title: A Clinical Study to Investigate Interferon Gamma (IFNɣ) Signature in Patients Post HSCT and in Patients With Impaired HSC Proliferation Pre-transplant

summary: Clinical study designed to collect blood for research purposes in patients after hematopoietic stem cell transplantation (HSCT) or in patients with a medical condition where the blood cells production is impaired. The blood samples will be used to study the role of Interferon gamma (IFNɣ) in graft failure or impairment of hematopoietic stem cell proliferation. The IFNɣ signature will be assessed by measuring primarily IFNɣ and C-X-C Motif Chemokine Ligand 9 (CXCL9).

lead_sponsor: Swedish Orphan Biovitrum

location_country:
United Kingdom
Italy
Netherlands
France
Belgium
Germany

location_facility: Azienda Ospedaliera San Giuseppe Moscati

location_facility: Centre Hosptitalier Universitaire d'Angers

location_facility: Imperial College Healthcare NHS Trust NHS Trust

location_facility: Ospedale Pediatrico Bambino Gesù - Roma - Gianicolo

location_facility: Algemeen Ziekenhuis Delta - Campus Rumbeke

location_facility: Centre Hospitalier Universitaire Estaing

location_facility: Centre Hospitalier Universitaire Grenoble Alpes

location_facility: Cardiff and Vale University Health Board

location_facility: Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz


title: Multicenter International Observational Study to Build and Validate Multidimensional Risk Score in the Clinical Setting of Kidney Allograft Biopsies to Predict Long-term Allograft Survival

acronym: iBOX

summary:
To further develop personalized medicine in kidney transplantation and improve transplant patient outcomes, attention has been given to define early surrogate endpoints that might aid therapeutic interventions, clinical trials and clinical decision-making.

Despite a clear pressing need, no population-scale prognostication system exists that will combine traditional factors and biomarker candidates to represent the complete spectrum of risk predicting parameters. To adequately predict transplant patients' individual risks of allograft loss, this would require a complex integration of data, including: donor data, recipient characteristics, transplant characteristics, allograft precision phenotypes, ethnicity, immunosuppressive regimen monitoring, allograft infections, acute kidney injuries, and recipient immune profiles.

This project aims:

To develop a generalizable, transportable, mechanistically and data driven composite surrogate end point in kidney transplantation;
To validate several risk scores to predict kidney allograft survival and response to treatment of individual patients;

Eventually, it will provide an easily accessible tool to calculate individual patients' risk profiles after kidney transplantation, by using datasets from prospective cohorts and post hoc analysis of randomized control trial datasets.

study_start_date_type: Actual

status: Completed

study_completion_date_type: Actual

study_type: Observational

time_perspective: Prospective

enrollment_type: Actual

ReferenceType: derived

ReferenceCitation: Aubert O, Divard G, Pascual J, Oppenheimer F, Sommerer C, Citterio F, Tedesco H, Chadban S, Henry M, Vincenti F, Srinivas T, Watarai Y, Legendre C, Bernhardt P, Loupy A. Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study. BMJ Open. 2021 Oct 7;11(10):e052138. doi: 10.1136/bmjopen-2021-052138.

ReferenceCitation: Loupy A, Aubert O, Orandi BJ, Naesens M, Bouatou Y, Raynaud M, Divard G, Jackson AM, Viglietti D, Giral M, Kamar N, Thaunat O, Morelon E, Delahousse M, Kuypers D, Hertig A, Rondeau E, Bailly E, Eskandary F, Böhmig G, Gupta G, Glotz D, Legendre C, Montgomery RA, Stegall MD, Empana JP, Jouven X, Segev DL, Lefaucheur C. Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study. BMJ. 2019 Sep 17;366:l4923. doi: 10.1136/bmj.l4923.

ipd_sharing: No

lead_sponsor: Paris Translational Research Center for Organ Transplantation

location_country:
United States
France
Belgium

location_facility: Department of Nephrology and Renal Transplantation, University Hospitals Leuven

location_facility: William J. von Liebig Center for Transplantation and Clinical Regeneration

location_facility: Department of Surgery, Johns Hopkins University School of Medicine

location_facility: Centre Hospitalier Universitaire de Nantes

location_facility: Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France ;

location_facility: Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon

location_facility: Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France;

location_facility: Department of Nephrology and Organ Transplantation, CHU Rangueil

location_facility: Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Foch, Suresnes, France

location_facility: Virginia Commonwealth University School of Medicine

intervention_type: Other

lead_sponsor_type: industriel

status_simplified: Completed


title: Life Experience of People Aged 60 and Over Living With HIV: Quantitative Sociological Study

acronym: PVVIH

summary: The purpose of this study is to Assess the impact of HIV on the life course of patients aged 60 and over.

lead_sponsor: Centre Hospitalier René Dubos

location_facility: Hospital Beaujon, Clichy / Médecine Interne

location_facility: Hospital Delafontaine, Saint-Denis / Maladie infectieuse

location_facility: Hôpital Bichat Claude-Bernard - Service de Maladies Infectieuses et Tropicales

location_facility: Hôpital Bichat Claude-Bernard -COREVIH Ile de France Nord

lead_sponsor_type: academique


title: mTor-inhibitor (EVERolimus) Based Immunosuppressive Strategies for CNI Minimisation in OLD for Old Renal Transplantation

acronym: EVEROLD

summary: This study is designed to evaluate efficacity and safety of everolimus or (cyclosporine then everolimus) vs. cyclosporine as immunosuppressive treatment in renal transplantation for elderly (>60 years old) recipients receiving graft from elderly donor(>60 years old).

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

lead_sponsor: University Hospital, Brest

location_facility:
CHU Tours
AP-HP Hopital Necker
CHU Clermont Ferrand
CHU Montpellier
CHU Lille
CHU Poitiers
CHU Rennes
CHU Rouen
Hopitaux Universitaires de Strasbourg
CHRU de BREST
CHU Limoges
CHU Nice
CHU Cote de Nacre
CHU Rangueil - Toulouse
CHU Reims
CHU Amiens
CHU Dijon
CHU Pellegrin - Bordeaux

intervention_type: Drug


type: Other Grant/Funding Number

title: Impact of an Intensive Therapeutic Education on Occurrence of Clinical Events in Patients With Acute Heart Failure: EduStra-HF Study

acronym: EduStra-HF

summary:
The EduStra-HF study will examine the impact of an intensive therapeutic education on patients discharged from hospital after an episode of acute heart failure (HF).

Patients will be randomized into two groups: one will receive "usual care" monitoring and one will receive a specific educational monitoring programme for 1 year.

All patients will meet with a specialized therapeutic education nurse before discharge.

The effect of the intensive education on HF rehospitalization and quality of life will be examined.

status: Recruiting

study_completion_date_type: Anticipated

primary_purpose: Supportive Care

enrollment_type: Anticipated

ipd_sharing: Undecided

ipd_sharing_description: Sharing Individual Participant Data requires a specific authorization from the French Board CNIL (Commission Nationale de l'Informatique et des Libertés) which chooses whether to allow the research team to share patient data. A specific request is needed and will be sent to that authority.

lead_sponsor: Resicard

location_facility:
Hôpital AP-HP Pitié-Salpêtrière
Centre Cardiologique du Nord
Hopital AP-HP Saint-Antoine
Centre Hospitalier André Mignot
Clinique Ambroise Paré
Clinique du Mont Louis
Institut Mutualiste Montsouris

intervention_type: Behavioral

status_simplified: Ongoing


type: EudraCT Number

type: Other Identifier

title: An International Clinical Program for the Diagnosis and Treatment of Children, Adolescents and Young Adults With Ependymoma

acronym: SIOP-EP-II

summary:
The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving and harmonising the staging and the standard of care of this patient population and to improve the investigators understanding of the underlying biology thereby informing future treatment.

The program will evaluate new strategies for diagnosis (centralized reviews of pathology and imaging) and new therapeutic strategies in order to develop treatment recommendations.

Patients will be stratified into different treatment subgroups according to their age, the tumour location and the outcome of the initial surgery. Each subgroup will be studied in a specific randomised study to evaluate the proposed therapeutic strategies.

Stratum 1:

The aim of the stratum 1 is to evaluate the clinical impact of 16-week chemotherapy regimen with VEC-CDDP following surgical resection and conformal radiotherapy in terms of progression free survival in patients who are > 12 months and < 22 years at diagnosis, with completely removed intra cranial Ependymoma.

Stratum 2:

This stratum is designed as a phase II trial for patients who are > 12 months and < 22 years at diagnosis, with residual disease to investigate the possible activity of HD-MTX by giving to all patients the benefit of VEC chemotherapy whilst randomising half of patients to receive additional HD-MTX.

Patients will receive conformal radiotherapy (cRT). For patients who remain with a residual inoperable disease after induction chemotherapy and cRT, an 8 Gy boost of radiotherapy to the residual tumour will be delivered immediately after the end of the cRT.

Stratum 3 This stratum is designed as a phase II trial to evaluate the benefit of postoperative dose intense chemotherapy administered alone or in combination with valproate in children <12 months of age or those not eligible to receive radiotherapy .

ReferenceCitation: Leblond P, Massimino M, English M, Ritzmann TA, Gandola L, Calaminus G, Thomas S, Pérol D, Gautier J, Grundy RG, Frappaz D. Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol. Front Neurol. 2022 Jun 2;13:887544. doi: 10.3389/fneur.2022.887544. eCollection 2022.

lead_sponsor: Centre Leon Berard

location_country:
Denmark
Slovenia
Ireland
Austria
Italy
Netherlands
Spain
United Kingdom
Switzerland
Sweden
France
Belgium
Norway
Germany
Czechia

location_facility: University Medical Center Hamburg-Eppendorf

location_facility: Medical University of Graz-Department of Pediatrics and Adolescent Medicine

location_facility: CHRU STRASBOURG - Hôpital de Hautepierre

location_facility: Department of Paediatric, Haukeland University Hospital

location_facility: Hospitales Universitarios Virgen Macarena y Virgen del Rocío Avda

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: CHU de Bordeaux-Hôpital des enfants Pellegrin

location_facility: Princess Maxima Center for pediatric oncology

location_facility: CHRU MONTPELLIER - Hôpital Arnaud de Villeneuve

intervention_type: Radiation


ipd_sharing: Yes

status: Active, not recruiting

title: RATIONALE-301: A Randomized, Open-label, Multicenter Phase 3 Study to Compare the Efficacy and Safety of BGB-A317 Versus Sorafenib as First-Line Treatment in Patients With Unresectable Hepatocellular Carcinoma

lead_sponsor: BeiGene

type: Registry Identifier

source: euctr

ReferenceType: result

ReferenceCitation: Qin S, Finn RS, Kudo M, Meyer T, Vogel A, Ducreux M, Macarulla TM, Tomasello G, Boisserie F, Hou J, Li X, Song J, Zhu AX. RATIONALE 301 study: tislelizumab versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma. Future Oncol. 2019 Jun;15(16):1811-1822. doi: 10.2217/fon-2019-0097. Epub 2019 Apr 10.

location_country:
Poland
Taiwan
Spain
Italy
United Kingdom
United States
France
China
Japan
Germany
Czechia

location_facility: CHU Amiens-Hopital Nord - Hépato-Gastroentérologie

location_facility: The First Affiliated Hospital of Bengbu Medical College

location_facility: National Center for Global Health and Medicine

location_facility: PO G.Rodolico, AOU Policlinico-Vittorio Emanuele di Catania

location_facility: The Affiliated Hospital Of Qingdao University

location_facility: Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital

location_facility: Bichat-Beaujon Service Inter Hospitalier De Cancerologie

location_facility: Massachusetts General Hospital Cancer Center

location_facility: IRCCS Saverio De Bellis, AO Gastroenterologia

location_facility: CHU Cote De Nacre - Hepato-Gastro-Enterologie Et N

location_facility: University Hospital, Kyoto Prefectural Univ of Medicine

location_facility: Hospital Universitario Madrid Sanchinarro Centro integral Oncologico Clara Campal (CIOCC)

location_facility: Harbin Medical University Cancer Hospital

location_facility: The Second Affiliated Hospital of Nanchang University

location_facility: The First Affiliated Hospital of Soochow University

location_facility: Ehime Prefectural Central Hospital - Gastroenterology

location_facility: Hokkaido University Hospital - Gastroenterology

location_facility: Ist. Clinici Scientifici Maugeri - Unità Operativa di Oncologia

location_facility: Sun Yat-sen Memorial Hospital , Sun Yat-sen University

location_facility: Fujian Medical University Union Hospital

location_facility: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

location_facility: Beijing YouAn Hospital, Capital Medical University

location_facility: Wojewodzki Szpital Specjalistyczny im. Gromkowskiego we Wroclawiu

location_facility: Ochsner Medical Center (OMC) - New Orleans ACCRU Network Sit

location_facility: Tianjin Medical University Cancer Institute and Hospital

location_facility: University of California - Hematology and Oncology

location_facility: Sir Run Run Shaw Hospital, Zhejiang University

location_facility: Hôpital Privé des Côtes d'Armor - Service oncologie

location_facility: The First Affiliated Hospital of Chongqing Medical University

location_facility: The First Affiliated Hospital Of XI'AN Jiaotong University

location_facility: China Medical University Hospital - Transplantology - Taichung

location_facility: The First Affiliated Hospital of Guangxi Medical University

location_facility: The First Affiliated Hospital Of Anhui Medical University

location_facility: PO di Cremona, ASST di Cremona - Oncologia - Cremona - Radiology

location_facility: Policlinico S.Orsola Malpighi, AOU di Bologna - SSD Malattie

location_facility: The First Affiliated Hospital, Sun Yat-sen University

location_facility: White Plains Hospital Center for Cancer Care - Oncology

location_facility: Regina Elena, Istituto Nazionale dei Tumori, IFO, IRCCS

location_facility: Cancer Hopital Chinese Academy of Medical Sciences

location_facility: Anhui Medical University - The Second Hospital

location_facility: Centrum Onkologii Instytut im. M. Sklodowskiej-Curie

location_facility: Vanderbilt University Medical Center (VUMC)

location_facility: Cancer Treatment Centers of America - Oncology

location_facility: Tri-Service General Hospital - Neihu Branch

location_facility: Hahnemann University Hospital - Gastroenterology Hepatology

location_facility: Shanghai Cancer Hospital of Fudan University

location_facility: Nihon University Itabashi Hospital - Gastroenterological surgery

location_facility: Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Gastroenterology

location_facility: Precision Cancer Research / Dayton Physicians Network

location_facility: Hopital Paul Brousse- Aphp Hopitaux Universitairees Paris Su

location_facility: King's College Hospital NHS Foundation Trust

location_facility: Hospital Universitari i Politecnic La Fe

location_facility: Kinki University Hospital, Faculty of Medicine - Hematology & Clinical Oncology

location_facility: The First Affiliated Hospital of Zhejiang University

location_facility: Kaohsiung Medical University - Chung-Ho Memorial Hospital

location_facility: Clinical Research Center Sp. z o.o., Medic-R Sp. K.

location_facility: Queen Elizabeth Hospital - Clinical Reasearch

location_facility: The Christie NHS Foundation Trust - Oak Road Treatment Centre

summary: This is a Phase 3, randomized, open-label, multicenter, global study designed to compare the efficacy and safety of tislelizumab versus sorafenib as a first-line systemic treatment in participants with unresectable hepatocellular carcinoma. This study also includes a substudy investigating the safety, tolerability, PK, and preliminary efficacy in HCC in Japanese participants. In Japan, preliminary safety and tolerability will be evaluated (Safety Run-In Substudy) before Japanese participants are recruited in this Phase 3 study.


title: AURORA: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Cenicriviroc for the Treatment of Liver Fibrosis in Adult Subjects With Nonalcoholic Steatohepatitis

acronym: AURORA

summary: The AURORA study will be conducted to confirm the efficacy and safety of cenicriviroc (CVC) for the treatment of liver fibrosis in adult participants with NASH.

status: Terminated

lead_sponsor: Tobira Therapeutics, Inc.

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Romania
Poland
Hong Kong
Portugal
Austria
Australia
Russian Federation
Puerto Rico
Israel
Mexico
Norway
Singapore
Brazil
Canada
Switzerland
Hungary
Germany
Taiwan
Greece
Latvia
New Zealand
France
Chile

location_facility: Innovative Medical Research of South Florida, Inc.

location_facility: Kings College Hospital NHS Foundation Trust

location_facility: Southern Star Research Institute, LLC SAGACT PLLC.

location_facility: Rambam Health Care Campus - Rambam Medical Center

location_facility: Washington University School of Medicine

location_facility: Centre Hospitalier Universitaire de Rouen CHU de Rouen Hopital Charles-Nicolle

location_facility: Texas Digestive Disease Consultants - Fort Worth

location_facility: Fondazione Policlinico Universitario Agostino Gemelli

location_facility: Sklifosovsky Scientific Research Institution of Emergency Care

location_facility: Chang Gung Medical Foundation-LinKou Branch

location_facility: Synexus Polska Sp z o o Oddzial w Poznaniu

location_facility: Southern California Permanente Medical Group

location_facility: Centre Hospitalier Universitaire de Nice Hôpital l'Archet

location_facility: Faculdade de Medicina de São José do Rio Preto Hospital de Base

location_facility: Institutul Regional de Gastroenterologie si Hepatologie Prof. Dr. O Fodor

location_facility: Advanced Clinical Research - Center for Digestive Health

location_facility: Digestive Health Specialists of the Southeast

location_facility: Gastroenterology Associates of Northern Virginia

location_facility: Centrum Badan Klinicznych Piotr Napora Lekarze Spólka Partnerska

location_facility: Synexus Lancashire Clinical Research Centre

location_facility: Synexus Polska Sp. z o.o. Oddział w Warszawie

location_facility: Stanford School of Medicine, Center for Clinical Sciences Research

location_facility: Hull and East Yorkshire Hospitals NHS Trust

location_facility: Philipps-Universität und Universitätsklinikum Gießen und Marburg GmbH

location_facility: Centre Hospitalier Universitaire Grenoble

location_facility: Hapital Sud Service d'Hepato- Gastroentarologie

location_facility: Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

location_facility: University of San Francisco, Fresno Medical Education Program

location_facility: Consorci Hospital General Universitari de València

location_facility: Universitätsmedizin der Johannes Gutenberg Universität Mainz

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: Gastroenterology Consultants of Southwest Virginia Research

location_facility: Baylor Scott & White All Saints Medical Center - Ft. Worth

location_facility: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

location_facility: Synexus Polska Sp. Z o.o. Oddzial w Czestochowie

location_facility: Gastroenterology Associates of Central Georgia

location_facility: Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

location_facility: Barts Health NHS Trust The Royal London Hospital

location_facility: University Hospital of South Manchester NHS Foundation Trust

location_facility: National Diabetes and Obesity Research Institute

location_facility: Centre Hospitalier Regional et Universitaire de Besancon - L'Hopital Jean Minjoz

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku

location_facility: Universitatsklinik far Innere Medizin II

location_facility: Synexus Clinical Research GmbH, Prüfzentrum Berlin

location_facility: Diabetes & Glandular Disease Clinic, P.A. (DGD)

location_facility: Luton and Dunstable Hospital NHS Foundation Trust

location_facility: ASST Grande Ospedale Metropolitano Niguarda

location_facility: Objective GI D/B/A North Alabama GI Research Center

location_facility: Moscow Regional Research and Clinical Institute M.F. Vladimirsky

location_facility: GI Specialists of Georgia - Marietta Office

location_facility: Ruane Medical and Liver Health Institute

location_facility: Eastern Pennsylvania Gastroenterology and Liver Specialist

location_facility: Marshall University Joan C. Edwards School of Medicine

location_facility: Consultorio Médico Dr. Alma Laura Ladron de Guevara

location_facility: Azienda Ospedaliera Universitaria Careggi SOD Medicina Interna ed Epatologia

location_facility: Bruce W. Carter Department of Veterans Affairs Medical Center

location_facility: Hospital Clínico Universitario Virgen de la Victoria

location_facility: Indianapolis Gastroenterology Research Foundation

location_facility: Hospital Universitário Clementino Fraga Filho

location_facility: CHU De Bordeaux - Hôpital Haût-Lévèque CMC Magellan Unita de Recherche Clinique

location_facility: Synexus Clinical Research GmbH, Prüfzentrum Frankfurt

location_facility: Hospital das Clínicas da Universidade Federal de Minas Gerais

location_facility: Gastroenterology Associates of Pensacola

location_facility: Gastroenterology Associates - Crystal River

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni ul.

location_facility: Digestive Healthcare of Georgia - Atlanta

location_facility: Chelsea and Westminster Hospital NHS Foundation Trust

location_facility: Center Hospitalier Universitaire d'Angers

location_facility: Hadassah Medical Center, Institute of Gastroenterology and Liver Diseases

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: Centre Hospitalier Universitaire de Rennes- Hôpital Pontchaillou

location_facility: Nottingham Digestive Diseases Biomedical Research Unit

location_facility: The Ohio University - Gastroenterology, Hepatology

location_facility: UT-Memphis, Methodist University Hospital

location_facility: Centre Hospitalier Universitaire Estaing

location_facility: Pauls Stradins Clinical University Hospital

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: University Hospitals Birmingham NHS Foundation Trust

location_facility: William Osler Health Centre, Brampton Memorial Hospital Campus

location_facility: Consultorio Dra. Maria Sarai Gonzalez Huezo

location_facility: Hospital Universitario Nuestra Senora de Valme

location_facility: University of Iowa Hospitals and Clinics

location_facility: Synexus Polska Sp. z o.o. Oddział w Łodzi

location_facility: Centro de Investigaciones Clínicas Viña del Mar

location_facility: Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft

location_facility: NYU Langone Health - Perlmutter Cancer Center

location_facility: Gastroenterology Associates of Fairfield County

location_facility: Medical Professional Clinical Research Center, INC

location_facility: Investigational Drug Service, The University of North Carolina at Chapel Hill

location_facility: Michael E. DeBakey VA Medical Center (MEDVAMC)

location_facility: Southern California Kaiser Permanente, Los Angeles Medical Center

location_facility: Digestive Health Associates of Texas-Rockwall

location_facility: University of Texas Southwestern Medical Center

location_facility: SYNEXUS Magyarország Kft. - Budapest DRS

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Wojewódzki Specjalistyczny Szpital im. dr Wl. Bieganskiego w Lodzi

status_simplified: Unknown


intervention_type: Biological

title: A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Adjuvant Chemotherapy With or Without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative Intent (KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

lead_sponsor: Merck Sharp & Dohme LLC

location_country:
Spain
Italy
United Kingdom
Ukraine
United States
Belgium
Japan
Czechia
Poland
Austria
Russian Federation
Argentina
Israel
Turkey
Mexico
Norway
Sweden
Canada
China
Germany
Denmark
Taiwan
Greece
Finland
Korea, Republic of
France
Chile
Colombia

location_facility: Hokkaido University Hospital ( Site 4194)

location_facility: Universitaetsklinikum Tuebingen ( Site 2113)

location_facility: Institut Universitaire du Cancer Toulouse - Oncopole ( Site 2065)

location_facility: Universitätsklinikum Schleswig-Holstein ( Site 2101)

location_facility: Hospital Britanico de Buenos Aires ( Site 1002)

location_facility: SO Grigoriev Institute for Medical Radiology and Oncology of NAMS of Ukraine ( Site 2363)

location_facility: Geniko Panepistimako Nosokomeio ARETEIO ( Site 2423)

location_facility: The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C

location_facility: Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2641)

location_facility: HonorHealth Research Institute - Biltmore ( Site 3043)

location_facility: Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 2645)

location_facility: Chernihiv Medical Center of Modern Oncology ( Site 2368)

location_facility: Niigata Cancer Center Hospital ( Site 4185)

location_facility: Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2487)

location_facility: Royal Marsden Hospital Sutton-Surrey ( Site 2241)

location_facility: The Christie Hospital NHS Foundation Trust ( Site 2243)

location_facility: Soerlandet sykehus HF Kristiansand ( Site 2152)

location_facility: Shizuoka Cancer Center Hospital and Research Institute ( Site 4192)

location_facility: Centre Hospitalier de l Universite de Montreal - CHUM ( Site 3006)

location_facility: Gunma Prefectural Cancer Center ( Site 4183)

location_facility: Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 2394)

location_facility: Instituto Cancerologico de Narino Ltda ( Site 1092)

location_facility: Fakultni nemocnice Kralovske Vinohrady ( Site 2393)

location_facility: Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2636)

location_facility: Centro Investigación del Cáncer James Lind ( Site 1061)

location_facility: Christus Muguerza Clinica Vidriera ( Site 1125)

location_facility: Medizinische Hochschule Hannover-Department of Obstetrics and Gynecology ( Site 2109)

location_facility: Universitair Ziekenhuis Gent ( Site 2037)

location_facility: Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 2350)

location_facility: IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 1006)

location_facility: Cukurova Uni. Tip Fakultesi ( Site 2353)

location_facility: Instituto Nacional de Cancerología E.S.E ( Site 1094)

location_facility: Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 2134)

location_facility: Women s Hospital School of Medicine Zhejiang University ( Site 4032)

location_facility: Medipol Universite Hastanesi ( Site 2352)

location_facility: SLK-Kliniken Heilbronn GmbH ( Site 2116)

location_facility: Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3

location_facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2127)

location_facility: General Hospital of Patras. St Andrews ( Site 2421)

location_facility: Istituto di Candiolo - IRCCS ( Site 2125)

location_facility: Yunnan Province Cancer Hospital-Gynecology Department ( Site 4055)

location_facility: Krasnoyarsk Regional Clinical oncology dispensary ( Site 2643)

location_facility: Royal Marsden NHS Foundation Trust ( Site 2248)

location_facility: Ege University Medical Faculty ( Site 2351)

location_facility: University of South Alabama, Mitchell Cancer Institute ( Site 3058)

location_facility: Osaka International Cancer Institute ( Site 4188)

location_facility: Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063)

location_facility: Obstetrics and Gynecology Hosp. Fudan University ( Site 4041)

location_facility: Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 2121)

location_facility: Azienda Ospedaliera Universitaria Federico II ( Site 2123)

location_facility: Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 4034)

location_facility: Azienda Ospedaliera Spedali Civili di Brescia ( Site 2135)

location_facility: Xiangya Hospital Central-South University ( Site 4035)

location_facility: Odense Universitetshospital ( Site 2512)

location_facility: Taichung Veterans General Hospital ( Site 4094)

location_facility: Medizinische Universitaet Innsbruck ( Site 2001)

location_facility: Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2355)

location_facility: Severance Hospital Yonsei University Health System ( Site 4062)

location_facility: Harbin Medical University Cancer Hospital ( Site 4033)

location_facility: Edith Wolfson Medical Center ( Site 2306)

location_facility: The Municipal Enterprise Volyn Regional Medical Oncology Centre ( Site 2362)

location_facility: Swietokrzyskie Centrum Onkologii SPZOZ ( Site 2485)

location_facility: Fundacion Arturo Lopez Perez FALP ( Site 1062)

location_facility: Instituto de Oncologia de Rosario ( Site 1004)

location_facility: Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2646)

location_facility: Baskent Universitesi Ankara Hastanesi ( Site 2354)

location_facility: Arkhangelsk Clinical Oncological Dispensary ( Site 2637)

location_facility: IRCCS Ospedale San Raffaele ( Site 2130)

location_facility: Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2366)

location_facility: Chelyabinsk Regional Clinical Center Oncology and Nuclear Medicine ( Site 2644)

location_facility: Aalborg Universitetshospital ( Site 2511)

location_facility: Rigshospitalet University Hospital ( Site 2515)

location_facility: Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 2132)

location_facility: Tomsk Scientific Research Institute of Oncology-Chemotherapy ( Site 2638)

location_facility: Iwate Medical University Hospital ( Site 4189)

location_facility: National Hospital Organization Kyushu Cancer Center ( Site 4193)

location_facility: Karolinska Universitetssjukhuset Solna ( Site 2220)

location_facility: SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2486)

location_facility: Hospital San Lucas Cardiologica del Sureste ( Site 1122)

location_facility: Bristol Haematology and Oncology Centre ( Site 2244)

location_facility: University of Massachusetts Medical School ( Site 3037)

location_facility: Universitetssjukhuset i Linkoping. ( Site 2222)

location_facility: University of Iowa Hospital and Clinics ( Site 3046)

location_facility: WK Physicians Network/Gynecologic Oncology Associates ( Site 3047)

location_facility: Hospital Universitario La Paz ( Site 2186)

location_facility: Hospital Clinic i Provincial ( Site 2185)

location_facility: Instituto de Investigaciones Clinicas Mar del Plata ( Site 1003)

location_facility: Institut De Cancerologie De Lorraine ( Site 2072)

location_facility: Linkou Chang Gung Memorial Hospital ( Site 4091)

location_facility: Instituto Nacional de Cancerologia ( Site 1124)

location_facility: National Hospital Organization Shikoku Cancer Center ( Site 4181)

location_facility: Athens University Hospital ATTIKON ( Site 2424)

location_facility: Norton Cancer Institute - St. Matthews ( Site 3056)

location_facility: CHU Besancon - Hopital Jean Minjoz ( Site 2068)

location_facility: MNE "Khmelnytskyi regional antitumor center" ( Site 2365)

location_facility: The First Bethune Hospital of Jilin University ( Site 4057)

location_facility: Smilow Cancer Hospital at Yale New Haven ( Site 3070)

location_facility: Arizona Oncology Associates PC- HOPE ( Site 3049)

location_facility: Centro Oncologico Riojano Integral ( Site 1007)

location_facility: Institut Regional du Cancer de Montpellier - ICM ( Site 2069)

location_facility: Saitama Medical University International Medical Center ( Site 4182)

location_facility: Aichi Cancer Center Hospital ( Site 4190)

location_facility: The First Affiliated Hospital ( Site 4043)

location_facility: Indiana University Melvin and Bren Simon Cancer Center ( Site 3071)

location_facility: Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2631)

location_facility: Legacy Good Samaritan Medical Center ( Site 3033)

location_facility: Castle Hill Hospital-Academic Oncology ( Site 2252)

location_facility: Sanford Gynecology Oncology ( Site 3045)

location_facility: Tampere University Hospital ( Site 2541)

location_facility: The First Affiliated Hospital of Wenzhou Medical University ( Site 4056)

location_facility: Medizinische Universitat Graz ( Site 2004)

location_facility: Kingston Health Sciences Centre ( Site 3003)

location_facility: Northwestern Memorial Hospital ( Site 3044)

location_facility: Samara Regional Clinical Oncology Center-Chemotherapy Dapartment ( Site 2649)

location_facility: Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur

location_facility: University of the Ryukyus Hospital ( Site 4184)

location_facility: IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 1010)

location_facility: Clínica Vida Fundación - Sede Poblado ( Site 1096)

location_facility: FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 2634)

location_facility: Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 3076)

location_facility: C.I.U. Hopital Ambroise Pare ( Site 2039)

location_facility: Bialostockie Centrum Onkologii ( Site 2483)

location_facility: Nanjing Drum Tower Hospital ( Site 4037)

location_facility: Oslo Universitetssykehus Radiumhospitalet ( Site 2151)

location_facility: Euromedica General Clinic of Thessaloniki ( Site 2422)

location_facility: I Can Oncology Center SA de CV ( Site 1126)

location_facility: University Hospital of North Norway ( Site 2153)

location_facility: University of Alabama - Birmingham ( Site 3061)

location_facility: Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 2249)

location_facility: McGill University Health Centre ( Site 3005)

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2122)

location_facility: Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2482)

location_facility: Perifereiako Geniko Nosokomeio ALEXANDRA ( Site 2425)

location_facility: Centre Hospitalier Lyon Sud ( Site 2064)

location_facility: National Cancer Center Hospital East ( Site 4197)

location_facility: LISOD - Israeli Oncological Hospital MedX-ray International Group, LLC ( Site 2364)

location_facility: Tianjin Medical University Cancer Institute & Hospital ( Site 4054)

location_facility: Taipei Veterans General Hospital ( Site 4093)

location_facility: I.E.U. Medical Point Hastanesi ( Site 2356)

location_facility: Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 4001)

location_facility: The First Affiliated Hospital of Xiamen University ( Site 4060)

location_facility: Lviv State Regional Oncological Center ( Site 2361)

location_facility: Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 2481)

location_facility: Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 2484)

location_facility: Hospital Clinico San Carlos ( Site 2187)

location_facility: Nizhegorodsky Regional Oncology Dispensary-chemotherapy department (Branch№1) ( Site 2639)

location_facility: UT Southwestern Medical Center ( Site 3063)

location_facility: Universitätsklinikum Bonn-Gynaecological oncology ( Site 2103)

location_facility: Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2105)

location_facility: The Cancer Institute Hospital of JFCR ( Site 4196)

location_facility: Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3080)

location_facility: Centro de Oncología e Investigación de Buenos Aires ( Site 1005)

location_facility: Centro Oncologico Internacional. SEDNA ( Site 1121)

location_facility: Investigacion Onco Farmaceutica S de RL de CV ( Site 1127)

location_facility: Abington Hospital - Asplundh Cancer Center ( Site 3073)

location_facility: Vseobecna fakultni nemocnice v Praze ( Site 2391)

location_facility: Clinica Universitaria de Navarra ( Site 2181)

location_facility: Beatson West of Scotland Cancer Centre ( Site 2247)

location_facility: Hôpital Privé Des Côtes d'Armor ( Site 2063)

location_facility: Seoul National University Bundang Hospital ( Site 4063)

location_facility: Peking Union Medical College Hospital ( Site 4036)

location_facility: Fondazione Policlinico Universitario Agostino Gemelli ( Site 2124)

location_facility: Jiangxi Maternal and Child Health Hospital ( Site 4051)

location_facility: Hospital Universitario Reina Sofia ( Site 2183)

location_facility: The First Affiliated Hospital of Xi an Jiaotong University ( Site 4045)

location_facility: The First Affiliated Hospital, Zhejiang University-Gynecology ( Site 4002)

location_facility: Guangxi Medical University Affiliated Tumor Hospital ( Site 4049)

location_facility: Hadassah Medical Center. Ein Kerem ( Site 2303)

location_facility: Shanghai Renji Hospital Affiliated to Jiao Tong University ( Site 4053)

location_facility: Sidney Kimmel Cancer Center - Jefferson Health ( Site 3078)

location_facility: Changhua Christian Hospital ( Site 4095)

location_facility: National Research Ogarev Mordovia State University ( Site 2648)

location_facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 3042)

summary: The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS.


acronym: ADMIRE-CD-II

title: A Phase-III, Randomized, Double-blind, Parallel-group, Placebo-controlled, International, Multicentre Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Patients With Crohn's Disease Over a Period of 24 Weeks and a Follow-up Period up to 52 Weeks

lead_sponsor: Tigenix S.A.U.

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

location_country:
Denmark
Poland
Spain
Italy
United Kingdom
Canada
Sweden
Hungary
Puerto Rico
United States
France
Israel
Belgium
Germany
Czechia

location_facility: Hospital Universitario Puerta de Hierro Majadahonda

location_facility: AOU Policlinico di Modena - Gastroenterologia

location_facility: Istituto Clinico Humanitas Rozzano, IRCCS - IBD Center

location_facility: Morristown Medical Center - Gastroenterology

location_facility: Johns Hopkins Medicine - The Johns Hopkins Hospital

location_facility: Centre Hospitalier Universitaire De Toulouse - Hopital De Ra

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: CHRU De Lille - Hopital Claude Huriez - Hepato-Gastro-Enterologie

location_facility: Dartmouth Hitchcock Medical Center - Cancer Center

location_facility: Weill Medical College of Cornell University

location_facility: Hopital Saint Louis - Gastro-hepatoenterologie

location_facility: MH Egeszsegugyi Kozpont - Gasztroenterologiai Osztaly

location_facility: GZA ziekenhuizen - Campus Sint-Vincentius - Gastro-enterology

location_facility: Policlinico S. Orsola Malpighi, AOU di Bologna-U.O. di Medicina Interna.

location_facility: Medical College of Wisconsin Hub for Collaborative Medicine - Gastroenterology and Hepatology

location_facility: USF Health South Tampa Center for Advanced Healthcare

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie

location_facility: Linkoping University Hospital - Department of Surgery

location_facility: Azienda Ospedaliera Universitaria Integrata Verona (AOUI) -

location_facility: AZ Groeninge - Campus Kennedylaan - Gastro-enterology

location_facility: Kensington Screening Clinic - Gastroenterology

location_facility: UC Irvine Medical Center - Chao Family Comprehensive Cancer

location_facility: UT Southwestern Medical Center - Gastroenterology - Gastroenterology

location_facility: Baylor College of Medicine (BCM) - Gastroenterology

location_facility: Hadassah Medical Organization, Hadassah Medical Center, Ein-

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - I. sz. Belgyogyaszati Klinika

location_facility: Policlinico Universitario Campus Biomedico - UOC di Gastroenterologia

location_facility: Penn State Hershey Medical Center - Surgery

location_facility: University of Massachusetts - colon & rectal surgery

location_facility: University Surgical Associates-Rhode Island Hospital

location_facility: Mount Sinai Hospital - Toronto - Gastroenterology

location_facility: The University of Chicago Medicine - Colon & Rectal Surgery

location_facility: CHRU de Nancy -Hopital Brabois Adultes - Service d'Hepato- Gastroenterologie

location_facility: Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow

location_facility: Centre Hospitalier de l'Universite de Montreal

location_facility: Virginia Mason Medical Center - Gastroenterology

location_facility: University of Southern California (USC) Norris Comprehensive Cancer Center

location_facility: Nottingham University Hospitals NHS Trust - Surgery

location_facility: McGill University Health Centre - Montreal General Hospital

location_facility: Aarhus University Hospital - Department of Hepatology and Gastroenterology, Lever-Mave- og Tarmsygdomme Klinik, krydspunkt C216

location_facility: University Colleague London Hospital (UCLH)

location_facility: Klinikum der Johann Wolfgang Goethe-Universitat

location_facility: North Shore University Hospital - Gastroenterology

location_facility: Shaare Zedek Medical Center - Gastroenterology

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Barnes-Jewish Hospital - Gastroenterology

location_facility: Harvard Medical School-Beth Israel Deaconess Medical Center

location_facility: Klinikum der Universitat Munchen - Campus Grosshadern

location_facility: Azienda Ospedaliero Universitaria S.Maria della Misericordia - Gastroenterologia

location_facility: University of Kansas Sxchool of Medicine

location_facility: University of Puerto Rico School of Medicine

location_facility: Mayo Clinic College of Medicine - Division of Colon and Rectal Surgery - Division of Colon and Rectal Surgery

location_facility: CHU de Liege - Domaine Universitaire du Sart Tilman

location_facility: NHS Greater Glasgow and Clyde - Glasgow Royal Infirmary (GRI)

summary: The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in at least 2 dimensions) confirmed by blinded central magnetic resonance imaging (MRI) assessment at Week 24.


title: A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Ulcerative Colitis

lead_sponsor: AbbVie

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

location_country:
Croatia
Serbia
Spain
Italy
United Kingdom
Lithuania
Ukraine
United States
Belgium
Japan
Romania
South Africa
Czechia
Poland
Portugal
Slovenia
Austria
Russian Federation
Argentina
Puerto Rico
Israel
Turkey
Mexico
Malaysia
Singapore
Sweden
Slovakia
Egypt
Brazil
Canada
Switzerland
China
Germany
Bulgaria
Denmark
Taiwan
Greece
Latvia
New Zealand
Korea, Republic of
France
Chile
Colombia
Netherlands

location_facility: Robley Rex VA Medical Center /ID# 218648

location_facility: CHU Montpellier - Hôpital Saint Eloi /ID# 223779

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 159443

location_facility: The Chaim Sheba Medical Center /ID# 211278

location_facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 164041

location_facility: Showa University Fujigaoka Hospital /ID# 209555

location_facility: Hospital Universitario de Salamanca /ID# 159446

location_facility: Faculdade de Medicina do ABC /ID# 163995

location_facility: Quality Clinical Research Inc. /ID# 167313

location_facility: Fırat University Medical Facul /ID# 171292

location_facility: Baylor College of Medicine - Baylor Medical Center /ID# 158221

location_facility: National Hospital Organization Hirosaki General Medical Center /ID# 164252

location_facility: Ospedale Sant Orsola Malpighi /ID# 155611

location_facility: Klinicki bolnicki centar Zagreb /ID# 201917

location_facility: Osaka Medical and Pharmaceutical University Hospital /ID# 226035

location_facility: CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 169108

location_facility: Advanced Research Institute, Inc /ID# 161938

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 217480

location_facility: Taichung Veterans General Hospital /ID# 163649

location_facility: Southern Star Research Institute, LLC /ID# 168776

location_facility: Immanuel Kant Baltic Federal University /ID# 204888

location_facility: Ospedale Policlinico San Martino /ID# 164031

location_facility: Health Pharma Professional Research S.A de C.V /ID# 203597

location_facility: West China Hospital, Sichuan University /ID# 211276

location_facility: South Florida Research Ph I-IV, Inc. /ID# 161848

location_facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 159440

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224099

location_facility: Hospital Nossa Senhora das Graças /ID# 157671

location_facility: Medical Research Center of CT /ID# 160311

location_facility: Azienda Ospedaliero-Universitaria di Modena /ID# 201819

location_facility: University Hospital Southampton NHS Foundation Trust /ID# 210813

location_facility: Centex Studies, Inc. - Houston /ID# 201222

location_facility: Shiga University of Medical Science Hospital /ID# 164440

location_facility: Nagasaki University Hospital /ID# 202674

location_facility: Medizinische Universitaet Graz /ID# 169053

location_facility: Japanese Red Cross Wakayama Medical Center /ID# 171195

location_facility: Taipei Veterans General Hosp /ID# 163650

location_facility: International Medical Center SOGAZ /ID# 206727

location_facility: St.Luke's International Hospital /ID# 225822

location_facility: Universitatsklinikum Mannheim /ID# 162035

location_facility: Duplicate_Universitaetsklinikum St.Poelten /ID# 169048

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226793

location_facility: Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202266

location_facility: Fakultni nemocnice u sv. Anny v Brne /ID# 239157

location_facility: CHU UCL Namur - site Godinne /ID# 200254

location_facility: Hospital Alvaro Cunqueiro CHUVI /ID# 167360

location_facility: Soroka University Medical Center /ID# 171100

location_facility: Nemocnice Ceske Budejovice a.s. /ID# 225226

location_facility: Atlanta Gastroenterology Spec /ID# 161372

location_facility: Precision Research Institute, LLC /ID# 201351

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 209977

location_facility: Kaiser Clinica e Hospital Dia /ID# 157680

location_facility: Peak Gastroenterology Associates, PC /ID# 165841

location_facility: Inje University Haeundae Hospital /ID# 203028

location_facility: Kanazawa University Hospital /ID# 169224

location_facility: Lenus Research & Medical Group /ID# 169730

location_facility: Nara Medical University Hospital /ID# 169225

location_facility: Columbia Univ Medical Center /ID# 161934

location_facility: The Second Hospital of Hebei Medical University /ID# 213018

location_facility: Interdisctrict Multidisciplinary Hospital /ID# 203335

location_facility: The University of Chicago Medical Center /ID# 160521

location_facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 167207

location_facility: General Hospital of Athens Laiko /ID# 206440

location_facility: Medizinische Universitaet Wien /ID# 169050

location_facility: ASST Grande Ospedale Metropolitano Niguarda /ID# 170947

location_facility: The Sixth Affiliated Hosp Sun /ID# 211231

location_facility: CHU Bordeaux - Hopital Haut Leveque /ID# 171579

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 160472

location_facility: Cotton-O'Neil Clinical Res Ctr /ID# 160412

location_facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 166551

location_facility: Sjællands Universitetshospital /ID# 200033

location_facility: Royal Devon and Exeter NHS Trust Hospital /ID# 157587

location_facility: Colo-proctology Center Matsushima Clinic /ID# 225914

location_facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 200685

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163395

location_facility: CHU Amiens-Picardie Site Sud /ID# 171576

location_facility: Yokkaichi Hazu Medical Center /ID# 164441

location_facility: Huai'an First People's Hospital /ID# 239196

location_facility: Texas Digestive Disease Consultants /ID# 209798

location_facility: Tzaneio general hospital of Piraeus /ID# 206439

location_facility: Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 200252

location_facility: Renmin Hospital of Wuhan University /ID# 212868

location_facility: WIP Warsaw IBD Point Profesor Kierkus /ID# 216102

location_facility: Rocky Mountain Pediatric Gastroenterology /ID# 207174

location_facility: St. Marianna University Hospital /ID# 226728

location_facility: London Health Sciences Center /ID# 169103

location_facility: Toronto Digestive Disease Asso /ID# 169106

location_facility: Houma Digestive Health Special /ID# 158317

location_facility: Omega Research Maitland, LLC /ID# 203059

location_facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 165218

location_facility: KL Ling Gastroenterology and Liver Clinic /ID# 205738

location_facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 171580

location_facility: Scott Shulman Medicine Professional Corporation /ID# 169113

location_facility: Duplicate_Centrul Medical Tuculanu SRL /ID# 171268

location_facility: Gokeikai Ofuna Chuo Hospital /ID# 169300

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 170601

location_facility: Erciyes University Medical Fac /ID# 171291

location_facility: ProMedica Physicians Digestive Healthcare /ID# 215623

location_facility: Digestive Disease Specialists /ID# 170779

location_facility: Second Multiprofile Hospital f /ID# 200799

location_facility: Hospital Universitario Reina Sofia /ID# 167058

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 164347

location_facility: Klinicki bolnicki centar Zagreb /ID# 157471

location_facility: Universitaetsklinikum Regensburg /ID# 163686

location_facility: Hospital Universitario San Vic /ID# 171490

location_facility: Plains Clinical Research Center, LLC /ID# 169732

location_facility: Sisli Etfal Train & Res Hosp /ID# 171409

location_facility: Central Clinical Hospital RZHD Medicine /ID# 204917

location_facility: Texas Digestive Disease Consultants /ID# 209950

location_facility: Saiseikai Fukuoka Genaral Hospital /ID# 225639

location_facility: Kitasato University Hospital /ID# 169226

location_facility: Royal Victoria Hospital / McGill University Health Centre /ID# 169104

location_facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169385

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 202059

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 170714

location_facility: Universitaetsklinikum Freiburg /ID# 162034

location_facility: Digestive Disease Associates, LTD /ID# 232407

location_facility: The First Affiliated Hospital of Anhui Medical University /ID# 211228

location_facility: Inonu Universitesi Turgut Ozal /ID# 203981

location_facility: Sahlgrenska University Hospital Molndal /ID# 202843

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159360

location_facility: Hospital Clinic de Barcelona /ID# 159439

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 200848

location_facility: Ulyanovsk Regional Clinical Hospital /ID# 203368

location_facility: Clinical Research Trials of Florida, Inc. /ID# 201783

location_facility: Centro Hospitalar de Entre Douro e Vouga /ID# 166052

location_facility: Tsujinaka Hospital Kashiwanoha /ID# 208964

location_facility: Agaplesion Markus Krankenhaus /ID# 159356

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210761

location_facility: The Catholic University of Korea, ST. Vincent's Hospital /ID# 158706

location_facility: King's College Hospital NHS Foundation Trust /ID# 158766

location_facility: VA Caribbean Healthcare System /ID# 221245

location_facility: University of Rochester Medical Center /ID# 161664

location_facility: Gastroenterology Consultants of Southwest Virginia /ID# 218143

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 169767

location_facility: Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 206937

location_facility: Sapporo Higashi Tokushukai Hospital /ID# 208488

location_facility: Pusan National University Hospital /ID# 158711

location_facility: University Clinical Center Serbia /ID# 200152

location_facility: Hiroshima University Hospital /ID# 164426

location_facility: Caprock Gastro Research, LLC /ID# 215432

location_facility: Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 171226

location_facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 215320

location_facility: Servicio de Salud Araucanía Norte Hospital Victoria /ID# 213151

location_facility: Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 163992

location_facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157679

location_facility: Hospital Garcia de Orta, EPE /ID# 165583

location_facility: CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 224343

location_facility: Toho University Sakura Medical Center /ID# 164254

location_facility: Linkou Chang Gung Memorial Hospital /ID# 222877

location_facility: Hyogo Medical University Hospital /ID# 164424

location_facility: Virginia Mason Medical Center /ID# 160466

location_facility: Atrium Health Carolinas Medical Center /ID# 158512

location_facility: CHRU Nancy - Hopitaux de Brabois /ID# 200095

location_facility: Hospital Universitario Miguel Servet /ID# 159445

location_facility: Tyler Research Institute, LLC /ID# 166800

location_facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157660

location_facility: Louisana Research Center, LLC /ID# 201204

location_facility: Fukuoka University Chikushi Hospital /ID# 209055

location_facility: Percuro Clinical Research, Ltd /ID# 169109

location_facility: CNE Regional Clinical Hospital of Ivano-Frankivsk RC /ID# 203367

location_facility: Clin Res Inst of Michigan, LLC /ID# 160327

location_facility: National Hospital Organization Takasaki General Medical Center /ID# 164437

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 211025

location_facility: Hospital de Clinicas de Porto Alegre /ID# 157662

location_facility: Manhattan Clinical Research, LLC /ID# 211805

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 224348

location_facility: Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211071

location_facility: Aichi Medical University Hospital /ID# 164332

location_facility: Universitair Ziekenhuis Leuven /ID# 170812

location_facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162033

location_facility: South Lake Pain Institute, Inc /ID# 162878

location_facility: Shengjing Hospital of China Medical University /ID# 211646

location_facility: Klinicki bolnicki centar Split /ID# 157473

location_facility: Hospital Universitario Virgen Macarena /ID# 159968

location_facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210962

location_facility: Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 210510

location_facility: The First Hospital of Jilin University /ID# 212278

location_facility: Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 215504

location_facility: Adult Gastroenterology Associates - Gen 1 Research /ID# 208867

location_facility: Universitaetsklinikum Erlangen /ID# 159354

location_facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 203512

location_facility: Yonsei University Health System Severance Hospital /ID# 158701

location_facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 165580

location_facility: UCSF Center for Colitis and Crohn's Disease /ID# 201210

location_facility: Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Panstwowy Instytut Bada /ID# 170600

location_facility: Inselspital, Universitätsspital Bern /ID# 202911

location_facility: Praxis fuer Gastroenterologie /ID# 166152

location_facility: Hamamatsu University Hospital /ID# 226727

location_facility: Ctr for Advanced Gastroenterol /ID# 202811

location_facility: Cleveland Clinic Main Campus /ID# 209232

location_facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171293

location_facility: Sapporo Medical University Hospital /ID# 164432

location_facility: Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 211064

location_facility: China Medical University Hospital /ID# 160189

location_facility: Pauls Stradins Clinical University Hospital /ID# 163803

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155612

location_facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 203595

location_facility: Fondazione PTV Policlinico Tor Vergata /ID# 158018

location_facility: Kuzbass Regional Clinical Hospital /ID# 165750

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 165581

location_facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159461

location_facility: Penn State Milton S. Hershey Medical Center /ID# 223563

location_facility: Ponce Medical School Foundation /ID# 221244

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 164251

location_facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 219145

location_facility: General Hospital of Ningxia Medical University /ID# 213911

location_facility: Tokyo Medical And Dental University Hospital /ID# 164258

location_facility: Kitasato University Kitasato Institute Hospital /ID# 164256

location_facility: Complejo Hospitalario Universitario de Pontevedra /ID# 216182

location_facility: Hoag Memorial Hosp Presbyterian /ID# 218348

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170915

location_facility: Hadassah Medical Center-Hebrew University /ID# 171099

location_facility: Bispebjerg and Frederiksberg Hospital /ID# 208945

location_facility: Hospital Privado Univesitario /ID# 167779

location_facility: The First Affiliated Hospital of Nanchang University /ID# 212183

location_facility: Yamagata University Hospital /ID# 171474

location_facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 227457

location_facility: St George's University Hospitals NHS Foundation Trust /ID# 208378

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 211233

location_facility: Cambridge University Hospitals NHS Foundation Trust /ID# 158040

location_facility: A.O. Per L'Emergenza Cannizzaro /ID# 164036

location_facility: Southern California Res. Ctr. /ID# 169660

location_facility: Centro Hospitalar e Universitario de Coimbra, EPE /ID# 166054

location_facility: Massachusetts General Hospital - Crohn's and Colitis Center /ID# 164255

location_facility: Gastroenterologie Opernstrasse /ID# 163683

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 160523

location_facility: Chu de Nice-Hopital L'Archet Ii /Id# 171577

location_facility: Cabinet Particular Policlinic Algomed /ID# 171266

location_facility: Groupe Sante CHC - Clinique du MontLegia /ID# 200250

location_facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226794

location_facility: Barnsley Hospital NHS Foundation Trust /ID# 202770

location_facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 165582

location_facility: Liverpool University Hospitals NHS Foundation Trust /ID# 203858

location_facility: ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155607

location_facility: Great Lakes Medical Research, LLC /ID# 201777

location_facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 200931

location_facility: General Hospital of Athens Ippokratio /ID# 229189

location_facility: DM Clinical Research/Southwest /ID# 165012

location_facility: H-T. Centrum Medyczne - Endoterapia /ID# 230979

location_facility: Asahikawa Medical University Hospital /ID# 164433

location_facility: Yale Univ Digestive Diseases /ID# 213179

location_facility: Tokai University Hachioji Hospital /ID# 226899

location_facility: Praxiszentrum fuer Gastroenterologie /ID# 219069

location_facility: Theageneio Anticancer Hospital /ID# 165217

location_facility: Centro Hosp de Tondela-Viseu /ID# 166053

location_facility: The Jikei University Hospital /ID# 164434

location_facility: The Second Xiangya Hospital of Central South University /ID# 211198

location_facility: Private Practice Dr MN Rajabally /ID# 171137

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 158524

location_facility: Vanderbilt University Medical Center /ID# 160580

location_facility: Clinic of New Technologies of Medicine /ID# 203369

location_facility: Gastroenterology Group Naples /ID# 165212

location_facility: Yeungnam University Medical Center /ID# 158703

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 158041

location_facility: CHA University Bundang Medical Center /ID# 158710

location_facility: UOC Medicina Interna e Gastroe /ID# 155608

location_facility: DiGiovanna Institute for Medical Education & Research /ID# 171129

location_facility: Nagoya City University Hospital /ID# 164331

location_facility: Wakayama Medical University Hospital /ID# 169487

location_facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 211449

location_facility: Hospital Provincial del Centenario /ID# 170898

location_facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 242378

location_facility: East Tennessee Research Institute /ID# 168747

location_facility: Fujita Health University Hospital /ID# 164261

location_facility: Clinical Hosp Center Zvezdara /ID# 200151

location_facility: Elisabeth Tweesteden Ziekenhuis /ID# 163767

location_facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 224926

location_facility: National Taiwan University Hospital /ID# 162187

location_facility: Tongji Hospital Tongji Medical College of HUST /ID# 211072

location_facility: Uludag University Medical Faculty /ID# 204182

location_facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 161376

location_facility: Regional Clinical Hospital #1 /ID# 165754

location_facility: Hospital Universitario La Paz /ID# 159459

location_facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159361

location_facility: Hayang University GuriHospital /ID# 158702

location_facility: First Moscow State Medical University n.a I.M. Sechenov /ID# 204978

location_facility: Air Force Specialized Hospital /ID# 170986

location_facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204130

location_facility: Vilnius University Hospital Santaros Klinikos /ID# 170614

location_facility: Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 224350

location_facility: GBUZ Allergology and Immunology Center of Ministry of Health of Kabardino-Bal /ID# 233973

location_facility: LMU Klinikum Campus Grosshadern /ID# 210481

location_facility: CliniCore International, LLC /ID# 158218

location_facility: Cedars-Sinai Medical Center-West Hollywood /ID# 163851

location_facility: Stadtisches Klinikum Braunschweig /ID# 163687

location_facility: Gastro Health & Nutrition - Victoria /ID# 164321

location_facility: Chung Shan Medical University Hospital /ID# 163651

location_facility: Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171125

location_facility: Centre Médico Chirurgical Ambroise Paré Hartmann /ID# 249860

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 165216

location_facility: Wellington Regional Hospital /ID# 205343

summary:
The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in Sub-Study 2.

The objective of Sub-Study 2 is to evaluate the efficacy and safety of risankizumab compared to placebo in inducing clinical remission in subjects with moderately to severely active UC.


title: A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects With Light Chain (AL) Amyloidosis

acronym: AFFIRM-AL

summary: A Phase 3 study to evaluate the efficacy and safety of birtamimab plus standard of care compared to placebo plus standard of care in patients with AL amyloidosis in Mayo Stage IV.

lead_sponsor: Prothena Biosciences Ltd.

location_country:
Spain
Italy
United Kingdom
United States
Japan
Czechia
Poland
Portugal
Australia
Israel
Turkey
Canada
Hungary
Germany
Denmark
Taiwan
Greece
Ireland
Korea, Republic of
France
Netherlands

location_facility: University Hospital Marqués de Valdecilla

location_facility: Chonnam National University Hwasun Hospital

location_facility: The Catholic University of Korea - Seoul St. Mary's Hospital

location_facility: Theagenio Anti-Cancer Hospital of Thessaloniki

location_facility: Clinica Universidad de Navarra - Pamplona

location_facility: Froedtert and Medical College of Wisconsin

location_facility: Rabin Medical Center - Beilinson Hospital

location_facility: Smilow Cancer Hospital Care Center at Trumbull

location_facility: University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

location_facility: Semmelweis Egyetem - I. sz. Belgyógyászati Klinika

location_facility: University of Michigan Rogel Cancer Center

location_facility: Uniwersyteckie Centrum Kliniczne w Gdańsku

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: Institut Català d'Oncologia - Hospital Germans Trias i Pujol

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust

location_facility: The Ohio State University College of Medicine

location_facility: Wake Forest Baptist Health - Comprehensive Cancer Center

location_facility: Manchester University NHS Foundation Trust

location_facility: Hospital Universitari i Politècnic la Fe

location_facility: Centro Hospitalar e Universitário de Coimbra

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Di Ancona

location_facility: Institut Català d'Oncologia - Hospital Duran i Reynals

location_facility: Centro Hospitalar Universitário Lisboa Norte - Hospital De Santa Maria

location_facility: Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet

location_facility: Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi

location_facility: Complejo Asistencial Universitario de Salamanca - Hospital Clínico

location_facility: Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele

location_facility: Nottingham University Hospitals NHS Trust

location_facility: Roswell Park Comprehensive Cancer Center

location_facility: Centre Hospitalier Universitaire Limoges

location_facility: Centre Hospitalier Universitaire Poitiers


title: TIGER-3: A Phase 3, Open-label, Multicenter, Randomized Study of Oral Rociletinib (CO-1686) Monotherapy Versus Single-agent Cytotoxic Chemotherapy in Patients With Mutant EGFR Non-small Cell Lung Cancer (NSCLC) After Failure of at Least 1 Previous EGFR-directed Tyrosine Kinase Inhibitor (TKI) and Platinum-doublet Chemotherapy

summary: The purpose of this study is to compare the anti-tumor efficacy of oral single-agent rociletinib, as measured by investigator assessment of the PFS, with that of single-agent cytotoxic chemotherapy in patients with EGFR-mutated, advanced/metastatic NSCLC after failure of at least 1 previous EGFR-directed TKI and at least 1 line of platinum-containing doublet chemotherapy.

lead_sponsor: Clovis Oncology, Inc.

location_country:
Taiwan
Spain
Italy
United Kingdom
Australia
Netherlands
Korea, Republic of
United States
France
Germany

location_facility: Sylvester Comprehensive Cancer Center (UMHC)

location_facility: University of Pittsburgh Cancer Institute (UPMC)

location_facility: Chonnam National University Hwasun Hospital

location_facility: Oregon Health & Science University (OHSU) - Knight Cancer Institute

location_facility: The Ohio State University Comprehensive Cancer Center

location_facility: University of California San Diego Moores Cancer Center

location_facility: The Catholic University of Korea Saint Vincent's Hospital

location_facility: L'Assistance Publique - Hopitaux de Marseille

location_facility: University of California, San Francisco Helen Diller Family Comprehensive Cancer Center

location_facility: Seoul National University Bundang Hospital

location_facility: Central Coast Medical Oncology Corporation

location_facility: University of Florida Health Science Center

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: Walter Reed National Military Medical Center

location_facility: Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou

location_facility: IRCCS Azienda Ospedaliera Universitaria San Martino - IST

location_facility: The Oncology Institute of Hope and Innovation

location_facility: Hospital Regional Universitario Carlos Haya

location_facility: University of Texas Southwestern Medical Center

location_facility: Fundacion Jimenez Diaz (Clinica de la Concepcion) (UAM -FJD)

location_facility: Centre Hospitalier Intercommunal Créteil

location_facility: Guy's and Saint Thomas NHS Foundation Trust

location_facility: Cancer Care Associates Medical Group, Inc.


title: Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous and Endometrioid Ovarian Cancer (ARIEL3)

ReferenceCitation: Green ML, Ma SC, Goble S, Giordano H, Maloney L, Simmons AD, Beltman J, Harding TC, Xiao JJ. Population pharmacokinetics of rucaparib in patients with advanced ovarian cancer or other solid tumors. Cancer Chemother Pharmacol. 2022 May;89(5):671-682. doi: 10.1007/s00280-022-04413-7. Epub 2022 Apr 10.

ReferenceCitation: Tattersall A, Ryan N, Wiggans AJ, Rogozińska E, Morrison J. Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Cochrane Database Syst Rev. 2022 Feb 16;2:CD007929. doi: 10.1002/14651858.CD007929.pub4. Review.

ReferenceCitation: Colombo N, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Meunier J, Cameron T, Maloney L, Goble S, Bedel J, Ledermann JA, Coleman RL. The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma. Gynecol Oncol. 2020 Oct;159(1):101-111. doi: 10.1016/j.ygyno.2020.05.045. Epub 2020 Aug 26.

ReferenceCitation: Ledermann JA, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp AR, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Cameron T, Maloney L, Goble S, Coleman RL. Rucaparib for patients with platinum-sensitive, recurrent ovarian carcinoma (ARIEL3): post-progression outcomes and updated safety results from a randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2020 May;21(5):710-722. doi: 10.1016/S1470-2045(20)30061-9.

ReferenceCitation: Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators. Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2017 Oct 28;390(10106):1949-1961. doi: 10.1016/S0140-6736(17)32440-6. Epub 2017 Sep 12. Erratum in: Lancet. 2017 Oct 28;390(10106):1948.

location_country:
Spain
Italy
United Kingdom
Australia
New Zealand
Canada
United States
France
Israel
Belgium
Germany

location_facility: Karmanos Cancer Institute - Wayne State University

location_facility: Oncology Unit City Hospital degli Infermi

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: CHUM Centre Hospitalier de l'Université de Montréal

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Centro Integral Oncológico Clara Campal, Hospital de Madrid Norte-San Chinarro

location_facility: Instituto Valencia de Oncologia-Fundacion

location_facility: Oncology Institute, Sheba Medical Center

location_facility: Dr. Horst Schmidt Klinik, Klinik fuer Gynaekologie und Gyn. Onkologie

location_facility: Washington University School of Medicine - Division of Gynaecological Oncology

location_facility: University of California San Francisco (UCSF)

location_facility: University of Texas MD Anderson Cancer Center

location_facility: Fondazione IRCCS National Cancer Institute

location_facility: The Ohio State University Wexner Medical Center

location_facility: Centre Hospitalier Universitaire de Québec

location_facility: Azienda Ospedaliero Universitaria Policlinico di Modena

location_facility: Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi

location_facility: Istituto Nazionale Tumori IRCCS Fondazione Pascale

location_facility: University of California Los Angeles (UCLA)

location_facility: Sir Bobby Robson Cancer trials research Centre, Northern Centre For Cancer Care

location_facility: Hospital Regional Universitario Carlos Haya de Malaga

summary: Patients enrolled into this study will be stratified into 3 groups based on gene mutations identified in their tumor tissue. The purpose of this study is to evaluate patient response to maintenance treatment with rucaparib versus placebo. Response to treatment will be analyzed based on homologous recombination (HR) status of tumor samples.


title: A Phase 2 Dose Ranging, Randomized, Double Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis (PBC) With or Without an Inadequate Response to Ursodeoxycholic Acid (UDCA)

summary: A randomized, double-blind study to assess the safety, tolerability, PK and efficacy of EDP-305 in subjects with primary biliary cholangitis

lead_sponsor: Enanta Pharmaceuticals, Inc

location_country:
Spain
United Kingdom
Austria
Australia
Netherlands
Canada
United States
France
Belgium
Germany

location_facility: Digestive Health Specialists of the Southeast

location_facility: American Research Corporation at the Texas Liver Institute

location_facility: Norfolk and Norwich University Hospitals NHS Foundation Trust

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: University of Pittsburgh Medical Center - Center for Liver Disease

location_facility: Universidad de Valladolid - Hospital Universitario Rio Hortega

location_facility: Cambridge University Hospitals NHS Foundation Trust

location_facility: South Denver Gastroenterology - Swedish Medical Center Office

location_facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

location_facility: Centre Hospitalier Régional Universitaire de Lille

location_facility: The Liver Institute at Methodist Dallas Medical Center

location_facility: Centre Hospitalier Universitaire Amines-Picardie Hôpital Sud

location_facility: University Hospitals Birmingham NHS Foundation Trust

location_facility: University of Iowa Hospitals and Clinics

location_facility: London Health Sciences Centre University Hospital

location_facility: King's College Hospital NHS Foundation Trust

location_facility: Hospital Universitario Virgen de la Arrixaca

location_facility: Gastroenterology Consultants of Clearwater

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: University of Miami Leonard M. Miller School of Medicine


title: A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

summary: Study 849-010 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

lead_sponsor: Mirati Therapeutics Inc.

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Czechia
Poland
Hong Kong
Portugal
Austria
Australia
Argentina
Puerto Rico
Mexico
Malaysia
Singapore
Brazil
Canada
China
Germany
Denmark
Taiwan
Greece
Ireland
Finland
Thailand
Korea, Republic of
France
Colombia
Netherlands


title: A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF Therapy

acronym: SEQUENCE

summary:
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. This study will evaluate how well risankizumab works compared to ustekinumab. This study will assess change in Crohn's Disease Activity Index (CDAI).

Risankizumab is an investigational drug being developed for the treatment of Crohn's Disease (CD). Ustekinumab is an approved drug for the treatment of moderate and severe CD. Participants are randomly assigned to one of the three treatment groups. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to ustekinumab. Around 508 adult participants with moderate to severe CD will be enrolled in approximately 307 sites worldwide.

In Part 1, participants assigned to risankizumab will receive intravenous (IV) doses of risankizumab at Week 0, 4,8 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. Participants assigned to ustekinumab will receive intravenous (IV) dose of ustekinumab at Week 0 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. In Part 2, participants who received risankizumab in Part 1 and completed the Week 48 visit will continue to receive SC risankizumab for up to an additional 220 weeks.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

location_country:
Spain
Italy
United Kingdom
Ukraine
United States
Belgium
Romania
South Africa
Czechia
Poland
Austria
Australia
Russian Federation
Argentina
Israel
Turkey
Mexico
Sweden
Slovakia
Brazil
Canada
Switzerland
Hungary
China
Germany
Bulgaria
Greece
Korea, Republic of
France
Chile
Netherlands

location_facility: CHRU Nancy - Hôpitaux de Brabois /ID# 223767

location_facility: Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 223902

location_facility: West Virginia University Hospitals /ID# 223501

location_facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 223768

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224580

location_facility: Penn State Milton S. Hershey Medical Center /ID# 224216

location_facility: Louisana Research Center, LLC /ID# 223503

location_facility: Hunter Holmes McGuire VA Medical Center /ID# 223586

location_facility: Kaiser Clinica e Hospital Dia /ID# 223232

location_facility: Shengjing Hospital of China Medical University /ID# 224478

location_facility: CHU de Nantes, Hotel Dieu -HME /ID# 241098

location_facility: Medical Center of LLC DIASERVIS /ID# 224249

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 223277

location_facility: Scott Shulman Medicine Professional Corporation /ID# 223754

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 223597

location_facility: Cabinet Particular Policlinic Algomed /ID# 223578

location_facility: Hospital Universitario Virgen Macarena /ID# 223315

location_facility: Digestive Disease Specialists /ID# 223528

location_facility: UMHAT Tsaritsa Joanna - ISUL /ID# 223822

location_facility: Inselspital, Universitätsspital Bern /ID# 223590

location_facility: Lenasia Clinical Trial Centre /ID# 224306

location_facility: Peking University Third Hospital /ID# 224479

location_facility: Nature Coast Clinical Research - Inverness /ID# 223600

location_facility: Hospital Italiano de Buenos Aires /ID# 224550

location_facility: University of California, San Francisco /ID# 223621

location_facility: Beth Israel Deaconess Medical Center /ID# 228094

location_facility: CINME Centro de Investigaciones Metabolicas /ID# 223447

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 224545

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 223773

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 223324

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 226554

location_facility: Karolinska University Hospital Solna /ID# 223423

location_facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 223499

location_facility: Plains Clinical Research Center, LLC /ID# 223522

location_facility: Acibadem City Clinic Tokuda University Hospital EAD /ID# 223757

location_facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 223327

location_facility: Private Practice Dr MN Rajabally /ID# 223805

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 224420

location_facility: The Second Xiangya Hospital of Central South University /ID# 224684

location_facility: Hoag Memorial Hosp Presbyterian /ID# 224373

location_facility: NHS Greater Glasgow and Clyde /ID# 223653

location_facility: Second Multiprofile Hospital f /ID# 223425

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 224662

location_facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 223508

location_facility: West China Hospital, Sichuan University /ID# 224786

location_facility: The Chaim Sheba Medical Center /ID# 223557

location_facility: North Shore University Hospital /ID# 224356

location_facility: Centro Medico Zambrano Hellion /ID# 224025

location_facility: Hospital Clinico Universitario San Carlos /ID# 223367

location_facility: Advanced Gastroenterology, P.C /ID# 224396

location_facility: Medical University of South Carolina /ID# 223485

location_facility: Southern Star Research Institute, LLC /ID# 223598

location_facility: Hospital Britanico de Buenos Aires /ID# 223432

location_facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 223403

location_facility: Medical Care & Research SA de CV /ID# 223974

location_facility: Wake Forest Baptist Medical Center /ID# 224406

location_facility: City Clinical Hospital No. 31 /ID# 224223

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 223497

location_facility: University Hospital Southampton NHS Foundation Trust /ID# 224351

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 223302

location_facility: Tongji Hospital Tongji Medical College of HUST /ID# 224428

location_facility: Policlinico Agostino Gemelli /ID# 223323

location_facility: Oxford University Hospitals NHS Foundation Trust /ID# 223645

location_facility: CHU Montpellier - Hôpital Saint Eloi /ID# 223860

location_facility: Azienda Ospedaliero Universitaria di Cagliari- Presidio Ospedaliero /ID# 223474

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 223395

location_facility: Hospital Clinic de Barcelona /ID# 223355

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 223256

location_facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 223340

location_facility: Royal Victoria Hospital / McGill University Health Centre /ID# 223743

location_facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 223654

location_facility: Texas Digestive Disease Consultants - Southlake /ID# 224264

location_facility: Faculdade de Medicina do ABC /ID# 223231

location_facility: CSSS Alphonse-Desjardins, CHAU de Levis /ID# 223744

location_facility: ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 223322

location_facility: Western Connecticut Medical Group /ID# 223478

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 223405

location_facility: Ospedale Policlinico San Martino /ID# 223329

location_facility: Cambridge University Hospitals NHS Foundation Trust /ID# 223648

location_facility: The University of Chicago DCAM /ID# 223520

location_facility: QEII - Health Sciences Centre /ID# 223748

location_facility: The Second Affiliated Hospital of Zhengzhou University /ID# 224528

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 223774

location_facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 224222

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 223319

location_facility: General Hospital of Athens Ippokratio /ID# 223344

location_facility: Columbia Univ Medical Center /ID# 224215

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 223482

location_facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 223411

location_facility: Zhujiang Hospital of Southern Medical University /ID# 224524

location_facility: The First Affiliated Hospital of Nanchang University /ID# 224507

location_facility: Nottingham University Hospitals NHS Trust /ID# 224179

location_facility: Hospital Universitario Germans Trias i Pujol /ID# 223436

location_facility: University of Vermont Medical Center /ID# 224047

location_facility: The Edith Wolfson Medical Center /ID# 227652

location_facility: Universitatsklinikum Mannheim /ID# 223410

location_facility: Hospital Universitario de Fuenlabrada /ID# 223371

location_facility: Radboud Universitair Medisch Centrum /ID# 233750

location_facility: Universitaetsklinikum Erlangen /ID# 223404

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 223765

location_facility: Universitair Medisch Centrum Utrecht /ID# 223696

location_facility: Southern California Res. Ctr. /ID# 223484

location_facility: Gazi Universitesi Tip Fakultes /ID# 223386

location_facility: Tyler Research Institute, LLC /ID# 223469

location_facility: Universitaetsklinikum Frankfurt /ID# 223396

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 223525

location_facility: Percuro Clinical Research, Ltd /ID# 223747

location_facility: Nemocnice Ceske Budejovice a.s. /ID# 224219

location_facility: Azienda Ospedaliera G. Brotzu /ID# 241165

location_facility: CHU Grenoble - Hopital Michallon /ID# 224091

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 223700

location_facility: Hospital Privado Univesitario /ID# 223433

location_facility: Assaf Harofeh Medical Center /ID# 224686

location_facility: CHU Reims - Hôpital Robert Debre /ID# 224530

location_facility: Centro de Investigacion en Artritis y Osteoporosis S.C. /ID# 227179

location_facility: Gastroenterology Group Naples /ID# 223516

location_facility: CHU UCL Namur - site Godinne /ID# 223905

location_facility: AA Medical Research Center - Grand Blanc /ID# 224384

location_facility: Consultants in Gastroenterology - Columbia NE /ID# 224263

location_facility: Medizinische Universitaet Wien /ID# 223438

location_facility: CHU Bordeaux - Hopital Haut Leveque /ID# 223764

location_facility: General Hospital of Thessaloniki Hippokrateio /ID# 223887

location_facility: Elisabeth Tweesteden Ziekenhuis /ID# 223229

location_facility: The Third Xiangya Hospital of Central South University /ID# 224754

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 223336

location_facility: Targu Mures Emergency Clinical County Hospital /ID# 223613

location_facility: Lviv Regional Clinical Hospital /ID# 223661

location_facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 223233

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 223755

location_facility: Hospital Universitario Central de Asturias /ID# 223368

location_facility: Medizinische Hochschule Hannover /ID# 223402

location_facility: Chu de Nice-Hopital L'Archet Ii /Id# 223763

location_facility: Soroka University Medical Center /ID# 223556

location_facility: Universitaetsklinikum St. Poelten /ID# 223437

location_facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 223465

location_facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine /ID# 224421

location_facility: Tel Aviv Sourasky Medical Center /ID# 223551

location_facility: Guys and St Thomas NHS Foundation Trust /ID# 223647

location_facility: Nemocnice Horovice - NH Hospital a.s /ID# 223276

location_facility: Intercity Advanced Gastroentertology Center /ID# 224313

location_facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 223333

location_facility: Hospital General Universitario Alicante /ID# 223552

location_facility: Hospital Universitario y Politecnico La Fe /ID# 223314

location_facility: King's College Hospital NHS Foundation Trust /ID# 223649

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 223342

location_facility: Cleveland Clinic Main Campus /ID# 223691

location_facility: Universitaetsklinikum Freiburg /ID# 223406

location_facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 223440

location_facility: Universitatsklinik Regensburg /ID# 223407

location_facility: Fondazione PTV Policlinico Tor Vergata /ID# 223332

location_facility: Virginia Mason Medical Center /ID# 224253

location_facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 223512

location_facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 223335

location_facility: Hospital Universitario de Bellvitge /ID# 225719

location_facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 223456

location_facility: Advanced Research Institute, Inc /ID# 223470

location_facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 223510

location_facility: Baylor College of Medicine - Baylor Medical Center /ID# 223488

location_facility: Renmin Hospital of Wuhan University /ID# 224525

location_facility: Hospital Universitario Virgen del Rocio /ID# 223476

location_facility: The Sixth Affiliated Hosp Sun /ID# 224416

location_facility: Groupe Sante CHC - Clinique du MontLegia /ID# 223898

location_facility: Hospital Universitario La Paz /ID# 223318

location_facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 224048

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 223325

location_facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 223387

location_facility: Massachusetts General Hospital /Id# 224335

location_facility: Hospital Clinico Universitario de Valencia /ID# 223321

location_facility: Yale Univ Digestive Diseases /ID# 224463

location_facility: East and North Hertfordshire NHS Trust /ID# 224607

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 223655

location_facility: NorthShore University HealthSystem /ID# 223538

location_facility: Immanuel Kant Baltic Federal University /ID# 224224

location_facility: Univ Emergency Hosp Bucharest /ID# 223579

location_facility: Omega Research Maitland, LLC /ID# 223463

location_facility: Zhongshan Hospital Xiamen University /ID# 224663

location_facility: Digestive Disease Associates, LTD /ID# 223462

location_facility: London Health Sciences Center /ID# 223741

location_facility: Changzhou No.2 People's Hospital /ID# 238965

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 223338

location_facility: Malopolskie Centrum Kliniczne /ID# 223708

location_facility: Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 224017

location_facility: Agaplesion Markus Krankenhaus /ID# 223673

location_facility: Royal Devon and Exeter NHS Trust Hospital /ID# 223644

location_facility: Universitair Ziekenhuis Leuven /ID# 223901

location_facility: Hopital Universitaire Purpan Hopital Rangueil /ID# 224732

location_facility: Medizinisches Versorgungszentrum Portal 10 /ID# 224552

location_facility: Sociedad de Servicios Medicos Walsen Galmez /ID# 224032

location_facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 223330

location_facility: Belfast Health and Social Care Trust /ID# 224023

location_facility: Praxiszentrum fuer Gastroenterologie /ID# 223409

location_facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 223356

location_facility: St George's University Hospitals NHS Foundation Trust /ID# 223656

location_facility: Medical Research Center of CT /ID# 223540

location_facility: University General Hospital of Ioannina /ID# 223339

location_facility: Hospital General Universitario Gregorio Maranon /ID# 223317

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 223668

location_facility: Northern Care Alliance NHS Group /ID# 223650

location_facility: Vanderbilt University Medical Center /ID# 224610