CCDC 1916786: Experimental Crystal Structure Determination;Filipović, Nenad R.;2019;Cambridge Crystallographic Data Centre

Related Article: Nenad R. Filipović, Predrag Ristić, Goran Janjić, Olivera Klisurić, Adrián Puerta, José M. Padrón, Morgan Donnard, Mihaela Gulea, Tamara R. Todorović|2019|Polyhedron|173|114132|doi:10.1016/j.poly.2019.114132


Abstract: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 2178080: Experimental Crystal Structure Determination;Hessin, Cheriehan;2023;Cambridge Crystallographic Data Centre

Related Article: Cheriehan Hessin, Jules Schleinitz, Nolwenn Le Breton, Sylvie Choua, Laurence Grimaud, Vincent Fourmond, Marine Desage-El Murr, Christophe Léger|2023|Inorg.Chem.|62|3321|doi:10.1021/acs.inorgchem.2c04365


CCDC 2340270: Experimental Crystal Structure Determination;Vorobyeva, Sofia N.;2024;Cambridge Crystallographic Data Centre

Related Article: Sofia N. Vorobyeva, Sof'ya A. Bautina, Nikita A. Shekhovtsov, Elena B. Nikolaenkova, Taisiya S. Sukhikh, Yuliya A. Golubeva, Lyubov S. Klyushova, Viktor P. Krivopalov, Marianna I. Rakhmanova, Christophe Gourlaouen, Mark B. Bushuev|2024|Dalton Trans.|53|8398|doi:10.1039/D4DT00824C


CCDC 1505778: Experimental Crystal Structure Determination;Renard, Nicolas;2019;Cambridge Crystallographic Data Centre

Related Article: Nicolas Renard,  Eric Brenner,  Dominique Matt,  Christophe Gourlaouen|2019|Eur.J.Inorg.Chem.|2019|2996|doi:10.1002/ejic.201900571


CCDC 1505779: Experimental Crystal Structure Determination;Renard, Nicolas;2019;Cambridge Crystallographic Data Centre


Abstract: Abstract Background Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation patterns during male germ cell differentiation have been associated with infertility in several species. While bull semen is widely used in artificial insemination, the literature describing DNA methylation in bull spermatozoa is still scarce. The purpose of this study was therefore to characterize the bull sperm methylome relative to both bovine somatic cells and the sperm of other mammals through a multiscale analysis. Results The quantification of DNA methylation at CCGG sites using luminometric methylation assay (LUMA) highlighted the undermethylation of bull sperm compared to the sperm of rams, stallions, mice, goats and men. Total blood cells displayed a similarly high level of methylation in bulls and rams, suggesting that undermethylation of the bovine genome was specific to sperm. Annotation of CCGG sites in different species revealed no striking bias in the distribution of genome features targeted by LUMA that could explain undermethylation of bull sperm. To map DNA methylation at a genome-wide scale, bull sperm was compared with bovine liver, fibroblasts and monocytes using reduced representation bisulfite sequencing (RRBS) and immunoprecipitation of methylated DNA followed by microarray hybridization (MeDIP-chip). These two methods exhibited differences in terms of genome coverage, and consistently, two independent sets of sequences differentially methylated in sperm and somatic cells were identified for RRBS and MeDIP-chip. Remarkably, in the two sets most of the differentially methylated sequences were hypomethylated in sperm. In agreement with previous studies in other species, the sequences that were specifically hypomethylated in bull sperm targeted processes relevant to the germline differentiation program (piRNA metabolism, meiosis, spermatogenesis) and sperm functions (cell adhesion, fertilization), as well as satellites and rDNA repeats. Conclusions These results highlight the undermethylation of bull spermatozoa when compared with both bovine somatic cells and the sperm of other mammals, and raise questions regarding the dynamics of DNA methylation in bovine male germline. Whether sperm undermethylation has potential interactions with structural variation in the cattle genome may deserve further attention.

A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific features;Jean-Philippe Perrier;2018;figshare

Biological Sciences not elsewhere classified


Abstract: Abstract Background Lyme borreliosis in humans results in a range of clinical manifestations, thought to be partly due to differences in the pathogenicity of the infecting strain. This study compared European human clinical strains of Borreliella afzelii (previously named Borrelia afzelii) using multilocus sequence typing (MLST) to determine their spatial distribution across Europe and to establish whether there are associations between B. afzelii genotypes and specific clinical manifestations of Lyme borreliosis. For this purpose, typing was performed on 63 strains, and data on a further 245 strains were accessed from the literature. Results All 308 strains were categorized into 149 sequence types (STs), 27 of which are described here for the first time. Phylogenetic and goeBURST analyses showed short evolutionary distances between strains. Although the main STs differed among the countries with the largest number of strains of interest (Germany, the Netherlands, France and Slovenia), the B. afzelii clinical strains were less genetically structured than those previously observed in the European tick population. Two STs were found significantly more frequently in strains associated with clinical manifestations involving erythema migrans, whereas another ST was found significantly more frequently in strains associated with disseminated manifestations, especially neuroborreliosis. Conclusions The MLST profiles showed low genetic differentiation between B. afzelii strains isolated from patients with Lyme borreliosis in Europe. Also, clinical data analysis suggests the existence of lineages with differential dissemination properties in humans.

Environmental Sciences not elsewhere classified

Multilocus sequence typing of clinical Borreliella afzelii strains: population structure and differential ability to disseminate in humans;Floriane Gallais;2018;figshare


Abstract: Abstract Background Oxidative stress (OS) plays an important role in type 2 diabetes (T2D) pathogenesis and its complications. New therapies target natural antioxidants as an alternative and/or supplemental strategy to prevent and control them. Our previous chemical and biological studies highlighted the important antioxidant activities of cherries, among other fruits and vegetables, thus we aimed to determine in vivo effects of 2-month long cherry consumption using a high-fat/high-fructose (HFHF) model of diabetic-rats (Lozano et al. in Nutr Metab 13:15, 2016). Methods After 2 months of HFHF, male Wistar rats were divided into: HFHF and HFHF enriched in cherry (nutritional approach) or standard diet ND (lifestyle measures) and ND plus cherry during 2 months. Metabolic, lipidic, oxidative parameters were quantified. Tissues (liver, pancreas and vessels) OS were assessed and hepatic (steatosis, fibrosis, inflammation) and vascular (endothelial dysfunction) complications were characterized. Results T2D was induced after 2 months of HFHF diet, characterized by systemic hyperglycaemia, hyperinsulinemia, glucose intolerance, dyslipidaemia, hyperleptinemia, and oxidative stress associated with endothelial dysfunction and hepatic complications. Cherry consumption for 2 months, in addition to lifestyle measures, in T2D-rats decreased and normalized the systemic disturbances, including oxidative stress complications. Moreover, in the vessel, cherry consumption decreased oxidative stress and increased endothelial nitric oxide (NO) synthase levels, thus increasing NO bioavailability, ensuring vascular homeostasis. In the liver, cherry consumption decreased oxidative stress by inhibiting NADPH oxidase subunit p22phox expression, nuclear factor erythroid-2 related factor 2 (Nrf2) degradation and the formation of reactive oxygen species. It inhibited the activation of sterol regulatory element-binding proteins (1c and 2) and carbohydrate-responsive element-binding protein, and thus decreased steatosis as observed in T2D rats. This led to the improvement of metabolic profiles, together with endothelial and hepatic function improvements. Conclusion Cherry consumption normalized vascular function and controlled hepatic complications, thus reduced the risk of diabetic metabolic disorders. These results demonstrate that a nutritional intervention with a focus on OS could prevent and/or delay the onset of vascular and hepatic complications related to T2D.

Chemical Sciences not elsewhere classified

Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats;Remmelt Werf;2018;figshare


Abstract: Abstract Background Bowel ischemia is a life-threatening emergency defined as an inadequate vascular perfusion leading to bowel inflammation resulting from impaired colonic/small bowel blood supply. Main issue for physicians regarding bowel ischemia diagnosis lies in the absence of informative and specific clinical or biological signs leading to delayed management, resulting in a poorer prognosis, especially after cardiac surgery. The aim of the present series was to propose a simple scoring system based on biological data for the diagnosis of bowel ischemia. Methods In a retrospective monocentric study, patients admitted in cardiac ICU, after cardiovascular surgery, were screened for inclusion. According to a 1:2 ratio (case–control), matching between two groups was based on sex, type of cardiovascular surgery, and the operative period (per month). Patients were divided into two groups: “ischemic group” which corresponds to patients with confirmed bowel ischemia and “non-ischemic group” which corresponds to patients without bowel ischemia. Primary objective was the conception of a scoring system for the diagnosis of bowel ischemia. Secondary objectives were to detail the postoperative morbidity and the diagnostic features for the distinction between acute mesenteric ischemia and ischemic colitis. Results Forty-eight patients (1.3%) had confirmed bowel ischemia (“ischemic group”). According to the 2:1 matching, 96 patients were included in the “non-ischemic group.” Aspartate aminotransferase > 449 UI/L, lactate > 4 mmol/L, procalcitonin > 4.7 μg/L, and myoglobin > 1882 μg/L were found to be independently associated with bowel ischemia. Based on their respective odds ratios, points were assigned to each item ranging from 4 to 8. AUROCC [95% confidence interval] of the scoring system to diagnose bowel ischemia was 0.93 [0.91–0.95], p < 0.001. The optimal threshold after bootstrapping was ≥ 14 points; this yielded a sensitivity of 85.4%, a specificity of 94.8%, a positive likelihood ratio of 16.42, a negative likelihood ratio of 0.15, a Youden’s index of 0.802, and a diagnostic odds ratio of 106.62. Conclusions A biological scoring system based on PCT, ASAT, lactate, and myoglobin measurement allows the diagnosis of bowel ischemia after cardiac surgery with high accuracy. This score could help clinician to propose an early diagnosis and an early treatment in this high mortality disease.

Mathematical Sciences not elsewhere classified

Biological scoring system for early prediction of acute bowel ischemia after cardiac surgery: the PALM score;Elie Zogheib;2018;figshare


Abstract: Abstract Background Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are vectors of bluetongue virus (BTV), African horse sickness virus and Schmallenberg virus (SBV). Outbreaks of both BTV and SBV have affected large parts of Europe. The spread of these diseases depends largely on vector distribution and abundance. The aim of this analysis was to identify and quantify major spatial patterns and temporal trends in the distribution and seasonal variation of observed Culicoides abundance in nine countries in Europe. Methods We gathered existing Culicoides data from Spain, France, Germany, Switzerland, Austria, Denmark, Sweden, Norway and Poland. In total, 31,429 Culicoides trap collections were available from 904 ruminant farms across these countries between 2007 and 2013. Results The Obsoletus ensemble was distributed widely in Europe and accounted for 83% of all 8,842,998 Culicoides specimens in the dataset, with the highest mean monthly abundance recorded in France, Germany and southern Norway. The Pulicaris ensemble accounted for only 12% of the specimens and had a relatively southerly and easterly spatial distribution compared to the Obsoletus ensemble. Culicoides imicola Kieffer was only found in Spain and the southernmost part of France. There was a clear spatial trend in the accumulated annual abundance from southern to northern Europe, with the Obsoletus ensemble steadily increasing from 4000 per year in southern Europe to 500,000 in Scandinavia. The Pulicaris ensemble showed a very different pattern, with an increase in the accumulated annual abundance from 1600 in Spain, peaking at 41,000 in northern Germany and then decreasing again toward northern latitudes. For the two species ensembles and C. imicola, the season began between January and April, with later start dates and increasingly shorter vector seasons at more northerly latitudes. Conclusion We present the first maps of seasonal Culicoides abundance in large parts of Europe covering a gradient from southern Spain to northern Scandinavia. The identified temporal trends and spatial patterns are useful for planning the allocation of resources for international prevention and surveillance programmes in the European Union.

Spatial and temporal variation in the abundance of Culicoides biting midges (Diptera: Ceratopogonidae) in nine European countries;Ana Cuéllar;2018;figshare


Abstract: DNA, RNA and histones methylation is implicated in various human diseases such as cancer or viral infections playing a major role in cell process regulations especially in modulation of gene expression. Here we developed a convergent synthetic pathway starting from a protected bromomethylcytosine derivative to synthesize transition state analogues of the DNA methyltransferases. This approach led to seven 5-methylcytosine-adenosine compounds that resulted, surprisingly, inactive against hDNMT1, hDNMT3Acat, TRDMT1, and other RNA human and viral methyltransferases. Interestingly, compound 4 and its derivative 2 showed an inhibitory activity against PRMT4 in the micromolar range. Crystal structures showed that compound 4 binds to the PRMT4 active site, displacing strongly the S-adenosyl-L-methionine cofactor, occupying its binding site, and interacting with the arginine substrate site through the cytosine moiety that probes the space filled by a substrate peptide methylation intermediate. Furthermore, the binding of the compounds induces important structural switches. These findings open new routes for the conception of new potent PRMT4 inhibitors based on the 5-methylcytosine-adenosine scaffold.This article is part of a discussion meeting issue ‘Frontiers in epigenetic chemical biology’.

Supplementary material from "Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMTs inhibitors";Ludovic Halby;2018;The Royal Society


CCDC 2357634: Experimental Crystal Structure Determination;Erden, Kübra;2024;Cambridge Crystallographic Data Centre

Related Article: Kübra Erden, Dilek Soyler, Alberto Barsella, Onur Şahin, Saniye Soylemez, Cagatay Dengiz|2024|J.Org.Chem.|89|13192|doi:10.1021/acs.joc.4c01328


Related Article: Elodie Chevallot-Beroux, Ayuk M. Ako, Wolfgang Schmitt, Brendan Twamley, Joseph Moran, Boudon Corinne, Laurent Ruhlmann, Samir Mameri|2019|Dalton Trans.|48|4830|doi:10.1039/C8DT04807J

CCDC 1882362: Experimental Crystal Structure Determination;Chevallot-Beroux, Elodie;2019;Cambridge Crystallographic Data Centre


Related Article: Hagen Kaemmerer, Valeriu Mereacre, Ayuk M. Ako, Samir Mameri, Christopher E. Anson, Rodolphe Clérac, Annie K. Powell|2021|Chem.-Eur.J.|27|15096|doi:10.1002/chem.202102912

CCDC 2101900: Experimental Crystal Structure Determination;Kaemmerer, Hagen;2021;Cambridge Crystallographic Data Centre


Related Article: Maksym Dekhtiarenko, Simon Pascal, Mourad Elhabiri, Valerie Mazan, David Canevet, Magali Allain, Vincent Carré, Frédéric Aubriet, Zoia Voitenko, Marc Sallé, Olivier Siri, Sébastien Goeb|2021|Chem.-Eur.J.|27|15922|doi:10.1002/chem.202103039

CCDC 2096158: Experimental Crystal Structure Determination;Dekhtiarenko, Maksym;2021;Cambridge Crystallographic Data Centre


Related Article: Young Hoon Lee, Youssef Atoini, Sotaro Kusumoto, Shinya Hayami, Yang Kim, Jack Harrowfield, Pierre Thuéry|2024|Polyhedron|262|117172|doi:10.1016/j.poly.2024.117172

CCDC 2360060: Experimental Crystal Structure Determination;Lee, Young Hoon;2024;Cambridge Crystallographic Data Centre


CCDC 2360061: Experimental Crystal Structure Determination;Lee, Young Hoon;2024;Cambridge Crystallographic Data Centre


Related Article: A.Yu. Ledneva, N.G. Naumov, N. Kyritsakas, S. Ferlay|2024|Inorg.Chim.Acta|571|122212|doi:10.1016/j.ica.2024.122212

CCDC 2326356: Experimental Crystal Structure Determination;Ledneva, A.Yu.;2024;Cambridge Crystallographic Data Centre


CCDC 2326357: Experimental Crystal Structure Determination;Ledneva, A.Yu.;2024;Cambridge Crystallographic Data Centre


CCDC 2326355: Experimental Crystal Structure Determination;Ledneva, A.Yu.;2024;Cambridge Crystallographic Data Centre


Abstract: excel file with data from dyadic encounter tests

glmm_dyatics_file_time from Tolerant mothers: aggression does not explain solitary living in the bush Karoo rat;Lindelani Makuya;2024;The Royal Society


Abstract: R script for the analyses

masterfile_amicable from Tolerant mothers: aggression does not explain solitary living in the bush Karoo rat;Lindelani Makuya;2024;The Royal Society


Abstract: excel file with data from intruder tests

intruder_test_forR from Tolerant mothers: aggression does not explain solitary living in the bush Karoo rat;Lindelani Makuya;2024;The Royal Society


glmm_dyadics_file_time_mothers from Tolerant mothers: aggression does not explain solitary living in the bush Karoo rat;Lindelani Makuya;2024;The Royal Society


CCDC 2170238: Experimental Crystal Structure Determination;Sheng, Jinyu;2024;Cambridge Crystallographic Data Centre

Related Article: Jinyu Sheng, Wojciech Danowski, Jiaxin Hou, Andy S. Sardjan, Stefano Crespi, Wybren Jan Buma, Wesley R. Browne, Ben L. Feringa|2024|CSD Communication||| Related Article: Jinyu Sheng, Wojciech Danowski, Andy S. Sardjan, Jiaxin Hou, Stefano Crespi, Alexander Ryabchun, Maximilian Paradiz Domínguez, Wybren Jan Buma, Wesley R. Browne, Ben L. Feringa|2024|Nature Chemistry|16|1330|doi:10.1038/s41557-024-01521-0


CCDC 2170239: Experimental Crystal Structure Determination;Sheng, Jinyu;2024;Cambridge Crystallographic Data Centre


CCDC 2170240: Experimental Crystal Structure Determination;Sheng, Jinyu;2024;Cambridge Crystallographic Data Centre


CCDC 2264532: Experimental Crystal Structure Determination;Sheng, Jinyu;2024;Cambridge Crystallographic Data Centre


CCDC 2264533: Experimental Crystal Structure Determination;Sheng, Jinyu;2024;Cambridge Crystallographic Data Centre

Related Article: Jinyu Sheng, Wojciech Danowski, Jiaxin Hou, Andy S. Sardjan, Stefano Crespi, Maximilian Paradiz Dominguez, Wybren Jan Buma, Wesley R. Browne, Ben L. Feringa|2024|CSD Communication||| Related Article: Jinyu Sheng, Wojciech Danowski, Andy S. Sardjan, Jiaxin Hou, Stefano Crespi, Alexander Ryabchun, Maximilian Paradiz Domínguez, Wybren Jan Buma, Wesley R. Browne, Ben L. Feringa|2024|Nature Chemistry|16|1330|doi:10.1038/s41557-024-01521-0


CCDC 2325120: Experimental Crystal Structure Determination;Brouillac, Clément;2024;Cambridge Crystallographic Data Centre

Related Article: Clément Brouillac, Ari Serez, Nemo McIntosh, Joëlle Rault-Berthelot, Olivier Jeannin, Benoît Heinrich, Cassandre Quinton, Olivier De Sagazan, Emmanuel Jacques, Jérôme Cornil, Cyril Poriel|2024|J.Mater.Chem.C|12|12598|doi:10.1039/D4TC02304H


Abstract: Background:Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population more than 50 is more susceptible to cancer, and this risk may be increased by frequent use of immunosuppressive drugs. Consequently, concerns have arisen about the potential increased risk of cancer in PwMS and how patients should be screened and managed in terms of cancer risk.Objective:To develop evidence-based recommendations to manage the coexistence of cancer and multiple sclerosis (MS).Methods:The French Group for Recommendations in MS collected articles from PubMed and university databases covering the period January 1975 through June 2022. The RAND/UCLA method was employed to achieve formal consensus. MS experts comprehensively reviewed the full-text articles and developed the initial recommendations. A group of multidisciplinary health care specialists then validated the final proposal.Results:Five key questions were addressed, encompassing various topics such as cancer screening before or after initiating a disease-modifying therapy (DMT), appropriate management of MS in the context of cancer, recommended follow-up for cancer in patients receiving a DMT, and the potential reintroduction of a DMT after initial cancer treatment. A strong consensus was reached for all 31 recommendations.Conclusion:These recommendations propose a strategic approach to managing cancer risk in PwMS.

Cancer and multiple sclerosis: 2023 recommendations from the French Multiple Sclerosis Society;Nicolas Collongues;2024;SAGE Journals


Abstract: Background:Epidemiologic studies on coronavirus disease 2019 (COVID-19) in patients with multiple sclerosis (pwMS) have focused on the first waves of the pandemic until early 2021.Objectives:We aimed to extend these data from the onset of the pandemic to the global coverage by vaccination in summer 2022.Methods:This retrospective, multicenter observational study analyzed COVISEP registry data on reported COVID-19 cases in pwMS between January 2020 and July 2022. Severe COVID-19 was defined as hospitalization or higher severity.Results:Among 2584 pwMS with confirmed/highly suspected COVID-19, severe infection rates declined from 14.6% preomicron wave to 5.7% during omicron wave (<i>p</i> < 0.001). Multivariate analysis identified age (odds ratio (OR) = 1.43, 95% confidence interval (CI) = [1.25–1.64] per 10 years), male sex (OR = 2.01, 95% CI = [1.51–2.67]), obesity (OR = 2.36, 95% CI = [1.52–3.68]), cardiac comorbidities (OR = 2.36, 95% CI = [1.46–3.83]), higher Expanded Disability Status Scale (EDSS) scores (OR = 2.09, 95% CI = [1.43–3.06] for EDSS 3–5.5 and OR = 4.53, 95% CI = [3.04–6.75] for EDSS ⩾6), and anti-CD20 therapies (OR = 2.67, 95% CI = [1.85–3.87]) as risk factors for COVID-19 severity. Vaccinated individuals experienced less severe COVID-19, whether on (risk ratio (RR) = 0.64, 95% CI = [0.60–0.69]) or off (RR = 0.32, 95% CI = [0.30–0.33]) anti-CD20.Discussion:In pwMS, consistent risk factors were anti-CD20 therapies and neurological disability, emerging as vital drivers of COVID-19 severity regardless of wave, period, or vaccination status.

COVID-19 outcomes in patients with multiple sclerosis: Understanding changes from 2020 to 2022;Lina Jeantin;2024;SAGE Journals


Abstract: The increasing use of 3-dimensional (3D) imaging by orthodontists and maxillofacial surgeons to assess complex dentofacial deformities and plan orthognathic surgeries implies a critical need for 3D cephalometric analysis. Although promising methods were suggested to localize 3D landmarks automatically, concerns about robustness and generalizability restrain their clinical use. Consequently, highly trained operators remain needed to perform manual landmarking. In this retrospective diagnostic study, we aimed to train and evaluate a deep learning (DL) pipeline based on SpatialConfiguration-Net for automatic localization of 3D cephalometric landmarks on computed tomography (CT) scans. A retrospective sample of consecutive presurgical CT scans was randomly distributed between a training/validation set (n = 160) and a test set (n = 38). The reference data consisted of 33 landmarks, manually localized once by 1 operator(n = 178) or twice by 3 operators (n = 20, test set only). After inference on the test set, 1 CT scan showed “very low” confidence level predictions; we excluded it from the overall analysis but still assessed and discussed the corresponding results. The model performance was evaluated by comparing the predictions with the reference data; the outcome set included localization accuracy, cephalometric measurements, and comparison to manual landmarking reproducibility. On the hold-out test set, the mean localization error was 1.0 ± 1.3 mm, while success detection rates for 2.0, 2.5, and 3.0 mm were 90.4%, 93.6%, and 95.4%, respectively. Mean errors were −0.3 ± 1.3° and −0.1 ± 0.7 mm for angular and linear measurements, respectively. When compared to manual reproducibility, the measurements were within the Bland–Altman 95% limits of agreement for 91.9% and 71.8% of skeletal and dentoalveolar variables, respectively. To conclude, while our DL method still requires improvement, it provided highly accurate 3D landmark localization on a challenging test set, with a reliability for skeletal evaluation on par with what clinicians obtain.

Automatic 3-Dimensional Cephalometric Landmarking via Deep Learning;G. Dot;2022;SAGE Journals


Abstract: PurposeAcute kidney injury is a frequent complication of acute respiratory distress syndrome (ARDS). We aim to study the evolution of kidney function in patients presenting severe ARDS and requiring veno-venous extracorporeal membrane oxygenation (VV ECMO).MethodsWe conducted a multicenter retrospective study, including adult patients requiring VV ECMO for ARDS. The primary outcome was the evolution of the serum creatinine level after VV ECMO initiation. Secondary outcomes were change in urine output, and urine biochemical parameters after VV ECMO initiation.ResultsOne hundred and two patients were included. VV ECMO was initiated after a median of 6 days of mechanical ventilation, mainly for ARDS caused by COVID-19 (73%). Serum creatinine level did not significantly differ after VV ECMO initiation (P = .20). VV ECMO was associated with a significant increase in daily urine output (+6.6 mL/kg/day, [3.8;9.3] P < .001), even after adjustment for potential confounding factors; with an increase in natriuresis. The increase in urine output under VV ECMO was associated with a reduced risk of receiving kidney replacement therapy (OR 0.4 [0.2;0.8], P = .026).ConclusionsVV ECMO initiation in severe ARDS is associated with an increase in daily urine output and natriuresis, without change in glomerular filtration rate.

Kidney Increase Natriuresis but Not Glomerular Filtration Under Veno-venous ECMO, a Retrospective Study;Victor Penaud;2023;SAGE Journals


Abstract: The purpose of this article is to examine how e-retailer brands are related to the manufacturer brands they offer. This study is grounded in the experiential branding perspective focusing on multiple dimensions (i.e., sensorial, affective, and intellectual). We also examine the moderating role of the consumer’s chronological age on the effects of both manufacturer brand experience and e-retailer brand experience on brand satisfaction. A sample of 252 beauty box French subscribers took part in our study, and we used partial least squares structural equation modelling to test our hypotheses. Our findings show that manufacturer brand experience positively and directly affects e-retailer brand experience, which in turn positively affects e-retailer brand satisfaction. We also show that chronological age has a positive moderating role on the relationship between e-retailer brand experience and e-retailer brand satisfaction.

How are e-retailer brands related to the manufacturer brands they offer?;Richard Huaman-Ramirez;2022;SAGE Journals


Can misfortune lead to dishonesty?

Abstract: This article focuses on why people may become dishonest when they are unfortunate. Studies have shown that dishonesty increases in unfortunate or unfair situations, suggesting that misfortune could be used as a self-serving justification. I investigate this effect by analyzing the effect of luck on participant dishonesty in a laboratory experiment. I also control for participants’ belief about others’ honesty in fortunate and unfortunate situations. Participants were more dishonest when they were unfortunate and expected other participants to be more dishonest in similarly unfortunate situations. The similarity of the effects of fortune on expected and actual behaviors suggests that this norm can facilitate self-serving justification. The frequency of dishonest behavior was associated with higher individuals’ beliefs in others’ dishonesty. This effect was particularly important for participants who believed that others would have been dishonest even in fortunate situations. It therefore appears that the justification depends both on being unfortunate and the fact that some people assume others do not behave honestly even when they are fortunate.

Can misfortune lead to dishonesty?;Claire Mouminoux;2023;SAGE Journals


Abstract: <i>Dendrobium fimbriatum</i> Hook is an important medicinal and ornamental orchid that may lead to important drugs and cosmetics. In this study, 2 analytical strategies were combined to describe the detailed composition of a hydroethanolic extract of the whole plant. The CARAMEL approach, based on centrifugal partition chromatography and nuclear magnetic resonance data interpretation, allowed the rapid dereplication of 21 major constituents, mainly including polyols, nucleosides, zwitterionic compounds, phenolic compounds, and organic acids. Further semipreparative high-performance liquid chromatography and spectroscopic analyses led to the isolation of 6 additional compounds; 4 phenanthrenes (plicatol B, hircinol, plicatol A, and plicatol C), 1 bibenzyl (3′,4-dihydroxy-3,5′-dimethoxybibenzyl), and 1 furostanol saponin (protodioscin), as well as a new phenanthrene derivative, plicatol D. A total of 28 metabolites were structurally elucidated, among which 23 are described for this species for the first time.

Extensive Phytochemical Assessment of <i>Dendrobium fimbriatum</i> Hook (Orchidaceae);Quentin Favre-Godal;2022;SAGE Journals


Abstract: Health monitoring of laboratory rodents not only improves animal health but also enhances the validity of animal experiments. In particular, infections of laboratory animals with murine parvoviruses influence biomedical research data. Despite strict barrier housing, prevalence remains high in animal facilities, leading to increased risk of parvovirus introduction after the import of contaminated mice. Unfortunately, hygienic rederivation can be challenging, since gametes often contain residual virus material. Consequently, the process has to be closely monitored with highly sensitive diagnostic methods to verify parvovirus decontamination of the rederived progeny. However, diagnostic sensitivity of traditional methods is often low and requires testing of large animal cohorts. Therefore, we aimed to develop a powerful quantitative real-time polymerase chain reaction (qPCR) assay for the fast and reliable detection of murine parvoviruses in different sample materials. We validated the assay within an infection experiment and systematically analysed various animal-derived and environmental sample materials. We further developed a strategic risk assessment procedure for parvovirus monitoring after embryo transfer. Our novel qPCR assay reliably detected parvovirus DNA in a broad variety of sample materials, with environmental samples dominating in the acute phase of infection, whereas animal-derived samples were more suitable to detect low virus loads in the chronic phase. Here, the assay served as a highly sensitive screening method for parvovirus contamination in mouse colonies, requiring significantly lower sample sizes than traditional methods like conventional PCR and serology. Thus, the use of our novel qPCR assay substantially improves parvovirus diagnostics, enhancing research validity according to the 6Rs.

Why serology just is not enough: Strategic parvovirus risk assessment using a novel qPCR assay;Ann-Kathrin Iwantschenko;2022;SAGE Journals


Abstract: The antimalarial hydroxychloroquine (HCQ) has demonstrated several crucial properties for the treatment of systemic lupus erythematosus (SLE). Herein, we reviewed the main HCQ pharmacologic features, detailed its mechanism of action, and summarized the existing guidelines and recommendations for HCQ use in rheumatology with a systematic literature search for the randomized controlled trials focused on lupus. HCQ has been shown to decrease SLE activity, especially in mild and moderate disease, to prevent disease flare and to lower the long-term glucocorticoid need. The numerous benefits of HCQ are extended to pregnancy and breastfeeding period. Based on cohort studies, antithrombotic and metabolic HCQ’s effects were shown, including lipid-lowering properties, which might contribute to an improved cardiovascular risk. Moreover, early HCQ use in antinuclear antibodies positive individuals might delay the progression to SLE. Finally, HCQ has a significant favorable impact on long-term outcomes such as damage accrual and mortality in SLE. Based on these multiple benefits, HCQ is now the mainstay long-term treatment in SLE, recommended by current guidelines in all patients unless contraindications or side effects. The daily dose associated with the best compromise between efficacy and safety is matter of debate. The concern regarding retinal toxicity rather than proper efficacy data is the one that dictated the daily dosage of ⩽5 mg/kg/day actual body weight currently agreed upon.

Hydroxychloroquine in systemic lupus erythematosus: overview of current knowledge;Alina Dima;2022;SAGE Journals


Abstract: We investigated lexical and sub-lexical orthographic coding in bilingual visual word recognition by examining interactions between orthographic neighbourhood and markedness. In three experiments, French/English bilinguals performed a masked lexical decision task in French (L1) in which orthographically related prime words could be either marked or unmarked English (L2) words, compared to unrelated primes (e.g., wrap, trap, gift—DRAP, meaning sheet). The results yielded an overall inhibition priming effect, which was unexpectedly more robust in the marked condition than in the unmarked one. This result highlights the need to integrate both lexical competition and orthographic markedness in bilingual models such as BIA/+ and determine how the latter may modulate lexical processing in bilinguals.

Do both WRAP and TRAP inhibit the recognition of the French word DRAP? Impact of orthographic markedness on cross-language orthographic priming;Eva Commissaire;2021;SAGE Journals


Abstract: The Faculty of Dental Surgery of the University of Strasbourg would not be the great institute it is today if it were not for an admirable, or rather extraordinary, man: Robert Frank (May 21, 1924–August 7, 2020). He was the first dean of the Faculty of Dental Surgery at the University of Strasbourg, France. He was a dynamic and notorious leader. He brought forward amazing progress—in administration, dental research, and public health at both national and international levels. He was recognized for his top-quality innovative research and elected the 60th president of the International Association for Dental Research (1983–1984). Upon retirement, he continued his commitment to advancing humanity through painting his vision of the microscopic world and developing a “nanoart” vision.

Robert Frank: A Pioneer and Visionary Scientist in Oral Medicine;C. Taddei-Gross;2021;SAGE Journals


Abstract: Background:Antimalarial agents (AMs), mainly hydroxychloroquine (HCQ) and chloroquine, are the cornerstone of treatment of cutaneous and systemic lupus erythematosus. However, many aspects of AM prescription remain empirical. The aim of this study was to assess the modalities of AM prescription among physicians treating patients with lupus and to verify the assumption that AM use is heterogeneous and frequently at variance with international guidelines.Methods:We performed an international cross-sectional study among physicians involved in lupus care, using a web-based survey (from September 2019 to July 2020) addressing the main controversial aspects of AM prescription.Results:A total of 298 physicians [median age: 42 (interquartile range: 17) years, mainly internists and rheumatologists] from 35 countries participated to the study. A total of 93% used HCQ as the first-line AM, 69.5% used fixed doses of AMs (mainly 400 mg/day for HCQ) and only 37.9% adjusted the dose in case of renal failure. The main reasons for measuring HCQ blood levels were suspected non-adherence (55.7%) and failure of AM treatment (34.1%). In case of AM failure, 58.0% added an immunosuppressive agent. In case of remission, 49.7% maintained the same dose of AM, whereas 48.3% reduced the dose. One-third of respondents reported not following the American screening guidelines on AM retinal toxicity and 40.9% started retinal screening from the first year of treatment.Conclusion:This study highlights the strong heterogeneity of AM prescription in lupus, as well as several key unmet needs regarding AMs. This may be improved by developing more comprehensive recommendations and favoring dissemination among physicians.

Prescription strategy of antimalarials in cutaneous and systemic lupus erythematosus: an international survey;Arthur Petitdemange;2021;SAGE Journals


Abstract: Background:Diroximel fumarate (DRF) is a novel oral fumarate approved for relapsing forms of multiple sclerosis (MS). DRF demonstrated significantly improved gastrointestinal (GI) tolerability versus dimethyl fumarate (DMF) with fewer days of Individual Gastrointestinal Symptom and Impact Scale (IGISIS) scores ⩾2, GI adverse events (AEs), and treatment discontinuations due to GI AEs. Our aim was to evaluate the impact of GI tolerability events on quality of life (QoL) for patients with relapsing–remitting MS who received DRF or DMF in EVOLVE-MS-2.Methods:A post hoc analysis was conducted in patients who were enrolled in the randomized, blinded, 5-week, EVOLVE-MS-2 [ClinicalTrials.gov identifier: NCT03093324] study of DRF versus DMF. Patients completed daily IGISIS and Global GISIS (GGISIS) eDiary questionnaires to assess GI symptom intensity and interference with daily activities and work.Results:In total, 504 patients (DRF, n = 253; DMF, n = 251) received study drug and 502 (DRF, n = 253; DMF, n = 249) completed at least one post-baseline questionnaire. With DRF, GI symptoms were less likely to interfere ‘quite a bit’ or ‘extremely’ with regular daily activities [IGISIS: DRF, 9.5% (24/253) versus DMF, 28.9% (72/249)] or work productivity [GGISIS: DRF, 6.1% (10/165) versus DMF, 11.3% (18/159)]. DRF-treated patients had fewer days with ⩾1 h of missed work (DRF, 43 days, n = 20 versus DMF, 88 days, n = 26). DMF-treated patients reported highest GI symptom severity and missed work at week 2–3 shortly after completing the titration period, which coincided with the majority of GI-related treatment discontinuations [58.3% (7/12)]. GI tolerability AEs [DRF, 34.8% (88/253); DMF, 48.2% (121/251)], concomitant symptomatic medication use [DRF, 19.3% (17/88) versus DMF, 30.6% (37/121)], and GI-related discontinuations (DRF, 0.8% versus DMF, 4.8%) were lower with DRF versus DMF.Conclusions:The improved GI tolerability with DRF translated into clinically meaningful benefits to QoL, as patients experienced less impact on daily life and work and required less concomitant symptomatic medication use.Trial registration:[ClinicalTrials.gov identifier: NCT03093324]

Improved gastrointestinal profile with diroximel fumarate is associated with a positive impact on quality of life compared with dimethyl fumarate: results from the randomized, double-blind, phase III EVOLVE-MS-2 study;Annette Wundes;2021;SAGE Journals


Abstract: Background:Sex steroids could explain the course of multiple sclerosis (MS) in pregnancy.Objective:To compare the annualized relapse rate (ARR) 12 weeks post-partum in women treated with nomegestrol acetate (NOMAc) and 17-beta-estradiol (E2) versus placebo.Methods:POPARTMUS is a randomized, proof-of-concept trial in women with MS, receiving oral NOMAc 10 mg/day and transdermal estradiol 75 µg/week, or placebo.Results:Recruitment was stopped prematurely due to slow inclusions (n = 202). No treatment effect was observed on ARR after 12 weeks (sex steroids = 0.90 (0.58–1.39), placebo = 0.97 (0.63–1.50) (p = 0.79)).Conclusion:POPARTMUS failed showing efficacy of a NOMAc–E2 combination in preventing post-partum relapses.

Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study;Sandra Vukusic;2020;SAGE Journals


Abstract: sj-xlsx-3-qjp-10.1177_1747021820970724 for Do primates flexibly use spatio-temporal cues when foraging? by Cinzia Trapanese, Hélène Meunier and Shelly Masi in Quarterly Journal of Experimental Psychology

sj-xlsx-3-qjp-10.1177_1747021820970724 – for Do primates flexibly use spatio-temporal cues when foraging?;Cinzia Trapanese;2020;SAGE Journals


Abstract: Background:Pathogenic inflammatory pathways are largely shared between different autoimmune and inflammatory diseases (AIDs). This offers the potential to develop a given targeted therapy in several AIDs.Methods:We analyzed two clinical trials registries (ClinicalTrials.gov and EU Clinical Trials Register) to identify the targeted therapies whose development is shared between at least two of the most common AIDs [rheumatoid arthritis (RA), spondyloarthritis (SpA), cutaneous psoriasis (cPso), inflammatory bowel diseases (IBD), systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (pSS), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), giant cell arteritis (GCA), and multiple sclerosis (MS)] using an in-depth repurposing analysis.Results:We identified 142 shared targeted therapies. The four diseases in which shared targeted therapies were the most numerous were RA (n = 92), cPso (n = 67), IBD (n = 58), and SLE (n = 56). The two clusters of diseases between which the overlap of targeted therapies was the most important were RA and SLE as well as RA, SpA, cPso, and IBD. The targeted therapies which were shared by five diseases or more were abatacept, ustekinumab, rituximab, anakinra, etanercept, infliximab, secukinumab, tofacitinib, alemtuzumab, tocilizumab, adalimumab, apremilast, baricitinib, belimumab, brodalumab, filgotinib, and upadacitinib. The most frequently targeted molecules and pathways were (by descending frequency): JAK-STAT pathways, Th17 axis, TNF-α, IL-6, costimulation molecules, BAFF, CD20, BTK, chemokines and integrins, IL-1, and type I interferon.Conclusion:Many targeted therapies are developed in several AIDs, reflecting the overlap of pathogenic pathways and potential of drug repurposing. This suggests that a revision of the current, clinically based classification of AIDs towards a more mechanistic-based taxonomy might be relevant.

Shared development of targeted therapies among autoimmune and inflammatory diseases: a systematic repurposing analysis;Arthur Petitdemange;2020;SAGE Journals


Abstract: Foraging in seasonal environments can be cognitively demanding. Comparative studies have associated large brain size with a frugivorous diet. We investigated the ability of three semi-free-ranging primate species with different degrees of frugivory (Ntrials: Macaca tonkeana = 419, Macaca fascicularis = 197, Sapajus apella = 346) in developing a mental representation of the spatio-temporal distribution of food using foraging experiments. Forty-two boxes were fixed on trees, and each week (“season”), some of them were filled with fruits which were either highly preferred, or less preferred. Spatial (geometrical panels) and temporal (peel skin of the available fruit) cues were present at each season to indicate where (food location), what (which food) was available, and when. To test the flexible use of the cues in primate foraging behaviour, we first removed the spatial and temporal cues one at a time, and then, we manipulated the “seasonal” order of the available fruit. We compared the foraging performances in the absence and the presence of the cues and during the usual and unusual seasonal order. The average proportion of baited boxes chosen by the subjects in presence of both cues was high (between 73% and 98%) for all species. The primates seemed to remember the spatio-temporal food availability (or used other cues) because no difference was found between trials with or without our spatial and temporal cues. When the usual seasonal pattern was changed, they flexibly adjusted the feeding choice by using the provided temporal cues. We discuss these results also in view of a possible experimental bias.

Do primates flexibly use spatio-temporal cues when foraging?;Cinzia Trapanese;2020;SAGE Journals


Abstract: sj-xlsx-1-qjp-10.1177_1747021820970724 for Do primates flexibly use spatio-temporal cues when foraging? by Cinzia Trapanese, Hélène Meunier and Shelly Masi in Quarterly Journal of Experimental Psychology

sj-xlsx-1-qjp-10.1177_1747021820970724 – for Do primates flexibly use spatio-temporal cues when foraging?;Cinzia Trapanese;2020;SAGE Journals


Abstract: Design is a process through which customer needs are transformed into product or service specifications, and then used to develop a model or prototype. The prototype is tested, and modifications are brought to it before the production process starts. Moreover, the design process may be divided into different stages, starting from the definition of the customer needs, going through the conceptual design phase and ending up with the detailed design. In this article, we address the conceptual design phase, where the customer needs are assumed to be known. The proposed approach considers, based on customer needs, primary and secondary design criteria. Each design criterion has a set of predetermined possible values (options) from which the designer may select. Making the best selection of all the design features while satisfying the customer needs in terms of cost, quality (customer preference) and environmental performance is a combinatorial problem and therefore a decision-making framework would be helpful for the designers. In this article, the design criteria are evaluated using fuzzy technique for order preference by similarities to ideal solution based on cost, quality and environmental sustainability. A multiobjective and a single-objective binary programming models are then developed and solved, and their optimal solutions are obtained. The multiobjective solutions provide the decision makers with the possible trade-offs, whereas the single-objective model solution can be used as a final decision-making tool. The proposed approach is implemented in a user-friendly software developed by the authors. A case study is conducted using a baby car seat for which three main and six secondary design criteria are considered. The obtained results show the effectiveness of the approach used.

A decision-making framework for environmentally sustainable product design;Ali Cheaitou;2019;SAGE Journals


Abstract: Genetic quality assurance (QA), including genetic monitoring (GeMo) of inbred strains and background characterization (BC) of genetically altered (GA) animal models, should be an essential component of any QA programme in laboratory animal facilities. Genetic quality control is as important for ensuring the validity of the animal model as health and microbiology monitoring are. It should be required that studies using laboratory rodents, mainly mice and rats, utilize genetically defined animals. This paper, presented by the FELASA Working Group on Genetic Quality Assurance and Genetic Monitoring of Laboratory Murines, describes the objectives of and available methods for genetic QA programmes in rodent facilities. The main goals of any genetic QA programme are: (a) to verify the authenticity and uniformity of inbred stains and substrains, thus ensuring a genetically reliable colony maintenance; (b) to detect possible genetic contamination; and (c) to precisely describe the genetic composition of GA lines. While this publication focuses mainly on mouse and rat genetic QA, the principles will apply to other rodent species some of which are briefly mentioned within the context of inbred and outbred stocks.

Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report;Fernando Benavides;2019;SAGE Journals


Abstract: Objective:Systemic sclerosis mainly affects the microvascular network. However, macrovascular manifestations have been reported. We aimed to investigate the characteristics of systemic sclerosis patients with an amputation of a lower limb segment.Methods:We designed a retrospective, case–control, multicentric study on systemic sclerosis patients with amputation of a lower limb segment secondary to critical ischemia via the French Research Group on Systemic Sclerosis. For each case, a control (systemic sclerosis patient without lower limb symptom) was matched with sex, age (±5 years), and cutaneous subset of systemic sclerosis.Results:In total, 26 systemic sclerosis patients (mean age of 67.2 ± 10.9 years, 20 females, 21 limited cutaneous forms) with a lower limb amputation and 26 matched controls (mean age of 67.3 ± 11.2 years, 20 females, 22 limited cutaneous forms) were included. At the time of amputation, the mean disease duration was 12.8 (±8.6) years. In comparison to controls, systemic sclerosis patients with amputation had more digital ulcers (p = 0.048), history of digital ulcers (p = 0.026), and a higher prevalence of pulmonary arterial hypertension (p = 0.024). Systemic sclerosis patients with amputation were more often smokers (p = 0.008) and under corticosteroids (p = 0.015). In the multivariate model, pulmonary arterial hypertension, smoking status, and corticosteroids were independent markers associated with lower limb amputation in systemic sclerosis. In the follow-up, 10 patients (38.5%) had recurrent ischemia requiring a new limb amputation, and five patients (19.2%) had an amputation of the contralateral limb.Conclusion:This study identifies some markers associated with lower limb amputation in systemic sclerosis such as digital ulcers and pulmonary arterial hypertension and points out the high risk associated with tobacco consumption and corticosteroid use.

Characteristics of patients with systemic sclerosis suffering from a lower limb amputation: Results of a French collaborative study;Julien Bertolino;2020;SAGE Journals


Abstract: Supplemental material, Table_A2_NASH_Sensitivity_Analysis_Raw_anonymised_23MAR__online_supp for Early Health Technology Assessment during Nonalcoholic Steatohepatitis Drug Development: A Two-Round, Cross-Country, Multicriteria Decision Analysis by Aris Angelis, Mark Thursz, Vlad Ratziu, Alastair O�Brien, Lawrence Serfaty, Ali Canbay, Ingolf Schiefke, Joao Bana e Costa, Pascal Lecomte and Panos Kanavos in Medical Decision Making

Table_A2_NASH_Sensitivity_Analysis_Raw_anonymised_23MAR__online_supp – Supplemental material for Early Health Technology Assessment during Nonalcoholic Steatohepatitis Drug Development: A Two-Round, Cross-Country, Multicriteria Decision Analysis;Aris Angelis;2020;SAGE Journals


Theorizing rightist anti-consumption

Abstract: Although a large number of conceptual and empirical works on anti-consumption can be found in the marketing literature, the majority of these studies describe progressive reasons against consumption and pay little attention to rightist arguments. Building on multidisciplinary literatures, this article identifies three rightist ideological groups that are likely to engage in anti-consumption: moderate conservatives, the radical right and welfare chauvinists. We theorize rightist anti-consumption in relation to three tensions (global–national, novel–traditional, individual–communitarian), discuss the implications for marketing theory and identify possible avenues for further research. Consumer research should investigate political ideology as a dimension of anti-consumption, with particular attention paid to rightist reasons against consumption.

Theorizing rightist anti-consumption;Marine Cambefort;2019;SAGE Journals


Abstract: Background. The assessment of value along the clinical development of new biopharmaceutical compounds is a challenging task. Complex and uncertain evidence has to be analyzed, considering a multitude of value preferences from different stakeholders. Objective. To investigate the use of multicriteria decision analysis (MCDA) to support decision making during drug development while considering payer and health technology assessment (HTA) value concerns, by applying the Advance Value Framework in nonalcoholic steatohepatitis (NASH) and testing for the consistency of the results. Design. A multiattribute value theory methodology was applied and 2 rounds of decision conferences (DCs) were organized in 3 countries (England, France, and Germany), with the participation of national key experts and stakeholders using the MACBETH questioning protocol and algorithm. A total of 51 health care professionals, patient advocates, and methodologists, including (ex-) committee members or assessors from national HTA bodies, participated in 6 DCs in the study countries. Target Population. NASH patients in fibrosis stages F2 to 3 were considered. Interventions. The value of a hypothetical product profile was assessed against 3 compounds under development using their phase 2 results. Outcome Measures. DC participants’ value preferences were elicited involving criteria selection, options scoring, and criteria weighting. Results. Highly consistent valuation rankings were observed in all DCs, always favoring the same compound. Highly consistent rankings of criteria clusters were observed, favoring therapeutic benefit criteria, followed by safety profile and innovation level criteria. Limitations. There was a lack of comparative treatment effects, early evidence on surrogate endpoints was used, and stakeholder representativeness was limited in some DCs. Conclusions. The use of MCDA is promising in supporting early HTA, illustrating high consistency in results across countries and between study rounds.

Early Health Technology Assessment during Nonalcoholic Steatohepatitis Drug Development: A Two-Round, Cross-Country, Multicriteria Decision Analysis;Aris Angelis;2020;SAGE Journals


Abstract: Background:Cool and dry gas insufflation during laparoscopy induces hypothermia and cytokine increase, with significant perioperative morbidity. Our aim was to assess if warmed and humidified CO2 insufflation with HumiGard™ device can achieve significant benefits over standard insufflation in terms of risk of hypothermia, cytokine response, blood gases, and intra- and postoperative parameters, in the setting of robot-assisted radical prostatectomy (RARP).Methods:This was a prospective, randomized controlled clinical trial. Sixty-four patients with prostate cancer undergoing RARP were randomized to receive warmed and humidified CO2 insufflation with HumiGard device, plus hot air warming blanket (treatment group, H + WB), or standard CO2 insufflation, plus hot air warming blanket (control group, WB). Body core temperature (BCT), plasma levels of IL-6 and TNF-α, pain scores, and intraoperative parameters were recorded. The data were analyzed according to the Bayesian paradigm.Results:Intraoperative BCT increased in both groups during surgery, with a statistically significant difference favoring group H + WB, ending at 0.2°C higher on average than group WB. No difference across groups was shown for cytokine levels. Blood gas parameters were not affected by warmed CO2 insufflation. No statistical differences were noted for pain scores and the other intra- and postoperative parameters.Conclusions:During RARP, warm and humidified CO2 insufflation with the HumiGard device was more effective than the standard CO2 insufflation in maintaining the patient’s heat homeostasis, even if the difference was minimal. No imbalances were detected on blood gas analyses. No benefit could be shown in terms of cytokine levels and pain scores.

The impact of warmed and humidified CO2 insufflation during robotic radical prostatectomy: Results of a randomized controlled trial;Marco Oderda;2019;Figshare


Abstract: Today every aspect of our life is published and shared online, including grief. The virtual cemeteries and social networks’ use could be considered as a new modern mortuary ritual. Starting from the keyword <i>stillbirth</i>, 50 videos published on YouTube since 2008 have been analyzed qualitatively. The videos, 70% published by the mother, with an average length of 5.52 minutes, a mean of 2,429,576 views and 2,563 of comments, follow a sort of script: the second part with black and white photos, background music, and religious references. Could the continuous access to the child’s technological grave encourage a complicated grief or be a support, given by the interaction with users, limiting the sense of isolation. The parent shows his or her own conceptions about death and, as a modern baptism, presents the child to the whole society. Videos keep child’s memory alive and fuel a process of personalization and tenderness in the user.

Angels in the Clouds: Stillbirth and Virtual Cemeteries on 50 YouTube Videos;Livia Sani;2019;Figshare


Abstract: Background:Anterior cruciate ligament (ACL) reconstruction is important to prevent knee osteoarthritis. Neither of the 2 most common graft techniques—the patellar tendon (PT) or hamstring tendon (HS) graft—has demonstrated superiority in terms of the long-term osteoarthritis rate.Hypothesis:Based on the International Knee Documentation Committee (IKDC) radiographic grading system, PT grafts decrease the incidence of osteoarthritis by providing better knee stability as compared with HS grafts over 12 years of follow-up.Study Design:Cohort study; Level of evidence, 3.Methods:All adults with a first ACL rupture who underwent surgery with a PT or HS graft technique between January 2002 and December 2003 were included in the 2014 French Society of Orthopedic Surgery and Traumatology Symposium database. Baseline characteristics were collected. The primary endpoint was the occurrence of moderate to severe osteoarthritis in each group. The secondary endpoints included clinical subjective evaluations by the IKDC score and Knee injury and Osteoarthritis Outcome Score. To control the differences in baseline characteristics, the data were analyzed with propensity score matching.Results:In the cohort, 541 patients from 18 centers were included: 311 PT and 230 HS ACL reconstructions. The baseline characteristics were similar after inverse probability weighting treatment (IPWT). The occurrence of osteoarthritis was similar after IPWT (19.3% for PT and 19.6% for HS, P = .94). Age at surgery >29 years and IKDC osteoarthritis stage B at the index surgery were identified as risk factors for moderate to severe osteoarthritis. Most functional outcomes were significantly higher in the HS group; however, the difference between groups remained <10 points. Of the 106 patients who needed a medial meniscectomy, the proportion of patients with moderate to severe osteoarthritis was much higher in the HS group (43.5% vs 18.3%, P = .006). However, after IPWT, the difference was not statistically significant.Conclusion:At 12 years of follow-up, neither graft technique was superior to the other in terms of the rate of osteoarthritis.

Graft Choice and the Incidence of Osteoarthritis After Anterior Cruciate Ligament Reconstruction: A Causal Analysis From a Cohort of 541 Patients;Flore-Anne Lecoq;2018;Figshare


Abstract: Objective:This study aimed to evaluate the validity of the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale (ECPDS) to discriminate for cognitive impairment in schizophrenia.Design:This multicentre cross-sectional study used a validation design with receiver operating characteristic (ROC) curve analysis.Settings:The study was undertaken in a French network of seven outward referral centres.Subjects:We recruited individuals with clinically stable schizophrenia diagnosed based on the Structured Clinical Interview for assessing Diagnostic and Statistical Manual of Mental Disorders (4th ed., rev.; DSM-IV-R) criteria.Main measures:The index test for cognitive impairment was ECPDS (independent variable), a 13-item scale completed by a relative of the participant. The reference standard was a standardized test battery that evaluated seven cognitive domains. Cognitive impairment was the dependent variable and was defined as an average z-score more than 1 SD below the normative mean in two or more cognitive domains.Results:Overall, 97 patients were included (67 with schizophrenia, 28 with schizoaffective disorder, and 2 with schizophreniform disorder). The mean age was 30.2 (SD 7.7) years, and there were 75 men (77.3%). There were 59 (60.8%) patients with cognitive impairment on the neuropsychological battery, and the mean ECPDS score was 27.3 (SD 7.3). The ROC curve analysis showed that the optimal ECPDS cut-off was 29.5. The area under the curve was 0.77, with 76.3% specificity and 71.1% sensitivity to discriminate against cognitive impairment.Conclusion:The ECPDS is a valid triage tool for detecting cognitive impairment in schizophrenia, before using an extensive neuropsychological battery, and holds promise for use in everyday clinical practice.

Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale;Paul Roux;2018;SAGE Journals


Abstract: Both theoretical and empirical studies have shown the ability of scaling laws to reveal processes of emergence in urban systems. Nevertheless, a controversy about the robustness of results obtained with these models on empirical cases remains, regarding for instance the definition of the ‘city’ considered or the way the estimations are performed. Another source of bias is highlighted in this contribution, with respect to the non-ubiquitous character of some urban attributes (i.e. their partial absence from several cities of the system). The problem with the zero count for cities where these attributes are absent is that the technical necessities of usual estimation procedures make the analysis ignore them altogether even when they represent some valid information. This could seriously impact the results. A precise exploration of the effects of this arbitrary filtering is conducted here, and several solutions are proposed to overcome this limitation. In a case study about foreign investment towards French cities, we show that some erroneous conclusions about a hierarchical diffusion could be drawn when adopting the classical ordinary least squares approach. The framework we suggest specifies how it is possible to avoid misinterpretations deriving from the exclusion of zero values by using methods of analysis which deal with zero values specifically. The conclusion of a diffusion of foreign investment in the French urban system is then rejected.

Are the absent always wrong? Dealing with zero values in urban scaling;Olivier Finance;2018;Figshare


Abstract:
Objective:This study aimed to evaluate the validity of the Evaluation of Cognitive Processes
            involved in Disability in Schizophrenia scale (ECPDS) to discriminate for cognitive
            impairment in schizophrenia.Design:This multicentre cross-sectional study used a validation design with receiver operating
            characteristic (ROC) curve analysis.Settings:The study was undertaken in a French network of seven outward referral centres.Subjects:We recruited individuals with clinically stable schizophrenia diagnosed based on the
            Structured Clinical Interview for assessing Diagnostic and Statistical Manual of
              Mental Disorders (4th ed., rev.; DSM-IV-R) criteria.Main measures:The index test for cognitive impairment was ECPDS (independent variable), a 13-item
            scale completed by a relative of the participant. The reference standard was a
            standardized test battery that evaluated seven cognitive domains. Cognitive impairment
            was the dependent variable and was defined as an average z-score more
            than 1 SD below the normative mean in two or more cognitive domains.Results:Overall, 97 patients were included (67 with schizophrenia, 28 with schizoaffective
            disorder, and 2 with schizophreniform disorder). The mean age was 30.2 (SD 7.7) years,
            and there were 75 men (77.3%). There were 59 (60.8%) patients with cognitive impairment
            on the neuropsychological battery, and the mean ECPDS score was 27.3 (SD 7.3). The ROC
            curve analysis showed that the optimal ECPDS cut-off was 29.5. The area under the curve
            was 0.77, with 76.3% specificity and 71.1% sensitivity to discriminate against cognitive
            impairment.Conclusion:The ECPDS is a valid triage tool for detecting cognitive impairment in schizophrenia,
            before using an extensive neuropsychological battery, and holds promise for use in
            everyday clinical practice.

Screening for cognitive deficits with the Evaluation of Cognitive Processes
          involved in Disability in Schizophrenia scale;Paul Roux;2018;Figshare


Abstract: Supplemental material, sj-xlsx-2-hol-10.1177_09596836241254484 for High altitude horse use and early horse transport in eastern Eurasia: New evidence from melting ice by William Timothy Treal Taylor, Isaac A Hart, Tumurbaatar Tuvshinjargal, Jamsranjav Bayarsaikhan, Nicholas L Jarman, Peter Bittner, Paula López Calle, Logan A Blakeslee, Muhammad Zahir, Lorelei Chauvey, Gaëtan Tressières, Laure Tonasso-Calvière, Stéphanie Schiavinato, Corinne Cruaud, Jean-Marc Aury, Pedro H Oliveira, Patrick Wincker and Ludovic Orlando in The Holocene

sj-xlsx-2-hol-10.1177_09596836241254484 – Supplemental material for High altitude horse use and early horse transport in eastern Eurasia: New evidence from melting ice;William Timothy Treal Taylor;2024;SAGE Journals


Abstract: Objective:The aim of this study is to determine the effectiveness of an extended cognitive rehabilitation program in group’s sessions in multiple sclerosis.Design:Double-blind multicenter randomized trial.Participants:People with multiple sclerosis of 18 to 60 years, Expanded Disability Status Scale ⩽6.0, mild to moderate cognitive impairment.Interventions:They were randomized into cognitive rehabilitation program (ProCog-SEP) or in a placebo program. ProCog-SEP comprises 13 group’s sessions over 6 months and includes psychoeducational advices and cognitive exercises. Placebo program included non-cognitive exercises. No strategy and no cognitive advice were provided.Main measures:The primary endpoint was the percentage of verbal memory learning measured by the Selective Reminding Test. A comprehensive neuropsychological assessment is carried out before and after interventions by a neuropsychologist blinded to intervention. Effectiveness of the ProCog-SEP versus Placebo has been verified using linear regression models.Results:In total, 128 participants were randomized and 110 were included in the study after planning session in groups; 101 completed this trial (77.2% females); mean age: 46.1 years (±9.6); disease duration: 11.8 years (±7.5). ProCog-SEP was more effective in increasing in learning index (9.21 (95% confidence interval (CI): 1.43, 16.99); p = 0.02) and in working memory on manipulation (0.63 (95% CI: 0.17, 1.09); p = 0.01), and updating capacities (–1.1 (95% CI: –2.13, –0.06); p = 0.04). No difference was observed for other neuropsychological outcomes. Regarding quality of life outcomes, no change was observed between the two groups.Conclusion:These findings suggest that ProCog-SEP could improve verbal learning abilities and working memory in people with multiple sclerosis. These improvements were observed with 13 group sessions over 6 months.

Memory improvement in multiple sclerosis after an extensive cognitive rehabilitation program in groups with a multicenter double-blind randomized trial;Helene Brissart;2020;SAGE Journals


Abstract: Our study analyzes the effects of the permanent presence of cats on the health and social network of residents with pathologies in nursing home. Fifty-three residents, thirty-six caregivers, and four cats in three Alzheimer’s Disease units (“ADU”) and one Disability unit (“DISU”) were observed for 180 hours. Social networks were created via instantaneous sampling of physical proximities and social exchanges between residents, caregivers, and the cats. Our results showed that: (1) the four units behave similarly in the presence or absence of a cat (2) cats are placed at the periphery of the network and interact with residents showing a keen interest in them, and (3) caregivers who are in strong contact with the cat show a greater number of social interactions in their unit. This study, using for the first time a social network approach, opens up a new field of understanding of human-animal relationships in a care dimension.

Public Health and Health Services not elsewhere classified

Effect of a Cat’s Permanent Presence on the Health and Social Network of Older Adults With Alzheimer’s Disease or Disabilities in a Nursing Home;Héloïse Vesque-Annear;2024;SAGE Journals


Abstract: Background:Bacterial peritonitis (BP) in patients with gastrointestinal (GI) cancer has been poorly described, and its prevalence is unknown.Objectives:This study aimed to evaluate in patients with both GI cancer and ascites the prevalence of BP, associated features, mechanisms, prognosis, and the diagnostic performance of neutrophil count in ascites.Design:A retrospective, multicenter, observational study.Methods:All patients with GI cancer and ascites who underwent at least one paracentesis sample analyzed for bacteriology over a 1-year period were included. BP was defined by a positive ascites culture combined with clinical and/or biological signs compatible with infection. Secondary BP was defined as BP related to a direct intra-abdominal infectious source.Results:Five hundred fifty-seven ascites from 208 patients included were analyzed. Twenty-eight patients had at least one episode of BP and the annual prevalence rate of BP was 14%. Among the 28 patients with BP, 19 (65%) patients had proven secondary BP and 17 (59%) patients had multi-microbial BP, mainly due to Enterobacterales. A neutrophil count greater than 110/mm3 in ascites had negative and positive predictive values of 96% and 39%, respectively, for the diagnosis of BP. The median survival of patients with BP was 10 days (interquartile range 6–40) after the diagnosis.Conclusion:BP is not rare in patients with GI cancer and is associated with a poor short-term prognosis. When a patient with GI cancer is diagnosed with BP, a secondary cause should be sought. Further studies are needed to better define the best management of these patients.

Oncology and Carcinogenesis not elsewhere classified

Pharmacology and Pharmaceutical Sciences not elsewhere classified

Diagnosis and treatment of bacterial peritonitis in patients with gastrointestinal cancer: an observational multicenter study;Alix Riescher-Tuczkiewicz;2024;SAGE Journals


Abstract: High-throughput biological technologies are routinely used to generate gene expression profiling or cytogenetics data. To achieve high performance, methods available in the literature become more specialized and often require high computational resources. Here, we propose a new versatile method based on the data-ordering rank values. We use linear algebra, the Perron–Frobenius theorem and also extend a method presented earlier for searching differentially expressed genes for the detection of recurrent copy number aberration. A result derived from the proposed method is a one-sample Student’s <i>t</i>-test based on rank values. The proposed method is to our knowledge the only that applies to gene expression profiling and to cytogenetics data sets. This new method is fast, deterministic, and requires a low computational load. Probabilities are associated with genes to allow a statistically significant subset selection in the data set. Stability scores are also introduced as quality parameters.The performance and comparative analyses were carried out using real data sets. The proposed method can be accessed through an R package available from the CRAN (Comprehensive R Archive Network) website: https://cran.r-project.org/web/packages/fcros.

Analysis of high-throughput biological data using their rank values;Doulaye Dembélé;2018;Figshare


On behalf of the ETIS Registry Investigators

Abstract:
Background: It is unknown whether the influence of age on clinical outcomes post endovascular treatment (EVT) is similar in posterior circulation stroke (PCS) compared to anterior circulation stroke (ACS).
Materials and Methods: Data were extracted from the ETIS registry, a nationwide prospective, multicenter, observational registry for stroke EVT procedures in France. We included patients treated with EVT for PCS or ACS between January 2015 – August 2023. The relationship between patient age and clinical outcome variables was studied using regression analysis. Good clinical outcome was defined as modified Rankin scale score ≤2 at 90 days.
Results: The study included 935 patients with PCS and 11427 patients with ACS. There were no significant differences between PCS and ACS in the influence of age on the likelihood of good clinical outcome. The influence of age on the likelihood of mortality was significantly different. Mortality was higher for PCS between 30-85 years, without significant differences in younger or older patients. Elderly patients (≥80 years) with PCS had similar rates of good clinical outcome and mortality compared to patients with ACS from the same age group.
Conclusions:
In this comparative analysis assessing the impact of age on EVT outcomes in posterior versus anterior circulation stroke, differences were observed in middle aged patients, whereas outcomes tended to converge in young and elderly age groups. Elderly PCS patients had similar outcomes as ACS patients from the same age group.

Supplementary Material for: Influence of Age on Outcomes of Endovascular Treatment in Posterior versus Anterior Circulation Stroke: A Comparative Analysis in a Nationwide Registry;Pop R.;2024;Karger Publishers


Abstract: Compiled porosity and strain data

Supplementary Table 2 from Post-failure deformation mode switching in volcanic rock;Jamie Ian Farquharson;2024;The Royal Society


Abstract: Deformation conditions and results

Supplementary Table 1 from Post-failure deformation mode switching in volcanic rock;Jamie Ian Farquharson;2024;The Royal Society


Pristine survey. XX.

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine survey. XX. GTC follow-up observations of extremely metal-poor stars identified from Pristine and LAMOST.' (bibcode: 2023MNRAS.519.5554A)

Pristine survey. XX.;A. Arentsen;2023;Centre de Donnees Strasbourg (CDS)


Accurate SB2 radial velocities

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Masses of the components of SB2 binaries observed with Gaia. V. Accurate SB2 orbits for 10 binaries and masses of the components of 5 binaries.' (bibcode: 2020MNRAS.496.1355H)

Accurate SB2 radial velocities;J.-L. Halbwachs;2020;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine survey. X. A large population of low-metallicity stars permeates the Galactic disc.' (bibcode: 2020MNRAS.497L...7S)

Galactic disc Pristine low-metallicity stars;F. Sestito;2023;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Census and classification of low-surface-brightness structures in nearby early-type galaxies from the MATLAS survey.' (bibcode: 2020MNRAS.498.2138B)

Nearby massive early-type galaxies from MATLAS;M. Bilek;2022;Centre de Donnees Strasbourg (CDS)


Long tidal tails in merging galaxies

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Long tidal tails in merging galaxies and their implications.' (bibcode: 2020MNRAS.499.3399R)

Long tidal tails in merging galaxies;J. Ren;2023;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The ASKAP-EMU Early Science Project: 888 MHz Radio Continuum Survey of the Large Magellanic Cloud.' (bibcode: 2021MNRAS.506.3540P)

ASKAP-EMU ESP LMC Radio Continuum Survey;C.M. Pennock;2021;Centre de Donnees Strasbourg (CDS)


Radio continuum sources behind LMC

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Radio continuum sources behind the Large Magellanic Cloud.' (bibcode: 2021MNRAS.507.2885F)

Radio continuum sources behind LMC;M.D. Filipovic;2022;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' WALLABY early science - V. ASKAP H I imaging of the Lyon Group of Galaxies 351.' (bibcode: 2019MNRAS.489.5723F)

ASKAP HI imaging of the Lyon Group of Galaxies 351;B.-Q. For;2023;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The ASKAP-EMU Early Science Project. Radio Continuum Survey of the Small Magellanic Cloud.' (bibcode: 2019MNRAS.490.1202J)

ASKAP EMU ESP, Radio Continuum Survey of the SMC;T.D. Joseph;2020;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine survey - VI. The first three years of medium-resolution follow-up spectroscopy of Pristine EMP star candidates.' (bibcode: 2019MNRAS.490.2241A)

Spectroscopy of Pristine EMP star candidates;D.S. Aguado;2023;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' A dwarf disrupting - Andromeda XXVII and the North West Stream.' (bibcode: 2019MNRAS.490.2905P)

Andromeda XXVII and the North West Stream;J. Preston;2023;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Newly discovered dwarf galaxies in the MATLAS low-density fields.' (bibcode: 2020MNRAS.491.1901H)

Dwarf galaxies in the MATLAS low-density fields;R. Habas;2023;Centre de Donnees Strasbourg (CDS)


Andromeda XIX member stars

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' A detailed study of Andromeda XIX, an extreme local analogue of ultradiffuse galaxies.' (bibcode: 2020MNRAS.491.3496C)

Andromeda XIX member stars;Collins M.L.M.;2021;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine Dwarf-Galaxy survey. II. In-depth observational study of the faint Milky Way satellite Sagittarius II.' (bibcode: 2020MNRAS.491..356L)

Sagittarius II study with the Pristine survey;N. Longeard;2023;Centre de Donnees Strasbourg (CDS)


Abstract: An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Inorganic Crystal Structure Database (ICSD)

Related Article: Feng-Yuan Zhu, Bao-De Wu, Ming-Hao Du, Jian-Lin Yao, Brendan F. Abrahams, Hongwei Gu, Pierre Braunstein, Jian-Ping Lang|2024|J.Org.Chem.|89|11414|doi:10.1021/acs.joc.4c01089

CSD 2110457: Experimental Crystal Structure Determination;Zhu, Feng-Yuan;2024;FIZ Karlsruhe - Leibniz Institute for Information Infrastructure


Abstract: To protect the unique and rich biodiversity of the Southern Ocean, conservation measures such as marine protected areas (MPAs) have been implemented. Currently, the establishment of several additional protection zones is being considered based on the known habitat distributions of key species of the ecosystems including emperor penguins and other marine top predators. However, the distribution of such species at sea is often insufficiently sampled. Specifically, current distribution models focus on the habitat range of adult animals and neglect that immatures and juveniles can inhabit different areas. By tracking eight juvenile emperor penguins in the Weddell Sea over one year and performing a meta-analysis including previously known data from other colonies, we show that conservation efforts in the Southern Ocean are insufficient for protecting this highly mobile species, and particularly its juveniles. We find that juveniles spend ~90% of their time outside the boundaries of proposed and existing MPAs, and that their distribution extends beyond (> 1500 km) the species’ extent of occurrence as defined by the International Union for Conservation of Nature. Our data exemplify that strategic conservation plans for the Emperor penguin and other long-lived ecologically important species should consider the dynamic habitat range of all age classes.

Data from: Juvenile emperor penguin range calls for extended conservation measures in the Southern Ocean;Aymeric Houstin;2022;Movebank Data Repository


Abstract: Commercial fisheries may impact marine ecosystems and affect populations of predators like seabirds. In the Southern Ocean, there is an extensive fishery for Antarctic krill Euphausia superba that is projected to increase further. Comparing distribution and prey selection of fishing operations versus predators is needed to predict fishery-related impacts on krill-dependent predators. In this context, it is important to consider not only predators breeding near the fishing grounds but also the ones breeding far away and that disperse during the non-breeding season where they may interact with fisheries. In this study, we first quantified the overlap between the distribution of the Antarctic krill fisheries and the distribution of a krill dependent seabird, the Antarctic petrel Thalassoica antarctica, during both the breeding and non-breeding season. We tracked birds from the world biggest Antarctic petrel colony (Svarthamaren, Dronning Maud Land), located >1000 km from the main fishing areas, during three consecutive seasons. The overall spatial overlap between krill fisheries and Antarctic petrels was limited but varied greatly among and within years, and was high in some periods during the non-breeding season. In a second step, we described the length frequency distribution of Antarctic krill consumed by Antarctic petrels, and compared this with results from fisheries, as well as from diet studies in other krill predators. Krill taken by Antarctic petrels did not differ in size from that taken by trawls or from krill taken by most Antarctic krill predators. Selectivity for specific Antarctic krill stages seems generally low in Antarctic predators. Overall, our results show that competition between Antarctic petrels and krill fisheries is currently likely negligible. However, if krill fisheries are to increase in the future, competition with the Antarctic petrel may occur, even with birds breeding thousands of kilometers away.

Data from: At-sea distribution and prey selection of Antarctic petrels and commercial krill fisheries;Sébastien Descamps;2016;Movebank Data Repository


Abstract: Flight is intrinsically an energetically costly way of moving and birds have developed morphological, physiological and behavioural adaptations to minimize these costs. Central-place foraging seabirds commute regularly between nesting and foraging areas, providing us with opportunities to investigate their behavioural response to environmental conditions that may affect flight, such as wind. Here we tested hypotheses on how wind conditions influence flight behaviour in situations devoid of the confounding effect that, for instance, active foraging behaviour can have on movement patterns. We studied the Antarctic petrel, Thalassoica antarctica, a seabird breeding far inland in Antarctica and commuting through vast ice-covered areas characterized by steady and strong winds as well as a strict absence of foraging opportunities. We combined the three-dimensional location data from 79 GPS tracks with atmospheric wind data over three consecutive breeding seasons (2011-2013) in order to assess individual flight responses to wind conditions. Antarctic petrels encountered generally unfavourable winds, particularly during return flights. Despite their capacity to adjust their speed and heading in order to maintain constant track direction (compensation) in the strongest winds, they generally drifted as wind strengthened. Strong winds induced low-altitude flight. Birds tended to otherwise fly relatively high, but at altitudes with more favourable winds than what they would have encountered if flying higher. Our results show that commuting Antarctic petrels: (1) can tolerate a certain amount of drift according to wind conditions and (2) might be more limited by their ability to assess drift, rather than compensate for it, at least during returning flights.

Data from: Flexible flight response to challenging wind conditions in a commuting Antarctic seabird: do you catch the drift?;Arnaud Tarroux;2016;Movebank Data Repository

Radarsat Antarctic Mapping Project Digital Elevation Model


Abstract: An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Related Article: Janis M. Zakis, Antonis M. Messinis, Lutz Ackermann, Tomas Smejkal, Joanna Wencel-Delord|2024|Adv.Synth.Catal.|366|2292|doi:10.1002/adsc.202301411

CCDC 2266388: Experimental Crystal Structure Determination;Zakis, Janis M.;2024;Cambridge Crystallographic Data Centre


CCDC 2266392: Experimental Crystal Structure Determination;Zakis, Janis M.;2024;Cambridge Crystallographic Data Centre


CCDC 2266391: Experimental Crystal Structure Determination;Zakis, Janis M.;2024;Cambridge Crystallographic Data Centre


CCDC 2266396: Experimental Crystal Structure Determination;Zakis, Janis M.;2024;Cambridge Crystallographic Data Centre


Kinematics of the Tucana Dwarf Galaxy

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Kinematics of the Tucana Dwarf Galaxy: an unusually dense dwarf in the Local Group.' (bibcode: 2019MNRAS.485.2010G)

Kinematics of the Tucana Dwarf Galaxy;A.L. Gregory;2022;Centre de Donnees Strasbourg (CDS)


GD-1 stellar stream

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Constraining the Milky Way halo potential with the GD-1 stellar stream.' (bibcode: 2019MNRAS.486.2995M)

GD-1 stellar stream;K. Malhan;2019;Centre de Donnees Strasbourg (CDS)


VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine survey - V. A bright star sample observed with SOPHIE.' (bibcode: 2019MNRAS.487.3797B)

A bright star sample observed with SOPHIE;P. Bonifacio;2023;Centre de Donnees Strasbourg (CDS)


Accurate SB2 radial velocities

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Masses of the components of SB2 binaries observed with Gaia. IV. Accurate SB2 orbits for 14 binaries and masses of three binaries.' (bibcode: 2018MNRAS.474..731K)

Accurate SB2 radial velocities;F. Kiefer;2017;Centre de Donnees Strasbourg (CDS)


Survey of Centaurus A's Baryonic Structures II.;M.A. Taylor;2018;Centre de Donnees Strasbourg (CDS)

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Survey of Centaurus A's Baryonic Structures (SCABS). II. The extended globular cluster system of NGC 5128 and its nearby environment.' (bibcode: 2017MNRAS.469.3444T)


ASAS-SN bright supernova catalogue 2016

ASAS-SN bright supernova catalogue 2016;Holoien T.W.-S.;2020;Centre de Donnees Strasbourg (CDS)

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The ASAS-SN bright supernova catalogue - III. 2016.' (bibcode: 2017MNRAS.471.4966H)


Stellar twins in RAVE with Gaia

Stellar twins in RAVE with Gaia;P. Jofre;2020;Centre de Donnees Strasbourg (CDS)

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Climbing the cosmic ladder with stellar twins in RAVE with Gaia.' (bibcode: 2017MNRAS.472.2517J)


Metallicities of Pristine stars

Metallicities of Pristine stars;K. Youakim;2020;Centre de Donnees Strasbourg (CDS)

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' The Pristine survey. III. Spectroscopic confirmation of an efficient search for extremely metal-poor stars.' (bibcode: 2017MNRAS.472.2963Y)


Draco II stars gi magnitude & radial velocities;N.F. Martin;2018;Centre de Donnees Strasbourg (CDS)

VizieR online Data Catalogue associated with article published in journal Monthly Notices of the Royal Astronomical Society with title ' Is Draco II one of the faintest dwarf galaxies? First study from Keck/DEIMOS spectroscopy.' (bibcode: 2016MNRAS.458L..59M)


CCDC 2345906: Experimental Crystal Structure Determination;Schutz, Dorian;2024;Cambridge Crystallographic Data Centre

Related Article: Dorian Schutz, Clément Gommenginger, Baptiste Moegle, Maxime Hourtoule, Ludovik Noël-Duchesneau, Laurence Miesch|2024|J.Org.Chem.|89|10644|doi:10.1021/acs.joc.4c00878


CCDC 2345908: Experimental Crystal Structure Determination;Schutz, Dorian;2024;Cambridge Crystallographic Data Centre


CCDC 2350131: Experimental Crystal Structure Determination;Şahin, Neslihan;2024;Cambridge Crystallographic Data Centre

Related Article: Neslihan Şahin, Sametkerim Zengin, İsmail Özdemir, David Sémeril|2024|Polyhedron|261|117144|doi:10.1016/j.poly.2024.117144


CCDC 2359001: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre

Related Article: Louis Caussin, Abdelaziz Jouaiti, Daniel Chartrand, W. G. Skene, Sylvie Ferlay|2024|Dalton Trans.|53|12755|doi:10.1039/D4DT01645A


CCDC 2350748: Experimental Crystal Structure Determination;Trapali, Adelais;2024;Cambridge Crystallographic Data Centre

Related Article: Adelais Trapali, Mukil Muppal, Satakshi Pandey, Marie-Laure Boillot, Vincent Repain, Yannick J. Dappe, Jean-François Dayen, Eric Rivière, Régis Guillot, Marie-Anne Arrio, Edwige Otero, Amandine Bellec, Talal Mallah|2024|Dalton Trans.|53|12519|doi:10.1039/D4DT01417K


CCDC 2350749: Experimental Crystal Structure Determination;Trapali, Adelais;2024;Cambridge Crystallographic Data Centre


CCDC 2358999: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre


CCDC 2359000: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre


20214047

20214047;Nicolas Jaouen;2024;Elettra Sincrotrone Trieste


CCDC 2339433: Experimental Crystal Structure Determination;Benda, Lorien;2024;Cambridge Crystallographic Data Centre

Related Article: Lorien Benda, Louise Miton, Nihal Hadj Seyd, Lise-Marie Chamoreau, Gediminas Jonusauskas, Nathan D. McClenaghan, Bernold Hasenknopf, Valérie Marvaud, Guillaume Vives|2024|Dalton Trans.|53|12477|doi:10.1039/D4DT01153H


CCDC 2339432: Experimental Crystal Structure Determination;Benda, Lorien;2024;Cambridge Crystallographic Data Centre


CCDC 2359002: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre


CCDC 2359003: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre


CCDC 2359004: Experimental Crystal Structure Determination;Caussin, Louis;2024;Cambridge Crystallographic Data Centre


Abstract: This R code was used to produce results and figures in the Ecology Letters manuscript entitled “The demographic basis of population growth: a 32-year transient life table response experiment” by F. Stephen Dobson, David N. Koons, Claire Saraux, Anouch Tamian, Madan K. Oli, and Vincent A. Viblanc.

<b>The demographic basis of population growth: a 32-year transient life table response experiment</b>;F. Stephen Dobson;2024;figshare

Natural Sciences and Engineering Research Council


CCDC 2277223: Experimental Crystal Structure Determination;Zakis, Janis M.;2024;Cambridge Crystallographic Data Centre


Abstract: Phenotypic differences often stem from genetic/maternal differences and/or early-life adaptations to local environmental conditions. In colonial animals, little is known on how variation in the social environment is embedded into individual phenotypes, nor what the consequences are on individual fitness. We conducted an experimental cross-fostering study on king penguins (Aptenodytes patagonicus), exchanging eggs among 134 pairs breeding in high-density (67 pairs) or low-density (67 pairs) areas of the same breeding colony. We investigated differences in parent and chick phenotypes and survival in relation to the density of their origin and foster environment. Adults breeding in colony areas of high density exhibited decreased resting behavior and increased aggression and vigilance, increased hypometabolism during incubation fasts, and more moderate CORT responses to chronic stressors (e.g., constant aggression by neighbors). Chick phenotypes were more influenced by the environment in which they were reared than their genetic/maternal origin. Chicks reared in high-density colonial environments showed enhanced weight gain and survival rates regardless of the density of their genetic parents’ breeding areas. Our study experimentally shows advantages to breeding in colonial areas of higher breeder densities in king penguins, and highlights the importance of social settings in shaping phenotype expression in colonial seabirds.

Supplementary material from "Social, not genetic, programming of development and stress physiology of a colonial seabird";Camille Lemonnier;2024;The Royal Society


bis{[2,6-bis(1H-pyrazol-1-yl)pyridin-4-yl]methyl acetate}-iron perchlorate acetonitrile solvate

CCDC 1953350: Experimental Crystal Structure Determination;Kuppusamy, Senthil Kumar;2024;Cambridge Crystallographic Data Centre

Related Article: Senthil Kumar Kuppusamy, Asato Mizuno, Lea Kämmerer, Soma Salamon, Benoît Heinrich, Corinne Bailly, Ivan Šalitroš, Heiko Wende, Mario Ruben|2024|Dalton Trans.|53|10851|doi:10.1039/D4DT00429A


bis[ethyl 2,6-bis(1H-pyrazol-1-yl)pyridine-4-carboxylate]-iron(ii) bis(tetrafluoroborate) acetonitrile solvate

CCDC 2330939: Experimental Crystal Structure Determination;Kuppusamy, Senthil Kumar;2024;Cambridge Crystallographic Data Centre


Abstract: We provide a database that embodies more than 7000 punctual observations of the coseismic surface geological effects following the 30 October 2016 Mw 6.5 earthquake that hit central Italy. This earthquake caused widespread surface ruptures over a >400 km2-wide mountainous area. The Open EMERGEO Working Group, originated by the collaboration of several European geological survey teams coordinated by the Istituto Nazionale di Geofisica e Vulcanologia, involved about 130 researchers to perform detailed geological field surveys in the epicentral region. These observations mostly include accurate description of the geometry and kinematics of ground breaks caused by primary surface faulting, and subordinately by landslides due to shaking.The database consists of georeferenced records containing both numeric and string fields in the form of a suitable .txt file.

Coseismic surface geological effects following the 30 October 2016 Mw 6.5 earthquake, central Italy;Fabio Villani;2017;PANGAEA

Supplement to: Villani, Fabio; Civico, Riccardo; Pizzimenti, Luca; Pucci, Stefano; De Martini, Paolo Marco; Nappi, Rosa; Open EMERGEO Working Group (2018): A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy. Scientific Data, 5, 180049