title: A Randomized Phase 3 Study of Sitravatinib in Combination With Nivolumab Versus Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer With Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy SAPPHIRE

acronym: SAPPHIRE

summary: This study will compare the efficacy of the investigational agent sitravatinib in combination with nivolumab versus docetaxel in patients with advanced non-squamous NSCLC who have previously experienced disease progression on or after platinum-based chemotherapy and checkpoint inhibitor therapy.

location_country:
Spain
Italy
United Kingdom
Netherlands
Canada
Switzerland
Hungary
United States
France
Israel
Belgium
Germany

location_facility: Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"

location_facility: Kansas City Care Health Center - Research Medical Campus

location_facility: Hospital Clínico Universitario de Santiago de Compostela

location_facility: SCRI - Florida Cancer Specialists - North Region Research Office

location_facility: The Oncology Institute of Hope and Innovation - Tucson

location_facility: Semmelweis Egyetem - Pulmonológiai Klinika

location_facility: University Hospitals of Leicester NHS Trust

location_facility: University of California Los Angeles - Jonsson Comprehensive Cancer Center

location_facility: Amsterdam Universitair Medische Centra - Vrije Universiteit Medisch Centrum

location_facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz - III. Medizinischen Klinik und Poliklinik

location_facility: Park Nicollet - Frauenshuh Cancer Center

location_facility: Maryland Oncology Hematology - Rockville Aquilino Cancer Center

location_facility: Summit Medical Group - Florham Park Campus

location_facility: Indiana University Health Arnett Cancer Care

location_facility: Froedtert Hospital - Medical College of Wisconsin

location_facility: The Richard and Annette Bloch Cancer Care Pavilion and Westwood Medical Pavilion

location_facility: Rouen University Hôpital Charles-Nicolle

location_facility: Complejo Hospitalario Universitario A Coruña

location_facility: SCRI - Florida Cancer Specialists - West Palm Beach

location_facility: SCRI - Tennessee Oncology - Nashville - Centennial

location_facility: SCRI - Florida Cancer Specialists - Panhandle Research Office

location_facility: Michael and Dianne Bienes Comprehensive Cancer Center

location_facility: Providence Cancer Institute Franz Clinic

location_facility: University Cancer and Blood Center - LLC - Athens

location_facility: Texas Oncology - Beaumont Mamie Mcfaddin Ward Cancer Center

location_facility: MultiCare Institute for Research & Innovation

location_facility: Florida Cancer Affiliates - Ocala - Main

location_facility: Regional Cancer Care Associates - Little Silver

location_facility: Texas Oncology - Baylor Charles A. Sammons Cancer Center

location_facility: Istituto Nazionale Tumori IRCCS Fondazione G. Pascale

location_facility: IRCCS Istituto Tumori "Giovanni Paolo II"

location_facility: Northwest Georgia Oncology Centers - Marietta

location_facility: Palo Verde Cancer Specialists - Glendale

location_facility: The Center for Cancer & Blood Disorders - Fort Worth

location_facility: University Wisconsin Carbone Cancer Center

location_facility: Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne

location_facility: Los Angeles Hematology Oncology Medical Group

location_facility: ASST-SETTE LAGHI, Ospedale di Circolo e Fondazione Macchi

location_facility: NEA Baptist Fowler Family Center for Cancer Care

location_facility: Eastern Connecticut Hematology and Oncology Associates

location_facility: The Ohio State University College of Medicine

location_facility: Virginia Cancer Institute - Reynolds Crossing

location_facility: California Cancer Associates for Research and Excellence - San Marcos

location_facility: Hospital Universitario Fundación Jiménez Díaz

location_facility: Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office

location_facility: Országos Korányi Tbc És Pulmonológiai Intézet

location_facility: Hospital Universitario Insular de Gran Canaria

location_facility: Torrance Memorial Physician Network - Cancer Care and Infusion Center

location_facility: Texas Oncology - Dallas Presbyterian Hospital

location_facility: Institut de Cancérologie Strasbourg Europe

location_facility: Centre Hospitalier Universitaire Vaudois

location_facility: Azienda Ospedaliero-Universitaria di Parma

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

location_facility: Saint Joseph Heritage Healthcare - Virginia K. Crosson Cancer Center

location_facility: Sisters of Charity of Leavenworth Health St. Mary's

location_facility: Fundacion Instituto Valenciano de Oncologia

location_facility: Tricounty Hematology and Oncology- Massillon

location_facility: Institut Universitaire de Cardiologie et de Pneumologie de Québec-Universite Laval

location_facility: The Oncology Institute of Hope and Innovation - Whittier

location_facility: Klinikum rechts der Isar der Technischen Universität München

location_facility: Hospital Universitari i Politècnic La Fe

location_facility: Mercy Clinic Oncology and Hematology - Coletta

location_facility: Pontchartrain Cancer Center - Covington Office

location_facility: Azienda Ospedaliero - Universitaria Pisana

location_facility: Hospital Regional Universitario de Málaga - Hospital Civil

location_facility: Martha-Maria Krankenhaus Halle-Dölau gGmbH, Studiensekretariat

location_facility: USOR - Consultants in Medical Oncology and Hematology PC - Abington Hematology/Oncology Associates

location_facility: The Oncology Institute of Hope and Innovation - Corona

location_facility: Hospital Universitario Puerta de Hierro - Majadahonda

location_facility: Florida Cancer Specialists & Research Institute

location_facility: Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo

location_facility: Hospital Alvaro Cunqueiro - Clinico Universitario Vigo

location_facility: Texas Oncology - Methodist Dallas Cancer Center

location_facility: Horizon Health Network - The Moncton Hospital

location_facility: Klinikverbund Kempten-Oberallgäu - Klinik Immenstadt - Klinikverbund Allgäu gGmbH

location_facility: S.C Oncologia Medica, ASST Monza - Ospedale San Gerardo

location_facility: Institut Català d'Oncologia Badalona, Hospital Universitari Germans Trias i Puj

location_facility: Centre Hospitalier Universitaire Limoges

location_facility: Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec

location_facility: Hospital Universitario Central de Asturias

location_facility: Comprehensive Blood and Cancer Center - Bakersfield

location_facility: Hematology Oncology Associates of Fredericksburg

location_facility: Centre Hospitalier Intercommunal de Créteil

location_facility: Institut Régional du Cancer de Montpellier - Val d'Aurelle

location_facility: The Oncology Institute of Hope and Innovation - Thousand Oaks

location_facility: Oregon Health and Science University Knight Cancer Institute

location_facility: Windsor Regional Hospital Cancer Program


type: Other Identifier

type: Registry Identifier

type: EudraCT Number

title: A Phase 3, Randomized, Double-blind Study to Compare the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Lenvatinib (E7080/MK-7902) Versus Pembrolizumab and Placebo as First Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma in Cisplatin-ineligible Participants Whose Tumors Express PD-L1, and in Participants Ineligible for Any Platinum-containing Chemotherapy Regardless of PD-L1 Expression (LEAP-011)

summary:
The purpose of this study is to evaluate the efficacy and safety of lenvatinib (MK-7902/E7080) in combination with pembrolizumab (MK-3475) in the treatment of cisplatin-ineligible participants with a Programmed Cell Death-Ligand 1 (PD-L1) Combined Positive Score (CPS) ≥10, or in participants ineligible for any platinum-containing chemotherapy regardless of CPS, with advanced/unresectable or metastatic urothelial carcinoma (UC).

The primary hypotheses for this study are that:

Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR), and
Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Overall Survival (OS).

With Amendment 3 study treatment with lenvatinib and placebo was discontinued and all participants were unblinded and continued treatment with pembrolizumab monotherapy only. The pembrolizumab+lenvatinib and the pembrolizumab+placebo arms are no longer active for this study.

With Amendment 3 the external Data Monitoring Committee was discontinued.

study_start_date_type: Actual

status: Active, not recruiting

study_completion_date_type: Anticipated

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Anticipated

ReferenceType: derived

ReferenceCitation: Taylor MH, Schmidt EV, Dutcus C, Pinheiro EM, Funahashi Y, Lubiniecki G, Rasco D. The LEAP program: lenvatinib plus pembrolizumab for the treatment of advanced solid tumors. Future Oncol. 2021 Feb;17(6):637-648. doi: 10.2217/fon-2020-0937. Epub 2020 Dec 10.

ipd_sharing: Yes

lead_sponsor: Merck Sharp & Dohme LLC

location_country:
Denmark
Poland
Taiwan
Spain
Italy
Russian Federation
Australia
Netherlands
Argentina
Canada
United Kingdom
Hungary
Korea, Republic of
United States
France
China
Israel
Turkey
Japan
Germany

location_facility: Sun Yat-Sen University Cancer Center ( Site 0752)

location_facility: Institut de Cancerologie Strasbourg Europe ( Site 0232)

location_facility: Orszagos Onkologiai Intezet ( Site 0503)

location_facility: Chungnam National University Hospital ( Site 0195)

location_facility: Kaohsiung Chang Gung Memorial Hospital ( Site 0217)

location_facility: Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0216)

location_facility: Peking University Third Hospital ( Site 0727)

location_facility: Comprehensive Cancer Centers of Nevada ( Site 0005)

location_facility: Thomas Jefferson University Hospital ( Site 0051)

location_facility: Seattle Cancer Care Alliance ( Site 0003)

location_facility: Mercy Hospital Saint Louis - David C. Pratt Cancer Center ( Site 0095)

location_facility: Korea University Anam Hospital ( Site 0197)

location_facility: Centre de Cancerologie du Grand Montpellier ( Site 0249)

location_facility: Hospital Universitario HM Sanchinarro ( Site 0356)

location_facility: Istituto Tumori Giovanni Paolo II ( Site 0306)

location_facility: Zhejiang Provincial People's Hospital ( Site 0735)

location_facility: Shaare Zedek Medical Center ( Site 0559)

location_facility: China Medical University Hospital ( Site 0213)

location_facility: Europejskie Centrum Zdrowia Otwock ( Site 0532)

location_facility: CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0102)

location_facility: Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0277)

location_facility: Ospedale San Raffaele-Oncologia Medica ( Site 0309)

location_facility: Azienda Ospedaliera per l Emergenza Cannizzaro ( Site 0305)

location_facility: Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0101)

location_facility: Assaf Harofeh Medical Center ( Site 0556)

location_facility: Russian Scientific Center of Roentgenoradiology ( Site 0424)

location_facility: Maastricht Universitair Medisch Centrum - MUMC ( Site 0334)

location_facility: University of California Irvine Medical Center ( Site 0078)

location_facility: Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0504)

location_facility: Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 0378)

location_facility: Antalya Memorial Hospital Department of Medical Oncology ( Site 0461)

location_facility: Medical Hospital, Tokyo Medical And Dental University ( Site 0130)

location_facility: Aarhus Universitets hospital ( Site 0683)

location_facility: Universitaetsklinikum Essen ( Site 0274)

location_facility: Medical University of South Carolina-Hollings Cancer Center ( Site 0029)

location_facility: The First Affiliated Hospital of Xi an Jiaotong University ( Site 0738)

location_facility: Centro di Riferimento Oncologico CRO ( Site 0304)

location_facility: Yamaguchi University Hospital ( Site 0135)

location_facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0454)

location_facility: Northwest Georgia Oncology Centers PC ( Site 0707)

location_facility: Harbin Medical University Cancer Hospital ( Site 0750)

location_facility: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ( Site 0746)

location_facility: Centro Oncológico de Rosario ( Site 0584)

location_facility: Nara Medical University Hospital ( Site 0133)

location_facility: Sunnybrook Research Institute ( Site 0106)

location_facility: Staedtisches Krankenhaus Kiel GmbH ( Site 0285)

location_facility: Saitama Medical University International Medical Center ( Site 0125)

location_facility: Centre Hospitalier de la Cote Basque ( Site 0239)

location_facility: Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0351)

location_facility: Taichung Veterans General Hospital ( Site 0214)

location_facility: Nottingham University Hospital NHS Trust ( Site 0383)

location_facility: Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0774)

location_facility: CHU de Bordeaux- Hopital Saint Andre ( Site 0235)

location_facility: Chonnam National University Hwasun Hospital ( Site 0194)

location_facility: Hospital Teresa Herrera - Chuac ( Site 0357)

location_facility: University of Tsukuba Hospital ( Site 0126)

location_facility: Azienda Ospedaliera Santa Maria ( Site 0303)

location_facility: Sapporo Medical University Hospital ( Site 0122)

location_facility: Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0459)

location_facility: Nanjing Drum Tower Hospital ( Site 0737)

location_facility: Central Clinical Hospital with Polyclinic ( Site 0415)

location_facility: Second Affiliated Hospital, Zhejiang University ( Site 0734)

location_facility: GBUZ Leningrad Regional Clinical Oncology Dispensary ( Site 0426)

location_facility: Nagasaki University Hospital ( Site 0136)

location_facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0002)

location_facility: Aalborg Universitets Hospital ( Site 0684)

location_facility: Peking University First Hospital ( Site 0726)

location_facility: The First Affiliated Hospital of Xiamen University ( Site 0743)

location_facility: Tokushima University Hospital ( Site 0134)

location_facility: Clinical Hospital Saint Luka ( Site 0421)

location_facility: Austin Health-Austin Hospital ( Site 0154)

location_facility: Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0577)

location_facility: CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0104)

location_facility: Queens Hospital-Purple Zone ( Site 0377)

location_facility: University College London Hospital NHS Foundation Trust ( Site 0380)

location_facility: Urologica Praktyka Lekarska Adam Marcheluk ( Site 0543)

location_facility: Odense Universitetshospital ( Site 0682)

location_facility: Helios Kliniken Schwerin GmbH ( Site 0278)

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0301)

location_facility: Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0507)

location_facility: Veterans Health Service Medical Center ( Site 0198)

location_facility: Volga District Medical Center Federal Medical and Biological Agency ( Site 0413)

location_facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 0535)

location_facility: Murmansk Regional Oncology Dispensary ( Site 0420)

location_facility: Instituto de Investigaciones Metabolicas ( Site 0589)

location_facility: ASST Grande Ospedale Metropolitano Niguarda ( Site 0307)

location_facility: Omsk Clinical Oncology Dispensary ( Site 0418)

location_facility: Hospital General Universitari Vall d Hebron ( Site 0358)

location_facility: Peninsula Health Frankston Hospital ( Site 0153)

location_facility: The First Affiliated Hospital of Guangzhou Medical University ( Site 0749)

location_facility: Osaka City University Hospital ( Site 0132)

location_facility: Universitaetsklinikum Hamburg-Eppendorf ( Site 0282)

location_facility: National Cheng Kung University Hospital ( Site 0215)

location_facility: National Cancer Center Hospital East ( Site 0128)

location_facility: Ospedale Borgo Roma-Oncologia ( Site 0308)

location_facility: Hirosaki University Hospital ( Site 0123)

location_facility: Zhongshan Hospital Fudan University ( Site 0725)

location_facility: Luxmed Onkologia sp. z o. o. ( Site 0541)

location_facility: Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi ( Site 0457)

location_facility: New England Cancer Specialists ( Site 0047)

location_facility: Policlinico S. Orsola - Malpighi (Bologna) ( Site 0302)

location_facility: Banner MD Anderson Cancer Center ( Site 0016)

location_facility: Ege Universitesi Tulay Aktas Onkoloji Hastanesi ( Site 0462)

location_facility: Royal Stoke University Hospital Univ. Hosps of North Midlands NHST ( Site 0392)

location_facility: Centre D Oncologie de Gentilly ( Site 0240)

location_facility: Sakarya Universitesi Tip Fakultesi Arastirma Hastanesi ( Site 0460)

location_facility: Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0236)

location_facility: John Wayne Cancer Institute ( Site 0017)

location_facility: Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0456)

location_facility: Saint Bartholomew s Hospital - London ( Site 0386)

location_facility: Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0585)

location_facility: Fifth Medical Center of CPLA General Hospital ( Site 0732)

location_facility: Cancer Hospital Affiliated to Xinjiang Medical University ( Site 0751)

location_facility: Taipei Veterans General Hospital ( Site 0212)

location_facility: Medical Rehabilitation Center ( Site 0411)

location_facility: Centro Oncologico de Integracion Regional. COIR ( Site 0576)

location_facility: Universitaetsklinikum Giessen und Marburg GmbH ( Site 0284)

location_facility: Hospital Universitario Gregorio Maranon ( Site 0352)

location_facility: Universitaetsmedizin Goettingen ( Site 0281)

location_facility: Kitasato University Hospital ( Site 0129)

location_facility: Kent and Canterbury Hospital ( Site 0390)

location_facility: Seoul National University Hospital ( Site 0191)

location_facility: Baylor Scott & White Medical Center - Temple ( Site 0706)

location_facility: Markusovszky Egyetemi Oktatokorhaz ( Site 0502)

location_facility: Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0271)

location_facility: Hadassah Ein Kerem Medical Center ( Site 0558)

location_facility: Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce

location_facility: Fudan University Shanghai Cancer Center ( Site 0721)

location_facility: Szpital Miejski im. Jana Pawła II w Bielsku-Białej ( Site 0542)

location_facility: CHD Vendee-onco-hematologie ( Site 0251)

location_facility: Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 0509)

location_facility: National Taiwan University Hospital ( Site 0211)

location_facility: St. Peter's Hospital Cancer Care Center ( Site 0042)

location_facility: Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 0414)

location_facility: Xarxa Assistencial Universitaria Manresa ( Site 0354)

location_facility: Instituto Medico Alexander Fleming ( Site 0578)

intervention_type: Biological

lead_sponsor_type: industriel

status_simplified: Ongoing


title: A Phase 3b, Randomized, Double-blind Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Monotherapy for Patients With Previously Untreated Advanced Renal Cell Carcinoma and Intermediate- or Poor-Risk Factors

lead_sponsor: Bristol-Myers Squibb

source: euctr

ipd_sharing_description: Individual patient level data from this study may be shared with qualified researchers, upon request, following the timelines and process detailed on https://www.bms.com/researchers-and-partners/independent-research/data-sharing-request-process.html

enrollment_type: Actual

location_country:
Poland
Portugal
Romania
Spain
Greece
Austria
Italy
Russian Federation
Argentina
United States
Chile
France
Mexico
Czechia

location_facility: Radioterapeuticka a onkologicka klinika FNKV

location_facility: Charleston Hematology Oncology Associates, Pa

location_facility: Massachusetts General Hospital Cancer Center Yawkey 7E

summary: The purpose of this study is to test the effectiveness and safety of nivolumab combined with ipilimumab compared to nivolumab monotherapy in participants with previously untreated kidney cancer that has spread.


title: A Randomized Double-blind Placebo-controlled Multicenter Phase 3 Study of Efficacy and Safety of AR-301 as Adjunct Therapy to Antibiotics in the Treatment of Ventilator-Associated Pneumonia (VAP) Caused by S. Aureus

summary: AR-301 is being evaluated as an adjunctive treatment of ventilator-associated pneumonia (VAP) due to Staphylococcus aureus (S. aureus) in combination with standard of care (SOC) antibiotic therapy in patients with confirmed S. aureus infection.

status: Recruiting

ipd_sharing: No

lead_sponsor: Aridis Pharmaceuticals, Inc.

location_country:
Taiwan
Brazil
Belarus
Serbia
Latvia
Georgia
Estonia
Mexico
Russian Federation
Ukraine
Philippines
United States
France
China
India
Belgium
Israel
South Africa
Turkey

location_facility: Kharkiv City Clinical Hospital No 2 n.a. prof. O.O.Shalimov

location_facility: Clinical Center of Serbia_Clinic for Digestive Surgery

location_facility: Railway Clinical Hospital on Station Chelyabinsk of JSC Russian Railways

location_facility: СHRU de Nîmes -Hôpital Carémeau-Service des Réanimations

location_facility: CHRU de Lille-Urgence Respiratoire et Réanimation Médicale

location_facility: Clinical-Hospital Centre Bezanijska Kosa - Pulmonology Department

location_facility: Riga East Clinical University Hospital Clinic "Gailezers"

location_facility: linical Center Kragujevac Center for Anaesthesiology and Reanimation

intervention_type: Other


title: A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 2)

acronym: LUCENT 2

summary: The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed as clinical responders in the prior 12-week induction study LUCENT-1 (NCT03518086).

ipd_sharing_description: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

lead_sponsor: Eli Lilly and Company

location_country:
Serbia
Spain
Italy
United Kingdom
Lithuania
Ukraine
United States
Belgium
Japan
Romania
Czechia
Poland
Austria
Australia
Russian Federation
Argentina
India
Israel
Turkey
Mexico
Malaysia
Slovakia
Canada
Switzerland
Hungary
China
Germany
Denmark
Taiwan
Ireland
Latvia
Korea, Republic of
France
Netherlands

location_facility: Acibadem Universitesi - Acibadem Kozyatagi Hastanesi

location_facility: Jiangsu Province Hospital of Chinese Medicine

location_facility: Nizhny Novgorod Regional Hospital N.A. Semashko

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital

location_facility: Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -

location_facility: Melbourne Gastrointestinal Investigation Unit (MGIU)

location_facility: HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen

location_facility: M S Ramaiah Medical College and Hospitals

location_facility: CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

location_facility: Clinical Trials Center of Medical Institute

location_facility: Cotton-O'Neil Clinical Research Center, Digestive Health

location_facility: Mautalen Salud e Investigacion-Centro de Osteopatías Médicas

location_facility: Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"

location_facility: Kunming Medical College Affiliated First Hospital

location_facility: Clinical Center Kragujevac Gastroenterohepatology Clinic

location_facility: Centro Para el Desarrollo de la Medicina y de Asistencia Med

location_facility: National Hospital Organization Takasaki General Medical Centar

location_facility: Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC

location_facility: Gastroenterology Associates of Western Michigan, P.L.C.

location_facility: Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica

location_facility: Care Access Research LLC - Salt Lake City

location_facility: Gastroenterology Research of San Antonio

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika

location_facility: Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie

location_facility: Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Donato Gastroenterologia

location_facility: National Hospital Organization Hirosaki General Medical Center

location_facility: Pauls Stradins Clinical Univeristy Hospital

location_facility: National Hospital Organization Kyoto Medical Center

location_facility: Azienda ospedaliero-universitaria Mater Domini

location_facility: Saint Petersburg State Medical University n.a. Pavlov I.P.

location_facility: Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation

location_facility: State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"

location_facility: University of North Carolina Center for Inflammatory Bowel Disease

location_facility: SR Kalla Memorial Gastro & General Hospital

location_facility: Multidisciplinary Medical Clinic "Anthurium"

location_facility: Diaservis - Medical and Diagnostic Center

location_facility: Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU

location_facility: Ishida Clinic of IBD and Gastroenterology

location_facility: Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre

location_facility: Yaroslavl Municipal HI Clinical Hospital #8

location_facility: Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho

location_facility: Hospital Universitario Juan Ramon Jimenez

location_facility: The First Affiliated Hospital of Anhui Medical University

location_facility: Gastroenterology Associates of Pensacola, PA

location_facility: Center Hospital of the National Center for Global Health and Medicine

location_facility: Beijing Friendship Hospital Affiliate of Capital University

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Centro de Investigación Clínica Acelerada

location_facility: The Catholic University of Korea, Daejeon St. Mary's Hospital

location_facility: Communal Enterprise "Odesa Regional Clinical Hospital"

location_facility: Centre de santé et de services sociaux Champlain-Charles-Le Moyne

location_facility: Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2

location_facility: Hospital Privado Centro Medico de Cordoba SA

location_facility: Research Associates of South Florida, LLC

location_facility: Kocaeli University Medical Faculty Hospital

location_facility: Hopital de Hautepierre - Service d'Hépatogastroentérolgie

location_facility: Riga Eastern Clinical University Hospital

location_facility: The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA

location_facility: The University of Hong Kong-Shenzhen Hospital

location_facility: The Affiliated Hospital of Medical College Qingdao Univ

location_facility: Clinical Applications Laboratories, Inc.

location_facility: A. Novak Transcarpathian Regional Clinical Hospital

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

location_facility: Galilee Medical Center Department of Internal Medicine A

location_facility: Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"

location_facility: Policlinico Gemelli - Università Cattolica del Sacro Cuore

location_facility: Hospital Gen. Juan Ramon Jimenez - Depto de Digestivo

location_facility: The Affiliated Drum Tower Hospital of Nanjing University

location_facility: Karelia Republican Hospital V.A. Baranova

location_facility: Medical Center of Limited Liability Company "Medical Center "Consilium Medical"

location_facility: Gen1 Research - Gastroenterology & Nutrition, PC

location_facility: Azienda Ospedaliera Universitaria Policlinico de Modena

location_facility: Poona Medical Foundation. Ruby Hall Clinic

location_facility: Bangalore Medical College and Research Institute

location_facility: Shanghai Jiaotong University School of Medicine Ruijin Hospital

location_facility: Azienda Ospedaliero Universitaria San Martino

location_facility: Showa University Northern Yokohama Hospital

location_facility: Wojewodzki Specjalistyczny Szpital w Olsztynie

location_facility: Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod

location_facility: The Gordon and Leslie Diamond Health Care Centre

location_facility: Sankikai Yokohama Shin midori General Hospital

location_facility: Vilnius University Hospital Santariskiu Clinics

location_facility: The Sixth Affiliated Hospital, Sun Yat-Sen University

location_facility: Gastroenterologische Praxis Balsiger, Seibold & Partner

location_facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata

location_facility: The Second Hospital of Dalian Medical University

location_facility: Escorts Heart Institute and Research Centre Ltd

location_facility: UMC Utrecht, Dept. of Internal Medicine, MDL

location_facility: Nanjing Medical University - Nanjing Jiangning Hospital

location_facility: The First People's Hospital of Yunnan Province

location_facility: The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university

location_facility: Carolina Digestive Diseases and Endoscopy Center

location_facility: Xiangya Hospital Central South University

location_facility: Twoja Przychodnia - Szczecinskie Centrum Medyczne

location_facility: Hospital Universitario Central de Asturias

location_facility: Apollo Research and Innovations, Apollo Hospitals International Ltd

location_facility: Hospital Universitario Marqués de Valdecilla

location_facility: Scientific Centre of Reconstructive and Restorative Surgery

location_facility: Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus

location_facility: Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia

location_facility: MNGI Digestive Health - Plymouth Endoscopy Center & Clinic

location_facility: Centro de Investigaciones Médicas Tucuman

location_facility: University Medical Center "Bezanijska kosa"

location_facility: Regional Hospital Dr Radivoj Simonovic Sombor

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology

location_facility: Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

location_facility: Endomedix Diagnosztikai Központ - Miskolc

location_facility: Azienda Ospedaliera Universitaria Pisana

location_facility: Soroka Medical Center - Pediatric Outpatient Clinic

location_facility: Kitasato University Kitasato Institute Hospital

location_facility: Complexo Hospitalario Universitario A Coruña, CHUAC

location_facility: University of Oklahoma Health Sciences Center

location_facility: Municipal Non-Profit Enterprise "Lviv Clinical Emergency Care Hospital"

location_facility: Tokyo Medical and Dental University Hospital

location_facility: The First Hospital Affiliated to AMU (Southwest Hospital)

location_facility: Shengjing Hospital of China Medical University

location_facility: No.1 Hospital Affiliated to Xinjiang Medical University

location_facility: Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.

location_facility: Centro de Investigaciones Metabólicas (CINME)

location_facility: West China Hospital of Sichuan University

location_facility: Assistance Publique Hôpitaux de Marseille - Hôpital Nord

location_facility: Clinical Research Institute of Michigan, LLC

location_facility: CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro

location_facility: Centre Hospitalier de Wallonie Picarde - Site Notre Dame

location_facility: Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital

location_facility: Medical and Sanitary Division of Severstal

location_facility: The Second Affiliated Hospital of Zhejiang University School of Med

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: Renji Hospital Affliated to Shanghai Jiaotong University

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas

location_facility: Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii

location_facility: First Affiliated Hosp of College of Med, Zhejiang University

intervention_type: Drug


title: An Open-Label, Single-Arm 4-Year Study to Evaluate Effectiveness and Safety of Ocrelizumab Treatment in Patients With Progressive Multiple Sclerosis

acronym: CONSONANCE

summary: This study is a prospective, multicenter, open-label, single-arm effectiveness and safety study in participants with progressive multiple sclerosis (PMS).

ipd_sharing_description: Qualified researchers may request access to individual patient level data through the clinical study data request platform (www.clinicalstudydatarequest.com). Further details on Roche's criteria for eligible studies are available here (https://clinicalstudydatarequest.com/Study-Sponsors/Study-Sponsors-Roche.aspx). For further details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (https://www.roche.com/research_and_development/who_we_are_how_we_work/clinical_trials/our_commitment_to_data_sharing.htm).

lead_sponsor: Hoffmann-La Roche

location_country:
Spain
Italy
United States
Costa Rica
Czechia
Poland
Russian Federation
Panama
Mexico
Egypt
Bosnia and Herzegovina
Brazil
Lebanon
Canada
Guatemala
Hungary
Germany
Denmark
Ireland
France
Colombia
Netherlands
Morocco
United Arab Emirates

location_facility: Rigshospitalet; Skleroseklinikken - Glostrup

location_facility: A.O. Sant'Andrea; UOC Neurologia, Dip. di Neuroscienze, Salute Mentale e Organi di Senso (NESMOS)

location_facility: Universitätsklinikum "Carl Gustav Carus", Zentrum für Klinische Neurowissenschaften

location_facility: Washington University School of Medicine

location_facility: Hospital Notre-Dame du Centre Hospitalier de l'Universite de Montreal

location_facility: Università degli studi della Campania Luigi Vanvitelli; Dip.Ass Int Med Int-I Clinica Neurologica

location_facility: VALEOMED Diagnosztikai Központ; VALEOMED Diagnosztikai Központ

location_facility: Hopital Gabriel Montpied CHU de Clermont-Ferrand; Service de Neurologie B

location_facility: University Hospital Mostar; Neurology Clinic

location_facility: Aarhus Universitetshospital, Neurologisk Afd. F, Skleroseklinikken

location_facility: Policlinico G.B. Rossi; Dip. Scienze Neurologiche Biomediche - Neurologia B - Amb. Sclerosi Multipla

location_facility: AOU Città della Salute e della Scienza; Neurologia 1

location_facility: University of British Columbia Hospital; Division of Neurology

location_facility: Fraser Health Authority - Fraser Health Multiple Sclerosis

location_facility: Uniwersytecki Szpital Kliniczny w Bialymstoku

location_facility: IRCCS Ospedale San Raffaele; Neurologia Neurofisiologia Neuroriabilitazione-Centro Sclerosi Multipla

location_facility: Nemocnice Jihlava; NEU-Neurologicke oddeleni

location_facility: Hospital das Clínicas Faculdades Médicas de Ribeirão Preto

location_facility: Zuyderland Medisch Centrum - Sittard Geleen

location_facility: Clinical Center University of Sarajevo; Neurology clinic

location_facility: Lebanese American University Medical Center- Rizk Hospial

location_facility: Hospital das Clinicas - FMUSP_X; Neurologia

location_facility: Groupe Hospitalo-Universitaire Caremeau; Service Neurologie

location_facility: Studienzentrum Nordwest, Dr. med. Joachim Springub / Herr Wolfgang Schwarz

location_facility: Ospedale Binaghi; Centro Sclerosi Multipla

location_facility: Ospedale Cattinara; Amb Studio Sclerosi Multipla, Clinica Neurlogica

location_facility: Hopital Militaire d'Instruction Mohamed V

location_facility: Fundacion Clinica Valle del Lili; Unidad de Investigaciones Clinicas

location_facility: Wojskowy Instytut Medyczny Centralny Szpital Kliniczny MON

location_facility: Hospital Universitario la Fe; Servicio de Neurologia

location_facility: A. O. U. Federico II; Dip Neuroscienze, Scienze Riproduttive ed Odontostomatologiche

location_facility: Università degli Studi della Campania Luigi Vanvitelli; Dip. Ass. Integrato Med Int-II Clinica Neur

location_facility: American University of Beirut - Medical Center

location_facility: CHU de la Timone - Hopital d Adultes; Service de Neurologie

location_facility: Unidad de investigacion en salud (UIS); Neurociencias

location_facility: Hospital Vall d'Hebron; Servicio de Neurología

location_facility: IRCCS Istituto Neurologico Neuromed; Centro per lo Studio e la Cura della Sclerosi Multipla

location_facility: Pécsi Tudományegyetem, Klinikai Központ Neurológiai Klinika; Klinikai Központ Neurológiai Klinika

location_facility: Wayne State University School of Medicine

location_facility: University Clinical Center Tuzla; Neurology

location_facility: IRCCS Istituto Neurologico C. Mondino-Dip. Neurologia Neuroriabilitazione S.S. Sclerosi Multipla

location_facility: Centre Hospitalier Universitaire de Rennes

location_facility: NeuroPoint, Gesellschaft für vorbeugende Gesundheitspflege mbH

location_facility: Hopital Civil de Strasbourg; Service de Neurologie

location_facility: Policlinico Universitario A. Gemelli; UOC Neurologia - Centro Sclerosi Multipla

location_facility: St Vincents University Hospital; Carew House-Neurology Department

location_facility: Semmelweis Egyetem AOK; Neurologiai Klinika

location_facility: Azienda Ospedaliero Universitaria Consorziale Policlinico di; Scienze Neurologiche

location_facility: Fond. Istituto Neurologico C.Besta; UO Neurologia IV - Neuroimmunologia Malattie Neuromuscolari

location_facility: Centre Hospitalier Universitaire Hassan II

location_facility: Szpital Uniwersytecki w Krakowie; Oddział kliniczny Neurologii

location_facility: Deutsche Klinik für Diagnostik; DKD Helios Klinik Wiesbaden, Abt. Neurologie

location_facility: Vladimirskiy Regional Scientific Research Inst.

location_facility: Universitätsmedizin Greifswald; Klinik und Poliklinik für Neurologie

location_facility: University Clinical Center of the Republic of Srpska; Neurology Clinic

location_facility: Beaumont Hospital; Clinical Research and Education Centre, Smurfit Building

location_facility: Azienda Ospedaliera Sant'Andrea; UOC Neurologia

location_facility: City Clinical Hospital #24; Multipal Sclerosis department

location_facility: Azienda Sanitaria Ospedaliera S. Luigi Gonzaga; Centro Regionale Sclerosi Multipla - Neurologia II

location_facility: Hospital Universitario Virgen de Arrixaca; Servicio de Neurología

location_facility: AOU Policlinico V. Emanuele - P.O G. Rodolico; Clinica Neurologica, Centro Sclerosi Multipla

location_facility: University of Cincinnati; Department of Neurology

location_facility: Rigshospitalet; Neurologisk Klinik Glostrup

location_facility: University of Chicago; Neurology/MC 2030

location_facility: Ain Shams University Hospital; Clinical Research Center (MASRI-CRC)

location_facility: Fakultní Nemocnice Olomouc; Neurologicka Klinika

location_facility: SP Swiecickiego UM Marcinkowskiego; Od. Klin. Neurologii z podod. Udarowym

location_facility: Vseobecna fakultni nemocnice v Praze; MS Centrum, Neurologicka klinika

location_facility: Groupe Hospitalier Pellegrin; Service de Neurologie - 3ème étage

location_facility: Scientific Neurology Center; Neurological department #6

location_facility: London Health Sciences Centre Uni Campus

location_facility: Hopital neurologique Pierre Wertheimer - CHU Lyon; Neurologie

location_facility: National Center of Social Significant Disease

location_facility: Yale University Multiple Sclerosis Center

location_facility: Clinical Research Center-Alex university; Neurology Department

location_facility: AOUC Azienda Ospedaliero-Universitaria Careggi; Neurologia 2

location_facility: Hjerne- og nervesygdomme, Ambulatorium, Skleroseklinikken

location_facility: CHU De Caen; Service De Neurologie Dejerine

location_facility: Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla

location_facility: Grupo Medico de Investigacion Clinica Multidisciplinaria

location_facility: Massachusetts General Hospital; Neurological Clinical Research Institute (NCRI)


title: A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

summary: The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.

location_country:
Croatia
Serbia
Saudi Arabia
Italy
Spain
United Kingdom
Lithuania
Ukraine
United States
Belgium
Japan
Romania
Czechia
Poland
Austria
Australia
Russian Federation
Argentina
India
Israel
Turkey
Mexico
Malaysia
Slovakia
Canada
Switzerland
Hungary
China
Germany
Denmark
Taiwan
Ireland
Latvia
Korea, Republic of
France
Netherlands

location_facility: Acibadem Universitesi - Acibadem Kozyatagi Hastanesi

location_facility: Jiangsu Province Hospital of Chinese Medicine

location_facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital

location_facility: Azienda Ospedaliera Universitaria Careggi

location_facility: Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -

location_facility: Melbourne Gastrointestinal Investigation Unit (MGIU)

location_facility: Gastro I s.r.o., Gastroenterologická ambulancia

location_facility: LLC Scientific Research Centre EKO-Bezopasnost

location_facility: Pusat Perubatan University Kebangsaan Malaysia

location_facility: CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

location_facility: Clinical Trials Center of Medical Institute

location_facility: Cotton-O'Neil Clinical Research Center, Digestive Health

location_facility: KM Management spol. s r.o. Gastroenterologicke a hepatologicke centrum

location_facility: Mautalen Salud e Investigacion-Centro de Osteopatías Médicas

location_facility: DRC Gyogyszervizsgalo Rendelointezet Kft

location_facility: Center for Advanced Gastroenterology, PLLC

location_facility: NZOZ ALL-MEDICUS, Zaklad Gastroenterologii

location_facility: Tokyo Medical And Dental University Medical Hospital

location_facility: Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"

location_facility: Kunming Medical College Affiliated First Hospital

location_facility: Clinical Center Kragujevac Gastroenterohepatology Clinic

location_facility: Atlanta Gastroenterology Specialists, PC

location_facility: Centro Para el Desarrollo de la Medicina y de Asistencia Med

location_facility: Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC

location_facility: Gastroenterology Associates of Western Michigan, P.L.C.

location_facility: Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica

location_facility: Ruijin Hospital Shanghai Jiaotong University School of Medicine

location_facility: Care Access Research LLC - Salt Lake City

location_facility: Gastroenterology Research of San Antonio

location_facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika

location_facility: University of Texas Medical Branch at Galveston

location_facility: Azienda ospedaliero-universitaria Mater Domini

location_facility: Hacettepe University Faculty of Medicine

location_facility: The Catholic University of Daejeon St. Mary's Hospital

location_facility: Saint Petersburg State Medical University n.a. Pavlov I.P.

location_facility: Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation

location_facility: State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"

location_facility: Shinseikai Sai Gastroenterology, proctology

location_facility: Multidisciplinary Medical Clinic "Anthurium"

location_facility: The Center for Gastrointestinal Disorders

location_facility: Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU

location_facility: Ishida Clinic of IBD and Gastroenterology

location_facility: Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre

location_facility: The Catholic University of Korea, St. Vincent's Hospital

location_facility: Yaroslavl Municipal HI Clinical Hospital #8

location_facility: Pauls Stradins Kliniska Universitates Slimnica

location_facility: SBHI Regional Clinical Hospital #2 MoH of Krasnodar region

location_facility: The First Affiliated Hospital of Anhui Medical University

location_facility: CHU de Poitiers- Service d'Hépato-gastro-entérologie,

location_facility: Studiengesellschaft BSF Unternehmergesellschaft haftungsbeschraenkt

location_facility: Endomed, s.r.o.- Gastroenterologicka ambulancia

location_facility: Gastroenterology Associates of Pensacola, PA

location_facility: Center Hospital of the National Center for Global Health and Medicine

location_facility: Centro de Investigación Clínica Acelerada

location_facility: Communal Enterprise "Odesa Regional Clinical Hospital"

location_facility: Toho University School of Medicine, Sakura Hospital

location_facility: University of Massachusetts Medical Center

location_facility: Centre de santé et de services sociaux Champlain-Charles-Le Moyne

location_facility: NYU Langone Long Island Clinical Research Associates

location_facility: Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2

location_facility: Hospital Privado Centro Medico de Cordoba SA

location_facility: Research Associates of South Florida, LLC

location_facility: Kocaeli University Medical Faculty Hospital

location_facility: Twoja Przychodnia-Szczecinskie Centrum Medyczne

location_facility: Hopital de Hautepierre - Service d'Hépatogastroentérolgie

location_facility: Nizhegorodskiy Regional Clinical Hospital N.A.Semashko

location_facility: The Second Affiliated Hospital of Wenzhou Medical College

location_facility: Riga Eastern Clinical University Hospital

location_facility: The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA

location_facility: Pusat Penyelidikan Klinikal (CRC), Hospital Raja Perempuan Zainab II

location_facility: The University of Hong Kong-Shenzhen Hospital

location_facility: Clinical Applications Laboratories, Inc.

location_facility: A. Novak Transcarpathian Regional Clinical Hospital

location_facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

location_facility: Galilee Medical Center Department of Internal Medicine A

location_facility: Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"

location_facility: Tokushukai Sapporo Higashi Tokushukai Hospital

location_facility: Allen Whey Khye Lim Professional Corporation

location_facility: The Affiliated Drum Tower Hospital of Nanjing University

location_facility: Karelia Republican Hospital V.A. Baranova

location_facility: Wake Forest University School of Medicine

location_facility: Azienda Ospedaliera Universitaria Policlinico de Modena

location_facility: Poona Medical Foundation. Ruby Hall Clinic

location_facility: Bangalore Medical College and Research Institute

location_facility: Azienda Ospedaliero Universitaria San Martino

location_facility: Showa University Northern Yokohama Hospital

location_facility: Wojewodzki Specjalistyczny Szpital w Olsztynie

location_facility: Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: The Gordon and Leslie Diamond Health Care Centre

location_facility: Sankikai Yokohama Shin midori General Hospital

location_facility: Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona Medicina Interna

location_facility: Vilnius University Hospital Santariskiu Clinics

location_facility: The Sixth Affiliated Hospital, Sun Yat-Sen University

location_facility: Niepubliczny Zaklad Opieki Zdrowotnej SONOMED

location_facility: Samodzielny Publiczny Szpital Kliniczny nr 4

location_facility: West Central Gastroenterology d/b/a Gastro Florida

location_facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata

location_facility: The Second Hospital of Dalian Medical University

location_facility: Moscow Budgetary State Healthcare Institution City Clinical Hospital 24

location_facility: Lviv Clinical Hospital at Railway Transport of Division Healthcare Center PJSC Ukrainian Railway Sta

location_facility: Escorts Heart Institute and Research Centre Ltd

location_facility: Delta Waves Sleep Disorders and Research Center

location_facility: UMC Utrecht, Dept. of Internal Medicine, MDL

location_facility: Nanjing Medical University - Nanjing Jiangning Hospital

location_facility: The First People's Hospital of Yunnan Province

location_facility: Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej

location_facility: Xiangya Hospital Central South University

location_facility: Centre Hospitalier de Wallonie picarde - CHwapi A.S.B.L.

location_facility: Hospital Universitario Central de Asturias

location_facility: Hospital Universitario Marques De Valdecilla

location_facility: Apollo Research and Innovations, Apollo Hospitals International Ltd

location_facility: Kyungpook National University Medical Center Chilgok Hospital

location_facility: Communal Non-Commercial Enterprise of Lviv Regional Council Lviv Regional Clinical Hospital

location_facility: Charité Universitätsmedizin Berlin Campus Buch

location_facility: Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus

location_facility: Irkutsk State Medical Academy of Continuing Education

location_facility: Saint-Petersburg City Hospital of Saint Elizabeth

location_facility: Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia

location_facility: Clinical Research of West Florida, Inc. (Clearwater)

location_facility: Centrum Zdrowia Matki, Dziecka i Młodzieży (CZMDM) Przychodnie

location_facility: Digestive Health Specialists of the Southeast

location_facility: Hospital Universitario Reina Sofia Comite Etico

location_facility: Communal City Clinical Hospital of Ambulance

location_facility: Private Small Enterprise, Medical Center Pulse

location_facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology

location_facility: Univerzitna nemocnica Bratislava-Nemocnica Stare Mesteo

location_facility: Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

location_facility: Institute of Digestive and Liver Diseases

location_facility: Azienda Ospedaliera Universitaria Pisana

location_facility: SBI of Healthcare of Leningrad region "Clinical Interregional Hospital of Tosno"

location_facility: Soroka Medical Center - Pediatric Outpatient Clinic

location_facility: Kitasato University Kitasato Institute Hospital

location_facility: Complexo Hospitalario Universitario A Coruña, CHUAC

location_facility: Praxis Balsiger, Seibold & Partner und Crohn-Colitis-Zentrum

location_facility: University of Oklahoma Health Sciences Center

location_facility: Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen

location_facility: Indywidualna Specjalistyczna Praktyka Lekarska

location_facility: King Faisal Specialist Hospital & Research Center

location_facility: Instituto de Investigaciones Clinicas Quilmes

location_facility: The First Hospital Affiliated to AMU (Southwest Hospital)

location_facility: CHI Prof.O.O.Shalimov Kharkiv City Clinical Hospital #2

location_facility: No.1 Hospital Affiliated to Xinjiang Medical University

location_facility: Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.

location_facility: Centro de Investigaciones Metabólicas (CINME)

location_facility: University of Arizona, CATS Research Center

location_facility: Clinical Research Institute of Michigan, LLC

location_facility: CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro

location_facility: Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital

location_facility: Medical and Sanitary Division of Severstal

location_facility: Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine

location_facility: Communal Institution "Poltava Reg.Cl.H. n.a.M.V.Sklifosovskogo"

location_facility: The Second Affiliated Hospital of Zhejiang University School of Med

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: Doctors Hospital at Renaissance Research Institute

location_facility: Renji Hospital Affliated to Shanghai Jiaotong University

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas

location_facility: Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii

location_facility: First Affiliated Hosp of College of Med, Zhejiang University


acronym: CUPISCO

title: A Phase II, Randomized, Active-Controlled, Multi-Center Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Guided by Genomic Profiling Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site Who Have Received Three Cycles of Platinum Doublet Chemotherapy

location_country:
Croatia
Spain
Italy
United Kingdom
Kazakhstan
Peru
Romania
Japan
Czechia
Poland
Portugal
Austria
Australia
Israel
Turkey
Mexico
Norway
Cyprus
Brazil
Switzerland
Hungary
Germany
Bulgaria
Denmark
Greece
Ireland
Estonia
Latvia
Finland
Thailand
Korea, Republic of
France
Chile
Colombia
Netherlands

location_facility: Tampere University Hospital; Dept of Oncology

location_facility: Klinikum der LMU München, Campus Großhadern, Krebszentrum München; Comprehensive Cancer Center LMU

location_facility: IPO do Porto; Servico de Oncologia Medica

location_facility: Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología

location_facility: Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology

location_facility: Istituto Nazionale Tumori Fondazione G. Pascale

location_facility: Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika

location_facility: North Estonia Medical Centre, Oncology and hematology Clinic; Department of Chemotherapy

location_facility: Universitätsklinikum Hamburg-Eppendorf, Onkologisches Zentrum, Studienzentrale der II. Med. Klinik

location_facility: Kazakh Scientific Research Institution Of Oncology and Radiology; Chemotherapy department

location_facility: Institut Catala d Oncologia Hospital Duran i Reynals

location_facility: Royal United Hospital; Oncology Department

location_facility: Fakultni nemocnice Olomouc; Onkologicka klinika

location_facility: Hospital Ramon y Cajal; Servicio de Oncologia

location_facility: UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie

location_facility: Asst Papa Giovanni XXIII; Oncologia Medica

location_facility: National Hospital Organization Shikoku Cancer Center

location_facility: Irccs Ospedale San Raffaele;Oncologia Medica

location_facility: Ankara University Medical Faculty; Medikal Onkoloji

location_facility: Hospital Universitario Miguel Servet; Servicio Oncologia

location_facility: Helsinki University Central Hospital; Dept of Oncology

location_facility: Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica

location_facility: A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica

location_facility: Universitätsklinikum Jena, Klinik für Innere Medizin II; Hämatologie und Internistische Onkologie

location_facility: Multidisciplinary medical center; Chemotherapy department

location_facility: RED-Oncology GmbH; Dres.Gerdt Hübner/Clemens Engels (Oldenburg)/Yael Bonnin-Gruber (Eutin)

location_facility: Hospital Universitari i Politecnic La Fe; Oncologia

location_facility: Severance Hospital, Yonsei University Health System; Oncology

location_facility: Instituto do Cancer do Estado de Sao Paulo - ICESP

location_facility: Institutul Regional de Oncologie Iasi; Clinica de Hematologie

location_facility: Hospital Universitario Virgen Macarena; Servicio de Oncologia

location_facility: St Vincent'S Uni Hospital; Medical Oncology

location_facility: Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne

location_facility: Universitätsklinikum Münster, Medizinische Klinik A, Translationale Onkologie

location_facility: Akdeniz University Medical Faculty; Medical Oncology Department

location_facility: Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii

location_facility: Complejo Hospitalario de Navarra; Servicio de Oncologia

location_facility: Institut Paoli-Calmettes; Oncologie Medicale 1

location_facility: Fundacion Clinica Valle del Lili; Unidad de Investigaciones Clinicas

location_facility: Universitätsklinikum Augsburg; II. Med. Klinik

location_facility: Uzsoki Utcai Korhaz; Onkoradiológiai Osztály

location_facility: IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima

location_facility: James Lind Centro de Investigación Del Cáncer

location_facility: Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

location_facility: University College London Hospitals NHS Foundation Trust - University College Hospital

location_facility: Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology

location_facility: Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia

location_facility: Oslo universitetssykehus HF, Ullevål, Kreftsenteret

location_facility: Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala

location_facility: U. O. Oncologia Medica, Ospedale Santa Chiara

location_facility: Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.

location_facility: Hospital Universitario 12 de Octubre; Servicio de Oncologia

location_facility: Universitätsklinikum Heidelberg;Innere Medizin V, Hämatologie/Onkologie

location_facility: Istanbul University Cerrahpaşa-Cerrahpaşa Medical Faculty; Medikal Onkoloji Departmani

location_facility: Riga East Clinical University Hospital Latvian Oncology Centre

location_facility: Rabin MC; Davidof Center - Oncology Institute

location_facility: Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika

location_facility: Univ General Hosp Heraklion; Medical Oncology

location_facility: Uni Hospital of Ioannina; Oncology Dept.

location_facility: Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine

location_facility: Inst. Nacional de Cancerologia; Clinica de Seno

location_facility: SLK-Kliniken Heilbronn GmbH; Klinik für Innere Medizin III; Schwerpunkt Häma./Onko./Palliativm.

location_facility: Hammersmith Hospital; Garry Weston Centre

location_facility: Centre Eugene Marquis; Service d'oncologie

location_facility: Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie

location_facility: Universitätsklinikum Frankfurt, UCT; Universitäres Centrum für Tumorerkrankungen

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck

location_facility: Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden

location_facility: Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Chemotherapie & Infektionskrankhei

location_facility: Waterford Regional Hospital; Department Of Medical Oncology

location_facility: Chaim Sheba medical center, Oncology division

location_facility: Bradford Hill Centro de Investigaciones Clinicas; Bradford Hill Centro de Investigaciones Clinicas

location_facility: Hospital Clinico San Carlos; Servicio de Oncologia

location_facility: Uni. der Johannes Gutenberg-Universitaet Mainz; III. Medizinische Klinik und Poliklinik

location_facility: Policlinico Univ. - A.O. Mater Domini; U.O. Di Oncoematologia

location_facility: Universitätsklinikum Düsseldorf; Klinik für Hämatologie, Onkologie und Klinische Immunologie

location_facility: Debreceni Egyetem Klinikai Kozpont ; Department of Oncology

location_facility: Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer

location_facility: Hacettepe Uni Medical Faculty Hospital; Oncology Dept

location_facility: Western General Hospital; Edinburgh Cancer Center

location_facility: Instituto Nacional de Cancer - INCa; Oncologia

location_facility: Onkologisches Zentrum - Onkologie Dachau

location_facility: Hospital Quiron de Madrid; Servicio de Oncologia

location_facility: Hospital Nacional Cayetano Heredia; Hematology - Oncology

location_facility: Ramathibodi Hospital; Medicine/Oncology; Clinical Research Center

location_facility: Hospital Sant Joan Despi- Moises Broggi; Servicio de Oncologia

location_facility: Charité-Universitätsm. Berlin; Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunolo.

location_facility: Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Oddzial Badan Wczesnych Faz

location_facility: Klinikum Mannheim III. Medizinische Klinik

location_facility: CRLCC-Francois Baclesse; Oncologie Médicale

location_facility: Aarhus Universitetshospital; Afdeling for Eksperimentel Klinisk Onkologi

location_facility: Instituto Nacional de Enfermedades Neoplasicas

location_facility: Multiprofile Hospital for Active Treatment Uni Hospital; Department of medicinal oncology

location_facility: Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly

location_facility: Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie

location_facility: Theagenio Anticancer Hospital; 3Rd Oncology Clinic

location_facility: Bacs-Kiskun Megyei Korhaz, SZTE AOK Oktato Korhaza, Onkoradiologiai Kozpont

location_facility: Hospital Clínic i Provincial; Servicio de Oncología

location_facility: LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie

location_facility: Arcispedale Santa Maria Nuova; Oncologia

summary: This study will compare the efficacy and safety of molecularly-guided therapy versus standard platinum-containing chemotherapy in participants with poor-prognosis cancer of unknown primary site (CUP; non-specific subset) who have achieved disease control after 3 cycles of first-line platinum based induction chemotherapy.


title: Induction Study #2 - A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease

lead_sponsor: Celgene

ReferenceCitation: Feagan BG, Schreiber S, Afzali A, Rieder F, Hyams J, Kollengode K, Pearlman J, Son V, Marta C, Wolf DC, D'Haens GG. Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program. Contemp Clin Trials. 2022 Oct 5;122:106958. doi: 10.1016/j.cct.2022.106958. [Epub ahead of print]

location_country:
Serbia
Spain
Lithuania
Ukraine
United States
South Africa
Poland
Hong Kong
Portugal
Slovenia
Austria
Australia
Russian Federation
Israel
Turkey
Sweden
Slovakia
Canada
Hungary
China
Germany
Bulgaria
Taiwan
Greece
Georgia
Finland
Korea, Republic of
France
Colombia
Netherlands

location_facility: Hospital Universitario de Coimbra- Hospitais de Universidade de Coimbra

location_facility: Multiprofile Hospital for Active Treatment Tokuda Hospital Sofia

location_facility: Advance Clinical Research - Dayton Internal Medicine

location_facility: Beijing YouYi Hospital-Beijing Friendship Hospital Capital Medical University

location_facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

location_facility: General Hospital of Thessaloniki Hippokration

location_facility: Euromed Multi-Specialty Center for Contemporary Medicine LLC

location_facility: Centro Hospitalar do Alto Minho - Unidade Local de Saúde do Alto Minho, EPE

location_facility: JSC Evex Medical Corporation - Telavi Referral Hospital

location_facility: Universitaetsklinikum Charite - Ruppiner Kliniken GmbH

location_facility: University of Massachusetts Memorial Medical Center

location_facility: Military Medical Academy, Clinic of Gastroenterology and Hepatology

location_facility: University Hospital Marques de Valdecilla (HUMV)

location_facility: John Hunter Hospital and Hunter Medical Research Institute

location_facility: University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna ISUL EAD

location_facility: Csongrad County Dr. Bugyi Istvan Hospital

location_facility: General Hospital Djordje Jovanovic Zrenjanin

location_facility: West Edmonton Gastroenterology Consultants

location_facility: Diagnostic and Consulting Center Alexandrovska

location_facility: Polish Mother's Memorial Hospital - Research Institute

location_facility: Allergy, Asthma and Immunology Center, PC

location_facility: Vilnius University Hospital Santariskiu Klinikos

location_facility: University of Pennsylvania Cancer Center

location_facility: Kindred Medical Institute for Clinical Trials, LLC

location_facility: Vrije Universiteit Medisch Centrum (VUMC)

location_facility: Chang Gung Medical Foundation, Kaohsiung Memorial Hospital

location_facility: Institute of Gastroenterology and Hepatology at Ha'Emek Medical Center

location_facility: Multidisciplinary Clinic of the St. Nicholas, LLC

location_facility: Non-Public Healthcare Facility Allmedica Clinical Trials

location_facility: Istanbul Medeniyet Uni Goztepe Training&Res Hosp

location_facility: Henry Ford Medical Center - New Center One

location_facility: Mid America Gastrointestinal Consultants

location_facility: Vilnius University Hospital Santariskes Clinics

location_facility: Dnipropetrovsk II Mechnykov Regional Clinical Hospital Surgery Department 2

location_facility: BIK-KYIV Ukrainian German Gastroenterology Center

location_facility: Helsicore - Israeli Georgian Medical Research Clinic

location_facility: G.G. Kuvatov Republican Clinical Hospital

location_facility: Clinical Research Center Early-Phase Research Facility

location_facility: Univerzitna nemocnica Bratislava, Nemocnica Ruzinov

location_facility: Assistance Publique - Hopitaux de Paris - Hopital Beaujon

location_facility: DiGiovanna Institute for Medical Education And Research

location_facility: Harvard Medical School - Boston Children's Hospital

location_facility: Jan Mikulicz Radecki University Hospital

location_facility: Odesa Regional Clinical Hospital Regional Gastroenterology Center Surgery Department

location_facility: St. John Paul 2nd Municipal Hospital in Elblag

location_facility: The Seventh Medical Center of PLA General Hospital

location_facility: UC Davis Health - Gastroenterology and Hepatology Clinical Trials Unit

location_facility: S.V. Beliaev Kemerovo Regional Clinical Hospital

location_facility: Cotton ONeil Clinical Research Center Digestive Health

location_facility: Clinical Hospital Center - Dr. Dragisa Misovic-Dedinje

location_facility: JSC Infectious Disease, AIDS and Clinical Immunology Research Center

location_facility: University Of California At San Francisco

location_facility: Vinnytsia M.I. Pyrohov Regional Clinical Hospital

location_facility: Gastroenterological Special Practice at Wittenbergplatz

location_facility: Hospital Universitario de Gran Canaria Dr. Negrin

location_facility: Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

location_facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics

location_facility: The First Affiliated Hospital of Nanchang University

location_facility: Petz Aladar Megyei Oktato Korhaz,II. Belgyogyaszat

location_facility: Clinical Hospital Center Zvezdara Clinic of Internal Diseases

location_facility: World of the Health Inc. General Hospital Rimavska Sobota

location_facility: Zhangzhou Municipal Hospital of Fujian Province

location_facility: Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

location_facility: Emory University Health Science Research Building

location_facility: Health Centre Metabolic Diseases Outpatient Clinic in Wierzchoslawice

location_facility: Ohio State University Wexner Medical Center

location_facility: Joint Venture Company Diagnostic Center, Bioterm Ltd.

location_facility: Centro Hospitalar do Alto Ave, Hospital da Senhora da Oliveira Guimaraes

location_facility: Clinical Center of Vojvodina, Clinic of Gastroenterology and Hepatology

location_facility: Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin

location_facility: City Clinical Hospital No 31 - St. Petersburg

location_facility: A.N. Ryzhikh State Research Center for Coloproctology

location_facility: Istanbul University Cerrahpasa Medical Faculty

location_facility: University Hospital Puerta de Hierro Majadajonda

location_facility: Medical Scientific Manufacturing Association Dvizheniye Clinic

location_facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

location_facility: Medical Center Medical Clinic Blagomed LLC

location_facility: N.N. Burdenko Penza Regional Clinical Hospital

location_facility: TWOJA PRZYCHODNIA Medical Centre of Szczecin LLC

location_facility: Saint-Etienne University Hospital Center

location_facility: Southern California Research Institute Medical Group, Inc.

location_facility: Sotiria Chest Diseases Hospital of Athens

location_facility: Cancer Care Associates of OK-N PorterAvenue

location_facility: I.I. Mechnikov North-Western State Medical University

location_facility: University of California at San Francisco

location_facility: Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz

location_facility: Semmelweis Egyetem - Altalanos Orvostudomanyi Kar

location_facility: JSC Evex Medical Corporation - Oncology Center

location_facility: Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University

location_facility: City Clinical Hospital n.a. V.M. Buyanov

location_facility: Endoterapia PFG LLC, Endotherapy PFG Outpatient Clinic Branch No 1

location_facility: Paramount Medical Research & Consulting, LLC

location_facility: Western Michigan University Homer Stryker M.D. School of Medicine

location_facility: Helsinki University Central Hospital (HUCH)

location_facility: Sultan Abdulhamid Han Egitim ve Arastirma Hastanesi

location_facility: Atlanta Center For Gastroenterology, P.C.

location_facility: Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

location_facility: The Second Affiliated Hospital Of Zhengzhou University

location_facility: University Clinical Hospital of Valencia

location_facility: JSC Evex Medical Corporation - Batumi Referral Hospital

location_facility: Clinical Hospital Center Bezanijska Kosa, Clinic of Internal Medicine

location_facility: LTD Academician N.Kipshidze Central University Clinic

location_facility: Connecticut Clinical Research Foundation

location_facility: Ural State Medical Academy - Medical Association Novaya Bolnitsa

location_facility: Johann Wolfgang Goethe University Hospital

location_facility: CHU Nantes University Hospital - Hotel Dieu Hospital

location_facility: Ivano-Frankivsk Regional Clinical Hospital

location_facility: Scientific Research Institute of Physiology and Basic Medicine

location_facility: University Hospital of Girona Dr. Josep Trueta

location_facility: State Unitary Enterprise Passengeravtotrans

location_facility: Velocity Clinical Research/ Gut Whisperer

summary: This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.


title: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial Comparing CB-839 in Combination With Cabozantinib (CB-Cabo) vs. Placebo With Cabozantinib (Pbo-Cabo) in Patients With Advanced or Metastatic Renal Cell Carcinoma (RCC)

acronym: CANTATA

summary: This clinical trial is a randomized Phase 2 evaluation of CB-839 (telaglenastat) in combination with cabozantinib versus placebo with cabozantinib in patients with advanced or metastatic Renal Cell Carcinoma with a clear cell component.

status: Completed

study_completion_date_type: Actual

ReferenceCitation: Tannir NM, Agarwal N, Porta C, Lawrence NJ, Motzer R, McGregor B, Lee RJ, Jain RK, Davis N, Appleman LJ, Goodman O Jr, Stadler WM, Gandhi S, Geynisman DM, Iacovelli R, Mellado B, Sepúlveda Sánchez JM, Figlin R, Powles T, Akella L, Orford K, Escudier B. Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial. JAMA Oncol. 2022 Oct 1;8(10):1411-1418. doi: 10.1001/jamaoncol.2022.3511.

lead_sponsor: Calithera Biosciences, Inc

location_country:
Spain
Italy
United Kingdom
Australia
New Zealand
United States
France
Germany

location_facility: The Center for Cancer and Blood Disorders

location_facility: Fundación Instituto Valencia d'Oncología (IVO)

location_facility: University of Miami Sylvester Comprehensive Cancer Center

location_facility: Institut Paoli-Calmettes Service d'Urologie

location_facility: Hôpital Européen Georges-Pompidou (HEGP)

location_facility: AMITA Health Cancer Institute & Outpatient Center

location_facility: University of Utah, Huntsman Cancer Institute

location_facility: Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute

location_facility: St. Bartholomew's Hospital, Barts Health NHS Trust

location_facility: University of Modena and Reggio Emilia (Azienda Ospedaliera-Universitaria Policlinico Modena)

location_facility: Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: Northwestern Medicine Cancer Center Warrenville

location_facility: St. Luke's Mountain States Tumor Institute

location_facility: Sarah Cannon Research Institute UK Limited

location_facility: Hospital Universitari VHIO - Vall d'Hebron Departamento de Oncologia

location_facility: HealthPartners Institute, Regions Cancer Care Center

location_facility: Southern Highlands Private Hospital (Cancer Centre)

location_facility: U.O.C. ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo

location_facility: Centre hospitalier régional universitaire (CHRU) de Besançon - Jean-Minjoz

location_facility: Centre hospitalier universitaire (CHU) Henri-Mondor

location_facility: Presidio Ospedaliero Antonio Perrino - U.O.C. Oncologia Medica

location_facility: Universitätsklinikum Tübingen, Klinik für Urologie

location_facility: Medical University Heidelberg, NCT (National Center for Tumour Diseases), Medical Oncology

location_facility: Penrose Cancer Center, Research Department

location_facility: Georgia Cancer Center at Augusta University

location_facility: Nottingham University Hospitals NHS Trust - City Hospital Campus

location_facility: University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center

location_facility: Institut Gustave Roussy - Le département de Medecine oncologique

location_facility: Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Klinik und Poliklinik

location_facility: Technischen Universitat München - Urologische Klinik

location_facility: Unità Operativa (UO) di Oncologia Medica - ICS Maugeri

location_facility: Istituto Europeo di Oncologia - Divisione di Oncologia Medica Urogenitale e Cervico Facciale

location_facility: H.Lee Moffitt Cancer & Research Institute (Moffitt Cancer Center)

location_facility: U.O. Oncologia Ospedale degli Infermi - Dipartimento di Oncologia ed Ematologia

location_facility: University of Mississippi Medical Center

location_facility: Institut Català d'Oncologia (ICO) L'Hospitalet

location_facility: CHU de Strasbourg (Les Hôpitaux Universitaires de Strasbourg)

location_facility: North Shore Hematology Oncology Associates PC dba NY Cancer and Blood Specialists

location_facility: Universitätsklinikum Essen (AöR) Westdeutsches Tumorzentrum

location_facility: Froedtert Hospital and the Medical College of Wisconsin

location_facility: Azienda Ospedaliero Universitaria San Luigi Gonzaga

location_facility: Centro Integral Oncologico Clara Campal (CIOCC) HM

location_facility: Hospital Universitario Virgen de Macarena

location_facility: Institut de Cancérologie de l'Ouest (ICO) - Centre René Gauducheau

location_facility: El Hospital Clínic i Provincial de Barcelona (HCPB)

location_facility: IUCTO Bureau des Essais Cliniques (Institut Claudius Regaud)

location_facility: Mater Misericordiae Limited - Division of Cancer Services

location_facility: Fondazione IRCCS Istituto Nazionale dei Tumori

location_facility: INTEGRIS Cancer Institute of Oklahoma Proton Campus

location_facility: University of Maryland, Greenebaum Comprehensive Cancer Center

location_facility: Charité Universitätsmedizin Berlin, Dept. of Interdisciplinary Urology

location_facility: Institut de Cancérologie de Montpellier (ICM)

location_facility: Policlinico Universitario Campus Bio-Medico

location_facility: Salinas Valley Memorial Healthcare System

location_facility: S.C. Oncologia - ASST Cremona P.O. Ospedale di Cremona

status_simplified: Completed


title: Prospective Non Interventional Study of Cabozantinib Tablets in Adults With Advanced Renal Cell Carcinoma Following Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Therapy

acronym: CASSIOPE

summary: The objective of this study is to understand the utilization of cabozantinib in subjects with advanced renal cell carcinoma (RCC) following prior VEGF-targeted therapy in real life settings in terms of dose modifications due to adverse events (AEs) when used as a second line therapy or third and later line therapy. Other patterns of use of cabozantinib will also be described.

study_type: Observational

time_perspective: Prospective

lead_sponsor: Ipsen

location_country:
Poland
Spain
Greece
Austria
Italy
Netherlands
United Kingdom
France
Belgium
Germany
Czechia

location_facility: Universitatsklinikum fur Urologie und Andrologie

location_facility: East Kent Hospitals University NHS Foundation Trust

location_facility: Institut de Cancérologie Lucien Neuwirth (ICLN)

location_facility: UOC Oncologia Azienda Ospedaliera Sant-Andrea

location_facility: Frimley Health NHS Foundation Trust - Wezham Park and Heatherwood Hospitals

location_facility: National Cancer Institute "Fondazione G. Pascale" IRCCS

location_facility: Fondazione IRCCS Istituto Nazionale Dei Tumori

location_facility: Hospital Clinico Lozano Blesa de Zaragoza

location_facility: Azienda Ospedaliera Universitaria Integrata Verona

location_facility: Hospital Universitario Central de Asturias (Huca)

location_facility: Centre de Lutte Contre le Cancer (CLCC) - Institut Jean Godinot

location_facility: Rosemere Cancer Centre, Royal Preston Hospital

location_facility: Azienda Ospedaliero-Universitaria di Parma

location_facility: Azienda Ospedaliera S.Orsola Malpighi di Bologna

location_facility: Fakultni Nemocnice na Bulovce, Institut of Radiation Oncology

location_facility: Universitaetsklinikum Frankfurt - Department of Urology

location_facility: Wojskowy Instytut Medyczny, Klinika Onkologii

location_facility: Dept of Urology, Eberhard-Karls-University Tuebingen

location_facility: Szpital Kliniczny Przemienienia Panskiego w Poznaniu

location_facility: University Medical Center Hamburg-Eppendorf

location_facility: Complejo Hospitalario Universitario de Compostela

location_facility: Thomayerova Nemocnice, Onkologická Klinika 1. LF UK A TN

location_facility: Dep. Medical Oncology, University Hospital of Ioannina

location_facility: Fondazione Salvatore Maugeri - I.R.C.C.S

location_facility: University Medical Center LMU Munich - Campus Grosshadern, Urologische Klinik und Poliklinik Marchionnish R. 15

location_facility: Freeman Hospital-Northern Centre For Cancer Care

location_facility: Mount Vernon Cancer Centre - East and North Hertfordshire NHS Trust

location_facility: Krajská Nemocnice Liberec, A.S., Komplexní Onkologické Centrum

location_facility: Fakultni Nemocnice Kralovske Vinohrady (FNKV) - Radioterapeuticka a Onkologicka klinika

location_facility: Azienda Ospedaliero Universitaria di Modena


title: Phase 3 Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Reltecimod as Compared to Placebo in Addition to Standard of Care in Patients With Sepsis-associated Acute Kidney Injury (SA-AKI)

summary: Phase 3 multicenter study to be conducted in up to 90 qualified participating sites globally to assess the efficacy and safety of Reltecimod vs placebo in patients with sepsis-associated Stage 2/3 AKI.

status: Terminated

lead_sponsor: Atox Bio Ltd

location_country:
United States
France

location_facility: Erie County Medical Center-Affliate of SUNYat Buffalo

location_facility: The Pennsylvania State University and The Milton S. Hershey Medical Center

location_facility: University of Texas Health Science Center at San Antonio

location_facility: University of Cincinnati Medical Center (UCMC)

location_facility: University of Arkansas for Medical Sciences

location_facility: University of California, Davis Medical Center

location_facility: University of Minnesota Medical Center-Fairview

status_simplified: Unknown


title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

lead_sponsor: Pfizer

ReferenceCitation: Agarwal N, Azad A, Shore ND, Carles J, Fay AP, Dunshee C, Karsh LI, Paccagnella ML, Santo ND, Elmeliegy M, Lin X, Czibere A, Fizazi K. Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: TALAPRO-2 phase III study design. Future Oncol. 2022 Feb;18(4):425-436. doi: 10.2217/fon-2021-0811. Epub 2022 Jan 26.

ipd_sharing_description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

location_country:
Spain
Italy
United Kingdom
United States
Peru
Belgium
Japan
South Africa
Czechia
Poland
Portugal
Australia
Argentina
Israel
Norway
Sweden
Brazil
Canada
Hungary
China
Germany
New Zealand
Finland
Korea, Republic of
France
Chile

location_facility: Sociedad de Investigaciones Medicas Ltda (SIM)

location_facility: First Affiliated Hospital of Xiamen University

location_facility: Desert Hematology Oncology Medical Group, Incorporation

location_facility: Fundacao Pio XII - Hospital de Cancer de Barretos

location_facility: Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - Napoli

location_facility: Centre integre universitaire de sante et de services sociaux de l'Estrie

location_facility: Hospital Clinico Universitario de Santiago de Compostela

location_facility: The Clatterbridge Cancer Centre - Liverpool

location_facility: Alaska Urological Institute dba Alaska Clinical Research Center

location_facility: The Second Hospital of Tianjin Medical University

location_facility: University of Utah, Huntsman Cancer Institute

location_facility: Oslo University Hospital -Ullevål & Radiumhospitalet

location_facility: The University of Kansas Clinical Research Center

location_facility: Cancercare Langenhoven Drive Oncology Centre

location_facility: National Hospital Organization Shikoku Cancer Center

location_facility: Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii i Radioterapii

location_facility: Hamamatsu University School of Medicine, University Hospital

location_facility: AMITA Health Adventist Medical Center Hinsdale

location_facility: The First Affiliated Hospital of Xi'an Jiaotong University

location_facility: Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intezet

location_facility: AdventHealth Medical Group Hematology & Oncology at Kissimmee

location_facility: Clinical Trial Pharmacy, The Catholic University of Korea

location_facility: Instituto Português Oncologia de Coimbra Francisco Gentil - E.P.E

location_facility: The First People's Hospital of Lianyungang

location_facility: Clinical Trial Pharmacy, National Cancer Center

location_facility: The First Affiliated Hospital of Fujian Medical University

location_facility: Lakeland Regional Health Hollis Cancer Center

location_facility: UPMC Hillman Cancer Center - Monroeville

location_facility: GU Research Network/Urology Cancer Center

location_facility: Instituto do Cancer do Estado de Sao Paulo - ICESP

location_facility: UPMC Hillman Cancer Center - Upper St. Clair

location_facility: UPMC Hillman Cancer Center - Arnold Palmer - Mt View

location_facility: Associated Medical Professionals of New York, PLLC

location_facility: Centro Gaucho Integrado - Hospital Mae de Deus

location_facility: St. Olavs Hospital, Trondheim University Hospital

location_facility: Hospital Militar Central "Coronel Luis Arias Schreiber"

location_facility: Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Oncologia (CEPHO)

location_facility: John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy

location_facility: University of Colorado Hospital- Anschutz Outpatient Pavilion

location_facility: Providence Cancer Institute Franz Clinic

location_facility: Sharp Memorial Hospital Investigational Pharmacy

location_facility: Providence Oncology and Hematology Care Clinic - Westside

location_facility: Hospital Privado Centro Medico de Cordoba

location_facility: Hospital Nossa Senhora da Conceicao - Grupo Hospitalar Conceicao

location_facility: Providence Cancer Institute Newberg Clinic

location_facility: CHUM - Centre Hospitalier de l'Universite de Montreal

location_facility: Cancer Center Clinical Trial, Asan Medical Center

location_facility: New Jersey Cancer Care and Blood Disorders

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

location_facility: Institut Catala d'Oncologia - ICO L'Hospitalet

location_facility: Hospital General Universitario Gregorio Maranon

location_facility: Premier Medical Group of the Hudson Valley PC

location_facility: National Hospital Organization Kure Medical Center and Chugoku Cancer Center

location_facility: UPMC Hillman Cancer Center - Passavant (OHA)

location_facility: NZOZ Szpital Mazovia; Oddzial urologiczny

location_facility: The Clatterbridge Cancer Centre NHS Foundation Trust

location_facility: TriState urologic Services PSC Inc., dba The Urology Group

location_facility: Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean

location_facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

location_facility: Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers

location_facility: Peking University First Hospital / Urology Department

location_facility: Kyungpook National University Chilgok Hospital

location_facility: Centro Clínico Académico - Braga, Associação (2CABraga)

location_facility: The Catholic University of Korea, Seoul St. Mary's Hospital

location_facility: Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina

location_facility: UPMC Hillman Cancer Center - Passavant (HOA)

location_facility: Inova Schar Cancer Institute Infusion Pharmacy

location_facility: Hopitaux Universitaires de Strasbourg - ICANS

location_facility: Azienda Ospedaliero-Universitaria Policlinico Sant' Orsola Malpighi

location_facility: Montefiore Medical Center - Montefiore Medical Park

location_facility: University of Wisconsin Clinical Science Center

location_facility: Sociedad Prosalud Montes y Orlandi Ltda. Fantasy name (Orlandi Oncologia)

location_facility: The First Affiliated Hospital of Wenzhou Medical University

location_facility: Severance Hospital, Yonsei University Health System

location_facility: Hirosaki University School of Medicine & Hospital

location_facility: Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Clinical Trial Site

location_facility: South Jordan Health Center -University of Utah

location_facility: Instituto Português de Oncologia do Porto Francisco Gentil

location_facility: Sociedade Beneficencia e Caridade de Lajeado - Hospital Bruno Born

location_facility: Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School

location_facility: University of Colorado Hospital- Anschutz Inpatient Pavilion

location_facility: Przychodnia Lekarska "Komed" Roman Karaszewski

location_facility: Tom Baker Cancer Centre - Alberta Health Services

location_facility: Centro Hospitalar do Porto - Hospital de Santo Antonio

location_facility: Centro de Investigaciones Clinicas Vina del Mar

location_facility: National Hospital Organization Kyushu Cancer Center

location_facility: Imperial College Healthcare NHS Trust, Charing Cross Hospital

location_facility: Clinique Victor Hugo-Centre Jean Bernard

location_facility: University of California, Irvine Medical Center

location_facility: Instituto do Cancer do Estado de Sao Paulo-ICESP-Nucleo de Pesquisa

location_facility: West China Hospital of Sichuan University

location_facility: The First Affiliated Hospital of Nanchang University

location_facility: National Hospital Organization Tokyo Medical Center

location_facility: Corporacio Sanitaria i Universitaria Parc Tauli

location_facility: Union Hospital, Tongji Medical College of Huazhong University of Science & Technology

location_facility: AdventHealth Medical Group Hematology & Oncology at Celebration

location_facility: Centro de Investigacion Pergamino SA - Clinica Pergamino SA

location_facility: Hospital Universitario Pedro Ernesto-Centro de Pesquisas (CEPUSA)

location_facility: Redwood Health Center-University of Utah

location_facility: Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

location_facility: National Hospital Organization Hokkaido Cancer Center

location_facility: University of Wisconsin Hospital & Clinics

location_facility: Second Affiliated Hospital of Suzhou University

location_facility: The Fifth People's Hospital of Shanghai, Fudan University

location_facility: Centro de Pesquisa Clinica em Oncologia - Hospital Sao Lucas da Pontificia Universidade Catolica

location_facility: Vanderbuilt University Medical Center, Department of Urology

location_facility: Integrated Clinical Oncology Network Pty Ltd (ICON)

location_facility: Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" Cemic

location_facility: Farmington Health Center -University of Utah

location_facility: Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA

location_facility: Fudan University Cancer Hospital, Deptartment of Urology

location_facility: Baylor Scott & White Medical Center - Temple

location_facility: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

location_facility: Investigational Drug Services, Advent Health Orlando

location_facility: Hospital Universitario Virgen de la Arrixaca

location_facility: National Hospital Organization Kumamoto Medical Center

location_facility: Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. Markiewicza

location_facility: University of Colorado Hospital - Anschutz Cancer Pavilion

location_facility: Loma Linda University Cancer Center - Hematology/Oncology Clinic

location_facility: The First affiliated Hospital of Anhui Medical University

location_facility: Providence Cancer Institute Clackamas Clinic

summary: This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.


title: A Phase 3, Randomized, Double-blind Study of Adjuvant Nivolumab Versus Placebo for Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

acronym: CheckMate 9DX

summary: This study will investigate if nivolumab will improve recurrence-free survival (RFS) compared to placebo in participants with HCC who have undergone complete resection or have achieved a complete response after local ablation, and who are at high risk of recurrence

location_country:
Spain
Italy
United Kingdom
United States
Romania
Belgium
Japan
Hong Kong
Austria
Australia
Russian Federation
Argentina
Puerto Rico
Mexico
Singapore
Brazil
Canada
Germany
Taiwan
New Zealand
Korea, Republic of
France
Chile
Colombia
Netherlands

location_facility: Arkhangelsk Clinical Oncological Dispensary

location_facility: Sylvester Comprehensive Cancer Center/ UMHC

location_facility: Wellcome Trust Imperial Clinical Research Facility (CRF) (Sir John McMichael Centre (SJMC))

location_facility: Fondazione Policlinico Gemelli - Universita Cattolica del Sacro Cuore

location_facility: Azienda Ospedaliera Specialistica dei Colli Monaldi-Cotugno-CTO

location_facility: Laura and Issac Perlmutter Cancer Center at NYU Langone - Belleview Hospital


title: An Open-label, Multi-Center, Phase IIIb Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Patients 18 Years of Age or Older With Newly-diagnosed FLT3-mutated Acute Myeloid Leukemia Who Are Eligible for "7+3" or "5+2" Chemotherapy

lead_sponsor: Novartis Pharmaceuticals

location_country: Croatia Serbia Spain Italy Estonia Finland Lithuania Hungary France Romania Norway Sweden Bulgaria Slovakia Czechia

summary: The purpose of this study is to gather and evaluate additional safety and efficacy data on the combination of midostaurin and standard of care for adult patients with newly diagnosed Fms-like tyrosine kinase receptor (FLT3) mutated Acute Myeloid Leukemia (AML) who are eligible for standard induction and consolidation


title: A Randomized, Open-label, Multi-center Phase III Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

acronym: HIMALAYA

summary: This is a randomized, open-label, multi-center, global, Phase III study to assess the efficacy and safety of durvalumab plus tremelimumab combination therapy and durvalumab monotherapy versus sorafenib in the treatment of patients with no prior systemic therapy for unresectable HCC. The patients cannot be eligible for locoregional therapy

lead_sponsor: AstraZeneca

location_country:
Taiwan
Brazil
Hong Kong
Spain
Italy
Russian Federation
Canada
Thailand
Vietnam
Ukraine
Korea, Republic of
United States
France
China
India
Japan
Germany