type: U.S. NIH Grant/Contract

title: A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer

summary: This randomized phase III clinical trial studies how well tamoxifen citrate, anastrozole, letrozole, or exemestane with or without chemotherapy work in treating patients with breast cancer that has spread from where it began in the breast to surrounding normal tissue (invasive). Estrogen can cause the growth of breast cancer cells. Hormone therapy, using tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor cells. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, may fight breast cancer by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving tamoxifen citrate, anastrozole, letrozole, or exemestane is more effective with combination chemotherapy in treating patients with breast cancer.

ReferenceCitation: Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN. 21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer. N Engl J Med. 2021 Dec 16;385(25):2336-2347. doi: 10.1056/NEJMoa2108873. Epub 2021 Dec 1.

lead_sponsor: National Cancer Institute (NCI)

location_country:
Saudi Arabia
Ireland
Spain
Mexico
Canada
Korea, Republic of
United States
France
Puerto Rico
Colombia

location_facility: Sutter Cancer Centers Radiation Oncology Services-Cameron Park

location_facility: Kaiser Permanente Moanalua Medical Center

location_facility: Associates In Hematology Oncology PC-Upland

location_facility: Mercyhealth Hospital and Cancer Center - Janesville

location_facility: Alliance for Childhood Diseases/Cure 4 the Kids Foundation

location_facility: Trillium Health Partners - Queensway Health Centre

location_facility: Franciscan Saint Francis Health-Beech Grove

location_facility: University of Tennessee Health Science Center

location_facility: Our Lady of the Lake Physicians Group - Medical Oncology

location_facility: Great Plains Health Callahan Cancer Center

location_facility: Cleveland Clinic Cancer Center Strongsville

location_facility: UPMC-Johnstown/John P. Murtha Regional Cancer Center

location_facility: Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

location_facility: SwedishAmerican Regional Cancer Center/ACT

location_facility: Marshfield Medical Center-EC Cancer Center

location_facility: Clinique Victor Hugo-Centre Jean Bernard

location_facility: McLaren Cancer Institute-Northern Michigan

location_facility: Saint James Community Hospital and Cancer Treatment Center

location_facility: Tulane University Health Sciences Center

location_facility: Institut Curie-Centre Rene Huguenin Saint Cloud

location_facility: Forrest General Hospital / Cancer Center

location_facility: Saint Joseph Radiation Oncology Resource Center

location_facility: Fairview Clinics and Surgery Center Maple Grove

location_facility: Radiation Oncology Centers of Nevada Southeast

location_facility: Kaiser Permanente - Largo Medical Center

location_facility: Southeastern Medical Oncology Center-Goldsboro

location_facility: Wellmont Holston Valley Hospital and Medical Center

location_facility: AtlantiCare Regional Medical Center -Main Campus

location_facility: Memorial Regional Cancer Center Day Road

location_facility: Prisma Health Cancer Institute - Eastside

location_facility: Cleveland Clinic Cancer Center Beachwood

location_facility: Northeast Alabama Regional Medical Center

location_facility: ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

location_facility: Southeastern Medical Oncology Center-Jacksonville

location_facility: Michiana Hematology Oncology PC-Mishawaka

location_facility: NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

location_facility: Hawaii Cancer Care Inc - Waterfront Plaza

location_facility: Valley Medical Oncology Consultants-Fremont

location_facility: Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

location_facility: Wellmont Medical Associates Oncology and Hematology-Bristol

location_facility: Providence Cancer Institute Clackamas Clinic

location_facility: Northeast Georgia Medical Center-Gainesville

location_facility: Scotland Memorial Hospital-Laurinburg Cancer Center

location_facility: HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

location_facility: Saint Louis Cancer and Breast Institute-South City

location_facility: Virginia Mason Bainbridge Island Medical Center

location_facility: The James Graham Brown Cancer Center at University of Louisville

location_facility: Franciscan Research Center-Northwest Medical Plaza

location_facility: William E Kahlert Regional Cancer Center/Sinai Hospital

location_facility: Kaiser Permanente Medical Center-Vacaville

location_facility: Michiana Hematology Oncology PC-Westville

location_facility: Palo Alto Medical Foundation-Gynecologic Oncology

location_facility: Rocky Mountain Cancer Centers-Greenwood Village

location_facility: Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

location_facility: Tacoma/Valley Radiation Oncology Centers-Jackson Hall

location_facility: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio

location_facility: Atlantic Health Sciences Corporation-Saint John Regional Hospital

location_facility: Novant Health Cancer Institute - Mooresville

location_facility: Geisinger Medical Center-Cancer Center Hazleton

location_facility: Saint Luke's Cancer Institute - Meridian

location_facility: Sutter Solano Medical Center/Cancer Center

location_facility: East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill

location_facility: Harrison HealthPartners Hematology and Oncology-Poulsbo

location_facility: University of Maryland Shore Medical Center at Easton

location_facility: Harbin Clinic Medical Oncology and Clinical Research

location_facility: Texas Tech University Health Sciences Center-El Paso

location_facility: South Georgia Medical Center/Pearlman Cancer Center

location_facility: Karmanos Cancer Institute at McLaren Greater Lansing

location_facility: Medical Oncology Hematology Consultants PA

location_facility: East Bay Medical Oncology Hematology Associates Inc

location_facility: Saint Alphonsus Cancer Care Center-Caldwell

location_facility: Northwell Health/Center for Advanced Medicine

location_facility: Halifax Health Medical Center-Centers for Oncology

location_facility: Mayo Clinic Health System-Franciscan Healthcare

location_facility: CHU de Quebec-Hopital du Saint-Sacrement (HSS)

location_facility: Illinois CancerCare-Community Cancer Center

location_facility: Michigan Cancer Research Consortium NCORP

location_facility: Southeast Clinical Oncology Research Consortium NCORP

location_facility: University of Cincinnati Cancer Center-West Chester

location_facility: Mount Sinai Comprehensive Cancer Center at Aventura

location_facility: Palo Alto Medical Foundation-Camino Division

location_facility: Palo Alto Medical Foundation Health Care

location_facility: Novant Health New Hanover Regional Medical Center

location_facility: Wellmont Medical Associates Oncology and Hematology-Johnson City

location_facility: University of Mississippi Medical Center

location_facility: UH Seidman Cancer Center at Saint John Medical Center

location_facility: Minnesota Oncology Hematology PA-Woodbury

location_facility: Siteman Cancer Center at Christian Hospital

location_facility: Saint Joseph's Hospital/Children's Hospital-Tampa

location_facility: Tacoma/Valley Radiation Oncology Centers-Puyallup

location_facility: Toledo Community Hospital Oncology Program CCOP

location_facility: Saint Luke's Cancer Institute - Fruitland

location_facility: Providence Saint Joseph Medical Center/Disney Family Cancer Center

location_facility: Kapiolani Medical Center for Women and Children

location_facility: Texas Tech University Health Sciences Center-Lubbock

location_facility: HaysMed University of Kansas Health System

location_facility: University of Chicago Comprehensive Cancer Center

location_facility: Tacoma/Valley Radiation Oncology Centers-Gig Harbor

location_facility: Lowcountry Hematology Oncology PA-West Ashley

location_facility: Providence Regional Cancer System-Centralia

location_facility: Southern Illinois University School of Medicine

location_facility: University of Kansas Cancer Center - Lee's Summit

location_facility: Baylor All Saints Medical Center at Fort Worth

location_facility: Legacy Good Samaritan Hospital and Medical Center

location_facility: Hospital Clinico Universitario de Valencia

location_facility: Smilow Cancer Hospital Care Center-Fairfield

location_facility: University Medical Center of Southern Nevada

location_facility: Trillium Health Partners - Credit Valley Hospital

location_facility: The University of Kansas Cancer Center-South

location_facility: Lincoln Medical and Mental Health Center

location_facility: Fort Wayne Medical Oncology and Hematology Inc-Parkview

location_facility: CHUM - Centre Hospitalier de l'Universite de Montreal

location_facility: Aurora Health Care Germantown Health Center

location_facility: Sanford USD Medical Center - Sioux Falls

location_facility: HealthCare Partners Medical Group Oncology/Hematology-San Martin

location_facility: Hospital Clinico Universitario Lozano Blesa

location_facility: Montefiore Medical Center - Moses Campus

location_facility: Ohio State University Comprehensive Cancer Center

location_facility: Kaiser Permanente-Deer Valley Medical Center

location_facility: UPMC-Heritage Valley Health System Beaver

location_facility: West Virginia University Charleston Division

location_facility: Penn State Health Saint Joseph Medical Center

location_facility: Green Bay Oncology at Saint Vincent Hospital

location_facility: Regional West Medical Center Cancer Center

location_facility: Wichita NCI Community Oncology Research Program

location_facility: Saint Vincent Hospital Cancer Center at Oconto Falls

location_facility: Tacoma/Valley Radiation Oncology Centers-Saint Joe's

location_facility: King Faisal Specialist Hospital and Research Centre

location_facility: Smilow Cancer Hospital Care Center - Waterford

location_facility: Legacy Emanuel Hospital and Health Center

location_facility: Prisma Health Greenville Memorial Hospital

location_facility: Coborn Cancer Center at Saint Cloud Hospital

location_facility: Walter Reed National Military Medical Center

location_facility: Wayne State University/Karmanos Cancer Institute

location_facility: Kaiser Permanente Medical Center - Santa Clara

location_facility: TidalHealth Nanticoke / Allen Cancer Center

location_facility: Avera McKennan Hospital and University Health Center

location_facility: Groupe Hospitalier Public du Sud de l'Oise Senlis

location_facility: MidHudson Regional Hospital of Westchester Medical Center

location_facility: Metro Minnesota Community Oncology Research Consortium

location_facility: Providence Regional Cancer System-Shelton

location_facility: The Research Institute of the McGill University Health Centre (MUHC)

location_facility: University of Kansas Health System Saint Francis Campus

location_facility: Comprehensive Cancer Centers of Nevada-Summerlin

location_facility: Atrium Health University City/LCI-University

location_facility: Seattle Cancer Care Alliance at EvergreenHealth

location_facility: North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

location_facility: University of Texas Health Science Center at San Antonio

location_facility: Providence Saint Mary Regional Cancer Center

location_facility: Baptist Health Madisonville/Merle Mahr Cancer Center

location_facility: Cancer Research Consortium of West Michigan NCORP

location_facility: Sainte Genevieve County Memorial Hospital

location_facility: Cancer Care Specialists of Illinois - Decatur

location_facility: Dana-Farber/Brigham and Women's Cancer Center at Milford Regional

location_facility: University of Washington Medical Center - Montlake

location_facility: Novant Health Cancer Institute - Huntersville

location_facility: Hospital Universitari de Girona Doctor Josep Trueta

location_facility: Saint Joseph Regional Medical Center-Mishawaka

location_facility: University of Wisconsin Carbone Cancer Center

location_facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone

location_facility: Smilow Cancer Hospital Care Center-Trumbull

location_facility: Dana Farber Community Cancer Care-Quincy

location_facility: Peninsula Cancer Institute-Cancer Specialists of Tidewater

location_facility: University of Pittsburgh Cancer Institute (UPCI)

location_facility: Toledo Clinic Cancer Centers-Bowling Green

location_facility: Freeport Memorial Hospital/Leonard C Ferguson Cancer Center

location_facility: UPMC Cancer Centers - Arnold Palmer Pavilion

location_facility: Ascension Southeast Wisconsin Hospital - Saint Joseph Campus

location_facility: Ascension Providence Hospitals - Southfield

location_facility: NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

location_facility: Michiana Hematology Oncology PC-Crown Point

location_facility: Oklahoma Cancer Specialists and Research Institute-Tulsa

location_facility: Northern Indiana Cancer Research Consortium

location_facility: University of Alabama at Birmingham Cancer Center

location_facility: UH Seidman Cancer Center at Landerbrook Health Center

location_facility: UH Seidman Cancer Center at Southwest General Hospital

location_facility: Cancer Center-Metro Medical Center Bayamon

location_facility: Centra Lynchburg Hematology-Oncology Clinic Inc

location_facility: East Bay Medical Oncology Hematology Medical Associates-Antioch

location_facility: Prisma Health Cancer Institute - Spartanburg

location_facility: Novant Health Cancer Institute - Matthews

location_facility: Smilow Cancer Hospital-Derby Care Center

location_facility: Comprehensive Cancer Centers of Nevada - Henderson

location_facility: MultiCare Deaconess Cancer and Blood Specialty Center - Valley

location_facility: Genesis Healthcare System Cancer Care Center

location_facility: University of Florida Health Science Center - Gainesville

location_facility: Kootenai Clinic Cancer Services - Post Falls

location_facility: Hattiesburg Clinic - Hematology/Oncology Clinic

location_facility: Radiation Oncology Centers of Nevada Central

location_facility: Sutter Cancer Centers Radiation Oncology Services-Roseville

location_facility: Instituto Nacional De Cancerologia de Mexico

location_facility: Carolina Blood and Cancer Care Associates PA

location_facility: Hematology and Oncology Associates of North East Pennsylvania

location_facility: Sutter Cancer Centers Radiation Oncology Services-Auburn

location_facility: Hematology Oncology Associates of Fredericksburg Inc

location_facility: Emory University Hospital/Winship Cancer Institute

location_facility: University of Oklahoma Health Sciences Center

location_facility: Owensboro Health Mitchell Memorial Cancer Center

location_facility: Hematology and Oncology Associates-Oakland

location_facility: Saint Vincent Hospital Cancer Center at Sturgeon Bay

location_facility: MultiCare Deaconess Cancer and Blood Specialty Center - North

location_facility: Departemental Hospitalier Roche-sur-Yon (Les Oudairies)

location_facility: Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

location_facility: ThedaCare Regional Medical Center - Appleton

location_facility: Vanderbilt Breast Center at One Hundred Oaks

location_facility: Northwest NCI Community Oncology Research Program

location_facility: Saint Mary's Oncology/Hematology Associates of Marlette

location_facility: Saint Vincent Hospital Cancer Center Green Bay

location_facility: Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

location_facility: Saint Patrick Hospital - Community Hospital

location_facility: Washington University School of Medicine

location_facility: John H Stroger Jr Hospital of Cook County

location_facility: Henry Ford Macomb Hospital-Clinton Township

location_facility: Kaiser Permanente-Gaithersburg Medical Center

location_facility: HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

location_facility: State University of New York Upstate Medical University

location_facility: Constantinou, Costas L MD (UIA Investigator)

location_facility: Vanderbilt-Ingram Cancer Center Cool Springs

location_facility: Novant Health Carolina Surgical - Randolph

location_facility: University of Michigan Comprehensive Cancer Center

location_facility: Central Vermont Medical Center/National Life Cancer Treatment

location_facility: Dayton NCI Community Oncology Research Program

location_facility: Saint Vincent Hospital Cancer Center at Saint Mary's

location_facility: Johns Hopkins University/Sidney Kimmel Cancer Center

location_facility: Faith Regional Health Services Carson Cancer Center

location_facility: Doctors Medical Center- JC Robinson Regional Cancer Center

location_facility: Prisma Health Cancer Institute - Butternut

location_facility: Hopital Prive Drome Ardeche-Clinique Pasteur

location_facility: Great Lakes Cancer Management Specialists-Rochester Hills

location_facility: Seoul National University Bundang Hospital

location_facility: Cotton O'Neil Cancer Center / Stormont Vail Health

location_facility: Geisinger Wyoming Valley/Henry Cancer Center

location_facility: Sidney Kimmel Cancer Center Washington Township

location_facility: Cleveland Clinic Cancer Center Independence

location_facility: Great Lakes Cancer Management Specialists-Macomb Medical Campus

location_facility: University of California Davis Comprehensive Cancer Center

location_facility: Robert Wood Johnson University Hospital Somerset

location_facility: Comprehensive Cancer Centers of Nevada - Central Valley

location_facility: Providence Willamette Falls Medical Center

location_facility: Virginia Commonwealth University/Massey Cancer Center

location_facility: Franciscan Saint Anthony Health-Michigan City

location_facility: Cleveland Clinic Wooster Family Health and Surgery Center

location_facility: Saint Alphonsus Cancer Care Center-Boise

location_facility: Memorial Health University Medical Center

location_facility: Delaware Health Center-Grady Cancer Center

location_facility: Cancer Centers of Southwest Oklahoma Research

location_facility: Hematology Oncology Associates of Illinois - Skokie

location_facility: The Cancer Institute of New Jersey Hamilton

location_facility: Virginia Mason Federal Way Medical Center

location_facility: Skagit Regional Health Cancer Care Center

location_facility: Hospital Clinico Universitario Virgen de la Victoria

location_facility: Smilow Cancer Hospital Care Center - Guiford

location_facility: Comprehensive Cancer Centers of Nevada-Southeast Henderson

location_facility: Benefis Healthcare- Sletten Cancer Institute

location_facility: Gaston Hematology and Oncology Associates-Belmont

location_facility: Natalie Warren Bryant Cancer Center at Saint Francis

location_facility: Grupo Espanol de Investigacion en Cancer de Mama

location_facility: HealthCare Partners Medical Group Oncology/Hematology-Tenaya

location_facility: Penn State Milton S Hershey Medical Center

location_facility: CHI Saint Vincent Cancer Center Hot Springs

location_facility: American Fork Hospital / Huntsman Intermountain Cancer Center

location_facility: Smilow Cancer Hospital-Orange Care Center

location_facility: Vanderbilt University/Ingram Cancer Center

location_facility: PEI Cancer Treatment Centre-Queen Elizabeth Hospital

location_facility: Thunder Bay Regional Health Science Centre

location_facility: Yale-New Haven Hospital Saint Raphael Campus

location_facility: Prisma Health Cancer Institute - Laurens

location_facility: University Hospitals Parma Medical Center

location_facility: The Dana-Farber Cancer Institute at Londonderry

location_facility: Florida Hospital Memorial Medical Center

location_facility: UMass Memorial Medical Center - University Campus

location_facility: USC / Norris Comprehensive Cancer Center

location_facility: Mercy Clinic-Rolla-Cancer and Hematology

location_facility: Oncology Hematology Associates of Saginaw Valley PC

location_facility: Carolinas Medical Center/Levine Cancer Institute

location_facility: Centre d'Oncologie et de Radiotherapie Pays Basque

location_facility: Academic Hematology Oncology Specialists

location_facility: Dana-Farber/Brigham and Women's Cancer Center at South Shore

location_facility: Hematology Oncology Associates of Illinois-Highland Park

location_facility: UH Seidman Cancer Center at Lake Health Mentor Campus

location_facility: Marion L Shepard Cancer Center at Vidant Beaufort Hospital

location_facility: McLaren Cancer Institute-Central Michigan

location_facility: Cleveland Clinic Cancer Center/Fairview Hospital

location_facility: Oncology Associates at Mercy Medical Center

location_facility: Montefiore Medical Center-Weiler Hospital

location_facility: Ascension Columbia Saint Mary's Hospital - Milwaukee

location_facility: Great Lakes Cancer Management Specialists-Doctors Park

location_facility: Saint Mary's Oncology/Hematology Associates of West Branch

location_facility: Cheshire Medical Center-Dartmouth-Hitchcock Keene

location_facility: UPMC Jefferson Regional Radiation Oncology

location_facility: California Pacific Medical Center-Pacific Campus

location_facility: Michigan Breast Specialists-Macomb Township

location_facility: Saint Luke's University Hospital-Bethlehem Campus

location_facility: Columbus NCI Community Oncology Research Program

location_facility: McGill University Department of Oncology

location_facility: Ottawa Regional Hospital and Healthcare Center

location_facility: Cancer Center of Kansas-Wichita Medical Arts Tower

location_facility: University of Cincinnati Cancer Center-UC Medical Center

location_facility: Greenville Health System Cancer Institute-Andrews

location_facility: Missouri Baptist Outpatient Center-Sunset Hills

location_facility: UPMC Uniontown Hospital Radiation Oncology

location_facility: Gaston Hematology and Oncology Associates

location_facility: Siteman Cancer Center at West County Hospital

location_facility: Institut de Cancerologie de l'Ouest-Rene Gauducheau

location_facility: Minnesota Oncology Hematology PA-Maplewood

location_facility: Louisiana State University Health Science Center

location_facility: Hospital Universitari Germans Trias i Pujol

location_facility: Comprehensive Cancer Centers of Nevada - Northwest

location_facility: PeaceHealth United General Medical Center

location_facility: Rocky Mountain Regional VA Medical Center

location_facility: Christiana Care Health System-Christiana Hospital

location_facility: Mary Bird Perkins Cancer Center - Covington

location_facility: Trinity Health IHA Medical Group Hematology Oncology - Canton

location_facility: Mid-Illinois Hematology Oncology Associates Limited

location_facility: Medical Oncology and Hematology Associates-West Des Moines

location_facility: BCCA-Cancer Centre for the Southern Interior

location_facility: Olive View-University of California Los Angeles Medical Center

location_facility: Marshfield Clinic Cancer Center at Sacred Heart

location_facility: Louisiana Hematology Oncology Associates LLC

location_facility: Southeast Nebraska Cancer Center - 68th Street Place

location_facility: Kaiser Permanente - Kensington Medical Center

location_facility: Atrium Medical Center-Middletown Regional Hospital

location_facility: Lovelace Medical Center-Saint Joseph Square

location_facility: Yale-New Haven Hospital North Haven Medical Center

location_facility: Huntsman Cancer Institute/University of Utah

location_facility: Grand River Regional Cancer Centre at Grand River Hospital

location_facility: Alta Bates Summit Medical Center - Summit Campus

location_facility: Hinsdale Hematology Oncology Associates Incorporated

location_facility: Lowcountry Hematology Oncology PA-Mount Pleasant

location_facility: City of Hope Comprehensive Cancer Center

location_facility: Alegent Health Bergan Mercy Medical Center

location_facility: Institut de Cancerologie de l'Ouest- Angers

location_facility: Ochsner LSU Health Monroe Medical Center

location_facility: Centre Hospitlier Intercommunal de Creteil

location_facility: Eastern Connecticut Hematology and Oncology Associates

location_facility: Long Beach Memorial Medical Center-Todd Cancer Institute

location_facility: Western Illinois Cancer Treatment Center

location_facility: Cone Health Cancer Center at Alamance Regional

location_facility: Siteman Cancer Center at Saint Peters Hospital

location_facility: University of Vermont and State Agricultural College

location_facility: Kansas Institute of Medicine Cancer and Blood Center

location_facility: Smilow Cancer Hospital-Waterbury Care Center

location_facility: Wilcox Memorial Hospital and Kauai Medical Clinic

location_facility: OSF Saint Francis Radiation Oncology at Peoria Cancer Center

location_facility: Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

location_facility: UC Irvine Health/Chao Family Comprehensive Cancer Center

location_facility: Providence Regional Cancer System-Aberdeen

location_facility: Saint Alphonsus Medical Center-Baker City

location_facility: Michiana Hematology Oncology PC-South Bend

location_facility: AtlantiCare Health Park-Cape May Court House

location_facility: University of Kentucky/Markey Cancer Center

location_facility: Juravinski Cancer Centre at Hamilton Health Sciences

location_facility: Clinical Saint-Pierre/Centre Catalan d?Oncologie

location_facility: Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

location_facility: Marshfield Medical Center-River Region at Stevens Point

location_facility: University Hospitals Sharon Health Center

location_facility: UC Comprehensive Cancer Center at Silver Cross

location_facility: Kaiser Permanente-Capitol Hill Medical Center

location_facility: Berkshire Medical Center - Cancer Center

location_facility: Southeastern Medical Oncology Center-Clinton

location_facility: Presbyterian - Saint Lukes Medical Center - Health One

location_facility: Marshfield Clinic - Wisconsin Rapids Center

location_facility: Anchorage Associates in Radiation Medicine

location_facility: Trinity Health IHA Medical Group Hematology Oncology - Brighton

location_facility: UPMC Washington Hospital Radiation Oncology

location_facility: The Don and Sybil Harrington Cancer Center

location_facility: Dell Seton Medical Center at The University of Texas

location_facility: Saint Mary's Hospital and Regional Medical Center

location_facility: Smilow Cancer Hospital Care Center at Saint Francis

location_facility: Complejo Hospitalario Universitario de Albacete

location_facility: AMITA Health Cancer Institute and Outpatient Center

location_facility: Great Lakes Cancer Management Specialists-Macomb Professional Building

location_facility: Carolina Blood and Cancer Care Associates PA-Lancaster

location_facility: Valley Medical Oncology Consultants-Castro Valley

location_facility: SSM Health Saint Louis University Hospital

location_facility: Harrison HealthPartners Hematology and Oncology-Bremerton

location_facility: University of South Alabama Mitchell Cancer Institute

location_facility: Columbus Oncology and Hematology Associates Inc

location_facility: OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

location_facility: Kaiser Permanente Los Angeles Medical Center

location_facility: Saint Luke's Cancer Institute - Twin Falls

location_facility: Kansas City NCI Community Oncology Research Program

location_facility: University of Kansas Cancer Center - North

location_facility: Indiana University/Melvin and Bren Simon Cancer Center

location_facility: Ascension Columbia Saint Mary's Hospital Ozaukee

location_facility: University of Kansas Cancer Center-Overland Park

location_facility: IU Health Central Indiana Cancer Centers-East

location_facility: Trinity Health Saint Mary Mercy Livonia Hospital

location_facility: Suburban Community Hospital and Cancer Center

location_facility: Smilow Cancer Hospital-Torrington Care Center

location_facility: Kaiser Permanente Tysons Corner Medical Center

location_facility: University of Miami Miller School of Medicine-Sylvester Cancer Center

location_facility: Pulmonary Medicine Center of Chattanooga-Hixson

location_facility: Lowcountry Hematology Oncology PA-North Charleston

location_facility: Maine Center for Cancer Medicine-Scarborough

location_facility: Northwestern Medicine Cancer Center Kishwaukee

location_facility: Genesys Regional Medical Center-West Flint Campus

location_facility: Delaware Clinical and Laboratory Physicians PA

location_facility: Sutter Cancer Centers Radiation Oncology Services-Vacaville

location_facility: LSU Health Sciences Center at Shreveport

location_facility: Mercy Clinic Oncology and Hematology-Ardmore

location_facility: McFarland Clinic PC-Trinity Cancer Center

location_facility: Guthrie Medical Group PC-Robert Packer Hospital

location_facility: MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

location_facility: University Health Network-Princess Margaret Hospital

location_facility: Genesee Cancer and Blood Disease Treatment Center

location_facility: Cleveland Clinic Cancer Center Mansfield

location_facility: Green Bay Oncology Limited at Saint Mary's Hospital

location_facility: George Washington University Medical Center

location_facility: UT Southwestern/Simmons Cancer Center-Dallas

location_facility: Novant Health Presbyterian Medical Center

location_facility: Kaiser Permanente-Woodlawn Medical Center

location_facility: Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

location_facility: Mountain Blue Cancer Care Center - Swedish

location_facility: Alta Bates Summit Medical Center-Herrick Campus

location_facility: Michiana Hematology Oncology PC-Plymouth

location_facility: Steward Saint Elizabeth's Medical Center

location_facility: Garneau, Stewart C MD (UIA Investigator)

location_facility: Medical Oncology and Hematology Associates-Des Moines

location_facility: UPMC-Coraopolis/Heritage Valley Radiation Oncology

location_facility: Central Illinois Hematology Oncology Center

location_facility: Christus Saint Vincent Regional Cancer Center

location_facility: Cleveland Hematology and Oncology Associates PC

location_facility: Heartland Hematology and Oncology Associates Incorporated

location_facility: Saint Rose Ambulatory and Surgery Center

location_facility: Christiana Care Health System-Wilmington Hospital

location_facility: Arnot Ogden Medical Center/Falck Cancer Center

location_facility: Comprehensive Cancer Centers of Nevada-Horizon Ridge

location_facility: Ascension Saint Francis - Reiman Cancer Center

location_facility: Michigan Breast Specialists-Grosse Pointe Woods

location_facility: Cooper Hospital University Medical Center


title: A Randomized, Double-blind Study of the Efficacy of Intravenous Bonviva in the Relief of Pain After Recent Vertebral Osteoporotic Fracture in Osteoporotic Patients.

summary: This 2 arm study will assess the efficacy and safety of intravenous Bonviva in patients with osteoporosis experiencing pain after recent vertebral osteoporotic fracture. Patients will be randomized to receive either Bonviva (3mg i.v. bolus injection) or placebo. The anticipated time on study treatment is <3 months, and the target sample size is 100-500 individuals.

status: Completed

study_completion_date_type: Actual

study_type: Interventional

design_allocation: Randomized

primary_purpose: Treatment

enrollment_type: Actual

lead_sponsor: Hoffmann-La Roche

intervention_type: Drug

lead_sponsor_type: industriel

status_simplified: Completed


type: EudraCT Number

title: A Randomized, 2-Arm, Phase 3 Study of Elranatamab (PF-06863135) Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease-Positive After Undergoing Autologous Stem-Cell Transplantation

summary:
The purpose of this study is to evaluate whether elranatamab monotherapy can provide clinical benefit compared to lenalidomide monotherapy (control) in participants with newly diagnosed multiple myeloma who are MRD-positive after undergoing autologous stem cell transplant.

Participants in the study will either receive elrantamab as an injection under the skin at the study clinic or lenalidomide orally once daily at home. Participants who will receive elranatamab will start receiving one dose every week after the initial step-up doses. After 6 months of treatment, the frequency of clinic visits for injections will decrease to every other week. Participation in the study will be approximately five years.

study_start_date_type: Actual

status: Recruiting

study_completion_date_type: Anticipated

enrollment_type: Anticipated

ipd_sharing: Yes

ipd_sharing_description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

lead_sponsor: Pfizer

location_country:
Spain
Italy
Belgium
Japan
Czechia
Poland
Australia
India
Israel
Turkey
Norway
Sweden
Canada
Hungary
Germany
Taiwan
Greece
Finland
Korea, Republic of
France
Netherlands

location_facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi

location_facility: Institut Catala d' Oncologia. Hospital Germans Trias i Pujol

location_facility: Chonnam National University Hwasun Hospital

location_facility: Theageneio Cancer Hospital of Thessaloniki

location_facility: Chang Gung Medical Foundation-Linkou Branch

location_facility: Hospital Universitario Quironsalud Madrid

location_facility: Fondazione Policlinico Universitario Agostino Gemelli

location_facility: Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)

location_facility: Rajiv Gandhi Cancer Institute And Research Centre

location_facility: Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku

location_facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital(Seoul St. Mary's Hospital)

location_facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

location_facility: Institut Catala Oncologia - Hospital Universitari de Girona Dr Josep Trueta

location_facility: Universita di Siena -Azienda Ospedaliera Universitaria Senese-Policlincio Santa Maria Alle Scotte

location_facility: Complejo Hospitalario Universitario de Santiago

location_facility: Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

location_facility: Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital Kliniczny

location_facility: Azienda Ospedaliero Universitaria Senese

location_facility: Erciyes Universitesi Tıp Fakultesi Hastaneleri

location_facility: University Hospital,Kyoto Prefectural University of Medicine

location_facility: Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE

location_facility: Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórhá

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

location_facility: National Hospital Organization Okayama Medical Center

location_facility: Hospital General Universitario Gregorio Marañon

location_facility: Centre Hospitalier Universitaire de Poitiers

location_facility: Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi

location_facility: Seoul National University Bundang Hospital

location_facility: Institut Català d'Oncologia - L'Hospitalet

location_facility: Hospital Universitari i Politecnic La Fe

location_facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site God

location_facility: Centre Integre Universitaire de la Santé et de Services Sociaux de l'Est-de-l'ile-de-Montreal,

location_facility: Aydın Adnan Menderes Universitesi Hastanesi

location_facility: National Hospital Organization Kumamoto Medical Center

location_facility: Ankara Universitesi Tip Fakultesi Hastanesi

status_simplified: Ongoing


title: A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Efficacy of ARCR Augmented With REGENETEN™ Bioinductive Implant System in Full-thickness Tears (Large or Massive) Repair Versus ARCR Alone

acronym: REGENETEN

summary: The study is designed to assess the safety and efficacy of Arthroscopic rotator cuff repair (ARCR) augmented with REGENETEN in subjects requiring full-thickness rotator cuff tear repair or revision repair versus Arthroscopic rotator cuff repair alone.

ipd_sharing: No

lead_sponsor: Smith & Nephew, Inc.

location_country:
Hong Kong
United Kingdom
Australia
Canada
Switzerland
United States
France
Singapore

location_facility: Royal National Orthopaedic Hospital NHS Trust

location_facility: University Hospital of South Manchester NHS Foundation Trust

location_facility: The Royal Orthopaedic Hospital NHS Foundation Trust

location_facility: University Hospitals Coventry and Warwickshire

location_facility: Liverpool University Hospitals NHS Foundation Trust

intervention_type: Procedure


title: Interruption of the Calcineurine Inhibitors (ICN) and Introduction of Mycophenolate Mofetil (MMF) in Liver Transplant Patients With Side Effects Due to ICN: Study of the Reduction of the Risks of Rejection by Mycophenolate Mofetil Therapeutic Drug Monitoring

acronym: MONOCEPT

summary:
The aim of this project is to determine whether, in liver transplant patients with side effects due to ICN, the use of MMF in monotherapy can be optimised by dose adjustment based on the area under the curve (AUC) of mycophenolic acid (MPA). It involves a multicentre phase IV trial with direct individual benefit.

A population of 130 liver transplant patients at 2 to 10 years post-transplant, showing significant clinical ICN side effects and being given bitherapy by ICN +MMF will be included and randomised 1:1 in two arms:

Arm 1: progressive interruption of ICN after obtaining an AUC of MPA of 50 mg.h/l, followed by MMF monotherapy with dose adjustment based on the AUC of MPA,
Arm 2: continuation of the ICN+MMF bitherapy without MMF therapeutic drug monitoring.

The main judgement criterion will be the incidence of acute rejection in the 2 groups at 6 months. The secondary judgment criterion will be the evaluation of the benefit of stopping ICN on the side effects caused by these drugs.

lead_sponsor: University Hospital, Limoges

location_facility:
CHU de Caen
CHU de Montpellier
Hôpital Edouard Herriot
CHU de Nice
Hôpital Saint Antoine
Hôpital Paul Brousse
CHU de Grenoble
Hôpital Cochin
CHU de Marseille
Hôpital Beaujon
CHU de Strasbourg
CHU de Toulouse
CHU de Bordeaux
CHU de Lille
Hôpital Henri Mondor
CHU de Besançon
CHU de Rennes

lead_sponsor_type: academique


title: PLATINUM: A Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Element™) for the Treatment of up to Two De Novo Coronary Artery Lesions

acronym: PLATINUM

summary:
The purpose of this study is to evaluate the safety and effectiveness of the PROMUS Element™ Everolimus-Eluting Coronary Stent System for the treatment of patients with up to 2 de novo atherosclerotic coronary artery lesions.

This clinical trial compares outcomes in patients treated with PROMUS Element to those in patients treated with a different everolimus-eluting coronary stent. The lesions are of average length in average-sized vessels ("workhorse"). A companion sub-trial evaluates outcomes in smaller vessels (SV) and another sub-trial evaluates outcomes in longer lesions (LL).

ReferenceType: result

ReferenceCitation: Stone GW, Teirstein PS, Meredith IT, Farah B, Dubois CL, Feldman RL, Dens J, Hagiwara N, Allocco DJ, Dawkins KD; PLATINUM Trial Investigators. A prospective, randomized evaluation of a novel everolimus-eluting coronary stent: the PLATINUM (a Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System [PROMUS Element] for the Treatment of Up to Two de Novo Coronary Artery Lesions) trial. J Am Coll Cardiol. 2011 Apr 19;57(16):1700-8. doi: 10.1016/j.jacc.2011.02.016. Epub 2011 Apr 4.

ReferenceType: derived

ReferenceCitation: Kelly CR, Teirstein PS, Meredith IT, Farah B, Dubois CL, Feldman RL, Dens J, Hagiwara N, Rabinowitz A, Carrié D, Pompili V, Bouchard A, Saito S, Allocco DJ, Dawkins KD, Stone GW. Long-Term Safety and Efficacy of Platinum Chromium Everolimus-Eluting Stents in Coronary Artery Disease: 5-Year Results From the PLATINUM Trial. JACC Cardiovasc Interv. 2017 Dec 11;10(23):2392-2400. doi: 10.1016/j.jcin.2017.06.070.

ipd_sharing: Undecided

ipd_sharing_description: The data and study protocol for this clinical trial may be made available to other researchers in accordance with the Boston Scientific Data Sharing Policy (http://www.bostonscientific.com/en-US/data-sharing-requests.html).

lead_sponsor: Boston Scientific Corporation

location_country:
Denmark
Poland
Portugal
United Kingdom
Latvia
Austria
Australia
Netherlands
Finland
New Zealand
United States
France
Malaysia
Singapore
Belgium
Japan
Germany

location_facility: Washington University School of Medicine

location_facility: Jewish Hospital and St. Mary's Healthcare

location_facility: Ohio Health Research and Innovation Institute

location_facility: Medical Center of the Rockies (Loveland)

location_facility: Institut Cardiovasculaire - Paris Sud / Institut Hospitalier Jacques Cartier

location_facility: Wake Forest University School of Medicine

location_facility: St. Luke's Hospital / Mid America Heart Institute

location_facility: Cooper Hospital/University Medical Center

location_facility: Saiseikai Yokohama-City Eastern Hospital

location_facility: Tokyo Women's Medical University Hospital

location_facility: Guys and St. Thomas NHS Foundation Trust St. Thomas Hospital

location_facility: Banner Good Samaritan Regional Medical Center

location_facility: MediQuest Research Group Inc. at Munroe Regional Medical Center

location_facility: Sakakibara Heart Institute, Japan Research Promotion Society for Cardiovascular Diseases

location_facility: Providence Health & Services - Washington

location_facility: Lindner Center for Research and Education at The Christ Hospital

location_facility: Herz-Kreislauf-Zentrum Segeberger Kliniken GmbH

location_facility: Japan Community Health Care Organization Hokkaido Hospital

location_facility: Southern Illinois University Memorial Medical Center

location_facility: Penn State Milton S Hershey Medical Center

location_facility: Aspirus Heart and Vascular Institute - Research and Education

location_facility: St. Mary's Duluth Clinic Regional Heart Center

location_facility: University of California Davis Medical Center

location_facility: Moses H. Cone Memorial Hospital/LeBauer Cardiovascular Research Foundation

intervention_type: Device


title: An Open Label Study to Evaluate the Effect of Avastin in Association With Chemotherapy on Progression-free Survival in Patients With Progressive Advanced/Metastatic Well-differentiated Digestive Endocrine Tumors of the Gastrointestinal Tract

summary: This 2 arm study will assess the efficacy and safety of two systemic treatments including Avastin in patients with previously-untreated progressive locally advanced/metastatic well-differentiated digestive endocrine tumors. Patients with duodeno-pancreatic tumors (arm 1) will be treated with 5FU/streptozotocin iv (5FU 400mg/m2/d D1 to D5;streptozotocin 500mg/m2/d/iv D1 to D5;D1=D42) every 6 weeks, plus Avastin 7.5mg/kg iv every 3 weeks. Patients with gastrointestinal tract tumors (arm 2) will be treated with Xeloda 1000mg/m2 po bid D1 to D14 plus Avastin 7.5mg/kg iv D1=D21 every 3 weeks. The patients will be treated with chemotherapy for a minimum of 6 months, unless there is tumor progression and/or unacceptable toxicity. The anticipated time on study treatment is until disease progression or unacceptable toxicity, and the target sample size is <100 individuals.

design_allocation: Non-Randomized


primary_purpose: Prevention

intervention_type: Biological

acronym: REVAXIS® versus DT Polio® as a second booster in 6 year-old children

title: Comparison of the Immunogenicity and Safety of a Combined Adsorbed Low Dose Diphtheria, Tetanus and Inactivated Poliomyelitis Vaccine (REVAXIS®) With a Combined Diphtheria, Tetanus and Inactivated Poliomyelitis Vaccine (DT Polio®) When Given as a Booster Dose at 6 Years of Age

lead_sponsor: Sanofi Pasteur, a Sanofi Company

source: euctr

ReferenceCitation: Gajdos V, Soubeyrand B, Vidor E, Richard P, Boyer J, Sadorge C, Fiquet A. Immunogenicity and safety of combined adsorbed low-dose diphtheria, tetanus and inactivated poliovirus vaccine (REVAXIS (®)) versus combined diphtheria, tetanus and inactivated poliovirus vaccine (DT Polio (®)) given as a booster dose at 6 years of age. Hum Vaccin. 2011 May;7(5):549-56. Epub 2011 May 1.

summary:
Primary objective:

To demonstrate the non inferiority between REVAXIS® and DT Polio® when given as a second booster to healthy 6 year-old children .

Secondary objectives:

Additional immunogenicity assessments.
To describe the safety profile of a single dose of REVAXIS® or DT-Polio®


title: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prophylaxis of Migraine in Participants With Episodic Migraine Who Have Previously Failed 2 to 4 Classes of Oral Prophylactic Treatments (ELEVATE)

acronym: ELEVATE

summary: This study will assess the safety, tolerability, and efficacy of Atogepant 60 mg compared with placebo in episodic migraines in participants who previously failed 2 to 4 classes of oral prophylactic treatments.

ipd_sharing_description: AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

lead_sponsor: Allergan

location_country:
Denmark
Poland
Spain
Italy
Russian Federation
Australia
Netherlands
Canada
United Kingdom
Sweden
Hungary
United States
France
Germany
Czechia

location_facility: AP-HP - Hopital Lariboisière /ID# 226221

location_facility: Azienda Ospedaliero Universitaria Careggi /ID# 226502

location_facility: Hospital Clinico Universitario Lozano Blesa /ID# 226395

location_facility: Hospital Universitario Vall d'Hebron /ID# 226230

location_facility: Re:Cognition Health - London /ID# 226540

location_facility: AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 226503

location_facility: Klinische Forschung Hannover-Mitte GmbH /ID# 226195

location_facility: Universitaetsmedizin Rostock /ID# 226517

location_facility: Velocity Clinical Research - Boise /ID# 226320

location_facility: Pharmacology Research Institute (PRI) - Encino (Wake) /ID# 226434

location_facility: Pharmacology Research Institute (PRI) - Los Alamitos (Wake) /ID# 226405

location_facility: University Clinical Hospital of Valladolid /ID# 226528

location_facility: Univ. of Bologna-IRCCS-Istituto delle Scienze Neurologiche /ID# 226475

location_facility: Leeds Teaching Hospitals NHS Trust /ID# 226538

location_facility: Hospital Santa Creu i Sant Pau /ID# 226550

location_facility: Ospedale Ss. Filippo e Nicola /ID# 226530

location_facility: The Royal Melbourne Hospital /ID# 226402

location_facility: Aggarwal and Associates Limited /ID# 226321

location_facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 226397

location_facility: Diex Recherche Sherbrooke Inc. /ID# 226375

location_facility: Klinische Forschung Dresden GmbH /ID# 226194

location_facility: Hospital Clinico Universitario de Valencia /ID# 226472

location_facility: Department of Neurology, University of Szeged /ID# 226442

location_facility: Alpine Clinical Research Center /ID# 226201

location_facility: Centrum Leczenia Padaczki i Migreny /ID# 226543

location_facility: Karolinska university hospital, Huddinge /ID# 226215

location_facility: Universitaetsklinikum Tuebingen /ID# 226529

location_facility: Pharmacology Research Institute (PRI) - Los Alamitos (Wake) /ID# 226388

location_facility: Gabinet Lekarski Jacek Rozniecki /ID# 226323

location_facility: Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 226485

location_facility: Amici Clinical Research - Raritan /ID# 226282

location_facility: Vitos Orthopaedische Klinik Kassel gemeinnuetzige GmbH /ID# 231767

location_facility: Universitaetsklinikum Jena Klinik fuer Neurologie /ID# 226439

location_facility: King's College Hospital NHS Foundation Trust /ID# 226525

location_facility: CTI Clinical Trial and Consulting /ID# 226281

location_facility: Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej /ID# 226235

location_facility: Allied Physicians - Fort Wayne Neurological Center /ID# 226350

location_facility: CHU Nice - Hopital de Cimiez /ID# 226401

location_facility: FutureSearch Trials of Dallas, LP /ID# 226493

location_facility: Bashkir State Medical University /ID# 226552

location_facility: Ottawa Headache Centre Research Inc /ID# 226257

location_facility: Pharmakologisches Studienzentrum Chemnitz GmbH /ID# 226202

location_facility: Queen Elizabeth University Hospital /ID# 226492

location_facility: Hospital Clinico Universitario San Carlos /ID# 226483

location_facility: St Pancras Clinical Research /ID# 226551

location_facility: Deaconess Clinic - Gateway Health Center /ID# 226481

location_facility: Centrum Medyczne Pratia Gdynia /ID# 226437

location_facility: Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 226361

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 226441

location_facility: Albuquerque Clinical Trials, Inc /ID# 233445

location_facility: Northwest Clinical Research Center /ID# 226228

location_facility: ZorgSaam Zorggroep Zeeuws-Vlaanderen /ID# 226317

location_facility: Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 226399

location_facility: Canisius-Wilhelmina Ziekenhuis /ID# 226488

location_facility: Hospital Unversitario Marques de Valdecilla /ID# 226239

location_facility: FutureSearch Trials of Neurology /ID# 226423

location_facility: Kazan State Medical University /ID# 226498

location_facility: Austin Clinical Trial Partners /ID# 228387

location_facility: Re:Cognition Health - Guildford /ID# 226539

location_facility: Specjalistyczne Gabinety Sp. z o.o. /ID# 226266


title: A Phase 2 Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects With Moderately to Severely Active Systemic Lupus Erythematosus

acronym: SLEek

summary: The main objective of this study is to evaluate the safety and efficacy of elsubrutinib, upadacitinib, and ABBV-599 vs placebo for the treatment of signs and symptoms of Systemic Lupus Erythematosus (SLE) in participants with moderately to severely active SLE and to define doses for further development.

ReferenceCitation: Hannon CW, McCourt C, Lima HC, Chen S, Bennett C. Interventions for cutaneous disease in systemic lupus erythematosus. Cochrane Database Syst Rev. 2021 Mar 9;3:CD007478. doi: 10.1002/14651858.CD007478.pub2.

lead_sponsor: AbbVie

location_country:
Spain
Italy
United Kingdom
United States
Japan
Poland
Australia
Argentina
Puerto Rico
Mexico
Canada
Hungary
China
Germany
Bulgaria
Taiwan
New Zealand
Korea, Republic of
France
Colombia
Netherlands

location_facility: Valerius Medical Group & Research Center /ID# 211599

location_facility: RM Pharma Specialists S.A de C.V. /ID# 211879

location_facility: Medstar Health Research Institute /ID# 213335

location_facility: AZ Arthritis and Rheumotology Research, PLLC /ID# 211329

location_facility: West Broward Rheumatology Associates /ID# 211881

location_facility: IRIS Research and Development, LLC /ID# 213053

location_facility: Vital Medical Center Orvosi es Fogaszati Kozpont /ID# 212796

location_facility: Taipei Medical University Hospital /ID# 221600

location_facility: Arthritis and Rheumatism Associates /ID# 211411

location_facility: St Vincent's Hospital Melbourne /ID# 212311

location_facility: Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 213694

location_facility: Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant Anna /ID# 211861

location_facility: Vrije Universiteit Medisch Centrum /ID# 214424

location_facility: Cambridge University Hospitals NHS Foundation Trust /ID# 213189

location_facility: Hospital Universitario Basurto /ID# 212722

location_facility: WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 212482

location_facility: Hospital Universitario 12 de Octubre /ID# 211757

location_facility: West Texas Clinical Research /ID# 211529

location_facility: Virginia Mason Medical Center /ID# 211457

location_facility: AZ Arthritis and Rheumotology Research, PLLC /ID# 214267

location_facility: Hospital Universitario y Politecnico La Fe /ID# 211720

location_facility: CHU Bordeaux - Hopital Pellegrin /ID# 211832

location_facility: Rheumatology Research Unit Sunshine Coast /ID# 211902

location_facility: Universitaetsklinikum Duesseldorf /ID# 212408

location_facility: National Taiwan University Hospital /ID# 211752

location_facility: Leids Universitair Medisch Centrum /ID# 214413

location_facility: Hospital Interzonal General de Agudos General Jose de San Martin /ID# 211679

location_facility: University of Colorado Hospital /ID# 211314

location_facility: Centro Integral en Reumatologia S.A de C.V /ID# 211876

location_facility: Diex Recherche Sherbrooke Inc. /ID# 217734

location_facility: Beth Israel Deaconess Medical Center /ID# 212321

location_facility: Centro de Investigaciones Medicas Tucuman /ID# 212714

location_facility: Kumamoto Shinto General Hospital /ID# 215347

location_facility: The Lundquist Institute at Harbor-UCLA Medical Center /ID# 213402

location_facility: Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 211858

location_facility: Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 221685

location_facility: ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 215063

location_facility: EIRAKU Internal Medicine Clinic /ID# 215419

location_facility: Deerbrook Medical Associates /ID# 212251

location_facility: National Hospital Organization Asahikawa Medical Center /ID# 213846

location_facility: Ctr Arthritis & Rheumatic Dise /ID# 212326

location_facility: Arthritis & Rheumatic Disease Specialties /ID# 214052

location_facility: NYU Langone Orthopedic Center /ID# 213620

location_facility: Peking Union Medical College Hospital /ID# 211614

location_facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 214522

location_facility: Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 212770

location_facility: Guys and St Thomas NHS Foundation Trust /ID# 211931

location_facility: Seoul National University Hospital /ID# 211740

location_facility: KonKuk University Medical Center /ID# 213410

location_facility: Clinica Universitaria Bolivari /ID# 211897

location_facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 212674

location_facility: NYU Langone Ambulatory Care Brooklyn Heights /ID# 211548

location_facility: Inland Rheum Clin Trials Inc. /ID# 213617

location_facility: Hamilton Health Sciences - McMaster University Medical Centre /ID# 212662

location_facility: Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 216971

location_facility: Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 212195

location_facility: Orszagos Reumatologiai es Fizioterapias Intezet /ID# 211827

location_facility: Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 212146

location_facility: Arthritis & Osteo Medical Ctr /ID# 228235

location_facility: The Center for Rheumatology and Bone Research /ID# 211610

location_facility: Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 211634

location_facility: Hospital Universitario de Galdakao /ID# 212803

location_facility: Rheumatology, Arthritis & Immunology Clinic /ID# 214765

location_facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 212145

location_facility: Manchester University NHS Foundation Trust /ID# 211838

location_facility: Fukushima Medical University Hospital /ID# 213913

location_facility: Trinity Universal Research Associates - Carrollton /ID# 211527

location_facility: Centro de Alta Especialidad en Reumatología e Investigación del Potosí, SC /ID# 212737

location_facility: Guangdong Provincial People's Hospital /ID# 211811

location_facility: Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 212483

location_facility: Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 212532

location_facility: CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 211875

location_facility: Xiangya Hospital Central South University /ID# 212919

location_facility: Medical Care & Research SA de CV /ID# 212682

location_facility: Ctr Int de Reum del Caribe SAS /ID# 211894

location_facility: Taipei Veterans General Hosp /ID# 212216

location_facility: Hospital of the University of Occupational and Environmental Health, Japan /ID# 217548

location_facility: East Bay Rheumatology Medical /ID# 211638

location_facility: University of Iowa Hospitals and Clinics /ID# 215246

location_facility: Centrum Medyczne Pratia Warszawa /ID# 218176

location_facility: Universitair Medisch Centrum Utrecht /ID# 214415

location_facility: Hospital Universitario A Coruna - CHUAC /ID# 211719

location_facility: People's Hospital of Xinjiang /ID# 211821

location_facility: Morales Vargas Centro de Investigacion S.C. /ID# 212946

location_facility: Linkou Chang Gung Memorial Hospital /ID# 211751

location_facility: Instituto de Investigaciones Clinicas Tucuman /ID# 211942

location_facility: St. Josephs Health Care Centre /ID# 212331

location_facility: China Medical University Hospital /ID# 212179

location_facility: Taichung Veterans General Hospital /ID# 211957

location_facility: The Queen Elizabeth Hospital /ID# 211901

location_facility: Wallace Rheumatic Studies Center, LLC /ID# 211600

location_facility: Royal Brisbane and Women's Hospital /ID# 212667

location_facility: Aprillus Asistencia e Investigacion /ID# 211630

location_facility: Huashan Hospital, Fudan University /ID# 213976

location_facility: Centro de Investigacion en Reumatologia CIREEM /ID# 211895

location_facility: Chonnam National University Hospital /ID# 211695

location_facility: Ohio State University - Wexner Medical Center /ID# 211636

location_facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 211988

location_facility: Premier Rheumatology of Oklahoma /ID# 213850

location_facility: Debreceni Egyetem Klinikai Kozpont /ID# 212042

location_facility: CHU Strasbourg - Hopital Civil /ID# 211981

location_facility: Rheumatology and Pulmonary Clinic /ID# 211398

location_facility: Accurate Clinical Management /ID# 213571

location_facility: CHRU Lille - Hopital Claude Huriez /ID# 211829

location_facility: Hospital Universitario Virgen de Valme /ID# 212721


title: Multicentre, Prospective, Randomized, Open-label, Assessor Blinded Study to Evaluate Granulox® Used as Adjunct Therapy to Defined Standard of Care vs. Defined Standard of Care for the Treatment of Predominantly Chronic Venous Leg Ulcers (VLUs)

summary:
The investigation is designed as an open label, randomized, prospective, assessor blinded, multi centre investigation.

254 evaluable subjects will be randomized to either standard of care group or standard of care with Granulox added as an adjunct therapy in predominantly venous leg ulcer subjects. Standard of care wound management will be completed, including wound cleansing, debridement if necessary and application of a suitable dressing and compression system until complete wound closure.

The study will be divided into two phases. Firstly, a two week run-in period to ensure compliance to compression therapy followed by a 20 weeks treatment period starting with randomization and allocation of treatment.

lead_sponsor: Molnlycke Health Care AB

location_country:
Croatia
Poland
United Kingdom
Hungary
France
Germany
Czechia

location_facility: Debreceni Egyetem, Klinikai Kozpont, Borgyogyaszati Klinika

location_facility: Szpital Uniwersytecki nr 1 im. dr. A. Jurasza w Bydgoszczy Poradnia Leczenia Ran Przewleklych

location_facility: MDC Clinic Egészégugyi és Diagnosztikai Központ

location_facility: Department od Dermatology, Venerology and Allergology, University of Essen

location_facility: Technische Universitaet Dresden - Universitaetsklinikum Carl Gustav Carus - Klinik fuer Dermatologie

location_facility: Markhot Ferenc oktatókórház és rendelöintézet

location_facility: Hull University Teaching Hospitals NHS Trust


acronym: PERUSE

title: A Multicenter, Open-Label, Single-Arm Study of Pertuzumab in Combination With Trastuzumab and a Taxane in First Line Treatment of Patients With HER2-Positive Advanced (Metastatic or Locally Recurrent) Breast Cancer

ReferenceCitation: Bachelot T, Ciruelos E, Schneeweiss A, Puglisi F, Peretz-Yablonski T, Bondarenko I, Paluch-Shimon S, Wardley A, Merot JL, du Toit Y, Easton V, Lindegger N, Miles D; PERUSE investigators. Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE). Ann Oncol. 2019 May 1;30(5):766-773. doi: 10.1093/annonc/mdz061.

location_country:
Serbia
Saudi Arabia
Italy
Spain
United Kingdom
Lithuania
Ukraine
Venezuela
Peru
Belgium
Poland
Hong Kong
Portugal
Slovenia
Austria
Australia
Argentina
Uruguay
Israel
Turkey
Mexico
Sweden
Egypt
Brazil
Lebanon
Canada
Hungary
China
Germany
Greece
Estonia
Ecuador
Finland
Algeria
France
Netherlands
Morocco
Pakistan
United Arab Emirates

location_facility: Polyclinique de Blois; Chimiotherapie Ambulatoire

location_facility: Tampere University Hospital; Dept of Oncology

location_facility: IPO do Porto; Servico de Oncologia Medica

location_facility: Kings College Hospital NHS Foundation Trust

location_facility: Hospital Quiron Barcelona; Servicio de Oncologia

location_facility: Hospital Universitario La Paz; Servicio de Oncologia

location_facility: Turku Uni Central Hospital; Oncology Clinics

location_facility: Polyclinique De Courlancy; Centre Radiotherapie Oncologie

location_facility: Hospital of Lithuanian University of Health. Sciences Kaunas Clinics

location_facility: Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia

location_facility: Universitätsklinikum des Saarlandes; Klinik f. Frauenheilkunden und Geburtshilfe

location_facility: Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department

location_facility: Centro Oncologico MD Anderson Internacional; Servicio de Oncologia

location_facility: Hospital San Pedro De Alcantara; Servicio de Oncologia

location_facility: Royal United Hospital; Oncology Department

location_facility: Hospital Ramon y Cajal; Servicio de Oncologia

location_facility: Chaim Sheba Medical Center; Oncology Dept

location_facility: Asst Papa Giovanni XXIII; Oncologia Medica

location_facility: Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional

location_facility: Kyiv City Clinical Oncological Center; Chemotherapy Department

location_facility: HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia

location_facility: Hospital Universitari de Girona Dr. Josep Trueta; Servicio de Oncologia

location_facility: Clinique Onco Des Dentellieres; Chimiotherapie Radiotherapie

location_facility: State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department

location_facility: Mc Haaglanden, Locatie Antoniushove; Interne Geneeskunde

location_facility: Irccs Ospedale San Raffaele;Oncologia Medica

location_facility: Hospital de Sagunto; Servicio de Oncologia

location_facility: Hospital Universitario Miguel Servet; Servicio Oncologia

location_facility: Fundacion Hospital de Alcorcon; Servicio de Oncologia

location_facility: King Abdul Aziz Medical City, King Fahd National Guard; Oncology

location_facility: Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe

location_facility: Institut Paoli Calmettes; Oncologie Medicale

location_facility: Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia

location_facility: Queen Elizabeth Hospital; Clinical Oncology

location_facility: Helsinki University Central Hospital; Oncology Clinics

location_facility: Hospital Virgen de los Lirios; Servicio de Oncologia

location_facility: Hospital de Sao Joao; Servico de Oncologia

location_facility: Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia

location_facility: Hospital Nacional LNS dela Policia Nacional del Perú. Unidad Onco; Deapartamento de Oncología

location_facility: Gynaekologicum Bremen; Prof. Dr. Willibald Schröder

location_facility: Hospital da Luz; Departamento de Oncologia Medica

location_facility: Eastbourne District Hospital; Department of Pharmacy

location_facility: Azienda USL di Ravenna; Unità Operativa di Oncologia Medica

location_facility: Hospital do Espirito Santo; Servico de Oncologia Medica

location_facility: University Hospital of Larissa; Oncology

location_facility: Martini Ziekenhuis; Dept of Internal Medicine

location_facility: Hospital Universitario Virgen Macarena; Servicio de Oncologia

location_facility: Royal Melbourne Hospital; Hematology and Medical Oncology

location_facility: The First Affiliated Hospital of The Fourth Military Medical University (Xijing Hospital)

location_facility: Centre Hospitalier Fleyriat; Oncologie/Hematologie

location_facility: Azienda Ospedaliera San Giuseppe Moscati

location_facility: King Faisal Specialist Hospital & Research Centre; Oncology

location_facility: LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie

location_facility: Chp Saint Gregoire; Cancerologie Radiotherapie

location_facility: Papageorgiou General Hospital; Medical Oncology

location_facility: Zaporozhye Regional Oncology Hospital; Dept of Oncology

location_facility: Huddersfield Royal Infirmary - Pharmacy department

location_facility: Akdeniz University Medical Faculty; Medical Oncology Department

location_facility: Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii

location_facility: Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg

location_facility: Cent.Onkologii-Instytut im. M. S-Curie, Klinika Now. Piersi i Chirurgii Rekon

location_facility: Hospital Clinico Universitario de Valladolid; Servicio de Oncologia

location_facility: Klinikum Esslingen; Klinik für Frauenheilkunde und Geburtshilfe

location_facility: Institut National D'oncologie Sidi Mohammed Ben Abdellah; Anatomopathologie

location_facility: Shaukat Khanum Memorial Cancer Hospital; Department of Oncology

location_facility: Hospital General Universitario de Guadalajara; Servicio de Oncologia

location_facility: Complejo Asistencial Universitario De Burgos; Servicio de Oncologia

location_facility: A.Ö. Lhk; Ii. Medizinische Abt. Mit Schwerpunkt Gaströnter. & Onkologie

location_facility: Hospital Sirio Libanes; Centro de Oncologia

location_facility: Azienda Ospedaliero-Universitaria Dipartimento Interaziendale Di Oncologia

location_facility: American University of Beirut - Medical Center

location_facility: Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für Gynäkologie

location_facility: Hameed Latif Hospital; Department of Oncology

location_facility: Derriford Hospital; Plymouth Oncology Centre

location_facility: Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology

location_facility: Centre Rene Huguenin; ONCOLOGIE GENETIQUE

location_facility: Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia

location_facility: Ospedale Maggiore Della Carita; Oncologia Medica

location_facility: Twee Steden Ziekenhuis - Locatie Tilburg; Interne Geneesekunde

location_facility: Orszagos Onkologial Intezet; Onkologiai Osztaly X

location_facility: Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia

location_facility: Borsod-Abauj-Zemplen Megyei Korhaz Es Egyetemi Oktato Korhaz; Onkologiai Osztaly

location_facility: Irccs Policlinico S. Matteo - Uni Pavia; Clinica Medica I Div. Med. Int. Onc. Medica E Gastroent.

location_facility: Corporacio Sanitaria Parc Tauli; Servicio de Oncologia

location_facility: Centre Georges Francois Leclerc; Oncologie 3

location_facility: Queen Elizabeth II Health Sciences Centre; Oncology

location_facility: Hospital de Rio Hortega; Servicio de Oncologia

location_facility: Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.

location_facility: Universitätsklinikum Essen; Zentrum Für Frauenheilkunde

location_facility: University Hospital of Patras Medical Oncology

location_facility: Hospital Universitario 12 de Octubre; Servicio de Oncologia

location_facility: Hospital Pereira Rossell; Oncology Department

location_facility: Centre Azureen De Cancerologie; Cons externes

location_facility: Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia

location_facility: First Affiliated Hospital of Medical College of Xi'an Jiaotong University

location_facility: Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii; Poradnia Chemioterapii

location_facility: Hospital General Universitario J.M Morales Meseguer; Servicio de Oncologia

location_facility: Catharina ZKHS; Inwendige Geneeskunde Afd.

location_facility: Leeds Teaching Hosp NHS Trust;St James's Institute of Onc

location_facility: SRH Wald-Klinikum Gera; Klinik für Frauenheilkunde und Geburtshilfe

location_facility: Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie

location_facility: Hospital General de Elda; Servicio de Oncologia

location_facility: Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika

location_facility: Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1

location_facility: Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej

location_facility: Bcca - Vancouver Island Cancer Centre; Oncology

location_facility: Royal Prince Alfred Hospital; Medical Oncology

location_facility: IPO de Coimbra; Servico de Oncologia Medica

location_facility: Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia

location_facility: Fundacion Jimenez Diaz; Servicio de Oncologia

location_facility: Fovarosi Szent Laszlo Korhaz-Rendelointezet; Onkologiai Osztaly X

location_facility: Skånes University Hospital, Skånes Department of Onclology

location_facility: Institut Claudius Regaud; Departement Oncologie Medicale

location_facility: Klinikum rechts der Isar der TU München; Klinik und Poliklinik für Frauenheilkunde

location_facility: Hospital Beatriz Angelo; Departamento de Oncologia

location_facility: Centre Hospitalier de l'Université de Montréal (CHUM)

location_facility: Ospedale Degli Infermi Di Biella; Reparto Oncologia Medica

location_facility: Ospedale Mater Salutis; Dept of Oncology

location_facility: Clinica Universitaria de Navarra; Servicio de Oncologia

location_facility: Lkh-Univ. Klinikum Graz; Klinik Für Gynäkologie

location_facility: Hospital de Santa Maria; Servico de Oncologia Medica

location_facility: Centro Médico Docente La Trinidad; Servicio de Gastroenterología

location_facility: Hospital Clinico Universitario de Salamanca; Servicio de Oncologia

location_facility: Christie Hospital; Breast Cancer Research Office

location_facility: Centro Oncologico Riojano Integral (CORI)

location_facility: Anticancer Hospital Ag. Savas ; 2Nd Dept. of Oncology - Internal Medicine

location_facility: Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding

location_facility: Szent Margit Hospital; Dept. of Oncology

location_facility: Västmanlands sjukhus Västerås, Onkologkliniken

location_facility: Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie

location_facility: Hospital Universitario Clínico San Carlos; Servicio de Oncologia

location_facility: Hospital General de México; Unidad de Oncologia

location_facility: Cross Cancer Institute ; Dept of Medical Oncology

location_facility: Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

location_facility: Ege University Medical Faculty; Medical Oncology Department

location_facility: Debreceni Egyetem Klinikai Kozpont ; Department of Oncology

location_facility: Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia

location_facility: Hopital Cochin; Unite Fonctionnelle D Oncologie

location_facility: Hacettepe Uni Medical Faculty Hospital; Oncology Dept

location_facility: Uni Oncology Inst. ; Chemo - Radiation Dept

location_facility: Hadassah Ein Karem Hospital; Oncology Dept

location_facility: Mun. Multifield Clin.Hosp.#4,Dept. of Chemotherapy, DSMU; Chair of Oncology and Medical Radiology

location_facility: Hospital Universitari Sant Joan de Reus; Servicio de Oncologia

location_facility: Hospital de Navarra; Servicio de Oncologia

location_facility: Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia

location_facility: Shifa International Hospital; Department of Oncology

location_facility: Clinique De L Europe; Radiotherapie Chimiotherapie

location_facility: Hospital Clínic i Provincial; Servicio de Hematología y Oncología

location_facility: Euromedical General Clinic of Thessaloniki; Oncology Department

location_facility: Fondazione Del Piemonte; Medical Oncology

location_facility: Kreiskrankenhaus Torgau; Abt.Gynäkologie und Geburtshilfe

location_facility: McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology

location_facility: Ordensklinikum Linz Barmherzige Schwestern; Abt. fur Innere Medizin 1

location_facility: Sourasky / Ichilov Hospital; Dept. of Oncology

location_facility: Instituto Nacional de Cancerologia; Oncology

location_facility: Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie

location_facility: Complejo Asistencial Universitario de Leon; Servicio de Oncologia

location_facility: Shaare Zedek Medical Center; Oncology Dept

location_facility: Complejo Hospitalario San Millan - San Pedro; Servicio de Oncologia

location_facility: Hopital Saint Louis; Service Onco Thoracique

location_facility: Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología

location_facility: Freeman Hospital; Northern Centre For Cancer Care

location_facility: North Estonia Medical Centre Foundation; Oncology Center

location_facility: Hospital de Basurto; Servicio de Oncologia

location_facility: Consultorio de Medicina Especializada; Dentro de Condominio San Francisco

location_facility: Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii

location_facility: Hopital Prive Drome Ardeche; Hopital De Jour

location_facility: University General Hospital of Heraklion

location_facility: Centre Leon Berard; Departement Oncologie Medicale

location_facility: Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe

location_facility: Ente Ospedaliero Ospedali Galliera; S.C. Oncologia Medica

location_facility: Hospital de Cabueñes; Servicio de Oncologia

location_facility: Hospital Severo Ochoa; Servicio de Oncologia

location_facility: Complejo Hospitalario de Orense; Servicio de Oncologia

location_facility: Tartu University Hospital; Clinic of Hematology and Oncology

location_facility: Clinique Sainte Marguerite; Oncologie Medicale

location_facility: William Osler Health System Brampton Civic Hospital

location_facility: Hospital de Barbastro; Servicio de Oncologia

location_facility: Hospital de Jerez de la Frontera; Servicio de Oncologia

location_facility: Hospital Universitario Virgen de las Nieves; Servicio de Oncologia

location_facility: Centro Medico Nacional Siglo Xxi - Imss; Hospital de Oncologia

location_facility: Hospital Central De Las FF.AA.; Servicio De Oncologia

location_facility: Instituto Nacional de Ciencias Médicas Y de La Nutricion Zubirán

location_facility: Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia

location_facility: Austin and Repatriation Medical Centre; Cancer Services

location_facility: Hospital Provincial de Castellon; Servicio de Oncologia

location_facility: Southwest Hospital , Third Military Medical University

location_facility: Centro Clinico Champalimaud; Oncologia Medica

location_facility: Świętokrzyskie Centrum Onkologii; Dział Chemioterapii

location_facility: Hippokratio Hospital; 2Nd Internal Medicine

summary: This multicenter, open-label, single-arm, Phase IIIb study will evaluate the safety and tolerability of pertuzumab in combination with trastuzumab (Herceptin) and a taxane (docetaxel, paclitaxel or nab-paclitaxel) in first-line treatment in participants with metastatic or locally recurrent HER2-positive breast cancer. Participants will receive pertuzumab intravenously (IV) and trastuzumab (Herceptin) IV plus a taxane in cycles of 3 weeks each until predefined study end, unacceptable toxicity, withdrawal of consent, disease progression, or death, whichever occurs first.


title: An Open-label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease (PD) in Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC) After First Line Treatment With Bevacizumab Plus a Platinum Doublet-containing Chemotherapy

ReferenceCitation: Gridelli C, de Castro Carpeno J, Dingemans AC, Griesinger F, Grossi F, Langer C, Ohe Y, Syrigos K, Thatcher N, Das-Gupta A, Truman M, Donica M, Smoljanovic V, Bennouna J. Safety and Efficacy of Bevacizumab Plus Standard-of-Care Treatment Beyond Disease Progression in Patients With Advanced Non-Small Cell Lung Cancer: The AvaALL Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):e183486. doi: 10.1001/jamaoncol.2018.3486. Epub 2018 Dec 13. Erratum in: JAMA Oncol. 2018 Dec 1;4(12):1792.

ReferenceCitation: Takeda M, Yamanaka T, Seto T, Hayashi H, Azuma K, Okada M, Sugawara S, Daga H, Hirashima T, Yonesaka K, Urata Y, Murakami H, Saito H, Kubo A, Sawa T, Miyahara E, Nogami N, Nakagawa K, Nakanishi Y, Okamoto I. Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial. Cancer. 2016 Apr 1;122(7):1050-9. doi: 10.1002/cncr.29893. Epub 2016 Feb 1.

ReferenceCitation: Gridelli C, Bennouna J, de Castro J, Dingemans AM, Griesinger F, Grossi F, Rossi A, Thatcher N, Wong EK, Langer C. Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rationale and protocol dynamics of the AvaALL (MO22097) trial. Clin Lung Cancer. 2011 Nov;12(6):407-11. doi: 10.1016/j.cllc.2011.05.002. Epub 2011 Jun 25.

location_country:
Denmark
Brazil
Spain
Greece
Austria
Italy
Lebanon
Argentina
Mexico
Netherlands
Oman
United States
France
Belgium
Japan
Germany
Slovakia
United Arab Emirates

location_facility: Hematology & Oncology Assoc; North Eastern Pennsylvania

location_facility: Inst. of Tb & Respiratory Diseases; Dep. of Oncology

location_facility: Hospital Universitario La Paz; Servicio de Oncologia

location_facility: Aichi Cancer Center Hospital; Respiratory Medicine

location_facility: National Cancer Center Hospital East; Thoracic Oncology

location_facility: The Cancer Institute Hospital of JFCR, Respiratory Medicine

location_facility: Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie

location_facility: SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie

location_facility: SMZ - Baumgartner Hohe, Pavilion Leopold; 1.Interne Lungenabteilung, Onkologische Tagesklinik

location_facility: Osaka International Cancer Institute; Thoracic Oncology

location_facility: Hospital Universitario Miguel Servet; Servicio Oncologia

location_facility: Nordsjællands Hospital, Hillerød, Onkologisk Afdeling

location_facility: University of Pennsylvania; Radiation Oncology

location_facility: Centro de Pesquisa Clínica- Instituto do Câncer do Ceará- ICC

location_facility: Heartland CCOP/Missouri Baptist Medical Center

location_facility: Stony Brook Univ Cancer Ctr; Medical Oncology Clinic

location_facility: East Valley Hematology ; Oncology Medical Group

location_facility: Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin I

location_facility: Centro de Estudos e Pesquisas Oncologicas - CESPO

location_facility: Ch Lyon Sud; Chir Onc Gyne Sct Jules Courmont

location_facility: Hospital Central Sur de Alta Especialidad Petróleos Mexicanos

location_facility: Cancer Care & Hematology; Specialists of Chicagoland

location_facility: Signal Point Clinical; Research Center, LLC

location_facility: Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica

location_facility: Metropolitan Hospital; 2Nd Oncology Clinic

location_facility: National Hospital Organization Shikoku Cancer Center; Thoracic Oncology

location_facility: University of Tennessee Medical Center Cancer Institute

location_facility: Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia

location_facility: Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie

location_facility: Az. Osp. Di Busto P.O. Di Saronno; U.O. Di Oncologia Medica

location_facility: American University of Beirut - Medical Center

location_facility: Sociedade beneficente de senhoras Hospital Sirio Libanes

location_facility: Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1

location_facility: Krankenhaus Der Stadt Wien Lainz; V. Medizinische Abt.

location_facility: National Cancer Center Hospital; Thoracic Medical Oncology

location_facility: Henry Ford Hospital; Hematology Oncology

location_facility: Zentralklinik Bad Berka GmbH; Pneumologie

location_facility: IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A

location_facility: Centro Médico Abc the American British Cowdray Medical Center, I.A.P. - Centro de Cáncer

location_facility: National Hospital Organization Kyushu Cancer Center, Thoracic Oncology

location_facility: Pius-Hospital; Klinik fuer Haematologie und Onkologie

location_facility: Okayama University Hospital; Respiratory and Allergy Medicine

location_facility: Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie

location_facility: Citta Ospedaliera; Divisione Oncologia Medica

location_facility: Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie

location_facility: IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A

location_facility: Joliet Oncology Hematology Associates, Ltd.

location_facility: Hospital de Cruces; Servicio de Oncologia

location_facility: St. Vincentius Kliniken Karlsruhe; Abteilung Hämatologie / Onkologie

location_facility: Shizuoka Cancer Center; Thoracic Oncology

location_facility: Tawam Hospital; Medical Oncology Department

location_facility: Carolina Oncology Specialists, PA - Hickory

location_facility: Hospital Universitario Dr. Peset; Servicio de Oncologia

location_facility: Centre Hospitalier Intercommunal; Service de Pneumologie

location_facility: Hospital General Univ. de Alicante; Servicio de Oncologia

location_facility: Fnsp Fdr Banska Bystrica; Dep of Pneumology&Ftizeology

location_facility: Miyagi Cancer Center; Respiratory Medicine

location_facility: A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii

location_facility: General Hospital of Thessaloniki Papanikolaou; Uni Pneumonology Dept.

location_facility: Oncology-Evanston Nthwest Healthcare Kellogg Cancer Care Ctr

location_facility: Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire

location_facility: College of Medicine & Sciences, Sultan Qaboos University Hospital

location_facility: Chi De La Haute Saone De Vesoul; Pneumologie

location_facility: Hospital Universitario Clínico San Carlos; Servicio de Oncologia

location_facility: Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)

location_facility: Eastern Ct Hema/Onco Assoc; Dept of Oncology

location_facility: Lkh Natters; Abt. Für Atemwegs- & Lungenkrankheiten

location_facility: OSAKA CITY GENERAL HOSPITAL;Medical Oncology

location_facility: Ziekenhuis St Jansdal; Dept of Lung Diseases

location_facility: Universitaetsklinikum des Saarlandes; Innere Medizin V

location_facility: Catharina Ziekenhuis; Dept of Lung Diseases

location_facility: California Cancer Associates for Research & Excellence, Inc.

location_facility: Ludwig-Maximilians Uni Klinik Innenstadt; Medizinische Klinik

location_facility: Yokohama Municipal Citizen'S Hospital; Respiratory

location_facility: Centro Oncologico MD Anderson International Espana

location_facility: Cancer & Hematology Center of West Michigan

location_facility: Oncology Hematology Associates of Southwest Indiana

location_facility: Antonius Ziekenhuis; Dept of Lung Diseases

location_facility: Anne Arundel Health System Research Instit-Annapolis Oncology Ctr

location_facility: Hôpital Saint Joseph; Oncologie Medicale

location_facility: UNI OF WISCONSIN SCHOOL OF MEDICINE; GI Oncology Research Group, Paul P Carbone Cancer Center

location_facility: Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique

location_facility: Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik

location_facility: Kanagawa Cardiovascular and Respiratory Center; Respiratory Medicine

location_facility: Tufts Medical Center; Neely Cancer Center

summary: This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Participants will be enrolled at documentation of progression of disease (PD) after 4-6 cycles of first-line treatment with bevacizumab plus a platinum doublet-containing therapy and a minimum of two cycles of bevacizumab maintenance treatment prior to PD. Participants will be randomly assigned to one of two treatment arms to receive either bevacizumab plus SOC treatment or SOC treatment alone.


title: A Phase 1b, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Subjects With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

summary: The main objective of this study is to assess safety, tolerability, and pharmacokinetics (PK) of ABBV-368 plus tilsotolimod; ABBV-368 plus tilsotolimod and nab-paclitaxel; and ABBV-368 plus tilsotolimod, nab-paclitaxel, and ABBV-181 in participants with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).

location_country:
Spain
United States
Israel
France
Netherlands
Germany

location_facility: Vanderbilt Ingram Cancer Center /ID# 214040

location_facility: Hospital Universitario de Fuenlabrada /ID# 214263

location_facility: Centre Antoine Lacassagne - Nice /ID# 215706

location_facility: Universitaetsklinikum Erlangen /ID# 214196

location_facility: Hospital Clinico Universitario de Valencia /ID# 221401

location_facility: Hospital Universitario HM Sanchinarro /ID# 214110

location_facility: The University of Chicago Medical Center /ID# 217196

location_facility: Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 214197

location_facility: Roswell Park Comprehensive Cancer Center /ID# 215882

location_facility: Hospital Universitario 12 de Octubre /ID# 214198

location_facility: Hospital Clinic de Barcelona /ID# 214264

location_facility: The Chaim Sheba Medical Center /ID# 215229

location_facility: Gastroenterology Institute, Division of Medicine /ID# 215862

location_facility: AP-HM - Hopital de la Timone /ID# 215657

location_facility: Universitaetsklinikum Leipzig /ID# 214200

location_facility: Instituto Catalan de Oncologia (ICO) L'Hospitalet /ID# 221402

location_facility: Hospital Universitario Virgen de la Victoria /ID# 214109

location_facility: Barbara Ann Karmanos Cancer In /ID# 214050


title: A Phase 3, Randomized, Open-label, Multicenter Study Comparing Ponatinib Versus Imatinib, Administered in Combination With Reduced-Intensity Chemotherapy, in Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

lead_sponsor: Takeda

type: Other Identifier

type: Registry Identifier

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement.

location_country:
Poland
Taiwan
Brazil
Spain
Greece
Austria
Australia
Italy
Argentina
Canada
Finland
Russian Federation
Korea, Republic of
United States
France
China
Turkey
Mexico
Japan
Bulgaria

location_facility: Institute of Hematology & Blood Diseases Hospital of CAMS & PUMC

location_facility: Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi

location_facility: Augusta University Georgia Cancer Center

location_facility: Fondazione Policlinico Universitario Agostino Gemelli

location_facility: National Research Center for Hematology, Dept. of Hematology/Oncology and BMT

location_facility: Azienda Ospedaliero-Universitaria di Modena Policlinico

location_facility: Hanusch Krankenhaus Wiener Gebietskrankenkasse

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: Hospital Universitario Dr. Jose Eleuterio Gonzalez

location_facility: Helsingin ja Uudenmaan sairaanhoitopiiri

location_facility: Hospital Universitari i Politecnic La Fe de Valencia

location_facility: Institut Universitaire du Cancer de Toulouse Oncopole

location_facility: Fundacao Antonio Prudente - A.C.Camargo Cancer Center

location_facility: Universitaetsklinik Fuer Innere Medizin I

location_facility: Centre Hospitalier de Versailles Hopital Andre Mignot

location_facility: Hospital Privado Centro Medico de Cordoba

location_facility: Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych z Warminsko-Mazurs

location_facility: University General Hospital of Patras Panagia I Voithia

location_facility: Institut Catala d'Oncologia Badalona - Hospital Germans Trias i Pujol

location_facility: City Clinical Hospital named after Vikentiy Vikentyevich Veresaev

location_facility: Istituto Scientifico Universitario San Raffaele

location_facility: Sverdlovsk Regional Clinical Hospital #1

location_facility: Almazov Federal North-West Medical Research Centre of Department of Health of Russian Federation

location_facility: Azienda Ospedaliera San Gerardo di Monza

location_facility: Center Hospitalier Universitaire d'Angers

location_facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

location_facility: HEMORIO Instituto Estadual de Hematologia

location_facility: The First Affiliated Hospital of Soochow University/Suzhou First People's Hospital

location_facility: The Catholic University of Korea St. Vincent's Hospital

location_facility: University General Hospital of Athens Attikon

location_facility: Instituto do Cancer do Estado de Sao Paulo

location_facility: University of Kansas Medical Center Research Institute

location_facility: Centro di Ematologia Policlinico Umberto I Universita Sapienza di Roma

location_facility: The First Affiliated Hospital, Zhejiang University

location_facility: Hospital das Clinicas da Faculdade de Medicina da Riberao Preto da Universidade de Sao Paulo

location_facility: Uniwersytecki Szpital Kliniczny we Wroclawiu

location_facility: University Multiprofile Hospital for Active Treatment Saint Ivan Rilski

summary:
In this study, adults with newly-diagnosed Philadelphia Chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) will receive first-line therapy of ponatinib or imatinib.

The main aim of this study is to compare the number of participants on each treatment that show no signs of disease.

Participants will take tablets of either ponatinib or imatinib at the same time each day combined with reduced-intensity chemotherapy for up to 20 months. Then, they will continue with single-agent therapy (ponatinib or imatinib) until they meet the discontinuation criteria from the study.


title: A Phase 2, Open-Label Study of Ixazomib+Daratumumab+Dexamethasone (IDd) in Relapsed and/or Refractory Multiple Myeloma (RRMM)

summary: The purpose of this study is to evaluate the percentage of participants with a response of very good partial response (VGPR) or better to IDd treatment.

status: Active, not recruiting

ipd_sharing_description: Takeda provides access to the de-identified individual participant data (IPD) for eligible studies to aid qualified researchers in addressing legitimate scientific objectives (Takeda's data sharing commitment is available on https://clinicaltrials.takeda.com/takedas-commitment?commitment=5). These IPDs will be provided in a secure research environment following approval of a data sharing request, and under the terms of a data sharing agreement

location_country:
Poland
Greece
United States
France
Netherlands
Czechia

location_facility: SCRI - Florida Cancer Specialists - Panhandle

location_facility: SCRI - Tennessee Oncology - Nashville - Centennial

location_facility: Szpitale Pomorskie Spolka z ograniczona odpowiedzialnoscia

location_facility: Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza

location_facility: Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

location_facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich

location_facility: University General Hospital of Patras Panagia I Voithia

location_facility: The University of Texas MD Anderson Cancer Center

location_facility: Onkologicka klinika Vseobecna fakultni nemocnice v Praze a 1


title: A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors

summary: The primary purpose of this Phase 1, open-label study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of ABBV-368 as a monotherapy and in combination with ABBV-181 in participants with locally advanced or metastatic solid tumors. The study will consist of 3 parts: ABBV-368 dose escalation, ABBV-368 tumor-specific dose expansion (triple negative breast cancer [TNBC] cohort and head and neck cancer cohort) and 18F-AraG Imaging Substudy.

location_country:
Taiwan
Spain
Puerto Rico
United States
France
Japan

location_facility: National Cancer Center Hospital /ID# 214531

location_facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 211500

location_facility: National Taiwan University Hospital /ID# 164000

location_facility: Taipei Medical University Hospital /ID# 164001

location_facility: University of Texas Southwestern Medical Center /ID# 201934

location_facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 206973

location_facility: National Cancer Center Hospital East /ID# 214530

location_facility: Hospital Clinico Universitario de Valencia /ID# 211499

location_facility: Moores Cancer Center at UC San Diego /ID# 201334

location_facility: Virginia Cancer Specialists - Fairfax /ID# 160787

location_facility: CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 205996

location_facility: CLINICA UNIVERSIDAD DE NAVARRA-Pamplona /ID# 208879

location_facility: University of California, Davis Comprehensive Cancer Center /ID# 201342

location_facility: Pan American Center for Oncology Trials, LLC /ID# 213809

location_facility: National Cheng Kung University Hospital /ID# 164002

location_facility: AP-HM - Hopital de la Timone /ID# 165036

location_facility: Carolina BioOncology Institute /ID# 160786

location_facility: Hospital General Universitario Gregorio Maranon /ID# 205999

location_facility: South Texas Accelerated Research Therapeutics /ID# 160788