title: A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Breast Cancer Patients Whose Disease Has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)

summary: This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.

ipd_sharing_description: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

lead_sponsor: AstraZeneca

location_country:
Saudi Arabia
Italy
Spain
United Kingdom
United States
Belgium
Japan
Poland
Portugal
Austria
Australia
Russian Federation
Argentina
India
Israel
Mexico
Singapore
Sweden
Brazil
Canada
Hungary
China
Germany
Denmark
Taiwan
Korea, Republic of
France
Netherlands


ipd_sharing: No

status: Recruiting

primary_purpose: Other

intervention_type: Drug

acronym: Darolutamide roll-over study

title: An Open-label, Single Arm, Roll-over Study to Provide Continued Treatment With Darolutamide in Participants Who Were Enrolled in Previous Bayer Sponsored Studies

study_completion_date_type: Anticipated

lead_sponsor: Bayer

type: EudraCT Number

source: euctr

study_start_date_type: Actual

study_type: Interventional

ipd_sharing_description:
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014.

Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.

enrollment_type: Anticipated

location_country:
Serbia
Spain
Italy
United Kingdom
Lithuania
Ukraine
United States
Peru
Belgium
Japan
Romania
South Africa
Czechia
Poland
Portugal
Austria
Australia
Russian Federation
Argentina
Israel
Turkey
Mexico
Sweden
Slovakia
Brazil
Canada
Hungary
China
Germany
Bulgaria
Taiwan
Belarus
Latvia
Estonia
Finland
Korea, Republic of
France
Colombia
Netherlands

location_facility: Urologica Praktyka Lekarska Adam Marcheluk

location_facility: Institut du Cancer de Montpellier - Val d'Aurelle

location_facility: Kharkiv Medical Academy of postgraduate education

location_facility: Associação Hospitalar Beneficente São Vicente de Paulo

location_facility: National Medical Research Radiology Center

location_facility: ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis)

location_facility: SPZOZ Wojewodzki Szpital Specjalistyczny nr 3

location_facility: Associated Medical Professionals of NY, PLLC

location_facility: Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.

location_facility: Ironwood Physicians P.C. DBA Ironwood Cancer & Res. Ctr.

location_facility: Clalit Health Services Rabin Medical Center-Beilinson Campus

location_facility: The First Affiliated Hospital of Xi'an Jiaotong University

location_facility: Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina

location_facility: Tampereen yliopistollinen sairaala, keskussairaala

location_facility: Hosp Clínicas Facult. Med. de Ribeirão Preto / USP

location_facility: Tianjin Medical University Cancer Institiute & Hospital

location_facility: Riga East Clinical University Hospital "Gailezers"

location_facility: Hospital Clinico Universitario San Carlos | Oncologia

location_facility: Litavniece Dzintra practice in urology and oncological chem.

location_facility: IRCCS Fondazione del Piemonte per l'Oncologia

location_facility: Hospital Universitario Virgen de la Victoria | Oncology

location_facility: Minsk City Clinical Oncological Dispensary

location_facility: Universitätsmedizin der Johannes Gutenberg Universität Mainz

location_facility: National Hospital Organization Shinshu Ueda Medical Center

location_facility: TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has

location_facility: Liga Paranaense de Combate ao Cancer-Hosp Erasto Gaertner

location_facility: National hospital Organization Mito Medical Center

location_facility: Hospital of LT University of Health Sciences Kaunas Clinics

location_facility: Hospital Evangélico de Cachoeiro de Itapemirim

location_facility: St. Petersburg Medical University n.a. I.P. Pavlov

location_facility: IBCC - Instituto Brasileiro de Controle do Cancer

location_facility: Hospital Universitario "José Eleuterio González"

location_facility: Ciutat Sanitària i Universitaria de la Vall d'Hebron

location_facility: Gangnam Severance Hospital, Yonsei University Health System

location_facility: Hiroshima City Hiroshima Citizens Hospital

location_facility: VA Greater Los Angeles Healthcare System

location_facility: New Mexico Oncology Hematology Consultants, Ltd.

location_facility: Hospital Clínic i Provincial de Barcelona

location_facility: Republican Clinical Oncology Dispensary Kazan

location_facility: Moscow Scient. Res. Institute of Oncology n.a P.A. Hertzen

location_facility: Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopi

location_facility: CIUSSS de l'Estrie- Centre Haute-Yamaska

location_facility: Spitalul Clinic Judetean de Urgenta Oradea

location_facility: Clinical Hospital Center Bezanijska kosa

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital

location_facility: Kyungpook National University Chilgok Hospital

location_facility: Inst. de Assistência Médica ao Sérvidor Público Estadual

location_facility: P. Stradins Clinical University Hospital

location_facility: The Catholic University of Korea Seoul St. Mary's Hospital

location_facility: University College London Hospitals NHS Foundation Trust

location_facility: The First Affiliated Hospital of Wenzhou Medical University

location_facility: Medizinische Fakultät der Otto-von-Guericke Universität

location_facility: Uro-Gyn-Zentrum Wall Hr. Dr. Jochen Gleißner

location_facility: Fundación Oftalmológica de Santander Carlos Ardila Lule

location_facility: Androgeos - private center of urology and andrology

location_facility: Fundação Pio XII - Hospital de Câncer de Barretos

location_facility: Hospital Central de la Fuerza Aerea del Perú

location_facility: Centrum Onkologii - Instytut im. M.Sklodowskiej-Curie

location_facility: Health Corporation of the Ziv Medical Center (R.A.)

location_facility: Huadong Hospital, Affiliated to Fudan University

location_facility: Ciutat Sanitària i Universitària de Bellvitge

location_facility: Universitätsklinikum der Johann Wolfgang Goethe Universität

location_facility: The First Affiliated Hospital of Xiamen University

location_facility: G. Kenneth Jansz Medicine Professional Corporation

location_facility: Hospital de la Santa Creu i de Sant Pau | Oncología

location_facility: Institut Bergonié - Unicancer Nouvelle Aquitaine

location_facility: City Outpatient Clinic #1 of Privolzhsky Regional Med. Cent.

location_facility: City Dnipropetrovsk Multi- field Clinical Hosp. 4 DSMA

location_facility: Istituto Nazionale Tumori IRCCS Fondazione G.Pascale

location_facility: Hospital General Universitario Gregorio Marañón | Oncología

location_facility: Zuyderland Medisch Centrum Sittard-Geleen

location_facility: Centre Hospitalier Universitaire - Angers

location_facility: Instituto do Câncer do Estado de São Paulo

location_facility: Kingston Health Sciences Centre - Kingston General Hospital

location_facility: Clinical Oncological Dispensary of Omsk Region

location_facility: Keimyung University Dongsan Medical Center

location_facility: N.N. Alexandrov National Cancer Centre of Belarus

location_facility: Multi-Field Clinical Medical Center "Medical City"

location_facility: Pinderfields Hospital The Mid Yorkshire Hospitals NHS Trust

location_facility: Princess Margaret Hospital-University Health Network

location_facility: Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS

location_facility: Dept Radiation and Oncology Tygerberg Academic Hospital

location_facility: AS "Association of Health Centers" polyclinic "Elite"

location_facility: Szpital Grochowski im. dr.med. Rafala Masztaka

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre

location_facility: Chelyabinsk Regional Oncology Dispensary

location_facility: Centre d'Oncologie et de Radiologie du Parc

location_facility: Fundacion Jimenez Diaz (Clinica de la Concepcion)

location_facility: Hosp. Araujo Jorge da Associação de Combate ao Câncer

location_facility: Krasnoyarsk Regional Clinical Oncology Dispensary

location_facility: Institut de Cancérologie de l'Ouest - Saint Herblain

location_facility: Transkarpathian Regional Oncology Center

location_facility: Vilnius University Hospital Santaros Klinikos

location_facility: Urologische Gemeinschaftspraxis Dr. Simone Maier

location_facility: União Bras. de Edu. e Assist. Hospital São Lucas da PUCRS

location_facility: Instituto Peruano de Oncología & Radioterapia- Oncologia SAC

summary: The aim of this study is to provide darolutamide treatment to patients who participated in a previous study with darolutamide supported by Bayer and the treating doctor considers that the continuation of the treatment with darolutamide to be beneficial. Patients will be carried over from the previous studies and continue in this study with darolutamide treatment on the same dosage. They will also return to the study centers for doctor's visits as often as they did in the previous study.

lead_sponsor_type: industriel

status_simplified: Ongoing


ipd_sharing: Yes

primary_purpose: Treatment

intervention_type: Radiation

acronym: TrilynX

title: A Randomized, Double-Blind Placebo-Controlled, Phase 3 Study of Debio 1143 in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

lead_sponsor: EMD Serono Research & Development Institute, Inc.

type: Other Identifier

design_allocation: Randomized

ReferenceType: derived

ReferenceCitation: Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE. Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design. Future Oncol. 2022 May;18(14):1669-1678. doi: 10.2217/fon-2021-1634. Epub 2022 Feb 17. Review.

ipd_sharing_description: We are committed to enhancing public health through responsible sharing of clinical trial data. Following approval of a new product or a new indication for an approved product in both the US and European Union, the study sponsor and/or its affiliated companies will share study protocols, anonymized patient data and study level data, and redacted clinical study reports with qualified scientific and medical researchers, upon request, as necessary for conducting legitimate research. Further information on how to request data can be found on our website bit.ly/IPD21

location_country:
Spain
Italy
United Kingdom
Ukraine
United States
Belgium
Japan
Czechia
Poland
Portugal
Austria
Australia
Russian Federation
Argentina
Israel
Brazil
Canada
Switzerland
Hungary
China
Germany
Taiwan
Greece
Georgia
Korea, Republic of
France

location_facility: Instituto Medico Especialazado Alexander Fleming

location_facility: Pusan National University Yangsan Hospital, Oncol & Hematology

location_facility: Washington University School of Medicine

location_facility: University Hospital Southampton NHS Foundation Trust

location_facility: The 5th Affiliated Hospital of Sun yet-sen university

location_facility: Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP)

location_facility: Hospital Civil (Hospital Regional Universitario)

location_facility: Fondazione Policlinico Universitario Agostino Gemelli

location_facility: FGBU N.N.Blokhin Russian Cancer Research Center

location_facility: Institut de Cancérologie de l Ouest (ICO)

location_facility: Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie

location_facility: Mater Salutis Hospital AULSS 9 della Regione Venet

location_facility: National Hospital Organization Shikoku Cancer Center

location_facility: Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle

location_facility: Institut Català d'Oncologia, Hospital Duran

location_facility: Centre Hospitalier Universitaire Vaudois Lausanne

location_facility: CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie

location_facility: Princess Alexandra Hospital, Cancer Trials Unit

location_facility: Medical University of South Carolina- Hollings Cancer Center

location_facility: University of Oklahoma Health Sciences Center- Stephenson Cancer Center

location_facility: Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie

location_facility: Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital

location_facility: Kursk Regional Clinical Oncology Dispensary

location_facility: Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde

location_facility: Harbin Medical University Cancer Hospital

location_facility: IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO

location_facility: Institut Gustave Roussy - Service de radiotherapie

location_facility: Wake Forest University School of Medicine

location_facility: Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus

location_facility: State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital

location_facility: Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology

location_facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone Health

location_facility: Orszagos Onkologiai Intezet Sugarterapias Osztaly

location_facility: National Cancer Center Hematologic Oncology

location_facility: Centro Hospitalar de Vila Nova de Gaia/Espinho

location_facility: Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology)

location_facility: Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer

location_facility: Universitaetsklinikum Jena - Klinik fuer Hals - Nasen und Ohrenheilkunde HNO

location_facility: Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E

location_facility: State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS)

location_facility: Seoul National University Boramae Medical Center

location_facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University

location_facility: Research Fund of the Hadassah Medical Organization

location_facility: Clatterbridge Cancer Centre NHS Foundation Trust

location_facility: State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan"

location_facility: Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro"

location_facility: London Regional Cancer Program, London Health Sciences Centre

location_facility: Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach

location_facility: Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika

location_facility: Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia

location_facility: University Medical Center Schleswig-Holstein, Campus Kiel

location_facility: Petz Aladár Megyei Kórház Onkoradiológiai Osztály

location_facility: Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet

location_facility: Agioi Anargiroi General Oncology Hospital of Kifissia

location_facility: University Hospital Kyoto Prefectural University of Medicine

location_facility: Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii

location_facility: Centro Hospitalar Universitário Lisboa Norte

location_facility: Service d'Oncologie Médicale, CHU Timone

location_facility: Centro Hospitalar de Tras os Montes e Alto Douro (PRT)

location_facility: Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center

location_facility: Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro

location_facility: Centro Hospitalar Universitario São João

location_facility: Instituto de Investigaciones Medicas Alfredo Lanari - IDIM

location_facility: Tianjin Medical University Cancer Institute & Hospital

location_facility: Institut Universitari Dexeus-Quiron (ESP)

location_facility: The 2nd Affiliated Hospital of Zhejiang University School of Medicine

location_facility: Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela

location_facility: Affiliated Tumor Hospital of Guangxi Medical University

location_facility: Tongji Hospital/Tongji Medical College, Huazhong University of Science

location_facility: Hospital Universitario Insular de Gran Canaria

location_facility: LEPL First University Clinic of Tbilisi State Medical University

location_facility: Klinikum der Landeshauptstadt Stuttgart gKAöR

location_facility: Taipei Veterans General Hospital (VGHTP)

location_facility: The Oncology Institute of Hope & Innovation

location_facility: Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima

location_facility: Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT)

location_facility: Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer

location_facility: Saitama Medical University International Medical Center

location_facility: CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC

location_facility: Hospital de Caridade de Ijui, Avenida David Jose Martins

location_facility: Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie

location_facility: Universitätsklinik für Innere Medizin III der PMU

location_facility: Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie

location_facility: Medical center of Yuriy Spizhenko, Soborna Vulytsia

location_facility: Aberdeen Royal infirmary, Dept. of Oncology

location_facility: University of Colorado at Denver and Health Sciences Center

location_facility: Hospital Universitario Marqués de Valdecilla. Santander

location_facility: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

location_facility: Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine

location_facility: Republican Clinical Oncological Dispensary of Bashkortostan

location_facility: West China Hospital of Sichuan University

location_facility: FSBI National Med Research Cancer Center N.N. Petrov

location_facility: The Royal Marsden NHS Foundation Trust - Sutton

location_facility: Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro

location_facility: Department of radiation oncology, University Hospital Essen

location_facility: Seoul National University Bundang Hospital

location_facility: Kaohsiung Medical University Memorial Hospital

location_facility: Az. USL 6 Ospedali Riuniti-Ospedale di Livorno

location_facility: Instituto do Cancer do Estado de Sao Paulo (ICESP)

location_facility: CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont

location_facility: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center

location_facility: Institut de Cancérologie de l'Ouest - Site Saint Herblain

location_facility: Nottingham University Hospitals NHS Trust

location_facility: Azienda Ospedaliero Universitaria di Parma

location_facility: Institut Regional du Cancer de Montpellier

location_facility: UPMC Hillman Cancer Center - Clinical Research ServicesUSA)

location_facility: University Hospital Cleveland Medical Center

location_facility: Medical University of Vienna, Department of Medicine I, Division of Oncology

location_facility: Charité - Universitätsmedizin Berlin Campus Virchow

location_facility: Comprehensive Cancer Center of Nevada (Southern Hills) (USA)

location_facility: Xiangya Hospital Central South University

location_facility: IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

location_facility: NYU Langone Hospital-Long Island Oncology

location_facility: The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC)

location_facility: Centre hospitalier Universitaire de Bordeaux

location_facility: Ashford Cancer Centre Research, Tennyson Centre

location_facility: Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale"

location_facility: Northern Alberta Clinical Trials & Research Centre (NACTRC)

location_facility: The Public Hospital L'Institut de Cancerologie de Lorraine

location_facility: Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky

location_facility: University of Missouri - Ellis Fischel Cancer Center

location_facility: Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE

summary: The primary objective of the study is to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).


title: A Reduced Dose of Thrombolytic Treatment for Patients With Intermediate High-risk Acute Pulmonary Embolism: a Randomized Controled Trial

lead_sponsor: Assistance Publique - Hôpitaux de Paris

type: Other Grant/Funding Number

ReferenceType: background

ReferenceCitation: Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galiè N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV; PEITHO Investigators. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014 Apr 10;370(15):1402-11. doi: 10.1056/NEJMoa1302097.

ReferenceCitation: Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV; PEITHO Investigators. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J. 2018 Jan 18;51(1). pii: 1701775. doi: 10.1183/13993003.01775-2017. Print 2018 Jan.

ReferenceCitation: Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G. Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. J Am Coll Cardiol. 2017 Mar 28;69(12):1536-1544. doi: 10.1016/j.jacc.2016.12.039.

ReferenceCitation: Marti C, John G, Konstantinides S, Combescure C, Sanchez O, Lankeit M, Meyer G, Perrier A. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J. 2015 Mar 7;36(10):605-14. doi: 10.1093/eurheartj/ehu218. Epub 2014 Jun 10. Review.

ReferenceCitation: Sanchez O, Charles-Nelson A, Ageno W, Barco S, Binder H, Chatellier G, Duerschmied D, Empen K, Ferreira M, Girard P, Huisman MV, Jiménez D, Katsahian S, Kozak M, Lankeit M, Meneveau N, Pruszczyk P, Petris A, Righini M, Rosenkranz S, Schellong S, Stefanovic B, Verhamme P, de Wit K, Vicaut E, Zirlik A, Konstantinides SV, Meyer G; PEITHO-3 Investigators. Reduced-Dose Intravenous Thrombolysis for Acute Intermediate-High-risk Pulmonary Embolism: Rationale and Design of the Pulmonary Embolism International THrOmbolysis (PEITHO)-3 trial. Thromb Haemost. 2022 May;122(5):857-866. doi: 10.1055/a-1653-4699. Epub 2021 Oct 31.

ipd_sharing_description: Individual participant data (IPD) that underlie results in publication could be shared. IPD detailed in the protocol of a planned metaanalysis could be shared.

location_country: Poland Portugal Romania Serbia Italy Austria Netherlands Slovenia Canada Spain Switzerland France Belgium Germany

location_facility: University Hospital Ancona / Ospedali Riunit

location_facility: Bucuresti - Spitalul Clinic de Urgenta Sf. Pantelimon

location_facility: Hannover, Medizinische Hochschule Hannover

location_facility: Institutul de Boli Cardio-Vasculare Timisoara

location_facility: Cardiology Clinic, Emergency Center, Clinical Center of Serbia

location_facility: Department of Cardiac and Vascular Diseases

location_facility: CHU de Brest - Hôpital de la Cavale Blanche

location_facility: Institute for Lung Diseases of Vojvodina, Sremska Kamenica

location_facility: AP-HP - hôpital européen Georges-Pompidou

location_facility: Centro Hospitalar de Lisboa Norte/ Hospitalde Santa Maria

location_facility: Cardiology Clinic, Clinical Center of Niš

location_facility: The Ottawa Hopsital, General and Civic campuses

location_facility: Iasi - St Spiridon Emergency Conty Hospital

location_facility: CHU de Clermont-Ferrand - Hôpital Gabriel Montpied

summary: In this study, we will assess the efficacy and safety of a reduced dose of thrombolytic therapy given in addition to low-molecular-weight heparin in patients with intermediate-high-risk acute pulmonary embolism. Half of participants will receive thrombolytic treatment, while the other half will receive a placebo.

lead_sponsor_type: academique


title: A Randomized, Double-blind, Placebo-Controlled, Active-Comparator, Multicenter, Phase 3 Study of Brentuximab Vedotin or Placebo in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

summary:
Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone.

Participants will be randomly assigned to get either brentuximab vedotin or placebo. The placebo will look like brentuximab vedotin, but has no medicine in it. Since the study is "blinded," participants and their doctors will not know whether a participant gets brentuximab vedotin or placebo. All participants in the study will get rituximab and lenalidomide. These are drugs that can be used to treat DLBCL.

ReferenceCitation: Ward JP, Berrien-Elliott MM, Gomez F, Luo J, Becker-Hapak M, Cashen AF, Wagner-Johnston ND, Maddocks K, Mosior M, Foster M, Krysiak K, Schmidt A, Skidmore ZL, Desai S, Watkins MP, Fischer A, Griffith M, Griffith OL, Fehniger TA, Bartlett NL. Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma. Blood. 2022 Mar 31;139(13):1999-2010. doi: 10.1182/blood.2021011894.

lead_sponsor: Seagen Inc.

location_country:
Denmark
Poland
Taiwan
Spain
Italy
United Kingdom
Australia
Canada
Switzerland
Korea, Republic of
United States
France
Belgium
Germany
Czechia

location_facility: Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer

location_facility: University of Ottawa / Ottawa General Hospital

location_facility: Azienda Ospedaliero-Universitaria di Bologna - IRCCS

location_facility: Hospital Universitario Quironsalud Madrid

location_facility: The Oncology Institute of Hope & Innovation - California

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: Chang Gung Memorial Hospital - Kaohsiung

location_facility: Soon Chun Hyang University Hospital Seoul

location_facility: Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital Morvan

location_facility: Centre Hospitalier Universitaire (CHU) Dijon Bourgogne

location_facility: Centre de Lutte Contre le Cancer (CLCC) - Institut Bergonie

location_facility: Universita degli Studi di Perugia Azienda Ospedaliera di Perugia (Ospedale Santa Maria della Misericordia)

location_facility: Illinois Cancer Specialists / Advocate Lutheran General Hospital

location_facility: Willamette Valley Cancer Institute and Research Center

location_facility: Cancer and Hematology Centers of Western Michigan / Lemmen-Holton Cancer Pavilion

location_facility: Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes

location_facility: Saint Francis Hospital / Bon Secours - South Carolina

location_facility: Queen Elizabeth II Health Sciences Centre

location_facility: Hospital Regional Universitario de Málaga - Hospital General

location_facility: Centre Hospitalier Universitaire de Grenoble

location_facility: St. Vincent's Hospital, The Catholic University of Korea

location_facility: Florida Cancer Specialists - South Region

location_facility: Azienda Ospedaliera Cardinale Giovanni Panico

location_facility: Centre Hospitalier Metropole Savoie - Chambery

location_facility: Zealand University Hospital (Roskilde Sygehus)

location_facility: Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie

location_facility: Karmanos Cancer Institute / Wayne State University

location_facility: Texas Oncology - San Antonio Medical Center

location_facility: Centre Hospitalier Universitaire de Nancy - Hopital de Brabois

location_facility: CIUSSS de L'Est de l'lle de Montreal / installation Hopital Maisonneuve-Rosemont

location_facility: Centre Hospitalier Universitaire Nantes-Hotel Dieu

location_facility: Hospital Clínico Universitario de Salamanca

location_facility: Severance Hospital, Yonsei University Health System

location_facility: IRCCS Ospedale Casa Sollievo della Sofferenza

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: Azienda Ospedaliero Universitaria Careggi

location_facility: Medical University of South Carolina/Hollings Cancer Center

location_facility: Florida Cancer Specialists - East West Palm Beach, FL (SCRI)

location_facility: H. Bliss Murphy Cancer Centre / Eastern Regional Health Authority

location_facility: Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne

location_facility: CIUSS NIM/Hopital du Sacre-Coeur de Montreal

location_facility: Institut de Cancerologie Hematologie Universitaire de Saint Etienne (I.CHU.SE)

location_facility: Keimyung University Dongsan Medical Center

location_facility: Ziekenhuis Netwerk Antwerpen Campus Stuivenberg

location_facility: Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)

location_facility: Azienda Ospedaliera Universitaria (AOU) Federico II

location_facility: Azienda Sanitaria Universitaria Giuliano Isontina

location_facility: MD Anderson Cancer Center at Cooper Health

location_facility: Center Hospitalier Universitaire d' Angers

location_facility: London Health Sciences Centre - Victoria Hospital

location_facility: University of Cincinnati Cancer Institute

location_facility: Florida Cancer Specialists - North Region

location_facility: Hospital Universitario Central de Asturias

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren

location_facility: Central Coast Local Health District (Gosford and Wyong Hospitals)

location_facility: Carbone Cancer Center / University of Wisconsin

location_facility: Centre Hospitalier Regional Metz-Thionville, Hopital Mercy

location_facility: CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies

intervention_type: Other


status: Active, not recruiting

acronym: TIRHOL

title: A Phase 2, Multicenter, Open-Label Study of Tislelizumab (BGB-A317) in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma

lead_sponsor: BeiGene

design_allocation: Non-Randomized

enrollment_type: Actual

location_country:
Australia
Puerto Rico
United States
France
Belgium

location_facility: CHU de Liège - Domaine Universitaire du Sart Tilman

location_facility: Institut Gustave Roussy- Cancer Campus Grand Paris

location_facility: Huntsman Cancer Center, University of Utah

location_facility: Institut d'Hematologie de Basse-Normandie

summary: The primary objective of the study is to evaluate the efficacy of tislelizumab in participants with relapsed/refractory classical Hodgkin lymphoma, as measured by the overall response rate per the Lugano Classification, and as determined by the investigator.


title: A Phase 3 Multicenter, Randomized, Open Label, Active-controlled, Study of AMG 510 Versus Docetaxel for the Treatment of Previously Treated Locally Advanced and Unresectable or Metastatic NSCLC Subjects With Mutated KRAS p.G12C

lead_sponsor: Amgen

ipd_sharing_description: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Japan
Poland
Portugal
Russian Federation
Australia
Sweden
Brazil
Canada
Switzerland
Hungary
Germany
Denmark
Taiwan
Greece
Finland
Korea, Republic of
France
Netherlands

location_facility: The Center for Cancer and Blood Disorders

location_facility: Hospital Universitario Puerta de Hierro Majadahonda

location_facility: Instituto Catalan de Oncologia Hospital Duran i Reynals

location_facility: United States Oncology Regulatory Affairs Corporate Office

location_facility: University of California San Francisco Mission Hall

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

location_facility: Policlinico Universitario Agostino Gemelli

location_facility: National Hospital Organization Shikoku Cancer Center

location_facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

location_facility: Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

location_facility: Hospital of the University of Occupational and Environmental Health

location_facility: Centre Hospitalier Universitaire de Limoges - Hopital Dupuytren

location_facility: Montefiore Einstein Center for Cancer Care

location_facility: Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati

location_facility: Fundacao Antonio Prudente - Hospital A C Camargo

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Centre Hospitalier de Nantes - HÃ´pital Nord LaÃ"nnec

location_facility: Studiengesellschaft HÃ¤mato Onkologie Hamburg Prof Laack und Partner

location_facility: Centrum Onkologii Instytut im Marii Sklodowskiej-Curie

location_facility: Fort Wayne Medical Oncology and Hematology

location_facility: Saint Petersburg scientifical practical center of specialized kinds of medical care oncological

location_facility: Northwest Cancer Specialists - Vancouver

location_facility: Kobe City Medical Center General Hospital

location_facility: Universite Catholique de Louvain Cliniques Universitaires Saint Luc

location_facility: Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz

location_facility: Azienda Ospedaliera Policlinico Umberto I

location_facility: Hospital Clinic i Provincial de Barcelona

location_facility: Nederlands Kanker Instituut Antoni van Leeuwenhoekziekenhuis

location_facility: Centre Hospitalier Universitaire RÃ©gional de Lille - HÃ´pital Albert Calmette

location_facility: Sociedade Beneficente de Senhoras Hospital Sirio Libanes

location_facility: National Hospital Organization Iwakuni Clinical Center

location_facility: Azienda Ospedaliera Universitaria San Luigi Gonzaga

location_facility: Clinical hospital 2, Group of companies medsi

location_facility: University of California at Davis Medical Center

location_facility: Dolnoslaskie Centrum Onkologii we Wroclawiu

location_facility: Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque

location_facility: Instytut Genetyki i Immunologii GENIM Spzoo

location_facility: Hospital de Base de Sao Jose do Rio Preto

location_facility: Harbor University of California Los Angeles Medical Center

location_facility: Florida Cancer Specialists Research North

location_facility: Euromedica General Clinic of Thessaloniki

location_facility: Cancer Institute Hospital of Japanese Foundation for Cancer Research

location_facility: Omsk Regional Clinical Oncology Dispensary

location_facility: Asklepios - Fachkliniken MÃ¼nchen-Gauting

location_facility: Hospital Universitario Insular de Gran Canaria

location_facility: Chugoku Central Hospital of Japan Mutual Aid Association of Public School Teachers

location_facility: Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: The Catholic University of Korea Seoul St Marys Hospital

location_facility: National Hospital Organization Yamaguchi Ube Medical Center

location_facility: University of Texas MD Anderson Cancer Center

location_facility: Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula

location_facility: Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust

location_facility: National Hospital Organization Kinki-chuo Chest Medical Center

location_facility: Azienda Ospedaliero Universitaria Careggi

location_facility: Shiga University of Medical Science Hospital

location_facility: Centro Hospitalar Universitario do Porto EPE - Hospital de Santo Antonio

location_facility: Centro Hospitalar Universitario de Sao Joao EPE - Hospital Sao Joao

location_facility: Centre Hospitalier Universitaire de Liege

location_facility: Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon

location_facility: US Oncology Research Investigational Products Center

location_facility: Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: Cha Bundang Medical Center, Cha University

location_facility: Complexo Hospitalario Universitario A CoruÃ±a Hospital Teresa Herrera

location_facility: Centre Hospitalier de L'Universite de Montreal Hopital Notre-Dame

location_facility: General Oncology Hospital of Kifissia Agioi Anargyroi

location_facility: Azienda UnitÃ Sanitaria Locale della Romagna Presidio ospedaliero di Ravenna

location_facility: Centre Hospitalier Universitaire de Toulouse - Hopital Larrey

location_facility: Algemeen Ziekenhuis Nikolaas Campus Sint Niklaas

location_facility: Azienda Ospedaliera Universitaria di Bologna Policlinico S Orsola Malpighi

location_facility: Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE

location_facility: Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Presidio Ospedaliero G Rodolico

location_facility: Seoul National University Bundang Hospital

location_facility: Centre Hospitalier Intercommunal de CrÃ©teil

location_facility: Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im K Marcinkowskiego w Poznaniu

location_facility: Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

location_facility: Hospital Regional Universitario de Malaga

location_facility: Medical Oncology Hematology Consultants Helen F Graham Cancer Center

location_facility: Florida Cancer Specialists Research Panhandle

location_facility: Centro de Tratamento de Tumores Botafogo

location_facility: Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil

location_facility: FSBI Scientific and Research Oncology Institute named after N N Petrov

location_facility: National Hospital Organization Hokkaido Cancer Center

location_facility: Severance Hospital Yonsei University Health System

location_facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg

location_facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: Centro Hospitalar Universitario de Lisboa Norte EPE - Hospital Pulido Valente

location_facility: Centre Hospitalier Regional Universitaire - Hopital Morvan

location_facility: Washington Cancer Institute at MedStar Washington Hospital

location_facility: Charite UniversitÃ¤tsmedizin Berlin, CharitÃ© Campus Virchow-Klinikum

location_facility: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

location_facility: St Marianna University School of Medicine Hospital

location_facility: Azienda Socio Sanitaria Territoriale di Monza Ospedale San Gerardo

location_facility: National Hospital Organization Himeji Medical Center

summary: A Phase 3 Study to Compare AMG 510 with Docetaxel in Non Small Cell Lung Cancer (NSCLC) subjects with KRAS p. G12c mutation


title: Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe - a MultInatioNal ObservatIonal Study (SANTORINI)

acronym: SANTORINI

summary: High and Very High Risk cardiovascular patient journeys seems to vary from country to country, and current understanding of the process is incomplete. This real-life observational study which documents meaningful patient journey-related parameters can be expected to provide meaningful insight into the care process, country-by-country.

study_type: Observational

time_perspective: Other

ipd_sharing_description: De-identified individual participant data (IPD) and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/

lead_sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

location_country:
Denmark
Portugal
Spain
Ireland
Austria
Italy
Netherlands
Finland
United Kingdom
Switzerland
Sweden
France
Belgium
Germany

location_facility: Liverpool Heart & Chest Hospital NHS Trust

location_facility: ASL Roma 6 - Ospedali Riuniti Anzio - Nettuno

location_facility: Gemeinschaftspraxis Drs. Haggenmiller/Jeserich Kardiologie-Angiologie-Innere Medizin

location_facility: Hospital de Alta Resolución de Sierra Norte

location_facility: Sastamalan seudun sosiaali- ja terveyspalvelut

location_facility: Kardiologische Praxis Papenburg (Site 6098)

location_facility: Hospital Universitario Virgen de la Macarena

location_facility: Azienda Ospedaliera Universitaria Mater Domini - Site 8059

location_facility: Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet

location_facility: A.O.U. Consorziale - Policlinico Bari (Dipartimento di Medicina Interna)

location_facility: Gemeinschaftspraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte

location_facility: Ordination Universitätsdozent Dr. Alexander Kober

location_facility: Ordination Dr. Thomas Maca / Evangelische KH Wien

location_facility: Praxis für Innere Medizin / Kardiologie - Dr. med. E. Persicke / Dr. med. O. Scheuermann

location_facility: Ospedali Riuniti "Umberto I - Lancisi - Salesi

location_facility: Ospedale SS Cosma e Damiano di Pescia - Azienda Usl Toscana centro

location_facility: Östra Sahlgrenska Universitetssjukhuset - Ostra Sjukhuse

location_facility: Hospital de Sant Joan Despí Moisès Broggi

location_facility: Ospedale Civile Santa Maria Incoronata dell'Olmo

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (U.O Medicina Generale 2)

location_facility: MVZ Dres. Ramdohr - Praxis für Cardiovascular und Ultraschalldiagnostik

location_facility: Kardiologie Oberschwaben - Bodensee Herz- und Gefäßpraxis

location_facility: Presidio ospedaliero Cardinal Massaia - A.S.L. AT (SOC Diabetologia e Malattie Metaboliche)

location_facility: Arcispedale Sant'Anna Ferrara (U.O. Cardiologia)

location_facility: Ente Ecclesiastico Ospedale Generale Regionale "F.Miulli"

location_facility: Praxis Dipl. - Med. Petra Herrmann - Fachärztin für Innere Medizin

location_facility: Azienda Ospedaliera Universitaria Mater Domini - Site 8053

location_facility: Policlinico Sant'Orsola-Malpighi (U.O. Cardiologia)

location_facility: Centro Hospitalar Universitario do Algarve

location_facility: Complejo Hospitalario Universitario A Coruña

location_facility: Azienda Ospedaliera di Rilievo Nazionale(A.O.R.N.) "Sant'Anna e San Sebastiano" di Caserta

location_facility: Arcispedale Santa Maria Nuova - Azienda USL/IRCCS Reggio Emilia

location_facility: Centre Hospitalier de Lisieux, 4 Rue Roger Aini

location_facility: Centro Cardiologico Monzino - IRCCS (Unità Prevenzione dell'Aterosclerosi)

location_facility: Centro Hospitalar Lisboa Norte - Site 10006

location_facility: Hospital Universitario de la Princesa Site 11062

location_facility: Centre Hospitalier Universitaire de Nantes

location_facility: Kardiologie im Friedrichspalast Bruchsal

location_facility: Ospedale Santo Stefano di Prato - Azienda Usl Toscana Centro

location_facility: A.O.U di Bologna-Policlinico S.Orsola-Malpighi (U.O. Medicina Interna)

location_facility: Kobenhavns Universitet - Holbaek Sygehus

location_facility: Rigshospitalet (Copenhagen University Hospital) - Glostrup (Glostrup Hospital)

location_facility: B. Braun Ambulantes Herzzentrum MVZ GmbH

location_facility: Ospedale S. Andrea - Usl Toscana Sud Est

location_facility: A.O.U. Policlinico "G. Martino" (U.O. Cardiologia)

location_facility: A.O.U. Careggi (S.O.D. Malattie Aterotrombotiche) - Site 8020

location_facility: Internistische Facharztpraxis Frau Dr. Carmen Gelsinger

location_facility: Konventhospital der Barmherzigen Brüder Linz

location_facility: Grande Ospedale Metropolitano di Niguarda

location_facility: A.O.U. FEDERICO II (U.O.C. Diabetologia)

location_facility: Praxis für Herzkreislauferkrankungen Greiz

location_facility: Azienda Ospedaliero-Universitaria Senese Dipartimento Delle Scienze Mediche U.O.C. Medicina Interna e della Complessità

location_facility: Kardiologische Gemeinschaftspraxis Dres. Wetzel/Willgeroth

location_facility: Centro Hospitalar Universitário São João (CHUSJ)

location_facility: Azienda Ospedaliera-Universitaria S. Anna di Ferrara (Dipartimento medico)

location_facility: A.O. San Giuseppe Moscati (U.O.C. Cardiologia/UTIC)

location_facility: Studienzentrum der Inneren Medizin I & II am Klinikum Konstanz

location_facility: Azienda Ospedaliera San Giovanni Addolorata

location_facility: Ospedale Civile SS Annunziata (Dipartimento di Medicina Clinica e Sperimentale)

location_facility: Zentrum für klinische Prüfungen in der Facharztzentrum Dresden-Neustadt GbR

location_facility: Fondazione Policlinico Universitario A. Gemelli IRCCS

location_facility: A.O.U. Città della Salute e della Scienza di Torino

location_facility: Karolinska University Hospital, Huddinge

location_facility: Ropcke Zweers hospital, Jan Weitkamplaan 4-a

location_facility: Ospedale di Bolzano (U.O. Cardiologia e Prove Funzionali)

location_facility: Hospital Universitario de la Princesa Site 11054

location_facility: Hausärztlich-Kardiologisches MVZ "Am Felsenkeller" GmbH

location_facility: Presidio Ospedaliero "Santa Maria della Misericordia" di Udine

location_facility: Krankenhaus Hietzing mit neurologischem Zentrum Rosenhügel

location_facility: MVZ Prof. Detlef Mathey, Prof. Schofer GmbH

location_facility: Azienda Ospedaliera Universitaria Mater Domini - Site 8042

location_facility: Kliniken an der Paar - Krankenhaus Aichach

location_facility: Ospedale Cisanello - A.U.O.P. Azienda Ospedaliera Universitaria Pisana

location_facility: Kardiologische Facharztpraxis Dr. Anne Winkelmann

location_facility: Gemeinschaftspraxis Dres. J. Hintze und M. Grundner

location_facility: Centre Hopsitalier Alpes Leman, 552 Route de Findrol

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico

location_facility: Associação Protetora de Diabéticos de Portugal

location_facility: Complejo Hospitalario Universitario de Ourense (CHOU) Site 11052

location_facility: Centro Hospitalar Lisboa Norte - Site 10005

location_facility: Institut Cœur Poumons, Boulevard du Pr Leclercq

location_facility: Ospedale Civile SS. Annunziata (MEDICINA INTERNA- DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO)

location_facility: Praxis für Gefäßerkrankungen und Gerinnungsstörungen Leipzig

location_facility: Complejo Hospitalario Universitario de Ourense (CHOU) Site 11003

location_facility: Centro Hospitalar de Entre Douro e Vouga

location_facility: Herzquartier Mühlheim, Kardiologische Gemeinschaftspraxis Dres. med. A. Krapivsky & P. Kekes

location_facility: Ospedale Civile di Baggiovara- AOU di Modena

location_facility: Fondazione Poliambulanza Istituto Ospedaliero - Brescia

location_facility: Presidio Ospedaliero di Mirano - ULSS 3 Serenissima

location_facility: Zentrum für Klinische Studien Dr. Hanusch GmbH

location_facility: A.O.U. "San Giovanni di Dio e Ruggi d'Aragona"

location_facility: Centre de Cardiologie et d'exploration de la Côte Basque

location_facility: Zentrum für Diabetes und Gefäßerkrankungen Münster

location_facility: Ordination Dr. med. univ. Evelyn Fließer-Görzer

location_facility: Ijsselland Ziekenhuis, Prins Constanijnweg 2

location_facility: Ospedale di Santo Stefano di Prato - Azienda Usl Toscana centro (UO di Cardiologia)

location_facility: Ordination Dr. Thomas Maca / Evangelisches KH Wien

location_facility: Gemeinschaftspraxis Dr. Täschner/Dr. Bonigut

location_facility: Zentrum für Prävention und Rehabilitation

location_facility: Hospital Universitario de la Princesa Site 11075

location_facility: Praxis für Innere Medizin und Angiologie

location_facility: Kardiologische Praxis Papenburg (Site 6097)

location_facility: Krankenhaus der Barmherzigen Brüder Trier

location_facility: Policlinico Universitario Campus Bio-Medico

location_facility: Hospital Universitario Fundación Alcorcón


title: A Multicenter, Double-blind, Randomized Withdrawal Extension Study of Subcutaneous Secukinumab to Demonstrate Long-term Efficacy, Safety and Tolerability in Subjects With Moderate to Severe Hidradenitis Suppurativa

summary: The purpose of this extension study is to evaluate maintenance of HiSCR response at Week 104 in either continuous or interrupted therapy (using a randomized withdrawal period) of two dose regimens and to assess long-term efficacy, safety and tolerability of secukinumab in subjects with moderate to severe hidradenitis suppurativa completing either of the 2 Phase III studies. This is an expanded access trial for the core trials AIN457M2301 (NCT03713619) and AIN457M2302 (NCT03713619).

ipd_sharing: Undecided

ipd_sharing_description:
Novartis is committed to sharing access to patient-level data and supporting clinical documents from eligible studies with qualified external researchers. Requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to protect the privacy of patients who have participated in the trial in line with applicable laws and regulations.

This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com

lead_sponsor: Novartis Pharmaceuticals

location_country:
Croatia
Spain
Italy
United Kingdom
Lithuania
United States
Belgium
Japan
Philippines
South Africa
Czechia
Poland
Portugal
Austria
Australia
Russian Federation
Argentina
India
Israel
Turkey
Mexico
Malaysia
Singapore
Slovakia
Lebanon
Canada
Switzerland
Guatemala
Hungary
Germany
Bulgaria
Taiwan
Greece
Vietnam
Korea, Republic of
France
Colombia
Netherlands


title: Observational Study on Inappropriate Therapies After Replacement of ICDs

acronym: OSIRIS

summary: The purpose of the study is to assess the incidence of inappropriate shocks at 2 years, in a population of patients undergoing a generator replacement (VR/DR/CRT) or upgrade from a previously implanted ICD (VR/DR)

time_perspective: Prospective

ipd_sharing_description: A clinical study report will be completed at the end of the study and publication of study results may be performed

lead_sponsor: MicroPort CRM

location_country:
Portugal
Spain
Italy
Austria
Netherlands
United Kingdom
Switzerland
United States
France
Belgium
Germany

location_facility: Hospital Universitario Virgen de las Nieves

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Di Trieste

location_facility: Hospital General Universitario de Valencia

location_facility: Hospital General Universitario de Alicante

location_facility: Centro Hospitalar Lisboa Norte - Hospital de Santa Maria

location_facility: The University of Chicago Medicine Hospital

location_facility: Universitätsklinik Innsbruck - Kardiologie und Angiologie

location_facility: Grande Ospedale Metropolitano Niguarda Ca Granda

location_facility: Hospital Universitario Virgen de la Victoria

location_facility: Complejo Hospitalario Universitario de Vigo

intervention_type: Device


acronym: CheckMate 7DX

intervention_type: Biological

title: A Phase 3, Randomized, Double-Blind Study of Nivolumab or Placebo in Combination With Docetaxel, in Men With Metastatic Castration-resistant Prostate Cancer

lead_sponsor: Bristol-Myers Squibb

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Japan
Romania
Czechia
Poland
Hong Kong
Austria
Australia
Russian Federation
Argentina
Puerto Rico
Israel
Turkey
Mexico
Singapore
Brazil
Canada
China
Germany
Taiwan
New Zealand
Korea, Republic of
France
Chile

location_facility: P.A. Herzen Moscow Oncology Research Institute

location_facility: SAHI Republican Clinical Oncology Dispensary of MoH of RT

location_facility: Federal State Budgetary Institution N.N. Blokhin National Medical Research Center of Oncology of the

location_facility: GU Research Network/Urology Cancer Center

location_facility: Desert Hematology Oncology Medical Group Inc. - Main Office

location_facility: Englander Institute Weill Cornell Medicine

location_facility: Torrance Health Association DBA Cancer Care Associates

location_facility: Russian Scientific Centre of Radiology and Surgical Technologies n.a. acad. M.A.

location_facility: University of Maryland Greenebaum Cancer Center

location_facility: Pan American Center for Oncology Trials, LLC

location_facility: FSBI National Medical Research Radiology Center NMRRC - A. Tsyb Medical Radiological Research Centre

location_facility: University of Texas MD Anderson Cancer Clinic

location_facility: Charleston Hematology Oncology Associates CHOA

location_facility: The University of Texas Health Science Center at Tyler DBA UT Health East Texas Hope Cancer Center

location_facility: SBHI Arkhangelsk Region - Arkhangelsk Clinical Oncological Dispensary

location_facility: Institut Catala D 39 Oncologia Duran I Reynals

location_facility: Budgetary Healthcare Institution of Omsk Region &quot,Clinical Oncological Dispensary&quot,

location_facility: Clinical Research Center Spolka z ograniczona odpowiedzialnoscia Medic-R Sp.k.

location_facility: Orlando Health Inc., UF Health Cancer Center

summary: The purpose of this study is to assess the safety and effectiveness of nivolumab with docetaxel in men with advanced castration resistant prostate cancer who have progressed after second-generation hormonal manipulation.


title: A Phase 3b, Open-label, Single-arm, Rollover Study to Evaluate Long-term Safety in Subjects Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

lead_sponsor: Celgene

type: Registry Identifier

ipd_sharing_description:
BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria.

Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at: https://www.bms.com/researchers-and-partners/clinical-trials-and-research/disclosurecommitment.html

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Japan
Australia
Tunisia
Israel
Turkey
Sweden
Malaysia
Lebanon
Canada
Germany
Bulgaria
Taiwan
Greece
Thailand
France
Netherlands

location_facility: Ente Ospedaliero Ospedali Galliera - Centro della Microcitemia e delle Anemie Congenite

location_facility: AOU dell'Università degli Studi della Campania Luigi Vanvitelli

location_facility: Istanbul University Cerrahpasa Medical Faculty Hospital

location_facility: Ege Universitesi Tip Fakultesi Hastanesi

location_facility: Universitatsklinikum Carl Gustav Carus an der TU Dresden

location_facility: Azienda Ospedaliera Universitaria Careggi

location_facility: Centre Hospitalier Universitaire de Grenoble Hopital Albert Michallon

location_facility: Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola Malpighi

location_facility: Oxford University Hospitals NHS Foundation Trust-Churchill Hospital-Cancer and Haematology Centre

location_facility: General Hospital of Thessaloniki Hippokration

location_facility: The Leeds Teaching Hospitals NHS Trust - St James's University Hospital

location_facility: Ankara University Medical Faculty Cebeci Hospital

location_facility: Azienda Ospedaliera Santi Antonio Biagio E Cesare Arrigo

location_facility: Azienda Ospedaliera Bianchi Melacrino Morelli

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: Hospital of the University of Pennsylvania

location_facility: University College London Hospitals NHS Foundation Trust - University College Hospital

location_facility: Institut Universitaire du Cancer de Toulouse - Oncopole

location_facility: Ann & Robert H Lurie Children's Hospital of Chicago

location_facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

location_facility: Universitario de Salamanca - Hospital Clinico

location_facility: Multiprofile Hospital for Active Treatment Sveta Marina EAD

location_facility: Azienda Sanitaria Locale (ASL) Cagliari - Ospedale Regionale per le Microcitemie

location_facility: University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

location_facility: Maggiore Polyclinic Hospital, IRCCS Ca' Granda

location_facility: Karolinska Universitetssjukhuset - Huddinge

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: Medizinisches Versorgungszentrum (MVZ) Onkologischer Schwerpunkt am Oskar-Helene-Heim

location_facility: General Hospital Georgios Gennimatas of Athens

location_facility: Klinikum rechts der Isar der Technischen Universitaet Muenchen

location_facility: Aghia Sophia' Children's General Hospital of Athens

location_facility: Instituto Catalan de Oncologia-Hospital Duran i Reynals

location_facility: Chiang Mai University - Maharaj Nakorn Chiang Mai Hospital

location_facility: Vrije Universiteit Medisch Centrum (VUMC)

location_facility: UCSF Benioff Children's Hospital Oakland

location_facility: Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna

location_facility: Specialized Hospital for Active Treatment of Haematological Diseases - Sofia

location_facility: Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi

location_facility: Hospital Universitario Central de Asturias

location_facility: Laiko General Hospital of Athens - Center of Thalassemia

location_facility: Chulalongkorn University Faculty of Medicine - King Chulalongkorn Memorial Hospital

location_facility: Azienda Ospedaliero Universitaria S. Luigi Gonzaga

location_facility: Azienda Ospedaliera Universitaria Integrata Di Verona

location_facility: The University of Texas - MD Anderson Cancer Center

location_facility: Barts Health NHS Trust - The Royal London Hospital

location_facility: Azienda Ospedaliero Universitaria Di Modena Policlinico

summary:
A Phase 3b, open-label, single-arm, rollover study to evaluate the long-term safety of luspatercept, to the following participants:

Participants receiving luspatercept on a parent protocol at the time of their transition to the rollover study, who tolerate the protocol-prescribed regimen in the parent trial and, in the opinion of the investigator, may derive clinical benefit from continuing treatment with luspatercept
Participants in the follow-up phase previously treated with luspatercept or placebo in the parent protocol will continue into long-term post-treatment follow-up in the rollover study until the follow-up commitments are met
The study design is divided into the Transition Phase, Treatment Phase and Follow-up Phase. Participants will enter transition phase and depending on their background will enter either the treatment phase or the Long-term Post-treatment Follow-up (LTPTFU) phase
Transition Phase is defined as one Enrollment visit
Treatment Phase: For participants in luspatercept treatment the dose and schedule of luspatercept in this study will be the same as the last dose and schedule in the parent luspatercept study. This does not apply to participants that are in long-term follow-up from the parent protocol

Follow-up Phase includes:

- 42 Day Safety Follow-up Visit

During the Safety Follow up, the participants will be followed for 42 days after the last dose of luspatercept, for the assessment of safety-related parameters and adverse event (AE) reporting

- Long-term Post-treatment Follow-up (LTPTFU) Phase

Participants will be followed for overall survival every 6 months for at least 5 years from first dose of luspatercept in the parent protocol, or 3 years of post-treatment from last dose, whichever occurs later, or until death, withdrawal of consent, study termination, or until a subject is lost to follow-up. Participants will also be monitored for progression to AML or any malignancies/pre-malignancies. New anticancer or disease related therapies should be collected at the same time schedule

Participants transitioning from a parent luspatercept study in post-treatment follow-up (safety or LTPTFU) will continue from the same equivalent point in this rollover study.

The rollover study will be terminated, and relevant participants will discontinue from the study when all participants fulfill at least 5 years from the first dose of luspatercept in the parent protocol, or 3 years of post-treatment from last dose, whichever occurs later.


acronym: ASTONISH

title: Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock. A Randomized, Double-blind, Placebo Controlled Dose Selection Study

lead_sponsor: Inotrem

ReferenceCitation: Francois B, Lambden S, Gibot S, Derive M, Olivier A, Cuvier V, Witte S, Grouin JM, Garaud JJ, Salcedo-Magguilli M, Levy M, Laterre PF. Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial. BMJ Open. 2021 Jul 7;11(7):e042921. doi: 10.1136/bmjopen-2020-042921.

location_country: Denmark Spain Ireland Finland France Belgium

location_facility: Hospital Universitario y Politecnico la Fe

location_facility: Helsinki University Hospital Adult ICU PPDS

location_facility: Hôpital d'instruction des Armées Robert Picqué

location_facility: Hospital universitario DR. Peset Aleixandre

location_facility: Hospital Universitario Dentral de Asturias

summary:
This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo.

All patients with a diagnosis of septic shock will be considered for study participation. All potential study patients will receive standard of care for the treatment of septic shock.

After screening for eligibility, patients meeting all inclusion and no exclusion criterion will be randomized. Patients will be randomized to one of three treatment arms.

Treatment with study drug must be initiated as early as possible, but no later than 24 hours after the onset of septic shock, defined by the start of vasopressor therapy.

Patients will be treated for at least 3 days with study drug. After the first 3 days of treatment, patients still requiring vasopressor will be treated until 24 hours after vasopressor withdrawal with a maximum treatment duration of 5 days.

Patients will be assessed at the End of Study (EoS) visit at day 28. After the last patient's day 28 visit, the study will be analyzed. Additional follow up (FU) visits will be conducted after 90 days, 6 and 12 months.

The objective of the study ist to compare the safety, tolerability and efficacy of two doses of nangibotide versus placebo, when given in addition to standard of care.


title: LBL 2018 - International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

summary:
Primary objectives:

Randomization R1, all patients eligible: To examine, whether the cumulative incidence of relapses with involvement of the CNS (CNS relapse, pCICR) can be decreased by a modified induction therapy including dexamethasone (experimental arm) instead of prednisone (standard arm)
Randomization R2, only patients with high risk LBL eligible: to examine, whether the probability of event-free survival (pEFS) in these patients can be improved by receiving an intensified treatment arm versus a standard treatment arm (as used in the EURO-LB 02)

ReferenceCitation: Khanam T, Sandmann S, Seggewiss J, Ruether C, Zimmermann M, Norvil AB, Bartenhagen C, Randau G, Mueller S, Herbrueggen H, Hoffmann P, Herms S, Wei L, Woeste M, Wuensch C, Gowher H, Oschlies I, Klapper W, Woessmann W, Dugas M, Burkhardt B. Integrative genomic analysis of pediatric T-cell lymphoblastic lymphoma reveals candidates of clinical significance. Blood. 2021 Apr 29;137(17):2347-2359. doi: 10.1182/blood.2020005381.

lead_sponsor: University Hospital Muenster

location_country:
Spain
Italy
Belgium
Czechia
Poland
Portugal
Austria
Russian Federation
Israel
Norway
Sweden
Slovakia
Switzerland
Hungary
China
Germany
Denmark
Ireland
Finland
France
Netherlands

location_facility: S.C. Ematologia Oncologica- Ospedale "Pausilipon"

location_facility: Oncoematologia Pediatrica IRCCS, Policlinico San Matteo Piazzale Golgi

location_facility: Pôle Femme Mère Enfant ; Unité d'Hématologie/Oncologie pédiatrique, CHU Angers

location_facility: Unità Autonoma di Oncoematologia Pediatrica, Dipartimento Pediatria - Azienda "A.Meyer"

location_facility: Divisione di Oncologia Pediatrica Ist. Nazionale Studio e Cura Tumori

location_facility: Divisione Ematologia - Oncologia Pediatrica, Clinica Pediatrica

location_facility: Service d'oncolologie, Hématologie pédiatrique. CHU Amiens, Avenue René Laënnec - SALOUEL

location_facility: Diakonie Neuendettelsau, Kliniken Hallerwiese / Cnopf'sche Kinderklinik, Pädiatrische Hämatologie /Onkologie

location_facility: Pôle mère enfant-Unité Hématologie - Oncologie pédiatrique - CHU Hôpital NORD

location_facility: Divisione di Pediatria- Ospedale "Casa Sollievo della Sofferenza"

location_facility: Hôpital de Enfants, Unité Onco-Hématologie Pédiatrique, Groupe Hospitalier Pellegrin

location_facility: Hématologie Oncologie pédiatrique, CHRU Besançon

location_facility: Clinica di Oncoematologia Pediatrica- Azienda Ospedaliera-Università di Padova

location_facility: Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University

location_facility: Instituto Português de Oncologia - Francisco Gentil - Porto

location_facility: University Hospital Gent Pediatrische hemato-oncologie

location_facility: Städtisches Klinikum Braunschweig gGmbH, Klinik für Kinder- und Jugendmedizin, Station K5 / Päd. Hämato- und Onkologie

location_facility: Klinikum Oldenburg AöR, Zentrum für Kinder- und Jugendmedizin, Abt. Hämatologie / Onkologie

location_facility: Asklepios Klinik St. Augustin GmbH, Kinder- und Jugendmedizin, Kinder-Hämatologie und Onkologie

location_facility: Klinikum Dortmund gGmbH, Klinik für Kinder- und Jugendmedizin, Station K1, Abt. Päd. Onkologie / Hämatologie

location_facility: Klinikum Mutterhaus der Borromäerinnen gGmbH, Pädiatrische Abteilung

location_facility: Complejo Hospitalario Universitario Insular Materno Infantil

location_facility: Children's Hospital at Soroka Medical Center

location_facility: Klinikum Schwabing, Kinderklinik der TU Päd. Hämatologie / Onkologie, Station 24d

location_facility: Department of Pediatric Hematology and Oncology, Silesian Medical University in Katowice

location_facility: Helsinki University Hospital, Department of Pediatric Hematology and Oncology

location_facility: Service Pédiatrie - Hématologie Immunologie Oncologie - CHU Toulouse

location_facility: Universitätsklinikum Aachen .Klinik für Kinder - und Jugendmedizin Hämatologie / Onkologie

location_facility: Klinikum Bremen-Mitte gGmbH, Prof.-Hess-Kinderklinik,Pädiatrische Onkologie und Hämatologie

location_facility: Universitätskliniken für Kinder- und Jugendmedizin, Päd. Hämatologie und Onkologie, Geb. 9

location_facility: Service d'hématologie et oncologie pédiatriques, Hôpital enfant-adolescent, CHU NANTES

location_facility: Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences

location_facility: Hospital Clínico Universitario de Valencia

location_facility: Klinikum Stuttgart, Olgahospital Zentrum für Kinder- und Jugendmedizin Pädiatrie 5 (Onkologie, Hämatologie, Immunologie)

location_facility: National Center for Pediatric Hematology, Oncology and Immunology Moscow

location_facility: Unité Onco- Hématologie Pédiatrique CHU Estaing 1 place Lucie-Aubrac

location_facility: Service Immuno-Hématologie Oncologie Pédiatrique

location_facility: Dept. of Pediatric Hematology and Oncology. University Hospital Motol and 2nd Medical School, Charles University

location_facility: Universitätsklinikum Schleswig Holstein Campus Kiel, Klinik für Allgemeine Pädiatrie, Päd. Onkologie / Hämatologie

location_facility: UAM Hématologie et Oncologie Pédiatrique, CHU de Montpellier - Hôpital Arnaud de Villeneuve

location_facility: U. O. di Pediatria- Azienda Ospedaliera Annunziata

location_facility: Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin

location_facility: Complejo Hospitalario Universitario de Vigo

location_facility: Gemeinschaftskrankenhaus Herdecke, Kinder- und Jugendmedizin, Päd. Hämatologie / Onkologie

location_facility: Universitätsklinikum Regensburg, Klinik für Kinder- und Jugendmedizin, Abt. Päd. Hämatologie, Onkologie, SZT

location_facility: Barnonkologiska avdelningen, Barn 3, Norrlands Universitetssjukhus

location_facility: Kuopio University Hospital, Department of Pediatric Hematology and Oncology

location_facility: Service de Pédiatrie et hématologie pédiatrique, CHU de Marseille - Hôpital de la Timone

location_facility: Univ.Klinik für Kinder- und Jugendheilkunde Innsbruck, Universitätsklinik für Pädiatrie I

location_facility: University Hospitals Leuven, Kinderhemato-oncologie

location_facility: Département de Pédiatrie et Génétique Médicale CHRU Morvan

location_facility: Service Oncologie-Hématologie pédiatrique CHU de Poitiers

location_facility: Hospital General Universitario Gregorio Marañón

location_facility: HELIOS Klinikum Krefeld, Zentrum für Kinder- und Jugendmedizin, Päd. Hämatologie/Onkologie

location_facility: Ruth Rappaport Children's Hospital, Rambam Medical Center

location_facility: Istituto di Clinica Pediatrica- Ospedale Regionale Microcitemie

location_facility: University Hospital of Oulu, Paediatric Haematology and Oncology

location_facility: Hospital Clínico Universitario de Santiago

location_facility: University Hospital Brussels, Pediatrische oncologie

location_facility: Dip. Scienze Pediatriche e dell'Adolescenza Ospedale Infantile Regina Margherita

location_facility: Børneonkologisk afsnit 5054, BørneUngeKlinikken, Juliane Marie Centret, Rigshospitalet

location_facility: Aarhus University Hospital, Department of Pediatrics

location_facility: Department of Pediatric Hematology and Oncology, Center of Pediatrics and Oncology in Chorzów

location_facility: Dana Children's Hospital, Tel-Aviv Sourasky Medical Center

location_facility: Universitätsklinikum Gießen und Marburg, Standort Gießen, Zentrum für Kinderhämatologie und -onkologie

location_facility: Universitätsklinikum Leipzig, Klinik für Kinder und Jugendliche, Abt. Päd. Hämatologie / Onkologie

location_facility: Universitätsklinikum Frankfurt, Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie und Onkologie

location_facility: Universitätsklinikum Greifswald KdöR, Klinik und Poliklinik für Kinder- und Jugendmedizin, Abt. Pädiatrische Onkologie und Hämatologie

location_facility: Service onco hématologie pédiatrique CHU de Grenoble site Nord - Hôpital Couple enfant

location_facility: LKH Salzburg, Universitätsklinik für Kinder- und Jugendheilkunde, Kinderonkologie

location_facility: Barncancercentrum, Drottning Silvias Barn och Ungdomssjukhus, Sahlgrenska Universitetssjukhuset

location_facility: Department of Pediatric Oncology and Hematology, Center of Pediatrics in Kielce

location_facility: Universitätsklinikum Rostock, Kinder- und Jugendklinik, Päd. Hämatologie und Onkologie

location_facility: Universitätsklinikum Düsseldorf, Zentrum für Kinder- und Jugendmedizin, Klinik für Päd. Hämatologie und Onkologie

location_facility: Universitätsklinikum Freiburg, Zentrum für Kinder- und Jugendmedizin, Klinik IV: Päd. Hämatologie und Onkologie

location_facility: Oncologia Pediatrica,- Ospedale "R. Silvestrini"

location_facility: Vestische Kinderklinik, Universität Witten / Herdecke

location_facility: Univ.Klinik für Kinder- und Jugendheilkunde Graz, Klin. Abteilung für pädiatrische Hämato-Onkologie

location_facility: Unité d'hématologie pédiatrique CHRU de Lille - Hôpital Jeanne de Flandre

location_facility: Service d'Hématologie - Oncologie pédiatrique CHU Limoges - Hôpital de la mère et de l'enfant

location_facility: Hospital Infantil Universitario Niño Jesús

location_facility: Department of Pediatric Oncology/Hematology, Institute of Pediatrics, Medical College Jagiellonian University

location_facility: Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk

location_facility: Hospital Clínico Universitario Virgen de la Arrixaca

location_facility: Dipartimento di Ematologia e Oncologia Pediatrica Istituto " G. Gaslini"

location_facility: U.O. Emato-Oncologia Pediatrica- Università degli studi di Trieste-Ospedale Infantile Burlo Garofolo

location_facility: Dipartimento di Medicina Clinica e Sperimentale Sezione di Pediatria - Università di Ferrara

location_facility: service d'oncologie pédiatrique, institut Curie

location_facility: Service d'hémato-oncologie pédiatrique CHU NICE - Hôpital l'Archet 2

location_facility: Edmond and Lily Safra Children's Hospital, Sheba Medical Center

location_facility: Barnonkologiska enheten, Barn och Ungdomsmedicinska kliniken, Universitetssjukhuset i Linköping

location_facility: Universitätsklinikum Essen, Zentrum für Kinder- und Jugendmedizin, Hämatologie / Onkologie

location_facility: Carl-Thiem-Klinikum, Kinderklinik, Station 5e

location_facility: Dipartimento Pediatrico degli OO.RR. di Bergamo

location_facility: H.C. Andersens Children Hospital, Odense University Hospital

location_facility: Department of Pediatric Oncology and Hematology, Provincial Specialist Children's Hospital

location_facility: Department of pediatric hematology and oncology, National Institute of Children's Diseases

location_facility: Clinica Pediatrica Ospedale S. Gerardo Via Donizetti

location_facility: U.O. Oncoematologia Pediatrica- Policlinico "G.B. Rossi"

location_facility: Universitätsklinikum Magdeburg A. ö. R., Kinderklinik, Päd. Hämatologie / Onkologie

location_facility: Universitätsklinikum Jena, Klinik für Kinder- und Jugendmedizin

location_facility: HELIOS Klinikum Erfurt GmbH, Klinik für Kinder- und Jugendmedizin, Päd. Onkologie / Hämatologie

location_facility: Universitätsklinikum Hamburg Eppendorf, Zentrum für Kinder- und Jugendmedizin, Abt. Pädiatrische Hämatologie und Onkologie

location_facility: Klinikum der LMU, Dr. von Haunersches Kinderspital, Pädiatrische Hämatologie / Onkologie

location_facility: Hospital General Universitario de Alicante

location_facility: Universitätsklinikum Halle (Saale), Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie / Onkologie

location_facility: Hospital Regional Universitario de Málaga

location_facility: Oncoematologia Pediatrica- Ospedale dei Bambini G. di Cristina

location_facility: Dipartimento di Ematologia -Ospedale Civile

location_facility: U.O. di Ematologia, Oncologia e Trapianto-Azienda Policlinico di Modena

location_facility: Universitäts-Kinderspital beider Basel (UKBB)

location_facility: Children's Hospital at Hadassah, Ein Kerem Medical Center

location_facility: Instituto Português de Oncologia - Francisco Gentil - Libosa

location_facility: CHR Citadelle Hémato - oncologie pédiatrique

location_facility: Universitätsklinikum Erlangen, Klinik für Kinder- und Jugendmedizin, Pädiatrische Onkologie / Hämatologie

location_facility: Centro Hospitalar e Universitário de Coimbra

location_facility: CHUV - Centre Hospitalier Universitaire Vaudois

location_facility: Service d'immuno-hématologie pédiatrique et de transplantation de moelle osseuse, CHU de Lyon HCL - GH Est-Institut d'hématologie et d'oncologie pédiatrique IHOP

location_facility: Klinikum Augsburg ,Schwäbisches Kinderkrebszentrum. I. Klinik für Kinder und Jugendliche Hämatologie / Onkologie

location_facility: Service Hémato-immuno- oncologie- CHU PARIS Armand Trousseau

location_facility: Department of Pediatrics, Children Hematology nad Oncology, Pomeranian Medical University

location_facility: Evangelisches Krankenhaus Bielefeld GmbH, Klinik für Kinder- und Jugendmedizin, Hämatologie und Onkologie

location_facility: Johannes Wesling Klinikum Minden, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie / Onkologie, Station E 22

location_facility: Department of pediatric hematology and oncology, Children´s University Hospital

location_facility: Department of Pediatric Oncology and Hematology, Medical University of Bialystok

location_facility: HELIOS Kliniken Schwerin GmbH, Klinik für Kinder- und Jugendmedizin, Station A1

location_facility: Luzerner Kantonspital - Kinderspital Luzern

location_facility: University Hospital Aalborg, Nord, Department of Pediatrics

location_facility: Department of Paediatric Oncology and Haematology, University of Rzeszów, Department of Pediatrics

location_facility: service d'oncologie pédiatrique, hopital Félix Guyon

location_facility: Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin, Abt. Pädiatrische Hämatologie und Onkologie

location_facility: Princess Maxima Centre for Pediatric Oncology

location_facility: Klinikum Kassel Gesundheit Nordhessen Holding AG, Klinik für pädiatrische Hämatologie und Onkologie

location_facility: Dipartimento di Scienze Pediatriche Mediche Chirurgiche Ospedale Sant'Orsola Malpighi

location_facility: Hôpital Universitaire des Enfants Reine Fabiola (ULB), Pédiatrie hémato-oncologie

location_facility: Service d'Onco-Hematologie Pediatrique CHU STRASBOURG -Hôpital de Hautepierre

location_facility: U.O. di Pediatria e Oncoematologia Pediatrica. Az. Osp. di Parma

location_facility: Service d'hémato-oncologie pédiatrique- CHU de Nancy - Hôpital de Brabois Enfant

location_facility: Hospital Universitari i Politècnic La Fe

location_facility: U.O. Pediatria Ospedale Infermi- Azienda USL Rimini

location_facility: Pôle pédiatrie Hémato-cancérologie pédiatrique- CHU RENNES - Hôpital sud

location_facility: Service d'Hemato-Oncologie Pediatrique CHU Rouen

location_facility: Klinikum Mannheim gGmbH, Universitäts-Kinderklinik, Päd. Onkologie /Hämatologie

location_facility: Hospital Universitario Virgen de las Nieves

location_facility: Klinikum Chemnitz gGmbH, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie und Onkologie

location_facility: Universitätsklinikum Schleswig Holstein Campus Lübeck, Klinik für Kinder- und Jugendmedizin, Hämatologie und Onkologie

location_facility: Gemeinschaftsklinikum Mittelrhein Kemperhof, Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie und Onkologie

location_facility: Oncological center of regional Children's Hospital

location_facility: Department of pediatric oncology and hematology, Children´s Faculty Hospital

location_facility: Department of Pediatric Oncology, Children's Memorial Health Institute

location_facility: Charité Campus Virchow-Klinikum, Zentrum für Kinder- und Jugendmedizin- Abt. Hämatologie / Onkologie

location_facility: Dipartimento Biomedicina Età Evolutiva- U.O. Pediatrica I Policlinico

location_facility: Zentrum für Kinderheilkunde der Universität Bonn, Abt. Päd. Hämatologie / Onkologie

location_facility: HELIOS Klinikum Berlin-Buch, Kinderklinik, Pädiatrische Hämatologie und Onkologie

location_facility: Universitätsklinikum Ulm, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie und Onkologie

location_facility: Unité d'hémato-immuno-oncologie pédiatrique. Centre Hospitalier Universitaire niveau 1 - bâtiment FEH

location_facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Zentrum für Kinder- und Jugendmedizin, Pädiatrische Hämatologie / Onkologie

location_facility: Hospital Universitario Nuestra Señora de Candelaria

location_facility: Barnavdelningen för blod- och tumörsjukdomar 95A, Akademiska sjukhuset

location_facility: Department of Bone Marrow Transplantation, Children Oncology and Hematology, Wroclaw Medical University

location_facility: Cliniques Universitaires Saint-Luc (UCL), Hématologie et oncologie pédiatrique

location_facility: Städtisches Klinikum Karlsruhe gGmbH, Kinderklinik, Station S 24

location_facility: Divisione di Ematologia Pediatrica- Ospedale "Bambino Gesù". Istituto di Ricerca Scientifica

location_facility: Universitäts-Kinderklinik Heidelberg, Abt. Hämatologie / Onkologie

location_facility: Medizinische Hochschule Hannover, Kinderheilkunde, Päd. Hämatologie / Onkologie

location_facility: Klinikum der Universität zu Köln, Klinik für Kinder- und Jugendmedizin, Abt. Kinderonkologie und -hämatologie

location_facility: Sezione Ematologia- Dipart. Biotecnico Cellulare ed Ematologia- Università "La Sapienza"

location_facility: Barncanceravdelningen Astrid Lindgrens Barnsjukhus, Nya Karolinska Universitetssjukhuset

location_facility: Dept. of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University Cernopolni

location_facility: Universitätsklinik Carl Gustav Carus der TU Dresden, Klinik für Kinder- und Jugendmedizin

location_facility: Georg-August-Universität Universitäts-Kinderklinik, Pädiatrie I

location_facility: Department of Pediatrics, Oncology, Hematology and Diabetology, Institute of Pediatrics, Medical University of Lodz

location_facility: Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw

location_facility: Service d'Hémato-Oncologie Pédiatrique- American Hospital

location_facility: Tampere University Hospital, Paediatric Haematology and Oncology

location_facility: Turku University Hospital, Paediatric and Adolescent Haematology and Oncology

location_facility: Schneider Children's hospital, Rabin Medical Center

location_facility: Kepler Universitätsklinikum, Med Campus IV / Onkologie

location_facility: Universitätskinderklinik Würzburg, Päd. Onkologie und Hämatologie

location_facility: Hospital Clínico Universitario de Valladolid

location_facility: Clinica Pediatrica, Centro Regionale Oncoematologia Pediatrica- Ospedale dei Bambini "G. Salesi"

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Universitätsklinik Tübingen, Klinik für Kinderheilkunde und Jugendmedizin, Päd. Hämatologie / Onkologie

location_facility: Service d' hémato-immunologie CHU Paris - Hôpital Robert Debré


acronym: HOVON 156 AML

title: A Phase 3, Multicenter, Open-label, Randomized, Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes With Excess Blasts-2 (MDS-EB2) With FLT3 Mutations Eligible for Intensive Chemotherapy (HOVON 156 AML / AMLSG 28-18)

lead_sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland

location_country: Luxembourg Spain Ireland Austria Australia Netherlands Finland Lithuania Switzerland Sweden France Belgium Norway Germany

location_facility:
BE-Brugge-AZBRUGGE
FR-Tours cedex-BRETONNEAU
DE-Bonn-UNIBONN
AU-Melbourne-SVHM
IE-Dublin 7-MATER
NO-Oslo-OSLOUH
NL-Groningen-UMCG
ES-Barcelona-PARCDESALUTMAR
IE-Dublin 4-SVUH
ES-Palma-HSLL
FR-Clamart-HIAPERCY
FR-Nice-CAL
NL-Rotterdam-ERASMUSMC
CH-St. Gallen-KSSG
DE-Ulm-UNIKLINKULM
BE-Yvoir-MONTGODINNE
DE-Wuppertal-HELIOSGESUNDHEIT
DE-Mainz-UNIMEDIZINMAINZ
IE-Co. Limerick-UHL
AT-Vienna-HANUSCH
FR-Angers-CHUANGERS
NL-Leiden-LUMC
AU-Perth-FSH
NO-Stavanger-HELSESTAVANGER
CH-Fribourg-HFR
FR-Rouen cedex-BECQUEREL
DE-Hamm-EVKHAMM
DE-Luedenscheid-KLINIKUMLUEDENSCHEID
DE-München-IRZTUM
AU-Adelaide-RAH
NL-Leeuwarden-MCL
FI-Helsinki-HUS
CH-Luzern-LUKS
NL-Amsterdam-VUMC
CH-Zürich-USZ
NL-Amersfoort-MEANDERMC
DE-Essen-KEM
DE-Saarbrücken-CARITASKLINIKUM
BE-Brussel-UZBRUSSEL
IE-Dublin 24-TUH
DE-Homburg-UNIKLINIKSAARLAND
ES-Madrid-CSGREGORIOMARANON
FR-Poitiers-CHUPOITERS
DE-Goch-KKLE
IE-Dublin 8-STJAMES
BE-Hasselt-VIRGAJESSE
SE-Stockholm-KAROLINSKAHUDDINGE
DE-Herne-MARIENHOSPITALHERNE
AU-Melbourne-AUSTIN
DE-Dortmund-JOHODORTMUND
DE-Hamburg-ASKLEPIOSSTGEORG
NL-Amsterdam-OLVG
AU-Hobart TAS-RHOBART
AU-Canberra-CANBERRAHOSPITAL
DE-Tübingen-MEDUNITUEBINGEN
AU-Brisbane-RBWH
AU-Melbourne-MONASH
FR-Strasbourg cedex-HAUTEPIERRE
CH-Bern-INSEL
NL-Utrecht-UMCUTRECHT
CH-Basel-USB
ES-Barcelona-MUTUATERRASSA
DE-Lübeck-UKSHLUBECK
AU-Sydney-CONCORD
DE-Heilbronn-SLK
DE-Passau-KLINIKUMPASSAU
FR-Lens-CHLENS
FR-Nice-LARCHET
AU-Sydney-WSAH
DE-Berlin-VIVANTESURBAN
NL-Zwolle-ISALA
ES-Palma-SSIB
NL-Amsterdam-AMC
NL-Breda-AMPHIA
DE-Lemgo-KLINIKUMLIPPE
DE-Hamburg-UKE
IE-Galway-UHGALWAY
IE-Cork-CUH
DE-Lebach-CARITASKHLEBACH
DE-Minden-MUEHLENKREISKLINKEN
ES-Valencia-MALVARROSA
DE-Berlin-CAMPUSMITTE
DE-Oldenburg-KLINIKUMOLDENBURG
CH-Geneve (14)-HCUGE
AU-Waratah-CALVARYMATER
FR-Paris cedex 10-SAINTLOUIS
NO-Bergen-HELSEBERGEN
ES-Tarragona-JOAN
FR-Bayonne-CHCOTEBASQUE
FI-Tampere-TAYS
AT-Linz-ORDENSKLINIKUM
DE-Bad Saarow-HELIOSBADSAAROW
DE-Frankfurt-KLINIKUMFRANKFURT
AU-Sydney-RNSH
DE-Trier-MUTTERHAUS
AU-Melbourne-BOXHILL
FR-Limoges-CHULIMOGES
FR-Bobigny-AVICENNE
FR-Clermont-Ferrand-ESTAING
AU-Launceston TAS-LAUNCESTON
BE-Antwerpen Edegem-UZA
AU-Geelong VIC-BARWONHEALTH
AU-Gosford NSW-GOSFORDHOSPITAL
DE-Bochum-RUB
FR-Montpellier-STELOI
AT-Linz-KEPLER
ES-Lleida-ICSVILANOVA
FR-Marseille-IPC
BE-Roeselare-AZDELTA
ES-Barcelona-ICODURANREYNALS
St George Hospital
DE-Meschede-HOCHSAUERLAND
FR-Nantes-CHUNANTES
NL-Enschede-MST
FR-Villejuif-GUSTAVEROUSSY
AU-Adelaide-FLINDERS
ES-Barcelona-GERMANTRIALS
DE-Bremen-KBM
DE-Berlin-VIVANTESNEUKOLLN
DE-Greifswald-UNIGREIFSWALD
BE-Mons-AMBROISE
FR-Reims-CHREIMS
SE-Uppsala-UPPSALAUH
DE-Regensburg-UKR
DE-Berlin-CAMPUSBENFRANKLIN
FR-Vandoeuvre Les Nancy-CHRUNANCY
NL-Nieuwegein-ANTONIUS
DE-Hanau-KLINIKUMHANAU
AT-Salzburg-SALK
AU-Sydney-NEPEAN
BE-Leuven-UZLEUVEN
DE-Esslingen-KLINIKUMESSLINGEN
DE-Aschaffenburg-KLINIKUMAB
NL-Eindhoven-MAXIMAMC
BE-Bruxelles-STLUC
DE-Düsseldorf-MEDUNIDUESSELDORF
FR-Rennes cedex 9-CHURENNES
FR-Grenoble cedex 9-CHUGRENOBLE
DE-Stuttgart-KLINIKUMSTUTTGART
DE-Ludwigshafen-KLILU
DE-Mainz-KLINKUNIMAINZ
NL-Arnhem-RIJNSTATE
FR-Toulouse-CHUTOULOUSE
BE-Haine-Saint-Paul-JOLIMONT
AU-Douglas-TOWNSVILLE
DE-Magdeburg-OVGU
DE-Karlsruhe-KLINIKUMKARLSRUHE
BE-Gent-UZGENT
DE-Darmstadt-KLINIKUMDARMSTADT
DE-Kaiserslautern-WESTPFALZ
DE-Offenburg-ORTENAUKLINIKUM
FR-Le Chesnay cedex-CHVERSAILLES
AT-Innsbruck-IMED
BE-Brussel-BORDET
AU-Perth-RPH
LU-Luxembourg-CHL
BE-Liege-CHRCITADELLE
DE-Villingen-Schwenningen-SBKVS
CH-Lausanne-CHUV
BE-Liege-CHULIEGE
DE-Braunschweig-KLINIKUMBRAUNSCHWEIG
DE-Hamburg-ASKLEPIOS
ES-Malaga-HUVV
CH-Bellinzona-IOSI
IE-Dublin 9-BEAUMONT
NL-Den Bosch-JBZ
AU-Melbourne-RMELBOURNE
AU-Melbourne-ALFRED
FR-Besançon Cedex-JEANMINJOZ
CH-Aarau-KSA
FR-Lyon Pierre Benite cedex-LYONSUD
NL-Delft-RDGG
DE-Hannover-MHHANNOVER
FR-Lille-CHULILLE
AU-Perth-SCGH
DE-Giessen-UKGM
FR-Argenteuil-CHARGENTEUIL
NL-Maastricht-MUMC
NO-Tromsø-NORTHNOORWEGEN
ES-Girona-ICSTRUETA
DE-Hannover-SILOAHKRH
FR-Saint-Priest-en-Jarez-ICLOIRE
FR-Lyon-LEONBERARD
FR-Amiens-CHUAMIENS
DE-Berlin-CAMPUSVIRCHOW
LT-Vilnius-SANTA
ES-Barcelona-CLINICUB
SE-Lund-SUH
BE-Antwerpen-ZNASTUIVENBERG
NL-Den Haag-HAGA
FR-Paris cedex 15-NECKER
NO-Trondheim-STOLAV
NL-Nijmegen-RADBOUDUMC
DE-Flensburg-MALTESER
NL-Dordrecht-ASZ
AT-Graz-MEDUNIGRAZ
AU-Camperdown-RPA
DE-Stuttgart-DIAKSTUTTGART
ES-Barcelona-SANTPAU
FR-Pessac Cedex-CHUBORDEAUX
AU-Brisbane-PAH
ES-Barcelona-VHEBRON

summary: Activating mutations in the fms like tyrosine kinase 3 (FLT3) gene are observed in approximately 30% of patients with newly diagnosed acute myeloid leukemia (AML). Addition of the multitargeted kinase inhibitor midostaurin to standard chemotherapy prolongs event-free survival (EFS) and overall survival (OS) in patients with a FLT3 mutation. Gilteritinib is a more potent and more specific inhibitor of mutant FLT3 in comparison to midostaurin and has shown promising clinical activity in AML.


title: A Phase 2b, Open-label, Efficacy and Safety Study of ABX464 as Maintenance Therapy in Patients With Moderate to Severe Ulcerative Colitis

summary: A phase 2b study to evaluate the long-term efficacy and safety study of ABX464 50mg as maintenance therapy in patients with moderate to severe Ulcerative Colitis.

ReferenceCitation: Vermeire S, Sands BE, Tilg H, Tulassay Z, Kempinski R, Danese S, Bunganic I, Nitcheu J, Santo J, Scherrer D, Biguenet S, Ehrlich HJ, Steens JM, Gineste P, Sandborn WJ. ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension. Lancet Gastroenterol Hepatol. 2022 Nov;7(11):1024-1035. doi: 10.1016/S2468-1253(22)00233-3. Epub 2022 Sep 6.

lead_sponsor: Abivax S.A.

location_country:
Poland
Belarus
Serbia
Italy
Austria
Slovenia
Spain
Canada
United Kingdom
Ukraine
Hungary
France
Belgium
Germany
Slovakia
Czechia

location_facility: Nottingham University Hospitals Queen's Medical Centre

location_facility: CI City Clinical Hospital #6 Dept of Gastroenterology

location_facility: Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska

location_facility: Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

location_facility: Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin

location_facility: Fondazione Poliambulanza Istituto Ospedaliero

location_facility: Communal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital

location_facility: Szpital Uniwersytecki nr 2 im.dr J. Biziela

location_facility: Vasutegeszsegugyi Kft. - Debreceni Egeszsegugyi Kozpont

location_facility: Santa Familia Centrum Badan, Profilaktyki i Leczenia

location_facility: CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

location_facility: Azienda Ospedaliero Universitaria Mater Domini

location_facility: Central City Clinical Hospital Dept of Theraphy No. 2 SHEI Ivano-Frankivsk NMU

location_facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

location_facility: CNE Cherkasy Regional Hospital of Cherkasy Regional Council

location_facility: Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

location_facility: Clinical Center " Dr Dragisa Misovic Dedinje"

location_facility: Klinikum der Johann Wolfgang Goethe-Universitaet

location_facility: Centre Hospitalier Départemental Les Oudairies

location_facility: Ordensklinikum Linz GmbH - Barmherzige Schwestern

location_facility: Studiengesellschaft BSF Unternehmergesellschaft haftungsbeschraenkt

location_facility: I.I.Mechnykov Dnipropetrovsk Regional Clinical Hospital

location_facility: CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC

location_facility: CHU Clermont Ferrand - Hôpital d'Estaing

location_facility: Hospital Universitario de Gran Canaria Dr. Negrin

location_facility: University Hospitals Leuven - campus Gasthuisberg

location_facility: M.I. Pyrogov VRCH Dept of Gastroenterology M.I. Pyrogov VNMU

location_facility: Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital

location_facility: Vitebsk regoinal clinical specialized center

location_facility: Lviv Regional Clinical Hospital D.Halytskyi Lviv NMU

location_facility: Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)

location_facility: A. Novak Transcarpathian Regional Clinical Hospital