title: A Randomized, Double-Blind, Phase 3 Study Evaluating the Safety and Efficacy of Venetoclax in Combination With Azacitidine in Patients Newly Diagnosed With Higher-Risk Myelodysplastic Syndrome (Higher-Risk MDS)

acronym: Verona

summary:
Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia (AML), and a risk of death from the disease itself. Symptoms of MDS include fatigue, shortness of breath, unusual paleness due to anemia (low red blood cell count), easy or unusual bruising, and red spots just beneath the skin caused by bleeding. The purpose of this study is to see how safe and effective venetoclax and azacitidine (AZA) combination are when compared to AZA and a placebo (contains no medicine), in participants with newly diagnosed higher-risk MDS.

Venetoclax is an investigational drug being developed for the treatment of MDS. The study consists of two treatment arms - In one arm, participants will receive venetoclax and AZA. In another arm, participants will receive AZA and placebo. Adult participants with newly diagnosed higher-risk MDS will be enrolled. Around 500 participants will be enrolled in approximately 220 sites worldwide.

Participants in one arm will receive oral doses of venetoclax tablet and intravenous (infusion in the vein) or subcutaneous (given under the skin) AZA solution. Participants in another arm will receive oral doses of placebo tablet and intravenous or subcutaneous AZA solution.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.

status: Active, not recruiting

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Japan
Czechia
Poland
Austria
Australia
Russian Federation
Puerto Rico
Israel
Turkey
Brazil
Canada
Hungary
China
Germany
Taiwan
Korea, Republic of
France
Netherlands

location_facility: Tennessee Oncology-Nashville Centennial /ID# 220854

location_facility: The First Affiliated Hospital of Nanchang University /ID# 225983

location_facility: Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 223727

location_facility: Liga Paranaense de Combate ao Câncer /ID# 221341

location_facility: Hacettepe University Faculty of Medicine /ID# 222094

location_facility: MTZ Clinical Research Powered by Pratia /ID# 221354

location_facility: Novant Health Presbyterian Medical Center /ID# 222561

location_facility: Novant Health Forsyth Medical Center /ID# 221004

location_facility: Hospital General Universitario Gregorio Maranon /ID# 221271

location_facility: Fukushima Medical University Hospital /ID# 222015

location_facility: Texas Oncology - Forth Worth /ID# 223777

location_facility: Henan Provincial People's Hospital /ID# 225790

location_facility: Gold coast University Hospital /ID# 222606

location_facility: CHU de Nantes, Hotel Dieu -HME /ID# 222074

location_facility: Torrance Memorial Physician Network Cancer Care /ID# 222702

location_facility: LUX MED Onkologia - Szpital Szamocka /ID# 222203

location_facility: West China Hospital, Sichuan University /ID# 221601

location_facility: Zhongda Hospital Southeast University /ID# 221849

location_facility: Weill Cornell Medical College /ID# 222898

location_facility: Peking University International Hospital /ID# 222987

location_facility: Nanfang Hospital of Southern Medical University /ID# 224566

location_facility: Hospital Universitario Germans Trias i Pujol /ID# 221274

location_facility: Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 221003

location_facility: Fakultni nemocnice Hradec Kralove /ID# 221163

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 221702

location_facility: Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 233321

location_facility: Republican hospital named after V.A. Baranov /ID# 221214

location_facility: University Hospitals Bristol NHS Foundation Trust /ID# 222510

location_facility: Helen F. Graham Cancer Center & Research Institute /ID# 223731

location_facility: Hospital Universitario Virgen del Rocio /ID# 221276

location_facility: Shanghai Sixth People's Hospital /ID# 221546

location_facility: Universitaetsklinikum Duesseldorf /ID# 221169

location_facility: Tianjin Medical University General Hospital /ID# 226810

location_facility: Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie /ID# 221667

location_facility: VA Caribbean Healthcare System /ID# 221012

location_facility: CHUQ- Hôpital de l'Enfant-Jesus /ID# 221200

location_facility: Shaanxi Provincial people's Hospital /ID# 225728

location_facility: Ustav hematologie a krevni transfuze /ID# 221350

location_facility: Universitatsklinikum Mannheim /ID# 221172

location_facility: Shengjing Hospital of China Medical University /ID# 222945

location_facility: McGill University Health Center Research Institute /ID# 222519

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 221705

location_facility: Medizinische Hochschule Hannover /ID# 221173

location_facility: Tel Aviv Sourasky Medical Center /ID# 221896

location_facility: Pusan National University Hospital /ID# 232353

location_facility: The Fourth Affiliated Hospital Zhejiang University School of Medicine /ID# 225918

location_facility: The Second Hospital of Hebei Medical University /ID# 222919

location_facility: Klinikum rechts der Isar - Technische Universitaet Muenchen /ID# 221170

location_facility: Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 221703

location_facility: Erciyes University Medical Fac /ID# 222090

location_facility: Dana-Farber Cancer Institute /ID# 219162

location_facility: Pontchartrain Cancer Center - Covington /ID# 221005

location_facility: New York Oncology Hematology - Albany Cancer Center /ID# 223778

location_facility: Fejer Megyei Szent Gyorgy Korhaz /ID# 222953

location_facility: CHU Bordeaux - Hopital Haut Leveque /ID# 220989

location_facility: Stauferklinikum Schwaebisch Gmuend /ID# 224917

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz Josa Andras Okta /ID# 221704

location_facility: Cardiff & Vale University Health Board /ID# 221236

location_facility: VA Puget Sound Health Care System /ID# 221358

location_facility: Virginia Cancer Institute at Reynolds Crossing /ID# 221002

location_facility: St Vincent's Hospital Melbourne /ID# 221809

location_facility: University Hospital Plymouth NHS Trust /ID# 222514

location_facility: Hospital Universitario Vall d'Hebron /ID# 221323

location_facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221784

location_facility: Lanzhou University Second Hospital /ID# 225980

location_facility: CHU de Nice - Hôpital Archet 1 /ID# 220992

location_facility: Florida Cancer Specialists - Fort Myers /ID# 221319

location_facility: CHU UCL Namur - site Godinne /ID# 219064

location_facility: Kaluga Regional Clinical Hospital /ID# 221211

location_facility: Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli /ID# 220816

location_facility: Ordensklinikum Linz GmbH Elisabethinen /ID# 221387

location_facility: Baylor Scott & White Medical Center- Temple /ID# 221332

location_facility: Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 221475

location_facility: Comprehensive Cancer Centers of Nevada - Horizon Ridge /ID# 222635

location_facility: The Chaim Sheba Medical Center /ID# 221110

location_facility: Hospital Universitario de Salamanca /ID# 221297

location_facility: University Hospitals Dorset NHS Foundation Trust /ID# 221237

location_facility: Florida Cancer Specialists - Panhandle /ID# 221315

location_facility: Hospital Universitario Quironsalud Madrid /ID# 221275

location_facility: Willamette Valley Cancer Institute and Research Center /ID# 223733

location_facility: China Medical University Hospital /ID# 218987

location_facility: Sunnybrook Health Sciences Ctr /ID# 219103

location_facility: Universitaetsklinikum Leipzig /ID# 221168

location_facility: Florida Cancer Specialists - East /ID# 221317

location_facility: Utah Cancer Specialists Salt Lake Clinic /ID# 219160

location_facility: Florida Cancer Specialists - North /ID# 221318

location_facility: Sociedade Beneficente Israelita Hospital Albert Einstein /ID# 221370

location_facility: Guangdong Provincial People's Hospital /ID# 221442

location_facility: Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 220819

location_facility: Nagasaki University Hospital /ID# 222241

location_facility: Seoul National University Hospital /ID# 221226

location_facility: Texas Oncology - Northeast Texas /ID# 223734

location_facility: Rocky Mountain Cancer Centers /ID# 223723

location_facility: University of Fukui Hospital /ID# 221568

location_facility: University of California, Los Angeles /ID# 221760

location_facility: Maryland Oncology Hematology /ID# 223776

location_facility: Oxford University Hospitals NHS Foundation Trust /ID# 221231

location_facility: Ottawa Hospital Research Institute /ID# 219105

location_facility: Massachusetts General Hospital /ID# 225068

location_facility: Hospital Universitario Reina Sofia /ID# 221273

location_facility: Texas Oncology - Medical City Dallas /ID# 223725

location_facility: National Hospital Organization Mito Medical Center /ID# 222278

location_facility: Ondokuz mayis University Facul /ID# 222091

location_facility: The First Affiliated Hospital of Soochow University /ID# 221640

location_facility: University Hospitals Birmingham NHS Foundation Trust /ID# 221233

location_facility: Rush University Medical Center /ID# 221007

location_facility: Virginia Cancer Specialists - Gainesville /ID# 223726

location_facility: National Cheng Kung University Hospital /ID# 218989

location_facility: Akdeniz Universitesi Tip Fakul /ID# 222095

location_facility: Kaohsiung Chang Gung Memorial Hospital /ID# 223573

location_facility: Northwestern University Feinberg School of Medicine /ID# 220843

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 220991

location_facility: Port Macquarie Base Hospital /ID# 234078

location_facility: Tennessee Oncology - Chattanooga / McCallie /ID# 221311

location_facility: Oncology Hematology Care, Inc. /ID# 223724

location_facility: Vseobecna fakultni nemocnice v Praze /ID# 221229

location_facility: Klinikum Wels-Grieskirchen GmbH /ID# 221386

location_facility: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 221567

location_facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo /ID# 221339

location_facility: Uniwersyteckie Centrum Kliniczne /ID# 222069

location_facility: St. Luke's Mountain State Tumor Institute /ID# 220838

location_facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 220810

location_facility: Hadassah Medical Center-Hebrew University /ID# 222006

location_facility: Hospital Universitario 12 de Octubre /ID# 221272

location_facility: The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 221494

location_facility: Seoul National University Bundang Hospital /ID# 221695

location_facility: Hospital Universitario Walter Cantidio /ID# 223434

location_facility: Beth Israel Deaconess Medical Center /ID# 225069

location_facility: Medizinische Universitaet Wien /ID# 221446

location_facility: Hospital Universitário Pedro Ernesto /ID# 223080

location_facility: CIUSSS du Nord-de-l'ile-de-Montréal_Hopital du Sacré-Coeur de Montréal /ID# 218973

location_facility: Stony Brook University Hospital /ID# 224450

location_facility: AP-HM - Hopital de la Conception /ID# 224882

location_facility: Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 220818

location_facility: Hospital Universitario y Politecnico La Fe /ID# 221270

location_facility: CHU Grenoble - Hopital Michallon /ID# 220988

location_facility: VA Ann Arbor Healthcare System /ID# 221365

location_facility: MD Anderson Cancer Center at Texas Medical Center /ID# 219163

location_facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 225982

location_facility: Kobe City Medical Center General Hospital /ID# 221977

location_facility: PIH Health Whittier Hospital /ID# 222647

location_facility: Virginia Commonwealth University Medical Center Main Hospital /ID# 221590

location_facility: Yamagata University Hospital /ID# 221574

location_facility: Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 221189

location_facility: Yonsei University Health System Severance Hospital /ID# 233171

location_facility: Maastricht Universitair Medisch Centrum /ID# 221630

location_facility: Providence Medical Foundation /ID# 222633

location_facility: Universitair Ziekenhuis Leuven /ID# 218905

location_facility: Texas Oncology - Austin Midtown /ID# 223729

location_facility: Zhujiang Hospital of Southern Medical University /ID# 222071

location_facility: The Royal Marsden NHS Foundation Trust /ID# 221232

location_facility: University College London Hospitals NHS Foundation Trust /ID# 221240

location_facility: Almazov National Medical Research Centre /ID# 221449

location_facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 221092

location_facility: Pan American Center for Oncology Trials, LLC /ID# 221010

location_facility: Texas Oncology - San Antonio Medical Center /ID# 223728

location_facility: Tongji Hospital Tongji Medical College of HUST /ID# 221474


type: Other Identifier

title: Comparison of Nicotinamide and Sevelamer Hydrochloride on Phosphatemia Control on Chronic Hemodialysed Patients

acronym: NICOREN

summary: The comparison between nicotinamide and sevelamer aims to demonstrate, in chronic hemodialysed patients, the non-inferiority of nicotinamide in terms of control of the phosphatemia. Secondary objectives is to compare the two treatments in terms of efficiency in other biological parameters, vascular calcification and bone mass loss and on the clinical and biological tolerance and finally to explore the roles of metabolites of nicotinamide.

status: Terminated

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

ReferenceType: background

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lead_sponsor: Centre Hospitalier Universitaire, Amiens

location_facility: Association Régionale Promotion Dialyse à domicile (ARPDD)

location_facility: Association pour le Développement de l'Hémodialyse

intervention_type: Drug

lead_sponsor_type: academique

status_simplified: Unknown


title: Factors Determining Quality of Life Related to Respiratory Status According to Gender of COPD Patients Followed by a Pneumologist

acronym: VITALITE

summary: The purpose of this study is to evaluate with sufficient precision and according to gender the determining independent factors of quality of life related to respiratory status of patient with moderate to severe COPD.

status: Completed

study_type: Observational

time_perspective: Cross-Sectional

lead_sponsor: AstraZeneca

lead_sponsor_type: industriel

status_simplified: Completed


title: Impact of the Use of a Computerized Protocol for Glucose Control Named CGAOtm on the Outcome of Critically Ill Patients

acronym: CGAO-REA

summary: The aim of the study is to determine whether the use of the CGAOtm software is associated with a decrease in 90-day mortality when compared with the use of standard care methods for glucose control with target blood glucose levels inferior to 180 mg/dl. The CGAOtm software is designed to assist physicians and nurses in achieving tight glucose control (defined by a target for blood glucose levels between 80 and 110 mg/dl) in critically ill patients.

ReferenceCitation: Carli P, Martin C. [Impact of Nice-Sugar: is there a need for another study on intensive glucose control in ICU?]. Ann Fr Anesth Reanim. 2009 Jun;28(6):519-21. doi: 10.1016/j.annfar.2009.05.002. Epub 2009 Jun 4. French.

ReferenceCitation: Guerrini A; Roudillon G; Gontier O; Rebaï L; Isorni MA; Mutinelli-Szymanski P; Sorine M; Kalfon P. High glycemic variability induced by inappropriate algorithms for intensive insulinotherapy: the example of the NICE-SUGAR study. Abstract award winners: The best pre-selected abstracts of the 22th Annual Congress of the European Society of Intensive Care Medicine, 11-14 October 2009, Vienna, Austria. Intensive Care Med. 2009 Sep;35 Suppl 1:S111.

ReferenceCitation: Gontier O; Hamrouni M; Lherm T; Monchamps G; Ouchenir A; Kalfon P. The CGAO software improves glycaemic control in intensive care patients without increasing the incidence of severe hypoglycaemia nor the nurse workload. Abstracts of the 21th Annual Congress of the European Society of Intensive Care Medicine, 21-24 September 2007, Lisbon, Portugal. Intensive Care Med. 2008 Sep;34 Suppl 2:S220.

ReferenceCitation: Abstracts of the 20th Annual Congress of the European Society of Intensive Care Medicine, 7-10 October 2007, Berlin, Germany. Intensive Care Med. 2007 Sep;33 Suppl 2:S5-271.

ReferenceType: derived

ReferenceCitation: Kalfon P, Le Manach Y, Ichai C, Bréchot N, Cinotti R, Dequin PF, Riu-Poulenc B, Montravers P, Annane D, Dupont H, Sorine M, Riou B; CGAO-REA Study Group. Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients. Crit Care. 2015 Apr 8;19:153. doi: 10.1186/s13054-015-0851-7.

ReferenceCitation: Kalfon P, Giraudeau B, Ichai C, Guerrini A, Brechot N, Cinotti R, Dequin PF, Riu-Poulenc B, Montravers P, Annane D, Dupont H, Sorine M, Riou B; CGAO-REA Study Group. Tight computerized versus conventional glucose control in the ICU: a randomized controlled trial. Intensive Care Med. 2014 Feb;40(2):171-181. doi: 10.1007/s00134-013-3189-0. Epub 2014 Jan 14.

lead_sponsor: Centre Hospitalier of Chartres

location_facility: Centre Hospitalier Départemental Les Oudairies

location_facility: CHU de Bordeaux - Groupe Hospitalier Sud, Hôpital Haut Lévêque

intervention_type: Device


title: Comparative Double Blind Placebo Controlled Clinical Study on Tocilizumab Rapid Efficacy on Patients Relief in rheumatoïd Arthritis With an Inadequate Response to DMARDs or Anti TNF :TORPEDO

summary: This study will assess the onset and maintenance of effect of tocilizumab on relief in patients with active moderate or severe rheumatoid arthritis who have had an inadequate response to DMARDs or anti-TNF. For the first, double-blind, part of the study patients will be randomized to receive an iv infusion of either 8mg/kg tocilizumab or placebo. After 4 weeks this will be followed by 11 months treatment with tocilizumab 8mg/kg iv infusion every 4 weeks. Methotrexate or DMARD therapy will be continued throughout study treatment. Target sample size is >100.

lead_sponsor: Hoffmann-La Roche


title: Phase III Study Comparing Irradiation at a Dose of 80 Gy to Irradiation at 70 Gy in Unfavorable Prostate Cancers Associated With Prolonged Hormonal Therapy

summary:
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. It is not yet known which dose of radiation therapy is more effective in treating patients with prostate cancer.

PURPOSE: This randomized phase III trial is comparing two radiation therapy regimens in treating patients with prostate cancer receiving hormone therapy.

study_start_date_type: Actual

study_completion_date_type: Anticipated

enrollment_type: Anticipated

ipd_sharing: No

ipd_sharing_description: Individual Participant Data will not be shared at an individual level. Those data will be part of the study database including all enrolled patients.

lead_sponsor: UNICANCER

location_facility: Institut de Cancérologie de l'Ouest Paul Papin

location_facility: Centre de Cancérologie du Grand Montpellier

location_facility: Institut de Cancérologie LUCIEN NEUWIRTH

intervention_type: Radiation

status_simplified: Ongoing


title: Open-label Study of Bevacizumab Maintenance Therapy (AVASTIN®) With or Without Pemetrexed After First-line Chemotherapy With Bevacizumab-cisplatin-pemetrexed in Patients With Advanced, Metastatic or Recurrent Non-squamous Non-small Cell Lung Cancer (NSCLC)

summary: This open-label study will assess the efficacy and safety of Avastin with or without pemetrexed as maintenance therapy in patients with advanced, metastatic or recurrent non-small cell lung cancer. In Part 1, patients will receive 4 cycles of treatment with Avastin (7.5mg/kg iv) plus cisplatin (75mg/m2 iv) plus pemetrexed (500mg/m2 iv) on day 1 of each 3-week cycle. In Part 2, patients responding to treatment will be randomized to receive further treatment cycles of Avastin (7.5mg/kg iv every 3 weeks) with or without pemetrexed (500mg/m2 iv every 3 weeks). Anticipated time on study treatment is until disease progression. Target sample size is <500 individuals.

ReferenceCitation: Barlesi F, Scherpereel A, Rittmeyer A, Pazzola A, Ferrer Tur N, Kim JH, Ahn MJ, Aerts JG, Gorbunova V, Vikström A, Wong EK, Perez-Moreno P, Mitchell L, Groen HJ. Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089). J Clin Oncol. 2013 Aug 20;31(24):3004-11. doi: 10.1200/JCO.2012.42.3749. Epub 2013 Jul 8.

location_country:
Spain
Italy
Greece
Netherlands
Russian Federation
Switzerland
Sweden
Korea, Republic of
France
Turkey
Germany
United Arab Emirates


intervention_type: Biological

title: Phase II Nonrandomized Multicenter Study of the Impact of Radiochemotherapy (65 Gy + Cisplatin + 5FU) Combined With Cetuximab in Patients Presenting With Locally Advanced Anal Cancer

type: EudraCT Number

source: euctr

location_facility: Centre Hospital Regional Universitaire de Limoges

location_facility: Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle

summary:
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving radiation therapy together with combination chemotherapy and cetuximab may kill more tumor cells.

PURPOSE: This phase II trial is studying giving radiation therapy together with cisplatin, fluorouracil, and cetuximab to see how well it works in treating patients with locally advanced anal cancer.


title: Multicenter Phase III Randomized Study of FOLFIRI Plus Bevacizumab Following or Not by a Maintenance Therapy With Bevacizumab in Patients With Non-Pretreated Metastatic Colorectal Cancer

summary:
RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of colorectal cancer by blocking blood flow to the tumor. It is not yet known whether giving more than one drug (combination chemotherapy) is more effective when given with or without bevacizumab in treating patients with metastatic colorectal cancer.

PURPOSE: This randomized phase III trial is studying giving combination chemotherapy with or without bevacizumab to see how well it works in treating patients with metastatic colorectal cancer.

ReferenceCitation: Aparicio T, Linot B, Le Malicot K, Bouché O, Boige V, François E, Ghiringhelli F, Legoux JL, Ben Abdelghani M, Phelip JM, Faroux R, Dahan L, Taieb J, Bedenne L. FOLFIRI+bevacizumab induction chemotherapy followed by bevacizumab or observation in metastatic colorectal cancer, a phase III trial (PRODIGE 9--FFCD 0802). Dig Liver Dis. 2015 Apr;47(4):271-2. doi: 10.1016/j.dld.2015.01.146. Epub 2015 Jan 20.

ReferenceType: result

ReferenceCitation: Aparicio T, Ghiringhelli F, Boige V, Le Malicot K, Taieb J, Bouché O, Phelip JM, François E, Borel C, Faroux R, Dahan L, Jacquot S, Genet D, Khemissa F, Suc E, Desseigne F, Texereau P, Lepage C, Bennouna J; PRODIGE 9 Investigators. Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic Colorectal Cancer: A Randomized Phase III Trial (PRODIGE 9). J Clin Oncol. 2018 Mar 1;36(7):674-681. doi: 10.1200/JCO.2017.75.2931. Epub 2018 Jan 18.

ReferenceCitation: Aparicio T, Bennouna J, Le Malicot K, Boige V, Taieb J, Bouché O, Phelip JM, François E, Borel C, Faroux R, Dahan L, Bachet JB, Egreteau J, Kaminsky MC, Gornet JM, Cojocarasu O, Gasmi M, Guerin-Meyer V, Lepage C, Ghiringhelli F; for PRODIGE investigators/collaborators. Predictive factors for early progression during induction chemotherapy and chemotherapy-free interval: analysis from PRODIGE 9 trial. Br J Cancer. 2020 Mar;122(7):957-962. doi: 10.1038/s41416-020-0735-8. Epub 2020 Feb 4.

ReferenceCitation: Guilloteau A, Abrahamowicz M, Boussari O, Jooste V, Aparicio T, Quantin C, Le Malicot K, Binquet C. Impact of time-varying cumulative bevacizumab exposures on survival: re-analysis of data from randomized clinical trial in patients with metastatic colo-rectal cancer. BMC Med Res Methodol. 2021 Jan 9;21(1):14. doi: 10.1186/s12874-020-01202-9.

ReferenceCitation: Dohan A, Gallix B, Guiu B, Le Malicot K, Reinhold C, Soyer P, Bennouna J, Ghiringhelli F, Barbier E, Boige V, Taieb J, Bouché O, François E, Phelip JM, Borel C, Faroux R, Seitz JF, Jacquot S, Ben Abdelghani M, Khemissa-Akouz F, Genet D, Jouve JL, Rinaldi Y, Desseigne F, Texereau P, Suc E, Lepage C, Aparicio T, Hoeffel C; PRODIGE 9 Investigators and PRODIGE 20 Investigators. Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab. Gut. 2020 Mar;69(3):531-539. doi: 10.1136/gutjnl-2018-316407. Epub 2019 May 17.

lead_sponsor: Federation Francophone de Cancerologie Digestive

location_facility: Clinique Valdegour, Centre ONCOGARD - Institut de Cancérologie du Gard

location_facility: Centre Radiothérapie et Oncologie de Moyenne Garonne


title: A Randomized Phase II Study of Clofarabine / Intermediate-Dose Cytarabine (CLARA)Versus High-Dose Cytarabine (HDAC) as Consolidation in Younger Patients With Newly-Diagnosed Acute Myeloid Leukemia (AML).

acronym: CLARA

summary:
This study is a phase II randomized multicenter study. Patients will be enrolled at time of diagnosis and will receive one or two cycles of induction chemotherapy. Patients, without indication of intensification by allogeneic stem cell transplantation and/or without HLA (Human Leukocyte Antigen)-compatible donor, who attain a CR after one or two cycles of induction chemotherapy, will be eligible for the study Clofarabine / Intermediate-Dose Cytarabine (CLARA)versus High-Dose Cytarabine (HDAC)and will be randomized between 3 courses of CLARA chemotherapy and 3 courses of HDAC chemotherapy as consolidation.

We will compare efficacy and toxicity among the two arms.

ReferenceCitation: Michallet M, Sobh M, Morisset S, Deloire A, Raffoux E, de Botton S, Caillot D, Chantepie S, Girault S, Berthon C, Bertoli S, Lepretre S, Leguay T, Castaigne S, Marolleau JP, Pautas C, Malfuson JV, Veyn N, Braun T, Gastaud L, Suarez F, Schmidt A, Gressin R, Bonmati C, Celli-Lebras K, El-Hamri M, Ribaud P, Dombret H, Thomas X, Bergeron A. Antifungal Prophylaxis in AML Patients Receiving Intensive Induction Chemotherapy: A Prospective Observational Study From the Acute Leukaemia French Association (ALFA) Group. Clin Lymphoma Myeloma Leuk. 2022 May;22(5):311-318. doi: 10.1016/j.clml.2021.10.011. Epub 2021 Oct 25.

ReferenceCitation: Fenwarth L, Thomas X, de Botton S, Duployez N, Bourhis JH, Lesieur A, Fortin G, Meslin PA, Yakoub-Agha I, Sujobert P, Dumas PY, Récher C, Lebon D, Berthon C, Michallet M, Pigneux A, Nguyen S, Chantepie S, Vey N, Raffoux E, Celli-Lebras K, Gardin C, Lambert J, Malfuson JV, Caillot D, Maury S, Ducourneau B, Turlure P, Lemasle E, Pautas C, Chevret S, Terré C, Boissel N, Socié G, Dombret H, Preudhomme C, Itzykson R. A personalized approach to guide allogeneic stem cell transplantation in younger adults with acute myeloid leukemia. Blood. 2021 Jan 28;137(4):524-532. doi: 10.1182/blood.2020005524.

lead_sponsor: Hospices Civils de Lyon

location_facility: Centre Hospitalier Regional et Universitaire d'Angers

location_facility: Hospices Civils de Lyon - Centre Hospitalier Lyon Sud


acronym: CPC

title: Randomized Phase II-III Study of Bevacizumab 7,5 mg/kg in Combination With Chemotherapy Versus Chemotherapy in Extensive-Disease Small-Cell Lung Cancer After Response to Chemotherapy : PCDE (cisPlatin - Cyclophosphamide - epiDoxorubicin - Etoposide) or PE (cisPlatin - Etoposide)

lead_sponsor: Intergroupe Francophone de Cancerologie Thoracique

ReferenceCitation: Pujol JL, Breton JL, Gervais R, Tanguy ML, Quoix E, David P, Janicot H, Westeel V, Gameroff S, Genève J, Maraninchi D. Phase III double-blind, placebo-controlled study of thalidomide in extensive-disease small-cell lung cancer after response to chemotherapy: an intergroup study FNCLCC cleo04 IFCT 00-01. J Clin Oncol. 2007 Sep 1;25(25):3945-51.

ReferenceCitation: Pujol JL, Daurès JP, Rivière A, Quoix E, Westeel V, Quantin X, Breton JL, Lemarié E, Poudenx M, Milleron B, Moro D, Debieuvre D, Le Chevalier T. Etoposide plus cisplatin with or without the combination of 4'-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: a French Federation of Cancer Institutes multicenter phase III randomized study. J Natl Cancer Inst. 2001 Feb 21;93(4):300-8.

ReferenceCitation: Horn L, Dahlberg SE, Sandler AB, Dowlati A, Moore DF, Murren JR, Schiller JH. Phase II study of cisplatin plus etoposide and bevacizumab for previously untreated, extensive-stage small-cell lung cancer: Eastern Cooperative Oncology Group Study E3501. J Clin Oncol. 2009 Dec 10;27(35):6006-11. doi: 10.1200/JCO.2009.23.7545. Epub 2009 Oct 13.

ReferenceCitation: Pujol JL, Lavole A, Quoix E, Molinier O, Souquet PJ, Barlesi F, Le Caer H, Moro-Sibilot D, Fournel P, Oster JP, Chatellain P, Barre P, Jeannin G, Mourlanette P, Derollez M, Herman D, Renault A, Dayen C, Lamy PJ, Langlais A, Morin F, Zalcman G; French Cooperative Thoracic Intergroup (IFCT). Randomized phase II-III study of bevacizumab in combination with chemotherapy in previously untreated extensive small-cell lung cancer: results from the IFCT-0802 trial†. Ann Oncol. 2015 May;26(5):908-914. doi: 10.1093/annonc/mdv065. Epub 2015 Feb 16.

ReferenceCitation: Negre E, Coffy A, Langlais A, Daures JP, Lavole A, Quoix E, Molinier O, Greillier L, Audigier-Valette C, Moro-Sibilot D, Westeel V, Morin F, Roch B, Pujol JL. Development and Validation of a Simplified Prognostic Score in SCLC. JTO Clin Res Rep. 2020 Feb 12;1(1):100016. doi: 10.1016/j.jtocrr.2020.100016. eCollection 2020 Mar.

location_facility:
Toulon - HIA
Neuilly - Hôpital Américain de Paris
Orléans - CH
CHU - Pneumologie
Verdun - CHG
CH
APHM - Hôpital Sainte Marguerite
Centre Hospitalier - Pneumologie
Dijon - CAC
CH - Compiègne
Meaux - CH
APHP - Saint-Antoine - pneumologie
Chalons-en-Champagne - CH
Montpellier - CHRU
Créteil - CHI
Saint Nazaire - Centre Etienne Dolet
Saint Quentin - CH
CHU Grenoble - pneumologie
Mont de Marsan - CH
Saverne - CH
Tours - CHU
Nevers - CH
Nancy - CHU
Institut Gustave Roussy
Thonon les bains
Cahors - CH
Reims - CRLCC
Maubeuge - Polyclinique du Parc
Toulouse - Clinique Pasteur
Angers - CHU
Saint Brieuc - CHG
Armentières - CH
Chartres - CH
Marseille - CRLCC
APHP - Hopital Tenon - Pneumologie
Hôpital Percy-Armées - Pneumologie
Mulhouse - CH
Saint Priest en Jarez - ICL
CHU Toulouse - Pneumologie
Reims - CHU
Pau - CH
Draguignan - CH
Chauny - CH
Vesoul - CHI
Clermont Ferrand - CHU
Nouvel Hopital Civil - Pneumologie
Senlis - CH
Annemasse - CH
Saint Omer - CHI
Metz - CHR
CHU Besancon - Pneumologie
Nice - CAC
Centre F. Baclesse
Colmar - CH
Dijon - CHU
HCL - Lyon Sud (Pneumologie)
Jonzac - CH
Harfleur - Clinique du Petit Colmoulins
Suresnes - Hopital Foch
Rouen - CHU

summary:
Despite the fact that a substantial response rate may be obtained in small-cell lung cancers (using double-drug chemotherapy: cisplatin-etoposide, PE), a cure remains an exception. More aggressive regimens remain controversial and recent attempts at increasing dose-intensity have been restricted to patients with a more favourable presentation.

Bevacizumab is a humanized monoclonal antibody which binds to VEGF (Vascular Endothelial Growth Factor). In association with double-drug standard chemotherapies, it has been proven that bevacizumab can improve survival of previously untreated advanced non-small-cell lung cancers (NSCLC), compared to chemotherapy without bevacizumab). Such promising effects on NSCLC deserve to be tested on small-cell lung cancers.

In this trial (IFCT-0802), standard chemotherapy (PCDE or PE) will be compared to experimental treatment (PCDE or PE + bevacizumab 7.5 mg/kg) for previously untreated SCLC patients.


ipd_sharing: Yes

acronym: Heads Up

title: A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis

lead_sponsor: AbbVie

ReferenceCitation: Blauvelt A, Teixeira HD, Simpson EL, Costanzo A, De Bruin-Weller M, Barbarot S, Prajapati VH, Lio P, Hu X, Wu T, Liu J, Ladizinski B, Chu AD, Eyerich K. Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial. JAMA Dermatol. 2021 Sep 1;157(9):1047-1055. doi: 10.1001/jamadermatol.2021.3023. Erratum In: JAMA Dermatol. 2022 Feb 1;158(2):219. JAMA Dermatol. 2022 Feb 1;158(2):219.

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

location_country:
Croatia
Spain
Italy
United Kingdom
Ukraine
United States
Czechia
Poland
Australia
Israel
Norway
Sweden
Malaysia
Singapore
Canada
Hungary
Germany
Taiwan
Ireland
New Zealand
Finland
France
Netherlands

location_facility: Integrated Clinical Research LLC /ID# 208831

location_facility: Somogy Megyei Kaposi Mor Oktat /ID# 210149

location_facility: Florida International Rsrch cr /ID# 211562

location_facility: Miami Dermatology and Laser Institute /ID# 212938

location_facility: Beacon Clinical Research, LLC /ID# 209280

location_facility: Hospital Universitario de Bellvitge /ID# 207063

location_facility: The Community Research of South Florida /ID# 211145

location_facility: Royal Alex Childrens County Hospital /ID# 209709

location_facility: Northwestern University Feinberg School of Medicine /ID# 208680

location_facility: Sugar Land Allergy, Asthma, and Immunology Center /ID# 211153

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 210893

location_facility: China Medical University Hosp /ID# 209770

location_facility: A.O. Policlinico Sant'Orsola Malpighi /ID# 209111

location_facility: Royalderm Agnieszka Nawrocka /ID# 211015

location_facility: National Taiwan University Hospital /ID# 208309

location_facility: Klinika Ambroziak Sp. z o.o. /ID# 207443

location_facility: Dr. Chih-ho Hong Medical Inc. /ID# 211032

location_facility: ClinicMed Daniluk, Nowak Sp.j. /ID# 211112

location_facility: Clinical Research Partners, LLC /ID# 212262

location_facility: Progressive Medical Research /ID# 211994

location_facility: Naftalan - Specijalna bolnica za medicinsku rehabilitaciju /ID# 209937

location_facility: Clinical Research Trials of Florida, Inc. /ID# 210751

location_facility: Universitair Medisch Centrum Groningen /ID# 208583

location_facility: ME "Rivne Regional Dermatology and Venereology Dispensary" of RRC /ID# 210434

location_facility: Georgia Pollens Clinical Research Centers, Inc /ID# 211092

location_facility: Klinicki bolnicki centar Zagreb /ID# 209976

location_facility: Keski-pohjanmaa Central Hospital /ID# 209534

location_facility: Szpital Uniwersytecki nr 1 im. dr. A. Jurasza w Bydgoszczy /ID# 211103

location_facility: Complejo Hospitalario Universitario de Pontevedra /ID# 207139

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 210632

location_facility: St Vincent's University Hosp /ID# 208441

location_facility: Medical Dermatology Associates of Chicago /ID# 210265

location_facility: Dermatology Research Associates /ID# 209097

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 209317

location_facility: University Hospital Waterford /ID# 208442

location_facility: Hospital Universitario Arnau Vilanova /ID# 207065

location_facility: Hautklinik Klinikum Darmstadt /ID# 210938

location_facility: IBD Center - IRCCS Istituto Clinico Humanitas /ID# 215726

location_facility: Universitair Medisch Centrum Utrecht /ID# 208579

location_facility: Hospital Pakar Sultanah Fatimah /ID# 210185

location_facility: Dermatology Research Institute Inc. /ID# 210942

location_facility: Medical University of South Carolina /ID# 211054

location_facility: DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 209935

location_facility: Meridian Clinical Research Dermatology /ID# 213251

location_facility: Dr. Wei Jing Loo Medicine Prof /ID# 211400

location_facility: Ospedale San Giovanni di Dio /ID# 209109

location_facility: Centre Hospitalier Universitaire de Nice - Hopital l'Archet 2 /ID# 213374

location_facility: Hospital Universitario y Politecnico La Fe /ID# 207064

location_facility: Kyiv City Clinical Skin and Venereal Hospital /ID# 210755

location_facility: Clinical Research Solutions, LLC /ID# 212542

location_facility: University of Arkansas for Medical Sciences /ID# 211688

location_facility: Hospital Universitario Dr. Negrin /ID# 208969

location_facility: Universitaetsklinikum Frankfurt /ID# 210934

location_facility: Pecsi Tudomanyegyetem Klinikai l.sz. Belgyogyaszati Klinika /ID# 210892

location_facility: Sneeze, Wheeze, & Itch Associates, LLC /ID# 212058

location_facility: Universitatsklinikum Munster /ID# 210935

location_facility: Cardiff & Vale University Health Board /ID# 209745

location_facility: Medizinische Hochschule Hannover /ID# 210939

location_facility: Epiphany Dermatology - Fort Worth /ID# 211187

location_facility: Niakosari Medicine Professional Corporation /ID# 211401

location_facility: Dartmouth-Hitchcock Medical Center /ID# 213727

location_facility: Forest Hills Dermatology Group /ID# 209249

location_facility: Oregon Health and Science University /ID# 208809

location_facility: Dre Angelique Gagne-Henley M.D. inc. /ID# 209498

location_facility: Military Hospital of Military-Medical Clinical Center of Southern Region /ID# 210435

location_facility: Wellington Hospital (Capital and Coast District Health Board) /ID# 215001

location_facility: Holdsworth House Medical Practice /ID# 214565

location_facility: Clinical Research Institute, Inc /ID# 210852

location_facility: California Allergy and Asthma Medical Group /ID# 213680

location_facility: Hopital Larrey - CHU de Toulouse /ID# 208976

location_facility: Guy's and St Thomas' NHS Found /ID# 208881

location_facility: Chung Shan Medical University /ID# 208311

location_facility: Nemocnice Jihlava, prispevkova organizace /ID# 209131

location_facility: Policlinico Univ Tor Vergata /ID# 209112

location_facility: Taipei Municipal Wan Fang Hospital /ID# 209987

location_facility: Oregon Medical Res Center PC /ID# 208807

location_facility: Karolinska University Hospital /ID# 207909

location_facility: Allergy, Asthma & Immunology Associates, PC /ID# 213481

location_facility: Universitetssykehuset N-Norge, Tromso /ID# 209103

location_facility: National University Hospital /ID# 208774

location_facility: Universitetssykehuset N-Norge, Harstad /ID# 209105

summary: This study will evaluate upadacitinib compared to dupilumab (Dupixent®) in adults with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.


title: A Multicenter, Randomized, Double-Blind Study to Evaluate Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Crohn's Disease and Evidence of Mucosal Ulceration

ReferenceCitation: D'Haens GR, Sandborn WJ, Loftus EV Jr, Hanauer SB, Schreiber S, Peyrin-Biroulet L, Panaccione R, Panés J, Baert F, Colombel JF, Ferrante M, Louis E, Armuzzi A, Zhou Q, Goteti VS, Mostafa NM, Doan TT, Petersson J, Finney-Hayward T, Song AP, Robinson AM, Danese S. Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results. Gastroenterology. 2022 Jun;162(7):1876-1890. doi: 10.1053/j.gastro.2022.01.044. Epub 2022 Feb 3.

ReferenceCitation: Greener T, Boland K, Milgrom R, Ben-Bassat O, Steinhart AH, Silverberg MS, Narula N. Higher adalimumab maintenance regimen is more effective than standard dose in anti-TNF experienced Crohn's disease patients. Eur J Gastroenterol Hepatol. 2021 Oct 1;33(10):1274-1279. doi: 10.1097/MEG.0000000000002250.

location_country:
Denmark
Poland
Romania
Spain
Italy
Austria
Netherlands
United Kingdom
Canada
Switzerland
Ukraine
Hungary
Puerto Rico
United States
France
Israel
Belgium
Germany
Slovakia
Czechia

location_facility: The Oregon Clinic, Gastroenterology - West /ID# 135272

location_facility: Policlinico Agostino Gemelli /ID# 127746

location_facility: Louisana Research Center, LLC /ID# 136749

location_facility: Kyiv City Clinical Hospital No.8 /ID# 126232

location_facility: Private Practice - Dr. Michael R. MroB Dipl. med. S. Schache /ID# 126257

location_facility: Gastroenterology Group Naples /ID# 122493

location_facility: Azienda Ospedaliera Spedali Civili /ID# 127744

location_facility: University of Calgary Cumming School of Medicine Adult Cystic Fibrosis Clinic /ID# 119017

location_facility: Winship Cancer Institute of Emory University /ID# 136851

location_facility: Hospital Clinico Universitario Lozano Blesa /ID# 126252

location_facility: Complejo Hospitalario Universitario de Pontevedra /ID# 138126

location_facility: Charlotte Gastroenterology and Hepatology, PLLC /ID# 119041

location_facility: Soroka University Medical Center /ID# 126243

location_facility: University Hospital Southampton NHS Fundation Trust /ID# 126225

location_facility: Gastroenterologicke centrum ASSIDUO a IBD centrum /ID# 126262

location_facility: Consultants for Clinical Res /ID# 119052

location_facility: IBD Center - IRCCS Istituto Clinico Humanitas /ID# 126226

location_facility: Northwestern University Feinberg School of Medicine /ID# 119043

location_facility: Erlanger Institute for Clinical Research /ID# 129008

location_facility: Public Institution 6th City Clinical Hospital /ID# 126236

location_facility: Azienda Ospedaliera di Padova /ID# 126267

location_facility: Birmingham Gastroenterology Associates O.C /ID# 137282

location_facility: Hospital Universitario de Girona Doctor Josep Trueta /ID# 137976

location_facility: CHU NANCY - Hopital Brabois Adultes /ID# 127742

location_facility: Texas Digestive Disease Consultants - Dallas /ID# 138121

location_facility: Hepato-Gastroenterologie HK s.r.o. /ID# 126269

location_facility: Kansas City Research Institute /ID# 119034

location_facility: Asklepios Westklinikum Hamburg /ID# 126275

location_facility: Universitatsklinikum Magdeburg /ID# 126256

location_facility: UOSD - Azienda Ospedaliera San Camillo Forlanini /ID# 127745

location_facility: Moore UC San Diego Cancer Center /ID# 119053

location_facility: Hospital Clinico Universitario San Carlos /ID# 126253

location_facility: Hospital Parc Tauli de Sabadell /ID# 138124

location_facility: Lviv Regional Clinical Hospital /ID# 126234

location_facility: Montreal General Hospital - McGill University Health Center /ID# 119025

location_facility: KO-Med Centra Kliniczne Pulawi /ID# 126278

location_facility: London Health Sciences Centre - University Hospital /ID# 119026

location_facility: Centrum Medyczne sw. Lukasza Sp. z o.o. /ID# 126271

location_facility: Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 129856

location_facility: The Royal Wolverhampton NHS Tr /ID# 126201

location_facility: NYU Langone Long Island Clinical Research Associates /ID# 119035

location_facility: Investigative Clinical Research /ID# 119033

location_facility: Vseobecna Nemocnica s poliklinikou Lucenec n.o. /ID# 127748

location_facility: Commonwealth Clinical Studies /ID# 136850

location_facility: Charite Universitaetsmedizin Berlin /ID# 126196

location_facility: Cabinet Medical Dr. Fratila SRL /ID# 126247

location_facility: Norfolk and Norwich Univ Hosp /ID# 126197

location_facility: Centre Hospitalier Universitaire de Grenoble - Hopital Michallon /ID# 126200

location_facility: Texas Digestive Disease Consultants - Southlake /ID# 137283

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 127743

location_facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 137735

location_facility: Ctr for Digest and Liver Dis /ID# 119040

location_facility: Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 126277

location_facility: Salvo-san Ciobanca SRL / Medicina Interna /ID# 126224

location_facility: Medizinische Universitat Wien /ID# 126279

location_facility: Froedtert Memorial Lutheran Hospital /ID# 119081

location_facility: Toronto Digestive Disease Asso /ID# 119019

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 140425

location_facility: CHU Amiens-Picardie Site Sud /ID# 126237

location_facility: Digestive Health Specialists of the Southeast /ID# 122483

location_facility: CHU de Saint-Etienne, Hopital Nord /ID# 134450

location_facility: Medizinische Universitat Innsbruck,Universitatsklinik fur Innere Medizin 1 /ID# 126249

location_facility: Rocky Mountain Gastroenterology /ID# 119038

location_facility: Minnesota Gastroenterology, P. A. /ID# 137280

location_facility: Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 119036

location_facility: State Institution L. T. Malaya Therapy National Institution of NAMS of Ukraine /ID# 127753

location_facility: Austin Institute for Clinical Research /ID# 125500

location_facility: Krankenhaus der Barmherzigen Bruder /ID# 126270

location_facility: University of Michigan Health Systems /ID# 119076

location_facility: Public Institution Kherson City Clinical Hospital named after le.le. Karabelesha /ID# 127754

location_facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 119042

location_facility: Winnipeg Regional Health Authority /ID# 119015

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 126221

location_facility: Israelitisches Krankenhaus Hamburg /ID# 136549

location_facility: Gastroenterology Institute, Division of Medicine /ID# 126245

location_facility: Shafran Gastroenterology Ctr /ID# 119057

location_facility: Hull University Teaching Hospitals NHS Trustust /ID# 126265

location_facility: Medical University of South Carolina /ID# 138122

location_facility: Gastroenterologicka ambulancia /ID# 137964

location_facility: Universitaetsklinikum Schleswig-Holstein /ID# 126260

location_facility: KH der Elisabethinen Linz GmbH /ID# 126280

location_facility: Centrum Endoskopii Zabiegowej /ID# 126272

location_facility: Carle Foundation Hospital Digestive Health Research Center /ID# 136008

location_facility: Nemocnice Ceske Budejovice a.s. /ID# 126266

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 119056

location_facility: Guy's and St Thomas' NHS Found /ID# 144366

location_facility: Wake Research Associates, LLC /ID# 119029

location_facility: Pecsi Tudomanyegyetem Klinikai l.sz. Belgyogyaszati Klinika /ID# 137895

location_facility: New River Valley Research Inst /ID# 127807

location_facility: Magyar Elhizastudomanyi KKft. /ID# 126276

location_facility: Academisch Medical center Amsterdam /ID# 126227

location_facility: Krajska zdravotni a.s. Masarykova nemocnice v Usti nad Labem o.z. /ID# 138331

location_facility: Centrum.Medyczne. Szpital Swietej Rodziny /ID# 137974

summary: This study will evaluate higher versus standard adalimumab dosing regimens for induction and maintenance therapy in subjects with moderately to severely active Crohn's Disease and evidence of mucosal ulceration.


title: A Phase 3, Multicenter, Randomized, Doubleblind, Placebo-controlled, Parallel Group Study, Followed by an Active-treatment Phase to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Subjects With Active Behcet's Disease

summary: The main objective of this study is to evaluate the efficacy and safety of apremilast in the treatment of oral ulcers in adults with active Behçet's disease (BD).

ReferenceCitation: Hatemi G, Mahr A, Takeno M, Kim D, Melikoğlu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y. Impact of apremilast on quality of life in Behçet's syndrome: analysis of the phase 3 RELIEF study. RMD Open. 2022 Jul;8(2). pii: e002235. doi: 10.1136/rmdopen-2022-002235.

ReferenceCitation: Hatemi G, Mahr A, Ishigatsubo Y, Song YW, Takeno M, Kim D, Melikoğlu M, Cheng S, McCue S, Paris M, Chen M, Yazici Y. Trial of Apremilast for Oral Ulcers in Behçet's Syndrome. N Engl J Med. 2019 Nov 14;381(20):1918-1928. doi: 10.1056/NEJMoa1816594.

ipd_sharing_description: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request

lead_sponsor: Amgen

location_country:
Greece
Italy
Lebanon
Korea, Republic of
United States
Israel
France
Turkey
Japan
Germany

location_facility: Japanese Red Cross Society Himeji Hospital

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Azienda Ospedaliero Universitaria Careggi

location_facility: Ippokratio General Hospital of Thessaloniki

location_facility: University of California Davis Medical Center

location_facility: University of Occupational and Environmentall Health

location_facility: American University of Beirut Medical Center

location_facility: Cukurova University Medical Faculty Balcali Hospital

location_facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi

location_facility: University of Pennsylvania Health Systems

location_facility: Arizona Arthritis and Rheumatology Research, PLLC

location_facility: Medical Hospital of Tokyo Medical and Dental University

location_facility: St Marianna University School of Medicine Hospital

location_facility: Northwestern University Feinberg School of Medicine


title: Interventional, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Delayed-Start Study to Evaluate the Efficacy and Safety of Eptinezumab in Patients With Episodic Cluster Headache

acronym: ALLEVIATE

summary: The purpose of this study is to evaluate the efficacy of eptinezumab in participants with episodic Cluster Headache (eCH)

status: Recruiting

lead_sponsor: H. Lundbeck A/S

location_country:
Denmark
Portugal
Spain
Greece
Georgia
Estonia
Italy
Finland
Netherlands
Russian Federation
United Kingdom
Sweden
United States
France
Norway
Belgium
Japan
Germany
Czechia

location_facility: City Hospital No. 33 of the Leninsky District of the city of Nizhny Novgorod

location_facility: Centre Hospitalier Universitaire de Saint-Étienne

location_facility: Perm State Medical University named after E. A. Wagner of the Ministry of Healthcare of the Russi...

location_facility: Froedtert and Medical College of Wisconsin

location_facility: Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari

location_facility: Hospital Clínico Universitario de Valencia

location_facility: Euromedica General Clinic - Thessaloniki

location_facility: Fondazione Mondino - Istituto Neurologico Nazionale a Carattere Scientifico IRCCS

location_facility: Northern Care Alliance NHS Foundation Trust

location_facility: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Fondazione Istituto Neurologico Car...

location_facility: Centro Hospitalar Universitario Lisboa Norte - Hospital De Santa Maria

location_facility: General Hospital of Patras Agios Andreas

location_facility: IRCCS Istituto Delle Scienze Neurologiche di Bologna

location_facility: Praxis für Neurologie, Psychosomatik, Nervenheilkunde, Psychotherapie und Spezielle Schmerztherapie

location_facility: Cleveland Clinic - Neurological Institute

location_facility: Universitatsklinikum Carl Gustav Carus Dresden

location_facility: Azienda Ospedaliero - Universitaria di Modena

location_facility: Ospedale Molinette - Clinica Neurologica II - Centro Cefalee

location_facility: Thomas Jefferson University Hospital - Center City Campus

location_facility: Eginition University - General Hospital of Athens

location_facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Michigan Headache and Neurological Institute

location_facility: Hospital Clinico Universitario Lozano Blesa

location_facility: Centre Hospitalier Chretien - Clinique MontLégia

location_facility: Neurology Colorado - Denver Advanced Neurological Evaluation and Treatment Center

location_facility: Hospitalsenhed Midt og Regionshospitalet Viborg

location_facility: Keck School of Medicine of the University of Southern California

location_facility: The Ohio State University Wexner Medical Center

location_facility: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - San Raffaele Pisana

location_facility: Hospital Universitari i Politècnic La Fe

location_facility: New England Institute for Neurology and Headache

location_facility: Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli

location_facility: Azienda Ospedaliero - Universitaria Careggi

location_facility: Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan

location_facility: First Moscow State Medical University named after I.M. Sechenov

location_facility: LLC Scientific and Practical Medical Center Innovation and Health

location_facility: Archangel Saint Michael Multiprofile Clinical Hospital

location_facility: King's College Hospital NHS Foundation Trust

location_facility: Saint Olavs Hospital - Universitetssykehuset I Trondheim

location_facility: Hospital Clínico Universitario de Valladolid

location_facility: Simon Khechinashvili University Hospital


title: Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)

summary: Novartis has set up this global Multiple Patient Program (MPP) treatment plan to provide access to life-saving treatment with LCZ696 for patients that were not previously exposed to LCZ696 but have no other option to receive LCZ696 in their country prior to market authorization OR commercial availability, based on local regulatory and legal requirements.

status: No longer available

study_type: Expanded Access

lead_sponsor: Novartis Pharmaceuticals

location_country:
Croatia
Brazil
Slovenia
Greece
Austria
Australia
Ireland
Lebanon
Spain
Switzerland
United States
France
Malta
Panama
Philippines
Germany
Cyprus
United Arab Emirates


title: VERDICT: In actiVE Ulcerative Colitis, a RanDomIzed Controlled Trial for Determination of the Optimal Treatment Target

acronym: VERDICT

summary:
Disease activity and response to therapy in ulcerative colitis (UC) can be assessed by a range of endpoints including symptoms, endoscopic mucosal activity, histological disease activity, and biomarkers. This study aims to determine the optimal treatment target, which is a research priority for the management of UC both to inform clinical practice and to help inform regulatory endpoints and targets for drug development.

Participants with active UC will be randomized in a 2:3:5 ratio to 1 of 3 groups, each with a different treatment target. Treatment targets will be defined as:

Group 1: corticosteroid-free symptomatic remission
Group 2: corticosteroid-free endoscopic + symptomatic remission
Group 3: corticosteroid-free histological + endoscopic + symptomatic remission

ipd_sharing: Undecided

lead_sponsor: Alimentiv Inc.

location_country:
Poland
United Kingdom
Canada
Ukraine
United States
France
Belgium
Netherlands

location_facility: Huron Gastroenterology Associates - Center for Digestive Care

location_facility: Oddział Gastroenterologiczny SP ZOZ w Łęcznej

location_facility: Barts Health NHS Trust / Whipps Cross University Hospital

location_facility: London Health Sciences Centre - University Campus

location_facility: Vinnytsia City Clinical Hospital #1, Dept of Gastroenterology

location_facility: Ternopil City Communal Emergency Medical Care Hosp

location_facility: Icahn School of Medicine at Mt Sinai Hospital

location_facility: CHU de Bordeaux - Hopital Haut Leveque - Groupe Hospitalier Sud

location_facility: City Clinical Hospital #9 Dept of Gastrosurgery SI Zaporizhzhia MA of PGE of MoHU

location_facility: Radboud University Nijmegen Medical Centre

location_facility: Szpital Miejski Sw. Jana Pawla II w Elblagu

location_facility: Vinnytsia M.I. Pyrohov Regional Clinical Hospital

location_facility: Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszcz

location_facility: UZ Leuven - University Hospital Gasthuisberg

location_facility: Asheville Gastroenterology Associates, PA

location_facility: Toronto Immune and Digestive Health Institute (TIDHI)

location_facility: Amsterdam UMC - Academisch Medisch Centrum


title: A Phase 1/2 Study on the Safety of Rovalpituzumab Tesirine Administered in Combination With Nivolumab or Nivolumab and Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer

summary: The purpose of this study is to assess the safety and efficacy of rovalpituzumab tesirine administered in combination with nivolumab or nivolumab and ipilimumab in participants with extensive-stage small cell lung cancer (SCLC).

design_allocation: Non-Randomized

location_country:
Spain
Italy
United States
France
Germany

location_facility: Hospital Universitario Madrid /ID# 165163

location_facility: Hospital Genl Gregorio Maranon /ID# 165162

location_facility: Centro di Riferimento Oncologi /ID# 165174

location_facility: Medical University of South Carolina /ID# 161007

location_facility: University of Wisconsin Clinic /ID# 161013

location_facility: The University of Kansas Clini /ID# 162915

location_facility: University Cancer & Blood Cent /ID# 161028

location_facility: Rutgers Cancer Institute of NJ /ID# 161032

location_facility: Istituto Europeo di Oncologia /ID# 165175

location_facility: Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele /ID# 165178

location_facility: Lungenfachklinik Immenhausen /ID# 165181

location_facility: Clinica Universitar de Navarra - Pamplona /ID# 165165

location_facility: Oregon Health and Science University /ID# 161029

location_facility: CHRU de Brest - Hospital Morva /ID# 165170

location_facility: CHU de Besancon - Jean Minjoz /ID# 165173

location_facility: Washington University-School of Medicine /ID# 161011

location_facility: Asklepios Fachkliniken M. Gaut /ID# 165183

location_facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 165164

location_facility: Vanderbilt University Med Ctr /ID# 162916

location_facility: Duke University Medical Center /ID# 161009

location_facility: Memorial Sloan Kettering Cancer Center /ID# 161010


title: A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

summary: This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

location_country:
Croatia
Serbia
Spain
Italy
United Kingdom
Lithuania
Ukraine
United States
Belgium
Japan
South Africa
Czechia
Poland
Portugal
Austria
Australia
Russian Federation
Argentina
Puerto Rico
Israel
Turkey
Mexico
Norway
Malaysia
Singapore
Sweden
Slovakia
Bosnia and Herzegovina
Brazil
Canada
Switzerland
Hungary
China
Germany
Taiwan
Belarus
Greece
Ireland
Estonia
Latvia
Finland
Korea, Republic of
France
Chile
Colombia
Netherlands

location_facility: Nagoya City University Hospital /ID# 151949

location_facility: CHA University Bundang Medical Center /ID# 161567

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705

location_facility: University of Iowa Hospitals and Clinics /ID# 157059

location_facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 217659

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079

location_facility: Southern Star Research Institute, LLC /ID# 169397

location_facility: Duplicate_Helsinki Univ Central Hospital /ID# 154283

location_facility: Gastroenterology Associates, P.A. of Greenville /ID# 150557

location_facility: Carl R. Meisner Medical Clinic /ID# 171270

location_facility: AGA Clinical Research Associates, LLC /ID# 153048

location_facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523

location_facility: West Central Gastroenterology /ID# 155242

location_facility: National Cheng Kung University Hospital /ID# 151751

location_facility: Asahikawa Medical University Hospital /ID# 170281

location_facility: Morales Vargas Centro de Investigacion S.C. /ID# 211327

location_facility: Lviv Regional Clinical Hospital /ID# 150508

location_facility: Texas Digestive Disease Consultants /ID# 209949

location_facility: Yonsei University Health System Severance Hospital /ID# 161566

location_facility: Centrum Medyczne Reuma Park w Warszawie /ID# 150624

location_facility: University of Maryland Med Ctr /ID# 150529

location_facility: General Hospital of Thessaloniki Hippokrateio /ID# 209522

location_facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697

location_facility: United Medical Doctors - Murrieta /ID# 151213

location_facility: Massachusetts General Hospital /ID# 165678

location_facility: Atrium Health Carolinas Medical Center /ID# 157060

location_facility: Delsol Research Management, Ll /Id# 170130

location_facility: Soroka University Medical Center /ID# 156562

location_facility: Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491

location_facility: Hospital Nossa Senhora das Graças /ID# 152488

location_facility: Duplicate_NW State Medical Univ na Mechn /ID# 169332

location_facility: Premier Medical Group - GI Division /ID# 153366

location_facility: Richmond University Medical Center /ID# 201860

location_facility: General Hospital of Athens Laiko /ID# 208672

location_facility: Taipei Veterans General Hosp /ID# 151750

location_facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733

location_facility: Virginia Mason Medical Center /ID# 153030

location_facility: Klinicki bolnicki centar Zagreb /ID# 150262

location_facility: The First Affiliated Hospital, Sun Yat-sen University /ID# 150517

location_facility: Hospital de Clinicas de Porto Alegre /ID# 153745

location_facility: Erciyes University Medical Fac /ID# 150495

location_facility: Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407

location_facility: Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358

location_facility: Republican hospital named after V.A. Baranov /ID# 206508

location_facility: Clinical Center University of Sarajevo /ID# 150222

location_facility: Univ of California San Francis /ID# 164583

location_facility: East View Medical Research, LLC /ID# 171184

location_facility: University Clinical Hospital Mostar /ID# 150711

location_facility: Medical Research Center of CT /ID# 150534

location_facility: Duplicate_Marmara University Medical Fac /ID# 214573

location_facility: Wake Forest Baptist Medical Center /ID# 150528

location_facility: Hospital Universitario Reina Sofia /ID# 154031

location_facility: Hospital Britanico de Buenos Aires /ID# 209496

location_facility: Northwest Health Care Associates /ID# 151591

location_facility: Crystal Pharmacology Research /ID# 151848

location_facility: Immanuel Kant Baltic Federal University /ID# 202129

location_facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744

location_facility: Juntendo University Urayasu Hospital /ID# 208783

location_facility: Allen Whey Khye Lim Professional Corporation /ID# 211169

location_facility: Dayton Gastroenterology, Inc. /ID# 167632

location_facility: China Medical University Hospital /ID# 150600

location_facility: Gastro Health & Nutrition - Victoria /ID# 167764

location_facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 204777

location_facility: University General Hospital of Ioannina /ID# 164247

location_facility: Plains Clinical Research Center, LLC /ID# 170291

location_facility: National Hospital Organization Sendai Medical Center /ID# 209529

location_facility: University of Alberta - Zeidler Ledcor Centre /ID# 151824

location_facility: Revival Research Institute, LLC /ID# 207281

location_facility: Dartmouth-Hitchcock Medical Center /ID# 150566

location_facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 151619

location_facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726

location_facility: Radboud Universitair Medisch Centrum /ID# 151701

location_facility: Kyiv Municipal Clinical Hospital #18 /ID# 150505

location_facility: Bekes Megyei Kozponti Korhaz /ID# 151601

location_facility: Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502

location_facility: Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575

location_facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 150946

location_facility: Medizinische Universitaet Wien /ID# 150616

location_facility: Hometown Urgent Care and Resea /ID# 200066

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439

location_facility: Hayang University GuriHospital /ID# 150431

location_facility: Healthcare Research Consultant /ID# 163096

location_facility: Clinical Research Trials of Florida, Inc. /ID# 201791

location_facility: Yamagata University Hospital /ID# 171468

location_facility: Showa University Fujigaoka Hospital /ID# 208223

location_facility: Digestive Health Partners, P.A /ID# 167238

location_facility: Duplicate_CHU de Saint-Etienne, Hopital Nord /ID# 165756

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871

location_facility: Hospital Garcia de Orta, EPE /ID# 151622

location_facility: Centex Studies, Inc. - Houston /ID# 201217

location_facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 167954

location_facility: Hospital Clinic de Barcelona /ID# 150598

location_facility: University Hospitals Birmingham NHS Foundation Trust /ID# 150513

location_facility: Western Connecticut Medical Group /ID# 169211

location_facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 150463

location_facility: Yokohama City University Medical Center /ID# 169900

location_facility: Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731

location_facility: Kaiser Clinica e Hospital Dia /ID# 152491

location_facility: Aurora Medical Center - Grafto /ID# 151726

location_facility: NHS Greater Glasgow and Clyde /ID# 163788

location_facility: University General Hospital of Heraklion PA.G.N.I /ID# 150236

location_facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616

location_facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 171492

location_facility: Columbia Univ Medical Center /ID# 163409

location_facility: Moonshine Research Center, Inc /ID# 152534

location_facility: Medizinisches Versorgungszentrum Portal 10 /ID# 207136

location_facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812

location_facility: Duplicate_Shanghai Tenth People's Hospital /ID# 150522

location_facility: CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941

location_facility: Sapporo Medical University Hospital /ID# 206493

location_facility: Klaipeda University Hospital /ID# 163719

location_facility: Texas Digestive Disease Consultants /ID# 209806

location_facility: Omega Research Maitland, LLC /ID# 200271

location_facility: Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151845

location_facility: South Denver Gastroenterology /ID# 151224

location_facility: MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216302

location_facility: Tyler Research Institute, LLC /ID# 169147

location_facility: Huron Gastroenterology Assoc /ID# 152712

location_facility: Niigata University Medical & Dental Hospital /ID# 218050

location_facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 150421

location_facility: Baylor College of Medicine - Baylor Medical Center /ID# 150538

location_facility: Atlantic Gastroenterology Clinical Research /ID# 151901

location_facility: Tsujinaka Hospital Kashiwanoha /ID# 209572

location_facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 150424

location_facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886

location_facility: Nature Coast Clinical Research - Inverness /ID# 154070

location_facility: University Clinical Center Tuzla /ID# 150224

location_facility: Azienda Ospedaliera San Camillo Forlanini /ID# 151362

location_facility: Shengjing Hospital of China Medical University /ID# 166921

location_facility: ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605

location_facility: Hampshire Hospitals NHS Foundation Trust /ID# 150511

location_facility: Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399

location_facility: Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516

location_facility: Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730

location_facility: National Taiwan University Hospital /ID# 150604

location_facility: Universitaetsklinikum Tuebingen Medizinische Klinik /ID# 151698

location_facility: Minnesota Gastroenterology PA /ID# 151682

location_facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 170713

location_facility: Kanazawa University Hospital /ID# 207810

location_facility: Hospital Guillermo Grant Benavente de Concepción /ID# 212425

location_facility: Kitakyushu Municipal Med Ctr /ID# 152589

location_facility: Universitair Ziekenhuis Leuven /ID# 150468

location_facility: Theageneio Anticancer Hospital /ID# 164187

location_facility: University of Mississippi Medical Center /ID# 213140

location_facility: Universitatsklinikum Mannheim /ID# 150405

location_facility: Pusan National University Hospital /ID# 161569

location_facility: Hospital Universitario A Coruna - CHUAC /ID# 203912

location_facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 151620

location_facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420

location_facility: Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561

location_facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771

location_facility: Cotton-O'Neil Clinical Res Ctr /ID# 167183

location_facility: CCA Braga - Hospital de Braga /ID# 151617

location_facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158

location_facility: Ctr for Gastrointestinal Healt /ID# 153369

location_facility: Xiangya Hospital Central South University /ID# 167230

location_facility: Duplicate_Klinicki bolnicki centar Osijek /ID# 150229

location_facility: Centro Hospitalar de Entre Douro e Vouga /ID# 152336

location_facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334

location_facility: Gastroenterology Associates of Central Georgia, LLC /ID# 165783

location_facility: Markusovszky Egyetemi Oktatokorhaz /ID# 150410

location_facility: Toho University Sakura Medical Center /ID# 151935

location_facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101

location_facility: Hadassah Medical Center-Hebrew University /ID# 165119

location_facility: Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 152811

location_facility: East Tennessee Research Institute /ID# 203611

location_facility: Kitasato University Kitasato Institute Hospital /ID# 152687

location_facility: University Clinical Centre of the Republic of Srpska /ID# 150223

location_facility: University Clinical Center of Nis /ID# 151902

location_facility: St. Marianna University School of Medicine Hospital /ID# 209452

location_facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 217219

location_facility: MediSphere Medical Research Center /ID# 152080

location_facility: Hospital Universitario de San /ID# 155388

location_facility: CliniCore International, LLC /ID# 152078

location_facility: Hospital Universitario y Politecnico La Fe /ID# 150591

location_facility: Indianapolis Gastroenterology /ID# 162914

location_facility: Tokai University Hachioji Hospital /ID# 152584

location_facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673

location_facility: Slovak Research Center Team Me /ID# 150240

location_facility: Washington Gastroenterology Associates /ID# 163630

location_facility: Hospital Clinico Universidad De Los Andes /ID# 207427

location_facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 150627

location_facility: Clin Res Inst of Michigan, LLC /ID# 153031

location_facility: Advanced Research Institute, Inc /ID# 163093

location_facility: Faculdade de Medicina do ABC /ID# 152489

location_facility: Toyohashi Municipal Hospital /ID# 171470

location_facility: CB Flock Research Corporation /ID# 165986

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371

location_facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 151618

location_facility: Inselspital, Universitätsspital Bern /ID# 152602

location_facility: Atlanta Gastroenterology Spec /ID# 150565

location_facility: Umraniye Training and Res Hosp /ID# 163136

location_facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826

location_facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 165813

location_facility: CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 165749

location_facility: Klinicki bolnicki centar Zagreb /ID# 150715

location_facility: Washington University-School of Medicine /ID# 150537

location_facility: Hospital Clinico Universitario de Salamanca /ID# 150590

location_facility: Yeungnam University Medical Center /ID# 150432

location_facility: Yokkaichi Hazu Medical Center /ID# 214349

location_facility: Options Health Research, LLC /ID# 150569

location_facility: Nemocnice Pardubickeho kraje, a.s. /ID# 213541

location_facility: CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374

location_facility: St George's University Hospitals NHS Foundation Trust /ID# 208376

location_facility: The Sixth Affiliated Hosp Sun /ID# 150518

location_facility: Percuro Clinical Research, Ltd /ID# 150479

location_facility: Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265

location_facility: Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462

location_facility: Ishida Clinic of IBD and Gastroenterology /ID# 210118

location_facility: Sapporo Higashi Tokushukai Hospital /ID# 208495

location_facility: Next Innovative Clinical Research - Chicago /ID# 217323

location_facility: Universitair Medisch Centrum Utrecht /ID# 152776

location_facility: DiGiovanna Institute for Medical Education & Research /ID# 201534

location_facility: Hamamatsu University Hospital /ID# 205709

location_facility: Tokyo Women's Medical University Hospital /ID# 205978

location_facility: The Vancouver Clinic, INC. PS /ID# 162334

location_facility: Fukuoka University Chikushi Hospital /ID# 152627

location_facility: The Catholic University of Korea, ST. Vincent's Hospital /ID# 150434

location_facility: Akershus Universitetssykehus_MAIN /ID# 150622

location_facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 152492

location_facility: Inland Empire Clinical Trials, LLC /ID# 216163

location_facility: Ottawa Hospital Research Institute /ID# 151817

location_facility: Klinicki bolnicki centar Rijeka /ID# 150714

location_facility: Kazan State Medical University /ID# 166040

location_facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089

location_facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082

location_facility: St Vincent's University Hospital /ID# 150411

location_facility: National University Hospital /ID# 150583

location_facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629

location_facility: Vanderbilt University Medical Center /ID# 153364

location_facility: Vitebsk Regional Advanced Clin /ID# 169592

location_facility: University Clinical Centre of the Republic of Srpska /ID# 150712

location_facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 151615

location_facility: Ohio Clinical Research Partner /ID# 154074

location_facility: St.Luke's International Hospital /ID# 208075

location_facility: Consultants for Clinical Research /ID# 151683

location_facility: Gazi Universitesi Tip Fakultes /ID# 150493

location_facility: Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 150228

location_facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 150263

location_facility: Private Practice Dr MN Rajabally /ID# 155145

location_facility: West Tallinn Central Hospital /ID# 150490

location_facility: Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820

location_facility: Macquarie University Hospital /ID# 211953

location_facility: Clinical Hosp Center Zvezdara /ID# 150641

location_facility: Northwest Gastroenterology Clinic /ID# 152528

location_facility: CHU Montpellier - Hôpital Saint Eloi /ID# 200088

location_facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224

location_facility: Royal Victoria Hospital / McGill University Health Centre /ID# 170013

location_facility: NorthShore University HealthSystem /ID# 150570

location_facility: National Hospital Organization Mito Medical Center /ID# 152626

location_facility: Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 207052

location_facility: Iwate Medical University Uchimaru Medical Center /ID# 203412

location_facility: Duplicate_Stavropol State Medical Univ /ID# 150635

location_facility: National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711

location_facility: Louisana Research Center, LLC /ID# 150526

location_facility: Universitetssykehuset Nord-Norge /ID# 152836

location_facility: Royal Devon and Exeter NHS Trust Hospital /ID# 150510

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 152609

location_facility: East Tallinn Central Hospital /ID# 150488

location_facility: Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599

location_facility: Mautalen Salud e Investigacion /ID# 171174

location_facility: Utah Gastroenternology - St. Mark's Office /ID# 163097

location_facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487

location_facility: Yamanashi Prefectural Central Hospital /ID# 151909

location_facility: Center Hospital of the National Center for Global Health and Medicine /ID# 209533

location_facility: Universitatsklinikum Munster /ID# 150402

location_facility: Montefiore Medical Center - Moses Campus /ID# 150559

location_facility: Chung Shan Medical University Hospital /ID# 150603

location_facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406

location_facility: Hamilton Health Sciences - McMaster University Medical Centre /ID# 150477

location_facility: Osaka City University Hospital /ID# 152681

location_facility: Hospital Universitario Dr. Negrin /ID# 203965

location_facility: Fondazione PTV Policlinico Tor Vergata /ID# 150425

location_facility: Leids Universitair Medisch Centrum /ID# 152625

location_facility: Encore Borland-Groover Clinical Research /Id# 170913

location_facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823

location_facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313

location_facility: Hyogo College of Medicine College Hospital /Id# 152433

location_facility: InSite Digestive Health Care - Oxnard /ID# 163417

location_facility: Sahlgrenska University Hospital /ID# 152326

location_facility: Shoyukai Fujita Gastroenterological Hospital /ID# 216494

location_facility: Hospital Universitario La Paz /ID# 214541

location_facility: Atlantic Digestive Health Inst /ID# 150527

location_facility: Tianjin Medical University General Hospital /ID# 170605

location_facility: Toronto Digestive Disease Asso /ID# 150475

location_facility: St Vincent's Hospital Melbourne /ID# 152503

location_facility: Medical College of Wisconsin /ID# 151850

location_facility: Houma Digestive Health Special /ID# 151851

location_facility: Aichi Medical University Hospital /ID# 151994

location_facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869

location_facility: Velocity Clinical Research - Salt Lake City /ID# 163180

location_facility: Klinicki bolnicki centar Split /ID# 213989

location_facility: Duplicate_Vilnius University Hospital /ID# 164172

location_facility: Hospital Privado Univesitario /ID# 164186

location_facility: The First Hospital of Jilin University /ID# 210087

location_facility: Shimane University School of Medicine /ID# 208906

location_facility: Universal Axon Clinical Research /ID# 213463

location_facility: Lenasia Clinical Trial Centre /ID# 214361

location_facility: Pauls Stradins Clinical University Hospital /ID# 153183

location_facility: TX Clinical Research Institute /ID# 151528

location_facility: Japanese Red Cross Osaka Hospital /ID# 209477

location_facility: Tokyo Medical And Dental University Hospital /ID# 152017

location_facility: Great Lakes Medical Research, LLC /ID# 201773

location_facility: University Clinical Center Kragujevac /ID# 150644

location_facility: Chu de Nice-Hopital L'Archet Ii /Id# 152608

location_facility: Hospital Unversitario Marques de Valdecilla /ID# 216621

location_facility: Medical Center CONSILIUM MEDICAL /ID# 217448

location_facility: Saiseikai Fukuoka Genaral Hospital /ID# 209481

location_facility: Digestive Disease Specialists /ID# 201057

location_facility: West China Hospital, Sichuan University /ID# 167041

location_facility: Citrus Valley Gastroenterology /ID# 151915

location_facility: North Estonia Medical Centre /ID# 160871

location_facility: Clin Hosp Ctr Bezanijska Kosa /ID# 150640

location_facility: Agaplesion Markus Krankenhaus /ID# 161870

location_facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 150226

location_facility: Mentahaz Maganorvosi Kozpont /ID# 206977

location_facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634

location_facility: NYU Langone Long Island Clinical Research Association /ID# 155271

location_facility: Hospital Universitario Ramon y Cajal /ID# 171491

location_facility: University Clinical Center Serbia /ID# 150642

location_facility: Newport Huntington Medical Group /ID# 217006

location_facility: Hiroshima University Hospital /ID# 151952

location_facility: The First Affiliated Hospital of Nanchang University /ID# 212185

location_facility: Medical Center of the "Health /ID# 162501