title: A Long-term Follow-up of Adult Kidney and Liver Allograft Recipients Previously Enrolled Into a Tacrolimus (Advagraf) Trial. A Multicentre Non-interventional Post Authorization Study (PAS)

acronym: ADDRESS

summary: The purpose of this study is to evaluate the impact of Advagraf, prolonged-release, once daily tacrolimus formulation, on long-term graft survival in kidney and liver allograft recipients. This study will also evaluate the overall long-term impact of Advagraf on kidney and liver allograft recipients.

location_country:
Spain
Italy
United Kingdom
Romania
Belgium
Czechia
Poland
Portugal
Austria
Russian Federation
Sweden
Slovakia
Canada
Switzerland
Hungary
Germany
Belarus
Ireland
Latvia
Estonia
Finland
Korea, Republic of
France
Netherlands

location_facility:
Site RO40001
Site NL31001
Site DE49013
Site FR33003
Site CZ42004
Site IT39010
Site DE49017
Site ES34019
Site ES34014
Site FR33022
Site ES34007
Site DE49002
Site FR33008
Site DE49022
Site IT39002
Site BY37501
Site FR33007
Site RU70011
Site BE32009
Site IT39019
Site FR33002
Site CZ42002
Site IT39016
Site IE35301
Site IT39012
Site FR33018
Site FR33004
Site ES34016
Site FR33027
Site HU36003
Site BE32005
Site SE46002
Site RU70004
Site IT39008
Site IT39015
Site FR33024
Site ES34021
Site CZ42005
Site DE49016
Site IT39003
Site RU70010
Site SE46001
Site PL48004
Site BE32001
Site FR33023
Site FR33010
Site DE49004
Site IT39014
Site PL48005
Site FR33015
Site ES34009
Site PL48007
Site RU70013
Site FI35801
Site KR82001
Site FR33020
Site IT39001
Site ES34013
Site DE49001
Site KR82007
Site IT39013
Site FR33019
Site FI35802
Site KR82006
Site DE49027
Site FR33026
Site FR33029
Site ES34015
Site RU70002
Site IT39017
Site HU36001
Site GB44001
Site BE32002
Site IT39020
Site DE49005
Site DE49011
Site ES34010
Site IT39005
Site DE49025
Site FR33030
Site IT39009
Site PT35102
Site AT43003
Site FR33017
Site PL48006
Site SK42101
Site DE49006
Site FR33014
Site RO40003
Site RU70012
Site FR33011
Site GB44002
Site FR33032
Site ES34020
Site DE49014
Site BE32008
Site CZ42003
Site IT39006
Site FR33031
Site ES34011
Site DE49010
Site PL48003
Site SE46004
Site ES34001
Site PL48001
Site GB44003
Site BE32007
Site SK42102
Site RU70014
Site DE49015
Site RU70007
Site ES34003
Site CZ42006
Site AT43001
Site FR33012
Site EE37201
Site ES34006
Site CZ42001
Site RU70005
Site FR33028
Site IT39004
Site ES34004
Site HU36002
Site KR82005
Site AT43002
Site IT39011
Site CH41002
Site DE49008
Site ES34018
Site CA15001
Site FR33025
Site KR82002
Site FR33034
Site IT39021
Site FR33009
Site FR33001
Site ES34012
Site CA15003
Site BE32003
Site DE49030
Site DE49018
Site DE49019
Site ES34017
Site LV37101
Site ES34005


status: Completed

primary_purpose: Treatment

intervention_type: Drug

title: An Open-label, Multi-center, Three Arm Randomized Study to Investigate the Safety and Efficacy on Progression-free Survival of RO5072759 + Chlorambucil (GClb) Compared to Rituximab + Chlorambucil (RClb) or Chlorambucil (Clb) Alone in Previously Untreated CLL Patients With Comorbidities.

study_completion_date_type: Actual

lead_sponsor: Hoffmann-La Roche

source: euctr

design_allocation: Randomized

study_start_date_type: Actual

study_type: Interventional

ReferenceType: derived

ReferenceCitation: Dimier N, Delmar P, Ward C, Morariu-Zamfir R, Fingerle-Rowson G, Bahlo J, Fischer K, Eichhorst B, Goede V, van Dongen JJM, Ritgen M, Böttcher S, Langerak AW, Kneba M, Hallek M. A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL. Blood. 2018 Mar 1;131(9):955-962. doi: 10.1182/blood-2017-06-792333. Epub 2017 Dec 18.

enrollment_type: Actual

location_country:
Croatia
Spain
Italy
United Kingdom
United States
Romania
Czechia
Hong Kong
Austria
Australia
Russian Federation
Argentina
Mexico
Slovakia
Egypt
Brazil
Canada
Switzerland
Germany
Bulgaria
Denmark
Estonia
New Zealand
Thailand
France
Netherlands

summary: This open-label, randomized, 3-arm study will evaluate the efficacy and safety of (obinutuzumab) RO5072759 in combination with chlorambucil as compared to rituximab plus chlorambucil or chlorambucil alone in patients with previously untreated chronic lymphocytic leukemia (CLL). Patients will be randomized 2:2:1 to receive a maximum of six 28-day cycles of either RO5072759 (1000 mg intravenous (iv) infusion, on days 1, 8 and 15 of cycle 1 and day 1 of cycles 2-6) plus chlorambucil (0.5 mg/kg orally, days 1 and 15 of cycles 1-6), or rituximab (iv infusion day 1, 375 mg/m^2 cycle 1, 500 mg/m^2 cycles 2-6) plus chlorambucil, or chlorambucil alone. Anticipated time on study treatment is >6 months and follow-up for disease-progression and safety will be at least 5 years. In the US, this trial is sponsored/managed by Genentech.

lead_sponsor_type: industriel

status_simplified: Completed


ipd_sharing: No

status: Active, not recruiting

acronym: STIMULI

title: A Randomised Open-label Phase II Trial of Consolidation With Nivolumab and Ipilimumab in Limited-stage SCLC After Chemo-radiotherapy

study_completion_date_type: Anticipated

lead_sponsor: ETOP IBCSG Partners Foundation

type: EudraCT Number

type: Other Identifier

type: Registry Identifier

ReferenceType: background

ReferenceCitation: Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012 Jun 10;30(17):2046-54. doi: 10.1200/JCO.2011.38.4032. Epub 2012 Apr 30. Erratum in: J Clin Oncol. 2012 Oct 10;30(29):3654.

ReferenceCitation: Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol. 2013 Jan;24(1):75-83. doi: 10.1093/annonc/mds213. Epub 2012 Aug 2.

ReferenceCitation: Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, Wolchok JD, Clark JI, Sznol M, Logan TF, Richards J, Michener T, Balogh A, Heller KN, Hodi FS. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012 May;13(5):459-65. doi: 10.1016/S1470-2045(12)70090-6. Epub 2012 Mar 27.

location_country:
Spain
United Kingdom
Australia
Netherlands
Switzerland
France
Belgium
Germany

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: Hospital Universitario Central De Asturias

location_facility: Royal Brisbane and Women's Hospital (QLD)

location_facility: Hospital Clínico Universitario De Valencia

location_facility: Centre Hospitalier Universitaire de Montpellier

location_facility: Hospital Universitario Fundacion Jimenez Díaz

location_facility: University Hospital Gasthuisberg, KU Leuven

summary:
Despite the fact that the majority of the patients with limited disease SCLC will respond very well to the standard treatment, a great proportion will relapse within 12 - 24 months.

Several studies in patients with lung cancer suggested a possible favourable association between the increased presence of immunologically active cells in the tumour and survival. Nivolumab and ipilimumab are proteins, which help your immune system to attack and destroy cancer cells by your immune cells. Early clinical trials with nivolumab and ipilimumab have shown activity in a broad range of cancers, including SCLC.

The aim of the current study is to investigate the efficacy (how well the treatment works) and tolerability (how severe the side effects are) of the standard treatment (chemotherapy and radiotherapy) alone, compared with the standard treatment followed by nivolumab and ipilimumab in patients with limited SCLC.

status_simplified: Ongoing


title: A Randomised, Double-blind, Parallel Group, Placebo-controlled Multi-centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients With gBRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant Chemotherapy

acronym: OlympiA

summary: Olaparib treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy

ReferenceCitation: Perachino M, Poggio F, Arecco L, Blondeaux E, Spinaci S, Marrocco C, Levaggi A, Lambertini M. Update on Pregnancy Following Breast Cancer Diagnosis and Treatment. Cancer J. 2022 May-Jun 01;28(3):176-182. doi: 10.1097/PPO.0000000000000599. Review.

ReferenceCitation: Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. N Engl J Med. 2021 Jun 24;384(25):2394-2405. doi: 10.1056/NEJMoa2105215. Epub 2021 Jun 3.

ipd_sharing: Yes

ipd_sharing_description:
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

lead_sponsor: AstraZeneca

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Iceland
Japan
Poland
Portugal
Austria
Australia
Argentina
Puerto Rico
Israel
Sweden
Canada
Switzerland
Hungary
China
Germany
Taiwan
Korea, Republic of
France
Netherlands


acronym: OAK

title: A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Failure With Platinum Containing Chemotherapy

ReferenceCitation: Cortellini A, Ricciuti B, Borghaei H, Naqash AR, D'Alessio A, Fulgenzi CAM, Addeo A, Banna GL, Pinato DJ. Differential prognostic effect of systemic inflammation in patients with non-small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3 OAK trial. Cancer. 2022 Aug 15;128(16):3067-3079. doi: 10.1002/cncr.34348. Epub 2022 Jun 21.

ReferenceCitation: Gadgeel S, Hirsch FR, Kerr K, Barlesi F, Park K, Rittmeyer A, Zou W, Bhatia N, Koeppen H, Paul SM, Shames D, Yi J, Matheny C, Ballinger M, McCleland M, Gandara DR. Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non-Small Cell Lung Cancer: Results From the Randomized OAK Trial. Clin Lung Cancer. 2022 Jan;23(1):21-33. doi: 10.1016/j.cllc.2021.05.007. Epub 2021 May 30.

ReferenceCitation: Gandara D, Reck M, Moro-Sibilot D, Mazieres J, Gadgeel S, Morris S, Cardona A, Mendus D, Ballinger M, Rittmeyer A, Peters S. Fast progression in non-small cell lung cancer: results from the randomized phase III OAK study evaluating second-line atezolizumab versus docetaxel. J Immunother Cancer. 2021 Mar;9(3). pii: e001882. doi: 10.1136/jitc-2020-001882.

ReferenceCitation: Shemesh CS, Chan P, Legrand FA, Shames DS, Das Thakur M, Shi J, Bailey L, Vadhavkar S, He X, Zhang W, Bruno R. Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden. Pharmacol Res Perspect. 2020 Dec;8(6):e00685. doi: 10.1002/prp2.685.

ReferenceCitation: Chalabi M, Cardona A, Nagarkar DR, Dhawahir Scala A, Gandara DR, Rittmeyer A, Albert ML, Powles T, Kok M, Herrera FG; imCORE working group of early career investigators. Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials. Ann Oncol. 2020 Apr;31(4):525-531. doi: 10.1016/j.annonc.2020.01.006. Epub 2020 Jan 16.

ReferenceCitation: Morrissey KM, Marchand M, Patel H, Zhang R, Wu B, Phyllis Chan H, Mecke A, Girish S, Jin JY, Winter HR, Bruno R. Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting. Cancer Chemother Pharmacol. 2019 Dec;84(6):1257-1267. doi: 10.1007/s00280-019-03954-8. Epub 2019 Sep 21.

ReferenceCitation: Gadgeel SM, Lukas RV, Goldschmidt J, Conkling P, Park K, Cortinovis D, de Marinis F, Rittmeyer A, Patel JD, von Pawel J, O'Hear C, Lai C, Hu S, Ballinger M, Sandler A, Gandhi M, Fehrenbacher L. Atezolizumab in patients with advanced non-small cell lung cancer and history of asymptomatic, treated brain metastases: Exploratory analyses of the phase III OAK study. Lung Cancer. 2019 Feb;128:105-112. doi: 10.1016/j.lungcan.2018.12.017. Epub 2018 Dec 19.

ReferenceCitation: Bordoni R, Ciardiello F, von Pawel J, Cortinovis D, Karagiannis T, Ballinger M, Sandler A, Yu W, He P, Matheny C, Felizzi F, Rittmeyer A. Patient-Reported Outcomes in OAK: A Phase III Study of Atezolizumab Versus Docetaxel in Advanced Non-Small-cell Lung Cancer. Clin Lung Cancer. 2018 Sep;19(5):441-449.e4. doi: 10.1016/j.cllc.2018.05.011. Epub 2018 May 31.

ReferenceCitation: Hida T, Kaji R, Satouchi M, Ikeda N, Horiike A, Nokihara H, Seto T, Kawakami T, Nakagawa S, Kubo T. Atezolizumab in Japanese Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer: A Subgroup Analysis of the Phase 3 OAK Study. Clin Lung Cancer. 2018 Jul;19(4):e405-e415. doi: 10.1016/j.cllc.2018.01.004. Epub 2018 Feb 1.

ReferenceCitation: Rittmeyer A, Barlesi F, Waterkamp D, Park K, Ciardiello F, von Pawel J, Gadgeel SM, Hida T, Kowalski DM, Dols MC, Cortinovis DL, Leach J, Polikoff J, Barrios C, Kabbinavar F, Frontera OA, De Marinis F, Turna H, Lee JS, Ballinger M, Kowanetz M, He P, Chen DS, Sandler A, Gandara DR; OAK Study Group. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet. 2017 Jan 21;389(10066):255-265. doi: 10.1016/S0140-6736(16)32517-X. Epub 2016 Dec 13. Erratum in: Lancet. 2017 Apr 8;389(10077):e5.

location_country:
Serbia
Spain
Italy
United Kingdom
Ukraine
United States
Japan
Poland
Portugal
Austria
Russian Federation
Argentina
Turkey
Panama
Norway
Sweden
Brazil
Canada
Switzerland
Guatemala
Hungary
Germany
Taiwan
Greece
New Zealand
Finland
Thailand
Korea, Republic of
France
Chile
Netherlands

location_facility: Sociedad de Investigaciones Medicas Ltda (SIM)

location_facility: Tampere University Hospital; Dept of Oncology

location_facility: IPO do Porto; Servico de Oncologia Medica

location_facility: Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology

location_facility: Cite de La Sante de Laval; Hemato-Oncologie

location_facility: Auckland city hospital; Auckland Regional Cancer Centre and Blood Service

location_facility: Hospital Universitario La Paz; Servicio de Oncologia

location_facility: Aichi Cancer Center Hospital; Respiratory Medicine

location_facility: Comprehensive Cancer Centers of Nevada - Eastern Avenue

location_facility: Centre Hospitalier Lyon Sud; Pneumologie

location_facility: Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia

location_facility: National Cancer Center Hospital East; Thoracic Oncology

location_facility: The Cancer Institute Hospital of JFCR, Respiratory Medicine

location_facility: Texas Oncology, P.A. - Tyler; Tyler Cancer Center

location_facility: Hospital Ramon y Cajal; Servicio de Oncologia

location_facility: Azienda Ospedaliero-Uni Ria Di Udine; Dept. Di Oncologia - Padiglione Pennato

location_facility: Samsung Medical Center; Gastroenterology

location_facility: N.N.Burdenko Main Military Clinical Hospital; Oncology Dept

location_facility: Univ of Calif, Los Angeles; Hematology/Oncology

location_facility: SBI of Healthcare Samara Regional Clinical Oncology Dispensary

location_facility: Irccs Ospedale San Raffaele;Oncologia Medica

location_facility: Helsinki University Central Hospital; Dep. of Pulmonary Medicine

location_facility: Luckow Pavillion, Valley Hosp; Office of Clinical Trials

location_facility: Hematology-Oncology; Associates of the Quad Cities

location_facility: Hospital Universitario Miguel Servet; Servicio Oncologia

location_facility: Seconda Universita' Degli Studi; Divsione Di Oncologia Medica

location_facility: Hospital Pulido Valente; Servico de Pneumologia

location_facility: Kaiser Permanente Sacramento Medical Center

location_facility: US Oncology Research at Minnesota Oncology

location_facility: Northwest Cancer Specialists - Vancouver

location_facility: Azienda Ospedaliera San Giuseppe Moscati

location_facility: IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda

location_facility: Yonsei University Severance Hospital; Medical Oncology

location_facility: Institute for pulmonary diseases of Vojvodina

location_facility: Centre Jean Bernard; Radiotherapie Chimiotherapie

location_facility: Roy & Patricia Disney Family Cancer Center

location_facility: Azienda Ospedaliera Univ Parma; Dept Oncologia Medica

location_facility: Seoul St.Mary's Hospital; Medical Oncology

location_facility: Lkh innsbruck - univ. Klinikum innsbruck - Tiroler landeskrankenanstalten ges.m.b.h.; Innere Medizin

location_facility: Clinic for Pulmonology, Clinical Center of Serbia

location_facility: University of Pecs, I st Dept of Internal Medicine

location_facility: Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie

location_facility: Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc

location_facility: Hospital Universitario Puerta de Hierro; Servicio de Oncologia

location_facility: St. Jude Heritage Healthcare; Virgiia K.Crosson Can Ctr

location_facility: Waikato Hospital; Dept of Medical Oncology

location_facility: Willamette Valley Cancer Ctr - 520 Country Club

location_facility: Uni Cattolica Policlinico Gemelli; Oncologia Medica Ist. Medicina Interna

location_facility: National Cancer Center Hospital; Thoracic Medical Oncology

location_facility: National Hospital Organization Kinki-Chuo Chest Medical Center; Internal Medicine

location_facility: National Hospital Organization Shikoku Cancer Center; Internal Medicine

location_facility: Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Klinika Nowotworów Piersi i Chirurgii

location_facility: Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii

location_facility: Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.

location_facility: Lkh Vöcklabruck; I. Abt. Für Innere Medizin

location_facility: University Hospital of Patras Medical Oncology

location_facility: Hospital Universitario 12 de Octubre; Servicio de Oncologia

location_facility: Kaiser Permanente - San Francisco (2238 Geary)

location_facility: Kaiser Permanente - Franklin; Kaiser Permanente - Lone Tree

location_facility: National Hospital Organization Kyushu Cancer Center, Thoracic Oncology

location_facility: Izmir Suat Seren Chest Diseases and Surgery Research Hospital

location_facility: Okayama University Hospital; Respiratory and Allergy Medicine

location_facility: National Hospital Organization, Yamaguchi - Ube Medical Center; Oncology Medicine

location_facility: Seoul National Uni Hospital; Internal Medicine

location_facility: Hospital Regional Universitario Carlos Haya; Servicio de Oncologia

location_facility: Semmelweis Egyetem X; Pulmonologiai Klinika

location_facility: A.O.U. Integrata Verona - Policlinico G.B. Rossi; Oncologia Medica - Dip. di Medicina

location_facility: Tokyo Medical University Hospital; Dept of Surgery

location_facility: Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii

location_facility: Fundacion Jimenez Diaz; Servicio de Oncologia

location_facility: Kantonsspital Baden; Medizinische Klinik, Onkologie

location_facility: Shizuoka Cancer Center; Thoracic Oncology

location_facility: National Cancer Center; Medical Oncology

location_facility: Centre Hospitalier Intercommunal; Service de Pneumologie

location_facility: Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie

location_facility: North Valley Hem Onc Med Grp; Thomas&Dorothy Leavey Can Ctr

location_facility: Miyagi Cancer Center; Respiratory Medicine

location_facility: Karmanos Cancer Inst. ; Hudson Webber; Cancer Research Building

location_facility: A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii

location_facility: National Taiwan Uni Hospital; Internal Medicine

location_facility: Istituto Nazionale per la Ricerca sul Cancro di Genova

location_facility: POLICLINICO RODOLICO, U.O. di Oncologia Medica

location_facility: Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie

location_facility: Bradford Hill Centro de Investigaciones Clinicas; Bradford Hill Centro de Investigaciones Clinicas

location_facility: Hospital Universitario Clínico San Carlos; Servicio de Oncologia

location_facility: Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)

location_facility: Guys and St Thomas NHS Foundation Trust, Guys Hospital

location_facility: Cancer Treatment Centers of America-Tulsa

location_facility: Kobe City Medical Center General Hospital; Respiratory Medicine

location_facility: Hopital Cochin; Unite Fonctionnelle D Oncologie

location_facility: Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica

location_facility: Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II

location_facility: New York Oncology Hematology PC - Latham

location_facility: Uzhgorod Nat. University Central Municip Hosp; Onc Center

location_facility: Aurora Health Care; Patient Centered Research

location_facility: Catharina Ziekenhuis; Dept of Lung Diseases

location_facility: Hopital de Pontchaillou; Service de Pneumologie

location_facility: McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology

location_facility: Chulalongkorn Hospital; Medical Oncology

location_facility: Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology

location_facility: Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología

location_facility: Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica

location_facility: Oslo Universitetssykehus HF; Radiumhospitalet

location_facility: Chang Gung Medical Foundation - Linkou; Division of Hematology- Oncology

location_facility: Karolinska Universitetssjukhuset, Solna; Lung Allergikliniken N10:02

location_facility: Luzerner Kantonsspital; Medizinische Onkologie

location_facility: Seoul National University Bundang Hospital; Hematology Medical Oncology

location_facility: Antonius Ziekenhuis; Dept of Lung Diseases

location_facility: Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique

location_facility: Kindai University Hospital; Medical Oncology

location_facility: Saitama Cancer Center; Thoracic Oncology

location_facility: Chu Grenoble - Hopital Albert Michallon; Departement de Cancero-Hematologie

location_facility: Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology

location_facility: St. Mary's Hospital Regional Cancer Center

summary: This global, multicenter, open-label, randomized, controlled study evaluated the efficacy and safety of atezolizumab (an anti-programmed death-ligand 1 [anti-PD-L1] antibody)compared with docetaxel in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure with platinum-containing chemotherapy. Participants were randomized 1:1 to receive either docetaxel or atezolizumab. Treatment may continue as long as participants experienced clinical benefit as assessed by the investigator, i.e., in the absence of unacceptable toxicity or symptomatic deterioration attributed to disease progression.


title: MOre REsponse on Cardiac Resynchronization Therapy (CRT) With MultiPoint Pacing (MPP)

acronym: MORE-CRT MPP

summary: The purpose of this Clinical investigation is to assess the impact of the Multi Point Pacing (MPP) feature at 12 months in the treatment of patients not responding to standard Cardiac Resynchronization Therapy (CRT) after 6 months.

status: Terminated

ReferenceCitation: Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Calò L, Vicentini A, Concha JF, Thibault B. Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from Phase I. Eur Heart J. 2019 Sep 14;40(35):2979-2987. doi: 10.1093/eurheartj/ehz109.

ReferenceCitation: Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Cohorn C, Thibault B; MORE-CRT MPP Investigators. Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II). Am Heart J. 2019 Mar;209:1-8. doi: 10.1016/j.ahj.2018.12.004. Epub 2018 Dec 8.

lead_sponsor: Abbott Medical Devices

location_country:
Saudi Arabia
Italy
Spain
United Kingdom
United States
Belgium
Poland
Portugal
Austria
Australia
Puerto Rico
India
Israel
Malta
Malaysia
Singapore
Sweden
Lebanon
Canada
Switzerland
China
Germany
Denmark
Taiwan
Greece
Finland
Korea, Republic of
France
Colombia
Netherlands

location_facility: Deutsches Herzzentrum München des Freistaates Bayern

location_facility: Azienda Ospedaliera "Civile - Maria Paternò Arezzo"

location_facility: Az Osp.Universitaria Maggiore della Carità

location_facility: Centro Hospitalar do Alto Ave, Unidade de Guimarães

location_facility: CHI Health Creighton University Medical Center-Bergan Mercy

location_facility: University of Texas Southwestern Medical Center at Dallas

location_facility: Manchester Heart Center, Manchester Royal Infirmary

location_facility: Baylor All Saints Medical Center at Fort Worth

location_facility: Hopital Cantonal Universitaire de Geneva

location_facility: Samaritan Heart & Vascular Institute - Cardiology Dept.

location_facility: Azienda Ospedaliera S. Anna e S Sebastiano

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: American University of Beirut Medical Center

location_facility: St. Elizabeth Medical Center - South Unit

location_facility: Institute Cardio. Paris-Sud - Institut Jacques Cartier

location_facility: Szpital Kliniczny Premienienia Panskiego

location_facility: Complexo Hospitalario Universitario de Santiago

location_facility: Medizinische Einrichtungen der Universität zu Köln

location_facility: Wojewodzki Specjalistyczny Szpital im. Bieganskiego

location_facility: Hospital Universitario Virgen de la Nieves

location_facility: Ospedale Civile Maggiore di Verona Borgo Trento

location_facility: Universitäts-Herzzentrum Freiburg - Bad Krozingen

location_facility: McGill University Health Centre General Hospital

location_facility: Escorts Heart Institute and Research Centre

location_facility: Seoul National University Bundang Hospital

location_facility: Gornoslaskie Centrum Medyczne im.prof. Leszka Gieca

location_facility: Postgraduate Institute of Medical Education & Research

location_facility: Az. Osp. Universitaria Pisana-Presidio Santa Chiara

location_facility: Universitatsmedizin Berlin - Campus Benjamin Franklin (CBF)

location_facility: Herz- und Gefäßzentrum am Krankenhaus Neu-Bethlehem

location_facility: Hospital Universitari i Politecnic La Fe

location_facility: Centre Hospitalier de Belfort-Montbeliard

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: Ospedale S. Giovanni Calibita Fatebenefratelli di Roma

intervention_type: Device

status_simplified: Unknown


title: An International, Multicenter, Open-label, Randomized, Phase 3 Study of BLU-285 vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic Gastrointestinal Stromal Tumor (GIST)

lead_sponsor: Blueprint Medicines Corporation

ReferenceCitation: Kang YK, George S, Jones RL, Rutkowski P, Shen L, Mir O, Patel S, Zhou Y, von Mehren M, Hohenberger P, Villalobos V, Brahmi M, Tap WD, Trent J, Pantaleo MA, Schöffski P, He K, Hew P, Newberry K, Roche M, Heinrich MC, Bauer S. Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor: A Randomized, Open-Label Phase III Study. J Clin Oncol. 2021 Oct 1;39(28):3128-3139. doi: 10.1200/JCO.21.00217. Epub 2021 Aug 3.

ReferenceCitation: Gebreyohannes YK, Wozniak A, Zhai ME, Wellens J, Cornillie J, Vanleeuw U, Evans E, Gardino AK, Lengauer C, Debiec-Rychter M, Sciot R, Schöffski P. Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors. Clin Cancer Res. 2019 Jan 15;25(2):609-618. doi: 10.1158/1078-0432.CCR-18-1858. Epub 2018 Oct 1.

location_country:
Poland
Spain
Italy
Austria
Australia
Netherlands
Canada
United Kingdom
Sweden
Hungary
Korea, Republic of
United States
France
China
Singapore
Belgium
Germany
Czechia

location_facility: Onkologická klinika Fakultní nemocnice Olomouc

location_facility: The University of Chicago Medical Center

location_facility: Shanghai Jiaotong University School of Medicine, Renji Hospital

location_facility: Fundacion Instituto Valenciano de Oncologia, Servicio de Oncologia

location_facility: AOUC Azienda Ospedaliero - Universitaria Careggi

location_facility: The First Affiliated Hospital of Sun Yat-sen University

location_facility: Harbin Medical University Cancer Hospital

location_facility: Magyar Honvédség Egészségügyi Központ Onkológiai Osztály

location_facility: Sanodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwesytecki w Krakowie, Oddzial Kliniczny Onkologii

location_facility: The First Affiliated Hospital of Nanchang Medical University

location_facility: Fovarosi Onkormanyzat Szent Laszlo Korhaz

location_facility: Washington Hospital Center - Oncology and Hematology

location_facility: University of Michigan Comprehensive Cancer Center

location_facility: Fujian Medical University Union Hospital

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori Milano

location_facility: The First Affiliated Hospital of Chongqing Medical University

location_facility: Sheffield Teaching Hospitals NHS Foundation Trust

location_facility: Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis

location_facility: Institut Català d'Oncologia - Hospital Duran i Reynals

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej MSWiA z W-MCO

location_facility: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

location_facility: Azienda Ospedaliero Universitaria Sant'Orsola Malpighi

location_facility: The Affiliated Hospital of Qingdao University

location_facility: Guangxi Medical University Affiliated Tumor Hospital & Oncology Medical College

location_facility: Affiliated Cancer Hospital of Xinjiang Medical University

location_facility: The First Affiliated Hospital, Zhejiang University

location_facility: Maria Skodowska Curie Memorial Cancer Centre and Institute of Oncology

location_facility: Dolnoslaskie Centrum Onkologii we Wrocawiu

location_facility: Medical College of Wisconsin - Froedtert Hospital

location_facility: The Sixth Affiliated Hospital of Sun Yat-Sen University

location_facility: Studienzentrale GbR Lübecker Onkologische Schwerpunktpraxis Dres. med. Uthgenannt

location_facility: Universita degli Studi di Palermo - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

summary: This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2 other TKIs.


title: A Phase 3 Open Label, Randomized Study of BMS-986205 Combined With Nivolumab With or Without Chemotherapy Versus Chemotherapy in Participants With Previously Untreated Stage IV or Recurrent Non-Small Cell Lung Cancer

summary: This is a study of experimental medication BMS-986205 given with Nivolumab with or without chemotherapy compared to chemotherapy in participants with previously untreated stage IV or recurrent non-small cell lung cancer.

study_start_date_type: Anticipated

status: Withdrawn

lead_sponsor: Bristol-Myers Squibb

location_country:
Taiwan
Brazil
Spain
Greece
Austria
Australia
Italy
Canada
Switzerland
Korea, Republic of
United States
France
Turkey
Mexico
Japan
Germany
Czechia

intervention_type: Biological


title: A Multicenter, Open-label, Randomized, Active-controlled, Parallel Group, Pivotal Study to Investigate the Efficacy, Safety and Tolerability, and Pharmacokinetics of Murepavadin Combined With One Anti-pseudomonal Antibiotic Versus Two Anti-pseudomonal Antibiotics in Adult Subjects With Ventilator-associated Bacterial Pneumonia Suspected or Confirmed to be Due to Pseudomonas Aeruginosa

acronym: PRISM-MDR

summary: This is a phase 3, multicenter, open-label, randomized active-controlled, parallel group to investigate the efficacy, safety and tolerability, and pharmacokinetics of intravenous murepavadin combined with of one anti-pseudononas antibiotic with that of two anti-pseudomonas antibiotics in the treatment of ventilator-associated bacterial pneumonia (VABP) in adult subjects.

lead_sponsor: Polyphor Ltd.

location_country:
Croatia
Brazil
Spain
Greece
Estonia
Thailand
Hungary
Korea, Republic of
United States
France
Israel
South Africa
Mexico

location_facility:
Research site
Research site 3
Research site 2
Reasearch site
Research site 1
Research Site 3
Research Site 1
Research Site
Research Site 2


title: A 28-week, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multi-center, Study in Recombinant Human Erythropoietin (rhEPO) naïve Non-dialysis Participants With Anemia Associated With Chronic Kidney Disease to Evaluate the Efficacy, Safety and Effects on Quality of Life of Daprodustat Compared to Placebo

summary: The purpose of this multi-center study in non-dialysis participants with anemia associated with CKD is to evaluate safety, efficacy and quality of life of daprodustat compared to placebo.

ReferenceCitation: Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF. Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease. Cochrane Database Syst Rev. 2022 Aug 25;8:CD013751. doi: 10.1002/14651858.CD013751.pub2. Review.

ipd_sharing_description: IPD for this study will be made available via the Clinical Study Data Request site.

lead_sponsor: GlaxoSmithKline

location_country:
Poland
Brazil
Romania
Spain
Italy
Russian Federation
Australia
United Kingdom
Argentina
Canada
Korea, Republic of
United States
France
Mexico


status: Recruiting

title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-design Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

lead_sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

ipd_sharing_description: Anonymized Individual participant data (IPD) that underlie the results of this study will be shared with researchers to achieve aims pre-specified in a methodologically sound research proposal. Small studies with less than 25 participants are excluded from data sharing.

enrollment_type: Anticipated

location_country:
Poland
Spain
Italy
United Kingdom
Australia
Hungary
United States
France
South Africa
Bulgaria
Czechia

location_facility: Azienda Sanitaria Locale di Biella - Nuovo Ospedale degli Infermi

location_facility: Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak

location_facility: Northamptonshire Healthcare NHS Foundation Trust

location_facility: Centre Hospitalier Universitaire Dijon Bourgogn

location_facility: Fondazione Santa Lucia - Istituto di Ricovero e Cura a Carattere Scientifico

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

location_facility: Fundació Hospital de la Santa Creu i Sant Pau

location_facility: Meridien Research - Lakeland Site Site #558

location_facility: Alzheimer's Research and Treatment Center

location_facility: Clinline Services s.r.0 Psychiatricka Ambulance

location_facility: Dr. Mathe es Tarsa Beteti Tarsasa Site #593

location_facility: Dr. Kenessey Albert Kórház-Rendelőintézet

location_facility: Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre

location_facility: Neurology of Central Florida Rsch Ctr # 803

location_facility: Clinical Research Associates of South Florida

location_facility: DCC "Sv. Vrach and Sv. Sv. Kuzma and Damian" OOD

location_facility: Hospital General Universitario Gregorio Marañón

location_facility: University Multiprofile Hospital for Active Treatment Alexandrovska

location_facility: University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski

location_facility: Centro San Giovanni di Dio - Fatebenefratelli

location_facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz

location_facility: Beautiful Minds Clinical Research Center #808

location_facility: MAC Clinical Research - Barnsley Site #671

location_facility: South London and Maudsley NHS Foundation Trust

location_facility: Diagnostic-consultative center Mladost-М Varna OOD #711

location_facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

location_facility: Australian Alzheimer's Research Foundation

location_facility: Centre Hospitalier Universitaire de Saint-Étienne - Hôpital Nord

location_facility: North West Boroughs Healthcare NHS Foundation Trust

location_facility: Università degli studi G.D'Annunzio Chieti Pescara

location_facility: INEP Medical s.r.o. Institut Neuropsychiatricke Pece

location_facility: Azienda Ospedaliera San Gerardo di Monza

location_facility: Research Institute for the Care of Older People

location_facility: First Multiprofile Hospital for Active Treatment Sofia

location_facility: Alliance for Wellness, Inc dba Alliance for Research

location_facility: Paradigm Clinical Research Centers, Inc.

location_facility: Wasatch Clinical Research, LLC Site #771

location_facility: Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois

location_facility: Neurologiczny Niepubliczny Zakład Opieki Zdrowotnej

location_facility: Valeomed Egeszsegugyi es Szolgaltato Kft

location_facility: Centre Hospitalier Universitaire de Poitiers

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

location_facility: Nathan S. Kline Institute for Psychiatric Research

location_facility: Five Towns Neurology PC/Village Site #764

location_facility: Centre Hospitalier Universitaire Toulouse - Casselardit Ancely

location_facility: Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz

location_facility: Complejo Asistencial de Zamora Hospital Virgen de la Concha

location_facility: Azienda Ospedaliero - Universitaria Careggi

location_facility: Avon and Wiltshire Mental Health Partnership NHS Trust

location_facility: Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: Centre Hospitalier Universitaire de Nantes - Hôpital Nord Laennec

location_facility: Wielospecjalistyczna Poradnia Lekarska Synapsis

location_facility: CRU Hungary Egészségügyi és Szolgáltató Korlátolt Felelősségű Társaság

location_facility: Fejér Megyei Szent György Egyetemi Oktató Kórház

location_facility: Hospital Universitario y Politécnico de La Fe

location_facility: Hospital Universitario Marqués de Valdecilla

summary: This study will be conducted to evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in participants with dementia of the Alzheimer's type.


primary_purpose: Prevention

acronym: SOCRATES

title: A Randomised, Double-Blind, Multinational Study to Prevent Major Vascular Events With Ticagrelor Compared to Aspirin (ASA) in Patients With Acute Ischaemic Stroke or TIA.

ReferenceCitation: Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10. Review.

ReferenceCitation: Evans SR, Knutsson M, Amarenco P, Albers GW, Bath PM, Denison H, Ladenvall P, Jonasson J, Easton JD, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC. Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clin Trials. 2020 Dec;17(6):617-626. doi: 10.1177/1740774520941441. Epub 2020 Jul 15.

ReferenceCitation: Cucchiara B, George DK, Kasner SE, Knutsson M, Denison H, Ladenvall P, Amarenco P, Johnston SC. Disability after minor stroke and TIA: A secondary analysis of the SOCRATES trial. Neurology. 2019 Aug 13;93(7):e708-e716. doi: 10.1212/WNL.0000000000007936. Epub 2019 Jul 11.

ReferenceCitation: Easton JD, Denison H, Evans SR, Knutsson M, Amarenco P, Albers GW, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC; SOCRATES Steering Committee and Investigators. Estimated treatment effect of ticagrelor versus aspirin by investigator-assessed events compared with judgement by an independent event adjudication committee in the SOCRATES trial. Int J Stroke. 2019 Dec;14(9):908-914. doi: 10.1177/1747493019851282. Epub 2019 May 15.

ReferenceCitation: Molina CA, Johnston SC, Ladenvall P, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Knutsson M, Minematsu K, Röther J, Wang Y, Wong KSL; SOCRATES Steering Committee and Investigators. Time to Loading Dose and Risk of Recurrent Events in the SOCRATES Trial. Stroke. 2019 Mar;50(3):675-682. doi: 10.1161/STROKEAHA.118.022675. Erratum in: Stroke. 2019 Apr;50(4):e118.

ReferenceCitation: Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18.

ReferenceCitation: Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. Stroke. 2017 Sep;48(9):2480-2487. doi: 10.1161/STROKEAHA.117.017217. Epub 2017 Jul 18.

ReferenceCitation: Easton JD, Aunes M, Albers GW, Amarenco P, Bokelund-Singh S, Denison H, Evans SR, Held P, Jahreskog M, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Circulation. 2017 Sep 5;136(10):907-916. doi: 10.1161/CIRCULATIONAHA.117.028566. Epub 2017 Jun 27.

ReferenceCitation: Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol. 2017 Apr;16(4):301-310. doi: 10.1016/S1474-4422(17)30038-8. Epub 2017 Feb 23.

ReferenceCitation: Wang Y, Minematsu K, Wong KS, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Molina CA, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Stroke. 2017 Jan;48(1):167-173. doi: 10.1161/STROKEAHA.116.014891. Epub 2016 Nov 29.

ReferenceCitation: Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10. Review.

ReferenceCitation: Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Jul 7;375(1):35-43. doi: 10.1056/NEJMoa1603060. Epub 2016 May 10.

location_country:
Spain
Italy
Ukraine
United States
Peru
Belgium
Philippines
Japan
Romania
Czechia
Poland
Hong Kong
Russian Federation
Australia
Argentina
Israel
Turkey
Mexico
Sweden
Slovakia
Brazil
Canada
Switzerland
Hungary
China
Germany
Bulgaria
Taiwan
Thailand
Vietnam
Korea, Republic of
France
Chile

summary: The primary objective of the study is to compare the effect of 90-day treatment with ticagrelor (180 mg [two 90 mg tablets] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-aspirin (300 mg [three 100 mg tablets] loading dose on Day 1 followed by 100 mg once daily maintenance dose for the remainder of the study) for the prevention of major vascular events (composite of stroke, myocardial infarction [MI], and death) in patients with acute ischaemic stroke or transient ischaemic attack (TIA).


acronym: THEMIS

title: A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor Twice Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients With Type 2 Diabetes Mellitus (THEMIS - Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study).

ReferenceCitation: Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, Held C, Andersson M, Himmelmann A, Ridderstråle W, Leonsson-Zachrisson M, Liu Y, Opolski G, Zateyshchikov D, Ge J, Nicolau JC, Corbalán R, Cornel JH, Widimský P, Leiter LA; THEMIS Steering Committee and Investigators. Ticagrelor in Patients with Stable Coronary Disease and Diabetes. N Engl J Med. 2019 Oct 3;381(14):1309-1320. doi: 10.1056/NEJMoa1908077. Epub 2019 Sep 1.

ReferenceCitation: Bhatt DL, Steg PG, Mehta SR, Leiter LA, Simon T, Fox K, Held C, Andersson M, Himmelmann A, Ridderstråle W, Chen J, Song Y, Diaz R, Goto S, James SK, Ray KK, Parkhomenko AN, Kosiborod MN, McGuire DK, Harrington RA; THEMIS Steering Committee and Investigators. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial. Lancet. 2019 Sep 28;394(10204):1169-1180. doi: 10.1016/S0140-6736(19)31887-2. Epub 2019 Sep 1.

ReferenceCitation: Bhatt DL, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Andersson M, Himmelmann A, Ridderstråle W, Held C, Steg PG; THEMIS Steering Committee. Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study. Clin Cardiol. 2019 May;42(5):498-505. doi: 10.1002/clc.23164. Epub 2019 Apr 9.

ReferenceCitation: Abtan J, Bhatt DL, Elbez Y, Ducrocq G, Goto S, Smith SC Jr, Ohman EM, Eagle KA, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Petrov I, Sinnaeve PR, Pais P, Lev E, Bueno H, Wilson P, Steg PG; REACH Registry Investigators. External applicability of the Effect of ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) trial: An analysis of patients with diabetes and coronary artery disease in the REduction of Atherothrombosis for Continued Health (REACH) registry. Int J Cardiol. 2022 Oct 19. pii: S0167-5273(22)01643-6. doi: 10.1016/j.ijcard.2022.10.132. [Epub ahead of print]

ReferenceCitation: Wittbrodt E, Bhalla N, Sundell KA, Hunt P, Wong ND, Kuster M, Mellström C. Assessment of The High risk and unmEt Need in patients with CAD and type 2 diabetes (ATHENA): US healthcare resource use, cost, and burden of illness in a commercially insured population. J Diabetes Complications. 2021 Apr;35(4):107859. doi: 10.1016/j.jdiacomp.2021.107859. Epub 2021 Jan 20.

location_country:
Saudi Arabia
Italy
Spain
United Kingdom
Ukraine
United States
Peru
Belgium
Japan
Philippines
Romania
South Africa
Czechia
Poland
Hong Kong
Austria
Australia
Russian Federation
Argentina
Puerto Rico
India
Israel
Turkey
Mexico
Norway
Sweden
Slovakia
Brazil
Canada
Hungary
China
Germany
Bulgaria
Denmark
Taiwan
Finland
Thailand
Vietnam
Korea, Republic of
France
Chile
Colombia
Netherlands

summary: The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.


title: Phase 3 Multi Center, Double Blind, Randomized, Placebo Controlled, Parallel Group Evaluation Of The Efficacy, Safety, And Tolerability Of Bococizumab (Pf-04950615), In Reducing The Occurrence Of Major Cardiovascular Events In High Risk Subjects

summary: This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and unstable angina requiring urgent revascularization in high risk subjects who are receiving background lipid lowering therapy and have cholesterol laboratory values of LDL-C >/= 100 mg/dL (2.6 mmol/L) or non-HDL-C >/=130 mg/dL (3.4 mmol/L).

ReferenceCitation: Chasman DI, Hyde CL, Giulianini F, Danning RD, Wang EQ, Hickling T, Ridker PM, Loomis AK. Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1. Sci Rep. 2022 Mar 11;12(1):4266. doi: 10.1038/s41598-022-07997-5.

ReferenceCitation: Pradhan AD, Aday AW, Rose LM, Ridker PM. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. 2018 Jul 10;138(2):141-149. doi: 10.1161/CIRCULATIONAHA.118.034645. Epub 2018 May 1.

ReferenceCitation: Ridker PM, Rose LM, Kastelein JJP, Santos RD, Wei C, Revkin J, Yunis C, Tardif JC, Shear CL; Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab. J Clin Lipidol. 2018 Jul - Aug;12(4):958-965. doi: 10.1016/j.jacl.2018.03.088. Epub 2018 Apr 3.

ReferenceCitation: Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.

lead_sponsor: Pfizer

location_country:
Spain
Italy
United Kingdom
United States
Belgium
Romania
South Africa
Czechia
Poland
Russian Federation
Australia
Argentina
Puerto Rico
India
Israel
Turkey
Mexico
Sweden
Slovakia
Brazil
Canada
Switzerland
Hungary
Germany
Denmark
Taiwan
Ireland
New Zealand
Finland
Thailand
Korea, Republic of
France
Chile
Colombia
Netherlands

location_facility: Clinica Privada de Especialidades Medicas

location_facility: Institute of Cardiovascular Diseases Timisoara

location_facility: Solutions Through Advanced Research, Inc.

location_facility: Stroke Prevention & Atherosclerosis Research Centre (SPARC)

location_facility: Hospital Clinico Universitario de Santiago de Compostela

location_facility: Centre Integre de Sante et de services sociaux de Chaudiere-Appalaches (CISSA-CA) -

location_facility: Centro de Investigacion Clinica del Pacifico, S.A. de C.V.

location_facility: Philadelphia Health Associates-Adult Medicine

location_facility: SMO.MD GmbH - Zentrum fÃ¼r klinische Studien

location_facility: Vita Health & Medical Center, Inc./Concept Clinical Trials, LLC

location_facility: Wojskowy Instytut Medyczny, Klinika Kardiologii i Chorob Wewnetrznych, Centralny Szpital Kliniczny

location_facility: ProMedica Northwest Ohio Cardiology Consultants

location_facility: Diabmed Dr. Popescu Alexandrina SRL, Diabet, Nutritie, Boli Metabolice

location_facility: Spitalul Universitar De Urgenta Militar Central, Dr. Carol Davila

location_facility: NZOZ Centrum Zdrowia i Profilaktyki Dabie Sp. z.o.o.

location_facility: State Institution of Healthcare "Regional Clinical Hospital"

location_facility: Ocean Blue Medical Research Center, Inc.

location_facility: County Clinical Emergency Hospital Sibiu

location_facility: Cardiovascular Research of Northwest Indiana, LLC

location_facility: Narodny ustav srdcovych a cievnych chorob, a.s.

location_facility: Consultorio Medico de Especialidad Dr. Demetrio Kosturakis Garcia

location_facility: Cleveland Clinic - Taussig Cancer Institute

location_facility: Unidad de Investigacion Clinica y Atencion Medica Hepa S.C.

location_facility: Synexus Polska Sp. z o.o Oddzial w Poznaniu

location_facility: Spitalul Clinic Judetean De Urgenta Cluj-Napoca, Diabet Zabarat

location_facility: Holy Spirit Northside Private Hospital Limited

location_facility: Forskningsenheten, Medicinmottagningen Sahlgrenska Universitetssjukhuset/Molndal, Hus J

location_facility: St. Mary's Medical Center dba Essentia Health St. Mary's Medical Center

location_facility: Prywatny Gabinet Lekarski Dr n. med. Michal Ogorek

location_facility: Kardiocentrum Nitra s.r.o., kardiologicka ambulancia

location_facility: NeuroCor Banaszkiewicz, Kulaga, Ostrowska, Tomaszewski lekarze spolka partnerska

location_facility: Dr. Mistodie Cristina Victoria MD, Office of

location_facility: State Budgetary Healthcare Institution of Yaroslavl Region "Clinical Hospital No. 10"

location_facility: Sparrow Thoracic & Cardiovascular Institute

location_facility: Metabolicke Centrum MUDr. Katariny Raslovej, S.R.O.

location_facility: Seoul Metropolitan Government - Seoul National University Boramae Medical Center

location_facility: Endocrine Lipid Diabetes Research Institute

location_facility: Central Coast Local Health District, Gosford Hospital

location_facility: Liptovska nemocnica s poliklinikou MUDr.Ivana Stodolu Liptovsky Mikulas

location_facility: Cardiology Associates of Fairfield County, PC

location_facility: "SAHI of Kemerovo ""Regional Clinical Hospital of Emergency Medical Care n.a. M.A Podgorbunsky """

location_facility: Synexus Thames Valley Clinical Research Centre

location_facility: Southern Health & Social Care Trust, Craigavon Area Hospital

location_facility: Elite Clinical Trials (Additional Administrative Room / Exam Rooms)

location_facility: Grand Hopital de Charleroi, Site St-Joseph

location_facility: Synexus Midlands Clinical Research Centre

location_facility: AOU Policlinico "Mater Domini" UOC di Medicina Interna

location_facility: Hvidovre Universitetshospital, Hjerte-lungemedicinsk afdeling

location_facility: Clinical Research Advantage, Inc./Michigan Avenue Internists

location_facility: Evanston Premier Healthcare Research, LLC

location_facility: SBEI of HPE "First Pavlov State Medical University of St. Petersburg" of the MoH of the RF

location_facility: Midwest Heart & Vascular Specialists, LLC

location_facility: Northeast Iowa Medical Education Foundation

location_facility: Jeleniogorskie Centrum Chorob Serca, Przychodnia Kardiologiczna, Poradnia Kardiologiczna

location_facility: SBHI of Saint-Petersburg "City Hospital # 38 n.a. N.A. Semashko"

location_facility: Vergelegen Mediclinic-Helderberg Research Institute

location_facility: Schwerpunktpraxis Dr. Luedemann fuer Diabetes Gefaess- und Ernaehrungsmedizin

location_facility: FSBI "Research institute of complex problems of cardio-vascular diseases" of

location_facility: Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza Oddzial

location_facility: Azienda Ospedaliera Della Provincia Di Lecco - Ospedale Manzoni

location_facility: State Budgetary Healthcare Institution "Samara Regional Clinical Cardiology Dispensary"

location_facility: Prywatny Gabinet Lekarski Marianna Janion

location_facility: Gemeinschaftspraxis Drs Haggenmiller/Jeserich, Kardiologie, Angiologie, Innere Medizin

location_facility: Albert Schweitzer Ziekenhuis-Albert Schweitzer Hospital

location_facility: Ufuk University School of Medicine, Dr. Ridvan Ege Training & Research Hospital

location_facility: Tyumen Cardiology Research Center-branch of the Tomsk NRMC

location_facility: Bezmialem Vakif Universitesi Tip Fakultesi Kardiyoloji Bolurnu

location_facility: Synexus Leipzig Clinical Research Centre

location_facility: Landa Specjalistyczne Gabinety Lekarskie

location_facility: Sociedade Hospitalar Angelina Caron/Hospital e Maternidade Angelina Caron

location_facility: California Medical Research Associates Inc.

location_facility: Jacksonville Center for Clinical Research

location_facility: UN Bratislava Nemocnica Sv.Cyrila a Metoda, kardiologicka ambulancia 1

location_facility: Medivasa S.R.O., Diabetologicka Ambulancia

location_facility: Cardiology Consultants of Orange County Medical Group, Inc.

location_facility: Glacier View Research Institute, Cardiology

location_facility: Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny Boguslaw Derlaga

location_facility: Atlanta Center for Clinical Research / Internal Medicine

location_facility: John Muir Physician Network Clinical Research Center

location_facility: Dr. Richard Bon Inc. & Dr. Adam Yeung Inc.

location_facility: Oklahoma Heart Hospital Research Foundation

location_facility: Centrul Medical Dr. Negrisanu SRL, Diabet Zaharat Nutritie si Boli Metabolice

location_facility: Municipal Budgetary Institution of Healthcare Municipal Clinical Hospital #3 n.a. M.A. Podgorbunsky

location_facility: Faculty of Medicine, Srinagarind Hospital, Khon Kaen University

location_facility: Uijeongbu St. Mary's Hospital-The Catholic University of Korea

location_facility: Vizel Cardiac Research - Saul Vizel Professional Medicine Corporation

location_facility: State Autonomous Healthcare Institution of Tyumen region "Scientific-Practical Medical Center"

location_facility: Centrum kardiovaskularni prevence 1. LF UK a TN

location_facility: Federal State Budgetary Educational Institution of Higher Education "Kazan State Medical University"

location_facility: Federal State Budget Institution "Out-patient Clinic #3" of Russian Federation, President's

location_facility: FSHI "Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia across

location_facility: Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: West Jefferson Heart Clinic of Louisiana New Orleans Physician Services, Inc.

location_facility: Clinical Research Institute of Northern Virginia

location_facility: Instituto de Cardiologia do Rio Grande do Sul / Fundacao Universitaria de Cardiologia

location_facility: Hospital Mae de Deus - Instituto do Cancer

location_facility: Regional Budgetary Healthcare Institution "Cardiology Dispensary"

location_facility: BV Medical, s.r.o. Diabetologicka ambulancia,

location_facility: Investigative Clinical Research of Indiana, LLC

location_facility: Consultorio Dr. Leocadio Gerardo Munoz Beltran

location_facility: Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre

location_facility: Green and Seidner Family Practice Associates

location_facility: Asociacion IPS Medicos Internistas de Caldas

location_facility: Pecsi Tudomanyegyetem AOK, I. Belgyogyaszati Klinika

location_facility: John V. Bernard, MD dba Wellness and Research Center

location_facility: Kirov Regional State Budgetary Healthcare Institution "Kirov City Clinical Hospital #1"

location_facility: Clinphenomics Gmbh & Co Kg, Studienzentrum

location_facility: EMED Centrum Uslug Medycznych Ewa Smialek

location_facility: Cardiovascular Research Foundation of Southern California

location_facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)

location_facility: Instituto de Cardiologia de Corrientes "Juana Fca. Cabral"

location_facility: CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda

location_facility: Centre Hospitalier de Cannes- Service de Cardiologie

location_facility: A.O. di Reggio Emilia Arcispedale "S. Maria Nuova"/IRCCS

location_facility: IP + Dry ice deliveries Sugar Lakes Family Practice

location_facility: Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran"

location_facility: University of Iowa-College of Public Health-Preventive Intervention Center

location_facility: MUDr. Antonin Dufka, kardiologicka ambulance

location_facility: Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

location_facility: Instituto de Investigaciones Clinicas Bahia Blanca

location_facility: Instituto Cardiovascular De Buenos Aires

location_facility: SBHI Moscow city "City Clinical Hospital #15 n.a. O.M. Filatova" of Moscow Healthcare Department

location_facility: Fakultna nemocnica s poliklinikou Nove Zamky, I. interna klinika

location_facility: Instytut Kardiologii, Ii Klinika Choroby WieCowej

location_facility: Hospital Provincial Dr. Jose Maria Cullen

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: CPClin- Centro de Pesquisas Clinicas Ltda./Clinica Dr. Freddy Goldberg Eliaschewitz

location_facility: Podoleanu G. Cristian-Gheorghe-Calin - Cardiology Medical Practice

location_facility: Division of Cardiology, Department of Medicine, Faculty of Medicine, Siriraj Hospital,

location_facility: Maerkische Kliniken GmbH, Klinikum Luedenscheid, Innere III

location_facility: Foothills Hospital/University of Calgary

location_facility: Hospital Clinico Universitario Miguel Servet; Medicina Interna

location_facility: Municipal Budgetary State Healthcare Institution "City Clinical Hospital #6"

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital - New

location_facility: Centro Especializado en Diabetes Obesidad y Prevencion de Enfermedades Cardiovasculares, SC.

location_facility: Midwest Cardiovascular Research Foundation

location_facility: MHI "City Clinical Hospital 12"of the Healthcare Committee of

location_facility: State Regional Budgetary Healthcare Institution

location_facility: The Office of Roberto J. Ayala-Rios, MD - Research Center and Private Practice (DMRA LLC)

location_facility: North Shore Hospital- Inpatient Pharmacy

location_facility: Global Trial Research Center S.A. de C.V.

location_facility: Northeast Clinical Research of San Antonio, LLC (NECRSA, LLC)

location_facility: State Budgetary Institution "Ryazan Regional Clinical Hospital"

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Alexandrovskaya Hospital"

location_facility: County Clinical Emergency Hospital Oradea

location_facility: Synexus Polska Sp. z o.o. Oddzial w Katowicach

location_facility: Synexus Polska Sp. z o.o. Oddzial w Warszawie

location_facility: Cardiology Research Associates of New Brunswick

location_facility: Cranbrook Cardiology Research Associates

location_facility: Southern Clinical Trials Shirley Ltd Don Beavan Medical Research Centre

location_facility: Szpital Specjalistyczny im. J. Dietla w Krakowie, Oddzial Kardiologii

location_facility: State Budgetary Healthcare Institution of Moscow Region "Lubertsy Regional Hospital #2"

location_facility: Szegedi Tudomanyegyetem AOK, I. sz Belgyogyaszati Klinika

location_facility: VA North Texas Health Care System - Dallas VAMC

location_facility: State Budgetary Educational Institution Of Higher Professional Education

location_facility: Joondalup Cardiovascular Trials Foundation Inc.

location_facility: Lahoja Asociacion para la Investigacion y Farmacovigilancia S.C.

location_facility: Instituto del Corazon de Bucaramanga S.A.

location_facility: Hospital Universitario San Juan de Alicante

location_facility: Consultorios Asociados de Endocrinologia e Investigacion Clinica Aplicada

location_facility: Instituto Nacional de Ciencia Medicas y Nutricion Salvador Zubiran

location_facility: INTERCARD Sp. z o.o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Krosnie

location_facility: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

location_facility: FSBEI of HE Kazan State Medical University on the base of SBHI Clinical Hospital No.2

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku

location_facility: Municipal Budgetary Institution of Healthcare of Novosibirsk

location_facility: Federal State Budgetary Institution "Federal Almazov Medical Research Centre" of

location_facility: Jehangir Clinical Development Centre Pvt. Ltd.

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: Berlin Research Centre-Synexus Clinical Research GmbH

location_facility: Fundacion del Caribe para la Investigacion Biomedica - Fundacion BIOS

location_facility: Elisabeth-TweeSteden Ziekenhuis (previously named St. Elisabeth Ziekenhuis)

location_facility: Morton Plant Mease Health Care, Inc. Cardiovascular Research

location_facility: Institution Centrul Medical Sf. Stefan SRL, Diabet Nutritie si Boli Metabolice

location_facility: "Federal State Budgetary Institution "Russian Cardiology Research And Production Complex" Of

location_facility: Clinical Research Advantage, Inc./Simon Williamson Clinic

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Sp. z o.o.

location_facility: Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi

location_facility: Instituto Biomedico De Investigacion A.C.

location_facility: Operadora de Hospitales Angeles S.A. de C.V. (Emergencies)

location_facility: Kardiologische Gemeinschaftspraxis Dres Med. Gerke/Burger

location_facility: Clinical Research Advantage, Inc. / Family Medicine Associates

location_facility: Synexus Helderberg Clinical Research Centre

location_facility: DiGiovanna Institute for Medical Education And Research

location_facility: Synexus Watermeyer Clinical Research Centre

location_facility: KARDIO-SANUS spol.,s.r.o.,Kardiologicka, interna a sonograficka ambulancia

location_facility: London Road Diagnostic Clinic and Medical Centre

location_facility: Spitalul Clinic Colentina, Departament Cardiologie

location_facility: CAEP - Centro Avançado de Estudos e Pesquisas Ltda.

location_facility: Amh/Feasterville Family Health Care Center

location_facility: Hospitaux Universitaires de Geneve (HUG)

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala

location_facility: Caja de Compensacion Familiar CAFAM, Sede Centro de Atencion en Salud CAFAM FLORESTA

location_facility: Gangnam Severance Hospital, Yonsei University Health System

location_facility: Fakultni nemocnice Hradec Kralove, III. Interni gerontometabolicka klinika

location_facility: San Diego Family Care dba Linda Vista Health Center

location_facility: Istanbul Universitesi Istanbul Tip Fakultesi

location_facility: Gerencia de Gestion integrada de A Coruna

location_facility: Section of Nephrology and Hypertension, LSU Health Sciences Center-New Orleans

location_facility: State Budgetary Institution of Healthcare of Kaluga Region "Kaluga Regional Hospital"

location_facility: Divisione di Cardiologia con Utic ed Emodinamica - AOU Federico II di Napoli

location_facility: Baskent University, Adana Yuregir Training & Research Hospital

location_facility: Allina Health System, dba Abbott Northwestern Hospital

location_facility: Spitalul Clinic Judetean De Urgenta Braila(Braila County Clincal Emergency Hospital)

location_facility: SMO.MD GmbH, Zentrum fuer klinische Studien Site Management and Clinical Research Unit

location_facility: Stredoslovensky ustav srdcovych a cievnych chorob a.s.

location_facility: Hospital Universitario La Paz; Unidad Metabolico-Vascular

location_facility: Ospedale Civile Regionale San Martino, Belluno

location_facility: State Healthcare Institution of Yaroslavl Region "Clinical Hospital #8"

location_facility: Cardiology Partners Clinical Research Institute

location_facility: Centre Hospitalier De Bourg En Bresse - Hopital Fleyriat

location_facility: The Office of Maxine E. Hamilton, MD, PA

location_facility: GWT-TUD GmbH, Studienzentrum Professor Hanefeld

location_facility: Ospedale S. Maria della Misericordia -Dipartimento di Medicina, Medicina Interna,

location_facility: Klinik und Poliklinik fuer Innere Medizin B-Kardiologie, Angiologie, Pulmologie, Internistische

location_facility: Rabin Medical Center, Beilinson Hospital

location_facility: Premier Health Specialists, Inc. (dba Dayton Heart Center)

location_facility: Miguel Sosa-Padilla, MD-Private Practice

location_facility: Hospital Universitario Sant Joan de Reus

location_facility: """OSTEO-MEDIC"" s.c. Artur Racewicz, Jerzy Supronik"

location_facility: CIPREC - Centro de Investigacion y Prevencion Cardiovascular S.A.

location_facility: "OSTEO-MEDIC" s.c. Artur Racewicz, Jerzy Supronik

location_facility: Endiamed s.r.o. Nestatna diabetologicka a endokrinologicka ambulancia

location_facility: University of Alabama at Birmingham (Drug Shipment)

location_facility: Pro Familia Altera Poradnia Wielospecjalistyczna

location_facility: Clinical Trials Unit,Bay of Plenty(BOP) Clinical School

location_facility: Specjalistyczna Praktyka Lekarska Piotr Kubalski

location_facility: Mae de Deus - Centro de Oncologia Radioterapica (COR)

location_facility: Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut

location_facility: Wojewodzki Szpital Zespolony w Elblagu, Oddzial Kardiologiczny z Pododdzialem Kardiologii Inwazyjnej

location_facility: Department of Cardiology, Lyell McEwin Hospital

location_facility: Josephs-Hospital Warendorf Med. Klinik II, Kardiologie/Angiologie

location_facility: Limited Liability Company International Medical Centre SOGAZ

location_facility: State Autonomous Healthcare Institution of Yaroslavl region Clinical Emergency Hospital n.a..N.V.So

location_facility: Hospital Central "Dr. Ignacio Morones Prieto"

location_facility: Hospital Mae de Deus-Associacao Educadora de Sao Carlos-AESC/IMV - Instituto de Medicina Vascular

location_facility: Clinica Nuevas Tecnologias En Diabetes Y Endocrinologia

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie,

location_facility: Centro de Investigacion Medica Integral S.C.

location_facility: Azienda Ospedaliera Universitaria Santa Maria della Misericordia

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej Gdanskie Centrum Zdrowia, Poradnia Kardiologiczna

location_facility: Centre Hospitalier Universitaire (CHU) de Liege

location_facility: CCBR Brasil - Centro de Pesquisa e Analises Clinicas LTDA

location_facility: Black Hills Cardiovascular-Regional Health Research

location_facility: Missouri Cardiovascular Specialists, LLP

location_facility: LeBauer Cardiovascular Research Foundation

location_facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni

location_facility: Centro de Pesquisas Medicas Basica e Clinica LTDA

location_facility: Institut fuer Klinische Forschung und Entwicklung(IKFE) Berlin GmbH

location_facility: Unicare Heart Institute & Research Center

location_facility: Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders

location_facility: Federal State Budgetary Institution of Healthcare Hospital of Russian Academy of Sciences

location_facility: Daegu Catholic University Medical Center

location_facility: Saint Petersburg State Budgetary Institution of Healthcare

location_facility: Centro de Investigacion Clinica Avanzada y Multidisciplinaria CICLAM

location_facility: Northwest Houston Clinical Research, PLLC

location_facility: Southern Adelaide Diabetes and Endocrine Service

location_facility: Cardiovascular Clinical Research Institute

location_facility: Hampton Roads Center for Clinical Research

location_facility: Austin Health - Heidelberg Repatriation Hospital

location_facility: Halina Serafin NZOZ Centrum Medyczne SERAFIN-MED

location_facility: Hospital Regional Universitario de Malaga

location_facility: Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez

location_facility: INTERCARD Sp. z. o. o. Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii w Nowym Targu

location_facility: LMC Diabetes & Endocrinology (Thornhill)

location_facility: Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"

location_facility: Synexus North East Clinical Research Centre - Hexham General Hospital

location_facility: State Autonomous Healthcare Institution of Yaroslavl Region

location_facility: Hospital Universitario Virgen De La Victoria

location_facility: Heart Center, Songklanagarind Prince of Songkla University

location_facility: MUDr. Kanderkova s.r.o., Diabetologicka ambulancia

location_facility: Universidade Federal do Para - Hospital Universitario Joao de Barros Barreto

location_facility: Division Of cardiology,Department of Medicine,Faculty Of Medicine,Chulalongkorn University

location_facility: Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi

location_facility: Novant Health Heart and Vascular Institute

location_facility: Central Manchester University Hospitals NHS Foundation Trust

location_facility: Admin & Storage only:Northwest Heart Center

location_facility: Izmir Tepecik Egitim ve Arastirma Hastanesi

location_facility: Instituto de Diabetes Obesidad y Nutricion, S.C.

location_facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

location_facility: Hospital Universitario Virgen de las Nieves (HUVN)

location_facility: Doylestown Health Cardiology, a division of Doylestown Health Physicians

location_facility: Albany Medical College, Division of Community Endocrinology

location_facility: Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie

location_facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

location_facility: State Budgetary Healthcare Institution "Research Institution - Regional Clinical Hospital #1

location_facility: Loema Medicina e Bem Estar- Centro Especializado em Cardiologia Ltda.

location_facility: Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.

location_facility: CISSS des Laurentides-Point de Service de St-Jerome- Comite d'ethique de la recherche

location_facility: CARDSEARCH/CARDRESEARCH - Cardiologia Assistencial e de Pesquisa LTDA

location_facility: Moscow State Healthcare Institution "City clinical hospital n.a. S.P.Botkin"

location_facility: Philippe R. Beaudry Medicine Professional Corporation

location_facility: State Budgetary Healthcare Institution (SBHI) N.N. Burdenko Regional Clinical Hospital of Penza

location_facility: Centro De Especialidades Medicas Del Estado De Veracruz

location_facility: NZOZ "PRO CORDIS" Sopockie Centrum Badan Kardiologicznych

location_facility: Peart-Rose Research Unit, Hammersmith Hospital, Imperial College NHS Trust

location_facility: Chippenham and Johnston Willis Hospitals, Inc. dba CJW Medical Center

location_facility: Hospital Lomas de San Luis lntemacional (Emergencies)

location_facility: Clinical Research Advantage, Inc./Family Practice Specialists, Ltd.

location_facility: Cedir S.A - Centro De Diagnostico Y Rehabilitacion S.A.

location_facility: Research Institute of the Carolinas of Piedmont Healthcare, PA

location_facility: Instituto de Investigaciones Clinicas Mar del Plata

location_facility: Seoul National University Bundang Hospital

location_facility: Quanta Diagnostico e Terapia / Medicina Nuclear Alto da XV

location_facility: Regionshospitalet Silkeborg, Hjerte Projektkontor

location_facility: Women's & Family Care, LLC D.B.A. GTC Research

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD"

location_facility: SPZOZ Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Uniwersytetu Medycznego

location_facility: Austin Institute for Clinical Research,Inc.

location_facility: HealthEast St. Joseph's Hospital inpatient Pharmacy

location_facility: Nemocnice Pardubickeho kraje, a.s., Svitavska nemocnice

location_facility: Detweiler Family Medicine and Associates, PC

location_facility: Herlev Universitetshospital, Kardiologisk afdeling S

location_facility: Synexus Merseyside Clinical Research Centre

location_facility: CSK MSW w Warszawie, Klinika Kardiologii Zachowawczej i Nadcisnienia Tetniczego

location_facility: Memorial Hospital: University of Colorado Health

location_facility: Hospital Mae de Deus/Associacao Educadora Sao Carlos AESC / IMV - Instituto de Medicina Vascular

location_facility: Instituto Medico Ceniclar - Central De Investigaciones Clinicas Argentina - Sanatorio De La Mujer

location_facility: Instituto de Hematologia y Medicina Clinica "Dr. Ruben A. Davoli"

location_facility: Investigacion en Salud y Metabolismo S.C

location_facility: Canadian Centre for Research on Diabetes

location_facility: Ribo Research, LLC dba Peninsula Research

location_facility: Saint Luke's Lipid and Diabetes Research Center

location_facility: Hospital Universitario - Associacao Educadora Sao Carlos - AESC

location_facility: Synexus Scotland Clinical Research Centre

location_facility: Municipal Autonomous Institution "City Clinical Hospital #14"

location_facility: Centro Especializado En Diabetes Y Metabolismo

location_facility: Fakultni poliklinika Vseobecne fakultni nemocnice v Praze

location_facility: Mercy Health Youngstown, LLC d/b/a St. Elizabeth Youngstown Hospital

location_facility: Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #26"

location_facility: Galilee Medical Center, Cardiology Department

location_facility: Queen Elizabeth II Hospital, East and North Hertfordshire NHS Trust

location_facility: Duluth Clinic, dba Essentia Health Duluth Clinic Investigational Drug Room

location_facility: Centrum Badan Klinicznych Pi-House, Poradnia Diabetologiczna

location_facility: Heart Institute, Hillel Yaffe Medical Center

location_facility: Yonsei University Wonju Severance Christian Hospital

location_facility: Rothwell and Desborough Healthcare Group

location_facility: Research Institute of South Florida, Inc.

location_facility: Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M. Zabowka E. Zabowka

location_facility: Retreat Cardiology LLC, dba Cardiology Associates of Richmond

location_facility: Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital

location_facility: Hospital de Alta Complejidad "Pte. Juan Domingo Peron"

location_facility: Hospital Universitario Fundacion Jimenez Diaz

location_facility: Clinical Research Advantage, Inc. (Administrative Mailing Only)

location_facility: Advanced Clinical Research of Miami (ACROM) International

location_facility: Metabol KLINIK s.r.o., Ambulancia pre diabetologiu, poruchy latkovej premeny a vyzivy

location_facility: Women's & Family Care, LLC D.B.A GTC Research

location_facility: Wojewodzki Szpital Specjalistyczny we Wroclawiu, Osrodek Badawczo-Rozwojowy

location_facility: Hallym University Kangdong Sacred Heart Hospital

location_facility: Scarborough Cardiology Research Associates Inc.

location_facility: Radboud University Nijmegen Medical Centre

location_facility: Przychodnia Specjalistyczna Samodzielny Publiczny ZOZ w Rudzie Slaskiej, Poradnie Specjalistyczne,

location_facility: South Florida Clinical Research Institute

location_facility: Universitair Medisch Centrum (UMC) Utrecht - Locatie AZU

location_facility: IMC - Instituto de Molestias Cardiovasculares/Equipamentos Cardiovasculares Rio Preto Ltda

location_facility: Apex Heart Institute (A Unit of TCVS Pvt. Ltd)

location_facility: Fundación Cardiovacular de Colombia - Instituto del Corazón de Floridablanca

location_facility: Dr. Stephen Pearce Inc. & Dr. Peter K.H. Tan Inc.

location_facility: Instituto de Investigaciones Clinicas Zarate

location_facility: Abertawe Bro Morgannwg University Local Health Board Joint

location_facility: Karlkliniken, Skanes Universitetssjukhus i Malmo

location_facility: FGM-Clinica Paulista de Doencas Cardiovasculares

location_facility: The Red Porto cabin, The James Cook University Hospital

location_facility: Azienda Ospedaliera S'Andrea di Roma - UOC Cardiologia

location_facility: Vseobecna kardiologicka ambulance s.r.o.

location_facility: Aarhus Universitetshospital Skejby, Hjertesygdomme ¿ Klinisk Forskning

location_facility: Klinik fur Innere Medizin, Kardiologie und Angiologie MediClin Herzzentrum Lahr/Baden.

location_facility: Istanbul Universitesi Kardiyoloji Enstitusu

location_facility: Zala Megyei Korhaz, Diabetológiai Szakrendelés

location_facility: State Budgetary Healthcare Institution of Nizhegorodskaya Region

location_facility: Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,

location_facility: Caprock Cardiac Center Research Institute Inc.

location_facility: Pharmacy - Hospital Universitari Arnau de Vilanova (HUAV)

location_facility: National Cheng Kung University (NCKU) Hospital

location_facility: University hospitals Leuven - Neurology department

location_facility: MedStar Union Memorial Heart Specialists

location_facility: North Ohio Heart Center (Administrative Only)

location_facility: Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego

location_facility: Hospital Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: State Autonomous Healthcare Institution "Republic Clinical Hospital"

location_facility: Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiovasculares, S.C.

location_facility: Centrum Zdrowia Metabolicznego Pawel Bogdanski

location_facility: Gabinet Lekarski Malgorzata Saryusz-Wolska

location_facility: Hospital Universitario Marques De Valdecilla

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto, l.interna klinika

location_facility: Specjalistyczny Osrodek Medycyny Wieku Dojrzalego

location_facility: Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi

location_facility: Universitaets Herzzentrum Freiburg Bad Krozingen

location_facility: Hospitalsenheden Midt, Regionshospital Viborg

location_facility: CIPADI Centro Integral de Prevencion y Atencion en Diabetes

location_facility: HBA S/A ASSISTENCIA MEDICA E HOSPITALAR-Hospital da Bahia

location_facility: Clinical Research Associates of Central PA

location_facility: Synexus Lancashire Clinical Research Centre

location_facility: Charlotte Maxeke Johannesburg Academic Hospital

location_facility: The Queen Elizabeth University Hospital- NHS Greater Glasgow and Clyde

location_facility: DIKa centrum s.r.o., Kardiologicka a interni ambulance

location_facility: Cardio D&R spol.s.r.o., kardiologicka ambulancia

location_facility: Department of Neurology & Sagol Neuroscience Center

location_facility: Clinical Research Advantage, Inc. / Cassidy Medical Group - Vista

location_facility: Cardiovascular Research Center of South Florida

location_facility: Centro de Pesquisas em Diabetes e Doencas Endocrino-Metabolicas Ltda

location_facility: Pharmacology International Research, Inc.

location_facility: Pharmacology and Clinical Research S.A. de C.V.

location_facility: Cicemo - Consultorio de Investigaciones Clinicas E.M.O. S.R.L.

location_facility: Federal State Budgetary Institution "Central Clinical Hospital with Polyclinic"

location_facility: Dipartimento delle Patologie Emergenti, Unita di Medicina Interna e Dislipidemie Genetiche

location_facility: Investigational Product Shipment Address TO: Investigational Drug Services (IDS),

location_facility: Hudson Valley Cardiovascular Practice, PC

location_facility: Zentrum Klinische Studien Neuwied (ZKSN)

location_facility: Clinique des maladies lipidiques de Quebec

location_facility: "Prywatny Gabinet Kardiologiczny" Dr N.Med. Maciej Kosmider

location_facility: Bochum Research Centre-Synexus Clinical Research GmbH

location_facility: Bogna Gabrylewicz Andrzej Ochala Unimed s.c.

location_facility: The Catholic University Of Korea Seoul St.Marys Hospital

location_facility: Hospital General Universitario de Alicante; Servicio Cardiologia

location_facility: "Prof. Dr. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases,

location_facility: Egyesitett Szent Istvan Korhaz es Szent Laszlo Korhaz

location_facility: Clinical Research Advantage,Inc./Medical and Procedural Specilaists of Illinois

location_facility: State Budgetary Healthcare Institution ¿Region Clinical Hospital #3¿

location_facility: Optimamed Specjalistyczne Gabinety Lekarskie

location_facility: Centre integre de sante et de services sociaux de Lanaudiere (CISSSL)

location_facility: Gottsegen Gyorgy Orszagos Kardiologiai Intezet

location_facility: Narodny Endokrinologicky A Diabetologicky Ustav N.O.

location_facility: MetroWest Medical Center - Pharmacy Department

location_facility: 1st Pavlov State Medical University of St. Petersburg

location_facility: Pfuetzner Science & Health Institute-Gmbh

location_facility: Solano & Terront Servicios Medicos Ltda-Establecimiento Comercial UNIENDO

location_facility: Instituto de Investigacion Endocrinologia y Prevencion Metabolica - ENDOCARE LTDA.

location_facility: Altamira Family Medicine And Research Institute

location_facility: Private Practice 'Cardiovascular Detection Center'

location_facility: Wake Forest University Health Sciences Institutional Review Board

location_facility: Centro Cientifico Asistencial Jose Luis Accini S.A.S.

location_facility: Hospital Universitario Virgen de la Victoria. CE San Jose Obrero

location_facility: The Heart & Vascular Institute of Florida

location_facility: Arizona Endocrine and Rheumatology Associates

location_facility: IKF Institut fuer klinische Forschung Frankfurt

location_facility: Roodepoort Medicross Clinical Research Centre

location_facility: Universitatsklinikum des Saarlandes Klinik fur Innere Medizin III

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie,

location_facility: Hospital Inovamed Cuernavaca (Emergencies)

location_facility: Wits Clinical Research-Chris Hani Baragwanath Hospital

location_facility: Indywidualna Specjalistyczna Praktyka Lekarska Malgorzata Biedrzycka

location_facility: CRI Centro Regiomontano de Investigacion SC

location_facility: Dr. Kapil M. Bhagirath Medical Services Corporation

location_facility: Podlaski Osrodek Kardiologii Janusz Korecki

location_facility: CARDIO D&R s.r.o., Kardiologicka ambulancia

location_facility: State Budgetary Institution of Healthcare of Novosibirsk region City Clinical Hospital of Emergency

location_facility: MedStar Chesapeake CardioVascular Associates

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto

location_facility: The Royal Liverpool and Broadgreen -University Hospitals NHS

location_facility: Hospital General Universitario Morales Meseguer

location_facility: Klinika hematologie a transfuziologie, Univerzitna nemocnica Martin

location_facility: Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)

location_facility: MEDI M&M s.r.o., Ambulancia vnutorneho lekarstva

location_facility: BKS Research Kft., Albert Schweitzer Korhaz

location_facility: Ben Yair Community Clinic - Clalit Health Services

location_facility: New Orleans Center for Clinical Research

location_facility: Lillehei Clinical Research Unit, University of Minnesota

location_facility: Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.

location_facility: State Budgetary Educational Institution of Highest Professional Education

location_facility: T. Joseph Raoof, Md, Inc/Encino Research Center

location_facility: University Hospital Brussels - Centrum voor hart- en vaatziekten

location_facility: Heart of England NHS Foundation Trust, Dept. of Clinical Biochemistry & Immunology

location_facility: Metabolic and Atherosclerosis Research Center

location_facility: South Texas Cardiovascular Consultants, PLLC

location_facility: Gemeinschaftspraxis fuer Kardiologie Dres. Med. Willgeroth/Wetzel

location_facility: State Budgetary Educational Institution of Higher Professional Education

location_facility: Hospital Universitari de Tarragona Joan XXIII

location_facility: Mid-Cumberland Infectious Disease Consultants, PLC

location_facility: Medica Pro Familia Sp. z o.o. Spolka Komandytowo Akcyjna, Oddzial w Gdyni

location_facility: Peterborough and Stamford Hospitals NHS Foundation Trust

location_facility: Hopital Cardiovasculaire Et Pneumologique Louis Pradel

location_facility: Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Spolka Jawna

location_facility: SC Centrul Medical Policlinico Di Monza SRL, Cardiologie

location_facility: Specjalistyczny Osrodek Leczniczo-Badawczy Zbigniew Zegota

location_facility: CAP Disset De Setembre (Sant Cosme I Sant Damia)

location_facility: MetroWest Medical Center Research Clinic

location_facility: Centre Hospitalier Universitaire de Sherbrooke - Hotel-Dieu

location_facility: CCDHB, Wellington Hospital, Clinical Measurement Unit

location_facility: Clinical Investigation Specialists, Inc.

location_facility: S.C. Centrul Medical "Sanatatea Ta" S.R.L.

location_facility: St. Joseph Mercy Health System (Drug shipment Only)

location_facility: PMG Research,Inc d/b/a PMG Research of Knoxville

location_facility: Complejo Hospitalario Universitario de Albacete

location_facility: Dr. Anil K. Gupta Medicine Professional Corporation

location_facility: Gemeinschaftspraxis Dres. Dirk Weber, Ulrich Weber, Heiner Saueressig, Birte Turner und Georg

location_facility: Grand View - Lehigh Valley Health Services, Buxmont Cardiology Division

location_facility: Klinikum fuer Herz- & Kreislauferkrankungen

location_facility: Federal State Budgetary Institution "Advisory Diagnostic Center and Polyclinic"

location_facility: Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First

location_facility: Saint-Petersburg State Budgetary Institution of Healthcare "City Hospital #23"

location_facility: Dr. Mohan Babapulle Medicine Professional Cooperation

location_facility: Medizinisches Versorgungszentrum am Bahnhof Spandau

location_facility: McGlone Practice - Ballieston Health Centre

location_facility: Recep Tayyip Erdogan University School of Medicine, Training & Research Hospital

location_facility: DRK Kliniken Kopenick, Zentrum Klinische Forschung

location_facility: Klinik am See Rehabilitationszentrum fur Innere Medizin

location_facility: Regional Budgetary Healthcare Institution "Kursk City Clinical Emergency Hospital"

location_facility: Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddzial Szybkiej Diagnostyki

location_facility: A.karahisar Kocatepe Universitesi Hastanesi Ahmet Needet Sezer Uygulama ve

location_facility: Intercoastal Medical Group (Drug Shipment Address and Administrative)

location_facility: Univerzitna nemocnica Bmtislava, Nemocnica Stare Mesto

location_facility: Westside Medical Associates of Los Angeles

location_facility: NZOZ Przychodnia Specjalistyczna Andrzej wittek Henryk Rudzki S.C.

location_facility: Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak, III. Belgyogyaszat-Kardiologiai Osztaly

location_facility: Gaziantep Universitesi Tip Fakultesi Sahinbey Egitim ve Arastirma Hastanesi

location_facility: Specjalistyczne Gabinety Lekarskie "Medicor Plus" - Jerzy Kopaczewski

location_facility: Saint-Petersburg State Budgetary Healthcare Institution "City Hospital #15"

location_facility: Complexo Hospitalario Universitario Arquitecto Marcide-Profesor Novoa Santos De Ferrol

location_facility: AOUI di Verona - Ospedale Civile Maggiore Borgo Trento

location_facility: Unidad De Investigacion En Salud De Chihuahua S.C.

location_facility: Rutgers Biomedical and Health Sciences-Robert Wood Johnson Medical School

location_facility: Women's & Family Care D.B.A. GTC Research

location_facility: County Emergency Hospital Satu Mare Diabetes, Nutrition And Metabolic Diseases Department

location_facility: State Budget Institution of Healthcare (SBIH) of Moscow "City Clinical Hospital #81

location_facility: Ospedale Santa Maria della Misericordia Azienda ULSS 18 of Rovigo

location_facility: Consultorio de Endocrinologia y Nutriologia

location_facility: University Hospital Brussels- Diabeteskliniek

location_facility: Cardiovascular Research Institute of Dallas

location_facility: Clinresco Centres (Pty) Ltd-Central Professional Suits

location_facility: Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Diabet Zaharat, Nutritie si Boli Metabolice

location_facility: Shuali Community Clinic, Clalit Health Services

location_facility: Arcturus Healthcare, PLC, Troy Internal Medicine Research Division

location_facility: Centro de Investigaciones Clinicas "Instituto del Corazon"

location_facility: FSBEI of HE "Yaroslavl State Medical University" MH of the Russian Federation based on Clinical

location_facility: Synexus Manchester Clinical Research Centre-Manchester Science Park

location_facility: Helsingin yliopistollinen keskussairaala, Sisaetaudit ja kuntoutus, Biomedicum 2U

location_facility: Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL, Medicina Interna

location_facility: Non-State Institution of Healthcare "Central Clinical Hospital #6 OAO "RZhD"

location_facility: Centro de Diagnostico Cardiologico LTDA.

location_facility: Austin Institute for Clinical Research, Inc.

location_facility: Department of Clinical Medicines and Cardiovascular Sciences, Universita "Federico II" di Napoli

location_facility: UN Bratislava, Nemocnica Ruzinov, V. interna klinika LFUK a UN Bratislava

location_facility: Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet

location_facility: Centro De Investigaciones Clinicas Del Litoral S.R.L.

location_facility: Dip Medicina Interna e Specialita Mediche, Policlinico Umberto I

location_facility: The Lindner Center for Research and Education at The Christ Hospital

location_facility: Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

location_facility: Hospital General Universitario de Valencia

location_facility: Hospital Del Pacifico,Centro De Investigacion Clinica Del Pacifico Cicpa,Torre Medica Del Pacifico

location_facility: Dr. Pop Calin Florin - Cabinet Cardiologie

location_facility: Clinical and Translation Research Center (CTRC) University Medical Center of New Orleans, Diagnostic

location_facility: Brian Y.L. Wong Medicine Professional Corporation

location_facility: DIAMEL, s.r.o., Diabetologicka ambulancia

location_facility: Kaplan Medical Center Metabolism and Diabetes Clinic, Kaplan Medical Center

location_facility: Unità Operativa Solventi e Unità Poliambulatorio

location_facility: Dr JM Engelbrecht Trial Site-Vergelegen Mediclinic

location_facility: Kocaeli University School Of Medicine-Kocaeli Universitesi Tip Fakultesi

location_facility: ILAIM Instituto Latinoamericano de Investigaciones Medicas

location_facility: "Tyumen Cardiology Center" Affiliate of the FSBSI "Scientific and Research Institution of Cardiology

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu,

location_facility: Centro de Medicina del Ejercicio y Rehabilitacion Cardiaca S.A. CEMDE S.A.

location_facility: Irmandade Santa Casa de Misericordia de Porto Alegre

location_facility: St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare

location_facility: Region Sjaelland Sygehus Nord, Koge Sygehus

location_facility: Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.