summary: This is a Phase 2 trial that will evaluate the safety and efficacy of PF-02341066 in patients with advanced non-small cell lung cancer with a specific gene profile involving the ALK gene. This trial will also allow patients from a Phase 3 trial who received standard of care chemotherapy (Study A8081007) to receive PF-02341066.

ReferenceCitation: Blackhall F, Ross Camidge D, Shaw AT, Soria JC, Solomon BJ, Mok T, Hirsh V, Janne PA, Shi Y, Yang PC, Pas T, Hida T, Carpeno JC, Lanzalone S, Polli A, Iyer S, Reisman A, Wilner KD, Kim DW. Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer. ESMO Open. 2017 Aug 17;2(3):e000219. doi: 10.1136/esmoopen-2017-000219. eCollection 2017.

repository_institution: Harvard University - Digital Access to Scholarship at Harvard (DASH)

repository_institution: Red Federada de Repositorios Institucionales de Publicaciones Científicas - LA Referencia

repository_normalized: dnet

repositories_concat: PubMed Central;University of Melbourne - Minerva Access;dash.harvard.edu;dnet

ReferenceCitation: Ou SH. Crizotinib: a drug that crystallizes a unique molecular subset of non-small-cell lung cancer. Expert Rev Anticancer Ther. 2012 Feb;12(2):151-62. doi: 10.1586/era.11.186.

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location_facility: Taipei Veterans General Hospital, Chest Department

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location_facility: Hospital Universitario Marques de Valdecilla

location_facility: National Kyushu Cancer Center/Department of Thoracic Oncology

location_facility: Westdeutsches Tumorzentrum, Universitaetsklinikum Essen, Innere Klinik - Tumorforschung

location_facility: H Lee Moffitt Cancer Center & Research Institute

location_facility: Institut Catala D'Oncologia - Hospital Duran I Reynals

location_facility: SUNY Upstate Medical University, Regional Oncology Center

location_facility: Irmandade da Santa Casa de Misericordia de Porto Alegre

location_facility: Memorial Sloan-Kettering Cancer Center: Rockefeller Outpatient Pavilion

location_facility: Krankenhaus Grosshansdorf, Zentrum fuer Pneumologie und Thoraxchirurgie

location_facility: Klinikum der Universitaet zu Koeln, Klinik I fuer Innere Medizin

location_facility: Michael and Dianne Bienes Cancer Center, Holy Cross Hospital

location_facility: University General Hospital of Heraklion/ Department of Clinical Oncology

location_facility: Centro C.O.E.S., A.O. San Giovanni Battista Le Molinette

location_facility: University of California, Irvine-Medical Center

location_facility: Smilow Cancer Center at Yale New Haven, Oncology Pharmacy

location_facility: APHM - Hopital Nord / Service d'Oncologie Multidisciplinaire et Innovations Thérapeutiques

location_facility: Ingalls Memorial Hospital (Drug Shipment Only)

location_facility: Department of Clinical Oncology, Prince of Wales Hospital

location_facility: University of Hawaii - Cancer Research Center of Hawaii

location_facility: UT Southwestern Medical Center - Simmons Cancer Center Pharmacy

location_facility: Samsung Medical Center, Sungkyunkwan Univ School of Medicine

location_facility: DRUG SHIPMENT: University of Colorado Cancer Center

location_facility: University of Texas Southwestern Medical Center at Dallas

location_facility: National Hospital Organization Hokkaido Cancer Center

location_facility: Santa Monica-UCLA Medical Center & Orthopaedic Hospital Clinical Laboratory

location_facility: Seoul National University Hospital / Department of Internal Medicine

location_facility: The Harry and Jeanette Cancer Research Building

location_facility: Zhongshan Hospital Fudan University / Respiratory Department

location_facility: Hospital Universitari Germans Trias I Pujol

location_facility: University of Texas Southwestern University Hospital - Zale Lipshy

location_facility: Sarah Cannon Research Institute (Pharmacy)

location_facility: Hospital General Universitari Vall D´Hebron

location_facility: State Institution "National Cancer Research Center named after N.N. Blokhin' RAMS"

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location_facility: Oddzial Onkologii Klinicznej z Pododdzialem Dziennej Chemioterapii

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location_facility: Ship drug to: Investigational Drug Services

location_facility: MDOZS "Dr. Marko Markov", Otdelenie po onkoterapiya i paliativni grizhi

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location_facility: Orszagos Koranyi TBC es Pulmonologiai Intezet, VI. Bronchologia

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location_facility: University of California, Irvine-Pharmacy

location_facility: Hopital Notre-Dame du Centre Hospitalier de l'Universite de Montreal (CHUM)

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location_facility: Dartmouth Hitchcock Medical Center/Mary Hitchcock Memorial Hospital

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location_facility: Washington University School of Medicine

location_facility: Smilow Cancer Hospital at Yale New Haven

location_facility: Memorial Sloan - Kettering Cancer Center

location_facility: The Ohio State University James Cancer Hospital and Solove Research Institute

location_facility: General Hospital of Chest Diseases of Athens "Sotiria"

location_facility: MBAL Voennomeditsinska Academia, MMA HAT Sofia

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location_facility: Hospital Universitario Central de Asturias

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location_facility: Wojewodzki Szpital Specjalistyczny w Olsztynie, Zaklad Medycyny Nuklearnej

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location_facility: Indiana University Hospital Clarian Health

location_facility: Drug Shipping Address: Ronald Reagen University of California-Los Angeles

location_facility: Lisa Nakatsu, RPh (Drug Shipment Address)

title: Phase 2, Open-label Single Arm Study Of The Efficacy And Safety Of Pf-02341066 In Patients With Advanced Non-small Cell Lung Cancer (Nsclc) Harboring A Translocation Or Inversion Involving The Anaplastic Lymphoma Kinase (Alk) Gene Locus

design_allocation: Non-Randomized


type: EudraCT Number

title: Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects

summary: This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).

study_start_date_type: Actual

status: Terminated

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Prevention

enrollment_type: Actual

ReferenceType: derived

ReferenceCitation: Chasman DI, Hyde CL, Giulianini F, Danning RD, Wang EQ, Hickling T, Ridker PM, Loomis AK. Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1. Sci Rep. 2022 Mar 11;12(1):4266. doi: 10.1038/s41598-022-07997-5.

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evidence: oa repository (via pmcid lookup)

host_type: repository

license_normalized: no license

repository_normalized: PubMed Central

repositories_concat: PubMed Central

unpaywall_oa_status: gold

publisher_dissemination: Springer-Nature

ReferenceCitation: Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1.

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evidence: open (via free pdf)

version: acceptedVersion

unpaywall_oa_status: bronze

publisher_dissemination: Wolters Kluwer Health

ReferenceCitation: Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul-Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3.

oa_host_type: closed

repositories_concat: closed

publisher_dissemination: Elsevier

ReferenceCitation: Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.

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repository_institution: DANS - Data Archiving and Networked Services - NARCIS - National Academic Research and Collaborations Information System

evidence: oa repository (via OAI-PMH title and first author match)

repository_institution: University of Zaragoza Repository - Zaguan

repository_institution: The University of Glasgow - Enlighten: Publications

repository_institution: University of East Anglia - UEA Digital Repository

repositories_institution: Maastricht University - Research Publications

repositories_institution: The University of Glasgow - Enlighten: Publications

repositories_institution: University of East Anglia - UEA Digital Repository

repositories_institution: University of Zaragoza Repository - Zaguan

publisher_dissemination: Massachusetts Medical Society

lead_sponsor: Pfizer

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Germany
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Brazil
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Belgium
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Italy
United Kingdom
Sweden
Netherlands
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Spain
South Africa
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location_facility: FSBI "Research institute of complex problems of cardio-vascular diseases" of

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location_facility: Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna

location_facility: The Royal Liverpool and Broadgreen -University Hospitals NHS

location_facility: Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice

location_facility: Hospital Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: Clinical Research Advantage, Inc. / Cassidy Medical Group - Vista

location_facility: Grand Hopital de Charleroi, Site St-Joseph

location_facility: CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda

location_facility: County Clinical Emergency Hospital Sibiu

location_facility: Ocean Blue Medical Research Center, Inc.

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSA-CA) -

location_facility: Regional Budgetary Healthcare Institution "Cardiology Dispensary"

location_facility: Mae de Deus - Centro de Oncologia Radioterapica (COR)

location_facility: Austin Institute for Clinical Research, Inc.

location_facility: State Budgetary Educational Institution of Highest Professional Education

location_facility: MedStar Chesapeake CardioVascular Associates

location_facility: Investigational Product Shipment Address TO: Investigational Drug Services (IDS),

location_facility: INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie

location_facility: Wake Forest University Health Sciences Institutional Review Board

location_facility: Galilee Medical Center, Cardiology Department

location_facility: University of Alabama at Birmingham (Drug Shipment)

location_facility: Instituto de Cardiologia do Rio Grande do Sul / Fundacao Universitaria de Cardiologia

location_facility: Shuali Community Clinic, Clalit Health Services

location_facility: Hospital Universitario Marques De Valdecilla

location_facility: Municipal Autonomous Institution "City Clinical Hospital #14"

location_facility: Hallym University Kangdong Sacred Heart Hospital

location_facility: Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

location_facility: Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)

location_facility: Clinical Trials Unit,Bay of Plenty(BOP) Clinical School

location_facility: "Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of

location_facility: Gangnam Severance Hospital, Yonsei University Health System

location_facility: State Budgetary Healthcare Institution ¿Region Clinical Hospital #3¿

location_facility: A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS

location_facility: Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika

location_facility: Consultorio de Endocrinologia y Nutriologia

location_facility: Philadelphia Health Associates-Adult Medicine

location_facility: Hospital de Alta Complejidad "Pte. Juan Domingo Peron"

location_facility: Hospital Regional Universitario de Malaga

location_facility: EMED Centrum Uslug Medycznych Ewa Smialek

location_facility: Hudson Valley Cardiovascular Practice, PC

location_facility: State Autonomous Healthcare Institution of Yaroslavl Region

location_facility: Central Manchester University Hospitals NHS Foundation Trust

location_facility: Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room

location_facility: Department of Cardiology, Lyell McEwin Hospital

location_facility: Miguel Sosa-Padilla, MD-Private Practice

location_facility: Centre Hospitalier Universitaire (CHU) de Liege

location_facility: Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University"

location_facility: Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran"

location_facility: Fakultni poliklinika Vseobecne fakultni nemocnice v Praze

location_facility: Unicare Heart Institute & Research Center

location_facility: Clinical Research Institute of Northern Virginia

location_facility: Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin

location_facility: Hospital Mae de Deus-Associacao Educadora de Sao Carlos-AESC/IMV - Instituto de Medicina Vascular

location_facility: Limited Liability Company International Medical Centre SOGAZ

location_facility: Cardiology Research Associates of New Brunswick

location_facility: Hospital Universitario Virgen de la Victoria. CE San Jose Obrero

location_facility: ProMedica Northwest Ohio Cardiology Consultants

location_facility: SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko"

location_facility: Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic"

location_facility: Centro de Investigacion Clinica del Pacifico, S.A. de C.V.

location_facility: Municipal Budgetary Institution of Healthcare of Novosibirsk

location_facility: Instituto del Corazon de Bucaramanga S.A.

location_facility: McGlone Practice - Ballieston Health Centre

location_facility: Section of Nephrology and Hypertension, LSU Health Sciences Center-New Orleans

location_facility: CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A.

location_facility: Solutions Through Advanced Research, Inc.

location_facility: Centrum kardiovaskularni prevence 1. LF UK a TN

location_facility: FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across

location_facility: CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA

location_facility: BKS Research Kft., Albert Schweitzer Korhaz

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital"

location_facility: IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda

location_facility: Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Burger

location_facility: Dr. Mohan Babapulle Medicine Professional Cooperation

location_facility: Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS

location_facility: Saint Petersburg State Budgetary Institution of Healthcare

location_facility: State Institution of Healthcare "Regional Clinical Hospital"

location_facility: San Diego Family Care dba Linda Vista Health Center

location_facility: State Budgetary Healthcare Institution of Nizhegorodskaya Region

location_facility: Clinical Research Advantage, Inc./Michigan Avenue Internists

location_facility: Klinik und Poliklinik fuer Innere Medizin B-Kardiologie, Angiologie, Pulmologie, Internistische

location_facility: Chippenham and Johnston Willis Hospitals, Inc. dba CJW Medical Center

location_facility: Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre

location_facility: AOU Policlinico "Mater Domini" UOC di Medicina Interna

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky, I. interna klinika

location_facility: The Red Porto cabin, The James Cook University Hospital

location_facility: Women's & Family Care, LLC D.B.A. GTC Research

location_facility: Mercy Health Youngstown, LLC d/b/a St. Elizabeth Youngstown Hospital

location_facility: Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto

location_facility: Department of Neurology & Sagol Neuroscience Center

location_facility: Instituto de Cardiologia de Corrientes "Juana Fca. Cabral"

location_facility: Region Sjaelland Sygehus Nord, Koge Sygehus

location_facility: Research Institute of South Florida, Inc.

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego

location_facility: Azienda Ospedaliera Universitaria Santa Maria della Misericordia

location_facility: Seoul Metropolitan Government - Seoul National University Boramae Medical Center

location_facility: Dipartimento delle Patologie Emergenti, Unita di Medicina Interna e Dislipidemie Genetiche

location_facility: Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6"

location_facility: MHI "City Clinical Hospital 12"of the Healthcare Committee of

location_facility: CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche

location_facility: Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli

location_facility: State Budgetary Educational Institution of Higher Professional Education

location_facility: NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C.

location_facility: Centro Cientifico Asistencial Jose Luis Accini S.A.S.

location_facility: Cleveland Clinic - Taussig Cancer Institute

location_facility: Hospital Inovamed Cuernavaca (Emergencies)

location_facility: Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia

location_facility: MetroWest Medical Center - Pharmacy Department

location_facility: Cardiovascular Research Center of South Florida

location_facility: Southern Adelaide Diabetes and Endocrine Service

location_facility: Vseobecna kardiologicka ambulance s.r.o.

location_facility: The Catholic University Of Korea Seoul St.Marys Hospital

location_facility: CAP Disset De Setembre (Sant Cosme I Sant Damia)

location_facility: CAEP - Centro Avançado de Estudos e Pesquisas Ltda.

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika

location_facility: Vita Health & Medical Center, Inc./Concept Clinical Trials, LLC

location_facility: Synexus Merseyside Clinical Research Centre

location_facility: University hospitals Leuven - Neurology department

location_facility: Herlev Universitetshospital, Kardiologisk afdeling S

location_facility: State Budgetary Healthcare Institution (SBHI) N.N. Burdenko Regional Clinical Hospital of Penza

location_facility: Narodny Endokrinologicky A Diabetologicky Ustav N.O.

location_facility: Synexus Leipzig Clinical Research Centre

location_facility: Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka

location_facility: Ufuk University School of Medicine, Dr. Ridvan Ege Training & Research Hospital

location_facility: Instituto de Investigaciones Clinicas Mar del Plata

location_facility: Municipal Budgetary Institution of Healthcare Municipal Clinical Hospital #3 n.a. M.A. Podgorbunsky

location_facility: Peterborough and Stamford Hospitals NHS Foundation Trust

location_facility: Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin

location_facility: Novant Health Heart and Vascular Institute

location_facility: CSK MSW w Warszawie, Klinika Kardiologii Zachowawczej i Nadcisnienia Tetniczego

location_facility: Austin Health - Heidelberg Repatriation Hospital

location_facility: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

location_facility: Ospedale S. Maria della Misericordia -Dipartimento di Medicina, Medicina Interna,

location_facility: National Cheng Kung University (NCKU) Hospital

location_facility: Dr. Anil K. Gupta Medicine Professional Corporation

location_facility: LMC Diabetes & Endocrinology (Thornhill)

location_facility: Detweiler Family Medicine and Associates, PC

location_facility: State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2"

location_facility: Instituto de Diabetes Obesidad y Nutricion, S.C.

location_facility: Fundación Cardiovacular de Colombia - Instituto del Corazón de Floridablanca

location_facility: Kardiocentrum Nitra s.r.o., kardiologicka ambulancia

location_facility: Synexus Lancashire Clinical Research Centre

location_facility: FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2

location_facility: Southern Clinical Trials Shirley Ltd Don Beavan Medical Research Centre

location_facility: Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie,

location_facility: NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.

location_facility: CIPADI Centro Integral de Prevencion y Atencion en Diabetes

location_facility: "Tyumen Cardiology Center" Affiliate of the FSBSI "Scientific and Research Institution of Cardiology

location_facility: Synexus Midlands Clinical Research Centre

location_facility: Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital - New

location_facility: Scarborough Cardiology Research Associates Inc.

location_facility: PMG Research,Inc d/b/a PMG Research of Knoxville

location_facility: Ospedale Civile Regionale San Martino, Belluno

location_facility: SMO.MD GmbH - Zentrum fÃ¼r klinische Studien

location_facility: Hospital Provincial Dr. Jose Maria Cullen

location_facility: Rabin Medical Center, Beilinson Hospital

location_facility: Hospital Clinico Universitario Miguel Servet; Medicina Interna

location_facility: Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University

location_facility: Hospital Universitario Virgen De La Victoria

location_facility: Clinique des maladies lipidiques de Quebec

location_facility: State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital"

location_facility: Hospital Lomas de San Luis lntemacional (Emergencies)

location_facility: Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna

location_facility: Foothills Hospital/University of Calgary

location_facility: Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddzial Szybkiej Diagnostyki

location_facility: State Budgetary Institution "Ryazan Regional Clinical Hospital"

location_facility: Clinical Research Associates of Central PA

location_facility: Arcturus Healthcare, PLC, Troy Internal Medicine Research Division

location_facility: Wojskowy Instytut Medyczny, Klinika Kardiologii i Chorob Wewnetrznych, Centralny Szpital Kliniczny

location_facility: HealthEast St. Joseph's Hospital inpatient Pharmacy

location_facility: Cardiovascular Research of Northwest Indiana, LLC

location_facility: Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU

location_facility: Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital,

location_facility: AOUI di Verona - Ospedale Civile Maggiore Borgo Trento

location_facility: Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran

location_facility: MedStar Union Memorial Heart Specialists

location_facility: Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial

location_facility: Queen Elizabeth II Hospital, East and North Hertfordshire NHS Trust

location_facility: Holy Spirit Northside Private Hospital Limited

location_facility: University of Iowa-College of Public Health-Preventive Intervention Center

location_facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)

location_facility: Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni

location_facility: Centro de Diagnostico Cardiologico LTDA.

location_facility: Izmir Tepecik Egitim ve Arastirma Hastanesi

location_facility: Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD"

location_facility: Cardiovascular Research Foundation of Southern California

location_facility: Radboud University Nijmegen Medical Centre

location_facility: Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika

location_facility: Hospital Clinico Universitario de Santiago de Compostela

location_facility: Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis)

location_facility: NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska

location_facility: State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1

location_facility: SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF

location_facility: Gabinet Lekarski Malgorzata Saryusz-Wolska

location_facility: Black Hills Cardiovascular-Regional Health Research

location_facility: FGM-Clinica Paulista de Doencas Cardiovasculares

location_facility: South Florida Clinical Research Institute

location_facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

location_facility: IP + Dry ice deliveries Sugar Lakes Family Practice

location_facility: Midwest Heart & Vascular Specialists, LLC

location_facility: 1st Pavlov State Medical University of St. Petersburg

location_facility: Centrum Zdrowia Metabolicznego Pawel Bogdanski

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre

location_facility: Hospital Universitario Virgen de las Nieves (HUVN)

location_facility: Heart Institute, Hillel Yaffe Medical Center

location_facility: Hospital Universitario - Associacao Educadora Sao Carlos - AESC

location_facility: Dr. Kapil M. Bhagirath Medical Services Corporation

location_facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

location_facility: Roodepoort Medicross Clinical Research Centre

location_facility: Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet

location_facility: University Hospital Brussels- Diabeteskliniek

location_facility: Operadora de Hospitales Angeles S.A. de C.V. (Emergencies)

location_facility: John Muir Physician Network Clinical Research Center

location_facility: NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych

location_facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach

location_facility: Centre integre de sante et de services sociaux de Lanaudiere (CISSSL)

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego

location_facility: Hospital Mae de Deus - Instituto do Cancer

location_facility: Narodny ustav srdcovych a cievnych chorob, a.s.

location_facility: Federal State Budgetary Institution "Federal Almazov Medical Research Centre" of

location_facility: Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice

location_facility: St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare

location_facility: ILAIM Instituto Latinoamericano de Investigaciones Medicas

location_facility: Seoul National University Bundang Hospital

location_facility: Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia

location_facility: Centro De Investigaciones Clinicas Del Litoral S.R.L.

location_facility: Unidad de Investigacion Clinica y Atencion Medica Hepa S.C.

location_facility: Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila

location_facility: UN Bratislava Nemocnica Sv.Cyrila a Metoda, kardiologicka ambulancia 1

location_facility: Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek

location_facility: Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin"

location_facility: Institute of Cardiovascular Diseases Timisoara

location_facility: Regionshospitalet Silkeborg, Hjerte Projektkontor

location_facility: Centro de Pesquisas Medicas Basica e Clinica LTDA

location_facility: North Ohio Heart Center (Administrative Only)

location_facility: Northeast Clinical Research of San Antonio, LLC (NECRSA, LLC)

location_facility: London Road Diagnostic Clinic and Medical Centre

location_facility: State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary"

location_facility: Hopital Cardiovasculaire Et Pneumologique Louis Pradel

location_facility: Hospital Del Pacifico,Centro De Investigacion Clinica Del Pacifico Cicpa,Torre Medica Del Pacifico

location_facility: Berlin Research Centre-Synexus Clinical Research GmbH

location_facility: Clinresco Centres (Pty) Ltd-Central Professional Suits

location_facility: Centro de Investigaciones Clinicas "Instituto del Corazon"

location_facility: Pharmacology and Clinical Research S.A. de C.V.

location_facility: Cardio D&R spol.s.r.o., kardiologicka ambulancia

location_facility: Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda

location_facility: Institution Centrul Medical Sf. Stefan SRL, Diabet Nutritie si Boli Metabolice

location_facility: Lillehei Clinical Research Unit, University of Minnesota

location_facility: State Budget Institution of Healthcare (SBIH) of Moscow "City Clinical Hospital #81

location_facility: State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8"

location_facility: SPZOZ Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego

location_facility: Canadian Centre for Research on Diabetes

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala

location_facility: Dip Medicina Interna e Specialita Mediche, Policlinico Umberto I

location_facility: Caprock Cardiac Center Research Institute Inc.

location_facility: Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic"

location_facility: Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA.

location_facility: John V. Bernard, MD dba Wellness and Research Center

location_facility: Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A.

location_facility: DIAMEL, s.r.o., Diabetologicka ambulancia

location_facility: Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, Poradnie Specjalistyczne,

location_facility: Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly

location_facility: Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,

location_facility: Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA

location_facility: Hospital Universitario La Paz; Unidad Metabolico-Vascular

location_facility: Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski

location_facility: Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital

location_facility: Metabolicke Centrum MUDr. Katariny Raslovej, S.R.O.

location_facility: Instituto de Investigaciones Clinicas Zarate

location_facility: North Shore Hospital- Inpatient Pharmacy

location_facility: Glacier View Research Institute, Cardiology

location_facility: Stroke Prevention & Atherosclerosis Research Centre (SPARC)

location_facility: Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez

location_facility: Universitaets Herzzentrum Freiburg Bad Krozingen

location_facility: Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut

location_facility: Premier Health Specialists, Inc. (dba Dayton Heart Center)

location_facility: Instituto Biomedico De Investigacion A.C.

location_facility: Landa Specjalistyczne Gabinety Lekarskie

location_facility: Advanced Clinical Research of Miami (ACROM) International

location_facility: Rutgers Biomedical and Health Sciences-Robert Wood Johnson Medical School

location_facility: Bogna Gabrylewicz Andrzej Ochala Unimed s.c.

location_facility: Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas

location_facility: Morton Plant Mease Health Care, Inc. Cardiovascular Research

location_facility: Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM

location_facility: Hospital Universitario San Juan de Alicante

location_facility: Philippe R. Beaudry Medicine Professional Corporation

location_facility: Univerzitna nemocnica Bmtislava, Nemocnica Stare Mesto

location_facility: Istanbul Universitesi Istanbul Tip Fakultesi

location_facility: Instytut Kardiologii, Ii Klinika Choroby WieCowej

location_facility: Ribo Research, LLC dba Peninsula Research

location_facility: Austin Institute for Clinical Research,Inc.

location_facility: Clinica Privada de Especialidades Medicas

location_facility: IKF Institut fuer klinische Forschung Frankfurt

location_facility: State Regional Budgetary Healthcare Institution

location_facility: Doylestown Health Cardiology, a division of Doylestown Health Physicians

location_facility: Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, President's

location_facility: Zentrum Klinische Studien Neuwied (ZKSN)

location_facility: Hospitaux Universitaires de Geneve (HUG)

location_facility: Synexus Scotland Clinical Research Centre

location_facility: Istanbul Universitesi Kardiyoloji Enstitusu

location_facility: Fakultni nemocnice Hradec Kralove, III. Interni gerontometabolicka klinika

location_facility: Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie

location_facility: Optimamed Specjalistyczne Gabinety Lekarskie

location_facility: Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna

location_facility: Allina Health System, dba Abbott Northwestern Hospital

location_facility: Northeast Iowa Medical Education Foundation

location_facility: Consultorio Dr. Leocadio Gerardo Munoz Beltran

location_facility: State Autonomous Healthcare Institution "Republic Clinical Hospital"

location_facility: Centro Especializado en Diabetes Obesidad y Prevencion de Enfermedades Cardiovasculares, SC.

location_facility: Sparrow Thoracic & Cardiovascular Institute

location_facility: St. Mary's Medical Center dba Essentia Health St. Mary's Medical Center

location_facility: Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.

location_facility: Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV

location_facility: Pharmacy - Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: Cardiology Consultants of Orange County Medical Group, Inc.

location_facility: Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III

location_facility: Jehangir Clinical Development Centre Pvt. Ltd.

location_facility: Karlkliniken, Skanes Universitetssjukhus i Malmo

location_facility: Oklahoma Heart Hospital Research Foundation

location_facility: Clinical Research Advantage, Inc. / Family Medicine Associates

location_facility: Clinphenomics Gmbh & Co Kg, Studienzentrum

location_facility: Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni

location_facility: "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """

location_facility: Specjalistyczna Praktyka Lekarska Piotr Kubalski

location_facility: New Orleans Center for Clinical Research

location_facility: Pfuetzner Science & Health Institute-Gmbh

location_facility: Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders

location_facility: Tyumen Cardiology Research Center-branch of the Tomsk NRMC

location_facility: Hospital Universitario Sant Joan de Reus

location_facility: Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U

location_facility: Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga

location_facility: Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi

location_facility: State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency

location_facility: Westside Medical Associates of Los Angeles

location_facility: Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15"

location_facility: County Clinical Emergency Hospital Oradea

location_facility: Universitatsklinikum des Saarlandes Klinik fur Innere Medizin III

location_facility: Metabol KLINIK s.r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy

location_facility: Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi

location_facility: Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First

location_facility: Hospital General Universitario Morales Meseguer

location_facility: SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit

location_facility: Apex Heart Institute (A Unit of TCVS Pvt. Ltd)

location_facility: Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat Nutritie si Boli Metabolice

location_facility: Cardiovascular Clinical Research Institute

location_facility: The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde

location_facility: Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol

location_facility: Albany Medical College, Division of Community Endocrinology

location_facility: S.C. Centrul Medical "Sanatatea Ta" S.R.L.

location_facility: Gottsegen Gyorgy Orszagos Kardiologiai Intezet

location_facility: Vizel Cardiac Research - Saul Vizel Professional Medicine Corporation

location_facility: MUDr. Kanderkova s.r.o., Diabetologicka ambulancia

location_facility: Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi

location_facility: Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO

location_facility: West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc.

location_facility: Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology

location_facility: Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust

location_facility: LeBauer Cardiovascular Research Foundation

location_facility: Synexus North East Clinical Research Centre - Hexham General Hospital

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o.

location_facility: Saint Luke's Lipid and Diabetes Research Center

location_facility: Dr. Richard Bon Inc. & Dr. Adam Yeung Inc.

location_facility: Synexus Polska Sp. z o.o Oddzial w Poznaniu

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: California Medical Research Associates Inc.

location_facility: Missouri Cardiovascular Specialists, LLP

location_facility: Centre Hospitalier de Cannes- Service de Cardiologie

location_facility: Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital"

location_facility: Women's & Family Care D.B.A. GTC Research

location_facility: Evanston Premier Healthcare Research, LLC

location_facility: FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation based on Clinical

location_facility: St. Joseph Mercy Health System (Drug shipment Only)

location_facility: University Hospital Brussels - Centrum voor hart- en vaatziekten

intervention_type: Drug

lead_sponsor_type: industriel

status_simplified: Unknown