaux Universitaires de Strasbourg - ICANS

location_facility: University of Wisconsin Clinical Science Center

location_facility: Cancer Center Clinical Trial, Asan Medical Center

location_facility: Hospital Privado Centro Medico de Cordoba

location_facility: South Jordan Health Center -University of Utah

location_facility: Hamamatsu University School of Medicine, University Hospital

location_facility: West China Hospital of Sichuan University

location_facility: University of Colorado Hospital- Anschutz Outpatient Pavilion

location_facility: Kyungpook National University Chilgok Hospital

location_facility: Fudan University Cancer Hospital, Deptartment of Urology

location_facility: Vanderbuilt University Medical Center, Department of Urology

location_facility: Premier Medical Group of the Hudson Valley PC

location_facility: Providence Cancer Institute Willamette Falls

location_facility: National Hospital Organization Kure Medical Center and Chugoku Cancer Center

location_facility: Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean

location_facility: Centro Clínico Académico - Braga, Associação (2CABraga)

location_facility: The First affiliated Hospital of Anhui Medical University

location_facility: AdventHealth Medical Group Hematology & Oncology at Kissimmee

location_facility: Providence Cancer Institute Clackamas Clinic

location_facility: New Jersey Cancer Care and Blood Disorders

location_facility: Sociedade Beneficencia e Caridade de Lajeado - Hospital Bruno Born

location_facility: Hospital Nossa Senhora da Conceicao - Grupo Hospitalar Conceicao

location_facility: The First Affiliated Hospital of Nanchang University

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital

location_facility: Clinical Trial Pharmacy, The Catholic University of Korea

location_facility: Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Oncologia (CEPHO)

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: Second Affiliated Hospital of Suzhou University

location_facility: Sociedad Prosalud Montes y Orlandi Ltda. Fantasy name (Orlandi Oncologia)

location_facility: Imperial College Healthcare NHS Trust, Charing Cross Hospital

location_facility: Instituto Português Oncologia de Coimbra Francisco Gentil - E.P.E

location_facility: Providence Cancer Institute Newberg Clinic

location_facility: University of Utah, Huntsman Cancer Institute

location_facility: Clinical Trial Pharmacy, National Cancer Center

location_facility: Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intezet

location_facility: Przychodnia Lekarska "Komed" Roman Karaszewski

location_facility: Loma Linda University Cancer Center - Hematology/Oncology Clinic

location_facility: St. Olavs Hospital, Trondheim University Hospital

location_facility: Integrated Clinical Oncology Network Pty Ltd (ICON)

location_facility: Alaska Urological Institute dba Alaska Clinical Research Center

location_facility: UPMC Hillman Cancer Center - Upper St. Clair

location_facility: Hospital Universitario Pedro Ernesto-Centro de Pesquisas (CEPUSA)

location_facility: Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina

location_facility: The First Affiliated Hospital Of Fujian Medical University

location_facility: GU Research Network/Urology Cancer Center

title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

ipd_sharing_description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

location_country:
Finland
Germany
Poland
New Zealand
Argentina
Australia
Brazil
Japan
Chile
Czechia
Canada
France
Portugal
Hungary
United States
Belgium
China
Peru
Italy
Norway
United Kingdom
Sweden
Korea, Republic of
Spain
South Africa
Israel